Ligand ID: HCY


Drugbank ID:
DB00741
(Hydrocortisone)


Indication:
For the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. Also used to treat endocrine (hormonal) disorders (adrenal insufficiency, Addisons disease). It is also used to treat many immune and allergic disorders, such as arthritis, lupus, severe psoriasis, severe asthma, ulcerative colitis, and Crohn's disease.

Get human targets for HCY in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'HCY'

Click here for results that match SARS-Cov-2 / COVID-19 structures only
Click here for results that match SARS-related structures only


1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_A_HCYA900_1
(GLUCOCORTICOID
RECEPTOR)		1q2w 3C-LIKE PROTEASE
(SARSr-CoV)		5 / 12
LEU B 177
GLY B 179
GLN B  83
ARG B  88
ILE B 106
1.59A19.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		1qz8 POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
ALA A  30
VAL A  41
GLN A  20
ARG A  39
ILE A  65
1.53A15.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		1uj1 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL A 296
PHE B 140
ASN A 214
SER B 139
TRP A 207
1.79A22.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_G_HCYG900_2
(GLUCOCORTICOID
RECEPTOR)		1uk3 3C-LIKE PROTEINASE
(SARSr-CoV)		3 / 3
LEU B 287
MET B 264
TYR B 237
1.45A19.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		1uw7 NSP9
(SARS-COV
HKU-39849)		5 / 12
ALA A  30
VAL A  41
GLN A  20
ARG A  39
ILE A  65
1.56A16.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		1z1j 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ALA A 206
PRO A 293
VAL A 296
ILE A 213
PHE A   3
1.69A23.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		1zv8 E2 GLYCOPROTEIN
(SARSr-CoV)		5 / 12
ALA K  38
SER J   8
VAL I  33
ILE J  12
ASN J  11
1.68A9.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HGC_A_HCYA501_1
(SERPIN)		1zv8 E2 GLYCOPROTEIN
(SARSr-CoV)		5 / 12
ALA E  12
THR A  21
ILE A  16
SER A  14
ASN F  27
1.61A8.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_E_HCYE900_1
(GLUCOCORTICOID
RECEPTOR)		2ajf ACE2
(Homo
sapiens)		5 / 12
GLY B 405
MET B 408
LEU B 410
GLN B 524
PHE B 400
1.44A17.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		2ajf ACE2
(Homo
sapiens)		5 / 12
ALA A 296
VAL A 293
GLN A 429
PHE A 428
ILE A 291
1.73A22.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		2beq SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
ALA B 938
SER D1157
VAL A 933
ILE D1161
ASN D1160
1.69A8.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_E_HCYE900_1
(GLUCOCORTICOID
RECEPTOR)		2c3s 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
LEU A 177
GLY A 179
GLN A  83
ARG A  88
ILE A 106
1.46A19.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_1
(GLUCOCORTICOID
RECEPTOR)		2c3s 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
LEU A 177
GLY A 179
GLN A  83
ARG A  88
ILE A 106
1.53A19.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_A_HCYA900_1
(GLUCOCORTICOID
RECEPTOR)		2c3s 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
LEU A 177
GLY A 179
GLN A  83
ARG A  88
ILE A 106
1.41A19.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_K_HCYK900_1
(GLUCOCORTICOID
RECEPTOR)		2c3s 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
GLY A 179
GLN A  83
MET A 162
ARG A  88
PHE A 181
1.73A19.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_G_HCYG900_1
(GLUCOCORTICOID
RECEPTOR)		2c3s 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
GLY A 179
GLN A  83
MET A 162
ARG A  88
PHE A 181
1.68A19.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_1
(GLUCOCORTICOID
RECEPTOR)		2cjr NUCLEOCAPSID PROTEIN
(SARS-COV
TW1)		5 / 12
ASN C 286
GLY C 279
GLN C 284
ARG C 260
ILE C 358
1.68A20.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_G_HCYG900_1
(GLUCOCORTICOID
RECEPTOR)		2cjr NUCLEOCAPSID PROTEIN
(SARS-COV
TW1)		5 / 12
ASN C 286
GLY C 279
GLN C 284
ARG C 260
ILE C 358
1.74A20.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_K_HCYK900_1
(GLUCOCORTICOID
RECEPTOR)		2cjr NUCLEOCAPSID PROTEIN
(SARS-COV
TW1)		5 / 12
ASN C 286
GLY C 279
GLN C 284
ARG C 260
ILE C 358
1.66A20.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		2dd8 IGG LIGHT CHAIN
(Homo
sapiens)		5 / 12
ALA L 176
VAL L 145
GLN L 109
ASP L 139
LYS L 167
1.72A20.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		2dd8 IGG HEAVY CHAIN
(Homo
sapiens)		5 / 12
THR H  71
ARG H  94
ILE H  34
ASP H  95
PHE H  29
1.68A21.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_1
(GLUCOCORTICOID
RECEPTOR)		2fe8 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
GLY B 143
GLN B  98
LEU B 102
ILE B 152
PHE B 148
1.62A21.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		2ghw ANTI-SCFV ANTIBODY,
80R
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARSr-CoV)		5 / 12
THR D 204
ARG D 162
SER D 184
PHE D 203
TRP C 476
1.57A21.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		2ghw ANTI-SCFV ANTIBODY,
80R
(Homo
sapiens)		5 / 12
VAL B 161
THR B 204
ARG B 162
SER B 184
PHE B 203
1.72A20.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		2gtb 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
GLN A 127
PHE A   8
ILE A 152
ASP A 153
PHE A 150
1.71A23.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_E_HCYE900_1
(GLUCOCORTICOID
RECEPTOR)		2h85 PUTATIVE ORF1AB
POLYPROTEIN
(SARSr-CoV)		5 / 12
LEU A  75
ASN A  74
GLY A  76
LEU A 122
THR A 274
1.46A20.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		2h85 PUTATIVE ORF1AB
POLYPROTEIN
(SARSr-CoV)		5 / 12
VAL A 318
PHE A 302
ILE A 305
PHE A 341
HIS A 249
1.76A22.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_G_HCYG900_2
(GLUCOCORTICOID
RECEPTOR)		2h85 PUTATIVE ORF1AB
POLYPROTEIN
(SARSr-CoV)		3 / 3
LEU A 299
MET A 251
TYR A 193
1.38A20.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_1
(GLUCOCORTICOID
RECEPTOR)		2h85 PUTATIVE ORF1AB
POLYPROTEIN
(SARSr-CoV)		5 / 12
LEU A  75
ASN A  74
GLY A  76
LEU A 122
THR A 274
1.52A20.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_A_HCYA900_1
(GLUCOCORTICOID
RECEPTOR)		2h85 PUTATIVE ORF1AB
POLYPROTEIN
(SARSr-CoV)		5 / 12
LEU A  75
ASN A  74
GLY A  76
LEU A 122
THR A 274
1.52A20.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		2h85 PUTATIVE ORF1AB
POLYPROTEIN
(SARSr-CoV)		5 / 12
SER A  25
VAL A  31
GLN A   0
SER A   1
PHE A  55
1.76A22.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		2jzf REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
ALA A 555
VAL A 553
GLN A 570
PHE A 582
ILE A 549
1.52A18.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HGC_A_HCYA501_1
(SERPIN)		2k87 NSP3 OF REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		5 / 12
VAL A  10
PRO A  11
ALA A  78
PHE A  55
ILE A  65
1.22A17.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		2k87 NSP3 OF REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		6 / 12
ALA A  78
PRO A  11
PHE A  55
ILE A   7
ASP A   8
LYS A  83
1.54A14.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_A_HCYA900_1
(GLUCOCORTICOID
RECEPTOR)		2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 12
LEU C  75
ASN C  74
GLY C  76
LEU C 122
THR C 274
1.43A20.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_E_HCYE900_1
(GLUCOCORTICOID
RECEPTOR)		2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 12
LEU C  75
ASN C  74
GLY C  76
LEU C 122
THR C 274
1.38A20.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_G_HCYG900_2
(GLUCOCORTICOID
RECEPTOR)		2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		3 / 3
LEU B 299
MET B 251
TYR B 193
1.39A20.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_1
(GLUCOCORTICOID
RECEPTOR)		2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 12
LEU C  75
ASN C  74
GLY C  76
LEU C 122
THR C 274
1.45A20.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_A_HCYA900_1
(GLUCOCORTICOID
RECEPTOR)		2q6g REPLICASE
POLYPROTEIN 1AB
(SARS-COV
BJ01)		5 / 12
LEU A 177
GLY A 179
GLN A  83
ARG A  88
ILE A 106
1.60A19.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_G_HCYG900_2
(GLUCOCORTICOID
RECEPTOR)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		3 / 3
LEU D 299
MET D 251
TYR D 193
1.32A20.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_1
(GLUCOCORTICOID
RECEPTOR)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 12
LEU D  75
ASN D  74
GLY D  76
LEU D 122
THR D 274
1.46A20.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_A_HCYA900_1
(GLUCOCORTICOID
RECEPTOR)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 12
LEU D  75
ASN D  74
GLY D  76
LEU D 122
THR D 274
1.44A20.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 12
VAL A 318
PHE A 302
ILE A 305
PHE A 341
HIS A 249
1.73A22.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_E_HCYE900_1
(GLUCOCORTICOID
RECEPTOR)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 12
LEU D  75
ASN D  74
GLY D  76
LEU D 122
THR D 274
1.39A20.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 12
SER F 328
VAL F 318
PHE F 302
ILE F 305
PHE F 341
1.69A22.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		2w2g NSP3
(SARSr-CoV)		5 / 12
VAL A 457
THR A 486
ILE A 459
ASP A 416
PHE A 414
1.75A19.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		2xyq PUTATIVE 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		5 / 12
ALA A  83
THR A 195
PHE A 205
ILE A 128
LYS A  46
1.76A22.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_G_HCYG900_1
(GLUCOCORTICOID
RECEPTOR)		2xyq PUTATIVE 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		5 / 12
ASN A  29
GLY A  31
MET A  42
LEU A 239
THR A 172
1.71A24.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_G_HCYG900_1
(GLUCOCORTICOID
RECEPTOR)		2xyr PUTATIVE 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		5 / 12
ASN A  29
GLY A  31
MET A  42
LEU A 239
THR A 172
1.68A23.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		2xyv PUTATIVE 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		5 / 12
ALA A  83
THR A 195
PHE A 205
ILE A 128
LYS A  46
1.75A22.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_A_HCYA900_1
(GLUCOCORTICOID
RECEPTOR)		3avz 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
LEU A 177
GLY A 179
GLN A  83
ARG A  88
ILE A 106
1.59A19.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HGC_A_HCYA501_1
(SERPIN)		3bgf F26G19 FAB
(Mus
musculus)		5 / 12
PRO L 204
ALA L 196
THR L 172
ILE L 144
PHE L 139
1.63A21.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_1
(GLUCOCORTICOID
RECEPTOR)		3d0i ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 12
LEU B 440
ASN B 437
GLN B 598
LEU B 595
ILE B 291
1.62A18.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_E_HCYE900_1
(GLUCOCORTICOID
RECEPTOR)		3d0i ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 12
GLY B 405
MET B 408
LEU B 410
GLN B 524
PHE B 400
1.39A18.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HGC_A_HCYA501_1
(SERPIN)		3d0i ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 12
ALA B 311
THR B 334
ILE B 358
SER B 331
PHE B 308
1.66A20.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		3ea7 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
GLN A 127
PHE A   8
ILE A 152
ASP A 153
PHE A 150
1.59A23.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		3eaj 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
SER B 113
VAL B 114
ILE B 136
PHE B 140
HIS B 164
1.78A23.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		3ee7 REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		5 / 12
ALA A  30
VAL A  41
GLN A  20
ARG A  39
ILE A  65
1.58A17.17
None
GOL  A 127 (-4.0A)
None
PO4  A 124 (-3.0A)
GOL  A 127 ( 4.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		3f9g 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
GLN A 127
PHE A   8
ILE A 152
ASP A 153
PHE A 150
1.70A23.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_G_HCYG900_2
(GLUCOCORTICOID
RECEPTOR)		3f9h 3C-LIKE PROTEINASE
(SARSr-CoV)		3 / 3
LEU B 115
MET B 162
TYR B 118
1.72A19.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_E_HCYE900_1
(GLUCOCORTICOID
RECEPTOR)		3f9h 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
GLY A   2
GLN A 299
MET A   6
ARG A 298
ILE A 281
1.44A19.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_1
(GLUCOCORTICOID
RECEPTOR)		3fzd 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
LEU A  27
GLN A  19
MET A 162
ILE A  43
PHE A  66
1.42A19.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		3i6k BETA-2-MICROGLOBULIN
(Homo
sapiens)		5 / 12
VAL F  27
GLN F   2
ILE F  35
ASN F  83
PHE F  30
1.77A14.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		3iwm 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
GLN C 127
PHE C   8
ILE C 152
ASP C 153
PHE C 150
1.71A23.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		3m3v 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ALA B 116
SER B 147
VAL B 114
ILE B 136
SER A   1
1.43A23.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		3mj5 REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		5 / 12
GLN B 122
THR B 103
ASN B 111
SER B 115
PHE B  96
1.76A20.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		3r24 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		5 / 12
ALA A  83
THR A 195
PHE A 205
ILE A 128
LYS A  46
1.77A22.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_E_HCYE900_1
(GLUCOCORTICOID
RECEPTOR)		3sci ACE2
(Homo
sapiens)		5 / 12
GLY B 405
MET B 408
LEU B 410
GLN B 524
PHE B 400
1.41A17.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HGC_A_HCYA501_1
(SERPIN)		3scj ACE2
(Homo
sapiens)		5 / 12
ALA A 311
THR A 334
ILE A 358
SER A 331
PHE A 308
1.60A20.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_1
(GLUCOCORTICOID
RECEPTOR)		3sck ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 12
LEU B 440
ASN B 437
GLN B 598
LEU B 595
ILE B 291
1.63A17.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		3sck ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 12
SER A 409
PHE A 588
ILE A 446
PHE A 523
HIS A 540
1.74A20.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		3sck ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 12
SER A 409
PHE A 588
ILE A 446
PHE A 523
HIS A 540
1.73A20.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_E_HCYE900_1
(GLUCOCORTICOID
RECEPTOR)		3scl ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 12
GLY A 405
MET A 408
LEU A 410
GLN A 524
PHE A 400
1.35A17.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HGC_A_HCYA501_1
(SERPIN)		3scl ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 12
ALA A 311
THR A 334
ILE A 358
SER A 331
PHE A 308
1.65A20.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		3to2 MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
THR A  31
ARG A 170
ILE A  52
ASN A 174
PHE A  33
1.52A19.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_G_HCYG900_1
(GLUCOCORTICOID
RECEPTOR)		4mm3 PAPAIN-LIKE
PROTEINASE
UBIQUITIN
(Homo
sapiens;
SARSr-CoV)		5 / 12
GLY A  47
GLN B 233
MET B 245
LEU B 235
THR B 171
1.77A20.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		4tww 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
ALA A 206
PRO A 293
VAL A 296
GLN A 306
ILE A 213
1.64A23.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HGC_A_HCYA501_1
(SERPIN)		4tww 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL B 125
PRO A   9
ALA A   7
ARG B 298
SER A 123
1.54A20.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HGC_A_HCYA501_1
(SERPIN)		5b6o 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL A 125
PRO B   9
ALA B   7
ARG A 298
SER B 123
1.60A21.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_G_HCYG900_2
(GLUCOCORTICOID
RECEPTOR)		5c5o 3C-LIKE PROTEINASE
(SARSr-CoV)		3 / 3
LEU B 287
MET B 264
TYR B 237
1.46A19.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_2
(GLUCOCORTICOID
RECEPTOR)		5c8s GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		3 / 3
MET B 315
MET B 500
TYR B 491
1.23A20.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		5c8s GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		5 / 12
ALA D 308
SER D 307
PHE D 401
SER D 407
PHE D 506
1.23A20.42
None
None
G3A  D 606 (-3.8A)
None
G3A  D 606 (-4.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HGC_A_HCYA501_1
(SERPIN)		5c8s GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		5 / 12
PHE D  89
LYS D 165
ILE D 166
PHE D 111
ASN D 116
1.58A19.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		5c8t GUANINE-N7
METHYLTRANSFERASE
NSP10
(SARSr-CoV)		5 / 12
ALA B  23
PRO B  24
VAL A  42
THR A  56
LYS A  95
1.75A19.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		5c8t GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		5 / 12
VAL D 182
GLN D 246
ARG D 180
ILE D  74
HIS D 188
1.77A21.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		5c8t GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		5 / 12
VAL D 182
GLN D 246
ARG D 180
ILE D  74
HIS D 188
1.72A20.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		5c8t GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		5 / 12
ALA B 308
SER B 307
PHE B 401
SER B 407
PHE B 506
1.13A20.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_2
(GLUCOCORTICOID
RECEPTOR)		5c8t GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		3 / 3
MET B 315
MET B 500
TYR B 491
1.26A20.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HGC_A_HCYA501_1
(SERPIN)		5c8u GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		5 / 12
PHE D  89
LYS D 165
ILE D 166
PHE D 111
ASN D 116
1.54A19.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		5 / 12
ALA B 308
SER B 307
PHE B 401
ASN B 422
PHE B 506
1.21A20.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HGC_A_HCYA501_1
(SERPIN)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		5 / 12
VAL M   7
PRO M   8
ALA M   9
ILE M  38
ASN M  40
1.53A15.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_G_HCYG900_1
(GLUCOCORTICOID
RECEPTOR)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		5 / 12
ASN D 334
GLY D 333
ARG D 289
ILE D 338
PHE D 350
1.76A20.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		5 / 12
ALA D  23
PRO D  24
VAL O  42
THR O  56
LYS O  95
1.61A20.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		5 / 12
VAL A 182
GLN A 246
ARG A 180
ILE A  74
HIS A 188
1.73A20.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		5 / 12
VAL A 182
GLN A 246
ARG A 180
ILE A  74
HIS A 188
1.78A20.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_2
(GLUCOCORTICOID
RECEPTOR)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		3 / 3
MET A 315
MET A 500
TYR A 491
1.46A20.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HGC_A_HCYA501_1
(SERPIN)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		5 / 12
PHE C  89
LYS C 165
ILE C 166
PHE C 111
ASN C 116
1.53A19.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HGC_A_HCYA501_1
(SERPIN)		5wrg SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
ARG A 315
PHE A 316
ILE A 319
PHE A 379
ASN A 381
1.53A15.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HGC_A_HCYA501_1
(SERPIN)		5x4r S PROTEIN
(MERS-CoV)		5 / 12
VAL A 286
PRO A 285
PHE A 116
ILE A 256
PHE A 112
1.20A20.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_1
(GLUCOCORTICOID
RECEPTOR)		5x4r S PROTEIN
(MERS-CoV)		5 / 12
LEU A 169
GLY A 150
LEU A 187
ILE A 256
PHE A 112
1.68A20.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		5x4s SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
GLN A 147
THR A 150
PHE A 138
ILE A 117
SER A 120
1.70A22.22
NAG  A 602 ( 4.4A)
None
None
None
NAG  A 602 (-3.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		5x4s SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
ALA A 156
GLN A 147
THR A 150
PHE A 138
ILE A 117
1.66A21.82
None
NAG  A 602 ( 4.4A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HGC_A_HCYA501_1
(SERPIN)		5x4s SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
VAL A  80
PRO A  79
ILE A  87
PHE A 103
ASN A 230
1.42A22.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		5x4s SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
GLN A 147
THR A 150
PHE A 138
ILE A 117
SER A 120
1.78A21.82
NAG  A 602 ( 4.4A)
None
None
None
NAG  A 602 (-3.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		5x58 SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 12
ALA B1007
SER B1003
VAL B 711
THR B 856
PHE B 764
1.68A15.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_1
(GLUCOCORTICOID
RECEPTOR)		5x58 SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 12
LEU B 994
GLN B 744
LEU B 745
GLN B 992
THR C 991
1.61A11.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_A_HCYA900_1
(GLUCOCORTICOID
RECEPTOR)		5x59 S PROTEIN
(MERS-CoV)		5 / 12
LEU C 935
GLN C 927
LEU B 715
THR C 798
ILE C 799
1.58A11.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		5x59 S PROTEIN
(MERS-CoV)		5 / 12
ALA B  53
THR B  68
ILE B 337
ASP B 338
PHE B 354
1.71A14.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_1
(GLUCOCORTICOID
RECEPTOR)		5x59 S PROTEIN
(MERS-CoV)		5 / 12
LEU C 821
GLY C 825
LEU C1075
GLN C 808
THR B 693
1.57A11.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_E_HCYE900_1
(GLUCOCORTICOID
RECEPTOR)		5x59 S PROTEIN
(MERS-CoV)		5 / 12
LEU C 821
GLY C 825
LEU C1075
GLN C 808
THR B 693
1.57A11.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 12
SER B 717
VAL B 718
THR A 988
PHE B 741
SER B 740
1.66A15.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_E_HCYE900_1
(GLUCOCORTICOID
RECEPTOR)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 12
ASN A 910
GLY A 781
LEU A 776
ILE A 913
PHE A 909
1.60A11.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_A_HCYA900_1
(GLUCOCORTICOID
RECEPTOR)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 12
MET A1032
LEU A1031
GLY A 890
LEU A 898
THR A 863
1.56A11.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 12
VAL A 114
PHE A 220
ARG A 126
ILE A 125
SER A 165
1.68A15.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_G_HCYG900_1
(GLUCOCORTICOID
RECEPTOR)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 12
ASN A 910
GLY A 781
LEU A 776
ILE A 913
PHE A 909
1.63A11.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 12
VAL C 102
GLN C 147
THR C 150
PHE C 138
ILE C 234
1.36A15.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HGC_A_HCYA501_1
(SERPIN)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 12
VAL A  80
PRO A  79
ILE A  87
PHE A 103
ASN A 230
1.31A14.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		5x5f S PROTEIN
(MERS-CoV)		5 / 12
GLN C 261
THR C 283
ARG B 629
ASN B 582
SER B 439
1.69A15.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		5x5f S PROTEIN
(MERS-CoV)		5 / 12
VAL C 877
GLN B 769
ILE C 861
SER C 950
HIS B 766
1.58A14.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		5x5f S PROTEIN
(MERS-CoV)		5 / 12
GLN C 261
THR C 283
ASN B 582
SER B 439
HIS C 264
1.53A14.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HGC_A_HCYA501_1
(SERPIN)		5x5f S PROTEIN
(MERS-CoV)		5 / 12
VAL A 286
PRO A 285
PHE A 116
ILE A 256
PHE A 112
1.20A14.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_E_HCYE900_1
(GLUCOCORTICOID
RECEPTOR)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
LEU B 859
GLY B 862
LEU B1016
ILE B 787
PHE B 784
1.51A11.36
LEU  B 859 ( 0.6A)
GLY  B 862 ( 0.0A)
LEU  B1016 ( 0.6A)
ILE  B 787 ( 0.7A)
PHE  B 784 ( 1.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
ALA C 422
VAL C 496
GLN C 401
ILE C 397
ASP C 393
1.60A15.81
ALA  C 422 ( 0.0A)
VAL  C 496 ( 0.6A)
GLN  C 401 ( 0.6A)
ILE  C 397 ( 0.7A)
ASP  C 393 ( 0.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
SER B 516
VAL B 313
THR B 559
ARG B 315
PHE B 527
1.68A16.15
SER  B 516 ( 0.0A)
VAL  B 313 ( 0.6A)
THR  B 559 ( 0.8A)
ARG  B 315 ( 0.6A)
PHE  B 527 ( 1.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_A_HCYA900_1
(GLUCOCORTICOID
RECEPTOR)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
LEU B 859
GLY B 862
LEU B1016
ILE B 787
PHE B 784
1.48A11.36
LEU  B 859 ( 0.6A)
GLY  B 862 ( 0.0A)
LEU  B1016 ( 0.6A)
ILE  B 787 ( 0.7A)
PHE  B 784 ( 1.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		5zvm PAN-COV INHIBITORY
PEPTIDE EK1
SPIKE GLYCOPROTEIN
(SARSr-CoV;
synthetic
construct)		5 / 12
SER B 949
VAL B 945
GLN C 936
THR b  14
ILE b  11
1.54A13.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		5zvm PAN-COV INHIBITORY
PEPTIDE EK1
SPIKE GLYCOPROTEIN
(SARSr-CoV;
synthetic
construct)		5 / 12
SER B 949
VAL B 945
GLN C 936
THR b  14
ILE b  11
1.48A13.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		5zvm PAN-COV INHIBITORY
PEPTIDE EK1
SPIKE GLYCOPROTEIN
(SARSr-CoV;
synthetic
construct)		5 / 12
SER B 949
VAL B 945
GLN C 936
THR b  14
ILE b  11
1.59A13.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_1
(GLUCOCORTICOID
RECEPTOR)		6acc SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
LEU B 194
GLY B 225
ARG C 449
ILE B 125
PHE B 161
1.63A11.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_G_HCYG900_2
(GLUCOCORTICOID
RECEPTOR)		6acd SPIKE GLYCOPROTEIN
(SARSr-CoV)		3 / 3
LEU A 986
MET A 722
TYR A 738
1.68A11.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_1
(GLUCOCORTICOID
RECEPTOR)		6acg ACE2
(Homo
sapiens)		5 / 12
LEU D 554
GLY D 377
GLN D 526
ILE D 544
PHE D 314
1.48A17.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_A_HCYA900_1
(GLUCOCORTICOID
RECEPTOR)		6acg ACE2
(Homo
sapiens)		5 / 12
LEU D 554
GLY D 377
GLN D 526
ILE D 544
PHE D 314
1.49A17.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HGC_A_HCYA501_1
(SERPIN)		6acg SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
VAL B  80
PRO B  79
ILE B  87
PHE B 103
ASN B 230
1.32A15.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6acg ACE2
(Homo
sapiens)		5 / 12
SER D 563
GLN D 524
PHE D 525
ASN D 572
PHE D 400
1.78A20.46
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6acg ACE2
(Homo
sapiens)		5 / 12
SER D 563
GLN D 524
PHE D 525
ASN D 572
PHE D 400
1.74A19.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6acj SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
SER A 500
VAL A 498
ILE A 397
PHE A 387
TRP A 340
1.54A15.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6acj SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
SER A 500
VAL A 498
ILE A 397
PHE A 387
TRP A 340
1.40A15.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_A_HCYA900_1
(GLUCOCORTICOID
RECEPTOR)		6acj SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
LEU C 859
GLY C 862
LEU C1016
ILE C 787
PHE C 784
1.27A11.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_G_HCYG900_1
(GLUCOCORTICOID
RECEPTOR)		6acj SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
GLY C 781
LEU C 898
GLN C 883
THR C 863
PHE C 784
1.72A11.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_E_HCYE900_1
(GLUCOCORTICOID
RECEPTOR)		6acj SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
LEU C 859
GLY C 862
LEU C1016
ILE C 787
PHE C 784
1.29A11.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6acj SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
SER A 500
VAL A 498
ILE A 397
PHE A 387
TRP A 340
1.43A16.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_K_HCYK900_1
(GLUCOCORTICOID
RECEPTOR)		6ack ACE2
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARSr-CoV)		5 / 12
MET D 323
GLY C 488
GLN C 492
ILE D 379
PHE D 356
1.71A17.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6ack SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
VAL A 102
GLN A 147
THR A 150
PHE A 138
ILE A 234
1.32A15.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_G_HCYG900_2
(GLUCOCORTICOID
RECEPTOR)		6ack ACE2
(Homo
sapiens)		3 / 3
LEU D 450
MET D 579
TYR D 587
1.61A17.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
ALA C1007
SER C1003
VAL C 711
THR C 856
PHE C 764
1.63A14.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HGC_A_HCYA501_1
(SERPIN)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
VAL C  80
PRO C  79
ILE C  87
PHE C 103
ASN C 230
1.48A14.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
GLN C 147
THR C 150
PHE C 138
ASN C 122
SER C 120
1.77A14.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
ALA A 156
GLN A 147
THR A 150
PHE A 138
ILE A 117
1.50A15.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_A_HCYA900_1
(GLUCOCORTICOID
RECEPTOR)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
MET C1032
LEU C1031
GLY C 890
LEU C 898
THR C 863
1.57A11.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
SER B  95
VAL B  97
PHE B  22
SER B 239
HIS B 149
1.67A14.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_G_HCYG900_2
(GLUCOCORTICOID
RECEPTOR)		6crw SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		3 / 3
LEU C 264
MET C  37
TYR C 197
1.35A11.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6crw SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
SER C 500
VAL C 498
ILE C 405
PHE C 387
TRP C 340
1.49A14.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_E_HCYE900_1
(GLUCOCORTICOID
RECEPTOR)		6crz SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
LEU B 859
GLY B 862
LEU B1016
ILE B 787
PHE B 784
1.36A11.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6crz SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
ALA C 422
VAL C 496
GLN C 401
ILE C 405
ASP C 393
1.36A15.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_1
(GLUCOCORTICOID
RECEPTOR)		6cs0 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
LEU B 859
GLY B 862
LEU B1016
ILE B 787
PHE B 784
1.36A11.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6cs0 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
SER B 500
VAL B 498
ILE B 397
PHE B 387
TRP B 340
1.50A14.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6cs0 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
SER C 500
VAL C 498
ILE C 405
PHE C 387
TRP C 340
1.53A15.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_A_HCYA900_1
(GLUCOCORTICOID
RECEPTOR)		6cs0 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
LEU B 859
GLY B 862
LEU B1016
ILE B 787
PHE B 784
1.30A11.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_K_HCYK900_1
(GLUCOCORTICOID
RECEPTOR)		6cs1 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
GLN C 280
ARG C 620
THR C 215
ILE C 272
PHE C 213
1.64A11.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HGC_A_HCYA501_1
(SERPIN)		6cs1 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
VAL B  80
PRO B  79
ALA B 233
PHE B 103
ASN B 230
1.24A15.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_G_HCYG900_1
(GLUCOCORTICOID
RECEPTOR)		6cs1 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
ASN B 910
GLY B 781
LEU B 776
ILE B 913
PHE B 909
1.43A11.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_K_HCYK900_1
(GLUCOCORTICOID
RECEPTOR)		6cs2 ACE2
SPIKE
GLYCOPROTEIN,FIBRITI
N
(Homo
sapiens;
SARSr-CoV)		5 / 12
MET D 323
GLY B 488
GLN B 492
ILE D 379
PHE D 356
1.75A17.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6jyt HELICASE
(SARSr-CoV)		5 / 12
ALA A 454
SER A 453
VAL A 452
PHE A 472
ILE A 448
1.56A19.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6lxt SPIKE PROTEIN S2
(SARS-CoV-2)		5 / 12
ALA C 956
SER C1175
VAL A 951
ILE C1179
ASN C1178
1.63A19.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HGC_A_HCYA501_1
(SERPIN)		6lzg ACE2
(Homo
sapiens)		5 / 12
ALA A 311
THR A 334
ILE A 358
SER A 331
PHE A 308
1.58A20.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_E_HCYE900_1
(GLUCOCORTICOID
RECEPTOR)		6m17 ACE2
(Homo
sapiens)		5 / 12
GLY B 405
MET B 408
LEU B 410
GLN B 524
PHE B 400
1.53A16.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6m17 SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 12
SER C 206
VAL C 207
ILE C 133
ASN C 130
PHE C 425
1.67A20.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_2
(GLUCOCORTICOID
RECEPTOR)		6m18 SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		3 / 3
MET C 432
MET C 119
TYR C 128
1.17A18.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_G_HCYG900_2
(GLUCOCORTICOID
RECEPTOR)		6m18 SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		3 / 3
LEU A 201
MET A 137
TYR A 128
1.42A18.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HGC_A_HCYA501_1
(SERPIN)		6m18 SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 12
VAL C 317
ALA C 318
PHE C  74
PHE C  58
ASN C  54
1.41A19.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6m18 SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 12
SER C 143
ILE C 136
SER C 134
PHE C 400
TRP C 138
1.64A20.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6m18 SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 12
SER C 143
ILE C 136
SER C 134
PHE C 400
TRP C 138
1.56A19.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6m71 NSP12
NSP8
(SARS-CoV-2)		5 / 12
VAL B 131
THR A 394
ILE A 450
ASN A 447
SER A 451
1.55A20.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HGC_A_HCYA501_1
(SERPIN)		6m71 NSP12
(SARS-CoV-2)		5 / 12
VAL A 792
PRO A 620
ALA A 625
THR A 246
GLN A 698
1.73A17.73
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_C_HCYC1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6m71 NSP12
(SARS-CoV-2)		5 / 12
VAL A 764
THR A 769
ASN A 703
PHE A 766
HIS A 752
1.77A17.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_G_HCYG900_1
(GLUCOCORTICOID
RECEPTOR)		6m71 NSP12
(SARS-CoV-2)		5 / 12
ASN A 695
GLN A 789
MET A 626
MET A 633
ILE A 757
1.66A13.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_1
(GLUCOCORTICOID
RECEPTOR)		6m71 NSP12
(SARS-CoV-2)		5 / 12
ASN A 695
GLN A 789
MET A 626
MET A 633
ILE A 757
1.66A13.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_A_HCYA900_1
(GLUCOCORTICOID
RECEPTOR)		6m71 NSP12
(SARS-CoV-2)		5 / 12
MET A 666
GLY A 670
ARG A 392
ILE A 539
PHE A 504
1.65A13.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_D_HCYD1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6m71 NSP12
(SARS-CoV-2)		5 / 12
SER A 635
GLN A 357
ASN A 657
PHE A 652
HIS A 650
1.73A17.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6m71 NSP12
NSP8
(SARS-CoV-2)		5 / 12
ALA A 379
SER A 343
VAL A 341
THR B 123
ILE B 107
1.77A17.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_C_HCYC1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6m71 NSP12
(SARS-CoV-2)		5 / 12
SER A 635
GLN A 357
ASN A 657
PHE A 652
HIS A 650
1.70A17.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6m71 NSP12
NSP8
(SARS-CoV-2)		5 / 12
VAL B 131
THR A 394
ILE A 450
ASN A 447
SER A 451
1.50A20.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_A_HCYA900_1
(GLUCOCORTICOID
RECEPTOR)		6m71 NSP12
(SARS-CoV-2)		5 / 12
MET A 666
GLY A 670
LEU A 388
ILE A 539
PHE A 504
1.70A13.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_E_HCYE900_1
(GLUCOCORTICOID
RECEPTOR)		6m71 NSP12
(SARS-CoV-2)		5 / 12
LEU A 212
ASN A 213
GLY A 214
GLN A 210
LEU A 241
1.61A13.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_E_HCYE900_1
(GLUCOCORTICOID
RECEPTOR)		6m71 NSP12
(SARS-CoV-2)		5 / 12
LEU A 119
ASN A 213
GLY A 214
GLN A 210
MET A 124
1.66A13.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_G_HCYG900_2
(GLUCOCORTICOID
RECEPTOR)		6m71 NSP12
(SARS-CoV-2)		3 / 3
LEU A 895
MET A 906
TYR A 887
1.38A13.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6m71 NSP12
NSP8
(SARS-CoV-2)		5 / 12
ALA A 379
SER A 343
VAL A 330
ILE B 119
ASN B 118
1.68A17.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6m71 NSP12
(SARS-CoV-2)		5 / 12
ALA A  95
PRO A  94
VAL A  96
PHE A 222
PHE A 219
1.79A18.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_K_HCYK900_1
(GLUCOCORTICOID
RECEPTOR)		6m71 NSP12
(SARS-CoV-2)		5 / 12
ASN A 695
GLN A 789
MET A 626
MET A 633
ILE A 757
1.67A13.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_G_HCYG900_2
(GLUCOCORTICOID
RECEPTOR)		6m71 NSP12
(SARS-CoV-2)		3 / 3
LEU A 142
MET A 124
TYR A 788
1.78A13.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_A_HCYA900_1
(GLUCOCORTICOID
RECEPTOR)		6m71 NSP12
(SARS-CoV-2)		5 / 12
LEU A 212
ASN A 213
GLY A 214
GLN A 210
LEU A 241
1.68A13.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6m71 NSP12
NSP8
(SARS-CoV-2)		5 / 12
VAL B 131
THR A 394
ILE A 450
ASN A 447
SER A 451
1.48A20.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_1
(GLUCOCORTICOID
RECEPTOR)		6m71 NSP12
(SARS-CoV-2)		5 / 12
LEU A 212
ASN A 213
GLY A 214
GLN A 210
LEU A 241
1.72A13.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_A_HCYA900_1
(GLUCOCORTICOID
RECEPTOR)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
LEU A 994
LEU A 749
GLN A 992
THR C 991
ILE C 995
1.60A11.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
ALA B1060
PRO B1061
VAL B1076
PHE B1092
ILE B 696
1.67A15.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_G_HCYG900_2
(GLUCOCORTICOID
RECEPTOR)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		3 / 3
LEU C 986
MET C 722
TYR C 738
1.68A11.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_E_HCYE900_1
(GLUCOCORTICOID
RECEPTOR)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
LEU A 994
LEU A 749
GLN A 992
THR C 991
ILE C 995
1.57A11.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_G_HCYG900_1
(GLUCOCORTICOID
RECEPTOR)		6nb7 SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
ASN A 910
GLY A 781
LEU A 776
ILE A 913
PHE A 909
1.64A11.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_G_HCYG900_2
(GLUCOCORTICOID
RECEPTOR)		6nb8 S230 ANTIGEN-BINDING
(FAB) FRAGMENT,
HEAVY CHAIN
S230 ANTIGEN-BINDING
(FAB) FRAGMENT,
LIGHT CHAIN
(Homo
sapiens)		3 / 3
LEU H  45
MET H 114
TYR L  91
0.92A21.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6nb8 S230 ANTIGEN-BINDING
(FAB) FRAGMENT,
LIGHT CHAIN
(Homo
sapiens)		5 / 12
ALA L 135
SER L 136
VAL L 137
ASN L 163
HIS L 194
1.51A21.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6nur NSP12
(SARSr-CoV)		5 / 12
THR A 870
ILE A 864
ASN A 912
SER A 914
HIS A 882
1.71A17.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6nur NSP12
NSP8
(SARSr-CoV)		5 / 12
VAL B 131
THR A 394
ILE A 450
ASN A 447
SER A 451
1.31A20.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6nur NSP12
NSP8
(SARSr-CoV)		5 / 12
VAL B 131
THR A 394
ILE A 450
ASN A 447
SER A 451
1.39A19.73
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6nur NSP12
NSP8
(SARSr-CoV)		5 / 12
VAL B 131
THR A 394
ILE A 450
ASN A 447
SER A 451
1.34A20.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_K_HCYK900_1
(GLUCOCORTICOID
RECEPTOR)		6nur NSP12
(SARSr-CoV)		5 / 12
MET A 666
GLY A 670
ARG A 392
ILE A 539
PHE A 504
1.37A13.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_G_HCYG900_2
(GLUCOCORTICOID
RECEPTOR)		6nur NSP12
(SARSr-CoV)		3 / 3
LEU A 142
MET A 124
TYR A 788
1.69A13.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_A_HCYA900_1
(GLUCOCORTICOID
RECEPTOR)		6nur NSP12
(SARSr-CoV)		5 / 12
MET A 666
GLY A 670
ARG A 392
ILE A 539
PHE A 504
1.44A13.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6nus NSP12
(SARSr-CoV)		5 / 12
SER A 754
PHE A 480
ILE A 696
ASN A 695
SER A 692
1.48A17.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_1
(GLUCOCORTICOID
RECEPTOR)		6nus NSP12
(SARSr-CoV)		5 / 12
ASN A 695
GLN A 789
MET A 626
MET A 633
ILE A 757
1.46A13.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_G_HCYG900_1
(GLUCOCORTICOID
RECEPTOR)		6nus NSP12
(SARSr-CoV)		5 / 12
ASN A 695
GLN A 789
MET A 626
MET A 633
ILE A 757
1.45A13.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_E_HCYE900_1
(GLUCOCORTICOID
RECEPTOR)		6nus NSP12
(SARSr-CoV)		5 / 12
LEU A 212
ASN A 213
GLY A 214
GLN A 210
LEU A 241
1.61A13.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6nus NSP12
(SARSr-CoV)		5 / 12
SER A 754
PHE A 480
ILE A 696
ASN A 695
SER A 692
1.68A17.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_1
(GLUCOCORTICOID
RECEPTOR)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
LEU B 916
GLN B 901
THR B 881
ILE B 882
PHE B1052
1.55A11.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL C  47
GLN C 853
PHE C 855
ARG C  44
ILE B 569
1.76A15.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_G_HCYG900_1
(GLUCOCORTICOID
RECEPTOR)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
LEU A 916
GLN A 901
THR A 881
ILE A 882
PHE A1052
1.52A11.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_G_HCYG900_2
(GLUCOCORTICOID
RECEPTOR)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		3 / 3
LEU A1004
MET A 740
TYR A 756
1.70A11.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HGC_A_HCYA501_1
(SERPIN)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
PRO C 174
THR C 240
PHE C  92
SER C  94
ASN C 121
1.51A16.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_E_HCYE900_1
(GLUCOCORTICOID
RECEPTOR)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ASN B 317
GLY B 594
GLN B 613
LEU C 861
THR C 739
1.56A11.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL C  47
GLN C 853
PHE C 855
ARG C  44
ILE B 569
1.71A15.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ALA C 123
THR C 240
PHE C  92
ASN C 188
SER C  94
1.69A15.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_A_HCYA900_1
(GLUCOCORTICOID
RECEPTOR)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
MET A1050
LEU A1049
GLY A 908
LEU A 916
THR A 881
1.48A11.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_K_HCYK900_1
(GLUCOCORTICOID
RECEPTOR)		6vw1 ACE2
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
MET B 323
GLY F 502
GLN F 506
ILE B 379
PHE B 356
1.77A17.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_1
(GLUCOCORTICOID
RECEPTOR)		6vw1 ACE2
(Homo
sapiens)		5 / 12
LEU B 440
ASN B 437
GLN B 598
LEU B 595
ILE B 291
1.68A17.86
None
None
EDO  B 707 (-3.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6vww URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
ALA B  82
VAL B 122
THR B 115
ILE B 108
ASP B 107
1.75A20.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_1
(GLUCOCORTICOID
RECEPTOR)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
LEU C 916
GLN C 901
THR C 881
ILE C 882
PHE C1052
1.61A11.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ALA C1056
VAL C1061
THR C 941
ILE C 934
LYS C 825
1.71A14.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ALA A1056
SER A1055
VAL A1061
THR A 941
ILE A 934
1.47A15.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HGC_A_HCYA501_1
(SERPIN)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL B 126
PHE B 194
ILE B 203
SER B 205
ASN B 121
1.62A15.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_A_HCYA900_1
(GLUCOCORTICOID
RECEPTOR)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
MET B1050
LEU B1049
GLY B 908
LEU B 916
THR B 881
1.51A11.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_E_HCYE900_1
(GLUCOCORTICOID
RECEPTOR)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
LEU A 916
GLN A 901
THR A 881
ILE A 882
PHE A1052
1.63A11.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_G_HCYG900_2
(GLUCOCORTICOID
RECEPTOR)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		3 / 3
LEU A1004
MET A 740
TYR A 756
1.62A11.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_G_HCYG900_1
(GLUCOCORTICOID
RECEPTOR)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
LEU C 916
GLN C 901
THR C 881
ILE C 882
PHE C1052
1.59A11.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_G_HCYG900_1
(GLUCOCORTICOID
RECEPTOR)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
GLY C 971
GLN A 755
LEU A 753
GLN A1002
THR B 998
1.47A11.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_G_HCYG900_2
(GLUCOCORTICOID
RECEPTOR)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		3 / 3
LEU B1004
MET B 740
TYR B 756
1.62A11.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_1
(GLUCOCORTICOID
RECEPTOR)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
GLY C 971
GLN A 755
LEU A 753
GLN A1002
THR B 998
1.49A11.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ALA A1056
SER A1055
VAL A1061
THR A 941
ILE A 934
1.57A15.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_A_HCYA900_1
(GLUCOCORTICOID
RECEPTOR)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
MET B1050
LEU B1049
GLY B 908
LEU B 916
THR B 881
1.52A11.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_E_HCYE900_1
(GLUCOCORTICOID
RECEPTOR)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
LEU A 916
GLN A 901
THR A 881
ILE A 882
PHE A1052
1.61A11.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ALA B1056
VAL B1061
THR B 941
ILE B 934
LYS B 825
1.64A14.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6w01 URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
VAL B 319
PHE B 303
ILE B 306
PHE B 342
HIS B 250
1.73A24.11
None
None
None
None
CIT  B 408 (-3.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6w01 URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
VAL B 319
PHE B 303
ILE B 306
PHE B 342
HIS B 250
1.79A23.81
None
None
None
None
CIT  B 408 (-3.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_D_HCYD1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6w41 CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		5 / 12
SER L  65
GLN L 100
ILE L  21
ASN L  22
SER L   7
1.56A19.73
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6w41 CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		5 / 12
SER L  65
GLN L 100
ILE L  21
ASN L  22
SER L   7
1.52A18.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_C_HCYC1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6w41 CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		5 / 12
SER L  65
GLN L 100
ILE L  21
ASN L  22
SER L   7
1.56A19.73
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6w41 CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		5 / 12
ALA L 130
SER L 131
VAL L 132
ASN L 158
HIS L 189
1.53A19.73
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6w41 CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		5 / 12
SER L  65
GLN L 100
ILE L  21
ASN L  22
SER L   7
1.67A19.73
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_G_HCYG900_2
(GLUCOCORTICOID
RECEPTOR)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		3 / 3
LEU H  45
MET H  48
TYR L  91
1.71A21.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_A_HCYA900_1
(GLUCOCORTICOID
RECEPTOR)		6w41 CR3022 FAB HEAVY
CHAIN
(Homo
sapiens)		5 / 12
LEU H  80
GLN H  81
LEU H  18
GLN H   6
ILE H  34
1.62A21.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6w41 CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		5 / 12
SER L  65
GLN L 100
ILE L  21
ASN L  22
SER L   7
1.58A18.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HGC_A_HCYA501_1
(SERPIN)		6w41 CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		5 / 12
VAL L  58
ARG L  18
THR L  74
GLN L  79
SER L  77
1.74A19.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6w4h NSP16
(SARS-CoV-2)		5 / 12
SER A6907
VAL A6894
PHE A6954
ASN A6920
HIS A6917
1.71A25.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6w4h NSP16
(SARS-CoV-2)		5 / 12
ALA A6881
THR A6993
PHE A7003
ILE A6926
LYS A6844
1.73A24.74
None
None
None
None
ACT  A7103 ( 3.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6w4h NSP16
(SARS-CoV-2)		5 / 12
ALA A6976
THR A6934
ILE A6969
SER A7000
TRP A6974
1.52A25.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
ALA A6976
THR A6934
ILE A6969
SER A7000
TRP A6974
1.54A
None
KCX  A6935 ( 3.6A)
None
KCX  A6935 ( 3.7A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
ALA A6881
THR A6993
PHE A7003
ILE A6926
LYS A6844
1.77A
None
None
None
None
EDO  A7103 (-3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6w75 NSP16
(SARS-CoV-2)		5 / 12
ALA C6881
THR C6993
PHE C7003
ILE C6926
LYS C6844
1.73A19.09
None
None
None
None
FMT  C7108 ( 4.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_D_HCYD1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6w75 NSP16
(SARS-CoV-2)		5 / 12
SER C6907
VAL C6894
PHE C6954
ASN C6920
HIS C6917
1.74A20.00
None
None
None
FMT  C7106 ( 4.1A)
FMT  C7113 ( 4.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_1
(GLUCOCORTICOID
RECEPTOR)		6w75 NSP16
(SARS-CoV-2)		5 / 12
LEU A6909
GLY A6911
MET A6929
THR A6880
PHE A6901
1.60A20.24
None
None
SAM  A7102 ( 3.5A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6w75 NSP16
(SARS-CoV-2)		5 / 12
ALA C6960
PHE C6868
ARG C6864
ILE C6866
PHE C6954
1.79A19.09
None
None
FMT  C7106 ( 2.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_1
(GLUCOCORTICOID
RECEPTOR)		6w75 NSP16
(SARS-CoV-2)		5 / 12
LEU C6909
GLY C6911
MET C6929
THR C6880
PHE C6901
1.60A20.24
None
NA  C7104 ( 4.1A)
SAM  C7105 ( 3.5A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_C_HCYC1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6w75 NSP16
(SARS-CoV-2)		5 / 12
THR A6934
ILE A6969
SER A7000
HIS A6972
TRP A6974
1.78A20.00
FMT  A7103 ( 4.4A)
None
FMT  A7105 ( 2.6A)
FMT  A7103 ( 4.2A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6w75 NSP16
(SARS-CoV-2)		5 / 12
ALA A6881
THR A6993
PHE A7003
ILE A6926
LYS A6844
1.74A19.09
None
None
None
None
FMT  A7104 ( 4.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_A_HCYA900_1
(GLUCOCORTICOID
RECEPTOR)		6w75 NSP16
(SARS-CoV-2)		5 / 12
LEU C6909
GLY C6911
MET C6929
THR C6880
PHE C6901
1.62A20.24
None
NA  C7104 ( 4.1A)
SAM  C7105 ( 3.5A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_E_HCYE900_1
(GLUCOCORTICOID
RECEPTOR)		6w75 NSP16
(SARS-CoV-2)		5 / 12
LEU C6909
GLY C6911
MET C6929
THR C6880
PHE C6901
1.62A20.24
None
NA  C7104 ( 4.1A)
SAM  C7105 ( 3.5A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6w75 NSP10
(SARS-CoV-2)		5 / 12
ALA D4276
VAL B4274
ILE B4334
ASP D4335
LYS D4271
1.77A17.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6w75 NSP16
(SARS-CoV-2)		5 / 12
ALA A6960
PHE A6868
ARG A6864
ILE A6866
PHE A6954
1.80A19.09
None
None
FMT  A7106 ( 2.6A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_C_HCYC1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6w75 NSP16
(SARS-CoV-2)		5 / 12
SER C6907
VAL C6894
PHE C6954
ASN C6920
HIS C6917
1.75A20.00
None
None
None
FMT  C7106 ( 4.1A)
FMT  C7113 ( 4.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6w75 NSP16
(SARS-CoV-2)		5 / 12
ALA A6976
THR A6934
ILE A6969
SER A7000
TRP A6974
1.57A20.00
None
FMT  A7103 ( 4.4A)
None
FMT  A7105 ( 2.6A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HGC_A_HCYA501_1
(SERPIN)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
VAL B 270
ALA B 264
THR D 296
GLN B 294
ASN B 269
1.72A16.49
None
None
CL  D 401 ( 4.6A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
ALA A6881
THR A6993
PHE A7003
ILE A6926
LYS A6844
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
ALA A6976
THR A6934
ILE A6969
SER A7000
TRP A6974
1.56A
FMT  A7108 ( 3.9A)
FMT  A7103 (-4.6A)
None
FMT  A7104 ( 2.9A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6wjt NSP10
(SARS-CoV-2)		5 / 12
ALA D4276
VAL B4274
ILE B4334
ASP D4335
LYS D4271
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6wjt NSP10
(SARS-CoV-2)		5 / 12
ALA B4276
VAL D4274
ILE D4334
ASP B4335
LYS B4271
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
ALA C6881
THR C6993
PHE C7003
ILE C6926
LYS C6844
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
ALA C6960
PHE C6868
ARG C6864
ILE C6866
PHE C6954
1.76A
None
None
FMT  C7103 (-2.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
ALA A6960
PHE A6868
ARG A6864
ILE A6866
PHE A6954
1.79A
None
None
FMT  A7106 (-2.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_C_HCYC1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
THR C6934
ILE C6969
SER C7000
HIS C6972
TRP C6974
1.71A25.00
FMT  C7104 (-4.2A)
None
FMT  C7104 ( 3.7A)
FMT  C7104 (-4.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
ALA C6976
THR C6934
ILE C6969
SER C7000
TRP C6974
1.58A
None
FMT  C7104 (-4.2A)
None
FMT  C7104 ( 3.7A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
VAL D 158
THR D  57
ASN A  75
SER A  78
HIS A 145
1.68A16.89
None
ZN  A 201 ( 4.4A)
None
None
ZN  A 201 (-3.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_C_HCYC1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6wkq NSP16
(SARS-CoV-2)		5 / 12
SER C6907
VAL C6894
PHE C6954
ASN C6920
HIS C6917
1.73A25.00
None
None
None
FMT  C7106 ( 4.1A)
FMT  C7108 ( 4.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6wkq NSP16
(SARS-CoV-2)		5 / 12
ALA A6881
THR A6993
PHE A7003
ILE A6926
LYS A6844
1.73A
None
None
None
None
FMT  A7104 ( 4.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6wkq NSP16
(SARS-CoV-2)		5 / 12
ALA C6976
THR C6934
ILE C6969
SER C7000
TRP C6974
1.54A
None
FMT  C7104 ( 4.7A)
None
FMT  C7110 ( 3.0A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_C_HCYC1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6wkq NSP16
(SARS-CoV-2)		5 / 12
THR A6934
ILE A6969
SER A7000
HIS A6972
TRP A6974
1.79A25.00
FMT  A7105 ( 4.6A)
None
FMT  A7106 ( 2.8A)
FMT  A7105 ( 4.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_D_HCYD1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6wkq NSP16
(SARS-CoV-2)		5 / 12
SER C6907
VAL C6894
PHE C6954
ASN C6920
HIS C6917
1.72A25.00
None
None
None
FMT  C7106 ( 4.1A)
FMT  C7108 ( 4.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6wkq NSP16
(SARS-CoV-2)		5 / 12
ALA A6960
PHE A6868
ARG A6864
ILE A6866
PHE A6954
1.80A
None
None
FMT  A7109 ( 2.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6wkq NSP16
(SARS-CoV-2)		5 / 12
ALA A6976
THR A6934
ILE A6969
SER A7000
TRP A6974
1.55A
None
FMT  A7105 ( 4.6A)
None
FMT  A7106 ( 2.8A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_1
(GLUCOCORTICOID
RECEPTOR)		6wkq NSP16
(SARS-CoV-2)		5 / 12
LEU A6909
GLY A6911
MET A6929
THR A6880
PHE A6901
1.60A21.61
None
NA  A7102 ( 4.2A)
SFG  A7103 ( 3.5A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6wkq NSP16
(SARS-CoV-2)		5 / 12
ALA C6960
PHE C6868
ARG C6864
ILE C6866
PHE C6954
1.76A
None
None
FMT  C7106 ( 2.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6wkq NSP16
(SARS-CoV-2)		5 / 12
ALA C6881
THR C6993
PHE C7003
ILE C6926
LYS C6844
1.73A
None
None
None
None
FMT  C7112 ( 4.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6wkq NSP10
(SARS-CoV-2)		5 / 12
ALA D4276
VAL B4274
ILE B4334
ASP D4335
LYS D4271
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_1
(GLUCOCORTICOID
RECEPTOR)		6wkq NSP16
(SARS-CoV-2)		5 / 12
LEU C6909
GLY C6911
MET C6929
THR C6880
PHE C6901
1.61A21.61
None
NA  C7102 ( 4.2A)
SFG  C7103 ( 3.5A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
VAL A 319
PHE A 303
ILE A 306
PHE A 342
HIS A 250
1.78A
None
None
None
None
U5P  A 401 (-4.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
SER B 294
VAL B 295
PHE B 241
ILE B 281
SER B 288
1.74A22.00
U5P  B 401 (-2.7A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
VAL B 319
PHE B 303
ILE B 306
PHE B 342
HIS B 250
1.74A22.00
None
None
None
None
U5P  B 401 (-4.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
SER A 329
VAL A 319
PHE A 303
ILE A 306
PHE A 342
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_C_HCYC1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
VAL B 319
PHE B 303
ILE B 306
PHE B 342
HIS B 250
1.76A22.00
None
None
None
None
U5P  B 401 (-4.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
VAL A 319
PHE A 303
ILE A 306
PHE A 342
HIS A 250
1.74A22.00
None
None
None
None
U5P  A 401 (-4.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
VAL B 319
PHE B 303
ILE B 306
PHE B 342
HIS B 250
1.78A
None
None
None
None
U5P  B 401 (-4.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_C_HCYC1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
SER A 329
VAL A 319
ILE A 306
PHE A 342
HIS A 250
1.76A22.00
None
None
None
None
U5P  A 401 (-4.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
VAL A 319
PHE A 303
ILE A 306
PHE A 342
HIS A 250
1.80A22.14
None
None
None
None
U5P  A 401 (-4.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_D_HCYD1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
SER B 294
VAL B 295
PHE B 241
ILE B 281
SER B 288
1.68A22.00
U5P  B 401 (-2.7A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_D_HCYD1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
SER A 294
VAL A 295
PHE A 241
ILE A 281
SER A 288
1.66A22.00
U5P  A 401 (-2.7A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
ALA B  82
VAL B 122
THR B 115
ILE B 108
ASP B 107
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_C_HCYC1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
VAL A 319
PHE A 303
ILE A 306
PHE A 342
HIS A 250
1.75A22.00
None
None
None
None
U5P  A 401 (-4.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
SER A 294
VAL A 295
PHE A 241
ILE A 281
SER A 288
1.72A22.00
U5P  A 401 (-2.7A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
ALA A6976
THR A6934
ILE A6969
SER A7000
TRP A6974
1.52A
None
None
None
GTA  A7102 (-2.6A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_C_HCYC1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
THR A6934
ILE A6969
SER A7000
HIS A6972
TRP A6974
1.71A25.00
None
None
GTA  A7102 (-2.6A)
GTA  A7102 (-4.2A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_D_HCYD1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
SER A6907
VAL A6894
GLN A6957
ASN A6920
HIS A6917
1.68A25.00
None
None
None
SO4  A7106 (-4.1A)
SO4  A7105 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_C_HCYC1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
SER A6907
VAL A6894
PHE A6954
ASN A6920
HIS A6917
1.75A25.00
None
None
None
SO4  A7106 (-4.1A)
SO4  A7105 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_1
(GLUCOCORTICOID
RECEPTOR)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
LEU A7037
GLY A6829
GLN A6847
MET A6840
ILE A7035
1.70A21.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_1
(GLUCOCORTICOID
RECEPTOR)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
LEU A7037
ASN A6827
GLY A6829
MET A6840
ILE A7035
1.76A21.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
ALA A6881
THR A6993
PHE A7003
ILE A6926
LYS A6844
1.74A
None
None
None
None
GTA  A7102 (-2.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
SER A6907
VAL A6894
PHE A6954
ASN A6920
HIS A6917
1.76A24.81
None
None
None
SO4  A7106 (-4.1A)
SO4  A7105 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_C_HCYC1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
SER A6907
VAL A6894
GLN A6957
ASN A6920
HIS A6917
1.66A25.00
None
None
None
SO4  A7106 (-4.1A)
SO4  A7105 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_E_HCYE900_1
(GLUCOCORTICOID
RECEPTOR)		6wrh PEPTIDASE C16
(SARS-CoV-2)		5 / 12
LEU A 117
LEU A 172
GLN A 122
THR A 277
ILE A 285
1.72A22.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
ALA B 152
SER B 151
THR B 187
PHE B 147
TRP B 154
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_1
(GLUCOCORTICOID
RECEPTOR)		6yi3 NUCLEOPROTEIN
(SARS-CoV-2)		5 / 12
LEU A 119
GLY A 135
ARG A  67
THR A  36
ILE A  34
1.41A20.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_E_HCYE900_1
(GLUCOCORTICOID
RECEPTOR)		6yi3 NUCLEOPROTEIN
(SARS-CoV-2)		5 / 12
LEU A 119
GLY A 135
ARG A  67
THR A  36
ILE A  34
1.42A20.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6yi3 NUCLEOPROTEIN
(SARS-CoV-2)		5 / 12
SER A  11
ARG A 109
ILE A 106
ASN A  37
SER A  38
1.79A17.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_A_HCYA900_1
(GLUCOCORTICOID
RECEPTOR)		6yi3 NUCLEOPROTEIN
(SARS-CoV-2)		5 / 12
LEU A 119
GLY A 135
ARG A  67
THR A  36
ILE A  34
1.43A20.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6yla LIGHT CHAIN
(Homo
sapiens)		5 / 12
SER L  71
GLN L 106
ILE L  21
ASN L  22
SER L   7
1.52A21.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6yla LIGHT CHAIN
(Homo
sapiens)		5 / 12
SER L  69
GLN L 106
ILE L  21
ASN L  22
SER L   7
1.71A18.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6yla LIGHT CHAIN
(Homo
sapiens)		5 / 12
ALA L  57
SER L  71
GLN L 106
ILE L  21
ASN L  22
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6yla LIGHT CHAIN
(Homo
sapiens)		5 / 12
ALA C  57
GLN C 106
ILE C  21
ASN C  22
SER C   7
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_A_HCYA900_1
(GLUCOCORTICOID
RECEPTOR)		6yla HEAVY CHAIN
(Homo
sapiens)		5 / 12
LEU H  81
GLN H  82
LEU H  18
GLN H   6
ILE H  34
1.62A22.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6yla LIGHT CHAIN
(Homo
sapiens)		5 / 12
SER C  71
GLN C 106
ILE C  21
ASN C  22
SER C   7
1.42A18.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6yla LIGHT CHAIN
(Homo
sapiens)		5 / 12
SER C  69
GLN C 106
ILE C  21
ASN C  22
SER C   7
1.78A18.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_A_HCYA900_1
(GLUCOCORTICOID
RECEPTOR)		6yla HEAVY CHAIN
(Homo
sapiens)		5 / 12
LEU B  81
GLN B  82
LEU B  18
GLN B   6
ILE B  34
1.52A22.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6yla LIGHT CHAIN
(Homo
sapiens)		5 / 12
SER C  71
GLN C 106
ILE C  21
ASN C  22
SER C   7
1.45A18.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_C_HCYC1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6yla LIGHT CHAIN
(Homo
sapiens)		5 / 12
SER C  71
GLN C 106
ILE C  21
ASN C  22
SER C   7
1.44A21.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6yla LIGHT CHAIN
(Homo
sapiens)		5 / 12
SER L  71
GLN L 106
ILE L  21
ASN L  22
SER L   7
1.47A18.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6yla LIGHT CHAIN
(Homo
sapiens)		5 / 12
ALA L  57
GLN L 106
ILE L  21
ASN L  22
SER L   7
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_C_HCYC1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6yla LIGHT CHAIN
(Homo
sapiens)		5 / 12
SER L  71
GLN L 106
ILE L  21
ASN L  22
SER L   7
1.47A21.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_D_HCYD1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6yla LIGHT CHAIN
(Homo
sapiens)		5 / 12
SER C  71
GLN C 106
ILE C  21
ASN C  22
SER C   7
1.48A21.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6yla LIGHT CHAIN
(Homo
sapiens)		5 / 12
ALA C  57
SER C  71
GLN C 106
ILE C  21
ASN C  22
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6yla LIGHT CHAIN
(Homo
sapiens)		5 / 12
SER L  69
GLN L 106
ILE L  21
ASN L  22
SER L   7
1.80A21.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_D_HCYD1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6yla LIGHT CHAIN
(Homo
sapiens)		5 / 12
SER L  69
GLN L 106
ILE L  21
ASN L  22
SER L   7
1.78A21.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_D_HCYD1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6yla LIGHT CHAIN
(Homo
sapiens)		5 / 12
SER C  69
GLN C 106
ILE C  21
ASN C  22
SER C   7
1.80A21.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_D_HCYD1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6yla LIGHT CHAIN
(Homo
sapiens)		5 / 12
SER L  71
GLN L 106
ILE L  21
ASN L  22
SER L   7
1.51A21.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6yla LIGHT CHAIN
(Homo
sapiens)		5 / 12
SER C  69
GLN C 106
ILE C  21
ASN C  22
SER C   7
1.75A18.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6yla LIGHT CHAIN
(Homo
sapiens)		5 / 12
SER L  71
GLN L 106
ILE L  21
ASN L  22
SER L   7
1.42A18.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6yla LIGHT CHAIN
(Homo
sapiens)		5 / 12
SER C  71
GLN C 106
ILE C  21
ASN C  22
SER C   7
1.50A21.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_D_HCYD1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		5 / 12
SER L 183
THR L 178
SER L 120
PHE L 145
HIS H 168
1.73A21.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6yla LIGHT CHAIN
(Homo
sapiens)		5 / 12
ALA C 136
SER C 137
VAL C 138
ASN C 164
HIS C 195
1.54A
None
None
None
None
MLI  C 305 (-3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_C_HCYC1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6yla LIGHT CHAIN
(Homo
sapiens)		5 / 12
SER L  69
GLN L 106
ILE L  21
ASN L  22
SER L   7
1.79A21.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6yla LIGHT CHAIN
(Homo
sapiens)		5 / 12
SER L  69
GLN L 106
ILE L  21
ASN L  22
SER L   7
1.76A18.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6yla LIGHT CHAIN
(Homo
sapiens)		5 / 12
ALA L 136
SER L 137
VAL L 138
ASN L 164
HIS L 195
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_A_HCYA900_1
(GLUCOCORTICOID
RECEPTOR)		6ym0 HEAVY CHAIN
(Homo
sapiens)		5 / 12
LEU H  81
GLN H  82
LEU H  18
GLN H   6
ILE H  34
1.59A21.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_D_HCYD1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6ym0 LIGHT CHAIN
(Homo
sapiens)		5 / 12
SER L  71
GLN L 106
ILE L  21
ASN L  22
SER L   7
1.46A21.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6ym0 LIGHT CHAIN
(Homo
sapiens)		5 / 12
SER L  71
GLN L 106
ILE L  21
ASN L  22
SER L   7
1.44A18.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6ym0 LIGHT CHAIN
(Homo
sapiens)		5 / 12
SER L  71
GLN L 106
ILE L  21
ASN L  22
SER L   7
1.44A18.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_C_HCYC1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6ym0 LIGHT CHAIN
(Homo
sapiens)		5 / 12
SER L  71
GLN L 106
ILE L  21
ASN L  22
SER L   7
1.43A21.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6ym0 LIGHT CHAIN
(Homo
sapiens)		5 / 12
SER L  71
GLN L 106
ILE L  21
ASN L  22
SER L   7
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6ym0 LIGHT CHAIN
(Homo
sapiens)		5 / 12
ALA L 136
SER L 137
VAL L 138
ASN L 164
HIS L 195
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6ym0 LIGHT CHAIN
(Homo
sapiens)		5 / 12
SER L  69
GLN L 106
ILE L  21
ASN L  22
SER L   7
1.75A18.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_D_HCYD1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6ym0 LIGHT CHAIN
(Homo
sapiens)		5 / 12
SER L  69
GLN L 106
ILE L  21
ASN L  22
SER L   7
1.79A21.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6ym0 LIGHT CHAIN
(Homo
sapiens)		5 / 12
SER L  69
GLN L 106
ILE L  21
ASN L  22
SER L   7
1.79A18.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6ym0 LIGHT CHAIN
(Homo
sapiens)		5 / 12
SER L  71
GLN L 106
ILE L  21
ASN L  22
SER L   7
1.49A21.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6yor IGG L CHAIN
(Homo
sapiens)		5 / 12
ALA L 136
SER L 137
VAL L 138
ASN L 164
HIS L 195
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6yor IGG L CHAIN
(Homo
sapiens)		5 / 12
SER C  69
GLN C 106
ILE C  21
ASN C  22
SER C   7
1.70A18.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6yor IGG L CHAIN
(Homo
sapiens)		5 / 12
SER L  71
GLN L 106
ILE L  21
ASN L  22
SER L   7
1.52A21.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6yor IGG L CHAIN
(Homo
sapiens)		5 / 12
SER C  69
GLN C 106
ILE C  21
ASN C  22
SER C   7
1.79A21.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6yor IGG L CHAIN
(Homo
sapiens)		5 / 12
ALA C  57
GLN C 106
ILE C  21
ASN C  22
SER C   7
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6yor IGG L CHAIN
(Homo
sapiens)		5 / 12
SER C  71
GLN C 106
ILE C  21
ASN C  22
SER C   7
1.41A18.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_C_HCYC1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6yor IGG L CHAIN
(Homo
sapiens)		5 / 12
SER C  71
GLN C 106
ILE C  21
ASN C  22
SER C   7
1.47A21.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6yor IGG L CHAIN
(Homo
sapiens)		5 / 12
ALA C 136
SER C 137
VAL C 138
ASN C 164
HIS C 195
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6yor IGG L CHAIN
(Homo
sapiens)		5 / 12
SER C  71
GLN C 106
ILE C  21
ASN C  22
SER C   7
1.47A18.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_C_HCYC1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6yor IGG L CHAIN
(Homo
sapiens)		5 / 12
SER C  69
GLN C 106
ILE C  21
ASN C  22
SER C   7
1.78A21.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6yor IGG L CHAIN
(Homo
sapiens)		5 / 12
SER C  71
GLN C 106
ILE C  21
ASN C  22
SER C   7
1.52A21.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6yor IGG L CHAIN
(Homo
sapiens)		5 / 12
SER C  69
GLN C 106
ILE C  21
ASN C  22
SER C   7
1.75A18.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6yor IGG L CHAIN
(Homo
sapiens)		5 / 12
ALA L  57
SER L  71
GLN L 106
ILE L  21
ASN L  22
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_D_HCYD1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		5 / 12
SER C 183
THR C 178
SER C 120
PHE C 145
HIS B 168
1.73A21.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6yor IGG L CHAIN
(Homo
sapiens)		5 / 12
SER L  69
GLN L 106
ILE L  21
ASN L  22
SER L   7
1.80A21.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_D_HCYD1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6yor IGG L CHAIN
(Homo
sapiens)		5 / 12
SER C  69
GLN C 106
ILE C  21
ASN C  22
SER C   7
1.77A21.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_C_HCYC1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6yor IGG L CHAIN
(Homo
sapiens)		5 / 12
SER L  69
GLN L 106
ILE L  21
ASN L  22
SER L   7
1.79A21.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_D_HCYD1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		5 / 12
SER L 183
THR L 178
SER L 120
PHE L 145
HIS H 168
1.72A21.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6yor IGG L CHAIN
(Homo
sapiens)		5 / 12
SER L  69
GLN L 106
ILE L  21
ASN L  22
SER L   7
1.76A18.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_D_HCYD1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6yor IGG L CHAIN
(Homo
sapiens)		5 / 12
SER L  71
GLN L 106
ILE L  21
ASN L  22
SER L   7
1.51A21.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6yor IGG L CHAIN
(Homo
sapiens)		5 / 12
SER L  71
GLN L 106
ILE L  21
ASN L  22
SER L   7
1.46A18.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_C_HCYC1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6yor IGG L CHAIN
(Homo
sapiens)		5 / 12
SER L  71
GLN L 106
ILE L  21
ASN L  22
SER L   7
1.47A21.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6yor IGG L CHAIN
(Homo
sapiens)		5 / 12
SER L  69
GLN L 106
ILE L  21
ASN L  22
SER L   7
1.71A18.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6yor IGG L CHAIN
(Homo
sapiens)		5 / 12
ALA L  57
GLN L 106
ILE L  21
ASN L  22
SER L   7
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6yor IGG L CHAIN
(Homo
sapiens)		5 / 12
SER L  71
GLN L 106
ILE L  21
ASN L  22
SER L   7
1.41A18.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_D_HCYD1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6yor IGG L CHAIN
(Homo
sapiens)		5 / 12
SER L  69
GLN L 106
ILE L  21
ASN L  22
SER L   7
1.79A21.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_A_HCYA900_1
(GLUCOCORTICOID
RECEPTOR)		6yor IGG H CHAIN
(Homo
sapiens)		5 / 12
LEU H  81
GLN H  82
LEU H  18
GLN H   6
ILE H  34
1.62A22.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_D_HCYD1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6yor IGG L CHAIN
(Homo
sapiens)		5 / 12
SER C  71
GLN C 106
ILE C  21
ASN C  22
SER C   7
1.51A21.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6yor IGG L CHAIN
(Homo
sapiens)		5 / 12
ALA C  57
SER C  71
GLN C 106
ILE C  21
ASN C  22
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_A_HCYA900_1
(GLUCOCORTICOID
RECEPTOR)		6yor IGG H CHAIN
(Homo
sapiens)		5 / 12
LEU B  81
GLN B  82
LEU B  18
GLN B   6
ILE B  34
1.62A22.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_C_HCYC1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
SER E 128
PHE B 132
ILE B 131
ASN E 101
HIS B  45
1.77A19.05
EPE  E 202 (-4.6A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_A_HCYA900_1
(GLUCOCORTICOID
RECEPTOR)		7btf NSP12
(SARS-CoV-2)		5 / 12
MET A 666
GLY A 670
ARG A 392
ILE A 539
PHE A 504
1.51A13.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_A_HCYA900_1
(GLUCOCORTICOID
RECEPTOR)		7btf NSP12
(SARS-CoV-2)		5 / 12
LEU A 212
ASN A 213
GLY A 214
GLN A 210
LEU A 241
1.76A13.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_E_HCYE900_1
(GLUCOCORTICOID
RECEPTOR)		7btf NSP12
(SARS-CoV-2)		5 / 12
LEU A 212
ASN A 213
GLY A 214
GLN A 210
LEU A 241
1.71A13.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		7btf NSP12
NSP8
(SARS-CoV-2)		5 / 12
ALA A 379
SER A 343
VAL A 330
ILE B 119
ASN B 118
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_D_HCYD1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		7btf NSP12
(SARS-CoV-2)		5 / 12
SER A 635
GLN A 357
ASN A 657
PHE A 652
HIS A 650
1.72A17.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_D_HCYD1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		7btf NSP12
(SARS-CoV-2)		5 / 12
VAL A 330
GLN A 661
THR A 538
ARG A 331
ASN A 356
1.76A17.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		7btf NSP12
NSP8
(SARS-CoV-2)		5 / 12
VAL B 131
THR A 394
ILE A 450
ASN A 447
SER A 451
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		7btf NSP12
NSP8
(SARS-CoV-2)		5 / 12
ALA A 379
SER A 343
VAL A 341
THR B 123
ILE B 107
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		7btf NSP12
NSP8
(SARS-CoV-2)		5 / 12
VAL B 131
THR A 394
ILE A 450
ASN A 447
SER A 451
1.47A20.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_C_HCYC1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		7btf NSP12
NSP8
(SARS-CoV-2)		5 / 12
VAL B 131
THR A 394
ILE A 450
ASN A 447
SER A 451
1.41A20.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		7btf NSP12
(SARS-CoV-2)		5 / 12
ALA A 634
SER A 635
THR A 586
ILE A 579
PHE A 480
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		7btf NSP12
NSP8
(SARS-CoV-2)		5 / 12
VAL B 131
THR A 394
ILE A 450
ASN A 447
SER A 451
1.43A20.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_C_HCYC1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		7btf NSP12
(SARS-CoV-2)		5 / 12
SER A 635
GLN A 357
ASN A 657
PHE A 652
HIS A 650
1.67A17.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_E_HCYE900_1
(GLUCOCORTICOID
RECEPTOR)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
LEU A 119
ASN A 213
GLY A 214
GLN A 210
MET A 124
1.67A13.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_D_HCYD1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		7bv1 NSP12
NSP8
(SARS-CoV-2)		5 / 12
SER A 343
VAL A 330
THR B 124
ILE B 119
ASN B 118
1.76A17.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_A_HCYA900_1
(GLUCOCORTICOID
RECEPTOR)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
LEU A 212
ASN A 213
GLY A 214
GLN A 210
LEU A 241
1.75A13.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		7bv1 NSP8
(SARS-CoV-2)		5 / 12
ALA D 152
SER D 151
THR D 187
PHE D 147
TRP D 154
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
ALA A 634
SER A 635
THR A 586
ILE A 579
PHE A 480
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_E_HCYE900_1
(GLUCOCORTICOID
RECEPTOR)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
LEU A 212
ASN A 213
GLY A 214
GLN A 210
LEU A 241
1.70A13.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_1
(GLUCOCORTICOID
RECEPTOR)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
LEU A 708
GLN A 468
LEU A 240
ARG A 132
PHE A 741
1.57A13.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_C_HCYC1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		7bv1 NSP12
NSP8
(SARS-CoV-2)		5 / 12
VAL B 131
THR A 394
ILE A 450
ASN A 447
SER A 451
1.45A20.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_A_HCYA900_1
(GLUCOCORTICOID
RECEPTOR)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
LEU A 708
GLN A 468
LEU A 240
ARG A 132
PHE A 741
1.55A13.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_A_HCYA900_1
(GLUCOCORTICOID
RECEPTOR)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
MET A 666
GLY A 670
ARG A 392
ILE A 539
PHE A 504
1.35A13.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_E_HCYE900_1
(GLUCOCORTICOID
RECEPTOR)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
LEU A 708
GLN A 468
LEU A 240
ARG A 132
PHE A 741
1.53A13.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
ALA A  95
PRO A  94
VAL A  96
PHE A 222
PHE A 219
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		7bv1 NSP12
NSP8
(SARS-CoV-2)		5 / 12
ALA A 379
SER A 343
VAL A 341
THR B 123
ILE B 107
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
ALA A  95
PRO A  94
VAL A  96
GLN A 224
PHE A 219
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
SER A 239
PHE A 317
ASN A 312
PHE A 287
TRP A 290
1.68A17.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_C_HCYC1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
SER A 635
GLN A 357
ASN A 657
PHE A 652
HIS A 650
1.50A17.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_K_HCYK900_1
(GLUCOCORTICOID
RECEPTOR)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
MET A 666
GLY A 670
ARG A 392
ILE A 539
PHE A 504
1.32A13.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
ALA A 656
VAL A 354
PHE A 326
ASN A 314
SER A 318
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_D_HCYD1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
SER A 635
GLN A 357
ASN A 657
PHE A 652
HIS A 650
1.54A17.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		7bv1 NSP12
NSP8
(SARS-CoV-2)		5 / 12
ALA A 379
SER A 343
VAL A 330
ILE B 119
ASN B 118
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		7bv1 NSP12
NSP8
(SARS-CoV-2)		5 / 12
VAL B 131
THR A 394
ILE A 450
ASN A 447
SER A 451
1.47A20.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		7bv1 NSP12
NSP8
(SARS-CoV-2)		5 / 12
VAL B 131
THR A 394
ILE A 450
ASN A 447
SER A 451
1.40A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_A_HCYA900_1
(GLUCOCORTICOID
RECEPTOR)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
MET A 666
GLY A 670
LEU A 388
ILE A 539
PHE A 504
1.62A13.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_C_HCYC1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		7bv2 NSP12
NSP8
(SARS-CoV-2)		5 / 12
SER A 343
VAL A 330
THR B 124
ILE B 119
ASN B 118
1.66A17.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
ALA A  95
PRO A  94
VAL A  96
PHE A 222
PHE A 219
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_E_HCYE900_1
(GLUCOCORTICOID
RECEPTOR)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
LEU A 708
GLN A 468
LEU A 240
ARG A 132
PHE A 741
1.70A13.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_D_HCYD1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
VAL A 330
GLN A 661
THR A 538
ARG A 331
ASN A 356
1.78A17.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
ALA A 634
SER A 635
THR A 586
ILE A 579
PHE A 480
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_D_HCYD1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
SER A 635
GLN A 357
ASN A 657
PHE A 652
HIS A 650
1.56A17.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		7bv2 NSP12
NSP8
(SARS-CoV-2)		5 / 12
ALA A 379
SER A 343
VAL A 341
THR B 123
ILE B 107
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		7bv2 NSP12
NSP8
(SARS-CoV-2)		5 / 12
VAL B 131
THR A 394
ILE A 450
ASN A 447
SER A 451
1.32A20.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		7bv2 NSP12
NSP8
(SARS-CoV-2)		5 / 12
VAL B 131
THR A 394
ILE A 450
ASN A 447
SER A 451
1.35A19.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_A_HCYA900_1
(GLUCOCORTICOID
RECEPTOR)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
LEU A 708
GLN A 468
LEU A 240
ARG A 132
PHE A 741
1.71A13.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
SER A 239
PHE A 317
ASN A 312
PHE A 287
TRP A 290
1.66A17.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_C_HCYC1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		7bv2 NSP12
NSP8
(SARS-CoV-2)		5 / 12
VAL B 131
THR A 394
ILE A 450
ASN A 447
SER A 451
1.31A20.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		7bv2 NSP12
NSP8
(SARS-CoV-2)		5 / 12
VAL B 131
THR A 394
ILE A 450
ASN A 447
SER A 451
1.51A19.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		7bv2 NSP12
NSP8
(SARS-CoV-2)		5 / 12
VAL B 131
THR A 394
ILE A 450
ASN A 447
SER A 451
1.27A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_C_HCYC1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
SER A 635
GLN A 357
ASN A 657
PHE A 652
HIS A 650
1.55A17.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_D_HCYD1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		7bv2 NSP12
NSP8
(SARS-CoV-2)		5 / 12
VAL B 131
THR A 394
ILE A 450
ASN A 447
SER A 451
1.42A20.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		7bv2 NSP12
NSP8
(SARS-CoV-2)		5 / 12
ALA A 379
SER A 343
VAL A 330
ILE B 119
ASN B 118
1.69A
None