Ligand ID: H8J


Drugbank ID:
DB00247
(Methysergide)


Indication:
For the treatment of vascular headache

Get human targets for H8J in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'H8J'

Click here for results that match SARS-Cov-2 / COVID-19 structures only
Click here for results that match SARS-related structures only


1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		1q2w 3C-LIKE PROTEASE
(SARSr-CoV)		6 / 12
VAL A  42
THR A  25
LEU A  89
PHE A  66
GLY A  23
VAL A  18
1.59A20.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		1qz8 POLYPROTEIN 1AB
(SARSr-CoV)		6 / 12
VAL A 102
SER A 105
LEU A  88
PHE A  90
GLY B 100
VAL A 110
1.64A14.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		1z1j 3C-LIKE PROTEINASE
(SARSr-CoV)		6 / 12
VAL B1042
THR B1025
LEU B1089
PHE B1066
GLY B1023
VAL B1018
1.46A20.73
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		2amd 3C-LIKE PROTEINASE
(SARSr-CoV)		6 / 12
VAL A  42
THR A  25
LEU A  89
PHE A  66
GLY A  23
VAL A  18
1.54A20.96
None
9IN  A1001 (-4.0A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		2dd8 IGG HEAVY CHAIN
(Homo
sapiens)		5 / 12
VAL H 207
THR H 205
VAL H 211
GLY H 118
VAL H 152
1.06A19.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		2op9 REPLICASE
POLYPROTEIN 1AB
(PP1AB, ORF1AB)
3C-LIKE PROTEINASE
(3CL-PRO, 3CLP)
(SARSr-CoV)		6 / 12
VAL A  42
THR A  25
LEU A  89
PHE A  66
GLY A  23
VAL A  18
1.62A21.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		2q6g REPLICASE
POLYPROTEIN 1AB
(SARS-COV
BJ01)		5 / 12
VAL A  42
THR A  25
LEU A  89
GLY A  23
VAL A  18
1.21A20.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		3aw1 3C-LIKE PROTEINASE
(SARSr-CoV)		6 / 12
VAL A  42
THR A  25
LEU A  89
PHE A  66
GLY A  23
VAL A  18
1.56A20.73
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		3ea7 3C-LIKE PROTEINASE
(SARSr-CoV)		6 / 12
VAL A  42
THR A  25
LEU A  89
PHE A  66
GLY A  23
VAL A  18
1.58A20.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		3eaj 3C-LIKE PROTEINASE
(SARSr-CoV)		6 / 12
VAL A  42
THR A  25
LEU A  89
PHE A  66
GLY A  23
VAL A  18
1.53A20.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		3f9f 3C-LIKE PROTEINASE
(SARSr-CoV)		6 / 12
VAL B  42
THR B  25
LEU B  89
PHE B  66
GLY B  23
VAL B  18
1.57A21.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		3f9g 3C-LIKE PROTEINASE
(SARSr-CoV)		6 / 12
VAL A  42
THR A  25
LEU A  89
PHE A  66
GLY A  23
VAL A  18
1.61A21.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		3iwm 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL B  42
THR B  25
LEU B  89
PHE B  66
GLY B  23
1.19A20.49
None
010  F   6 (-3.1A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		3m3s 3C-LIKE PROTEINASE
(SARSr-CoV)		6 / 12
VAL B  42
THR B  25
LEU B  89
PHE B  66
GLY B  23
VAL B  18
1.67A20.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		3m3v 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL A  42
THR A  25
LEU A  89
GLY A  23
VAL A  18
1.23A20.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		3sna 3C-LIKE PROTEINASE
(SARSr-CoV)		6 / 12
VAL A  42
THR A  25
LEU A  89
PHE A  66
GLY A  23
VAL A  18
1.64A21.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		5b6o 3C-LIKE PROTEINASE
(SARSr-CoV)		6 / 12
VAL A  42
THR A  25
LEU A  89
PHE A  66
GLY A  23
VAL A  18
1.58A20.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		6 / 12
THR A  25
VAL A  35
LEU A  89
PHE A  66
GLY A  23
VAL A  18
1.65A17.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
VAL A  13
VAL A  35
LEU A  32
PHE A 159
VAL A  18
1.77A17.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		6 / 12
VAL A  42
THR A  25
LEU A  89
PHE A  66
GLY A  23
VAL A  18
1.57A17.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
VAL A 148
VAL A  35
LEU A  32
PHE A 159
VAL A  86
1.78A17.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
VAL A  13
SER A  10
VAL A  36
LEU A  30
PHE A 159
1.70A17.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
VAL A  13
SER A  10
VAL A  18
LEU A  30
PHE A 159
1.80A17.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		5x5c S PROTEIN
(MERS-CoV)		6 / 12
VAL C1124
SER C1125
LEU C 871
PHE C1001
GLY C1140
VAL C1128
1.50A16.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6ack SPIKE GLYCOPROTEIN
(SARSr-CoV)		6 / 12
VAL B 498
LEU B 499
PHE B 325
GLY B 512
PHE B 379
VAL B 369
1.63A17.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6crx SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		6 / 12
THR C 236
VAL C  80
PHE C  76
PHE C  22
ASN C 135
TYR C 252
1.77A17.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6lze VIRAL PROTEASE
(SARS-CoV-2)		6 / 12
VAL A  42
THR A  25
LEU A  89
PHE A  66
GLY A  23
VAL A  18
1.67A21.97
None
None
None
None
None
DMS  A 403 ( 4.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6lze VIRAL PROTEASE
(SARS-CoV-2)		6 / 12
THR A  25
VAL A  35
LEU A  89
PHE A  66
GLY A  23
VAL A  18
1.70A21.97
None
None
None
None
None
DMS  A 403 ( 4.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		6 / 12
THR A  25
VAL A  35
LEU A  89
PHE A  66
GLY A  23
VAL A  18
1.71A21.89
None
None
None
None
None
DMS  A 401 ( 4.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		6 / 12
VAL A  42
THR A  25
LEU A  89
PHE A  66
GLY A  23
VAL A  18
1.65A21.89
None
None
None
None
None
DMS  A 401 ( 4.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6m2n 3CL PROTEASE
(SARS-CoV-2)		6 / 12
VAL C  42
THR C  25
LEU C  89
PHE C  66
GLY C  23
VAL C  18
1.60A21.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6m2n 3CL PROTEASE
(SARS-CoV-2)		6 / 12
VAL B  42
THR B  25
LEU B  89
PHE B  66
GLY B  23
VAL B  18
1.61A21.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
VAL A  42
THR A  25
LEU A  87
GLY A  23
VAL A  18
1.57A21.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
THR A  25
VAL A  35
LEU A  89
GLY A  23
VAL A  18
1.55A21.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
VAL A  42
THR A  25
LEU A  89
GLY A  23
VAL A  18
1.44A21.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6m2n 3CL PROTEASE
(SARS-CoV-2)		6 / 12
VAL D  42
THR D  25
LEU D  89
PHE D  66
GLY D  23
VAL D  18
1.46A21.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6m2n 3CL PROTEASE
(SARS-CoV-2)		6 / 12
THR D  25
VAL D  35
LEU D  89
PHE D  66
GLY D  23
VAL D  18
1.55A21.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6m2n 3CL PROTEASE
(SARS-CoV-2)		6 / 12
THR B  25
VAL B  35
LEU B  89
PHE B  66
GLY B  23
VAL B  18
1.66A21.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6m2n 3CL PROTEASE
(SARS-CoV-2)		6 / 12
THR C  25
VAL C  35
LEU C  89
PHE C  66
GLY C  23
VAL C  18
1.66A21.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
VAL A  42
LEU A  89
PHE A  66
GLY A  23
VAL A  18
1.66A21.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6m2q 3CL PROTEASE
(SARS-CoV-2)		6 / 12
VAL A  42
THR A  25
LEU A  89
PHE A  66
GLY A  23
VAL A  18
1.58A21.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6m2q 3CL PROTEASE
(SARS-CoV-2)		6 / 12
THR A  25
VAL A  35
LEU A  89
PHE A  66
GLY A  23
VAL A  18
1.67A21.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6m71 NSP12
(SARS-CoV-2)		6 / 12
SER A 709
THR A 710
VAL A 472
GLY A 774
ASN A 703
VAL A 785
1.79A18.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6m71 NSP12
(SARS-CoV-2)		5 / 12
SER A 709
THR A 710
VAL A  31
GLY A 712
TYR A 129
1.57A18.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6m71 NSP12
(SARS-CoV-2)		5 / 12
SER A 709
THR A 710
GLY A 712
PHE A  48
TYR A 129
1.56A18.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6m71 NSP12
(SARS-CoV-2)		5 / 12
VAL A 764
SER A 754
PHE A 782
ASN A 695
VAL A 588
1.66A18.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6nb8 S230 ANTIGEN-BINDING
(FAB) FRAGMENT,
HEAVY CHAIN
(Homo
sapiens)		5 / 12
VAL H 221
THR H 219
VAL H 225
GLY H 132
VAL H 166
1.06A18.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6vww URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		6 / 12
THR A 145
VAL A 183
PHE A 135
GLY A 126
PHE A 123
TYR A 325
1.77A22.57
GOL  A 402 (-4.2A)
None
None
GOL  A 402 (-3.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		5 / 12
VAL H 182
THR H 183
VAL H 198
PHE L 118
VAL H 211
1.66A17.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6w41 CR3022 FAB HEAVY
CHAIN
SPIKE PROTEIN S1
(Homo
sapiens;
SARS-CoV-2)		5 / 12
SER H  96
THR H 100
VAL C 367
GLY C 381
PHE C 377
1.72A17.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		5 / 12
VAL C 367
LEU C 368
PHE C 377
GLY C 431
PHE C 515
1.80A17.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6w41 CR3022 FAB HEAVY
CHAIN
(Homo
sapiens)		5 / 12
VAL H 207
THR H 205
VAL H 211
GLY H 118
VAL H 152
1.01A17.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		5 / 12
SER C 514
THR C 430
VAL C 407
GLY C 381
VAL C 511
1.69A17.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		5 / 12
VAL L 163
LEU L 136
PHE L 139
ASN L 137
VAL H 181
1.65A16.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6w41 CR3022 FAB HEAVY
CHAIN
(Homo
sapiens)		5 / 12
VAL H 184
THR H 183
GLY H 162
ASN H 155
VAL H 211
1.68A17.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6w4b NSP9
(SARS-CoV-2)		6 / 12
VAL A 103
SER A 106
LEU A  89
PHE A  91
GLY B 101
VAL A 111
1.59A16.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
VAL A  42
THR A  25
LEU A  89
GLY A  23
VAL A  18
1.42A21.76
None
X77  A 401 (-4.2A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
THR A  25
VAL A  35
LEU A  89
PHE A  66
GLY A  23
1.64A21.76
X77  A 401 (-4.2A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
VAL A  42
THR A  25
LEU A  89
PHE A  66
GLY A  23
1.47A21.76
None
X77  A 401 (-4.2A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
VAL A  42
THR A  25
LEU A  87
GLY A  23
VAL A  18
1.54A21.76
None
X77  A 401 (-4.2A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
THR A  25
VAL A  35
LEU A  89
GLY A  23
VAL A  18
1.53A21.76
X77  A 401 (-4.2A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6w6y NSP3
(SARS-CoV-2)		5 / 12
VAL A  36
VAL A  24
LEU A  53
GLY A  97
VAL A 155
1.75A17.11
None
None
None
None
AMP  A 201 ( 4.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6w6y NSP3
(SARS-CoV-2)		5 / 12
VAL A  95
SER A  80
VAL A 121
LEU A 122
ASN A 117
1.67A17.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6w6y NSP3
(SARS-CoV-2)		5 / 12
VAL B  95
SER B  80
VAL B 121
LEU B 122
ASN B 117
1.69A17.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
SER B 170
THR B 168
PHE B 127
PHE B 241
VAL B 205
1.64A20.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6w9q 3C-LIKE PROTEINASE
PEPTIDE, NSP9 FUSION
(SARS-CoV-2)		5 / 12
VAL A 102
SER A 105
LEU A  88
PHE A  90
VAL A 110
1.59A18.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6wen NSP3
(SARS-CoV-2)		5 / 12
VAL A  95
SER A  80
VAL A 121
LEU A 122
ASN A 117
1.66A16.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6wey NSP3
(SARS-CoV-2)		5 / 12
VAL A 299
SER A 284
VAL A 325
LEU A 326
ASN A 321
1.65A17.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6wiq NSP7
(SARS-CoV-2)		5 / 12
VAL A  58
SER A  61
VAL A  12
LEU A  13
VAL A  66
1.54A11.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		6 / 12
THR A 145
VAL A 183
PHE A 135
GLY A 126
PHE A 123
TYR A 325
1.79A22.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		6 / 12
THR B 145
VAL B 183
PHE B 135
GLY B 126
PHE B 123
TYR B 325
1.79A22.37
ACT  B 408 (-4.0A)
None
None
ACT  B 408 (-4.2A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		6 / 12
VAL A  42
THR A  25
LEU A  89
PHE A  66
GLY A  23
VAL A  18
1.60A21.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		6 / 12
THR A  25
VAL A  35
LEU A  89
PHE A  66
GLY A  23
VAL A  18
1.67A21.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6wqd NSP7
(SARS-CoV-2)		5 / 12
VAL A  58
SER A  61
VAL A  12
LEU A  13
VAL A  66
1.53A11.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6wqd NSP7
(SARS-CoV-2)		5 / 12
VAL C  58
SER C  61
VAL C  12
LEU C  13
VAL C  66
1.46A11.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
VAL A  42
THR A  25
LEU A  89
PHE A  66
GLY A  23
1.45A21.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
VAL A  42
THR A  25
LEU A  87
GLY A  23
VAL A  18
1.56A21.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
VAL A  42
THR A  25
LEU A  89
GLY A  23
VAL A  18
1.39A21.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
THR A  25
VAL A  35
LEU A  89
PHE A  66
GLY A  23
1.63A21.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
THR A  25
VAL A  35
LEU A  89
GLY A  23
VAL A  18
1.49A21.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6wrh PEPTIDASE C16
(SARS-CoV-2)		5 / 12
THR A 210
VAL A 184
LEU A 185
GLY A 209
VAL A 205
1.64A20.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6y2g REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		6 / 12
VAL B  42
THR B  25
LEU B  89
PHE B  66
GLY B  23
VAL B  18
1.54A21.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL A  42
THR A  25
LEU A  89
PHE A  66
GLY A  23
1.42A17.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL A  42
THR A  25
LEU A  89
GLY A  23
VAL A  18
1.40A17.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL A  13
SER A  10
VAL A  36
LEU A  30
PHE A 159
1.70A17.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
THR A  25
VAL A  35
LEU A  89
PHE A  66
GLY A  23
1.62A17.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL A  42
THR A  25
LEU A  87
GLY A  23
VAL A  18
1.53A17.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL A  13
VAL A  35
LEU A  32
PHE A 159
VAL A  18
1.78A17.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL A 148
VAL A  35
LEU A  32
PHE A 159
VAL A  86
1.78A17.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
THR A  25
VAL A  35
LEU A  89
GLY A  23
VAL A  18
1.51A17.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL A  13
SER A  10
VAL A  18
LEU A  30
PHE A 159
1.80A17.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
VAL C  58
SER C  61
VAL C  12
LEU C  13
VAL C  66
1.52A11.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
VAL A  58
SER A  61
VAL A  12
LEU A  13
VAL A  66
1.53A11.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL A 512
LEU A 513
PHE A 338
GLY A 526
VAL A 382
1.40A18.54
None
None
None
None
DMS  A 905 (-4.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6yla HEAVY CHAIN
(Homo
sapiens)		5 / 12
VAL H 211
THR H 209
VAL H 215
GLY H 122
VAL H 156
1.17A17.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6yla LIGHT CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
THR E 430
LEU E 390
PHE E 392
GLY E 431
TYR L  97
1.43A18.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6yla LIGHT CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
THR A 430
LEU A 390
PHE A 392
GLY A 431
TYR C  97
1.36A18.54
None
DMS  A 905 (-4.9A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		5 / 12
VAL H 186
THR H 187
VAL H 202
PHE L 124
VAL H 215
1.64A17.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6yla HEAVY CHAIN
(Homo
sapiens)		5 / 12
VAL H 188
THR H 187
GLY H 166
ASN H 159
VAL H 215
1.66A17.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6yla HEAVY CHAIN
(Homo
sapiens)		5 / 12
VAL B 211
THR B 209
VAL B 215
GLY B 122
VAL B 156
1.15A17.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		5 / 12
VAL B 186
THR B 187
VAL B 202
PHE C 124
VAL B 215
1.62A17.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		5 / 12
VAL L 169
LEU L 142
PHE L 145
ASN L 143
VAL H 185
1.65A19.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL E 512
LEU E 513
PHE E 338
GLY E 526
VAL E 382
1.42A18.54
None
None
None
None
DMS  L1601 (-4.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6ym0 LIGHT CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
THR E 430
LEU E 390
PHE E 392
GLY E 431
TYR L  97
1.36A18.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6ym0 HEAVY CHAIN
(Homo
sapiens)		5 / 12
VAL H 211
THR H 209
VAL H 215
GLY H 122
VAL H 156
1.12A17.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6ym0 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL E 512
LEU E 513
PHE E 338
GLY E 526
VAL E 382
1.41A18.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6ym0 HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		5 / 12
VAL H 186
THR H 187
VAL H 202
PHE L 124
VAL H 215
1.63A17.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL A  42
THR A  25
LEU A  87
GLY A  23
VAL A  18
1.66A22.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
THR A  25
VAL A  35
LEU A  89
GLY A  23
VAL A  18
1.66A22.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL A  42
THR A  25
LEU A  89
GLY A  23
VAL A  18
1.58A22.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL A  13
SER A  10
VAL A  36
LEU A  30
PHE A 159
1.65A22.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6yor IGG H CHAIN
(Homo
sapiens)		5 / 12
VAL H 188
THR H 187
GLY H 166
ASN H 159
VAL H 215
1.66A17.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		5 / 12
VAL H 186
THR H 187
VAL H 202
PHE L 124
VAL H 215
1.64A17.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		5 / 12
VAL B 186
THR B 187
VAL B 202
PHE C 124
VAL B 215
1.65A17.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		5 / 12
VAL C 169
LEU C 142
PHE C 145
ASN C 143
VAL B 185
1.65A19.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		5 / 12
VAL L 169
LEU L 142
PHE L 145
ASN L 143
VAL H 185
1.64A19.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL E 512
LEU E 513
PHE E 338
GLY E 526
VAL E 382
1.42A17.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6yor IGG H CHAIN
(Homo
sapiens)		5 / 12
VAL B 211
THR B 209
VAL B 215
GLY B 122
VAL B 156
1.17A17.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6yor IGG L CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
THR A 430
LEU A 390
PHE A 392
GLY A 431
TYR C  97
1.44A17.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL A 512
LEU A 513
PHE A 338
GLY A 526
VAL A 382
1.41A17.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6yor IGG H CHAIN
(Homo
sapiens)		5 / 12
VAL H 211
THR H 209
VAL H 215
GLY H 122
VAL H 156
1.17A17.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6yor IGG L CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
THR E 430
LEU E 390
PHE E 392
GLY E 431
TYR L  97
1.43A17.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
THR A  25
VAL A  35
LEU A  89
GLY A  23
VAL A  18
1.53A22.25
PK8  A 401 ( 4.4A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL A  42
THR A  25
LEU A  87
GLY A  23
VAL A  18
1.53A22.25
None
PK8  A 401 ( 4.4A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL A  42
THR A  25
LEU A  89
PHE A  66
GLY A  23
1.43A22.25
None
PK8  A 401 ( 4.4A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
THR A  25
VAL A  35
LEU A  89
PHE A  66
GLY A  23
1.63A22.25
PK8  A 401 ( 4.4A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL A  42
THR A  25
LEU A  89
GLY A  23
VAL A  18
1.42A22.25
None
PK8  A 401 ( 4.4A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL C  95
SER C  80
VAL C 121
LEU C 122
ASN C 117
1.64A17.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL E  95
SER E  80
VAL E 121
LEU E 122
ASN E 117
1.65A17.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL B  95
SER B  80
VAL B 121
LEU B 122
ASN B 117
1.63A17.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL D  95
SER D  80
VAL D 121
LEU D 122
ASN D 117
1.64A17.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL A  95
SER A  80
VAL A 121
LEU A 122
ASN A 117
1.65A17.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL B  95
SER B  80
VAL B 121
LEU B 122
ASN B 117
1.65A17.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL D  95
SER D  80
VAL D 121
LEU D 122
ASN D 117
1.65A17.32
None
EDO  D 203 (-3.6A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL B  95
SER B  80
VAL B 121
LEU B 122
ASN B 117
1.64A17.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		7bqy MAIN PROTEASE
(SARS-CoV-2)		6 / 12
VAL A  42
THR A  25
LEU A  89
PHE A  66
GLY A  23
VAL A  18
1.57A21.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		7bqy MAIN PROTEASE
(SARS-CoV-2)		6 / 12
THR A  25
VAL A  35
LEU A  89
PHE A  66
GLY A  23
VAL A  18
1.64A21.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		7btf NSP12
(SARS-CoV-2)		5 / 12
VAL A 588
THR A 591
VAL A 764
PHE A 812
GLY A 597
1.64A18.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		7btf NSP12
(SARS-CoV-2)		5 / 12
SER A 709
THR A 710
GLY A 712
PHE A  48
TYR A 129
1.50A18.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		7btf NSP7
NSP8
(SARS-CoV-2)		5 / 12
SER C  61
VAL C  12
LEU D  91
PHE D  92
GLY C  64
1.52A11.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		7btf NSP12
(SARS-CoV-2)		5 / 12
SER A 709
THR A 710
VAL A  31
GLY A 712
TYR A 129
1.61A18.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		6 / 12
VAL A  42
THR A  25
LEU A  89
PHE A  66
GLY A  23
VAL A  18
1.64A21.76
None
None
None
None
None
DMS  A 403 ( 4.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		6 / 12
THR A  25
VAL A  35
LEU A  89
PHE A  66
GLY A  23
VAL A  18
1.71A21.76
None
None
None
None
None
DMS  A 403 ( 4.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
SER A 709
THR A 710
VAL A  31
GLY A 712
TYR A 129
1.48A18.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
VAL A 588
THR A 591
VAL A 764
PHE A 812
GLY A 597
1.65A18.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
SER A 709
THR A 710
GLY A 712
PHE A  48
TYR A 129
1.32A18.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		7bv2 NSP12
NSP8
(SARS-CoV-2)		5 / 12
VAL A 335
SER A 363
LEU B  95
PHE B  92
VAL A 342
1.50A18.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
VAL A 588
THR A 591
VAL A 764
PHE A 812
GLY A 597
1.63A18.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
SER A 709
THR A 710
GLY A 712
PHE A  48
TYR A 129
1.54A18.61
None