Ligand ID: H8D


Drugbank ID:
DB00353
(Methylergometrine)


Indication:
For the prevention and control of excessive bleeding following vaginal childbirth

Get human targets for H8D in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'H8D'

Click here for results that match SARS-Cov-2 / COVID-19 structures only
Click here for results that match SARS-related structures only


1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		1x7q HLA, A-11
(Homo
sapiens)		5 / 11
ASP A  29
VAL A  28
LEU A 172
ALA A  49
TYR A 209
1.58A17.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		2dd8 SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 11
VAL S 420
LEU S 421
ALA S 350
PHE S 501
VAL S 369
1.58A18.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		2fe8 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 11
THR B  91
LEU B 133
ALA B 146
VAL B 117
TYR B 113
1.59A20.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 11
VAL F 275
SER F 273
THR F 274
ALA F 325
VAL D  35
1.31A20.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		3bgf F26G19 FAB
SPIKE PROTEIN S1
(Mus
musculus;
SARSr-CoV)		5 / 11
ASP S 393
VAL S 394
ALA S 422
GLN H  99
TYR S 481
1.58A18.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		3e9s NSP3
(SARSr-CoV)		5 / 11
THR A  91
LEU A 133
ALA A 146
VAL A 117
TYR A 113
1.58A19.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		3eaj 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
VAL B 204
VAL B 261
LEU B 250
ALA B 291
VAL B 212
1.60A19.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		3i6g HLA, A-2
(Homo
sapiens)		5 / 11
ASP A  29
VAL A  28
LEU A 172
ALA A  49
TYR A 209
1.47A20.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		3i6l HLA, A-24
(Homo
sapiens)		5 / 11
ASP D  29
VAL D  28
LEU D 172
ALA D  49
TYR D 209
1.56A19.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		3sci SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 11
VAL F 420
THR F 363
VAL F 382
ALA F 422
PHE F 329
1.59A17.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		4m0w REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		5 / 11
THR A  91
LEU A 133
ALA A 146
VAL A 117
TYR A 113
1.59A19.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		4ovz PAPAIN-LIKE
PROTEINASE
(SARS-COV
Urbani)		5 / 11
THR B  91
LEU B 133
ALA B 146
VAL B 117
TYR B 113
1.55A20.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		5c8u GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		5 / 11
VAL D 317
SER D 319
VAL D 398
LEU D 383
ALA D 344
1.62A21.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		5wrg SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 11
ASP C 385
VAL C 498
SER C 386
LEU C 412
ALA C 422
1.52A17.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		5x29 ENVELOPE SMALL
MEMBRANE PROTEIN
(SARSr-CoV)		5 / 11
VAL A  47
VAL A  24
LEU A  27
ALA A  40
VAL E  58
1.54A12.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 11
VAL B 420
LEU B 421
ALA B 350
PHE B 501
VAL B 369
1.43A17.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		5x5f S PROTEIN
(MERS-CoV)		5 / 11
VAL B 263
THR B 259
VAL B 170
LEU B 171
PHE B 112
1.54A15.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		5y3e REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		5 / 11
THR A  91
LEU A 133
ALA A 146
VAL A 117
TYR A 113
1.52A19.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6ack SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 11
VAL C 601
SER C 577
LEU C 597
ALA C 609
GLN C 301
1.43A17.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6crw SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 11
VAL B 420
THR B 363
ALA B 422
PHE B 329
TYR B 352
1.34A17.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 11
ASP A  29
VAL A  28
LEU A 172
ALA A  49
TYR A 209
1.57A19.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6m17 RECEPTOR BINDING
DOMAIN
(SARS-CoV-2)		5 / 11
ASP E 398
VAL E 512
SER E 399
LEU E 425
ALA E 435
1.51A19.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6m1d SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 11
VAL C 320
SER C 323
VAL C 233
LEU C 234
PHE C 403
1.41A20.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6m71 NSP12
(SARS-CoV-2)		5 / 11
THR A 687
VAL A 700
ALA A 688
PHE A 480
VAL A 637
1.57A18.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6nur NSP12
(SARSr-CoV)		5 / 11
THR A 687
VAL A 700
ALA A 688
PHE A 480
VAL A 637
1.59A17.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		5 / 11
VAL C 433
THR C 376
VAL C 395
ALA C 435
PHE C 342
1.72A17.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6w6y NSP3
(SARS-CoV-2)		5 / 11
VAL A  95
SER A  80
VAL A 121
LEU A 122
ALA A 112
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6w75 NSP16
(SARS-CoV-2)		5 / 11
VAL C7087
SER C7089
THR C6918
ALA C6919
VAL A6916
1.68A19.46
None
None
FMT  C7113 ( 4.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 11
THR B 210
VAL B 184
LEU B 185
VAL B 242
TYR B 213
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 11
THR C 210
VAL C 184
LEU C 185
VAL C 242
TYR C 213
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 11
THR A 210
VAL A 184
LEU A 185
VAL A 242
TYR A 213
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6wcf NSP3
(SARS-CoV-2)		5 / 11
VAL A 142
LEU A 109
ALA A  39
PHE A 116
VAL A 151
1.75A
None
None
MES  A 201 ( 4.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6wey NSP3
(SARS-CoV-2)		5 / 11
VAL A 299
SER A 284
VAL A 325
LEU A 326
ALA A 316
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6wiq NSP7
(SARS-CoV-2)		5 / 11
VAL A  58
SER A  61
VAL A  12
LEU A  13
VAL A  66
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 11
VAL C 158
THR C  54
ALA C 156
GLN C  83
TYR C  87
1.79A
None
MES  D 201 (-4.6A)
MES  D 201 ( 4.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6wkq NSP10
(SARS-CoV-2)		5 / 11
ASP D4275
LEU D4365
ALA D4285
PHE B4272
VAL B4274
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6wkq NSP16
(SARS-CoV-2)		5 / 11
VAL C7087
SER C7089
THR C6918
ALA C6919
VAL A6916
1.65A
None
None
FMT  C7108 ( 4.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 11
VAL B 142
LEU B 109
ALA B  39
PHE B 116
VAL B 151
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6wqd NSP7
(SARS-CoV-2)		5 / 11
VAL A  58
SER A  61
VAL A  12
LEU A  13
VAL A  66
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6wqd NSP7
(SARS-CoV-2)		5 / 11
VAL C  58
SER C  61
VAL C  12
LEU C  13
VAL C  66
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6wrh PEPTIDASE C16
(SARS-CoV-2)		5 / 11
THR A 210
VAL A 184
LEU A 185
VAL A 242
TYR A 213
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 11
VAL C  58
SER C  61
VAL C  12
LEU C  13
VAL C  66
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 11
VAL A  58
SER A  61
VAL A  12
LEU A  13
VAL A  66
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 11
VAL A 433
THR A 376
VAL A 395
ALA A 435
PHE A 342
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
VAL C  95
SER C  80
VAL C 121
LEU C 122
ALA C 112
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
VAL D  95
SER D  80
VAL D 121
LEU D 122
ALA D 112
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
VAL E  95
SER E  80
VAL E 121
LEU E 122
ALA E 112
1.80A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
VAL B  95
SER B  80
VAL B 121
LEU B 122
ALA B 112
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
VAL A  95
SER A  80
VAL A 121
LEU A 122
ALA A 112
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
VAL B  95
SER B  80
VAL B 121
LEU B 122
ALA B 112
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 11
VAL B  95
SER B  80
VAL B 121
LEU B 122
ALA B 112
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		7btf NSP12
(SARS-CoV-2)		5 / 11
VAL A 330
VAL A 535
ALA A 383
VAL A 373
TYR A 374
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		7btf NSP12
NSP8
(SARS-CoV-2)		5 / 11
VAL B 160
SER B 164
VAL B 130
PHE A 407
VAL A 405
1.80A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		7btf NSP12
NSP7
NSP8
(SARS-CoV-2)		5 / 11
ASP B 163
VAL B 159
LEU B 184
ALA C  30
PHE A 407
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		7btf NSP12
(SARS-CoV-2)		5 / 11
THR A 687
VAL A 700
ALA A 688
PHE A 480
VAL A 637
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		7bv1 NSP12
(SARS-CoV-2)		5 / 11
VAL A 330
VAL A 535
ALA A 383
VAL A 373
TYR A 374
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		7bv1 NSP12
(SARS-CoV-2)		5 / 11
VAL A 330
VAL A 535
ALA A 382
VAL A 373
TYR A 374
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		7bv2 NSP12
NSP7
NSP8
(SARS-CoV-2)		5 / 11
ASP B 163
SER C  26
VAL B 159
LEU B 184
PHE A 407
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		7bv2 NSP12
(SARS-CoV-2)		5 / 11
VAL A 560
SER A 564
THR A 565
VAL A 667
ALA A 685
1.73A
 U  T  10 ( 4.6A)
None
None
None
A  T  11 ( 4.7A)