Results

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	RMSD	Seq. Identity (%)	HETATM
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_1 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	1q2w	3C-LIKE PROTEASE (SARSr-CoV)	4 / 8	ARG A 105 VAL A 13 ARG A 298 GLN A 299	1.54A	12.85	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	1wnc	E2 GLYCOPROTEIN (SARSr-CoV)	4 / 8	GLN F 939 THR F 943 VAL F 945 SER F1156	1.38A	7.18	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_1 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	1x7q	HLA, A-11 (Homo sapiens)	4 / 8	ARG A 44 VAL A 76 ARG A 114 GLN A 156	1.40A	12.99	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6C06_D_FI8D1404_1 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	1x7q	BETA-2-MICROGLOBULIN HLA, A-11 (Homo sapiens)	3 / 3	ARG B 45 LYS B 48 ARG A 48	1.80A	6.09	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_1 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	1z1j	3C-LIKE PROTEINASE (SARSr-CoV)	4 / 8	ASP B1176 ARG B1105 VAL B1013 ARG B1298	1.60A	13.68	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	1zv8	E2 GLYCOPROTEIN (SARSr-CoV)	4 / 8	VAL L 22 LYS L 24 GLU K 18 SER K 14	1.45A	3.13	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_1 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	2a5k	3C-LIKE PEPTIDASE (SARSr-CoV)	4 / 8	ARG B 105 VAL B 13 ARG B 298 GLN B 299	1.60A	13.27	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BZO_C_FI8C1201_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA)	2ahm	REPLICASE POLYPROTEIN 1AB, HEAVY CHAIN REPLICASE POLYPROTEIN 1AB, LIGHT CHAIN (SARSr-CoV)	5 / 12	MET A 67 THR E 89 VAL E 88 LYS E 84 VAL A 17	1.67A	6.46	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	2ahm	REPLICASE POLYPROTEIN 1AB, HEAVY CHAIN REPLICASE POLYPROTEIN 1AB, LIGHT CHAIN (SARSr-CoV)	4 / 8	GLN G 93 THR G 89 VAL G 88 SER C 20	1.45A	10.72	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BZO_C_FI8C1201_2 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA RNA POLYMERASE SIGMA FACTOR SIGA)	2ahm	REPLICASE POLYPROTEIN 1AB, LIGHT CHAIN (SARSr-CoV)	4 / 4	LEU A 76 ASP A 72 GLN A 68 VAL D 11	1.08A	10.36	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_1 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	2d2d	3C-LIKE PROTEINASE (SARSr-CoV)	4 / 8	ASP B 187 ARG B 40 VAL B 171 GLN B 110	1.51A	13.34	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BZO_C_FI8C1201_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA)	2fe8	REPLICASE POLYPROTEIN 1AB (SARSr-CoV)	5 / 12	MET C 209 GLN B 270 VAL C 188 LYS C 196 GLU B 162	1.40A	13.92	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6C06_D_FI8D1404_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	2fe8	REPLICASE POLYPROTEIN 1AB (SARSr-CoV)	4 / 8	THR B 275 THR B 278 LYS B 280 SER B 104	1.37A	13.92	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	2fe8	REPLICASE POLYPROTEIN 1AB (SARSr-CoV)	4 / 8	ILE A 315 VAL A 243 GLU A 308 SER A 310	1.36A	13.85	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6C06_D_FI8D1404_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	2ga6	ORF1A POLYPROTEIN (SARSr-CoV)	4 / 8	THR N 47 THR I 47 GLU N 66 SER N 67	1.42A	8.86	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BZO_C_FI8C1201_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA)	2ghw	ANTI-SCFV ANTIBODY, 80R (Homo sapiens)	5 / 12	THR B 137 GLN B 138 THR B 234 VAL B 217 VAL B 236	1.55A	11.60	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BZO_C_FI8C1201_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA)	2h85	PUTATIVE ORF1AB POLYPROTEIN (SARSr-CoV)	5 / 12	THR A 195 GLN A 159 THR A 166 VAL A 165 VAL A 162	1.63A	17.43	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	2jze	REPLICASE POLYPROTEIN 1AB (SARSr-CoV)	4 / 8	MET A 557 ILE A 560 VAL A 611 SER A 634	1.37A	7.39	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BZO_C_FI8C1201_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA)	2jze	REPLICASE POLYPROTEIN 1AB (SARSr-CoV)	5 / 12	MET A 551 THR A 605 VAL A 604 VAL A 633 VAL A 578	1.68A	7.32	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BZO_C_FI8C1201_2 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA RNA POLYMERASE SIGMA FACTOR SIGA)	2ozk	URIDYLATE-SPECIFIC ENDORIBONUCLEASE (SARSr-CoV)	4 / 4	LEU D 297 ASP D 301 GLN D 196 VAL B 317	1.62A	21.31	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BZO_C_FI8C1201_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA)	2ozk	URIDYLATE-SPECIFIC ENDORIBONUCLEASE (SARSr-CoV)	5 / 12	THR C 195 GLN C 159 THR C 166 VAL C 165 VAL C 162	1.60A	16.88	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6C06_D_FI8D1404_1 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	2ozk	URIDYLATE-SPECIFIC ENDORIBONUCLEASE (SARSr-CoV)	3 / 3	ARG D 257 LYS D 256 ARG D 206	1.63A	14.25	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	2ozk	URIDYLATE-SPECIFIC ENDORIBONUCLEASE (SARSr-CoV)	4 / 8	GLN A 208 THR A 211 LYS A 204 GLU A 215	1.34A	15.22	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_1 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	2ozk	URIDYLATE-SPECIFIC ENDORIBONUCLEASE (SARSr-CoV)	4 / 8	ARG B 257 VAL A 165 ARG B 206 GLN B 159	1.53A	14.25	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_1 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	2qc2	3C-LIKE PROTEINASE (-)	4 / 8	ASP B 176 ARG B 105 VAL B 13 ARG B 298	1.41A	13.39	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	2rhb	URIDYLATE-SPECIFIC ENDORIBONUCLEASE (SARSr-CoV)	4 / 8	ILE D 42 VAL D 53 GLU D 56 SER D 1	1.39A	14.81	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BZO_C_FI8C1201_2 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA RNA POLYMERASE SIGMA FACTOR SIGA)	2rhb	URIDYLATE-SPECIFIC ENDORIBONUCLEASE (SARSr-CoV)	4 / 4	LEU C 297 ASP C 301 GLN C 196 VAL A 35	1.71A	21.14	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6C06_D_FI8D1404_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	2rhb	URIDYLATE-SPECIFIC ENDORIBONUCLEASE (SARSr-CoV)	4 / 8	ILE B 280 THR B 281 GLU C 170 SER C 171	1.20A	16.67	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BZO_C_FI8C1201_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA)	2rhb	URIDYLATE-SPECIFIC ENDORIBONUCLEASE (SARSr-CoV)	5 / 12	THR E 195 GLN E 159 THR E 166 VAL E 165 VAL E 162	1.65A	16.67	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_1 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	2vj1	MAIN PROTEINASE (SARSr-CoV)	4 / 8	ASP B 187 ARG B 40 VAL B 171 GLN B 110	1.60A	12.06	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	2wct	NSP3 (SARSr-CoV)	4 / 8	MET D 557 ILE D 556 THR B 398 VAL B 397	1.35A	12.72	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6C06_D_FI8D1404_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	3aw1	3C-LIKE PROTEINASE (SARSr-CoV)	4 / 8	ILE A 188 THR A 190 GLN A 192 GLU A 166	1.42A	13.07	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_1 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	3bgf	F26G19 FAB (Mus musculus)	4 / 8	ASP L 165 LYS L 39 GLU L 38 VAL H 89	1.45A	9.74	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_1 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	3ea7	3C-LIKE PROTEINASE (SARSr-CoV)	4 / 8	ASP B 176 ARG B 105 VAL B 13 ARG B 298	1.46A	12.36	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_1 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	3eaj	3C-LIKE PROTEINASE (SARSr-CoV)	4 / 8	ASP A 176 ARG A 105 VAL A 13 ARG A 298	1.50A	12.36	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6C06_D_FI8D1404_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	3ebn	REPLICASE POLYPROTEIN 1AB (SARSr-CoV)	4 / 8	ILE A 200 THR A 199 GLU B 288 SER B 284	1.33A	7.96	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_1 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	3f9e	3C-LIKE PROTEINASE (SARSr-CoV)	4 / 8	ASP A 187 ARG A 40 VAL A 171 GLN A 110	1.60A	13.63	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_1 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	3f9g	3C-LIKE PROTEINASE (SARSr-CoV)	4 / 8	ASP A 263 ARG A 222 GLU A 270 VAL A 233	1.58A	13.23	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_1 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	3f9h	3C-LIKE PROTEINASE (SARSr-CoV)	4 / 8	ARG B 105 VAL B 13 ARG B 298 GLN B 299	1.59A	13.48	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_1 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	3m3t	3C-LIKE PROTEINASE (SARSr-CoV)	4 / 8	ASP A 187 ARG A 40 VAL A 171 GLN A 110	1.59A	13.39	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_1 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	3m3v	3C-LIKE PROTEINASE (SARSr-CoV)	4 / 8	ASP B 187 ARG B 40 VAL B 171 GLN B 110	1.58A	12.34	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	3mj5	REPLICASE POLYPROTEIN 1A (SARSr-CoV)	4 / 8	ILE B 315 VAL B 243 GLU B 308 SER B 310	1.44A	13.84	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6C06_D_FI8D1404_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	3mj5	REPLICASE POLYPROTEIN 1A (SARSr-CoV)	4 / 8	THR B 275 THR B 278 LYS B 280 SER B 104	1.39A	13.91	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_1 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	3sna	3C-LIKE PROTEINASE (SARSr-CoV)	4 / 8	ASP A 187 ARG A 40 VAL A 171 GLN A 110	1.43A	13.19	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6C06_D_FI8D1404_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	3vb3	3C-LIKE PROTEINASE (SARSr-CoV)	4 / 8	ILE B 281 THR B 280 GLU A 288 SER A 284	1.35A	13.33	None None EDO A 402 (-3.7A) None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_1 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	3vb4	3C-LIKE PROTEINASE (SARSr-CoV)	4 / 8	ARG A 88 GLU A 55 ARG A 188 GLN A 192	1.36A	13.43	EDO A 402 (-4.1A) None None None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6C06_D_FI8D1404_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	4m0w	REPLICASE POLYPROTEIN 1A UBIQUITIN (Bos taurus; SARSr-CoV)	4 / 8	ILE B 36 GLN B 40 LYS A 158 GLU A 168	1.23A	5.01	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	4tww	3C-LIKE PROTEINASE (SARSr-CoV)	4 / 8	ILE A 281 THR A 304 VAL A 303 SER A 1	1.39A	13.13	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6C06_D_FI8D1404_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	5b6o	3C-LIKE PROTEINASE (SARSr-CoV)	4 / 8	ILE A 213 THR A 257 GLN A 256 THR A 304	1.45A	13.50	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_1 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	5c5o	3C-LIKE PROTEINASE (SARSr-CoV)	4 / 8	ASP A 176 ARG A 105 VAL A 13 ARG A 298	1.60A	13.43	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_1 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	5c8s	GUANINE-N7 METHYLTRANSFERASE (SARSr-CoV)	4 / 8	ASP B 390 ARG B 391 ARG B 400 VAL B 287	1.39A	16.78	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_1 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	5c8t	GUANINE-N7 METHYLTRANSFERASE (SARSr-CoV)	4 / 8	ASP B 390 ARG B 391 ARG B 400 VAL B 287	1.51A	16.84	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	5c8u	NSP10 (SARSr-CoV)	4 / 8	ILE C 99 GLN C 98 THR C 56 VAL C 57	1.29A	8.58	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6C06_D_FI8D1404_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	5e6j	REPLICASE POLYPROTEIN 1AB UBIQUITIN (SARSr-CoV; synthetic construct)	4 / 8	ILE E 36 GLN E 40 LYS D 158 GLU D 168	1.12A	4.91	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BZO_C_FI8C1201_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA)	5e6j	POLYUBIQUITIN-B REPLICASE POLYPROTEIN 1AB (SARSr-CoV; synthetic construct)	5 / 12	ILE C 13 THR C 12 THR D 10 VAL D 58 GLU C 64	1.46A	5.07	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	5e6j	REPLICASE POLYPROTEIN 1AB (SARSr-CoV)	4 / 8	MET A 170 THR A 302 VAL A 301 GLU A 264	1.43A	13.63	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	5nfy	POLYPROTEIN 1AB (SARS-COV Frankfurt 1)	4 / 8	ILE P 99 GLN P 98 THR P 56 VAL P 57	1.44A	8.32	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6C06_D_FI8D1404_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	5nfy	POLYPROTEIN 1AB (SARS-COV Frankfurt 1)	4 / 8	ILE M 38 THR M 39 THR A 5 SER A 28	1.46A	7.78	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	5nfy	POLYPROTEIN 1AB (SARS-COV Frankfurt 1)	5 / 8	MET B 58 THR B 5 VAL N 7 LYS B 1 GLU N 6	1.60A	17.63	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	5tl7	REPLICASE POLYPROTEIN 1AB (SARSr-CoV)	4 / 8	ILE B 315 VAL B 243 GLU B 308 SER B 310	1.43A	14.01	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	5wrg	SPIKE GLYCOPROTEIN (SARSr-CoV)	4 / 8	ILE A 704 VAL A1015 GLU A1013 SER A1019	0.93A	22.89	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6C06_D_FI8D1404_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	5x4s	SPIKE GLYCOPROTEIN (SARSr-CoV)	4 / 8	ILE A 72 THR A 71 THR A 92 SER A 95	1.32A	11.93	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BZO_C_FI8C1201_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA)	5x58	SPIKE GLYCOPROTEIN (SARS-COV BJ01)	5 / 12	ILE B 72 THR B 71 THR B 92 SER B 95 GLU B 174	1.42A	22.65	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6C06_D_FI8D1404_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	5x5b	SPIKE GLYCOPROTEIN (SARS-COV BJ01)	4 / 8	ILE A 72 THR A 71 THR A 92 SER A 95	1.27A	22.65	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	5x5b	SPIKE GLYCOPROTEIN (SARS-COV BJ01)	4 / 8	GLN B 32 THR B 67 VAL B 254 SER B 64	1.42A	22.84	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_1 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	5x5b	SPIKE GLYCOPROTEIN (SARS-COV BJ01)	4 / 8	ASP C 85 ARG B 449 GLU B 452 ARG B 441	1.48A	23.32	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6C06_D_FI8D1404_1 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	5x5b	SPIKE GLYCOPROTEIN (SARS-COV BJ01)	3 / 3	ARG C 183 LYS C 198 ARG B 544	1.48A	23.31	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_1 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	5x5f	S PROTEIN (MERS-CoV)	4 / 8	ASP C1064 VAL A 458 ARG A 401 GLN B 261	1.48A	21.90	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BZO_C_FI8C1201_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA)	5x5f	S PROTEIN (MERS-CoV)	5 / 12	THR A1043 GLN C 636 VAL C 639 VAL C 631 VAL A 929	1.54A	21.65	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	5x5f	S PROTEIN (MERS-CoV)	4 / 8	GLN B 628 THR C 63 VAL B 631 SER B 643	1.07A	21.84	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BZO_C_FI8C1201_2 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA RNA POLYMERASE SIGMA FACTOR SIGA)	5x5f	S PROTEIN (MERS-CoV)	4 / 4	LEU C1061 ASP C1064 GLN C1063 VAL A 555	1.52A	16.88	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BZO_C_FI8C1201_2 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA RNA POLYMERASE SIGMA FACTOR SIGA)	5xlr	SPIKE GLYCOPROTEIN (SARSr-CoV)	4 / 4	LEU B 930 ASP B 932 GLN B 931 VAL B 860	1.75A	18.04	LEU B 930 ( 0.6A) ASP B 932 ( 0.6A) GLN B 931 ( 0.6A) VAL B 860 ( 0.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	5y3e	REPLICASE POLYPROTEIN 1A (SARSr-CoV)	4 / 8	ILE A 315 VAL A 243 GLU A 308 SER A 310	1.46A	13.63	None NA A 406 ( 4.1A) None None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BZO_C_FI8C1201_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA)	5zvm	SPIKE GLYCOPROTEIN (SARSr-CoV)	5 / 12	THR A 894 GLN A 895 THR B 894 VAL B 897 VAL B 893	1.63A	6.38	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BZO_C_FI8C1201_2 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA RNA POLYMERASE SIGMA FACTOR SIGA)	5zvm	PAN-COV INHIBITORY PEPTIDE EK1 SPIKE GLYCOPROTEIN (SARSr-CoV; synthetic construct)	4 / 4	LEU b 39 ASP b 38 GLN C 904 VAL B 893	1.38A	6.26	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	5zvm	PAN-COV INHIBITORY PEPTIDE EK1 SPIKE GLYCOPROTEIN (SARSr-CoV; synthetic construct)	4 / 8	ILE b 37 GLN B 902 VAL B 897 GLU B 900	1.40A	3.75	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BZO_C_FI8C1201_2 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA RNA POLYMERASE SIGMA FACTOR SIGA)	6acg	SPIKE GLYCOPROTEIN (SARSr-CoV)	4 / 4	LEU C 930 ASP C 932 GLN C 931 VAL C 860	1.72A	18.04	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_1 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6acj	ACE2 (Homo sapiens)	4 / 8	ASP D 201 ARG D 219 GLU D 398 GLN D 524	1.55A	19.20	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BZO_C_FI8C1201_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA)	6ack	ACE2 (Homo sapiens)	5 / 12	ILE D 446 THR D 445 GLN D 442 VAL D 293 GLU D 402	1.69A	18.77	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6ack	ACE2 (Homo sapiens)	4 / 8	ILE D 484 THR D 229 VAL D 581 GLU D 232	1.41A	18.78	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6C06_D_FI8D1404_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6ack	SPIKE GLYCOPROTEIN (SARSr-CoV)	4 / 8	ILE B1086 THR B1087 GLN B1088 THR B 894	1.22A	22.56	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BZO_C_FI8C1201_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA)	6ack	SPIKE GLYCOPROTEIN (SARSr-CoV)	5 / 12	THR B 146 GLN B 147 VAL B 123 SER B 95 GLU B 174	1.37A	22.56	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6ack	SPIKE GLYCOPROTEIN (SARSr-CoV)	4 / 8	ILE A 787 GLN A 917 GLU A 918 SER A 919	1.12A	22.89	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6C06_D_FI8D1404_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6crv	SPIKE GLYCOPROTEIN,FIBRITI N (SARSr-CoV)	4 / 8	ILE A 72 THR A 71 THR A 92 SER A 95	1.18A	22.74	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_1 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6crv	SPIKE GLYCOPROTEIN,FIBRITI N (SARSr-CoV)	4 / 8	ASP C 44 VAL C 186 ARG C 620 GLN C 280	1.46A	23.18	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6crv	SPIKE GLYCOPROTEIN,FIBRITI N (SARSr-CoV)	4 / 8	THR B 585 VAL B 594 GLU B 593 SER B 673	1.40A	22.78	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BZO_C_FI8C1201_2 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA RNA POLYMERASE SIGMA FACTOR SIGA)	6crv	SPIKE GLYCOPROTEIN,FIBRITI N (SARSr-CoV)	4 / 4	LEU C 615 ASP C 613 GLN C 614 VAL A 718	1.30A	18.16	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6C06_D_FI8D1404_1 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6crv	SPIKE GLYCOPROTEIN,FIBRITI N (SARSr-CoV)	3 / 3	ARG C 18 LYS C 18 ARG C 99	1.35A	23.70	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6C06_D_FI8D1404_1 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6crw	SPIKE GLYCOPROTEIN,FIBRITI N (SARSr-CoV)	3 / 3	ARG C 183 LYS C 198 ARG B 544	1.41A	23.41	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BZO_C_FI8C1201_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA)	6crx	SPIKE GLYCOPROTEIN,FIBRITI N (SARSr-CoV)	5 / 12	ILE B 72 THR B 71 THR B 92 SER B 95 GLU B 174	1.33A	22.81	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_1 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6cs0	SPIKE GLYCOPROTEIN,FIBRITI N (SARSr-CoV)	4 / 8	LYS B 333 ARG B 495 VAL B 354 GLN B 492	1.37A	23.46	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6C06_D_FI8D1404_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6cs0	SPIKE GLYCOPROTEIN,FIBRITI N (SARSr-CoV)	4 / 8	ILE A1086 THR A1087 GLN A1088 SER C1105	0.98A	22.81	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6cs1	SPIKE GLYCOPROTEIN,FIBRITI N (SARSr-CoV)	4 / 8	GLN C 744 THR B 943 VAL B 945 SER B 950	1.24A	22.79	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BZO_C_FI8C1201_2 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA RNA POLYMERASE SIGMA FACTOR SIGA)	6cs1	SPIKE GLYCOPROTEIN,FIBRITI N (SARSr-CoV)	4 / 4	LEU B 615 ASP B 613 GLN B 614 VAL C 718	1.17A	18.36	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BZO_C_FI8C1201_1 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6cs1	SPIKE GLYCOPROTEIN,FIBRITI N (SARSr-CoV)	5 / 9	LYS A 566 ARG A 315 GLU A 569 LEU A 538 PRO A 540	1.71A	23.41	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6C06_D_FI8D1404_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6iex	MHC CLASS I ANTIGEN (Homo sapiens)	4 / 8	THR A 69 GLN A 65 THR A 64 SER A 38	1.42A	13.69	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6C06_D_FI8D1404_1 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6jyt	HELICASE (SARSr-CoV)	3 / 3	ARG B 490 LYS B 524 ARG B 161	1.71A	17.56	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6C06_D_FI8D1404_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6jyt	HELICASE (SARSr-CoV)	4 / 8	ILE A 488 THR A 552 GLU A 551 SER A 577	1.45A	20.63	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6lxt	SPIKE PROTEIN S2 (SARS-CoV-2)	4 / 8	ILE D 934 THR F 941 LYS F 947 SER E 940	1.17A	8.12	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_1 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6lze	VIRAL PROTEASE (SARS-CoV-2)	4 / 8	ASP A 187 ARG A 40 VAL A 171 GLN A 110	1.68A	12.86	None DMS A 404 (-3.4A) None None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6lze	VIRAL PROTEASE (SARS-CoV-2)	4 / 8	MET A 6 GLN A 127 THR A 111 GLU A 290	1.67A	14.37	DMS A 402 (-3.9A) DMS A 402 (-3.4A) None None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6lze	VIRAL PROTEASE (SARS-CoV-2)	4 / 8	ILE A 200 GLN A 110 VAL A 104 SER A 113	1.71A	14.37	None None None DMS A 402 ( 4.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_1 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6m03	MAIN PROTEASE (SARS-CoV-2)	4 / 8	ASP A 176 ARG A 105 VAL A 13 ARG A 298	1.39A	13.60	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6m0k	VIRAL PROTEASE (SARS-CoV-2)	4 / 8	MET A 6 GLN A 127 THR A 111 GLU A 290	1.66A	16.04	DMS A 404 (-3.9A) DMS A 404 (-3.3A) None None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6m0k	VIRAL PROTEASE (SARS-CoV-2)	4 / 8	ILE A 200 GLN A 110 VAL A 104 SER A 113	1.73A	16.04	None None None DMS A 404 ( 4.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BZO_C_FI8C1201_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA)	6m17	SODIUM-DEPENDENT NEUTRAL AMINO ACID TRANSPORTER B(0)AT1 (Homo sapiens)	5 / 12	ILE C 576 THR C 559 VAL C 585 VAL C 584 SER C 487	1.47A	19.28	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_1 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6m17	SODIUM-DEPENDENT NEUTRAL AMINO ACID TRANSPORTER B(0)AT1 (Homo sapiens)	4 / 8	ASP A 173 ARG A 332 VAL A 324 GLN A 357	1.60A	18.84	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6m18	ACE2 (Homo sapiens)	4 / 8	ILE B 694 VAL B 487 LYS B 481 SER B 257	1.43A	20.77	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6m1d	SODIUM-DEPENDENT NEUTRAL AMINO ACID TRANSPORTER B(0)AT1 (Homo sapiens)	4 / 8	ILE C 305 THR C 313 VAL C 317 SER C 278	1.29A	19.40	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_1 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6m1d	ACE2 (Homo sapiens)	4 / 8	ARG D 219 GLU D 457 VAL D 506 GLN D 472	1.54A	20.58	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6m2n	3CL PROTEASE (SARS-CoV-2)	4 / 8	MET B 6 GLN B 127 THR B 111 GLU B 290	1.79A	15.60	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_1 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6m2n	3CL PROTEASE (SARS-CoV-2)	4 / 8	ASP D 187 ARG D 40 VAL D 171 GLN D 110	1.66A	13.60	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6m2n	3CL PROTEASE (SARS-CoV-2)	4 / 8	ILE A 281 THR A 304 VAL A 303 SER A 1	1.48A	15.60	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_1 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6m2n	3CL PROTEASE (SARS-CoV-2)	4 / 8	ASP B 187 ARG B 40 VAL B 171 GLN B 110	1.61A	13.60	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6m2n	3CL PROTEASE (SARS-CoV-2)	4 / 8	ILE B 281 THR B 304 VAL B 303 SER B 1	1.56A	15.60	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6C06_D_FI8D1404_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6m2n	3CL PROTEASE (SARS-CoV-2)	4 / 8	ILE C 281 THR C 280 GLU A 288 SER A 284	1.28A	12.99	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_1 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6m2n	3CL PROTEASE (SARS-CoV-2)	4 / 8	ASP B 33 LYS B 100 VAL B 104 GLN A 244	1.77A	13.60	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6C06_D_FI8D1404_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6m2n	3CL PROTEASE (SARS-CoV-2)	4 / 8	ILE D 281 THR D 280 GLU B 288 SER B 284	1.38A	12.99	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_1 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6m2n	3CL PROTEASE (SARS-CoV-2)	4 / 8	ASP A 187 ARG A 40 VAL A 171 GLN A 110	1.57A	13.60	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6m2q	3CL PROTEASE (SARS-CoV-2)	4 / 8	GLN A 19 THR A 26 VAL A 42 SER A 147	1.62A	15.60	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_1 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6m2q	3CL PROTEASE (SARS-CoV-2)	4 / 8	ASP A 187 ARG A 40 VAL A 171 GLN A 110	1.65A	13.60	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6m71	NSP12 (SARS-CoV-2)	4 / 8	ILE A 466 GLN A 468 THR A 701 VAL A 700	1.60A	21.59	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6m71	NSP12 (SARS-CoV-2)	4 / 8	MET A 755 ILE A 757 GLU A 811 SER A 814	1.26A	21.59	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6m71	NSP12 (SARS-CoV-2)	4 / 8	GLN A 789 THR A 701 VAL A 704 SER A 784	1.69A	21.59	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6m71	NSP12 (SARS-CoV-2)	4 / 8	GLN A 698 THR A 701 VAL A 704 SER A 784	1.75A	21.59	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BZO_C_FI8C1201_2 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA RNA POLYMERASE SIGMA FACTOR SIGA)	6m71	NSP7 NSP8 (SARS-CoV-2)	4 / 4	LEU C 35 ASP C 38 GLN C 34 VAL D 130	1.58A	9.79	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6m71	NSP12 (SARS-CoV-2)	4 / 8	GLN A 661 THR A 538 GLU A 665 SER A 664	1.15A	21.59	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_1 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6m71	NSP12 (SARS-CoV-2)	5 / 8	ARG A 735 ARG A 305 GLU A 474 VAL A 476 ARG A 651	1.66A	21.10	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6C06_D_FI8D1404_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6m71	NSP12 NSP8 (SARS-CoV-2)	4 / 8	ILE A 450 THR A 393 THR B 137 LYS B 139	1.62A	21.78	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6m71	NSP12 (SARS-CoV-2)	4 / 8	ILE A 244 THR A 319 VAL A 320 GLU A 254	1.48A	21.59	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_1 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6m71	NSP12 (SARS-CoV-2)	4 / 8	ARG A 836 ARG A 555 VAL A 410 ARG A 624	1.75A	21.10	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BZO_C_FI8C1201_2 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA RNA POLYMERASE SIGMA FACTOR SIGA)	6m71	NSP12 (SARS-CoV-2)	4 / 4	LEU A 240 ASP A 465 GLN A 468 VAL A 31	1.64A	19.49	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6C06_D_FI8D1404_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6m71	NSP12 (SARS-CoV-2)	4 / 8	THR A 409 GLN A 408 THR A 556 SER A 451	1.47A	21.78	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_1 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6m71	NSP12 (SARS-CoV-2)	4 / 8	ASP A 126 ARG A 33 LYS A 31 VAL A 42	1.62A	21.10	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6C06_D_FI8D1404_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6m71	NSP12 (SARS-CoV-2)	4 / 8	ILE A 562 THR A 565 THR A 531 ARG A 654	1.56A	21.78	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_1 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6m71	NSP12 (SARS-CoV-2)	4 / 8	ASP A 258 ARG A 183 GLU A 254 GLN A 210	1.39A	21.10	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6C06_D_FI8D1404_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6nb6	SPIKE GLYCOPROTEIN (SARSr-CoV)	4 / 8	ILE C1086 THR C1087 THR C 894 SER A1105	1.12A	23.44	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_1 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6nb6	SPIKE GLYCOPROTEIN (SARSr-CoV)	4 / 8	ARG B 747 ARG C 996 VAL C 842 GLN A 992	1.49A	23.45	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6nb6	SPIKE GLYCOPROTEIN (SARSr-CoV)	4 / 8	THR C 585 VAL C 594 GLU C 593 SER C 673	1.28A	23.19	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BZO_C_FI8C1201_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA)	6nb7	SPIKE GLYCOPROTEIN (SARSr-CoV)	5 / 12	ILE A 995 GLN A 993 THR A 716 VAL A 842 VAL A 933	1.66A	23.44	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BZO_C_FI8C1201_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA)	6nb8	S230 ANTIGEN-BINDING (FAB) FRAGMENT, LIGHT CHAIN (Homo sapiens)	5 / 12	THR L 5 GLN L 6 THR L 107 VAL L 90 VAL L 109	1.49A	10.90	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6nur	NSP12 (SARSr-CoV)	4 / 8	GLN A 661 THR A 538 GLU A 665 SER A 664	1.11A	21.25	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BZO_C_FI8C1201_2 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA RNA POLYMERASE SIGMA FACTOR SIGA)	6nur	NSP7 NSP8 (SARSr-CoV)	4 / 4	LEU C 35 ASP C 38 GLN C 34 VAL D 130	1.77A	10.17	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6C06_D_FI8D1404_1 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6nus	NSP12 NSP8 (SARSr-CoV)	3 / 3	ARG B 80 LYS A 369 ARG A 654	1.31A	9.20	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BZO_C_FI8C1201_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA)	6nus	NSP12 (SARSr-CoV)	5 / 12	MET A 566 ILE A 562 GLU A 658 VAL A 662 GLU A 665	1.69A	22.27	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_1 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6nus	NSP12 (SARSr-CoV)	4 / 8	ASP A 258 ARG A 183 GLU A 254 GLN A 210	1.45A	21.82	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BZO_C_FI8C1201_2 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA RNA POLYMERASE SIGMA FACTOR SIGA)	6vsb	SPIKE GLYCOPROTEIN (SARS-CoV-2)	4 / 4	LEU A 582 ASP A 578 GLN A 580 VAL B 126	1.35A	16.30	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BZO_C_FI8C1201_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA)	6vsb	SPIKE GLYCOPROTEIN (SARS-CoV-2)	5 / 12	GLN C1106 THR C1105 VAL C1104 VAL C1096 GLU B1092	1.36A	23.35	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_1 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6vsb	SPIKE GLYCOPROTEIN (SARS-CoV-2)	4 / 8	ASP B 290 VAL B 597 ARG C 765 GLN B 957	1.61A	23.29	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6vsb	SPIKE GLYCOPROTEIN (SARS-CoV-2)	4 / 8	GLN A1106 THR A1105 VAL A1104 GLU A1092	1.44A	22.87	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6C06_D_FI8D1404_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6vw1	ACE2 (Homo sapiens)	4 / 8	ILE A 119 THR A 118 LYS A 74 SER A 109	1.29A	18.89	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6C06_D_FI8D1404_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6vww	URIDYLATE-SPECIFIC ENDORIBONUCLEASE (SARS-CoV-2)	4 / 8	ILE B 281 THR B 282 THR B 286 SER B 244	1.21A	16.29	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6C06_D_FI8D1404_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6vxs	NSP3 (SARS-CoV-2)	4 / 8	ILE A 106 THR A 146 GLU A 114 SER A 111	1.62A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6C06_D_FI8D1404_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6vxs	NSP3 (SARS-CoV-2)	4 / 8	ILE B 106 THR B 146 GLU B 114 SER B 111	1.78A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6vxx	SPIKE GLYCOPROTEIN (SARS-CoV-2)	4 / 8	ILE A 312 GLN A 613 LYS B 854 SER A 316	1.27A	23.09	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6vyb	SPIKE GLYCOPROTEIN (SARS-CoV-2)	4 / 8	ILE A 312 GLN A 613 LYS B 854 SER A 316	1.29A	22.42	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BZO_C_FI8C1201_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA)	6w01	URIDYLATE-SPECIFIC ENDORIBONUCLEASE (SARS-CoV-2)	5 / 12	ILE A 116 THR B 121 VAL B 78 VAL B 142 SER B 98	1.54A	16.29	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_1 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6w41	SPIKE PROTEIN S1 (SARS-CoV-2)	4 / 8	ARG C 403 GLU C 406 VAL C 350 GLN C 498	1.77A	8.77	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6w41	CR3022 FAB LIGHT CHAIN (Homo sapiens)	4 / 8	ILE L 117 VAL L 163 GLU L 161 SER L 159	1.71A	9.46	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BZO_C_FI8C1201_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA)	6w41	CR3022 FAB LIGHT CHAIN (Homo sapiens)	5 / 12	THR L 5 GLN L 6 THR L 102 VAL L 85 VAL L 104	1.40A	8.26	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6C06_D_FI8D1404_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6w41	CR3022 FAB HEAVY CHAIN CR3022 FAB LIGHT CHAIN (Homo sapiens)	4 / 8	ILE H 51 THR H 57 THR L 94 SER H 60	1.78A	8.56	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_1 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6w41	CR3022 FAB HEAVY CHAIN CR3022 FAB LIGHT CHAIN SPIKE PROTEIN S1 (Homo sapiens; SARS-CoV-2)	4 / 8	ASP C 389 GLU L 55 VAL H 102 GLN L 90	1.76A	8.77	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6w41	CR3022 FAB LIGHT CHAIN (Homo sapiens)	4 / 8	ILE L 48 VAL L 13 LYS L 107 SER L 77	1.49A	9.46	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6w41	CR3022 FAB LIGHT CHAIN (Homo sapiens)	4 / 8	ILE L 48 VAL L 13 LYS L 107 SER L 76	1.58A	9.46	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6w4h	NSP16 (SARS-CoV-2)	4 / 8	ILE A6967 THR A6993 VAL A6995 SER A7000	1.43A	13.36	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6w61	2'-O-METHYLTRANSFERA SE (SARS-CoV-2)	4 / 8	ILE A6967 THR A6993 VAL A6995 SER A7000	1.42A		None None None KCX A6935 ( 3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BZO_C_FI8C1201_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA)	6w61	2'-O-METHYLTRANSFERA SE (SARS-CoV-2)	5 / 12	ILE A6838 GLN A6847 THR A6993 VAL A6807 GLU A7001	1.78A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BZO_C_FI8C1201_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA)	6w61	2'-O-METHYLTRANSFERA SE (SARS-CoV-2)	5 / 12	ILE A6838 GLN A6847 THR A6993 VAL A6992 VAL A6807	1.75A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BZO_C_FI8C1201_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA)	6w61	2'-O-METHYLTRANSFERA SE (SARS-CoV-2)	5 / 12	THR A6846 GLN A6847 THR A6993 VAL A6992 VAL A6807	1.78A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BZO_C_FI8C1201_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA)	6w61	2'-O-METHYLTRANSFERA SE (SARS-CoV-2)	5 / 12	THR A6846 GLN A6847 THR A6993 VAL A6807 GLU A7001	1.80A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6w61	NSP10 (SARS-CoV-2)	4 / 8	ILE B4352 GLN B4351 THR B4309 VAL B4310	1.68A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6w61	2'-O-METHYLTRANSFERA SE (SARS-CoV-2)	4 / 8	ILE A6838 THR A6993 VAL A6992 SER A6998	1.80A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6C06_D_FI8D1404_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6w61	2'-O-METHYLTRANSFERA SE (SARS-CoV-2)	4 / 8	THR A6846 GLN A6847 THR A6993 GLU A7001	1.77A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6w63	3C-LIKE PROTEINASE (SARS-CoV-2)	4 / 8	MET A 6 GLN A 127 THR A 111 GLU A 290	1.70A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6C06_D_FI8D1404_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6w6y	NSP3 (SARS-CoV-2)	4 / 8	ILE A 106 THR A 146 GLU A 114 SER A 111	1.61A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6w75	NSP16 (SARS-CoV-2)	4 / 8	ILE C6967 THR C6993 VAL C6995 SER C7000	1.44A	8.71	None None None FMT C7110 ( 2.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BZO_C_FI8C1201_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA)	6w75	NSP16 (SARS-CoV-2)	5 / 12	THR C6846 GLN C6847 THR C6993 VAL C6992 VAL C6807	1.80A	8.38	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6w75	NSP10 (SARS-CoV-2)	4 / 8	ILE D4352 GLN D4351 THR D4309 VAL D4310	1.75A	8.59	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BZO_C_FI8C1201_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA)	6w75	NSP16 (SARS-CoV-2)	5 / 12	ILE C6838 GLN C6847 THR C6993 VAL C6807 GLU C7001	1.79A	8.38	None None None None FMT C7108 ( 3.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BZO_C_FI8C1201_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA)	6w75	NSP16 (SARS-CoV-2)	5 / 12	ILE A6838 GLN A6847 THR A6993 VAL A6992 VAL A6807	1.78A	8.38	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6w75	NSP16 (SARS-CoV-2)	4 / 8	ILE A6967 THR A6993 VAL A6995 SER A7000	1.44A	8.71	None None None FMT A7105 ( 2.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6C06_D_FI8D1404_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6w75	NSP16 (SARS-CoV-2)	4 / 8	THR A6846 GLN A6847 THR A6993 GLU A7001	1.79A	8.38	None None None FMT A7104 ( 4.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BZO_C_FI8C1201_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA)	6w75	NSP16 (SARS-CoV-2)	5 / 12	ILE A6838 GLN A6847 THR A6993 VAL A6807 GLU A7001	1.80A	8.38	None None None None FMT A7104 ( 4.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BZO_C_FI8C1201_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA)	6w75	NSP16 (SARS-CoV-2)	5 / 12	ILE C6838 GLN C6847 THR C6993 VAL C6992 VAL C6807	1.78A	8.38	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6C06_D_FI8D1404_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6w75	NSP16 (SARS-CoV-2)	4 / 8	THR C6846 GLN C6847 THR C6993 GLU C7001	1.78A	8.38	None None None FMT C7108 ( 3.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6w75	NSP16 (SARS-CoV-2)	4 / 8	ILE C6838 THR C6993 VAL C6992 SER C6998	1.80A	8.71	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6w75	NSP10 (SARS-CoV-2)	4 / 8	ILE B4352 GLN B4351 THR B4309 VAL B4310	1.76A	8.59	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6w75	NSP16 (SARS-CoV-2)	4 / 8	ILE C6838 GLN C6847 VAL C6992 GLU C7001	1.70A	8.71	None None None FMT C7108 ( 3.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BZO_C_FI8C1201_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA)	6w9c	PAPAIN-LIKE PROTEINASE (SARS-CoV-2)	5 / 12	MET B 25 THR B 34 VAL B 57 VAL B 7 GLU B 51	1.65A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6C06_D_FI8D1404_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6w9c	PAPAIN-LIKE PROTEINASE (SARS-CoV-2)	4 / 8	ILE C 276 THR C 277 THR C 119 SER C 103	1.45A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BZO_C_FI8C1201_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA)	6w9c	PAPAIN-LIKE PROTEINASE (SARS-CoV-2)	6 / 12	ILE C 123 THR C 119 GLN C 122 THR C 277 LYS C 292 SER C 103	1.79A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6C06_D_FI8D1404_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6w9c	PAPAIN-LIKE PROTEINASE (SARS-CoV-2)	4 / 8	ILE A 276 THR A 277 THR A 119 SER A 103	1.53A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6w9c	PAPAIN-LIKE PROTEINASE (SARS-CoV-2)	4 / 8	ILE A 314 VAL A 242 GLU A 307 SER A 309	1.39A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6w9c	PAPAIN-LIKE PROTEINASE (SARS-CoV-2)	4 / 8	GLN C 236 THR C 311 GLU C 307 SER C 239	1.78A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6C06_D_FI8D1404_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6w9c	PAPAIN-LIKE PROTEINASE (SARS-CoV-2)	4 / 8	ILE B 276 THR B 277 THR B 119 SER B 103	1.51A		None None None CL B 502 ( 4.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6w9c	PAPAIN-LIKE PROTEINASE (SARS-CoV-2)	4 / 8	ILE C 314 VAL C 242 GLU C 307 SER C 309	1.45A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6w9c	PAPAIN-LIKE PROTEINASE (SARS-CoV-2)	4 / 8	ILE B 314 VAL B 242 GLU B 307 SER B 309	1.33A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6w9c	PAPAIN-LIKE PROTEINASE (SARS-CoV-2)	4 / 8	GLN A 236 THR A 311 GLU A 307 SER A 239	1.70A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6C06_D_FI8D1404_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6wcf	NSP3 (SARS-CoV-2)	4 / 8	ILE A 106 THR A 146 GLU A 114 SER A 111	1.70A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6C06_D_FI8D1404_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6wen	NSP3 (SARS-CoV-2)	4 / 8	ILE A 106 THR A 146 GLU A 114 SER A 111	1.79A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6C06_D_FI8D1404_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6wey	NSP3 (SARS-CoV-2)	4 / 8	ILE A 310 THR A 350 GLU A 318 SER A 315	1.73A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6wiq	NSP7 NSP8 (SARS-CoV-2)	4 / 8	ILE A 68 GLN B 88 THR B 84 VAL B 83	1.67A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_1 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6wji	NUCLEOCAPSID PROTEIN (SARS-CoV-2)	4 / 8	ASP B 343 ARG E 293 LYS E 266 GLN B 294	1.63A	6.61	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6C06_D_FI8D1404_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6wji	NUCLEOCAPSID PROTEIN (SARS-CoV-2)	4 / 8	ILE A 337 THR B 332 THR B 282 SER B 327	1.70A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6C06_D_FI8D1404_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6wjt	2'-O-METHYLTRANSFERA SE (SARS-CoV-2)	4 / 8	THR C6846 GLN C6847 THR C6993 GLU C7001	1.78A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BZO_C_FI8C1201_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA)	6wjt	2'-O-METHYLTRANSFERA SE (SARS-CoV-2)	5 / 12	ILE A6838 GLN A6847 THR A6993 VAL A6992 VAL A6807	1.78A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6wjt	NSP10 (SARS-CoV-2)	4 / 8	ILE B4352 GLN B4351 THR B4309 VAL B4310	1.75A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6wjt	2'-O-METHYLTRANSFERA SE (SARS-CoV-2)	4 / 8	ILE C6967 THR C6993 VAL C6995 SER C7000	1.44A		None None None FMT C7104 ( 3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6wjt	2'-O-METHYLTRANSFERA SE (SARS-CoV-2)	4 / 8	ILE A6838 THR A6993 VAL A6992 SER A6998	1.79A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6wjt	2'-O-METHYLTRANSFERA SE (SARS-CoV-2)	4 / 8	ILE A6838 GLN A6847 VAL A6992 GLU A7001	1.70A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6wjt	2'-O-METHYLTRANSFERA SE (SARS-CoV-2)	4 / 8	ILE C6838 GLN C6847 VAL C6992 GLU C7001	1.67A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6C06_D_FI8D1404_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6wjt	2'-O-METHYLTRANSFERA SE (SARS-CoV-2)	4 / 8	THR A6846 GLN A6847 THR A6993 GLU A7001	1.78A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BZO_C_FI8C1201_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA)	6wjt	2'-O-METHYLTRANSFERA SE (SARS-CoV-2)	5 / 12	ILE A6838 GLN A6847 THR A6993 VAL A6807 GLU A7001	1.79A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BZO_C_FI8C1201_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA)	6wjt	2'-O-METHYLTRANSFERA SE (SARS-CoV-2)	5 / 12	ILE C6838 GLN C6847 THR C6993 VAL C6992 VAL C6807	1.78A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6C06_D_FI8D1404_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6wjt	2'-O-METHYLTRANSFERA SE NSP10 (SARS-CoV-2)	4 / 8	THR D4302 LYS C6836 GLU D4319 SER D4320	1.75A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6wjt	2'-O-METHYLTRANSFERA SE (SARS-CoV-2)	4 / 8	ILE A6967 THR A6993 VAL A6995 SER A7000	1.45A		None None None FMT A7104 ( 2.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6wjt	2'-O-METHYLTRANSFERA SE (SARS-CoV-2)	4 / 8	ILE C6838 THR C6993 VAL C6992 SER C6998	1.80A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BZO_C_FI8C1201_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA)	6wjt	2'-O-METHYLTRANSFERA SE (SARS-CoV-2)	5 / 12	ILE C6838 GLN C6847 THR C6993 VAL C6807 GLU C7001	1.78A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6wjt	NSP10 (SARS-CoV-2)	4 / 8	ILE D4352 GLN D4351 THR D4309 VAL D4310	1.75A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6C06_D_FI8D1404_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6wkq	NSP16 (SARS-CoV-2)	4 / 8	THR C6846 GLN C6847 THR C6993 GLU C7001	1.78A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6wkq	NSP16 (SARS-CoV-2)	4 / 8	ILE C6967 THR C6993 VAL C6995 SER C7000	1.44A		None None None FMT C7110 ( 3.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6wkq	NSP16 (SARS-CoV-2)	4 / 8	ILE A6838 GLN A6847 VAL A6992 GLU A7001	1.71A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6wkq	NSP16 (SARS-CoV-2)	4 / 8	ILE A6967 THR A6993 VAL A6995 SER A7000	1.44A		None None None FMT A7106 ( 2.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6wkq	NSP10 (SARS-CoV-2)	4 / 8	ILE B4352 GLN B4351 THR B4309 VAL B4310	1.75A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6wkq	NSP10 (SARS-CoV-2)	4 / 8	ILE D4352 GLN D4351 THR D4309 VAL D4310	1.74A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BZO_C_FI8C1201_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA)	6wkq	NSP16 (SARS-CoV-2)	5 / 12	ILE A6838 GLN A6847 THR A6993 VAL A6992 VAL A6807	1.79A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6wkq	NSP16 (SARS-CoV-2)	4 / 8	ILE C6838 GLN C6847 VAL C6992 GLU C7001	1.70A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BZO_C_FI8C1201_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA)	6wkq	NSP16 (SARS-CoV-2)	5 / 12	ILE C6838 GLN C6847 THR C6993 VAL C6992 VAL C6807	1.80A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6C06_D_FI8D1404_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6wkq	NSP16 (SARS-CoV-2)	4 / 8	THR A6846 GLN A6847 THR A6993 GLU A7001	1.79A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6wlc	URIDYLATE-SPECIFIC ENDORIBONUCLEASE (SARS-CoV-2)	4 / 8	ILE A 72 THR A 175 VAL A 173 GLU A 146	1.64A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BZO_C_FI8C1201_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA)	6wlc	URIDYLATE-SPECIFIC ENDORIBONUCLEASE (SARS-CoV-2)	5 / 12	ILE A 116 THR B 121 VAL B 78 VAL B 142 SER B 98	1.56A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BZO_C_FI8C1201_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA)	6wlc	URIDYLATE-SPECIFIC ENDORIBONUCLEASE (SARS-CoV-2)	5 / 12	ILE B 116 THR A 121 VAL A 78 VAL A 142 SER A 98	1.64A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6C06_D_FI8D1404_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6wlc	URIDYLATE-SPECIFIC ENDORIBONUCLEASE (SARS-CoV-2)	4 / 8	ILE B 281 THR B 282 THR B 286 SER B 244	1.32A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BZO_C_FI8C1201_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA)	6wlc	URIDYLATE-SPECIFIC ENDORIBONUCLEASE (SARS-CoV-2)	5 / 12	ILE A 86 THR A 84 VAL A 6 VAL A 10 GLU A 57	1.70A		None None None None EDO A 403 (-3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6wlc	URIDYLATE-SPECIFIC ENDORIBONUCLEASE (SARS-CoV-2)	4 / 8	ILE B 72 THR B 175 VAL B 173 GLU B 146	1.78A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BZO_C_FI8C1201_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA)	6wlc	URIDYLATE-SPECIFIC ENDORIBONUCLEASE (SARS-CoV-2)	5 / 12	ILE B 86 THR B 84 VAL B 6 VAL B 10 GLU B 57	1.70A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6wlc	URIDYLATE-SPECIFIC ENDORIBONUCLEASE (SARS-CoV-2)	4 / 8	ILE A 116 THR B 121 VAL B 78 SER B 98	1.57A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6C06_D_FI8D1404_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6wlc	URIDYLATE-SPECIFIC ENDORIBONUCLEASE (SARS-CoV-2)	4 / 8	ILE A 281 THR A 282 THR A 286 SER A 244	1.34A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6wnp	3C-LIKE PROTEINASE (SARS-CoV-2)	4 / 8	MET A 6 GLN A 127 THR A 111 GLU A 290	1.71A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6wnp	3C-LIKE PROTEINASE (SARS-CoV-2)	4 / 8	ILE A 200 GLN A 110 VAL A 104 SER A 113	1.79A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6C06_D_FI8D1404_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6woj	REPLICASE POLYPROTEIN 1AB (SARS-CoV-2)	4 / 8	ILE C 106 THR C 146 GLU C 114 SER C 111	1.79A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6C06_D_FI8D1404_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6woj	REPLICASE POLYPROTEIN 1AB (SARS-CoV-2)	4 / 8	ILE A 106 THR A 146 GLU A 114 SER A 111	1.72A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BZO_C_FI8C1201_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA)	6wq3	2'-O-METHYLTRANSFERA SE (SARS-CoV-2)	5 / 12	ILE A6838 GLN A6847 THR A6993 VAL A6992 VAL A6807	1.79A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6C06_D_FI8D1404_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6wq3	2'-O-METHYLTRANSFERA SE (SARS-CoV-2)	4 / 8	THR A6846 GLN A6847 THR A6993 GLU A7001	1.79A		None None None GTA A7102 (-4.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6wq3	2'-O-METHYLTRANSFERA SE (SARS-CoV-2)	4 / 8	ILE A6967 THR A6993 VAL A6995 SER A7000	1.53A		None None None GTA A7102 (-2.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6wq3	2'-O-METHYLTRANSFERA SE (SARS-CoV-2)	4 / 8	ILE A6838 THR A6993 VAL A6992 SER A6998	1.80A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6wq3	2'-O-METHYLTRANSFERA SE (SARS-CoV-2)	4 / 8	ILE A6838 GLN A6847 VAL A6992 GLU A7001	1.69A		None None None GTA A7102 (-4.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6wq3	NSP10 (SARS-CoV-2)	4 / 8	ILE B4352 GLN B4351 THR B4309 VAL B4310	1.73A		None None SO4 B4404 (-3.8A) SO4 B4404 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BZO_C_FI8C1201_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA)	6wq3	2'-O-METHYLTRANSFERA SE (SARS-CoV-2)	5 / 12	ILE A6838 GLN A6847 THR A6993 VAL A6807 GLU A7001	1.80A		None None None None GTA A7102 (-4.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6wqd	NSP8 (SARS-CoV-2)	4 / 8	GLN D 88 THR D 84 VAL D 83 LYS D 79	1.72A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6wqd	NSP7 (SARS-CoV-2)	4 / 8	GLN C 63 VAL C 66 LYS C 70 SER C 57	1.56A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BZO_C_FI8C1201_2 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA RNA POLYMERASE SIGMA FACTOR SIGA)	6wqd	NSP7 NSP8 (SARS-CoV-2)	4 / 4	LEU C 35 ASP C 38 GLN C 34 VAL D 130	1.66A	9.98	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BZO_C_FI8C1201_2 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA RNA POLYMERASE SIGMA FACTOR SIGA)	6wqd	NSP7 NSP8 (SARS-CoV-2)	4 / 4	LEU A 35 ASP A 38 GLN A 34 VAL B 186	1.70A	9.98	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6wqd	NSP8 (SARS-CoV-2)	4 / 8	GLN B 88 THR B 84 VAL B 83 LYS B 79	1.73A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6wqd	NSP7 (SARS-CoV-2)	4 / 8	GLN A 63 VAL A 66 LYS A 70 SER A 57	1.54A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_1 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6wqf	3C-LIKE PROTEINASE (SARS-CoV-2)	4 / 8	ASP A 187 ARG A 40 VAL A 171 GLN A 110	1.68A	13.60	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6C06_D_FI8D1404_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6wrh	PEPTIDASE C16 (SARS-CoV-2)	4 / 8	ILE A 276 THR A 277 THR A 119 SER A 103	1.50A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6wrh	PEPTIDASE C16 (SARS-CoV-2)	4 / 8	ILE A 314 VAL A 242 GLU A 307 SER A 309	1.45A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6C06_D_FI8D1404_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6wrh	PEPTIDASE C16 (SARS-CoV-2)	4 / 8	ILE A 123 THR A 119 THR A 168 LYS A 157	1.79A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6C06_D_FI8D1404_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6y2g	REPLICASE POLYPROTEIN 1AB (SARS-CoV-2)	4 / 8	ILE A 281 THR A 280 GLU B 288 SER B 284	1.34A	12.99	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6y7m	Replicase polyprotein 1a (SARSr-CoV)	4 / 8	ILE A 281 THR A 304 VAL A 303 SER A 1	1.38A	13.38	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6yb7	REPLICASE POLYPROTEIN 1AB (SARS-CoV-2)	4 / 8	MET A 6 GLN A 127 THR A 111 GLU A 290	1.77A	8.36	None DMS A 403 (-3.4A) None None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6yhu	REPLICASE POLYPROTEIN 1A (SARS-CoV-2)	4 / 8	GLN C 63 VAL C 66 LYS C 70 SER C 57	1.68A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6yhu	REPLICASE POLYPROTEIN 1A (SARS-CoV-2)	4 / 8	MET A 3 THR A 9 VAL A 12 SER C 4	1.76A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6yhu	REPLICASE POLYPROTEIN 1A (SARS-CoV-2)	4 / 8	MET C 3 THR C 9 VAL C 12 SER A 4	1.71A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6C06_D_FI8D1404_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6yhu	REPLICASE POLYPROTEIN 1A (SARS-CoV-2)	4 / 8	ILE B 156 THR B 187 GLN B 157 THR B 124	1.68A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BZO_C_FI8C1201_2 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA RNA POLYMERASE SIGMA FACTOR SIGA)	6yhu	REPLICASE POLYPROTEIN 1A (SARS-CoV-2)	4 / 4	LEU A 35 ASP A 38 GLN A 34 VAL B 186	1.63A	9.48	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6yhu	REPLICASE POLYPROTEIN 1A (SARS-CoV-2)	4 / 8	GLN D 88 THR D 84 VAL D 83 LYS D 79	1.71A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6yla	HEAVY CHAIN (Homo sapiens)	4 / 8	ILE B 76 THR H 155 VAL H 202 SER H 160	1.77A		None MLI H 305 ( 4.1A) None None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BZO_C_FI8C1201_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA)	6yla	HEAVY CHAIN LIGHT CHAIN (Homo sapiens)	5 / 12	THR B 169 VAL B 185 VAL B 186 SER C 168 VAL B 173	1.77A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6yla	LIGHT CHAIN (Homo sapiens)	4 / 8	ILE C 123 VAL C 169 GLU C 167 SER C 165	1.70A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_1 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6yla	HEAVY CHAIN LIGHT CHAIN SPIKE GLYCOPROTEIN (Homo sapiens; SARS-CoV-2)	4 / 8	ASP E 389 GLU L 61 VAL H 108 GLN L 96	1.54A	11.29	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BZO_C_FI8C1201_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA)	6yla	LIGHT CHAIN (Homo sapiens)	5 / 12	THR L 5 GLN L 6 THR L 108 VAL L 91 VAL L 110	1.46A		None None None 1PE L1603 ( 4.8A) None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6C06_D_FI8D1404_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6yla	HEAVY CHAIN LIGHT CHAIN (Homo sapiens)	4 / 8	ILE H 51 THR H 58 THR L 100 SER H 61	1.70A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6yla	HEAVY CHAIN (Homo sapiens)	4 / 8	ILE B 20 THR H 155 VAL H 156 SER H 160	1.39A		None MLI H 305 ( 4.1A) None None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BZO_C_FI8C1201_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA)	6yla	HEAVY CHAIN LIGHT CHAIN (Homo sapiens)	5 / 12	THR H 169 VAL H 185 VAL H 186 SER L 168 VAL H 173	1.79A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6C06_D_FI8D1404_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6yla	HEAVY CHAIN LIGHT CHAIN SPIKE GLYCOPROTEIN (Homo sapiens; SARS-CoV-2)	4 / 8	THR B 0 GLN B 1 THR A 385 SER C 62	1.79A		MLI B 303 (-4.2A) None None MLI B 303 ( 3.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6yla	HEAVY CHAIN LIGHT CHAIN (Homo sapiens)	4 / 8	ILE C 123 VAL B 215 LYS B 214 SER B 183	1.65A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6yla	HEAVY CHAIN LIGHT CHAIN (Homo sapiens)	4 / 8	ILE B 76 THR L 170 VAL L 169 SER L 177	1.70A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6yla	HEAVY CHAIN (Homo sapiens)	4 / 8	ILE B 76 THR H 155 VAL H 154 SER H 184	1.54A		None MLI H 305 ( 4.1A) None None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BZO_C_FI8C1201_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA)	6yla	HEAVY CHAIN LIGHT CHAIN SPIKE GLYCOPROTEIN (Homo sapiens; SARS-CoV-2)	5 / 12	THR B 31 THR A 376 VAL A 407 SER A 373 GLU L 87	1.79A		None None DMS A 903 ( 4.7A) DMS A 901 (-3.6A) None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6C06_D_FI8D1404_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6yla	HEAVY CHAIN LIGHT CHAIN (Homo sapiens)	4 / 8	THR B 0 GLN B 1 GLU C 61 SER C 62	1.19A		MLI B 303 (-4.2A) None None MLI B 303 ( 3.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_1 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6yla	HEAVY CHAIN LIGHT CHAIN SPIKE GLYCOPROTEIN (Homo sapiens; SARS-CoV-2)	4 / 8	ASP A 389 GLU C 61 VAL B 108 GLN C 96	1.58A	11.29	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6C06_D_FI8D1404_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6yla	HEAVY CHAIN LIGHT CHAIN (Homo sapiens)	4 / 8	ILE B 51 THR B 58 THR C 100 SER B 61	1.73A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6yla	LIGHT CHAIN (Homo sapiens)	4 / 8	ILE L 123 VAL L 169 GLU L 167 SER L 165	1.68A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6C06_D_FI8D1404_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6yla	HEAVY CHAIN LIGHT CHAIN (Homo sapiens)	4 / 8	THR H 0 GLN H 1 GLU L 61 SER L 62	1.15A		MLI B 303 (-4.8A) None None MLI B 303 (-3.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6yla	HEAVY CHAIN LIGHT CHAIN (Homo sapiens)	4 / 8	ILE L 123 VAL H 215 LYS H 214 SER H 183	1.66A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BZO_C_FI8C1201_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA)	6yla	LIGHT CHAIN (Homo sapiens)	5 / 12	THR C 5 GLN C 6 THR C 108 VAL C 91 VAL C 110	1.47A		None None None 1PE C 301 (-4.9A) None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BZO_C_FI8C1201_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA)	6ym0	LIGHT CHAIN (Homo sapiens)	5 / 12	THR L 5 GLN L 6 THR L 108 VAL L 91 VAL L 110	1.51A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BZO_C_FI8C1201_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA)	6ym0	HEAVY CHAIN LIGHT CHAIN (Homo sapiens)	5 / 12	THR H 169 VAL H 185 VAL H 186 SER L 168 VAL H 173	1.80A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_1 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6ym0	HEAVY CHAIN LIGHT CHAIN SPIKE GLYCOPROTEIN (Homo sapiens; SARS-CoV-2)	4 / 8	ASP E 389 GLU L 61 VAL H 108 GLN L 96	1.48A	11.29	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6ym0	HEAVY CHAIN LIGHT CHAIN (Homo sapiens)	4 / 8	ILE L 123 VAL H 215 LYS H 214 SER H 183	1.75A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6C06_D_FI8D1404_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6ym0	HEAVY CHAIN LIGHT CHAIN (Homo sapiens)	4 / 8	ILE H 51 THR H 58 THR L 100 SER H 61	1.71A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_1 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6ynq	REPLICASE POLYPROTEIN 1AB (SARS-CoV-2)	4 / 8	ASP A 187 ARG A 40 VAL A 171 GLN A 110	1.65A	13.60	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6ynq	REPLICASE POLYPROTEIN 1AB (SARS-CoV-2)	4 / 8	MET A 6 GLN A 127 THR A 111 GLU A 290	1.75A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_1 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6yor	IGG H CHAIN IGG L CHAIN SPIKE GLYCOPROTEIN (Homo sapiens; SARS-CoV-2)	4 / 8	ASP A 389 GLU C 61 VAL B 108 GLN C 96	1.54A	10.07	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6yor	IGG L CHAIN (Homo sapiens)	4 / 8	ILE C 123 VAL C 169 GLU C 167 SER C 165	1.69A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BZO_C_FI8C1201_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA)	6yor	IGG H CHAIN IGG L CHAIN (Homo sapiens)	5 / 12	THR H 169 VAL H 185 VAL H 186 SER L 168 VAL H 173	1.78A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BZO_C_FI8C1201_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA)	6yor	IGG H CHAIN IGG L CHAIN (Homo sapiens)	5 / 12	THR B 169 VAL B 185 VAL B 186 SER C 168 VAL B 173	1.78A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BZO_C_FI8C1201_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA)	6yor	IGG L CHAIN (Homo sapiens)	5 / 12	THR C 5 GLN C 6 THR C 108 VAL C 91 VAL C 110	1.47A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6C06_D_FI8D1404_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6yor	IGG H CHAIN IGG L CHAIN (Homo sapiens)	4 / 8	ILE H 51 THR H 58 THR L 100 SER H 61	1.71A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6C06_D_FI8D1404_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6yor	IGG H CHAIN IGG L CHAIN (Homo sapiens)	4 / 8	THR H 0 GLN H 1 GLU L 61 SER L 62	1.17A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6C06_D_FI8D1404_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6yor	IGG H CHAIN IGG L CHAIN (Homo sapiens)	4 / 8	THR B 0 GLN B 1 GLU C 61 SER C 62	1.16A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6C06_D_FI8D1404_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6yor	IGG H CHAIN IGG L CHAIN (Homo sapiens)	4 / 8	ILE B 51 THR B 58 THR C 100 SER B 61	1.70A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6yor	IGG L CHAIN (Homo sapiens)	4 / 8	ILE L 123 VAL L 169 GLU L 167 SER L 165	1.68A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BZO_C_FI8C1201_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA)	6yor	IGG L CHAIN (Homo sapiens)	5 / 12	THR L 5 GLN L 6 THR L 108 VAL L 91 VAL L 110	1.45A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6yor	IGG H CHAIN IGG L CHAIN (Homo sapiens)	4 / 8	ILE L 123 VAL H 215 LYS H 214 SER H 183	1.66A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6yor	IGG H CHAIN IGG L CHAIN (Homo sapiens)	4 / 8	ILE C 123 VAL B 215 LYS B 214 SER B 183	1.66A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_1 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6yor	IGG H CHAIN IGG L CHAIN SPIKE GLYCOPROTEIN (Homo sapiens; SARS-CoV-2)	4 / 8	ASP E 389 GLU L 61 VAL H 108 GLN L 96	1.54A	10.07	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6yt8	REPLICASE POLYPROTEIN 1AB (SARS-CoV-2)	4 / 8	GLN A 19 THR A 26 VAL A 42 SER A 147	1.65A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6C06_D_FI8D1404_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6ywk	NSP3 MACRODOMAIN (SARS-CoV-2)	4 / 8	ILE B 106 THR B 146 GLU B 114 SER B 111	1.76A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6C06_D_FI8D1404_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6ywk	NSP3 MACRODOMAIN (SARS-CoV-2)	4 / 8	ILE C 106 THR C 146 GLU C 114 SER C 111	1.76A		EDO C 208 ( 4.2A) None None None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6C06_D_FI8D1404_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6ywk	NSP3 MACRODOMAIN (SARS-CoV-2)	4 / 8	ILE E 106 THR E 146 GLU E 114 SER E 111	1.71A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6C06_D_FI8D1404_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6ywl	NSP3 MACRODOMAIN (SARS-CoV-2)	4 / 8	ILE E 106 THR E 146 GLU E 114 SER E 111	1.74A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6C06_D_FI8D1404_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6ywl	NSP3 MACRODOMAIN (SARS-CoV-2)	4 / 8	ILE C 106 THR C 146 GLU C 114 SER C 111	1.79A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BZO_C_FI8C1201_2 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA RNA POLYMERASE SIGMA FACTOR SIGA)	6ywl	NSP3 MACRODOMAIN (SARS-CoV-2)	4 / 4	LEU A 108 ASP A 105 GLN A 107 VAL A 35	1.73A	15.12	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6C06_D_FI8D1404_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6ywl	NSP3 MACRODOMAIN (SARS-CoV-2)	4 / 8	ILE B 106 THR B 146 GLU B 114 SER B 111	1.62A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6ywm	NSP3 MACRODOMAIN (SARS-CoV-2)	4 / 8	MET A 2 THR A 33 VAL A 34 SER A 84	1.74A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	6ywm	NSP3 MACRODOMAIN (SARS-CoV-2)	4 / 8	ILE A 106 GLN A 107 VAL C 147 GLU A 114	1.76A		EDO A 205 ( 4.3A) EDO C 205 (-3.9A) None None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	7bqy	MAIN PROTEASE (SARS-CoV-2)	4 / 8	MET A 235 THR A 201 VAL A 204 SER A 267	1.74A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	7bqy	MAIN PROTEASE (SARS-CoV-2)	4 / 8	MET A 6 GLN A 127 THR A 111 GLU A 290	1.74A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	7bqy	MAIN PROTEASE (SARS-CoV-2)	4 / 8	GLN A 19 THR A 26 VAL A 42 SER A 147	1.60A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	7bqy	MAIN PROTEASE (SARS-CoV-2)	4 / 8	GLN A 19 THR A 26 VAL A 42 SER A 144	1.78A		None None None PJE C 5 ( 4.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_1 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	7btf	NSP12 (SARS-CoV-2)	5 / 8	ARG A 735 ARG A 305 GLU A 474 VAL A 476 ARG A 651	1.60A	21.10	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	7btf	NSP12 (SARS-CoV-2)	4 / 8	GLN A 789 THR A 701 VAL A 704 SER A 784	1.68A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	7btf	NSP12 (SARS-CoV-2)	4 / 8	GLN A 661 THR A 538 GLU A 665 SER A 664	1.11A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6C06_D_FI8D1404_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	7btf	NSP12 (SARS-CoV-2)	4 / 8	ILE A 536 THR A 538 GLN A 661 SER A 664	1.77A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	7btf	NSP12 (SARS-CoV-2)	4 / 8	GLN A 698 THR A 701 VAL A 704 SER A 784	1.68A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BZO_C_FI8C1201_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA)	7btf	NSP12 (SARS-CoV-2)	5 / 12	GLN A 661 THR A 538 GLU A 665 SER A 664 GLU A 350	1.68A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	7btf	NSP12 (SARS-CoV-2)	4 / 8	ILE A 466 GLN A 468 THR A 701 VAL A 700	1.55A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BZO_C_FI8C1201_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA)	7btf	NSP12 (SARS-CoV-2)	5 / 12	MET A 566 ILE A 562 THR A 565 GLU A 658 GLU A 665	1.72A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	7btf	NSP12 (SARS-CoV-2)	4 / 8	ILE A 244 THR A 319 VAL A 320 GLU A 254	1.44A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_1 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	7btf	NSP12 (SARS-CoV-2)	4 / 8	ASP A 258 ARG A 183 GLU A 254 GLN A 210	1.30A	21.10	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6C06_D_FI8D1404_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	7btf	NSP12 (SARS-CoV-2)	4 / 8	ILE A 562 THR A 565 THR A 531 ARG A 654	1.66A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_1 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	7btf	NSP7 NSP8 (SARS-CoV-2)	4 / 8	ASP B 163 GLU C 23 VAL C 33 GLN D 88	1.74A	9.27	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_1 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	7buy	VIRUS MAIN PROTEASE (SARS-CoV-2)	4 / 8	ASP A 187 ARG A 40 VAL A 171 GLN A 110	1.68A	13.60	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	7buy	VIRUS MAIN PROTEASE (SARS-CoV-2)	4 / 8	MET A 6 GLN A 127 THR A 111 GLU A 290	1.68A		DMS A 406 (-3.6A) DMS A 406 (-3.3A) None None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_1 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	7bv1	NSP7 NSP8 (SARS-CoV-2)	4 / 8	ASP B 163 GLU C 23 VAL C 33 GLN D 88	1.70A	9.19	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_1 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	7bv1	NSP12 (SARS-CoV-2)	4 / 8	ASP A 258 ARG A 183 GLU A 254 GLN A 210	1.36A	21.38	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	7bv1	NSP12 (SARS-CoV-2)	4 / 8	GLN A 789 THR A 701 VAL A 704 SER A 784	1.68A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6C06_D_FI8D1404_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	7bv1	NSP12 (SARS-CoV-2)	4 / 8	ILE A 488 GLN A 570 THR A 567 GLU A 658	1.70A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BZO_C_FI8C1201_2 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA RNA POLYMERASE SIGMA FACTOR SIGA)	7bv1	NSP7 NSP8 (SARS-CoV-2)	4 / 4	LEU C 35 ASP C 38 GLN C 34 VAL D 130	1.47A	10.52	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	7bv1	NSP12 (SARS-CoV-2)	4 / 8	ILE A 466 GLN A 468 THR A 701 VAL A 700	1.53A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6C06_D_FI8D1404_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	7bv1	NSP12 (SARS-CoV-2)	4 / 8	ILE A 488 GLN A 570 LYS A 369 GLU A 522	1.68A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	7bv1	NSP12 (SARS-CoV-2)	4 / 8	GLN A 661 THR A 538 GLU A 665 SER A 664	1.14A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_1 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	7bv1	NSP12 (SARS-CoV-2)	4 / 8	ASP A 235 ARG A 735 VAL A 128 GLN A 698	1.73A	21.38	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_1 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	7bv1	NSP12 (SARS-CoV-2)	5 / 8	ARG A 735 ARG A 305 GLU A 474 VAL A 476 ARG A 651	1.66A	21.38	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_1 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	7bv1	NSP12 (SARS-CoV-2)	4 / 8	ASP A 304 ARG A 640 GLU A 658 GLN A 492	1.69A	21.38	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6C06_D_FI8D1404_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	7bv1	NSP12 (SARS-CoV-2)	4 / 8	ILE A 562 THR A 565 THR A 531 ARG A 654	1.65A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	7bv1	NSP12 (SARS-CoV-2)	4 / 8	ILE A 244 THR A 319 VAL A 320 GLU A 254	1.52A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_1 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	7bv1	NSP12 (SARS-CoV-2)	4 / 8	ARG A 721 VAL A 204 ARG A 132 GLN A 468	1.71A	21.38	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	7bv1	NSP12 (SARS-CoV-2)	4 / 8	GLN A 698 THR A 701 VAL A 704 SER A 784	1.71A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	7bv2	NSP12 (SARS-CoV-2)	4 / 8	ILE A 244 THR A 319 VAL A 320 GLU A 254	1.37A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	7bv2	NSP12 (SARS-CoV-2)	4 / 8	GLN A 661 THR A 538 GLU A 665 SER A 664	1.08A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BZO_C_FI8C1201_2 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA RNA POLYMERASE SIGMA FACTOR SIGA)	7bv2	NSP12 (SARS-CoV-2)	4 / 4	LEU A 240 ASP A 465 GLN A 468 VAL A 31	1.63A	19.45	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_1 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	7bv2	NSP12 (SARS-CoV-2)	4 / 8	ASP A 235 ARG A 735 VAL A 128 GLN A 698	1.73A	21.38	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_1 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	7bv2	NSP12 (SARS-CoV-2)	4 / 8	ASP A 481 ARG A 640 VAL A 700 GLN A 292	1.68A	21.38	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	7bv2	NSP12 (SARS-CoV-2)	4 / 8	ILE A 466 GLN A 468 THR A 701 VAL A 700	1.43A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	7bv2	NSP12 (SARS-CoV-2)	4 / 8	GLN A 698 THR A 701 VAL A 704 SER A 784	1.75A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6C06_D_FI8D1404_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	7bv2	NSP12 (SARS-CoV-2)	4 / 8	ILE A 562 THR A 565 THR A 531 ARG A 654	1.63A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	7bv2	NSP12 (SARS-CoV-2)	4 / 8	MET A 755 ILE A 757 LYS A 807 SER A 814	1.53A		None None None U P 20 ( 2.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6C06_D_FI8D1404_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	7bv2	NSP12 (SARS-CoV-2)	4 / 8	ILE A 536 THR A 538 GLN A 661 SER A 664	1.70A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_0 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	7bv2	NSP12 (SARS-CoV-2)	4 / 8	GLN A 789 THR A 701 VAL A 704 SER A 784	1.63A		None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FBV_D_FI8D1904_1 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA')	7bv2	NSP12 (SARS-CoV-2)	5 / 8	ARG A 735 ARG A 305 GLU A 474 VAL A 476 ARG A 651	1.57A	21.38	None