Ligand ID: EXM


Drugbank ID:
DB00990
(Exemestane)


Indication:
For the treatment of advanced breast cancer in postmenopausal women whose disease has progressed following tamoxifen therapy.

Get human targets for EXM in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'EXM'

Click here for results that match SARS-Cov-2 / COVID-19 structures only
Click here for results that match SARS-related structures only


1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S7S_A_EXMA601_1
(CYTOCHROME P450 19A1)		5e6j REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 9
ARG A 285
ILE A 277
ALA A 279
THR A 282
LEU A 291
1.65A19.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S7S_A_EXMA601_1
(CYTOCHROME P450 19A1)		5tl6 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 9
ARG D 285
ILE D 277
ALA D 279
THR D 282
LEU D 291
1.69A19.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S7S_A_EXMA601_1
(CYTOCHROME P450 19A1)		6jyt HELICASE
(SARSr-CoV)		5 / 9
ILE B 376
ALA B 308
ASP B 374
THR B 307
VAL B 371
1.61A20.85
None