Ligand ID: CTX


Drugbank ID:
DB00675
(Tamoxifen)


Indication:
Tamoxifen is indicated for the treatment of metastatic breast cancer in women and men and ductal carcinoma in Situ.

Get human targets for CTX in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'CTX'

Click here for results that match SARS-Cov-2 / COVID-19 structures only
Click here for results that match SARS-related structures only


1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		1q2w 3C-LIKE PROTEASE
(SARSr-CoV)		6 / 12
PHE B 159
GLY B 146
VAL B  20
LEU B  86
LEU B  32
LEU B  89
1.72A20.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		1qz8 POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
ALA B  43
SER B  35
LEU B   9
MET B 101
LEU B   4
1.42A12.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		1ssk NUCLEOCAPSID PROTEIN
(SARSr-CoV)		4 / 4
LEU A  99
PRO A 120
ILE A  62
LEU A  91
1.67A16.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		1wof 3C-LIKE PROTEINASE
(SARSr-CoV)		6 / 12
PHE B 159
GLY B 146
VAL B  20
LEU B  86
LEU B  32
LEU B  89
1.67A20.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		1xak ORF7A ACCESSORY
PROTEIN
(SARSr-CoV)		4 / 4
LEU A  62
PRO A  33
ILE A  15
LEU A  16
1.27A9.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		1z1j 3C-LIKE PROTEINASE
(SARSr-CoV)		6 / 12
PHE A 159
GLY A 146
VAL A  20
LEU A  86
LEU A  32
LEU A  89
1.66A20.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		1zvb E2 GLYCOPROTEIN
(SARSr-CoV)		5 / 12
LEU B  24
SER B  25
LEU B  20
LEU B  27
LEU C  24
1.43A6.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		2acf REPLICASE
POLYPROTEIN 1AB
(SARS-COV
Tor2)		5 / 12
ALA C 220
GLY C 261
GLY C 260
SER C 321
LEU C 290
1.29A17.52
GOL  C1005 (-4.2A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		2acf REPLICASE
POLYPROTEIN 1AB
(SARS-COV
Tor2)		4 / 4
LEU C 351
PRO C 318
ILE C 200
LEU C 194
1.37A17.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		2ahm REPLICASE
POLYPROTEIN 1AB,
LIGHT CHAIN
(SARSr-CoV)		5 / 12
LEU A  64
LEU A  60
LEU A  25
MET A  67
LEU A  33
1.36A9.86
None
None
None
None
GOL  A2003 (-3.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		2ahm REPLICASE
POLYPROTEIN 1AB,
HEAVY CHAIN
REPLICASE
POLYPROTEIN 1AB,
LIGHT CHAIN
(SARSr-CoV)		4 / 4
LEU D  64
PRO H 126
ILE H 111
LEU D  61
1.36A9.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		2ahm REPLICASE
POLYPROTEIN 1AB,
HEAVY CHAIN
REPLICASE
POLYPROTEIN 1AB,
LIGHT CHAIN
(SARSr-CoV)		6 / 12
PHE H  97
VAL A  16
LEU A   3
SER A   9
LEU A  45
LEU H 100
1.68A17.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		2ajf ACE2
(Homo
sapiens)		4 / 4
LEU B 444
PRO B 415
ILE B 436
LEU B 591
1.57A21.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		2cjr NUCLEOCAPSID PROTEIN
(SARS-COV
TW1)		4 / 4
LEU D 354
PRO C 310
ILE D 338
LEU C 332
1.56A14.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		2cme HYPOTHETICAL PROTEIN
5
(SARSr-CoV)		4 / 4
LEU C  55
PRO D  89
ILE D  45
LEU D  22
1.42A9.25
None
None
D10  C1099 ( 4.7A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		2cme HYPOTHETICAL PROTEIN
5
(SARSr-CoV)		4 / 4
LEU B  22
PRO A  40
ILE B  20
LEU A  22
1.53A9.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		2cme HYPOTHETICAL PROTEIN
5
(SARSr-CoV)		4 / 4
LEU A  55
PRO B  89
ILE B  45
LEU B  22
1.52A9.21
D10  B1099 ( 4.2A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		2cme HYPOTHETICAL PROTEIN
5
(SARSr-CoV)		4 / 4
LEU G  55
PRO H  89
ILE H  45
LEU H  22
1.45A9.21
D10  H1099 ( 4.8A)
None
D10  H1099 ( 4.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		2d2d 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
PHE A 150
GLY A  11
GLY B  11
LEU B 115
SER B 147
1.43A20.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		2duc REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		6 / 12
GLY B  23
VAL B  20
SER B  62
LEU B  67
LEU B  57
LEU B  89
1.49A20.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		2fav REPLICASE
POLYPROTEIN 1AB
(PP1AB) (ORF1AB)
(SARSr-CoV)		5 / 12
ALA A  39
GLY A  80
GLY A  79
SER A 140
LEU A 109
1.24A17.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		2fe8 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 8
PRO A  34
LEU A  59
LEU B  76
PRO B  60
1.24A20.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		2fe8 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 7
PRO A  34
LEU A  59
LEU B  76
PRO B  60
1.30A20.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		2ghw ANTI-SCFV ANTIBODY,
80R
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARSr-CoV)		4 / 8
PRO C 462
GLY D 196
LEU C 443
PRO C 469
1.40A16.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		2ghw ANTI-SCFV ANTIBODY,
80R
(Homo
sapiens)		5 / 12
ALA B 157
GLY B 231
SER B 224
LEU B 165
LEU B 104
1.36A17.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		2ghw ANTI-SCFV ANTIBODY,
80R
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARSr-CoV)		4 / 7
PRO C 462
GLY D 196
LEU C 443
PRO C 469
1.41A16.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		2gib NUCLEOCAPSID PROTEIN
(SARSr-CoV)		4 / 4
LEU A 354
PRO B 310
ILE A 338
LEU B 332
1.57A10.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		2gtb 3C-LIKE PROTEINASE
(SARSr-CoV)		6 / 12
PHE A 159
GLY A 146
VAL A  20
LEU A  86
LEU A  32
LEU A  89
1.69A20.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		2h85 PUTATIVE ORF1AB
POLYPROTEIN
(SARSr-CoV)		4 / 7
PRO A  67
LEU A 122
GLY A 140
LEU A  72
1.53A22.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		2liz 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 7
PRO A 293
LEU A 250
GLY A 251
LEU A 202
1.50A11.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		2ofz NUCLEOCAPSID PROTEIN
(SARS-COV
Tor2)		4 / 8
LEU A 162
GLY A  72
LEU A  57
PRO A 169
1.26A13.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		2op9 REPLICASE
POLYPROTEIN 1AB
(PP1AB, ORF1AB)
3C-LIKE PROTEINASE
(3CL-PRO, 3CLP)
(SARSr-CoV)		6 / 12
PHE B 159
GLY B 146
VAL B  20
LEU B  86
LEU B  32
LEU B  89
1.65A20.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		4 / 7
PRO D  67
LEU D 122
GLY D 140
LEU D  72
1.49A22.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 12
GLY D 238
LEU D 254
LEU D 250
LEU D 263
LEU D 214
1.44A22.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		4 / 8
PRO D  67
LEU D 122
GLY D 140
LEU D  72
1.47A22.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		2q6g REPLICASE
POLYPROTEIN 1AB
(SARS-COV
BJ01)		6 / 12
PHE A 159
GLY A 146
VAL A  20
LEU A  86
LEU A  32
LEU A  89
1.65A20.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		2qiq REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		6 / 12
PHE A 159
GLY A 146
VAL A  20
LEU A  86
LEU A  32
LEU A  89
1.65A21.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		4 / 7
PRO E  67
LEU E 122
GLY E 140
LEU E  72
1.50A22.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		2rnk REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 4
LEU A 546
PRO A 607
ILE A 592
LEU A 596
1.57A12.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		2vj1 MAIN PROTEINASE
(SARSr-CoV)		6 / 12
PHE A 159
GLY A 146
VAL A  20
LEU A  86
LEU A  32
LEU A  89
1.63A20.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		2wct NSP3
(SARSr-CoV)		5 / 12
ALA B 500
SER B 425
LEU B 471
SER B 472
LEU B 504
1.39A18.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		2wct NSP3
(SARSr-CoV)		4 / 4
LEU C 421
PRO C 479
ILE C 454
LEU C 413
1.56A18.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		2xyq PUTATIVE 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		4 / 4
LEU A 212
PRO A  62
ILE A 282
LEU A 163
1.59A20.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		2xyv PUTATIVE 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		4 / 4
LEU A 212
PRO A  62
ILE A 282
LEU A 163
1.58A20.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		3bgf F26G19 FAB
(Mus
musculus)		5 / 12
SER H 204
SER H 113
LEU H 176
LEU H  11
HIS H 201
1.37A18.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		3d0h ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 12
ALA B 311
GLY B 377
GLY B 405
SER B 545
LEU B 529
1.36A22.22
None
None
None
NDG  B 618 ( 4.8A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		3d0i ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 4
LEU B 444
PRO B 415
ILE B 436
LEU B 591
1.54A22.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		3d0i ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 7
LEU B 554
GLY B 551
LEU B 558
PRO B 321
1.22A22.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		3d0i ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 8
LEU B 554
GLY B 551
LEU B 558
PRO B 321
1.18A22.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		3ea8 3C-LIKE PROTEINASE
(SARSr-CoV)		6 / 12
PHE A 159
GLY A 146
VAL A  20
LEU A  86
LEU A  32
LEU A  89
1.66A21.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		3ea9 3C-LIKE PROTEINASE
(SARSr-CoV)		6 / 12
PHE A 159
GLY A 146
VAL A  20
LEU A  86
LEU A  32
LEU A  89
1.69A21.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		3eaj 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 4
LEU B 242
PRO A 184
ILE B 249
LEU B 250
1.59A21.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		3ee7 REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		4 / 7
PRO D   6
LEU D  97
GLY D 100
LEU C 103
1.53A12.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		3ee7 REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		5 / 12
ALA A 107
GLY A 100
LEU B  97
LEU B   9
LEU B  94
1.39A12.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		3f9h 3C-LIKE PROTEINASE
(SARSr-CoV)		6 / 12
PHE A 159
GLY A 146
VAL A  20
LEU A  86
LEU A  32
LEU A  89
1.70A19.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		3i6g HLA, A-2
MEMBRANE PROTEIN
(Homo
sapiens)		5 / 12
PHE A  22
LEU C   1
MET C   2
LEU A 156
HIS A  74
1.36A18.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		3i6k HLA, A-2
MEMBRANE
GLYCOPROTEIN PEPTIDE
(Homo
sapiens;
SARS-COV
TJF)		6 / 12
ALA C   2
PHE A   8
GLY A 100
GLY A 112
LEU A 156
LEU A 130
1.73A3.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		3iwm 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
PHE D 181
GLY D 179
SER D 158
LEU D  30
HIS D 164
1.36A20.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		3m3s 3C-LIKE PROTEINASE
(SARSr-CoV)		6 / 12
PHE A 159
GLY A 146
VAL A  20
LEU A  86
LEU A  32
LEU A  89
1.69A20.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		3mj5 REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		5 / 12
ALA A  87
PHE A  57
GLY A  82
SER A 156
LEU A 151
1.38A20.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		3r24 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		4 / 4
LEU A 212
PRO A  62
ILE A 282
LEU A 163
1.60A21.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		3scj ACE2
(Homo
sapiens)		4 / 8
LEU A 554
GLY A 551
LEU A 558
PRO A 321
1.22A21.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		3scj ACE2
(Homo
sapiens)		4 / 4
LEU B 444
PRO B 415
ILE B 436
LEU B 591
1.62A21.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		3scj ACE2
(Homo
sapiens)		4 / 7
LEU A 554
GLY A 551
LEU A 558
PRO A 321
1.29A21.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		3sck ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 8
MET B 376
GLY B 551
LEU B 558
PRO B 321
1.25A21.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC1383_1
(CES1 PROTEIN)		3sck SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 5
TRP F 476
PRO F 477
GLY F 480
LYS F 439
1.74A16.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		3sck ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 4
LEU B 444
PRO B 415
ILE B 436
LEU B 591
1.55A21.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		3sck ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 12
ALA B 311
GLY B 377
GLY B 405
SER B 545
LEU B 529
1.32A21.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		3sck ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 7
LEU B 554
GLY B 551
LEU B 558
PRO B 321
1.33A21.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		4hi3 3C-LIKE PROTEINASE
(SARSr-CoV)		6 / 12
PHE A 159
GLY A 146
VAL A  20
LEU A  86
LEU A  32
LEU A  89
1.68A20.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		4m0w REPLICASE
POLYPROTEIN 1A
UBIQUITIN
(Bos
taurus;
SARSr-CoV)		4 / 7
PRO A 248
LEU B   8
GLY B  10
LYS B   6
1.29A20.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		4m0w REPLICASE
POLYPROTEIN 1A
UBIQUITIN
(Bos
taurus;
SARSr-CoV)		4 / 8
PRO A 248
LEU B   8
GLY B  10
LYS B   6
1.14A20.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC1383_1
(CES1 PROTEIN)		4m0w REPLICASE
POLYPROTEIN 1A
UBIQUITIN
(Bos
taurus;
SARSr-CoV)		4 / 5
PRO A 248
LEU B   8
GLY B  10
LYS B   6
1.23A20.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		4mds 3C-LIKE PROTEINASE
(SARSr-CoV)		6 / 12
PHE A 159
GLY A 146
VAL A  20
LEU A  86
LEU A  32
LEU A  89
1.63A21.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		4mm3 PAPAIN-LIKE
PROTEINASE
UBIQUITIN
(Homo
sapiens;
SARSr-CoV)		4 / 8
PRO B 248
LEU A   8
GLY A  10
LYS A   6
1.19A20.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		4mm3 PAPAIN-LIKE
PROTEINASE
UBIQUITIN
(Homo
sapiens;
SARSr-CoV)		4 / 7
PRO B 248
LEU A   8
GLY A  10
LYS A   6
1.36A20.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC1383_1
(CES1 PROTEIN)		4mm3 PAPAIN-LIKE
PROTEINASE
UBIQUITIN
(Homo
sapiens;
SARSr-CoV)		4 / 5
PRO B 248
LEU A   8
GLY A  10
LYS A   6
1.31A20.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		4tww 3C-LIKE PROTEINASE
(SARSr-CoV)		6 / 12
PHE A 159
GLY A 146
VAL A  20
LEU A  86
LEU A  32
LEU A  89
1.56A21.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		5b6o 3C-LIKE PROTEINASE
(SARSr-CoV)		6 / 12
PHE A 159
GLY A 146
VAL A  20
LEU A  86
LEU A  32
LEU A  89
1.61A21.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		5c8s GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		5 / 12
ALA D 281
SER D 112
LEU D 411
LEU D 174
HIS D  82
1.30A20.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		5c8t GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		5 / 12
ALA D 281
SER D 112
LEU D 411
LEU D 174
HIS D  82
1.34A20.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		4 / 4
LEU B 107
PRO A 327
ILE B 150
LEU B 152
1.68A20.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		5 / 12
ALA B 281
SER B 112
LEU B 411
LEU B 174
HIS B  82
1.44A20.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
GLY A 258
SER A 254
VAL A 212
LEU A 262
LEU A 220
1.75A14.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
PHE A 159
GLY A  29
VAL A  68
SER A  81
LEU A  32
1.62A14.07
None
None
None
K1Y  A 404 (-3.2A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
LEU A 271
SER A 267
LEU A 272
LEU A 282
LEU A 205
1.74A14.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
PHE A 159
GLY A 146
VAL A  20
LEU A  27
LEU A  32
1.73A14.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
GLY A  23
SER A  62
LEU A  67
LEU A  57
LEU A  89
1.53A14.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
GLY A  23
VAL A  20
SER A  62
LEU A  57
LEU A  89
1.39A14.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
PHE A 159
GLY A  29
VAL A  68
SER A  81
LEU A  32
1.67A14.07
None
None
None
K1Y  A 404 (-3.2A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
LEU A 268
SER A 267
LEU A 272
LEU A 250
HIS A 246
1.65A14.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
LEU A 271
SER A 267
LEU A 272
LEU A 282
LEU A 205
1.76A14.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
GLY A  23
VAL A  20
SER A  62
LEU A  57
LEU A  89
1.40A14.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
LEU A 268
SER A 267
LEU A 272
LEU A 250
HIS A 246
1.70A14.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
VAL A  20
LEU A  87
LEU A  89
LEU A  57
LEU A  27
1.73A14.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
VAL A  20
LEU A  87
LEU A  89
LEU A  57
LEU A  27
1.78A14.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
PHE A 159
GLY A 146
VAL A  20
LEU A  27
LEU A  32
1.73A14.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
GLY A  23
SER A  62
LEU A  67
LEU A  57
LEU A  89
1.56A14.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
PHE A 140
GLY A 146
VAL A  13
LEU A 177
LEU A  30
1.64A14.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
PHE A 140
GLY A 146
VAL A  13
LEU A 177
LEU A  30
1.66A14.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
PHE A 159
GLY A  29
VAL A  68
LEU A  32
LEU A  75
1.79A14.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		5tl6 UBIQUITIN-LIKE
PROTEIN ISG15
(Homo
sapiens)		5 / 12
GLY C 138
LEU C  82
SER C  83
LEU C 142
LEU C 107
1.42A10.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		5tl7 UBIQUITIN-LIKE
PROTEIN ISG15
(Mus
musculus)		5 / 12
GLY A 136
LEU A  80
SER A  81
LEU A 140
LEU A 105
1.44A10.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		5tl7 REPLICASE
POLYPROTEIN 1AB
UBIQUITIN-LIKE
PROTEIN ISG15
(Mus
musculus;
SARSr-CoV)		5 / 12
ALA D 205
GLY C 126
SER C 123
MET D 244
HIS C 149
1.22A20.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		5wrg SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
ALA B 633
GLY B 579
GLY B 580
LEU B 597
LEU B 286
1.41A19.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		5x4r S PROTEIN
(MERS-CoV)		4 / 7
LEU A 265
GLY A 255
LEU A 171
PRO A 145
1.46A19.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		5x4r S PROTEIN
(MERS-CoV)		5 / 12
PHE A 116
SER A 294
LEU A 172
LEU A 171
LEU A 187
1.43A19.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		5x59 S PROTEIN
(MERS-CoV)		4 / 4
LEU B 414
PRO B 394
ILE B 491
LEU B 389
1.44A16.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		5x59 S PROTEIN
(MERS-CoV)		4 / 8
PRO B 739
LEU B 715
GLY B 675
LEU B 735
1.41A16.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		5x59 S PROTEIN
(MERS-CoV)		4 / 7
PRO B 739
LEU B 715
GLY B 675
LEU B 735
1.44A16.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 12
PHE B 325
GLY B 512
LEU B 377
SER C 964
LEU B 374
1.37A18.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		4 / 8
MET C 417
LEU C 412
GLY C 400
LYS C 411
1.43A18.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		5x5f S PROTEIN
(MERS-CoV)		5 / 12
PHE B 116
SER B 294
LEU B 172
LEU B 171
LEU B 187
1.43A16.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 8
PRO B  43
LEU B 264
LEU B  58
PRO B 218
1.43A19.10
PRO  B  43 ( 1.1A)
LEU  B 264 ( 0.6A)
LEU  B  58 ( 0.6A)
PRO  B 218 ( 1.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 7
PRO A  43
LEU A 264
LEU A  58
PRO A 218
1.47A19.10
PRO  A  43 ( 1.1A)
LEU  A 264 ( 0.6A)
LEU  A  58 ( 0.6A)
PRO  A 218 ( 1.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		6acg SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
ALA B 732
GLY B 739
SER C 950
LEU B 983
LEU B 734
1.37A19.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		6acj SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 4
LEU C 681
PRO B 844
ILE B 852
LEU B 847
1.60A19.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		6acj ACE2
(Homo
sapiens)		5 / 12
PHE D 230
GLY D 448
LEU D 240
LEU D 444
LEU D 262
1.37A21.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		6crw SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 8
MET A 722
LEU A 840
GLY A 820
PRO C 575
1.37A18.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		6crx SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
ALA C 732
GLY C 739
SER B 950
LEU C 983
LEU C 734
1.35A18.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		6cs2 ACE2
(Homo
sapiens)		4 / 7
LEU D 554
GLY D 551
LEU D 558
PRO D 321
1.27A22.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		6cs2 ACE2
(Homo
sapiens)		4 / 8
LEU D 554
GLY D 551
LEU D 558
PRO D 321
1.20A22.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		6cs2 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 7
GLY A 751
LYS A 715
LEU A 843
PRO C 651
1.45A18.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		6kl2 NUCLEOPROTEIN
(MERS-CoV)		4 / 8
GLY D 119
LYS D 117
LEU D 111
PRO D 107
1.50A14.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		6lxt SPIKE PROTEIN S2
(SARS-CoV-2)		5 / 12
ALA C1190
SER B 937
SER C 943
LEU C1186
LEU B 945
1.30A14.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		6lze VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
GLY A  23
VAL A  20
SER A  62
LEU A  57
LEU A  89
1.32A19.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		6lze VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
GLY A  23
VAL A  20
SER A  62
LEU A  57
LEU A  89
1.32A19.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		6lze VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
GLY A  23
SER A  62
LEU A  67
LEU A  57
LEU A  89
1.51A19.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
GLY A  23
VAL A  20
SER A  62
LEU A  57
LEU A  89
1.37A19.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
GLY A  23
VAL A  20
SER A  62
LEU A  57
LEU A  89
1.30A19.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		6m17 SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		4 / 7
LEU C 127
GLY C 126
LEU C 485
PRO C 593
1.21A20.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		6m17 SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 12
GLY A  51
SER A 431
SER A 307
LEU A  46
LEU A 286
1.38A20.86
None
LEU  A 707 (-4.2A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		6m17 ACE2
(Homo
sapiens)		4 / 7
LEU D 554
GLY D 551
LEU D 558
PRO D 321
1.27A21.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		6m17 ACE2
(Homo
sapiens)		4 / 8
LEU B 554
GLY B 551
LEU B 558
PRO B 321
1.22A21.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		6m17 SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		4 / 8
LEU C 127
GLY C 126
LEU C 485
PRO C 593
1.19A20.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		6m18 SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		6 / 12
PHE A 467
SER A 134
SER A 477
LEU A 482
LEU A 198
LEU A 181
1.53A20.86
3PH  A 707 ( 3.9A)
None
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
GLY A  23
VAL A  20
SER A  62
LEU A  57
LEU A  89
1.38A19.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
GLY C  23
VAL C  20
SER C  62
LEU C  57
LEU C  89
1.34A19.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
GLY C  23
VAL C  20
SER C  62
LEU C  57
LEU C  89
1.42A19.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
GLY B  23
VAL B  20
SER B  62
LEU B  57
LEU B  89
1.35A19.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		6m2n 3CL PROTEASE
(SARS-CoV-2)		6 / 12
GLY D  23
VAL D  20
SER D  62
LEU D  67
LEU D  57
LEU D  89
1.45A19.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
GLY B  23
VAL B  20
SER B  62
LEU B  57
LEU B  89
1.45A19.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
GLY D  23
SER D  62
LEU D  67
LEU D  57
LEU D  89
1.36A19.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
GLY D  23
VAL D  20
SER D  62
LEU D  57
LEU D  89
1.38A19.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
GLY A  23
VAL A  20
SER A  62
LEU A  57
LEU A  89
1.48A19.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		6m2q 3CL PROTEASE
(SARS-CoV-2)		5 / 12
GLY A  23
VAL A  20
SER A  62
LEU A  57
LEU A  89
1.41A19.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		6m2q 3CL PROTEASE
(SARS-CoV-2)		5 / 12
GLY A  23
VAL A  20
SER A  62
LEU A  57
LEU A  89
1.42A19.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		6m2q 3CL PROTEASE
(SARS-CoV-2)		5 / 12
GLY A  23
SER A  62
LEU A  67
LEU A  57
LEU A  89
1.53A19.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		6m3m NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 8
LEU C 162
GLY C 165
LEU C 168
PRO B 163
1.29A14.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		6m3m NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 7
LEU C 162
GLY C 165
LEU C 168
PRO B 163
1.27A14.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_2
(CES1 PROTEIN)		6m71 NSP7
NSP8
(SARS-CoV-2)		4 / 4
LEU C  59
PRO D 121
ILE D 106
LEU C  56
1.39A9.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		6m71 NSP12
(SARS-CoV-2)		4 / 4
LEU A 469
PRO A 461
ILE A 632
LEU A 630
1.68A18.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		6m71 NSP12
NSP8
(SARS-CoV-2)		6 / 12
PHE A 407
GLY A 670
GLY A 671
LEU A 388
LEU A 401
MET B 129
1.59A18.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_2
(CES1 PROTEIN)		6m71 NSP12
(SARS-CoV-2)		4 / 4
LEU A 470
PRO A 296
ILE A 307
LEU A 308
1.66A18.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		6m71 NSP12
(SARS-CoV-2)		4 / 4
LEU A 470
PRO A 296
ILE A 307
LEU A 308
1.56A18.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		6m71 NSP12
NSP8
(SARS-CoV-2)		4 / 8
PRO A 378
MET A 380
LEU A 673
PRO B 121
1.30A18.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		6m71 NSP12
NSP8
(SARS-CoV-2)		6 / 12
PHE A 407
GLY A 670
GLY A 671
LEU A 388
LEU A 673
MET B 129
1.72A18.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		6m71 NSP7
NSP8
(SARS-CoV-2)		5 / 12
SER C  15
SER C  54
LEU C  59
MET C  52
LEU D  95
1.50A9.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		6m71 NSP12
NSP8
(SARS-CoV-2)		5 / 12
ALA A 375
SER A 363
LEU B  91
LEU B  95
LEU A 371
1.50A18.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		6m71 NSP12
(SARS-CoV-2)		5 / 12
PHE A 368
VAL A 495
SER A 501
LEU A 498
LEU A 372
1.48A18.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_2
(CES1 PROTEIN)		6m71 NSP12
(SARS-CoV-2)		4 / 4
LEU A 883
PRO A 868
ILE A 837
LEU A 838
1.78A18.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		6m71 NSP12
NSP8
(SARS-CoV-2)		6 / 12
PHE A 407
GLY A 670
GLY A 671
LEU A 388
LEU A 401
MET B 129
1.56A18.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		6m71 NSP12
(SARS-CoV-2)		4 / 8
PRO A 243
MET A 242
GLY A 179
LEU A 131
1.60A18.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		6m71 NSP12
(SARS-CoV-2)		4 / 8
PRO A 243
MET A 242
LEU A 247
LEU A 131
1.75A18.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		6m71 NSP12
NSP7
NSP8
(SARS-CoV-2)		5 / 12
PHE A 440
LEU C  55
SER C  54
MET C  52
LEU D  95
1.49A18.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		6m71 NSP12
NSP8
(SARS-CoV-2)		4 / 8
MET A 380
LEU A 401
LEU A 673
PRO B 121
1.15A18.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		6m71 NSP7
NSP8
(SARS-CoV-2)		6 / 12
PHE D  92
VAL C  22
LEU C  55
LEU C  14
LEU C  60
LEU C  28
1.68A18.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		6m71 NSP12
NSP7
NSP8
(SARS-CoV-2)		5 / 12
PHE A 440
LEU C  55
SER C  54
MET C  52
LEU D  95
1.41A18.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		6m71 NSP8
(SARS-CoV-2)		5 / 12
GLY B 144
VAL B 159
SER B 173
LEU B 169
LEU B 184
1.32A18.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		6m71 NSP12
NSP7
(SARS-CoV-2)		5 / 12
GLY A 841
GLY A 839
LEU A 437
SER C   4
LEU C  40
1.36A18.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		6m71 NSP8
(SARS-CoV-2)		4 / 4
LEU B  98
PRO B 116
ILE B 107
LEU B 103
1.70A18.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		6m71 NSP8
(SARS-CoV-2)		5 / 12
GLY B 144
VAL B 159
SER B 173
LEU B 169
LEU B 184
1.44A18.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		6m71 NSP7
NSP8
(SARS-CoV-2)		5 / 12
LEU C  55
SER C  54
LEU C  59
MET C  52
LEU D  95
1.50A9.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		6m71 NSP7
NSP8
(SARS-CoV-2)		5 / 12
LEU C  55
SER C  54
LEU C  17
LEU D  98
LEU C  60
1.23A9.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		6m71 NSP7
NSP8
(SARS-CoV-2)		5 / 12
LEU C  55
SER C  10
LEU C  56
LEU C  14
LEU D  91
1.53A9.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		6m71 NSP7
NSP8
(SARS-CoV-2)		5 / 12
LEU C  55
SER C  54
LEU C  59
MET C  52
LEU D  95
1.45A9.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		6m71 NSP12
NSP7
(SARS-CoV-2)		5 / 12
GLY A 841
GLY A 839
LEU A 437
SER C   4
LEU C  40
1.25A18.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_2
(CES1 PROTEIN)		6m71 NSP8
(SARS-CoV-2)		4 / 4
LEU B  98
PRO B 116
ILE B 107
LEU B 103
1.72A18.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		6m71 NSP12
NSP7
NSP8
(SARS-CoV-2)		5 / 12
ALA A 443
LEU C  14
SER C  10
LEU C  17
LEU D  91
1.39A18.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		6m71 NSP7
NSP8
(SARS-CoV-2)		5 / 12
LEU C  55
SER C  54
LEU C  17
LEU D  98
LEU C  60
1.16A9.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		6m71 NSP12
NSP7
(SARS-CoV-2)		6 / 12
ALA A 423
GLY A 841
GLY A 839
LEU A 437
SER C   4
LEU C  40
1.43A18.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		6m71 NSP7
NSP8
(SARS-CoV-2)		5 / 12
LEU C  55
SER C  54
LEU C  59
MET C  52
LEU D  95
1.35A9.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		6m71 NSP12
NSP8
(SARS-CoV-2)		6 / 12
PHE A 407
GLY A 670
GLY A 671
LEU A 388
LEU A 401
MET B 129
1.61A18.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		6m71 NSP12
NSP7
(SARS-CoV-2)		5 / 12
ALA A 443
SER C  25
LEU C  14
SER C  15
LEU C  20
1.52A18.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		6m71 NSP7
NSP8
(SARS-CoV-2)		4 / 4
LEU C  59
PRO D 121
ILE D 106
LEU C  56
1.31A9.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_2
(CES1 PROTEIN)		6m71 NSP12
(SARS-CoV-2)		4 / 4
LEU A 469
PRO A 461
ILE A 632
LEU A 630
1.58A18.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		6m71 NSP12
(SARS-CoV-2)		4 / 4
LEU A 883
PRO A 868
ILE A 837
LEU A 838
1.72A18.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		6m71 NSP7
NSP8
(SARS-CoV-2)		6 / 12
PHE D  92
VAL C  22
LEU C  55
LEU C  14
LEU C  60
LEU C  28
1.66A18.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 8
MET C 722
LEU C 840
GLY C 820
PRO A 575
1.16A18.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 4
LEU A 519
PRO A 309
ILE A 573
LEU A 538
1.43A18.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		6nb8 S230 ANTIGEN-BINDING
(FAB) FRAGMENT,
HEAVY CHAIN
(Homo
sapiens)		5 / 12
ALA H 151
GLY H 148
GLY H 147
SER H 141
LEU H 203
1.44A17.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		6nb8 S230 ANTIGEN-BINDING
(FAB) FRAGMENT,
LIGHT CHAIN
(Homo
sapiens)		4 / 4
LEU L  52
PRO L  18
ILE L  21
LEU L  78
1.49A19.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		6nur NSP7
NSP8
(SARSr-CoV)		4 / 4
LEU C  59
PRO D 121
ILE D 106
LEU C  56
1.45A9.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		6nur NSP7
NSP8
(SARSr-CoV)		6 / 12
PHE D  92
VAL C  22
LEU C  55
LEU C  14
LEU C  60
LEU C  28
1.53A17.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		6nur NSP12
NSP8
(SARSr-CoV)		6 / 12
PHE A 407
GLY A 670
GLY A 671
LEU A 388
LEU A 401
MET B 129
1.72A18.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		6nur NSP7
NSP8
(SARSr-CoV)		6 / 12
LEU C  55
SER C  54
LEU C  59
LEU C  40
MET C  52
LEU D  95
1.67A9.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		6nur NSP12
NSP7
(SARSr-CoV)		5 / 12
ALA A 423
GLY A 841
GLY A 839
SER C   4
LEU C  40
1.29A18.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		6nus NSP8
(SARSr-CoV)		4 / 4
LEU B  98
PRO B 116
ILE B 107
LEU B 103
1.63A17.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		6nus NSP12
NSP8
(SARSr-CoV)		4 / 8
MET A 380
LEU A 401
LEU A 673
PRO B 121
1.18A18.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		6nus NSP12
(SARSr-CoV)		4 / 4
LEU A 470
PRO A 296
ILE A 307
LEU A 308
1.49A18.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 4
LEU C 387
PRO C 412
ILE C 434
LEU C 513
1.67A17.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 7
PRO B 807
LEU B 878
GLY B 880
LEU B 806
1.43A17.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		6vw1 ACE2
(Homo
sapiens)		4 / 7
LEU A 554
GLY A 551
LEU A 558
PRO A 321
1.27A21.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		6vw1 ACE2
(Homo
sapiens)		4 / 8
LEU A 554
GLY A 551
LEU A 558
PRO A 321
1.24A21.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		6vxs NSP3
(SARS-CoV-2)		5 / 12
ALA A  27
GLY A  85
LEU A  88
LEU A  53
HIS A  94
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		6vxs NSP3
(SARS-CoV-2)		4 / 7
PRO A 125
GLY A  85
LEU A  53
PRO A  32
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		6vxs NSP3
(SARS-CoV-2)		4 / 8
PRO A 125
GLY A  85
LEU A  53
PRO A  32
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		6vxs NSP3
(SARS-CoV-2)		4 / 7
PRO B 125
GLY B  85
LEU B  53
PRO B  32
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		6vxs NSP3
(SARS-CoV-2)		4 / 8
PRO B 125
GLY B  85
LEU B  53
PRO B  32
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 4
LEU B 533
PRO B 521
ILE B 584
LEU B 585
1.71A17.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 7
PRO A 807
LEU A 878
GLY A 880
LEU A 806
1.43A17.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 4
LEU C 533
PRO C 521
ILE C 584
LEU C 585
1.67A17.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 8
PRO C 521
LEU C 518
GLY C 545
PRO C 330
1.45A17.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 7
PRO A 807
LEU A 878
GLY A 880
LEU A 806
1.42A17.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
PHE B  92
GLY B 103
LEU B 117
LEU B 118
LEU B 110
1.44A17.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		6vyo NUCLEOPROTEIN
(SARS-CoV-2)		4 / 8
LEU C 161
GLY C  71
LEU C  56
PRO C 168
1.26A13.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		6w02 NSP3
(SARS-CoV-2)		5 / 12
ALA A  38
GLY A  79
GLY A  78
SER A 139
LEU A 108
1.28A15.98
APR  A 201 (-3.4A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		6w41 CR3022 FAB HEAVY
CHAIN
(Homo
sapiens)		4 / 7
PRO H 126
LEU H 189
GLY H 190
LEU H 138
1.71A14.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		6w41 CR3022 FAB HEAVY
CHAIN
(Homo
sapiens)		5 / 12
ALA H 136
GLY H 134
GLY H 133
SER H 128
LEU H 189
1.72A14.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		6w41 CR3022 FAB HEAVY
CHAIN
(Homo
sapiens)		5 / 12
GLY H 106
GLY H 104
VAL H 102
LEU H   4
LEU H  45
1.74A14.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		6w41 CR3022 FAB HEAVY
CHAIN
(Homo
sapiens)		4 / 8
PRO H 126
LEU H 189
GLY H 190
LEU H 138
1.65A14.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 8
TRP H 103
MET H 100
LEU H   4
PRO L  43
1.77A14.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		5 / 12
PHE C 429
GLY C 381
LEU C 387
LEU C 390
LEU C 513
1.77A14.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 8
PRO H 213
LEU H 138
GLY H 139
PRO L 119
1.56A14.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 8
PRO L 119
LEU H 124
GLY H 139
PRO H 213
1.66A15.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		6w41 CR3022 FAB HEAVY
CHAIN
(Homo
sapiens)		5 / 12
GLY H 106
GLY H 104
VAL H 102
LEU H   4
LEU H  45
1.77A14.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 7
PRO L 119
LEU H 124
GLY H 139
PRO H 213
1.64A15.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 7
PRO H 213
LEU H 138
GLY H 139
PRO L 119
1.63A14.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		6w4b NSP9
(SARS-CoV-2)		5 / 12
ALA B  44
LEU B 107
SER B 106
LEU B 113
LEU A  10
1.41A12.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		6w4h NSP16
(SARS-CoV-2)		4 / 4
LEU A7010
PRO A6860
ILE A7080
LEU A6961
1.63A19.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
GLY A6963
GLY A6962
VAL A7057
LEU A7078
LEU A7050
1.67A16.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 4
LEU A7010
PRO A6860
ILE A7080
LEU A6961
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
GLY A6963
GLY A6962
LEU A7010
LEU A7073
LEU A6855
1.67A16.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
TRP A7029
PRO A6810
MET A6809
LEU A6812
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
GLY A6962
GLY A6963
VAL A6965
LEU A6857
LEU A6924
1.76A16.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
GLY A6963
GLY A6962
LEU A6961
LEU A7073
LEU A6981
1.71A16.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
GLY A6963
GLY A6962
LEU A7010
LEU A7073
LEU A6855
1.67A16.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
GLY A6890
VAL A6865
LEU A6893
LEU A7052
LEU A6924
1.63A16.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
GLY A6890
VAL A6865
LEU A6893
LEU A7052
LEU A6924
1.60A16.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
GLY A6963
GLY A6962
LEU A7073
SER A7071
LEU A7078
1.79A16.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_2
(CES1 PROTEIN)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 4
LEU A7010
PRO A6860
ILE A7080
LEU A6961
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
ALA A6986
GLY A6963
GLY A6962
SER A7071
LEU A6961
1.77A16.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
GLY A6962
GLY A6963
VAL A6865
LEU A6855
LEU A6887
1.77A16.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
GLY A6962
GLY A6963
VAL A6965
LEU A6857
LEU A6924
1.75A16.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
GLY A  23
VAL A  20
SER A  62
LEU A  57
LEU A  89
1.38A19.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
GLY A  23
VAL A  20
SER A  62
LEU A  57
LEU A  89
1.47A19.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		6w6y NSP3
(SARS-CoV-2)		5 / 12
SER B 139
VAL B 144
SER B 166
LEU B 160
LEU B  12
1.76A15.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		6w6y NSP3
(SARS-CoV-2)		5 / 12
PHE B 116
GLY B  78
VAL B  41
LEU B  93
LEU B  43
1.77A15.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		6w6y NSP3
(SARS-CoV-2)		5 / 12
VAL B  49
LEU B 127
SER B 128
LEU B  75
HIS B  94
1.35A
None
None
MES  B 201 ( 4.5A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		6w6y NSP3
(SARS-CoV-2)		5 / 12
GLY B  47
GLY B  51
VAL B  24
LEU B  43
LEU B  88
1.78A15.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		6w6y NSP3
(SARS-CoV-2)		5 / 12
SER A 139
VAL A 144
SER A 166
LEU A 160
LEU A  12
1.62A15.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		6w6y NSP3
(SARS-CoV-2)		5 / 12
PHE A 116
GLY A  78
VAL A  41
LEU A  93
LEU A  43
1.78A15.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		6w6y NSP3
(SARS-CoV-2)		4 / 7
PRO A 125
GLY A  85
LEU A  53
PRO A  32
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		6w6y NSP3
(SARS-CoV-2)		5 / 12
PHE A 116
GLY A  78
VAL A  41
LEU A  93
LEU A  43
1.74A15.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		6w6y NSP3
(SARS-CoV-2)		5 / 12
ALA B  38
GLY B  79
GLY B  78
LEU B 127
SER B 139
1.70A15.80
MES  B 201 ( 3.4A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		6w6y NSP3
(SARS-CoV-2)		5 / 12
SER B 139
VAL B 144
SER B 166
LEU B 160
LEU B  12
1.65A15.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		6w6y NSP3
(SARS-CoV-2)		5 / 12
ALA B  39
GLY B  79
GLY B  78
LEU B 108
LEU B 127
1.67A15.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		6w6y NSP3
(SARS-CoV-2)		4 / 8
PRO A 125
GLY A  85
LEU A  53
PRO A  32
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		6w6y NSP3
(SARS-CoV-2)		5 / 12
ALA B  27
GLY B  85
LEU B  88
LEU B  53
HIS B  94
1.69A15.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		6w6y NSP3
(SARS-CoV-2)		5 / 12
VAL A  49
LEU A 127
SER A 128
LEU A  75
HIS A  94
1.39A
AMP  A 201 ( 3.7A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		6w6y NSP3
(SARS-CoV-2)		4 / 7
PRO B 125
GLY B  85
LEU B  53
PRO B  32
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		6w6y NSP3
(SARS-CoV-2)		5 / 12
ALA A  39
GLY A  79
GLY A  78
LEU A 108
LEU A 127
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		6w6y NSP3
(SARS-CoV-2)		5 / 12
VAL A  49
LEU A 127
SER A 128
LEU A  75
HIS A  94
1.36A
AMP  A 201 ( 3.7A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		6w6y NSP3
(SARS-CoV-2)		5 / 12
GLY B   8
LEU A 169
SER A 166
LEU A  10
LEU A 140
1.76A15.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		6w6y NSP3
(SARS-CoV-2)		5 / 12
GLY B  47
GLY B  51
VAL B  24
LEU B  43
LEU B  88
1.78A15.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		6w6y NSP3
(SARS-CoV-2)		5 / 12
ALA B  38
GLY B  79
GLY B  78
SER B 139
LEU B 108
1.31A
MES  B 201 ( 3.4A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		6w6y NSP3
(SARS-CoV-2)		5 / 12
VAL B  49
LEU B 127
SER B 128
LEU B  75
HIS B  94
1.33A
None
None
MES  B 201 ( 4.5A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		6w6y NSP3
(SARS-CoV-2)		5 / 12
ALA A  38
GLY A  79
GLY A  78
LEU A 127
SER A 139
1.74A15.80
AMP  A 201 ( 3.9A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		6w6y NSP3
(SARS-CoV-2)		5 / 12
ALA A  27
GLY A  85
LEU A  88
LEU A  53
HIS A  94
1.66A15.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		6w6y NSP3
(SARS-CoV-2)		5 / 12
SER A 139
VAL A 144
SER A 166
LEU A 160
LEU A  12
1.73A15.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		6w6y NSP3
(SARS-CoV-2)		5 / 12
ALA B  38
GLY B  79
GLY B  78
LEU B 108
LEU B 127
1.75A15.80
MES  B 201 ( 3.4A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		6w6y NSP3
(SARS-CoV-2)		4 / 8
PRO B 125
GLY B  85
LEU B  53
PRO B  32
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		6w75 NSP16
(SARS-CoV-2)		5 / 12
GLY A6890
VAL A6865
LEU A6893
LEU A7052
LEU A6924
1.61A15.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		6w75 NSP16
(SARS-CoV-2)		4 / 4
LEU C7010
PRO C6860
ILE C7080
LEU C6961
1.63A15.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		6w75 NSP16
(SARS-CoV-2)		5 / 12
GLY C6963
GLY C6962
LEU C7010
LEU C7073
LEU C6855
1.68A15.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_2
(CES1 PROTEIN)		6w75 NSP16
(SARS-CoV-2)		4 / 4
LEU C7010
PRO C6860
ILE C7080
LEU C6961
1.60A15.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		6w75 NSP16
(SARS-CoV-2)		4 / 4
LEU A7010
PRO A6860
ILE A7080
LEU A6961
1.62A15.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		6w75 NSP16
(SARS-CoV-2)		5 / 12
GLY A6963
GLY A6962
LEU A6961
LEU A7073
LEU A6981
1.79A15.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		6w75 NSP16
(SARS-CoV-2)		5 / 12
GLY C6962
GLY C6963
VAL C6865
LEU C6855
LEU C6887
1.79A15.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		6w75 NSP16
(SARS-CoV-2)		5 / 12
GLY A6890
VAL A6865
LEU A6893
LEU A7052
LEU A6924
1.58A15.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		6w75 NSP16
(SARS-CoV-2)		5 / 12
GLY C6963
GLY C6962
LEU C7010
LEU C7073
LEU C6855
1.67A15.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_2
(CES1 PROTEIN)		6w75 NSP16
(SARS-CoV-2)		4 / 4
LEU C6857
PRO C6805
ILE C7005
LEU C6855
1.78A15.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		6w75 NSP16
(SARS-CoV-2)		5 / 12
GLY A6963
GLY A6962
LEU A7010
LEU A7073
LEU A6855
1.70A15.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		6w75 NSP16
(SARS-CoV-2)		5 / 12
GLY C6890
VAL C6865
LEU C6893
LEU C7052
LEU C6924
1.72A15.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		6w75 NSP16
(SARS-CoV-2)		5 / 12
GLY C6962
GLY C6963
VAL C6965
LEU C6857
LEU C6924
1.75A15.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		6w75 NSP16
(SARS-CoV-2)		5 / 12
GLY A6962
GLY A6963
VAL A6965
LEU A6857
LEU A6924
1.77A15.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		6w75 NSP16
(SARS-CoV-2)		4 / 8
MET A7068
LEU A7073
GLY A7076
LEU A7010
1.61A15.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		6w75 NSP16
(SARS-CoV-2)		5 / 12
GLY C6890
VAL C6865
LEU C6893
LEU C7052
LEU C6924
1.69A15.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		6w75 NSP16
(SARS-CoV-2)		5 / 12
GLY A6962
GLY A6963
VAL A6965
LEU A6857
LEU A6924
1.76A15.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		6w75 NSP16
(SARS-CoV-2)		5 / 12
GLY A6963
GLY A6962
LEU A7010
LEU A7073
LEU A6855
1.69A15.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		6w75 NSP16
(SARS-CoV-2)		5 / 12
GLY C6806
SER C7041
SER C6999
LEU C7037
LEU C6848
1.79A15.79
None
None
FMT  C7108 ( 2.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_2
(CES1 PROTEIN)		6w75 NSP16
(SARS-CoV-2)		4 / 4
LEU A7010
PRO A6860
ILE A7080
LEU A6961
1.59A15.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		6w75 NSP16
(SARS-CoV-2)		4 / 8
TRP C7029
PRO C6810
MET C6809
LEU C6812
1.75A15.79
None
FMT  C7109 ( 4.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		6w75 NSP16
(SARS-CoV-2)		5 / 12
GLY C6962
GLY C6963
VAL C6965
LEU C6857
LEU C6924
1.75A15.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		6w9q 3C-LIKE PROTEINASE
PEPTIDE, NSP9 FUSION
(SARS-CoV-2)		4 / 8
PRO A  72
LEU A  51
GLY A  17
LEU A  69
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		6w9q 3C-LIKE PROTEINASE
PEPTIDE, NSP9 FUSION
(SARS-CoV-2)		4 / 7
PRO A  72
LEU A  51
GLY A  17
LEU A  69
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		6wcf NSP3
(SARS-CoV-2)		5 / 12
VAL A  49
LEU A 127
SER A 128
LEU A  75
HIS A  94
1.37A
None
None
MES  A 201 (-4.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		6wcf NSP3
(SARS-CoV-2)		4 / 7
PRO A 125
GLY A  85
LEU A  53
PRO A  32
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		6wcf NSP3
(SARS-CoV-2)		5 / 12
VAL A  49
LEU A 127
SER A 128
LEU A  75
HIS A  94
1.38A
None
None
MES  A 201 (-4.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		6wcf NSP3
(SARS-CoV-2)		4 / 8
PRO A 125
GLY A  85
LEU A  53
PRO A  32
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		6wcf NSP3
(SARS-CoV-2)		5 / 12
ALA A  38
GLY A  79
GLY A  78
SER A 139
LEU A 108
1.24A
MES  A 201 (-3.6A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		6wen NSP3
(SARS-CoV-2)		4 / 8
PRO A 125
GLY A  85
LEU A  53
PRO A  32
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		6wen NSP3
(SARS-CoV-2)		5 / 12
VAL A  49
LEU A 127
SER A 128
LEU A  75
HIS A  94
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		6wen NSP3
(SARS-CoV-2)		5 / 12
VAL A  49
LEU A 127
SER A 128
LEU A  75
HIS A  94
1.46A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		6wen NSP3
(SARS-CoV-2)		4 / 7
PRO A 125
GLY A  85
LEU A  53
PRO A  32
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		6wen NSP3
(SARS-CoV-2)		5 / 12
ALA A  38
GLY A  79
GLY A  78
SER A 139
LEU A 108
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		6wen NSP3
(SARS-CoV-2)		5 / 12
ALA A  38
GLY A  79
GLY A  78
LEU A 108
LEU A 127
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		6wey NSP3
(SARS-CoV-2)		5 / 12
VAL A 253
LEU A 331
SER A 332
LEU A 279
HIS A 298
1.31A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		6wey NSP3
(SARS-CoV-2)		5 / 12
VAL A 253
LEU A 331
SER A 332
LEU A 279
HIS A 298
1.34A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		6wiq NSP7
NSP8
(SARS-CoV-2)		4 / 4
LEU A  59
PRO B 121
ILE B 106
LEU A  56
1.37A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_2
(CES1 PROTEIN)		6wiq NSP7
NSP8
(SARS-CoV-2)		4 / 4
LEU A  59
PRO B 121
ILE B 106
LEU A  56
1.47A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		6wiq NSP7
NSP8
(SARS-CoV-2)		5 / 12
PHE B  92
LEU A  55
LEU A  14
LEU A  60
LEU A  28
1.43A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		6wiq NSP7
NSP8
(SARS-CoV-2)		5 / 12
LEU A  55
SER A  54
LEU A  17
LEU B  98
LEU A  60
1.28A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		6wiq NSP7
NSP8
(SARS-CoV-2)		5 / 12
PHE B  92
VAL A  22
LEU A  55
LEU A  60
LEU A  28
1.24A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		6wiq NSP8
(SARS-CoV-2)		5 / 12
GLY B 144
VAL B 159
SER B 173
LEU B 169
LEU B 184
1.41A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		6wiq NSP8
(SARS-CoV-2)		5 / 12
GLY B 144
VAL B 159
SER B 173
LEU B 169
LEU B 184
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		6wiq NSP7
NSP8
(SARS-CoV-2)		5 / 12
PHE B  92
LEU A  55
LEU A  14
LEU A  60
LEU A  28
1.39A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		6wiq NSP7
NSP8
(SARS-CoV-2)		6 / 12
LEU A  55
SER A  54
LEU A  59
LEU A  40
MET A  52
LEU B  95
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		6wiq NSP7
NSP8
(SARS-CoV-2)		5 / 12
LEU A  55
SER A  10
LEU A  56
LEU A  14
LEU B  91
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		6wiq NSP7
NSP8
(SARS-CoV-2)		5 / 12
LEU A  55
SER A  54
LEU A  17
LEU B  98
LEU A  60
1.32A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		6wiq NSP7
NSP8
(SARS-CoV-2)		5 / 12
PHE B  92
VAL A  22
LEU A  55
LEU A  60
LEU A  28
1.26A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		6wiq NSP7
NSP8
(SARS-CoV-2)		5 / 12
LEU A  55
SER A  54
LEU A  59
MET A  52
LEU B  95
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 4
LEU A 339
PRO A 309
ILE B 320
LEU A 353
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_2
(CES1 PROTEIN)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 4
LEU A 353
PRO B 309
ILE A 337
LEU B 331
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_2
(CES1 PROTEIN)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 4
LEU D 353
PRO C 309
ILE D 337
LEU C 331
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 4
LEU B 353
PRO A 309
ILE B 337
LEU A 331
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
ALA B 264
GLY A 316
SER A 318
LEU B 291
LEU B 353
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_2
(CES1 PROTEIN)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 4
LEU B 353
PRO A 309
ILE B 337
LEU A 331
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
ALA A 264
GLY B 316
SER B 318
LEU A 291
LEU A 353
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 4
LEU A 353
PRO B 309
ILE A 337
LEU B 331
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_2
(CES1 PROTEIN)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 4
LEU E 353
PRO F 309
ILE E 337
LEU F 331
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
ALA E 264
GLY F 316
SER F 318
LEU E 291
LEU E 353
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
ALA C 264
GLY D 316
SER D 318
LEU C 291
LEU C 353
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_2
(CES1 PROTEIN)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 4
LEU C 353
PRO D 309
ILE C 337
LEU D 331
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
ALA F 264
GLY E 316
SER E 318
LEU F 291
LEU F 353
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 4
LEU C 353
PRO D 309
ILE C 337
LEU D 331
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 4
LEU E 339
PRO E 309
ILE F 320
LEU E 353
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 4
LEU D 353
PRO C 309
ILE D 337
LEU C 331
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_2
(CES1 PROTEIN)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 4
LEU F 353
PRO E 309
ILE F 337
LEU E 331
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 4
LEU F 353
PRO E 309
ILE F 337
LEU E 331
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 4
LEU E 353
PRO F 309
ILE E 337
LEU F 331
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 4
LEU A7010
PRO A6860
ILE A7080
LEU A6961
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_2
(CES1 PROTEIN)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 4
LEU A7010
PRO A6860
ILE A7080
LEU A6961
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 4
LEU C7010
PRO C6860
ILE C7080
LEU C6961
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
TRP C7029
PRO C6810
MET C6809
LEU C6812
1.74A
None
FMT  C7105 (-4.6A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
MET A7068
LEU A7073
GLY A7076
LEU A7010
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
TRP A7029
PRO A6810
MET A6809
LEU A6812
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_2
(CES1 PROTEIN)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 4
LEU C7010
PRO C6860
ILE C7080
LEU C6961
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 7
GLY C 129
LYS C 127
LEU C 121
PRO C 117
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 8
LEU B 161
GLY B  71
LEU B  56
PRO B 168
1.32A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 8
LEU D 161
GLY D  71
LEU D  56
PRO D 168
1.33A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 8
GLY C 129
LYS C 127
LEU C 121
PRO C 117
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 8
LEU A 161
GLY A  71
LEU A  56
PRO A 168
1.34A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		6wkq NSP16
(SARS-CoV-2)		4 / 8
MET A7068
LEU A7073
GLY A7076
LEU A7010
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		6wkq NSP16
(SARS-CoV-2)		4 / 8
TRP C7029
PRO C6810
MET C6809
LEU C6812
1.74A
None
FMT  C7109 ( 4.5A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		6wkq NSP16
(SARS-CoV-2)		4 / 4
LEU A7010
PRO A6860
ILE A7080
LEU A6961
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_2
(CES1 PROTEIN)		6wkq NSP16
(SARS-CoV-2)		4 / 4
LEU C7010
PRO C6860
ILE C7080
LEU C6961
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		6wkq NSP16
(SARS-CoV-2)		4 / 4
LEU C7010
PRO C6860
ILE C7080
LEU C6961
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_2
(CES1 PROTEIN)		6wkq NSP16
(SARS-CoV-2)		4 / 4
LEU A7010
PRO A6860
ILE A7080
LEU A6961
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 8
LEU B 249
GLY B 248
LEU B 255
PRO B 344
1.71A
None
U5P  B 401 ( 4.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
GLY B 247
SER B 288
SER B 294
LEU B 249
LEU B 266
1.50A
None
None
U5P  B 401 (-2.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 7
PRO B 206
GLY B 254
LYS B 257
LEU B 215
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
GLY A 247
SER A 288
SER A 294
LEU A 249
LEU A 266
1.49A
None
None
U5P  A 401 (-2.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 8
LEU A 249
GLY A 248
LEU A 255
PRO A 344
1.70A
None
U5P  A 401 ( 4.5A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 7
LEU A 249
GLY A 248
LEU A 255
PRO A 344
1.74A
None
U5P  A 401 ( 4.5A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 7
PRO A 206
GLY A 254
LYS A 257
LEU A 215
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 7
LEU B 249
GLY B 248
LEU B 255
PRO B 344
1.75A
None
U5P  B 401 ( 4.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
GLY A  23
VAL A  20
SER A  62
LEU A  57
LEU A  89
1.35A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
GLY A  23
VAL A  20
SER A  62
LEU A  57
LEU A  89
1.34A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
ALA D  38
GLY D  79
GLY D  78
SER D 139
LEU D 108
1.27A
APR  D 201 (-3.2A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL D  49
LEU D 127
SER D 128
LEU D  75
HIS D  94
1.43A
APR  D 201 (-3.6A)
None
APR  D 201 (-4.3A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
ALA B  39
GLY B  79
GLY B  78
LEU B 108
LEU B 127
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL A  49
LEU A 127
SER A 128
LEU A  75
HIS A  94
1.38A
APR  A 201 (-3.8A)
None
APR  A 201 (-4.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
ALA A  38
GLY A  79
GLY A  78
SER A 139
LEU A 108
1.25A
APR  A 201 (-3.5A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL B  49
LEU B 127
SER B 128
LEU B  75
HIS B  94
1.45A
APR  B 201 (-3.7A)
None
APR  B 201 (-4.5A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL C  49
LEU C 127
SER C 128
LEU C  75
HIS C  94
1.38A
APR  C 201 (-3.8A)
None
APR  C 201 (-4.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
ALA D  39
GLY D  79
GLY D  78
LEU D 108
LEU D 127
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 8
PRO D 125
GLY D  85
LEU D  53
PRO D  32
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
ALA B  38
GLY B  79
GLY B  78
SER B 139
LEU B 108
1.23A
APR  B 201 (-3.3A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 7
PRO D 125
GLY D  85
LEU D  53
PRO D  32
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL A  49
LEU A 127
SER A 128
LEU A  75
HIS A  94
1.41A
APR  A 201 (-3.8A)
None
APR  A 201 (-4.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
ALA A  39
GLY A  79
GLY A  78
LEU A 108
LEU A 127
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL B  49
LEU B 127
SER B 128
LEU B  75
HIS B  94
1.41A
APR  B 201 (-3.7A)
None
APR  B 201 (-4.5A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
ALA C  38
GLY C  79
GLY C  78
SER C 139
LEU C 108
1.25A
APR  C 201 (-3.4A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL C  49
LEU C 127
SER C 128
LEU C  75
HIS C  94
1.36A
APR  C 201 (-3.8A)
None
APR  C 201 (-4.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
ALA C  39
GLY C  79
GLY C  78
LEU C 108
LEU C 127
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 4
LEU A7010
PRO A6860
ILE A7080
LEU A6961
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
GLY A6890
VAL A6865
LEU A6893
LEU A7052
LEU A6924
1.44A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_2
(CES1 PROTEIN)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 4
LEU A7010
PRO A6860
ILE A7080
LEU A6961
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
GLY A6890
VAL A6865
LEU A6893
LEU A7052
LEU A6924
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 8
TRP A7029
PRO A6810
MET A6809
LEU A6812
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		6wqd NSP7
NSP8
(SARS-CoV-2)		5 / 12
LEU C  55
SER C  54
LEU C  17
LEU D  98
LEU C  60
1.18A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		6wqd NSP7
NSP8
(SARS-CoV-2)		6 / 12
LEU A  55
SER A  54
LEU A  59
LEU A  40
MET A  52
LEU B  95
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		6wqd NSP7
NSP8
(SARS-CoV-2)		5 / 12
PHE B  92
LEU A  55
LEU A  14
LEU A  60
LEU A  28
1.44A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_2
(CES1 PROTEIN)		6wqd NSP7
NSP8
(SARS-CoV-2)		4 / 4
LEU A  59
PRO B 121
ILE B 106
LEU A  56
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		6wqd NSP7
NSP8
(SARS-CoV-2)		5 / 12
PHE B  92
VAL A  22
LEU A  55
LEU A  60
LEU A  28
1.22A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		6wqd NSP7
NSP8
(SARS-CoV-2)		6 / 12
LEU C  55
SER C  54
LEU C  59
LEU C  40
MET C  52
LEU D  95
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		6wqd NSP7
NSP8
(SARS-CoV-2)		5 / 12
PHE D  92
LEU C  55
LEU C  14
LEU C  60
LEU C  28
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		6wqd NSP7
NSP8
(SARS-CoV-2)		5 / 12
LEU C  55
SER C  54
LEU C  17
LEU D  98
LEU C  60
1.22A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		6wqd NSP7
NSP8
(SARS-CoV-2)		5 / 12
LEU C  55
SER C  54
LEU C  59
MET C  52
LEU D  95
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		6wqd NSP7
NSP8
(SARS-CoV-2)		5 / 12
PHE B  92
VAL A  22
LEU A  55
LEU A  60
LEU A  28
1.20A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		6wqd NSP7
NSP8
(SARS-CoV-2)		5 / 12
PHE D  92
VAL C  22
LEU C  14
LEU C  56
LEU C  28
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_2
(CES1 PROTEIN)		6wqd NSP7
NSP8
(SARS-CoV-2)		4 / 4
LEU A  13
PRO B 121
ILE B 106
LEU B 103
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		6wqd NSP8
(SARS-CoV-2)		5 / 12
GLY D 144
VAL D 159
SER D 173
LEU D 169
LEU D 184
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		6wqd NSP7
NSP8
(SARS-CoV-2)		5 / 12
PHE D  92
VAL C  22
LEU C  55
LEU C  60
LEU C  28
1.22A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		6wqd NSP7
NSP8
(SARS-CoV-2)		4 / 4
LEU A  13
PRO B 121
ILE B 106
LEU B 103
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		6wqd NSP7
NSP8
(SARS-CoV-2)		4 / 4
LEU A  59
PRO B 121
ILE B 106
LEU A  56
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		6wqd NSP7
NSP8
(SARS-CoV-2)		5 / 12
LEU C  55
SER C  10
LEU C  56
LEU C  14
LEU D  91
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		6wqd NSP8
(SARS-CoV-2)		5 / 12
GLY D 144
VAL D 159
SER D 173
LEU D 169
LEU D 184
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		6wqd NSP7
(SARS-CoV-2)		5 / 12
VAL A  16
LEU A  60
SER A  61
MET A  62
LEU A  20
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		6wqd NSP7
NSP8
(SARS-CoV-2)		5 / 12
PHE D  92
LEU C  55
LEU C  14
LEU C  60
LEU C  28
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		6wqd NSP7
NSP8
(SARS-CoV-2)		5 / 12
LEU C  14
SER C  10
LEU C  17
LEU A  14
LEU D  91
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		6wqd NSP7
NSP8
(SARS-CoV-2)		5 / 12
LEU A  55
SER A  54
LEU A  17
LEU B  98
LEU A  60
1.18A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		6wqd NSP7
NSP8
(SARS-CoV-2)		4 / 4
LEU C  59
PRO D 121
ILE D 106
LEU C  56
1.41A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		6wqd NSP7
NSP8
(SARS-CoV-2)		5 / 12
LEU C  14
SER C  10
LEU C  17
LEU A  14
LEU D  91
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		6wqd NSP7
NSP8
(SARS-CoV-2)		5 / 12
PHE D  92
VAL C  22
LEU C  55
LEU C  60
LEU C  28
1.19A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		6wqd NSP7
NSP8
(SARS-CoV-2)		5 / 12
PHE B  92
VAL A  22
LEU A  14
LEU A  56
LEU A  28
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		6wqd NSP8
(SARS-CoV-2)		5 / 12
GLY B 144
VAL B 159
SER B 173
LEU B 169
LEU B 184
1.44A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		6wqd NSP7
NSP8
(SARS-CoV-2)		5 / 12
LEU A  55
SER A  54
LEU A  17
LEU B  98
LEU A  60
1.22A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_2
(CES1 PROTEIN)		6wqd NSP7
NSP8
(SARS-CoV-2)		4 / 4
LEU C  13
PRO D 121
ILE D 106
LEU D 103
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		6wqd NSP7
(SARS-CoV-2)		5 / 12
VAL C  16
LEU C  60
SER C  61
MET C  62
LEU C  20
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		6wqd NSP7
NSP8
(SARS-CoV-2)		5 / 12
PHE B  92
LEU A  55
LEU A  14
LEU A  60
LEU A  28
1.47A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		6wqd NSP8
(SARS-CoV-2)		5 / 12
GLY B 144
VAL B 159
SER B 173
LEU B 169
LEU B 184
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		6wqd NSP7
NSP8
(SARS-CoV-2)		4 / 4
LEU C  13
PRO D 121
ILE D 106
LEU D 103
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		6wqd NSP7
NSP8
(SARS-CoV-2)		5 / 12
LEU A  55
SER A  54
LEU A  59
MET A  52
LEU B  95
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_2
(CES1 PROTEIN)		6wqd NSP7
NSP8
(SARS-CoV-2)		4 / 4
LEU C  59
PRO D 121
ILE D 106
LEU C  56
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		6wqd NSP7
NSP8
(SARS-CoV-2)		5 / 12
PHE B  92
VAL A  22
LEU A  14
LEU A  56
LEU A  28
1.46A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
GLY A  23
VAL A  20
SER A  62
LEU A  57
LEU A  89
1.39A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
GLY A  23
VAL A  20
SER A  62
LEU A  57
LEU A  89
1.40A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU A 271
SER A 267
LEU A 272
LEU A 282
LEU A 205
1.77A14.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
PHE A 140
GLY A 146
VAL A  13
LEU A 177
LEU A  30
1.66A14.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
PHE A 159
GLY A  29
VAL A  68
SER A  81
LEU A  32
1.61A14.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
GLY A  23
VAL A  20
SER A  62
LEU A  57
LEU A  89
1.38A14.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
GLY A  23
SER A  62
LEU A  67
LEU A  57
LEU A  89
1.56A14.26
None
None
DMS  A 402 ( 4.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
PHE A 159
GLY A 146
VAL A  20
LEU A  27
LEU A  32
1.73A14.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
PHE A 140
GLY A 146
VAL A  13
LEU A 177
LEU A  30
1.64A14.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
GLY A  23
SER A  62
LEU A  67
LEU A  57
LEU A  89
1.55A14.26
None
None
DMS  A 402 ( 4.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL A  20
LEU A  87
LEU A  89
LEU A  57
LEU A  27
1.75A14.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
GLY A  23
VAL A  20
SER A  62
LEU A  57
LEU A  89
1.39A14.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU A 268
SER A 267
LEU A 272
LEU A 250
HIS A 246
1.66A14.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
PHE A 159
GLY A  29
VAL A  68
SER A  81
LEU A  32
1.66A14.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU A 271
SER A 267
LEU A 272
LEU A 282
LEU A 205
1.75A14.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
PHE A 159
GLY A 146
VAL A  20
LEU A  27
LEU A  32
1.72A14.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU A 268
SER A 267
LEU A 272
LEU A 250
HIS A 246
1.71A14.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		6 / 12
LEU C  55
SER C  54
LEU C  59
LEU C  40
MET C  52
LEU D  95
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
PHE D  92
LEU C  55
LEU C  14
LEU C  60
LEU C  28
1.42A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
GLY A  64
LEU A  59
LEU A  20
LEU A  60
LEU A  28
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 4
LEU C  59
PRO D 121
ILE D 106
LEU C  56
1.44A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_2
(CES1 PROTEIN)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 4
LEU C  59
PRO D 121
ILE D 106
LEU C  56
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 4
LEU C  13
PRO D 121
ILE D 106
LEU D 103
1.47A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
PHE D  92
VAL C  22
LEU C  55
LEU C  60
LEU C  28
1.19A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
LEU A  14
SER A  10
LEU A  17
LEU C  14
LEU B  91
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
LEU C  55
SER C  54
LEU C  17
LEU D  98
LEU C  60
1.17A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 4
LEU A  13
PRO B 121
ILE B 106
LEU B 103
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
LEU C  14
SER C  10
LEU C  17
LEU A  14
LEU D  91
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
PHE B  92
LEU A  55
LEU A  14
LEU A  60
LEU A  28
1.37A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
PHE D  92
LEU C  55
LEU C  14
LEU C  60
LEU C  28
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
PHE B  92
VAL A  22
LEU A  14
LEU A  56
LEU A  28
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
PHE B  92
VAL A  22
LEU A  55
LEU A  60
LEU A  28
1.13A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
PHE D  92
VAL C  22
LEU C  55
LEU C  60
LEU C  28
1.16A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		6 / 12
LEU A  55
SER A  54
LEU A  59
LEU A  40
MET A  52
LEU B  95
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_2
(CES1 PROTEIN)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 4
LEU A  59
PRO B 121
ILE B 106
LEU A  56
1.43A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
PHE B  92
VAL A  22
LEU A  55
LEU A  60
LEU A  28
1.17A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
VAL A  16
LEU A  60
SER A  61
MET A  62
LEU A  20
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
GLY B 144
VAL B 159
SER B 173
LEU B 169
LEU B 184
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
LEU A  55
SER A  54
LEU A  59
MET A  52
LEU B  95
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
LEU A  55
SER A  54
LEU A  17
LEU B  98
LEU A  60
1.23A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_2
(CES1 PROTEIN)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 4
LEU A  13
PRO B 121
ILE B 106
LEU B 103
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
LEU C  55
SER C  54
LEU C  59
MET C  52
LEU D  95
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
LEU C  55
SER C  54
LEU C  17
LEU D  98
LEU C  60
1.20A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
LEU C  55
SER C  10
LEU C  56
LEU C  14
LEU D  91
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_2
(CES1 PROTEIN)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 4
LEU C  13
PRO D 121
ILE D 106
LEU D 103
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
GLY C  64
LEU C  59
LEU C  20
LEU C  60
LEU C  28
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 4
LEU A  59
PRO B 121
ILE B 106
LEU A  56
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
PHE B  92
LEU A  55
LEU A  14
LEU A  60
LEU A  28
1.41A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
ALA B 110
LEU A  60
SER A  61
MET A  62
LEU A  20
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
PHE D  92
VAL C  22
LEU C  14
LEU C  56
LEU C  28
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
LEU A  55
SER A  54
LEU A  17
LEU B  98
LEU A  60
1.25A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		6yla HEAVY CHAIN
(Homo
sapiens)		4 / 7
LEU B  86
GLY B  15
LYS B  12
LEU B  18
1.69A
None
None
DMS  H 302 (-3.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 8
PRO L 125
LEU H 128
GLY H 143
PRO H 217
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		6yla HEAVY CHAIN
(Homo
sapiens)		4 / 7
PRO H 130
LEU H 193
GLY H 194
LEU H 142
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		6yla HEAVY CHAIN
(Homo
sapiens)		4 / 8
PRO H 130
LEU H 193
GLY H 194
LEU H 142
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 7
PRO C 125
LEU B 128
GLY B 143
PRO B 217
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 8
TRP H 109
MET H 106
LEU H   4
PRO L  49
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		6yla HEAVY CHAIN
(Homo
sapiens)		4 / 8
PRO B 130
LEU B 193
GLY B 194
LEU B 142
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 7
PRO L 125
LEU H 128
GLY H 143
PRO H 217
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		6yla HEAVY CHAIN
(Homo
sapiens)		4 / 7
PRO B 130
LEU B 193
GLY B 194
LEU B 142
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 8
PRO H 217
LEU H 142
GLY H 143
PRO L 125
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 8
PRO C 125
LEU B 128
GLY B 143
PRO B 217
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 8
PRO B 217
LEU B 142
GLY B 143
PRO C 125
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 7
PRO B 217
LEU B 142
GLY B 143
PRO C 125
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		6yla HEAVY CHAIN
(Homo
sapiens)		5 / 12
ALA H 141
GLY H 138
GLY H 137
SER H 131
LEU H 193
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 7
PRO H 217
LEU H 142
GLY H 143
PRO L 125
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		6ym0 HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 8
PRO H 217
LEU H 142
GLY H 143
PRO L 125
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		6ym0 HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 7
PRO H 217
LEU H 142
GLY H 143
PRO L 125
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		6ym0 HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		5 / 12
ALA H 141
PHE L 215
LEU L 141
LEU L 142
LEU H 128
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		6ym0 HEAVY CHAIN
(Homo
sapiens)		4 / 8
PRO H 130
LEU H 193
GLY H 194
LEU H 142
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		6ym0 HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 7
PRO L 125
LEU H 128
GLY H 143
PRO H 217
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		6ym0 HEAVY CHAIN
(Homo
sapiens)		4 / 7
PRO H 130
LEU H 193
GLY H 194
LEU H 142
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		6ym0 HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 8
PRO L 125
LEU H 128
GLY H 143
PRO H 217
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		6ym0 HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		5 / 12
ALA H 141
PHE L 215
SER H 184
LEU L 181
LEU H 128
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		6ym0 HEAVY CHAIN
(Homo
sapiens)		4 / 7
LEU H  86
GLY H  15
LYS H  12
LEU H  18
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		6ym0 HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		4 / 8
TRP H 109
MET H 106
LEU H   4
PRO L  49
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
GLY A  23
VAL A  20
SER A  62
LEU A  57
LEU A  89
1.40A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
GLY A  23
VAL A  20
SER A  62
LEU A  57
LEU A  89
1.40A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		4 / 8
PRO L 125
LEU H 128
GLY H 143
PRO H 217
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		6yor IGG H CHAIN
(Homo
sapiens)		5 / 12
ALA H 141
GLY H 138
GLY H 137
SER H 131
LEU H 193
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		4 / 7
PRO L 125
LEU H 128
GLY H 143
PRO H 217
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		4 / 8
PRO H 217
LEU H 142
GLY H 143
PRO L 125
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		6yor IGG H CHAIN
(Homo
sapiens)		5 / 12
ALA B 141
GLY B 138
GLY B 137
SER B 131
LEU B 193
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		6yor IGG H CHAIN
(Homo
sapiens)		4 / 8
PRO H 130
LEU H 193
GLY H 194
LEU H 142
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		4 / 7
PRO H 217
LEU H 142
GLY H 143
PRO L 125
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		6yor IGG H CHAIN
(Homo
sapiens)		4 / 7
PRO B 130
LEU B 193
GLY B 194
LEU B 142
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		4 / 8
PRO C 125
LEU B 128
GLY B 143
PRO B 217
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		4 / 7
PRO C 125
LEU B 128
GLY B 143
PRO B 217
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		4 / 8
PRO B 217
LEU B 142
GLY B 143
PRO C 125
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		6yor IGG H CHAIN
(Homo
sapiens)		4 / 8
PRO B 130
LEU B 193
GLY B 194
LEU B 142
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		4 / 8
TRP H 109
MET H 106
LEU H   4
PRO L  49
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		4 / 8
TRP B 109
MET B 106
LEU B   4
PRO C  49
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		6yor IGG H CHAIN
(Homo
sapiens)		4 / 7
PRO H 130
LEU H 193
GLY H 194
LEU H 142
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		6yor IGG H CHAIN
IGG L CHAIN
(Homo
sapiens)		4 / 7
PRO B 217
LEU B 142
GLY B 143
PRO C 125
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
GLY A  23
SER A  62
LEU A  67
LEU A  57
LEU A  89
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
GLY A  23
VAL A  20
SER A  62
LEU A  57
LEU A  89
1.39A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
GLY A  23
VAL A  20
SER A  62
LEU A  57
LEU A  89
1.39A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL A  49
LEU A 127
SER A 128
LEU A  75
HIS A  94
1.38A
None
EDO  A 202 ( 4.8A)
EDO  A 202 (-4.3A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ALA C  38
GLY C  79
GLY C  78
SER C 139
LEU C 108
1.37A
None
EPE  C 202 (-3.4A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 7
PRO E 125
GLY E  85
LEU E  53
PRO E  32
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ALA D  39
GLY D  79
GLY D  78
LEU D 108
LEU D 127
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL C  49
LEU C 127
SER C 128
LEU C  75
HIS C  94
1.34A
None
None
None
EPE  C 202 (-3.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ALA A  38
GLY A  79
GLY A  78
SER A 139
LEU A 108
1.32A
EDO  A 202 (-3.3A)
None
None
None
EDO  D 202 ( 4.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
PRO A 125
GLY A  85
LEU A  53
PRO A  32
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ALA D  27
GLY D  85
LEU D  88
LEU D  53
HIS D  94
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 7
PRO A 125
GLY A  85
LEU A  53
PRO A  32
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL A  49
LEU A 127
SER A 128
LEU A  75
HIS A  94
1.41A
None
EDO  A 202 ( 4.8A)
EDO  A 202 (-4.3A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL B  49
LEU B 127
SER B 128
LEU B  75
HIS B  94
1.34A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ALA B  27
GLY B  85
LEU B  88
LEU B  53
HIS B  94
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ALA C  39
GLY C  79
GLY C  78
LEU C 108
LEU C 127
1.62A
None
EPE  C 202 (-3.4A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL E  49
LEU E 127
SER E 128
LEU E  75
HIS E  94
1.35A
None
None
EPE  E 202 (-4.6A)
EPE  E 203 (-3.6A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ALA E  38
GLY E  79
GLY E  78
SER E 139
LEU E 108
1.30A
EPE  E 202 (-3.3A)
EPE  E 203 (-3.3A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL D  49
LEU D 127
SER D 128
LEU D  75
HIS D  94
1.37A
EDO  D 209 (-4.6A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL C  49
LEU C 127
SER C 128
LEU C  75
HIS C  94
1.37A
None
None
None
EPE  C 202 (-3.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL B  49
LEU B 127
SER B 128
LEU B  75
HIS B  94
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL E  49
LEU E 127
SER E 128
LEU E  75
HIS E  94
1.33A
None
None
EPE  E 202 (-4.6A)
EPE  E 203 (-3.6A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ALA A  27
GLY A  85
LEU A  88
LEU A  53
HIS A  94
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ALA A  39
GLY A  79
GLY A  78
LEU A 108
LEU A 127
1.62A
None
None
None
EDO  D 202 ( 4.8A)
EDO  A 202 ( 4.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ALA C  39
GLY C  79
GLY C  78
LEU C 108
LEU C 127
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ALA E  38
GLY E  79
GLY E  78
SER E 139
LEU E 108
1.30A
APR  E 201 (-3.3A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL B  49
LEU B 127
SER B 128
LEU B  75
HIS B  94
1.42A
APR  B 201 (-3.7A)
None
APR  B 201 (-4.3A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY B  51
GLY B  47
VAL E 100
SER B 128
LEU B  43
1.51A
None
APR  B 201 (-3.6A)
None
APR  B 201 (-4.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ALA B  38
GLY B  79
GLY B  78
SER B 139
LEU B 108
1.34A
APR  B 201 (-3.4A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ALA A  38
GLY A  79
GLY A  78
SER A 139
LEU A 108
1.33A
APR  A 201 (-3.4A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ALA C  38
GLY C  79
GLY C  78
SER C 139
LEU C 108
1.33A
APR  C 201 (-3.4A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ALA E  39
GLY E  79
GLY E  78
LEU E 108
LEU E 127
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL C  49
LEU C 127
SER C 128
LEU C  75
HIS C  94
1.41A
APR  C 201 (-3.6A)
None
APR  C 201 (-4.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ALA B  39
GLY B  79
GLY B  78
LEU B 108
LEU B 127
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ALA D  39
GLY D  79
GLY D  78
LEU D 108
LEU D 127
1.57A
None
EDO  D 203 (-3.1A)
None
EDO  A 206 (-4.6A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL E  49
LEU E 127
SER E 128
LEU E  75
HIS E  94
1.40A
APR  E 201 (-3.7A)
None
APR  E 201 (-4.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL C  49
LEU C 127
SER C 128
LEU C  75
HIS C  94
1.37A
APR  C 201 (-3.6A)
None
APR  C 201 (-4.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL D  49
LEU D 127
SER D 128
LEU D  75
HIS D  94
1.40A
APR  D 201 (-3.7A)
None
APR  D 201 (-4.3A)
EDO  D 202 (-4.6A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL A  49
LEU A 127
SER A 128
LEU A  75
HIS A  94
1.43A
APR  A 201 (-3.7A)
None
APR  A 201 (-4.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL E  49
LEU E 127
SER E 128
LEU E  75
HIS E  94
1.36A
APR  E 201 (-3.7A)
None
APR  E 201 (-4.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL A  49
LEU A 127
SER A 128
LEU A  75
HIS A  94
1.40A
APR  A 201 (-3.7A)
None
APR  A 201 (-4.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL D  49
LEU D 127
SER D 128
LEU D  75
HIS D  94
1.43A
APR  D 201 (-3.7A)
None
APR  D 201 (-4.3A)
EDO  D 202 (-4.6A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ALA A  39
GLY A  79
GLY A  78
LEU A 108
LEU A 127
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL B  49
LEU B 127
SER B 128
LEU B  75
HIS B  94
1.39A
APR  B 201 (-3.7A)
None
APR  B 201 (-4.3A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ALA D  38
GLY D  79
GLY D  78
SER D 139
LEU D 108
1.34A
APR  D 201 (-3.3A)
EDO  D 203 (-3.1A)
None
None
EDO  A 206 (-4.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ALA C  27
GLY C  85
LEU C  88
LEU C  53
HIS C  94
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ALA B  38
GLY B  79
GLY B  78
SER B 139
LEU B 108
1.35A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
PRO B 125
GLY B  85
LEU B  53
PRO B  32
1.80A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL C  49
LEU C 127
SER C 128
LEU C  75
HIS C  94
1.40A
None
None
MES  C 201 (-4.6A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 8
PRO A 125
GLY A  85
LEU A  53
PRO A  32
1.80A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ALA C  38
GLY C  79
GLY C  78
SER C 139
LEU C 108
1.37A
MES  C 201 (-3.5A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL A  49
LEU A 127
SER A 128
LEU A  75
HIS A  94
1.42A
None
None
MES  A 201 (-4.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL C  49
LEU C 127
SER C 128
LEU C  75
HIS C  94
1.37A
None
None
MES  C 201 (-4.6A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL B  49
LEU B 127
SER B 128
LEU B  75
HIS B  94
1.35A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 7
PRO B 125
GLY B  85
LEU B  53
PRO B  32
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ALA A  38
GLY A  79
GLY A  78
SER A 139
LEU A 108
1.32A
MES  A 201 (-3.5A)
EDO  A 204 (-3.6A)
None
None
EDO  C 205 (-4.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ALA A  39
GLY A  79
GLY A  78
LEU A 108
LEU A 127
1.65A
None
EDO  A 204 (-3.6A)
None
EDO  C 205 (-4.9A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL B  49
LEU B 127
SER B 128
LEU B  75
HIS B  94
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_2
(CES1 PROTEIN)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 4
LEU C 127
PRO C  32
ILE C  23
LEU C 153
1.78A
None
None
EDO  C 206 (-4.1A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 7
PRO A 125
GLY A  85
LEU A  53
PRO A  32
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL A  49
LEU A 127
SER A 128
LEU A  75
HIS A  94
1.40A
None
None
MES  A 201 (-4.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		7bqy MAIN PROTEASE
(SARS-CoV-2)		5 / 12
GLY A  23
VAL A  20
SER A  62
LEU A  57
LEU A  89
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		7bqy MAIN PROTEASE
(SARS-CoV-2)		5 / 12
GLY A  23
VAL A  20
SER A  62
LEU A  57
LEU A  89
1.46A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		7btf NSP12
(SARS-CoV-2)		5 / 12
ALA A 702
PHE A 694
SER A 784
LEU A 786
LEU A 247
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		7btf NSP12
NSP7
NSP8
(SARS-CoV-2)		5 / 12
PHE A 440
LEU C  55
SER C  54
MET C  52
LEU D  95
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		7btf NSP7
NSP8
(SARS-CoV-2)		5 / 12
LEU C  55
SER C  54
LEU C  59
MET C  52
LEU D 103
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		7btf NSP12
(SARS-CoV-2)		5 / 12
PHE A 859
GLY A 841
GLY A 839
LEU A 437
LEU A 883
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		7btf NSP12
NSP8
(SARS-CoV-2)		4 / 8
MET A 380
LEU A 401
LEU A 673
PRO B 121
1.16A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		7btf NSP12
NSP8
(SARS-CoV-2)		6 / 12
PHE A 407
GLY A 670
GLY A 671
LEU A 388
LEU A 401
MET B 129
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		7btf NSP7
NSP8
(SARS-CoV-2)		5 / 12
LEU C  55
SER C  54
LEU C  17
LEU D  98
LEU C  60
1.25A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		7btf NSP12
(SARS-CoV-2)		5 / 12
ALA A 866
PHE A 859
GLY A 841
GLY A 839
LEU A 883
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_2
(CES1 PROTEIN)		7btf NSP7
NSP8
(SARS-CoV-2)		4 / 4
LEU C  59
PRO D 121
ILE D 106
LEU C  56
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		7btf NSP12
NSP7
(SARS-CoV-2)		5 / 12
GLY A 841
GLY A 839
LEU A 437
SER C   4
LEU C  40
1.35A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		7btf NSP7
NSP8
(SARS-CoV-2)		5 / 12
ALA D 110
LEU C  60
SER C  61
MET C  62
LEU C  20
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		7btf NSP12
(SARS-CoV-2)		4 / 4
LEU A 469
PRO A 461
ILE A 632
LEU A 630
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		7btf NSP7
NSP8
(SARS-CoV-2)		6 / 12
SER C  15
LEU C  55
SER C  54
LEU C  59
MET C  52
LEU D  95
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_2
(CES1 PROTEIN)		7btf NSP12
(SARS-CoV-2)		4 / 4
LEU A 469
PRO A 461
ILE A 632
LEU A 630
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		7btf NSP12
NSP8
(SARS-CoV-2)		5 / 12
ALA A 375
SER A 363
LEU B  91
LEU B  95
LEU A 371
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		7btf NSP12
NSP8
(SARS-CoV-2)		4 / 8
PRO A 378
MET A 380
LEU A 673
PRO B 121
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		7btf NSP12
NSP7
(SARS-CoV-2)		5 / 12
GLY A 841
GLY A 839
LEU A 437
SER C   4
LEU C  40
1.46A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		7btf NSP12
NSP7
NSP8
(SARS-CoV-2)		5 / 12
PHE A 440
LEU C  55
SER C  54
MET C  52
LEU D  95
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		7btf NSP7
NSP8
(SARS-CoV-2)		5 / 12
LEU C  55
SER C  54
LEU C  17
LEU D  98
LEU C  60
1.20A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		7btf NSP7
(SARS-CoV-2)		5 / 12
VAL C  16
LEU C  60
SER C  61
MET C  62
LEU C  20
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		7btf NSP7
NSP8
(SARS-CoV-2)		5 / 12
PHE D  92
VAL C  22
LEU C  55
LEU C  60
LEU C  28
1.42A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		7btf NSP8
(SARS-CoV-2)		5 / 12
GLY B 144
VAL B 159
SER B 173
LEU B 169
LEU B 184
1.34A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		7btf NSP12
NSP8
(SARS-CoV-2)		6 / 12
PHE A 407
GLY A 670
GLY A 671
LEU A 388
LEU A 401
MET B 129
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		7btf NSP12
(SARS-CoV-2)		5 / 12
PHE A 368
VAL A 495
SER A 501
LEU A 498
LEU A 372
1.47A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		7btf NSP12
NSP7
(SARS-CoV-2)		5 / 12
GLY A 841
GLY A 839
LEU A 437
SER C   4
LEU C  40
1.47A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		7btf NSP7
NSP8
(SARS-CoV-2)		5 / 12
PHE D  92
VAL C  22
LEU C  55
LEU C  60
LEU C  28
1.41A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		7btf NSP12
NSP7
(SARS-CoV-2)		5 / 12
ALA A 443
SER C  25
LEU C  14
SER C  15
LEU C  20
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		7btf NSP7
(SARS-CoV-2)		5 / 12
GLY C  64
LEU C  59
LEU C  20
LEU C  60
LEU C  28
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		7btf NSP12
NSP7
NSP8
(SARS-CoV-2)		5 / 12
PHE A 440
LEU C  55
SER C  54
MET C  52
LEU D  95
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		7btf NSP12
NSP8
(SARS-CoV-2)		6 / 12
PHE A 407
GLY A 670
GLY A 671
LEU A 388
LEU A 401
MET B 129
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		7btf NSP12
(SARS-CoV-2)		4 / 4
LEU A 883
PRO A 868
ILE A 837
LEU A 838
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		7btf NSP12
(SARS-CoV-2)		5 / 12
PHE A 368
VAL A 495
SER A 501
LEU A 498
LEU A 372
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		7btf NSP12
NSP7
NSP8
(SARS-CoV-2)		5 / 12
ALA A 443
LEU C  14
SER C  10
LEU C  17
LEU D  91
1.43A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		7btf NSP7
NSP8
(SARS-CoV-2)		4 / 4
LEU C  59
PRO D 121
ILE D 106
LEU C  56
1.40A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		7btf NSP12
(SARS-CoV-2)		4 / 4
LEU A 470
PRO A 296
ILE A 307
LEU A 308
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		7btf NSP12
NSP7
(SARS-CoV-2)		5 / 12
ALA A 443
LEU C  14
SER C  15
LEU C  55
LEU C  59
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_2
(CES1 PROTEIN)		7btf NSP12
(SARS-CoV-2)		4 / 4
LEU A 470
PRO A 296
ILE A 307
LEU A 308
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		7btf NSP7
(SARS-CoV-2)		5 / 12
VAL C  16
LEU C  60
SER C  61
MET C  62
LEU C  20
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		7btf NSP12
NSP7
(SARS-CoV-2)		5 / 12
ALA A 423
GLY A 841
GLY A 839
SER C   4
LEU C  40
0.98A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		5 / 12
GLY A  23
VAL A  20
SER A  62
LEU A  57
LEU A  89
1.39A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		5 / 12
GLY A  23
VAL A  20
SER A  62
LEU A  57
LEU A  89
1.31A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
PHE A 368
VAL A 495
SER A 501
LEU A 498
LEU A 372
1.43A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		7bv1 NSP7
NSP8
(SARS-CoV-2)		5 / 12
PHE D  92
LEU C  55
LEU C  14
LEU C  60
LEU C  28
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		7bv1 NSP8
(SARS-CoV-2)		5 / 12
GLY B 144
VAL B 159
SER B 173
LEU B 169
LEU B 184
1.26A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
PHE A 859
GLY A 841
GLY A 839
LEU A 437
LEU A 883
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		7bv1 NSP12
NSP8
(SARS-CoV-2)		6 / 12
PHE A 407
GLY A 670
GLY A 671
LEU A 388
LEU A 401
MET B 129
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		7bv1 NSP12
NSP8
(SARS-CoV-2)		6 / 12
PHE A 407
GLY A 670
GLY A 671
LEU A 388
LEU A 401
MET B 129
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		7bv1 NSP7
NSP8
(SARS-CoV-2)		5 / 12
LEU C  55
SER C  54
LEU C  17
LEU D  98
LEU C  60
1.22A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		7bv1 NSP7
NSP8
(SARS-CoV-2)		4 / 4
LEU C  59
PRO D 121
ILE D 106
LEU C  56
1.39A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_2
(CES1 PROTEIN)		7bv1 NSP7
NSP8
(SARS-CoV-2)		4 / 4
LEU C  13
PRO D 116
ILE D 107
LEU D 103
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		7bv1 NSP7
(SARS-CoV-2)		5 / 12
GLY C  64
LEU C  59
LEU C  20
LEU C  60
LEU C  28
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		7bv1 NSP7
NSP8
(SARS-CoV-2)		5 / 12
ALA D 110
LEU C  60
SER C  61
MET C  62
LEU C  17
1.42A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		7bv1 NSP12
(SARS-CoV-2)		4 / 8
PRO A 243
MET A 242
LEU A 247
LEU A 131
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		7bv1 NSP8
(SARS-CoV-2)		5 / 12
GLY B 144
VAL B 159
SER B 173
LEU B 169
LEU B 184
1.21A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		7bv1 NSP7
NSP8
(SARS-CoV-2)		5 / 12
LEU C  55
SER C  54
LEU C  59
MET C  52
LEU D  95
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		7bv1 NSP12
(SARS-CoV-2)		4 / 4
LEU A 470
PRO A 296
ILE A 307
LEU A 308
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		7bv1 NSP7
NSP8
(SARS-CoV-2)		5 / 12
LEU C  55
SER C  54
LEU C  59
MET C  52
LEU D 103
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		7bv1 NSP7
(SARS-CoV-2)		5 / 12
LEU C  60
SER C  61
LEU C  56
MET C  62
LEU C  17
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		7bv1 NSP12
NSP8
(SARS-CoV-2)		4 / 8
MET A 380
LEU A 401
LEU A 673
PRO B 121
1.13A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_2
(CES1 PROTEIN)		7bv1 NSP12
(SARS-CoV-2)		4 / 4
LEU A 469
PRO A 461
ILE A 632
LEU A 630
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		7bv1 NSP12
(SARS-CoV-2)		4 / 8
PRO A 627
MET A 626
LEU A 460
PRO A 677
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		7bv1 NSP7
(SARS-CoV-2)		5 / 12
VAL C  16
LEU C  60
SER C  61
MET C  62
LEU C  20
1.37A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		7bv1 NSP7
(SARS-CoV-2)		6 / 12
GLY C  64
VAL C  22
LEU C  59
SER C  57
LEU C  17
LEU C  28
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		7bv1 NSP7
NSP8
(SARS-CoV-2)		5 / 12
PHE D  92
VAL C  22
LEU C  55
LEU C  60
LEU C  28
1.32A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		7bv1 NSP7
NSP8
(SARS-CoV-2)		5 / 12
PHE D  92
LEU C  55
LEU C  14
LEU C  60
LEU C  28
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		7bv1 NSP7
NSP8
(SARS-CoV-2)		4 / 4
LEU C  13
PRO D 116
ILE D 107
LEU D 103
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		7bv1 NSP12
NSP8
(SARS-CoV-2)		6 / 12
PHE A 407
GLY A 670
GLY A 671
LEU A 388
LEU A 401
MET B 129
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		7bv1 NSP12
NSP7
NSP8
(SARS-CoV-2)		5 / 12
PHE A 415
LEU C  55
LEU C  59
MET C  52
LEU D 103
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		7bv1 NSP12
(SARS-CoV-2)		4 / 4
LEU A 469
PRO A 461
ILE A 632
LEU A 630
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		7bv1 NSP12
NSP8
(SARS-CoV-2)		4 / 8
PRO A 378
MET A 380
LEU A 673
PRO B 121
1.47A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		7bv1 NSP7
NSP8
(SARS-CoV-2)		5 / 12
LEU C  55
SER C  54
LEU C  17
LEU D  98
LEU C  60
1.25A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		7bv1 NSP7
NSP8
(SARS-CoV-2)		5 / 12
PHE D  92
VAL C  22
LEU C  55
LEU C  60
LEU C  28
1.30A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		7bv1 NSP12
(SARS-CoV-2)		4 / 8
PRO A 243
MET A 242
GLY A 179
LEU A 131
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_2
(CES1 PROTEIN)		7bv1 NSP12
(SARS-CoV-2)		4 / 4
LEU A 470
PRO A 296
ILE A 307
LEU A 308
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
PHE A 368
VAL A 495
SER A 501
LEU A 498
LEU A 372
1.34A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		7bv1 NSP7
NSP8
(SARS-CoV-2)		5 / 12
ALA D 110
LEU C  60
SER C  61
MET C  62
LEU C  20
1.46A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		7bv1 NSP12
NSP7
NSP8
(SARS-CoV-2)		5 / 12
ALA A 443
LEU C  14
SER C  10
LEU C  17
LEU D  91
1.44A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_2
(CES1 PROTEIN)		7bv1 NSP7
NSP8
(SARS-CoV-2)		4 / 4
LEU C  59
PRO D 121
ILE D 106
LEU C  56
1.44A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		7bv1 NSP12
(SARS-CoV-2)		4 / 8
PRO A 243
MET A 463
LEU A 247
LEU A 131
1.80A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		7bv1 NSP12
NSP7
(SARS-CoV-2)		5 / 12
GLY A 841
GLY A 839
LEU A 437
SER C   4
LEU C  40
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_2
(CES1 PROTEIN)		7bv2 NSP12
(SARS-CoV-2)		4 / 4
LEU A 470
PRO A 296
ILE A 307
LEU A 308
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		7bv2 NSP12
NSP8
(SARS-CoV-2)		6 / 12
PHE A 407
GLY A 670
GLY A 671
LEU A 388
LEU A 401
MET B 129
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		7bv2 NSP8
(SARS-CoV-2)		5 / 12
GLY B 144
VAL B 186
SER B 173
LEU B 169
LEU B 184
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
PHE A 368
VAL A 495
SER A 501
LEU A 498
LEU A 372
1.44A
None
None
U  T   9 ( 2.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
PHE A 368
VAL A 495
SER A 501
LEU A 498
LEU A 372
1.44A
None
None
U  T   9 ( 2.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		7bv2 NSP12
NSP8
(SARS-CoV-2)		4 / 8
PRO A 378
MET A 380
LEU A 673
PRO B 121
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		7bv2 NSP12
NSP7
(SARS-CoV-2)		5 / 12
GLY A 841
GLY A 839
LEU A 437
SER C   4
LEU C  40
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		7bv2 NSP12
NSP8
(SARS-CoV-2)		5 / 12
GLY A 670
GLY A 671
LEU A 388
LEU A 401
MET B 129
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
PHE A 441
GLY A 839
GLY A 841
LEU A 862
SER A 861
1.48A
None
None
None
U  P  17 ( 4.9A)
U  P  17 ( 3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
ALA A 185
GLY A 179
LEU A 178
LEU A 241
LEU A 131
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
ALA A 866
PHE A 859
GLY A 841
GLY A 839
LEU A 883
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		7bv2 NSP12
NSP8
(SARS-CoV-2)		4 / 8
MET A 380
LEU A 401
LEU A 673
PRO B 121
1.20A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		7bv2 NSP8
(SARS-CoV-2)		5 / 12
GLY B 144
VAL B 159
SER B 173
LEU B 169
LEU B 184
1.31A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_2
(CES1 PROTEIN)		7bv2 NSP12
(SARS-CoV-2)		4 / 4
LEU A 883
PRO A 868
ILE A 837
LEU A 838
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		7bv2 NSP7
(SARS-CoV-2)		5 / 12
VAL C  16
LEU C  60
SER C  61
MET C  62
LEU C  20
1.39A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		7bv2 NSP12
(SARS-CoV-2)		4 / 4
LEU A 883
PRO A 868
ILE A 837
LEU A 838
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_2
(CES1 PROTEIN)		7bv2 NSP12
(SARS-CoV-2)		4 / 4
LEU A 469
PRO A 461
ILE A 632
LEU A 630
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		7bv2 NSP12
(SARS-CoV-2)		4 / 4
LEU A 469
PRO A 461
ILE A 632
LEU A 630
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		7bv2 NSP7
(SARS-CoV-2)		5 / 12
LEU C  60
SER C  61
LEU C  56
MET C  62
LEU C  17
1.44A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		7bv2 NSP12
(SARS-CoV-2)		4 / 4
LEU A 470
PRO A 296
ILE A 307
LEU A 308
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
ALA A 702
PHE A 694
SER A 784
LEU A 786
LEU A 247
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_2
(CES1 PROTEIN)		7bv2 NSP8
(SARS-CoV-2)		4 / 4
LEU B  98
PRO B 116
ILE B 107
LEU B 103
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		7bv2 NSP8
(SARS-CoV-2)		5 / 12
GLY B 144
VAL B 159
SER B 173
LEU B 169
LEU B 184
1.44A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
PHE A 441
GLY A 839
GLY A 841
LEU A 862
SER A 861
1.56A
None
None
None
U  P  17 ( 4.9A)
U  P  17 ( 3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
PHE A 859
GLY A 841
GLY A 839
LEU A 437
LEU A 883
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
PHE A 441
GLY A 839
GLY A 841
LEU A 862
SER A 861
1.51A
None
None
None
U  P  17 ( 4.9A)
U  P  17 ( 3.7A)