Ligand ID: CIA


Drugbank ID:
DB00820
(Tadalafil)


Indication:
Used for the treatment of erectile dysfunction.

Get human targets for CIA in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'CIA'

Click here for results that match SARS-Cov-2 / COVID-19 structures only
Click here for results that match SARS-related structures only


1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		1wnc E2 GLYCOPROTEIN
(SARSr-CoV)		5 / 12
ALA B 906
ILE B 905
GLN B 902
ILE B1179
GLN C 902
1.25A17.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		1wnc E2 GLYCOPROTEIN
(SARSr-CoV)		5 / 12
ALA B 906
ILE B 905
GLN B 902
ILE B1179
GLN C 902
1.33A16.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		1zv8 E2 GLYCOPROTEIN
(SARSr-CoV)		5 / 12
ALA G   6
ILE G   5
ILE L  31
ALA K  12
PHE I   9
1.44A15.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		2ahm REPLICASE
POLYPROTEIN 1AB,
HEAVY CHAIN
REPLICASE
POLYPROTEIN 1AB,
LIGHT CHAIN
(SARSr-CoV)		5 / 12
ALA G 115
ILE G 111
ILE C  73
VAL C  71
LEU C  22
1.32A19.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		2ahm REPLICASE
POLYPROTEIN 1AB,
HEAVY CHAIN
REPLICASE
POLYPROTEIN 1AB,
LIGHT CHAIN
(SARSr-CoV)		5 / 12
ALA G 115
ILE G 111
ILE C  73
VAL C  71
LEU C  22
1.29A19.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		2fe8 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
ILE A 286
ILE A 277
PHE A 305
LEU A 124
GLN A 123
1.31A22.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		2fe8 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
ILE A 286
ILE A 277
PHE A 305
LEU A 124
GLN A 123
1.24A23.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 12
ALA C 108
ILE C 107
ILE C  99
VAL C 121
ILE A 314
1.35A21.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 11
SER A  25
ILE E  42
VAL E  31
ALA E  30
ILE E  27
1.50A21.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		2rnk REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		6 / 12
ALA A 590
ILE A 592
ILE A 593
ALA A 631
LEU A 546
PHE A 581
1.79A17.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		3d0i ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 12
ALA B 576
GLN B 524
VAL B 573
ILE B 407
PHE B 400
1.36A21.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		3e9s NSP3
(SARSr-CoV)		5 / 12
ILE A 286
ILE A 277
PHE A 305
LEU A 124
GLN A 123
1.21A23.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		3e9s NSP3
(SARSr-CoV)		5 / 12
ILE A 286
ILE A 277
PHE A 305
LEU A 124
GLN A 123
1.26A21.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		3f9e 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
SER A  10
VAL A 157
PHE A 150
LEU A 115
MET A  17
1.56A22.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		3mj5 REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		5 / 12
ILE A 286
ILE A 277
PHE A 305
LEU A 124
GLN A 123
1.27A23.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		3sck ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 12
TYR A 381
ALA A 384
VAL A 404
PHE A 525
ILE A 544
1.36A21.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		4m0w REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		5 / 12
ILE A 286
ILE A 277
PHE A 305
LEU A 124
GLN A 123
1.24A23.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		4m0w REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		5 / 12
ILE A 286
ILE A 277
PHE A 305
LEU A 124
GLN A 123
1.31A21.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		4ovz PAPAIN-LIKE
PROTEINASE
(SARS-COV
Urbani)		5 / 12
ILE B 286
ILE B 277
PHE B 305
LEU B 124
GLN B 123
1.32A22.11
None
None
None
None
DMS  B 904 ( 4.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		4rna PAPAIN-LIKE PROTEASE
(Human
betacoronavirus
2c
EMC/2012)		5 / 11
SER A  85
ILE A 130
LEU A  86
ILE A 152
MET A 153
1.66A20.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		5c8s GUANINE-N7
METHYLTRANSFERASE
NSP10
(SARSr-CoV)		5 / 11
TYR D  64
ILE D 201
ALA C  18
LEU D   7
MET D  57
1.68A20.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		5c8s GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		5 / 12
ALA B  79
ILE B  80
ILE B 242
VAL B 244
PHE B 249
1.40A20.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		5c8u GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		5 / 12
ALA B 360
ILE D 338
VAL D 341
ALA D 344
LEU D 329
1.40A20.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		5c8u GUANINE-N7
METHYLTRANSFERASE
NSP10
(SARSr-CoV)		5 / 11
TYR D  64
ILE D 201
ALA C  18
LEU D   7
MET D  57
1.65A20.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		5e6j REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
ILE A 286
ILE A 277
PHE A 305
LEU A 124
GLN A 123
1.24A22.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		5e6j REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
ILE A 286
ILE A 277
PHE A 305
LEU A 124
GLN A 123
1.30A21.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		5f22 NSP8
NSP7
(SARSr-CoV)		5 / 12
ALA B 115
ILE B 111
ILE A  73
VAL A  71
LEU A  22
1.44A16.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		5 / 11
TYR A  64
ILE A 201
ALA M  18
LEU A   7
MET A  57
1.64A20.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		5 / 12
ALA C  79
ILE C 242
VAL C 244
PHE C 249
MET C 276
1.43A20.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		5 / 12
ALA A  79
ILE A  80
ILE A 242
VAL A 244
PHE A 249
1.50A20.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		5r82 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 11
SER A 267
ILE A 200
VAL A 204
ALA A 206
PHE A 230
1.25A23.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 11
ILE A 249
VAL A 202
ALA A 206
LEU A 268
MET A 264
1.65A19.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 11
SER A 267
ILE A 200
VAL A 204
ALA A 206
PHE A 230
1.31A19.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
ALA A   7
VAL A  13
PHE A 159
LEU A 177
MET A 162
1.71A19.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
ILE A 249
VAL A 202
ALA A 206
LEU A 268
MET A 264
1.66A19.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		5tl6 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
ILE B 286
ILE B 277
PHE B 305
LEU B 124
GLN B 123
1.23A23.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		5tl6 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
ILE B 286
ILE B 277
PHE B 305
LEU B 124
GLN B 123
1.29A22.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		5x58 SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 12
ALA B 658
ILE B 656
ILE B 584
VAL B 596
PHE B 629
1.36A15.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		5x58 SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 11
ILE B 345
VAL B 510
ALA B 508
LEU B 377
PHE B 501
1.51A14.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 12
ILE C 905
GLN C 908
VAL C1047
PHE C1034
PHE C 782
1.45A14.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		5x5c S PROTEIN
(MERS-CoV)		5 / 11
VAL A  50
ALA A 336
LEU A 321
ILE A 337
PHE A 341
1.57A13.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
ILE B 905
VAL B1047
PHE B1034
ILE B 913
PHE B 782
1.39A15.15
ILE  B 905 ( 0.7A)
VAL  B1047 ( 0.6A)
PHE  B1034 ( 1.3A)
ILE  B 913 ( 0.4A)
PHE  B 782 ( 1.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 11
ILE A 702
VAL A1047
PHE A1034
ILE A 913
PHE A 782
1.48A14.35
ILE  A 702 ( 0.7A)
VAL  A1047 ( 0.6A)
PHE  A1034 ( 1.3A)
ILE  A 913 ( 0.4A)
PHE  A 782 ( 1.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		5y3q REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		5 / 12
ILE A 286
ILE A 277
PHE A 305
LEU A 124
GLN A 123
1.25A23.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		5y3q REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		5 / 12
ILE A 286
ILE A 277
PHE A 305
LEU A 124
GLN A 123
1.29A22.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		5zvm PAN-COV INHIBITORY
PEPTIDE EK1
SPIKE GLYCOPROTEIN
(SARSr-CoV;
synthetic
construct)		5 / 12
ALA A 906
ILE A 905
ILE a  37
ALA B 912
PHE C 909
1.47A15.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6acg SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 11
ILE B 702
VAL B1047
PHE B1034
ILE B 916
PHE B 782
0.87A14.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6acg SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
ILE B 702
VAL B1047
PHE B1034
ILE B 916
PHE B 782
1.01A15.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6acj ACE2
(Homo
sapiens)		5 / 12
TYR D 381
ALA D 384
VAL D 404
PHE D 525
ILE D 544
1.38A21.46
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6ack SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
ALA A 406
ILE A 405
ILE A 397
VAL A 496
ALA A 422
1.08A14.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
ALA C 658
ILE C 650
ILE C 674
VAL C 594
LEU C 286
1.43A14.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6crx SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
ALA A 658
ILE A 650
ILE A 674
VAL A 594
LEU A 286
1.32A14.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6crx SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
ILE C 905
VAL C1047
PHE C1034
ILE C 913
PHE C 782
1.38A15.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6cs1 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 11
ILE A 702
VAL A1047
PHE A1034
ILE A 913
PHE A 782
1.52A14.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6jyt HELICASE
(SARSr-CoV)		5 / 12
ILE B 545
ILE B 512
PHE B 561
LEU B 581
MET B 576
1.44A19.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6jyt HELICASE
(SARSr-CoV)		5 / 11
SER A 264
ILE A 370
ALA A 292
PHE A 291
ILE A 293
1.12A19.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6lxt SPIKE PROTEIN S2
(SARS-CoV-2)		5 / 12
ALA E 924
ILE E 923
GLN E 920
LEU F1200
GLN F 920
1.48A18.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6lze VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
ALA A   7
VAL A  13
PHE A 159
LEU A 177
MET A 162
1.75A23.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6lze VIRAL PROTEASE
(SARS-CoV-2)		5 / 11
SER A 267
ILE A 200
VAL A 204
ALA A 206
PHE A 230
1.36A23.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6lze VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
ILE A 249
VAL A 202
ALA A 206
LEU A 268
MET A 264
1.65A23.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6lze VIRAL PROTEASE
(SARS-CoV-2)		5 / 11
ILE A 249
VAL A 202
ALA A 206
LEU A 268
MET A 264
1.66A23.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6lze VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
ILE A 106
PHE A 294
MET A   6
GLN A 127
PHE A   8
1.66A23.22
None
None
DMS  A 402 (-3.9A)
DMS  A 402 (-3.4A)
DMS  A 402 (-3.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6lze VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
TYR A 182
GLN A 110
ILE A 106
PHE A 134
ILE A 200
1.72A23.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6lzg ACE2
(Homo
sapiens)		5 / 12
TYR A 381
ALA A 384
VAL A 404
PHE A 525
ILE A 544
1.41A21.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
ILE A 249
VAL A 202
ALA A 206
LEU A 268
MET A 264
1.66A23.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		5 / 11
SER A 267
ILE A 200
VAL A 204
ALA A 206
PHE A 230
1.34A23.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
ALA A   7
VAL A  13
PHE A 159
LEU A 177
MET A 162
1.74A23.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
ILE A 106
PHE A 294
MET A   6
GLN A 127
PHE A   8
1.65A23.16
None
None
DMS  A 404 (-3.9A)
DMS  A 404 (-3.3A)
DMS  A 404 (-3.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		5 / 11
ILE A 249
VAL A 202
ALA A 206
LEU A 268
MET A 264
1.66A23.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6m17 ACE2
(Homo
sapiens)		5 / 11
SER D 646
VAL B 647
ALA B 650
LEU D 642
PHE B 715
1.44A17.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6m1d SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 12
ALA A 406
ILE A 407
LEU A 234
ILE A 236
PHE A 420
1.11A19.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6m1d SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 11
SER C 118
ILE C 588
VAL C 592
ALA C 590
PHE C 123
1.58A17.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 11
SER D 267
ILE D 200
VAL D 204
ALA D 206
PHE D 230
1.31A23.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ALA B   7
VAL B  13
PHE B 159
LEU B 177
MET B 162
1.77A23.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ILE C 249
VAL C 202
ALA C 206
LEU C 268
MET C 264
1.67A23.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ALA D   7
VAL D  13
PHE D 159
LEU D 177
MET D 162
1.75A23.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 11
ILE C 249
VAL C 202
ALA C 206
LEU C 268
MET C 264
1.67A23.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 11
ILE A 249
VAL A 202
ALA A 206
LEU A 268
MET A 264
1.73A23.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 11
SER A 267
ILE A 200
VAL A 204
ALA A 206
PHE A 230
1.63A23.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ILE B 249
VAL B 202
ALA B 206
LEU B 268
MET B 264
1.74A23.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
TYR A 182
GLN A 110
ILE A 106
PHE A 134
ILE A 200
1.72A23.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 11
SER C 267
ILE C 200
VAL C 204
ALA C 206
PHE C 230
1.48A23.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ALA C   7
VAL C  13
PHE C 159
LEU C 177
MET C 162
1.75A23.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ILE B 106
PHE B 294
MET B   6
GLN B 127
PHE B   8
1.74A23.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ILE A 249
VAL A 202
ALA A 206
LEU A 268
MET A 264
1.73A23.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 11
ILE D 249
VAL D 202
ALA D 206
LEU D 268
MET D 264
1.67A23.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
TYR B 182
GLN B 110
ILE B 106
PHE B 134
ILE B 200
1.67A23.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ALA A   7
VAL A  13
PHE A 159
LEU A 177
MET A 162
1.76A23.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ILE D 249
VAL D 202
ALA D 206
LEU D 268
MET D 264
1.67A23.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 11
SER B 267
ILE B 200
VAL B 204
ALA B 206
PHE B 230
1.62A23.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6m2q 3CL PROTEASE
(SARS-CoV-2)		5 / 11
ILE A 249
VAL A 202
ALA A 206
LEU A 268
MET A 264
1.66A23.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6m2q 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ALA A   7
VAL A  13
PHE A 159
LEU A 177
MET A 162
1.75A23.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6m2q 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ILE A 249
VAL A 202
ALA A 206
LEU A 268
MET A 264
1.66A23.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6m2q 3CL PROTEASE
(SARS-CoV-2)		5 / 11
SER A 267
ILE A 200
VAL A 204
ALA A 206
PHE A 230
1.31A23.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6m71 NSP7
NSP8
(SARS-CoV-2)		5 / 12
ILE D 119
ILE D 120
VAL C  53
LEU C  13
ILE C  39
1.80A19.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6m71 NSP12
(SARS-CoV-2)		5 / 11
SER A 672
ALA A 383
LEU A 673
MET A 666
PHE A 504
1.74A15.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6m71 NSP12
(SARS-CoV-2)		5 / 11
TYR A 770
VAL A 776
ALA A 777
LEU A 749
MET A 755
1.79A15.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6m71 NSP12
(SARS-CoV-2)		5 / 12
ALA A 195
ILE A 201
VAL A  96
ALA A  97
PHE A 222
1.76A15.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6m71 NSP12
(SARS-CoV-2)		5 / 12
ALA A 699
GLN A 698
VAL A 472
LEU A 308
MET A 629
1.66A15.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6m71 NSP12
(SARS-CoV-2)		5 / 11
SER A 672
ALA A 379
LEU A 673
MET A 666
PHE A 504
1.64A15.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6m71 NSP12
(SARS-CoV-2)		5 / 12
ALA A 625
LEU A 469
ILE A 632
MET A 633
PHE A 694
1.71A17.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6m71 NSP12
(SARS-CoV-2)		5 / 12
TYR A 479
ALA A 699
VAL A 476
PHE A 480
LEU A 638
1.50A15.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6m71 NSP12
(SARS-CoV-2)		5 / 12
ALA A 699
GLN A 698
VAL A 472
LEU A 308
MET A 629
1.66A17.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6m71 NSP12
NSP7
(SARS-CoV-2)		5 / 11
SER C   4
ALA A 840
PHE A 843
LEU A 437
ILE A 837
1.65A15.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6m71 NSP7
NSP8
(SARS-CoV-2)		5 / 12
ALA D 110
ILE D 107
ILE C  68
VAL C  66
MET D  90
1.73A19.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6m71 NSP12
(SARS-CoV-2)		5 / 12
ALA A 699
GLN A 698
VAL A 476
PHE A 480
LEU A 638
1.70A15.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
ALA B 658
ILE B 650
ILE B 674
VAL B 594
LEU B 286
1.40A13.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
ILE C 905
VAL C1047
PHE C1034
ILE C 913
PHE C 782
1.41A14.96
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6nb7 SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 11
ILE B 702
VAL B1047
PHE B1034
ILE B 913
PHE B 880
1.52A13.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6nur NSP12
NSP8
(SARSr-CoV)		5 / 12
TYR A 515
ALA A 502
ILE A 562
LEU B  91
MET A 380
1.41A16.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6nur NSP7
NSP8
(SARSr-CoV)		5 / 11
SER C  57
VAL C  66
ALA C  65
GLN D  88
PHE D  92
1.60A15.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6nus NSP12
(SARSr-CoV)		5 / 11
SER A 672
ALA A 379
LEU A 673
MET A 666
PHE A 504
1.42A15.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 11
SER C 297
ILE C 312
VAL C 597
ALA C 609
LEU C 296
1.46A13.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ILE B 923
GLN B 926
VAL B1065
PHE B1052
PHE B 800
1.44A13.99
None
NAG  B1307 ( 4.5A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ILE B 923
VAL B1065
PHE B1052
ILE B 931
PHE B 800
1.40A15.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6vxs NSP3
(SARS-CoV-2)		5 / 12
ALA B 154
ILE B  23
VAL B 151
PHE B 116
LEU B  93
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6vxs NSP3
(SARS-CoV-2)		5 / 12
ALA A 154
ILE A  23
VAL A 151
PHE A 116
LEU A  93
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ILE C 923
GLN C 926
VAL C1065
PHE C1052
PHE C 800
1.33A13.78
None
NAG  C1312 ( 4.9A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ILE B 923
VAL B1065
PHE B1052
ILE B 931
PHE B 800
1.37A15.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ILE A 923
GLN A 926
VAL A1065
PHE A1052
PHE A 800
1.36A13.78
None
NAG  A1312 ( 4.9A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ILE C 923
VAL C1065
PHE C1052
ILE C 931
PHE C 800
1.39A15.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		5 / 12
ALA C 397
ILE C 358
VAL C 524
LEU C 390
PHE C 515
1.76A18.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
ILE A6866
ILE A6951
VAL A6965
ALA A6966
LEU A6857
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
ILE A6925
ILE A6926
ALA A6870
LEU A6909
PHE A6954
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 11
SER A 267
ILE A 200
VAL A 204
ALA A 206
PHE A 230
1.31A23.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 11
ILE A 249
VAL A 202
ALA A 206
LEU A 268
MET A 264
1.63A23.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
ILE A 249
VAL A 202
ALA A 206
LEU A 268
MET A 264
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
ALA A   7
VAL A  13
PHE A 159
LEU A 177
MET A 162
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6w6y NSP3
(SARS-CoV-2)		5 / 11
TYR B 161
SER A 166
ILE B  18
ALA B  21
LEU A 169
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6w6y NSP3
(SARS-CoV-2)		5 / 12
ALA A 154
ILE A  23
VAL A 151
PHE A 116
LEU A  93
1.66A
AMP  A 201 ( 4.5A)
AMP  A 201 ( 4.0A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6w6y NSP3
(SARS-CoV-2)		5 / 12
ALA B 154
ILE B  23
VAL B 151
PHE B 116
LEU B  93
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6w75 NSP16
(SARS-CoV-2)		5 / 12
ILE A6925
ILE A6926
ALA A6870
LEU A6909
PHE A6954
1.66A17.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6w75 NSP16
(SARS-CoV-2)		5 / 12
ILE C6925
ILE C6926
ALA C6870
LEU C6909
PHE C6954
1.67A17.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6w75 NSP16
(SARS-CoV-2)		5 / 12
ILE A6866
ILE A6951
VAL A6965
ALA A6966
LEU A6857
1.71A17.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6wcf NSP3
(SARS-CoV-2)		5 / 12
ALA A 154
ILE A  23
VAL A 151
PHE A 116
LEU A  93
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6wen NSP3
(SARS-CoV-2)		5 / 12
ALA A 154
ILE A  23
VAL A 151
PHE A 116
LEU A  93
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6wen NSP3
(SARS-CoV-2)		5 / 12
ALA A 154
ILE A  23
VAL A 151
PHE A 116
LEU A  93
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6wey NSP3
(SARS-CoV-2)		5 / 12
ALA A 231
ILE A 227
VAL A 240
PHE A 320
LEU A 331
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6wey NSP3
(SARS-CoV-2)		5 / 12
ALA A 358
ILE A 227
VAL A 355
PHE A 320
LEU A 297
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6wey NSP3
(SARS-CoV-2)		5 / 12
ALA A 358
ILE A 227
VAL A 355
PHE A 320
LEU A 297
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
ILE A6866
ILE A6951
VAL A6965
ALA A6966
LEU A6857
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
ILE A6925
ILE A6926
ALA A6870
LEU A6909
PHE A6954
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
ILE C6925
ILE C6926
ALA C6870
LEU C6909
PHE C6954
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
GLN C  83
ILE C  84
VAL C 133
LEU C  56
PHE C  53
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
ILE C 146
ILE C  84
VAL C  72
LEU C 159
ILE C  74
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
GLN D  83
ILE D  84
VAL D 133
LEU D  56
PHE D  53
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
GLN C  83
ILE C  84
VAL C 133
LEU C  56
PHE C  53
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
GLN B  83
ILE B  84
VAL B 133
LEU B  56
PHE B  53
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6wkq NSP16
(SARS-CoV-2)		5 / 12
ILE C6925
ILE C6926
ALA C6870
LEU C6909
PHE C6954
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6wkq NSP16
(SARS-CoV-2)		5 / 12
ILE A6866
ILE A6951
VAL A6965
ALA A6966
LEU A6857
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6wkq NSP16
(SARS-CoV-2)		5 / 12
ILE A6925
ILE A6926
ALA A6870
LEU A6909
PHE A6954
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
ILE A 249
VAL A 202
ALA A 206
LEU A 268
MET A 264
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 11
SER A 267
ILE A 200
VAL A 204
ALA A 206
PHE A 230
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
ALA A   7
VAL A  13
PHE A 159
LEU A 177
MET A 162
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 11
ILE A 249
VAL A 202
ALA A 206
LEU A 268
MET A 264
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
ALA B 154
ILE B  23
VAL B 151
PHE B 116
LEU B  93
1.64A
APR  B 201 (-4.6A)
APR  B 201 (-3.8A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
ALA A 154
ILE A  23
VAL A 151
PHE A 116
LEU A  93
1.66A
APR  A 201 (-4.6A)
APR  A 201 (-4.0A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
ALA D 154
ILE D  23
VAL D 151
PHE D 116
LEU D  93
1.62A
APR  D 201 (-4.4A)
APR  D 201 (-3.8A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
ALA C 154
ILE C  23
VAL C 151
PHE C 116
LEU C  93
1.67A
APR  C 201 (-4.5A)
APR  C 201 (-3.9A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
ILE A6866
ILE A6951
VAL A6965
ALA A6966
LEU A6857
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
ILE A6925
ILE A6926
ALA A6870
LEU A6909
PHE A6954
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6wqd NSP7
NSP8
(SARS-CoV-2)		5 / 12
ALA D  81
GLN C  19
ALA C  65
LEU C  71
GLN D  88
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
ILE A 249
VAL A 202
ALA A 206
LEU A 268
MET A 264
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 11
ILE A 249
VAL A 202
ALA A 206
LEU A 268
MET A 264
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 11
SER A 267
ILE A 200
VAL A 204
ALA A 206
PHE A 230
1.32A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 11
ILE A 249
VAL A 202
ALA A 206
LEU A 268
MET A 264
1.65A19.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 11
SER A 267
ILE A 200
VAL A 204
ALA A 206
PHE A 230
1.32A19.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
ALA A   7
VAL A  13
PHE A 159
LEU A 177
MET A 162
1.71A19.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
ILE A 249
VAL A 202
ALA A 206
LEU A 268
MET A 264
1.66A19.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6yi3 NUCLEOPROTEIN
(SARS-CoV-2)		5 / 12
ALA A  98
GLN A  43
LEU A 119
ILE A  34
PHE A  70
1.80A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6ym0 LIGHT CHAIN
(Homo
sapiens)		5 / 12
ALA L  86
ILE L 112
VAL L 110
LEU L  79
PHE L  68
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
ALA A   7
VAL A  13
PHE A 159
LEU A 177
MET A 162
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
ILE A 249
VAL A 202
ALA A 206
LEU A 268
MET A 264
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 11
SER A 267
ILE A 200
VAL A 204
ALA A 206
PHE A 230
1.32A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 11
ILE A 249
VAL A 202
ALA A 206
LEU A 268
MET A 264
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
ALA A   7
VAL A  13
PHE A 159
LEU A 177
MET A 162
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
ILE A 249
VAL A 202
ALA A 206
LEU A 268
MET A 264
1.68A
None
PEG  A 405 (-4.1A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 11
SER A 267
ILE A 200
VAL A 204
ALA A 206
PHE A 230
1.35A
None
PEG  A 405 (-4.1A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ALA B 154
ILE B  23
VAL B 151
PHE B 116
LEU B  93
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ALA A 154
ILE A  23
VAL A 151
PHE A 116
LEU A  93
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ALA C 154
ILE C  23
VAL C 151
PHE C 116
LEU C  93
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ALA C 154
ILE C  23
VAL C 151
PHE C 116
LEU C  93
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ALA D 154
ILE D  23
VAL D 151
PHE D 116
LEU D  93
1.67A
EDO  D 208 (-4.2A)
EDO  D 208 (-4.0A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ALA E 154
ILE E  23
VAL E 151
PHE E 116
LEU E  93
1.59A
EDO  E 205 (-4.4A)
EDO  E 205 (-4.2A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ALA E 154
ILE E  23
VAL E 151
PHE E 116
LEU E  93
1.73A
EDO  E 205 (-4.4A)
EDO  E 205 (-4.2A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ALA C 154
ILE C  23
VAL C 151
PHE C 116
LEU C  93
1.78A
APR  C 201 (-4.5A)
APR  C 201 (-3.9A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ALA A 154
ILE A  23
VAL A 151
PHE A 116
LEU A  93
1.64A
APR  A 201 (-4.4A)
APR  A 201 (-3.9A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ALA D 154
ILE D  23
VAL D 151
PHE D 116
LEU D  93
1.68A
APR  D 201 (-4.5A)
APR  D 201 (-3.9A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ALA C 154
ILE C  23
VAL C 151
PHE C 116
LEU C  93
1.63A
APR  C 201 (-4.5A)
APR  C 201 (-3.9A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ALA E 154
ILE E  23
VAL E 151
PHE E 116
LEU E  93
1.78A
APR  E 201 (-4.5A)
APR  E 201 (-4.1A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ALA B 154
ILE B  23
VAL B 151
PHE B 116
LEU B  93
1.63A
APR  B 201 (-4.5A)
APR  B 201 (-4.1A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ALA E 154
ILE E  23
VAL E 151
PHE E 116
LEU E  93
1.63A
APR  E 201 (-4.5A)
APR  E 201 (-4.1A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ALA C 154
ILE C  23
VAL C 151
PHE C 116
LEU C  93
1.69A
EDO  C 206 (-4.4A)
EDO  C 206 (-4.1A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ALA A 154
ILE A  23
VAL A 151
PHE A 116
LEU A  93
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ALA B 154
ILE B  23
VAL B 151
PHE B 116
LEU B  93
1.66A
EDO  B 202 (-4.3A)
EDO  B 202 (-4.0A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		7bqy MAIN PROTEASE
(SARS-CoV-2)		5 / 11
ILE A 249
VAL A 202
ALA A 206
LEU A 268
MET A 264
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		7bqy MAIN PROTEASE
(SARS-CoV-2)		5 / 12
ALA A   7
VAL A  13
PHE A 159
LEU A 177
MET A 162
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		7bqy MAIN PROTEASE
(SARS-CoV-2)		5 / 11
SER A 267
ILE A 200
VAL A 204
ALA A 206
PHE A 230
1.37A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		7bqy MAIN PROTEASE
(SARS-CoV-2)		5 / 12
ILE A 249
VAL A 202
ALA A 206
LEU A 268
MET A 264
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		7btf NSP12
NSP7
(SARS-CoV-2)		5 / 11
SER C   4
ALA A 840
PHE A 843
LEU A 437
ILE A 837
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		7btf NSP12
(SARS-CoV-2)		5 / 12
ALA A 699
GLN A 698
VAL A 472
LEU A 308
MET A 629
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		7btf NSP12
(SARS-CoV-2)		5 / 12
ALA A 699
GLN A 698
VAL A 472
LEU A 308
MET A 629
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		7btf NSP12
(SARS-CoV-2)		5 / 12
ALA A 625
LEU A 469
ILE A 632
MET A 633
PHE A 694
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		7btf NSP12
(SARS-CoV-2)		5 / 11
SER A 672
ALA A 383
LEU A 673
MET A 666
PHE A 504
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		7btf NSP12
(SARS-CoV-2)		5 / 11
SER A 672
ALA A 379
LEU A 673
MET A 666
PHE A 504
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		5 / 11
ILE A 249
VAL A 202
ALA A 206
LEU A 268
MET A 264
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		5 / 12
ILE A 249
VAL A 202
ALA A 206
LEU A 268
MET A 264
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		5 / 11
SER A 267
ILE A 200
VAL A 204
ALA A 206
PHE A 230
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		5 / 12
ILE A 106
PHE A 294
MET A   6
GLN A 127
PHE A   8
1.64A
None
None
DMS  A 406 (-3.6A)
DMS  A 406 (-3.3A)
DMS  A 406 (-3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		5 / 12
ALA A   7
VAL A  13
PHE A 159
LEU A 177
MET A 162
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
ALA A 699
GLN A 698
VAL A 476
PHE A 480
LEU A 638
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		7bv1 NSP12
(SARS-CoV-2)		5 / 11
SER A 672
ALA A 383
LEU A 673
MET A 666
PHE A 504
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		7bv1 NSP12
NSP7
(SARS-CoV-2)		5 / 11
SER C   4
ALA A 840
PHE A 843
LEU A 437
ILE A 837
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		7bv1 NSP7
NSP8
(SARS-CoV-2)		5 / 12
ALA D 150
ILE D 106
ILE D 120
LEU C  17
MET C  62
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
ALA A 195
ILE A 201
VAL A  96
ALA A  97
PHE A 222
1.80A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		7bv1 NSP7
NSP8
(SARS-CoV-2)		5 / 12
ALA D 150
ILE D 106
ILE D 120
LEU C  17
MET C  62
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		7bv1 NSP12
NSP8
(SARS-CoV-2)		5 / 12
TYR A 515
ALA A 502
ILE A 562
LEU B  91
MET A 380
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
TYR A 479
ALA A 699
VAL A 476
PHE A 480
LEU A 638
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
TYR A 479
ALA A 699
VAL A 476
PHE A 480
LEU A 638
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
ALA A 699
GLN A 698
VAL A 472
LEU A 308
MET A 629
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		7bv1 NSP12
(SARS-CoV-2)		5 / 11
SER A 672
ALA A 379
LEU A 673
MET A 666
PHE A 504
1.44A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		7bv1 NSP12
NSP8
(SARS-CoV-2)		5 / 12
TYR A 515
ALA A 502
ILE A 562
LEU B  91
MET A 380
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
ALA A 699
GLN A 698
VAL A 472
LEU A 308
MET A 629
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		7bv2 NSP12
NSP7
(SARS-CoV-2)		5 / 11
SER C   4
ALA A 840
PHE A 843
LEU A 437
ILE A 837
1.74A
None
U  P  18 ( 3.4A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
ALA A 699
GLN A 698
VAL A 472
LEU A 308
MET A 629
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		7bv2 NSP12
(SARS-CoV-2)		5 / 11
SER A 835
VAL A 424
PHE A 429
LEU A 437
PHE A 419
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		7bv2 NSP12
NSP8
(SARS-CoV-2)		5 / 12
TYR A 515
ALA A 502
ILE A 562
LEU B  91
MET A 380
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		7bv2 NSP12
(SARS-CoV-2)		5 / 11
SER A 672
ALA A 383
LEU A 673
MET A 666
PHE A 504
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
TYR A 479
ALA A 699
VAL A 476
PHE A 480
LEU A 638
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		7bv2 NSP12
(SARS-CoV-2)		5 / 11
SER A 672
ALA A 379
LEU A 673
MET A 666
PHE A 504
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
ALA A 699
GLN A 698
VAL A 472
LEU A 308
MET A 629
1.70A
None