Ligand ID: BHA


Drugbank ID:
DB00233
(Aminosalicylic Acid)


Indication:
For the treatment of tuberculosis

Get human targets for BHA in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'BHA'

Click here for results that match SARS-Cov-2 / COVID-19 structures only
Click here for results that match SARS-related structures only


1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		1q2w 3C-LIKE PROTEASE
(SARSr-CoV)		4 / 6
LEU B 262
VAL B 261
LEU B 205
VAL B 247
1.35A20.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		2a5k 3C-LIKE PEPTIDASE
(SARSr-CoV)		4 / 6
LEU B 262
VAL B 261
LEU B 205
VAL B 247
1.36A20.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		2acf REPLICASE
POLYPROTEIN 1AB
(SARS-COV
Tor2)		4 / 6
LEU A 253
VAL D 347
LEU D 194
VAL D 346
1.29A24.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		2acf REPLICASE
POLYPROTEIN 1AB
(SARS-COV
Tor2)		5 / 10
GLY D 261
VAL D 277
LEU D 275
TYR D 250
ALA D 221
1.39A19.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBF_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		2acf REPLICASE
POLYPROTEIN 1AB
(SARS-COV
Tor2)		5 / 9
VAL C 277
LEU C 309
TYR C 295
LEU C 291
SER C 310
1.74A19.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		2ajf ACE2
(Homo
sapiens)		5 / 10
GLY B 405
VAL B 404
LEU B 554
LEU B 529
ALA B 403
1.42A20.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		2d2d 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
LEU A 262
VAL A 261
LEU A 205
VAL A 247
1.35A20.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBF_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		2fav REPLICASE
POLYPROTEIN 1AB
(PP1AB) (ORF1AB)
(SARSr-CoV)		5 / 9
VAL A  96
LEU A 128
TYR A 114
LEU A 110
SER A 129
1.79A20.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		2fav REPLICASE
POLYPROTEIN 1AB
(PP1AB) (ORF1AB)
(SARSr-CoV)		5 / 10
GLY C  80
VAL C  96
LEU C  94
TYR C  69
ALA C  40
1.42A20.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		2ghw ANTI-SCFV ANTIBODY,
80R
(Homo
sapiens)		5 / 10
GLY B 173
TRP B 107
TYR B 219
LEU B  45
TYR B  95
1.57A21.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		2k7x REPLICASE
POLYPROTEIN 1AB MAIN
PROTEASE
(SARS-COV
Sino1-11)		4 / 6
LEU A 262
VAL A 261
LEU A 205
VAL A 247
1.36A18.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		2kaf NSP3
(SARSr-CoV)		4 / 6
LEU A  62
VAL A  40
LEU A  52
ARG A  35
1.19A17.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		2kqw NSP3
(SARSr-CoV)		4 / 6
LEU A 193
VAL A 171
LEU A 183
ARG A 166
1.23A22.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		2kys NSP7
(SARSr-CoV)		4 / 6
LEU A  57
LEU A  62
ARG A  72
VAL A  18
1.09A22.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		2pwx 3C-LIKE PROTEINASE
(SARS-COV
BJ01)		4 / 6
LEU A 262
VAL A 261
LEU A 205
VAL A 247
1.35A20.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		2q6g REPLICASE
POLYPROTEIN 1AB
(SARS-COV
BJ01)		4 / 6
LEU A 262
VAL A 261
LEU A 205
VAL A 247
1.33A21.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		3d0g ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 10
GLY B 405
VAL B 404
LEU B 554
LEU B 529
ALA B 403
1.40A20.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBF_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		3d0h ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 9
VAL A 573
LEU A 558
TYR A 381
ARG A 559
ALA A 569
1.74A20.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		3f9g 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
LEU A 262
VAL A 261
LEU A 205
VAL A 247
1.36A20.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		3f9h 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
LEU B 262
VAL B 261
LEU B 205
VAL B 247
1.29A19.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		3iwm 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
LEU B 262
VAL B 261
LEU D 205
VAL B 247
1.27A20.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		3m3s 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
LEU A 262
VAL A 261
LEU A 205
VAL A 247
1.35A21.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		3m3v 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
LEU A 262
VAL A 261
LEU A 205
VAL A 247
1.35A20.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		3scl ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 10
GLY A 405
VAL A 404
LEU A 554
LEU A 529
ALA A 403
1.44A21.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBF_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		3vb4 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
LEU B 141
TYR B 118
SER A 301
ARG A 298
ALA B 116
1.74A20.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		4hi3 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
LEU A 262
VAL A 261
LEU A 205
VAL A 247
1.38A20.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		4rna PAPAIN-LIKE PROTEASE
(Human
betacoronavirus
2c
EMC/2012)		5 / 10
VAL A  90
LEU A 104
LEU A 113
TYR A 112
ALA A 150
1.64A20.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBF_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		4rna PAPAIN-LIKE PROTEASE
(Human
betacoronavirus
2c
EMC/2012)		5 / 9
TRP A  93
LEU A 169
TYR A 112
LEU A 113
ALA A 162
1.54A20.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		5b6o 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
LEU A  75
ARG A  76
VAL A  91
VAL A  36
1.36A20.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		5c5o 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 6
LEU B 262
VAL B 261
LEU B 205
VAL B 247
1.35A20.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		5c8u GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		4 / 6
LEU B 253
VAL B 244
ARG B 278
VAL B 184
1.23A14.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 6
ARG A  40
VAL A  42
LEU A  87
VAL A  20
1.57A17.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 6
LEU A 115
VAL A  13
LEU A  30
VAL A 157
1.76A17.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 6
LEU A  75
ARG A  76
VAL A  91
VAL A  36
1.54A17.58
None
DMS  A 401 (-3.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 6
LEU A 262
VAL A 261
LEU A 205
VAL A 247
1.34A17.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 6
LEU A  89
VAL A  68
LEU A  75
VAL A  20
1.77A17.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 6
LEU A  89
VAL A  68
LEU A  75
VAL A  18
1.42A17.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		5tl6 UBIQUITIN-LIKE
PROTEIN ISG15
(Homo
sapiens)		4 / 6
LEU A 124
VAL A 148
LEU A 142
VAL A  86
1.36A19.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		5tl7 UBIQUITIN-LIKE
PROTEIN ISG15
(Mus
musculus)		4 / 6
LEU A 122
VAL A 146
LEU A 140
VAL A  84
1.36A19.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		5wrg SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 10
GLY B 839
VAL B 718
LEU B 986
TYR B 989
LEU B 944
1.46A15.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		5x4r S PROTEIN
(MERS-CoV)		4 / 6
ARG A 190
LEU A 234
ARG A 181
VAL A 170
1.32A19.16
None
None
NAG  A 503 (-3.8A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		5x59 S PROTEIN
(MERS-CoV)		4 / 6
ARG B 190
LEU B 234
ARG B 181
VAL B 170
1.31A8.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 10
GLY B 839
VAL B 718
LEU B 986
TYR B 989
LEU B 944
1.44A15.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		5zvm PAN-COV INHIBITORY
PEPTIDE EK1
SPIKE GLYCOPROTEIN
(SARSr-CoV;
synthetic
construct)		4 / 6
LEU B 930
VAL B 934
LEU b  16
VAL C 934
1.29A20.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6ack SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 10
GLY A 839
VAL A 718
LEU A 986
TYR A 989
LEU A 944
1.27A15.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6ack SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 6
LEU C 804
VAL C1043
LEU C1045
VAL C 708
1.19A9.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 10
GLY C 839
VAL C 718
LEU C 986
TYR C 989
LEU C 944
1.48A15.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6crz SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 6
LEU B 804
VAL B1043
LEU B1045
VAL B 708
1.23A9.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBF_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6cs2 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 9
LEU B 374
TYR B 352
LEU B 355
SER B 353
ALA B 350
1.78A15.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6cs2 ACE2
(Homo
sapiens)		5 / 10
GLY D 405
VAL D 404
LEU D 554
LEU D 529
ALA D 403
1.43A20.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6cs2 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 10
GLY C 839
VAL C 718
LEU C 986
TYR C 989
LEU C 944
1.34A15.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBF_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6jyt HELICASE
(SARSr-CoV)		5 / 9
LEU A 240
TYR A 277
LEU A 428
SER A 424
ARG A 427
1.63A22.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6jyt HELICASE
(SARSr-CoV)		4 / 6
LEU A 280
VAL A 397
LEU A 295
VAL A 372
1.38A15.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6lxt SPIKE PROTEIN S2
(SARS-CoV-2)		5 / 6
LEU B 984
ARG C 983
VAL B 987
ARG A 983
VAL A 987
1.66A21.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6lze VIRAL PROTEASE
(SARS-CoV-2)		4 / 6
LEU A 262
VAL A 261
LEU A 205
VAL A 247
1.32A20.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6m03 MAIN PROTEASE
(SARS-CoV-2)		4 / 6
LEU A 262
VAL A 261
LEU A 205
VAL A 247
1.31A20.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6m0j ACE2
(Homo
sapiens)		5 / 10
GLY A 405
VAL A 404
LEU A 554
LEU A 529
ALA A 403
1.35A21.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		4 / 6
LEU A 262
VAL A 261
LEU A 205
VAL A 247
1.33A20.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBF_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6m1d ACE2
(Homo
sapiens)		5 / 9
VAL D 447
TRP D 594
LEU D 236
LEU D 595
ALA D 443
1.72A17.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6m1d SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		4 / 6
LEU A 558
VAL A 586
LEU A 484
VAL A 582
1.38A14.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 6
LEU B 262
VAL B 261
LEU B 205
VAL B 247
1.30A20.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 6
LEU A  89
VAL A  68
LEU A  75
VAL A  18
1.47A20.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 6
LEU B  89
VAL B  68
LEU B  75
VAL B  18
1.44A20.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 6
LEU A  75
ARG A  76
VAL A  91
VAL A  36
1.45A20.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 6
LEU A 262
VAL A 261
LEU A 205
VAL A 247
1.36A20.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 6
LEU C  75
ARG C  76
VAL C  91
VAL C  36
1.51A20.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 6
LEU D 262
VAL D 261
LEU D 205
VAL D 247
1.38A20.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 6
LEU D  75
ARG D  76
VAL D  91
VAL D  36
1.60A20.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 6
LEU C 262
VAL C 261
LEU C 205
VAL C 247
1.47A20.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6m2q 3CL PROTEASE
(SARS-CoV-2)		4 / 6
ARG A  40
VAL A  42
LEU A  87
VAL A  20
1.60A20.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6m2q 3CL PROTEASE
(SARS-CoV-2)		4 / 6
LEU A 262
VAL A 261
LEU A 205
VAL A 247
1.31A20.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6m2q 3CL PROTEASE
(SARS-CoV-2)		4 / 6
LEU A  75
ARG A  76
VAL A  91
VAL A  36
1.57A20.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6m2q 3CL PROTEASE
(SARS-CoV-2)		4 / 6
LEU A  89
VAL A  68
LEU A  75
VAL A  18
1.44A20.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6m71 NSP12
(SARS-CoV-2)		5 / 10
GLY A 179
VAL A 182
LEU A 245
TYR A 286
ALA A 185
1.66A17.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6m71 NSP12
(SARS-CoV-2)		4 / 6
LEU A 241
ARG A 132
LEU A 131
VAL A 182
1.60A10.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6m71 NSP12
(SARS-CoV-2)		4 / 6
ARG A 750
VAL A 475
LEU A 749
VAL A 472
1.47A10.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6nb7 SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 10
GLY A 839
VAL A 718
LEU A 986
TYR A 989
LEU A 944
1.50A15.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6nb8 S230 ANTIGEN-BINDING
(FAB) FRAGMENT,
HEAVY CHAIN
(Homo
sapiens)		4 / 6
LEU H 173
VAL H 196
LEU H 152
VAL H 198
1.36A19.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 10
GLY A 857
VAL A 736
LEU A1004
TYR A1007
LEU A 962
1.43A14.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6vxs NSP3
(SARS-CoV-2)		5 / 10
GLY B  79
VAL B  95
LEU B  93
TYR B  68
ALA B  39
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6vxs NSP3
(SARS-CoV-2)		4 / 6
LEU B 153
VAL B 151
LEU B 122
VAL B 147
1.23A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6vxs NSP3
(SARS-CoV-2)		4 / 6
LEU B  12
VAL B  16
LEU B 153
VAL B 144
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6vxs NSP3
(SARS-CoV-2)		4 / 6
LEU A 153
VAL A 151
LEU A 122
VAL A 147
1.21A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6vxs NSP3
(SARS-CoV-2)		4 / 6
LEU A  12
VAL A  16
LEU A 153
VAL A 144
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6vxs NSP3
(SARS-CoV-2)		5 / 10
VAL B  95
LEU B 127
TYR B 113
LEU B 109
SER B 128
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 6
LEU A 141
VAL A 120
LEU A 118
VAL A 127
1.34A8.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6w02 NSP3
(SARS-CoV-2)		4 / 6
LEU B 153
VAL B 151
LEU B 122
VAL B 147
1.17A20.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6w02 NSP3
(SARS-CoV-2)		5 / 10
GLY A  79
VAL A  95
LEU A  93
TYR A  68
ALA A  39
1.44A19.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6w41 CR3022 FAB HEAVY
CHAIN
(Homo
sapiens)		4 / 6
VAL H 111
LEU H  82
ARG H  38
VAL H 109
1.80A21.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6w41 CR3022 FAB HEAVY
CHAIN
(Homo
sapiens)		4 / 6
LEU H 159
VAL H 182
LEU H 138
VAL H 184
1.39A21.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6w41 CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 6
LEU L  11
VAL L  13
LEU L  78
ARG L  18
1.43A20.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6w41 CR3022 FAB HEAVY
CHAIN
(Homo
sapiens)		4 / 6
LEU H  82
LEU H  80
ARG H  38
VAL H 109
1.80A21.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6w41 CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 6
LEU L  78
ARG L  18
VAL L  13
VAL L 104
1.70A20.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 6
LEU A  89
VAL A  68
LEU A  75
VAL A  18
1.47A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 6
LEU A 262
VAL A 261
LEU A 205
VAL A 247
1.35A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6w6y NSP3
(SARS-CoV-2)		4 / 6
VAL B  16
LEU B 153
ARG B 141
VAL B 144
1.77A18.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6w6y NSP3
(SARS-CoV-2)		4 / 6
LEU A 153
VAL A 151
LEU A 122
VAL A 147
1.15A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6w6y NSP3
(SARS-CoV-2)		5 / 10
VAL A  95
LEU A 127
TYR A 113
LEU A 109
SER A 128
1.78A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBF_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6w6y NSP3
(SARS-CoV-2)		5 / 9
VAL A  95
LEU A 127
TYR A 113
LEU A 109
SER A 128
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6w6y NSP3
(SARS-CoV-2)		5 / 10
GLY B  79
VAL B  95
LEU B  93
TYR B  68
ALA B  39
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6w6y NSP3
(SARS-CoV-2)		4 / 6
LEU A  12
VAL A  16
LEU A 153
VAL A 144
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6w6y NSP3
(SARS-CoV-2)		5 / 10
GLY B 130
LEU B 126
TYR B 113
LEU B 109
ALA B  38
1.64A
MES  B 201 ( 3.4A)
None
None
None
MES  B 201 ( 3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6w6y NSP3
(SARS-CoV-2)		4 / 6
LEU A 122
VAL A  36
LEU A 127
VAL A  95
1.74A18.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6w6y NSP3
(SARS-CoV-2)		4 / 6
LEU B 153
VAL B 151
LEU B 122
VAL B 147
1.13A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6w6y NSP3
(SARS-CoV-2)		4 / 6
LEU B  12
VAL B  16
LEU B 153
VAL B 144
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6w6y NSP3
(SARS-CoV-2)		5 / 10
GLY A  79
VAL A  95
LEU A  93
TYR A  68
ALA A  39
1.46A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6w6y NSP3
(SARS-CoV-2)		4 / 6
LEU A 122
VAL A 151
ARG A 148
VAL A 147
1.74A18.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6w6y NSP3
(SARS-CoV-2)		4 / 6
LEU A 140
ARG A 141
VAL A 144
VAL A  16
1.20A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6w75 NSP16
(SARS-CoV-2)		4 / 6
ARG C6864
VAL A7094
LEU C6892
VAL A7092
1.75A19.66
FMT  C7106 ( 2.7A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6w75 NSP16
(SARS-CoV-2)		4 / 6
VAL A7094
LEU C6892
ARG C7081
VAL C7086
1.78A19.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6w9q 3C-LIKE PROTEINASE
PEPTIDE, NSP9 FUSION
(SARS-CoV-2)		5 / 10
GLY A 100
LEU A 106
TYR A  31
LEU A   9
SER A 105
1.80A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6wcf NSP3
(SARS-CoV-2)		4 / 6
LEU A 153
VAL A 151
LEU A 122
VAL A 147
1.15A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6wcf NSP3
(SARS-CoV-2)		5 / 10
GLY A  79
VAL A  95
LEU A  93
TYR A  68
ALA A  39
1.37A
None
None
None
None
MES  A 201 ( 4.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6wcf NSP3
(SARS-CoV-2)		4 / 6
LEU A  12
VAL A  16
LEU A 153
VAL A 144
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6wcf NSP3
(SARS-CoV-2)		5 / 10
GLY A 130
LEU A 126
TYR A 113
LEU A 109
ALA A  38
1.61A
MES  A 201 (-3.2A)
None
None
None
MES  A 201 (-3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6wen NSP3
(SARS-CoV-2)		5 / 10
GLY A  79
VAL A  95
LEU A  93
TYR A  68
ALA A  39
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6wen NSP3
(SARS-CoV-2)		4 / 6
LEU A 153
VAL A 151
LEU A 122
VAL A 147
1.18A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6wen NSP3
(SARS-CoV-2)		5 / 10
VAL A  95
LEU A 127
TYR A 113
LEU A 109
SER A 128
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6wen NSP3
(SARS-CoV-2)		4 / 6
LEU A 140
ARG A 141
VAL A 144
VAL A  16
1.25A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBF_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6wey NSP3
(SARS-CoV-2)		5 / 9
VAL A 299
LEU A 331
TYR A 317
LEU A 313
SER A 332
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6wey NSP3
(SARS-CoV-2)		5 / 10
VAL A 299
LEU A 331
TYR A 317
LEU A 313
SER A 332
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6wey NSP3
(SARS-CoV-2)		4 / 6
LEU A 357
VAL A 355
LEU A 326
VAL A 351
1.17A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6wey NSP3
(SARS-CoV-2)		4 / 6
LEU A 216
VAL A 220
LEU A 357
VAL A 348
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6wey NSP3
(SARS-CoV-2)		5 / 10
GLY A 283
VAL A 299
LEU A 297
TYR A 272
ALA A 243
1.35A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 6
LEU B   3
VAL B  25
LEU B  43
VAL B  23
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		4 / 6
LEU A   3
VAL A  25
LEU A  43
VAL A  23
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 6
LEU A 262
VAL A 261
LEU A 205
VAL A 247
1.35A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 10
GLY B 130
LEU B 126
TYR B 113
LEU B 109
ALA B  38
1.59A
APR  B 201 (-3.3A)
None
None
None
APR  B 201 (-3.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
LEU A  12
VAL A  16
LEU A 153
VAL A 144
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
LEU A 153
VAL A 151
LEU A 122
VAL A 147
1.13A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 10
GLY A  79
VAL A  95
LEU A  93
TYR A  68
ALA A  39
1.41A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
LEU D 153
VAL D 151
LEU D 122
VAL D 147
1.14A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
LEU B 153
VAL B 151
LEU B 122
VAL B 147
1.14A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBF_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 9
VAL D  95
LEU D 127
TYR D 113
LEU D 109
SER D 128
1.74A
None
None
None
None
APR  D 201 (-4.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 10
GLY D 130
LEU D 126
TYR D 113
LEU D 109
ALA D  38
1.58A
APR  D 201 (-3.2A)
None
None
None
APR  D 201 (-3.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
LEU B  12
VAL B  16
LEU B 153
VAL B 144
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 10
GLY B  79
VAL B  95
LEU B  93
TYR B  68
ALA B  39
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
LEU D  12
VAL D  16
LEU D 153
VAL D 144
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 10
GLY C 130
LEU C 126
TYR C 113
LEU C 109
ALA C  38
1.60A
APR  C 201 (-3.0A)
APR  C 201 (-4.9A)
None
None
APR  C 201 (-3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 10
GLY A 130
LEU A 126
TYR A 113
LEU A 109
ALA A  38
1.61A
APR  A 201 (-3.5A)
None
None
None
APR  A 201 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 10
GLY C  79
VAL C  95
LEU C  93
TYR C  68
ALA C  39
1.41A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBF_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 9
VAL B  95
LEU B 127
TYR B 113
LEU B 109
SER B 128
1.74A
None
None
None
None
APR  B 201 (-4.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 10
VAL B  95
LEU B 127
TYR B 113
LEU B 109
SER B 128
1.78A
None
None
None
None
APR  B 201 (-4.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 10
GLY D  79
VAL D  95
LEU D  93
TYR D  68
ALA D  39
1.34A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
LEU C 153
VAL C 151
LEU C 122
VAL C 147
1.18A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 10
VAL D  95
LEU D 127
TYR D 113
LEU D 109
SER D 128
1.78A
None
None
None
None
APR  D 201 (-4.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 6
LEU A  75
ARG A  76
VAL A  91
VAL A  36
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 6
LEU A 262
VAL A 261
LEU A 205
VAL A 247
1.31A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6wrh PEPTIDASE C16
(SARS-CoV-2)		5 / 10
GLY A 160
VAL A 159
LEU A 113
TYR A 112
ALA A  86
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
ARG A  40
VAL A  42
LEU A  87
VAL A  20
1.59A18.18
DMS  A 408 (-3.3A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
LEU A  89
VAL A  68
LEU A  75
VAL A  20
1.77A18.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
LEU A  89
VAL A  68
LEU A  75
VAL A  18
1.45A18.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
LEU A 115
VAL A  13
LEU A  30
VAL A 157
1.78A18.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
LEU A 262
VAL A 261
LEU A 205
VAL A 247
1.35A18.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
LEU A  75
ARG A  76
VAL A  91
VAL A  36
1.54A18.18
None
DMS  A 401 (-3.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6yla HEAVY CHAIN
(Homo
sapiens)		4 / 6
LEU H 163
VAL H 186
LEU H 142
VAL H 188
1.44A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6yla LIGHT CHAIN
(Homo
sapiens)		4 / 6
LEU C  11
VAL C  13
LEU C  84
ARG C  18
1.33A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6yla LIGHT CHAIN
(Homo
sapiens)		4 / 6
LEU L  11
VAL L  13
LEU L  84
ARG L  18
1.04A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6yla HEAVY CHAIN
(Homo
sapiens)		4 / 6
LEU B 163
VAL B 186
LEU B 142
VAL B 188
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6ym0 HEAVY CHAIN
(Homo
sapiens)		4 / 6
LEU H 163
VAL H 186
LEU H 142
VAL H 188
1.41A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6ym0 LIGHT CHAIN
(Homo
sapiens)		4 / 6
LEU L  11
VAL L  13
LEU L  84
ARG L  18
1.06A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
LEU A  89
VAL A  68
LEU A  75
VAL A  18
1.46A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
LEU A 262
VAL A 261
LEU A 205
VAL A 247
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
LEU A  75
ARG A  76
VAL A  91
VAL A  36
1.51A
None
DMS  A 501 (-3.1A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
ARG A  40
VAL A  42
LEU A  87
VAL A  20
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6yor IGG L CHAIN
(Homo
sapiens)		4 / 6
LEU L  11
VAL L  13
LEU L  84
ARG L  18
1.02A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6yor IGG H CHAIN
(Homo
sapiens)		4 / 6
LEU H 163
VAL H 186
LEU H 142
VAL H 188
1.44A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6yor IGG L CHAIN
(Homo
sapiens)		4 / 6
LEU C  11
VAL C  13
LEU C  84
ARG C  18
1.02A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6yor IGG H CHAIN
(Homo
sapiens)		4 / 6
LEU B 163
VAL B 186
LEU B 142
VAL B 188
1.44A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
LEU A 262
VAL A 261
LEU A 205
VAL A 247
1.33A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
ARG A  40
VAL A  42
LEU A  87
VAL A  20
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
LEU A  75
ARG A  76
VAL A  91
VAL A  36
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
LEU A  27
VAL A  20
LEU A  89
VAL A  18
1.62A
PK8  A 401 ( 3.6A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 6
LEU A  89
VAL A  68
LEU A  75
VAL A  18
1.41A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
LEU E 153
VAL E 151
LEU E 122
VAL E 147
1.17A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
LEU B 153
VAL B 151
LEU B 122
VAL B 147
1.23A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBF_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 9
VAL B  95
LEU B 127
TYR B 113
LEU B 109
SER B 128
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
LEU C  12
VAL C  16
LEU C 153
VAL C 144
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
LEU E 140
ARG E 141
VAL E 144
VAL E  16
1.31A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
LEU C 153
VAL C 151
LEU C 122
VAL C 147
1.18A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
GLY E  79
VAL E  95
LEU E  93
TYR E  68
ALA E  39
1.42A
EPE  E 203 (-3.3A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
VAL B  95
LEU B 127
TYR B 113
LEU B 109
SER B 128
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
LEU D  12
VAL D  16
LEU D 153
VAL D 144
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
GLY E 130
LEU E 126
TYR E 113
LEU E 109
ALA E  38
1.74A
EPE  E 202 ( 4.5A)
None
None
None
EPE  E 202 (-3.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
GLY C  79
VAL C  95
LEU C  93
TYR C  68
ALA C  39
1.40A
EPE  C 202 (-3.4A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
GLY A 130
LEU A 126
TYR A 113
LEU A 109
ALA A  38
1.74A
EDO  A 202 ( 4.4A)
None
None
None
EDO  A 202 (-3.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
GLY A  79
VAL A  95
LEU A  93
TYR A  68
ALA A  39
1.42A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
GLY C 130
LEU C 126
TYR C 113
LEU C 109
ALA C  38
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
LEU B  12
VAL B  16
LEU B 153
VAL B 144
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
GLY B  79
VAL B  95
LEU B  93
TYR B  68
ALA B  39
1.41A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
GLY D  79
VAL D  95
LEU D  93
TYR D  68
ALA D  39
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
LEU A  12
VAL A  16
LEU A 153
VAL A 144
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
LEU D 153
VAL D 151
LEU D 122
VAL D 147
1.18A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
LEU A 153
VAL A 151
LEU A 122
VAL A 147
1.18A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
LEU B 153
VAL B 151
LEU B 122
VAL B 147
1.23A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
LEU D 153
VAL D 151
LEU D 122
VAL D 147
1.20A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
GLY E  79
VAL E  95
LEU E  93
TYR E  68
ALA E  39
1.44A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
VAL A  95
LEU A 127
TYR A 113
LEU A 109
SER A 128
1.79A
None
None
None
None
APR  A 201 (-4.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
GLY D 130
LEU D 126
TYR D 113
LEU D 109
ALA D  38
1.66A
APR  D 201 (-3.2A)
APR  D 201 (-4.5A)
None
None
APR  D 201 (-3.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
GLY A 130
LEU A 126
TYR A 113
LEU A 109
ALA A  38
1.63A
APR  A 201 ( 3.2A)
APR  A 201 (-4.8A)
None
None
APR  A 201 (-3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
LEU E 140
ARG E 141
VAL E 144
VAL E  16
1.24A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
LEU D  12
VAL D  16
LEU D 153
VAL D 144
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
GLY E 130
LEU E 126
TYR E 113
LEU E 109
ALA E  38
1.64A
APR  E 201 (-3.2A)
APR  E 201 (-4.7A)
None
None
APR  E 201 (-3.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
LEU E  12
VAL E  16
LEU E 153
VAL E 144
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
LEU A 153
VAL A 151
LEU A 122
VAL A 147
1.20A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
GLY B 130
LEU B 126
TYR B 113
LEU B 109
ALA B  38
1.65A
APR  B 201 (-3.2A)
APR  B 201 (-4.7A)
None
None
APR  B 201 (-3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
LEU C  12
VAL C  16
LEU C 153
VAL C 144
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
LEU A  12
VAL A  16
LEU A 153
VAL A 144
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
GLY C 130
LEU C 126
TYR C 113
LEU C 109
ALA C  38
1.66A
APR  C 201 (-3.2A)
APR  C 201 (-4.8A)
None
None
APR  C 201 (-3.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
GLY A  79
VAL A  95
LEU A  93
TYR A  68
ALA A  39
1.44A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
VAL C  95
LEU C 127
TYR C 113
LEU C 109
SER C 128
1.80A
None
None
None
None
APR  C 201 (-4.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
LEU B  12
VAL B  16
LEU B 153
VAL B 144
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
GLY D  79
VAL D  95
LEU D  93
TYR D  68
ALA D  39
1.50A
EDO  D 203 (-3.1A)
None
None
EDO  D 202 (-4.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
GLY C  79
VAL C  95
LEU C  93
TYR C  68
ALA C  39
1.42A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
VAL B  95
LEU B 127
TYR B 113
LEU B 109
SER B 128
1.79A
None
None
None
None
APR  B 201 (-4.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
GLY B  79
VAL B  95
LEU B  93
TYR B  68
ALA B  39
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
VAL D  95
LEU D 127
TYR D 113
LEU D 109
SER D 128
1.80A
None
None
None
None
APR  D 201 (-4.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
LEU E 153
VAL E 151
LEU E 122
VAL E 147
1.15A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
LEU C 153
VAL C 151
LEU C 122
VAL C 147
1.17A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
LEU B 153
VAL B 151
LEU B 122
VAL B 147
1.19A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
GLY B  79
VAL B  95
LEU B  93
TYR B  68
ALA B  39
1.43A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
GLY A  79
VAL A  95
LEU A  93
TYR A  68
ALA A  39
1.40A
EDO  A 204 (-3.6A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
GLY B 130
LEU B 126
TYR B 113
LEU B 109
ALA B  38
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
GLY A 130
LEU A 126
TYR A 113
LEU A 109
ALA A  38
1.62A
MES  A 201 (-3.1A)
None
None
None
MES  A 201 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
LEU C 153
VAL C 151
LEU C 122
VAL C 147
1.17A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
LEU B  12
VAL B  16
LEU B 153
VAL B 144
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 10
GLY C  79
VAL C  95
LEU C  93
TYR C  68
ALA C  39
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
LEU A 153
VAL A 151
LEU A 122
VAL A 147
1.19A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		4 / 6
LEU C  12
VAL C  16
LEU C 153
VAL C 144
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		7bqy MAIN PROTEASE
(SARS-CoV-2)		4 / 6
ARG A  40
VAL A  42
LEU A  87
VAL A  20
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		7bqy MAIN PROTEASE
(SARS-CoV-2)		4 / 6
LEU A 262
VAL A 261
LEU A 205
VAL A 247
1.32A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		7bqy MAIN PROTEASE
(SARS-CoV-2)		4 / 6
LEU A  89
VAL A  68
LEU A  75
VAL A  18
1.47A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBF_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		7btf NSP12
NSP8
(SARS-CoV-2)		5 / 9
LEU A 514
TYR A 515
SER A 518
ARG B  80
ALA B  86
1.40A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		7btf NSP8
(SARS-CoV-2)		4 / 6
LEU D 184
VAL D 159
LEU D 169
VAL D 167
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		7btf NSP12
(SARS-CoV-2)		5 / 10
GLY A 179
VAL A 182
LEU A 245
TYR A 286
ALA A 185
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		7btf NSP12
(SARS-CoV-2)		5 / 10
VAL A 182
LEU A 241
TYR A 237
TYR A 286
ALA A 185
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		4 / 6
LEU A 262
VAL A 261
LEU A 205
VAL A 247
1.30A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		7bv1 NSP12
(SARS-CoV-2)		5 / 10
GLY A 179
VAL A 182
LEU A 245
TYR A 286
ALA A 185
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		7bv1 NSP12
(SARS-CoV-2)		4 / 6
LEU A 241
ARG A 132
LEU A 131
VAL A 182
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		7bv1 NSP12
(SARS-CoV-2)		5 / 10
GLY A 179
VAL A 182
LEU A 241
TYR A 286
ALA A 185
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		7bv1 NSP12
(SARS-CoV-2)		5 / 10
VAL A 182
LEU A 241
TYR A 237
TYR A 286
ALA A 185
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		7bv1 NSP12
(SARS-CoV-2)		4 / 6
ARG A 750
VAL A 475
LEU A 749
VAL A 472
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBF_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		7bv1 NSP12
NSP8
(SARS-CoV-2)		5 / 9
LEU A 514
TYR A 515
SER A 518
ARG B  80
ALA B  86
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		7bv1 NSP12
(SARS-CoV-2)		4 / 6
LEU A 638
ARG A 631
VAL A 693
VAL A 476
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBF_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		7bv2 NSP12
NSP8
(SARS-CoV-2)		5 / 9
LEU A 514
TYR A 515
SER A 518
ARG B  80
ALA B  86
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		7bv2 NSP12
(SARS-CoV-2)		4 / 6
ARG A 750
VAL A 475
LEU A 749
VAL A 472
1.52A
None