Ligand ID: AMH


Drugbank ID:
DB00302
(Tranexamic Acid)


Indication:
For use in patients with hemophilia for short term use (two to eight days) to reduce or prevent hemorrhage and reduce the need for replacement therapy during and following tooth extraction. It can also be used for excessive bleeding in menstruation, surgery, or trauma cases.

Get human targets for AMH in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND 'AMH'

Click here for results that match SARS-Cov-2 / COVID-19 structures only
Click here for results that match SARS-related structures only


1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1B2I_A_AMHA84_1
(PROTEIN
(PLASMINOGEN))		2ajf ACE2
(Homo
sapiens)		4 / 7
TYR B 199
PHE B 464
ARG B 460
TRP B 461
1.46A8.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V3C_A_AMHA402_1
(QUEUINE
TRNA-RIBOSYLTRANSFER
ASE)		2fav REPLICASE
POLYPROTEIN 1AB
(PP1AB) (ORF1AB)
(SARSr-CoV)		5 / 9
ASP B  15
GLN B 151
GLY A  48
GLY A  49
ALA A  39
1.71A16.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V3C_A_AMHA402_1
(QUEUINE
TRNA-RIBOSYLTRANSFER
ASE)		2jw8 NUCLEOCAPSID PROTEIN
(SARSr-CoV)		5 / 9
GLN B 284
GLY B 285
GLY B 276
ALA B 274
MET A 318
1.75A13.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEB_A_AMHA90_1
(PLASMINOGEN)		2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		4 / 7
ARG B 198
ASP B 301
ASP B 300
ARG B 206
1.67A13.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V3C_A_AMHA402_1
(QUEUINE
TRNA-RIBOSYLTRANSFER
ASE)		2qcy 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 9
ASP A 295
CYH A 128
GLY A 138
ALA A 116
VAL A 114
1.66A22.73
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V3C_A_AMHA402_1
(QUEUINE
TRNA-RIBOSYLTRANSFER
ASE)		2w2g NSP3
(SARSr-CoV)		5 / 9
TYR A 422
ASP A 424
GLN A 490
GLY A 491
ALA A 590
1.77A22.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1B2I_A_AMHA84_1
(PROTEIN
(PLASMINOGEN))		3d0h ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 7
TYR A 199
PHE A 464
ARG A 460
TRP A 461
1.37A8.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1B2I_A_AMHA84_1
(PROTEIN
(PLASMINOGEN))		3scl ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 7
TYR A 183
ASP A 509
PHE A 464
ARG A 460
1.67A8.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V3C_A_AMHA402_1
(QUEUINE
TRNA-RIBOSYLTRANSFER
ASE)		5c8s GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		5 / 9
ASP D 415
CYH D 414
GLY D 417
GLY D 413
VAL D 282
1.65A23.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V3C_A_AMHA402_1
(QUEUINE
TRNA-RIBOSYLTRANSFER
ASE)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		5 / 9
ASP A 415
CYH A 414
GLY A 417
GLY A 413
VAL A 282
1.58A22.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEB_A_AMHA90_1
(PLASMINOGEN)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		4 / 7
ARG B 553
ASP C  57
TYR C  53
ARG C  48
1.75A5.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1B2I_A_AMHA84_1
(PROTEIN
(PLASMINOGEN))		5x5c S PROTEIN
(MERS-CoV)		4 / 7
TYR C 541
ASP C 539
GLU C 536
TRP C 535
1.66A4.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1B2I_A_AMHA84_1
(PROTEIN
(PLASMINOGEN))		6acj ACE2
(Homo
sapiens)		4 / 7
TYR D 183
ASP D 509
PHE D 464
ARG D 460
1.30A9.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V3C_A_AMHA402_1
(QUEUINE
TRNA-RIBOSYLTRANSFER
ASE)		6ack SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 9
TYR A 438
ASP A 480
GLY A 482
GLY A 434
ALA A 430
1.59A15.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEB_A_AMHA90_1
(PLASMINOGEN)		6cs1 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 7
ASP C 480
TYR C 338
ARG C 441
TYR C 440
1.64A5.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1B2I_A_AMHA84_1
(PROTEIN
(PLASMINOGEN))		6cs2 ACE2
(Homo
sapiens)		4 / 7
TYR D 183
ASP D 509
PHE D 464
ARG D 460
1.58A9.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEB_A_AMHA90_1
(PLASMINOGEN)		6jyt HELICASE
(SARSr-CoV)		4 / 7
ASP B 119
ASP B 113
TRP B 114
ARG B 409
1.44A9.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1B2I_A_AMHA84_1
(PROTEIN
(PLASMINOGEN))		6m17 ACE2
(Homo
sapiens)		4 / 7
TYR B 183
ASP B 509
PHE B 464
ARG B 460
1.65A7.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V3C_A_AMHA402_1
(QUEUINE
TRNA-RIBOSYLTRANSFER
ASE)		6m1d ACE2
(Homo
sapiens)		5 / 9
TYR B 381
ASP B 382
GLY B 561
GLY B 395
ALA B 569
1.66A18.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V3C_A_AMHA402_1
(QUEUINE
TRNA-RIBOSYLTRANSFER
ASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 9
GLN D 118
GLY A  78
GLY A  79
ALA A  39
VAL A  95
1.80A17.32
EDO  D 201 ( 4.4A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V3C_A_AMHA402_1
(QUEUINE
TRNA-RIBOSYLTRANSFER
ASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 9
GLN A 118
GLY D  78
GLY D  79
ALA D  39
VAL D  95
1.78A17.32
EDO  D 201 ( 4.5A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V3C_A_AMHA402_1
(QUEUINE
TRNA-RIBOSYLTRANSFER
ASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 9
GLN A 118
GLY D  78
GLY D  79
ALA D  39
VAL D  95
1.76A17.32
EDO  D 203 (-3.7A)
None
EDO  D 203 (-3.1A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V3C_A_AMHA402_1
(QUEUINE
TRNA-RIBOSYLTRANSFER
ASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 9
GLN D 118
GLY A  78
GLY A  79
ALA A  39
VAL A  95
1.79A17.32
EDO  A 207 ( 4.7A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V3C_A_AMHA402_1
(QUEUINE
TRNA-RIBOSYLTRANSFER
ASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 9
GLN C 118
GLY A  78
GLY A  79
ALA A  39
VAL A  95
1.79A17.32
EDO  A 204 (-4.1A)
None
EDO  A 204 (-3.6A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V3C_A_AMHA402_1
(QUEUINE
TRNA-RIBOSYLTRANSFER
ASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 9
GLN A 118
GLY C  78
GLY C  79
ALA C  39
VAL C  95
1.77A17.32
EDO  A 202 (-4.6A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEB_A_AMHA90_1
(PLASMINOGEN)		7btf NSP12
(SARS-CoV-2)		4 / 7
ARG A  55
ASP A  67
TYR A 122
ARG A  33
1.68A6.71
None