Ligand ID: 84G


Drugbank ID:
DB06696
(Arbekacin)


Indication:
Arbekacin is used for the short term treatment of multi-resistant bacterial infections, such as methicillin-resistant Staphylococcus aureus (MRSA).

Get human targets for 84G in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND '84G'

Click here for results that match SARS-Cov-2 / COVID-19 structures only
Click here for results that match SARS-related structures only


1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CGG_D_84GD600_0
(BIFUNCTIONAL AAC/APH)		1uk3 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
ASP A 295
ASN A 203
GLU A 290
GLU A 288
TYR A 126
1.46A18.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CGG_D_84GD600_0
(BIFUNCTIONAL AAC/APH)		2cme HYPOTHETICAL PROTEIN
5
(SARSr-CoV)		5 / 11
ASP E  63
SER E  64
ASN E  61
GLU B  87
GLU E  66
1.75A12.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CGG_B_84GB600_0
(BIFUNCTIONAL AAC/APH)		2cme HYPOTHETICAL PROTEIN
5
(SARSr-CoV)		5 / 10
ASP E  63
SER E  64
ASN E  61
GLU B  87
GLU E  66
1.74A12.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CGG_D_84GD600_0
(BIFUNCTIONAL AAC/APH)		5x5f S PROTEIN
(MERS-CoV)		5 / 11
SER B 583
ASN B 406
TYR B 609
GLU B 376
TYR B 642
1.78A12.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CGG_D_84GD600_0
(BIFUNCTIONAL AAC/APH)		6m1d ACE2
(Homo
sapiens)		5 / 11
ASP B 206
TYR B 207
GLU B 457
TYR B 515
GLU B 402
1.43A16.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CGG_D_84GD600_0
(BIFUNCTIONAL AAC/APH)		6m71 NSP12
(SARS-CoV-2)		5 / 11
ASP A 833
SER A 835
HIS A 439
GLU A 436
GLU A 876
1.51A14.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CGG_B_84GB600_0
(BIFUNCTIONAL AAC/APH)		6m71 NSP12
(SARS-CoV-2)		5 / 10
ASP A 833
SER A 835
HIS A 439
GLU A 436
GLU A 876
1.49A14.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CGG_B_84GB600_0
(BIFUNCTIONAL AAC/APH)		6nur NSP12
(SARSr-CoV)		5 / 10
ASP A 833
SER A 835
HIS A 439
GLU A 436
GLU A 876
1.67A13.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CGG_D_84GD600_0
(BIFUNCTIONAL AAC/APH)		6nur NSP12
(SARSr-CoV)		5 / 11
ASP A 833
SER A 835
HIS A 439
GLU A 436
GLU A 876
1.35A13.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CGG_D_84GD600_0
(BIFUNCTIONAL AAC/APH)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		5 / 11
SER C 180
ASN C 144
HIS B 168
GLU C 149
GLU C 111
1.24A22.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CGG_B_84GB600_0
(BIFUNCTIONAL AAC/APH)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		5 / 10
SER L 180
ASN L 144
HIS H 168
GLU L 149
GLU L 111
1.46A22.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CGG_D_84GD600_0
(BIFUNCTIONAL AAC/APH)		6yla HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		5 / 11
SER L 180
ASN L 144
HIS H 168
GLU L 149
GLU L 111
1.38A22.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CGG_B_84GB600_0
(BIFUNCTIONAL AAC/APH)		6ym0 HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		5 / 10
SER L 180
ASN L 144
HIS H 168
GLU L 149
GLU L 111
1.32A22.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CGG_D_84GD600_0
(BIFUNCTIONAL AAC/APH)		6ym0 HEAVY CHAIN
LIGHT CHAIN
(Homo
sapiens)		5 / 11
SER L 180
ASN L 144
HIS H 168
GLU L 149
GLU L 111
1.25A22.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CGG_D_84GD600_0
(BIFUNCTIONAL AAC/APH)		7btf NSP12
(SARS-CoV-2)		5 / 11
ASP A 833
SER A 835
HIS A 439
GLU A 436
GLU A 876
1.53A14.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CGG_D_84GD600_0
(BIFUNCTIONAL AAC/APH)		7bv1 NSP12
(SARS-CoV-2)		5 / 11
ASP A 833
SER A 835
HIS A 439
GLU A 436
GLU A 876
1.54A14.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CGG_B_84GB600_0
(BIFUNCTIONAL AAC/APH)		7bv2 NSP12
(SARS-CoV-2)		5 / 10
ASP A 833
SER A 835
HIS A 439
GLU A 436
GLU A 876
1.30A14.09
None