Ligand ID: 6ZZ


Drugbank ID:
DB11730
(Ribociclib)


Indication:
Kisqali (ribociclib) is a selective cyclin-dependent kinase inhibitor, a class of drugs that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and 6 (CDK4/6). These proteins, when over-activated, can enable cancer cells to grow and divide too quickly. Targeting CDK4/6 with enhanced precision may play a role in ensuring that cancer cells do not continue to replicate uncontrollably.

Get human targets for 6ZZ in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND '6ZZ'

Click here for results that match SARS-Cov-2 / COVID-19 structures only
Click here for results that match SARS-related structures only


1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_2
(CYCLIN-DEPENDENT
KINASE 6)		1z1i 3C-LIKE PROTEINASE
(SARSr-CoV)		3 / 3
LYS A  97
GLN A  69
ASN A  72
1.44A21.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_2
(CYCLIN-DEPENDENT
KINASE 6)		1zv8 E2 GLYCOPROTEIN
(SARSr-CoV)		3 / 3
LYS J  14
GLN I  15
ASN J  25
1.55A9.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		2acf REPLICASE
POLYPROTEIN 1AB
(SARS-COV
Tor2)		5 / 12
ILE D 335
VAL D 333
ALA D 306
VAL D 277
LEU D 309
1.14A18.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		2fav REPLICASE
POLYPROTEIN 1AB
(PP1AB) (ORF1AB)
(SARSr-CoV)		5 / 12
ILE C 154
VAL C 152
ALA C 125
VAL C  96
LEU C 128
1.14A22.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_2
(CYCLIN-DEPENDENT
KINASE 6)		2k87 NSP3 OF REPLICASE
POLYPROTEIN 1A
(SARSr)		3 / 3
LYS A  24
GLN A  91
ASN A  29
1.42A15.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		6 / 12
ILE B 314
VAL D  77
ALA D  80
VAL D  66
HIS D  95
ASP D  87
1.69A23.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 12
ILE B  42
VAL B  10
ALA B   6
ASP B  39
THR A  48
1.33A23.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_2
(CYCLIN-DEPENDENT
KINASE 6)		2vj1 MAIN PROTEINASE
(SARSr-CoV)		3 / 3
LYS A   5
GLN A 110
ASN A 203
1.74A22.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		3e9s NSP3
(SARSr-CoV)		6 / 12
GLY A  29
HIS A  51
THR A  10
LEU A  37
ALA A  40
ASP A  41
1.64A22.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		3i6g HLA, A-2
MEMBRANE PROTEIN
(Homo
sapiens)		5 / 12
GLY A  62
ALA A  69
HIS A  70
THR A 163
LEU C   4
1.33A20.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		3iwm 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
VAL D 157
VAL D 148
PHE D 150
THR D  35
LEU D  30
1.39A21.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_2
(CYCLIN-DEPENDENT
KINASE 6)		3m3s 3C-LIKE PROTEINASE
(SARSr-CoV)		3 / 3
LYS A   5
GLN A 110
ASN A 203
1.75A21.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_2
(CYCLIN-DEPENDENT
KINASE 6)		3r24 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		3 / 3
LYS A 170
GLN A  28
ASN A  29
1.17A21.33
SAM  A 302 (-3.1A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		4ovz PAPAIN-LIKE
PROTEINASE
(SARS-COV
Urbani)		5 / 12
GLY A  29
THR A  10
LEU A  37
ALA A  40
ASP A  41
1.32A22.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		5c8t GUANINE-N7
METHYLTRANSFERASE
NSP10
(SARSr-CoV)		5 / 12
GLY C  -1
VAL D 101
ALA D 100
THR D 193
LEU D 105
1.38A17.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_2
(CYCLIN-DEPENDENT
KINASE 6)		5c8u GUANINE-N7
METHYLTRANSFERASE
NSP10
(SARSr-CoV)		3 / 3
LYS A  25
GLN B  65
ASN B  67
1.74A17.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		5e6j REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
GLY A  29
THR A  10
LEU A  37
ALA A  40
ASP A  41
1.26A22.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		5 / 12
ALA M   1
HIS M   0
THR A 193
ALA M   4
ASP A  10
1.32A15.96
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
ILE A 200
VAL A 204
PHE A 230
HIS A 246
ALA A 234
1.74A18.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
ILE A 136
ALA A 173
HIS A 172
ASP A 197
ALA A 194
1.80A18.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
ILE A 136
ALA A 173
PHE A 185
HIS A 172
ALA A 194
1.53A18.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		5x4s SPIKE GLYCOPROTEIN
(SARSr-CoV)		6 / 12
ILE A 228
GLY A 104
VAL A 196
PHE A 187
THR A 160
LEU A 222
1.67A20.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 12
GLY C  68
PHE C 231
ASP C  77
THR C  75
ALA C 233
1.37A12.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		6 / 12
VAL A 842
ALA A 714
HIS A1040
ASP A 812
THR A 809
ALA A 938
1.32A12.59
VAL  A 842 ( 0.6A)
ALA  A 714 ( 0.0A)
HIS  A1040 ( 1.0A)
ASP  A 812 ( 0.5A)
THR  A 809 ( 0.8A)
ALA  A 938 ( 0.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_2
(CYCLIN-DEPENDENT
KINASE 6)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		3 / 3
LYS A 190
GLN B 549
ASN B 505
1.57A12.59
LYS  A 190 ( 0.0A)
GLN  B 549 ( 0.6A)
ASN  B 505 ( 0.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_2
(CYCLIN-DEPENDENT
KINASE 6)		6acg SPIKE GLYCOPROTEIN
(SARSr-CoV)		3 / 3
LYS B 333
GLN A 112
ASN A 158
1.69A12.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6acj SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
ILE B 228
GLY B 104
VAL B 196
PHE B 187
LEU B 194
1.16A12.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		6 / 12
ILE B 228
GLY B 104
VAL B 196
PHE B 187
THR B 160
LEU B 222
1.53A13.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6crw SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
VAL B 842
ALA B 714
HIS B1040
THR B 809
ALA B 938
1.19A12.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_2
(CYCLIN-DEPENDENT
KINASE 6)		6crx SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		3 / 3
LYS B1020
GLN B1088
ASN B1090
1.78A12.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
ALA A  49
VAL A  28
PHE A  33
ASP A 177
LEU A 179
1.24A21.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6jyt HELICASE
(SARSr-CoV)		5 / 12
GLY A 196
VAL A 157
THR A 199
LEU A 163
ASP A 223
1.31A22.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_2
(CYCLIN-DEPENDENT
KINASE 6)		6lxt SPIKE PROTEIN S2
(SARS-CoV-2)		3 / 3
LYS B 914
GLN B1201
ASN C 919
1.57A17.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6lze VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
ILE A 136
ALA A 173
PHE A 185
HIS A 163
ALA A 194
1.67A22.09
None
None
None
ELL  D   3 (-3.9A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6lze VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
ILE A 136
ALA A 173
PHE A 185
HIS A 172
ALA A 194
1.51A22.09
None
None
None
ELL  D   3 (-4.6A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6lzg SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL B 524
ALA B 363
THR B 430
LEU B 513
ALA B 397
1.28A24.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
ILE A 136
ALA A 173
PHE A 185
HIS A 172
ALA A 194
1.51A21.70
None
None
None
ELL  D   3 (-4.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ILE D 136
ALA D 173
PHE D 185
HIS D 172
ALA D 194
1.52A22.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ILE C 136
ALA C 173
PHE C 185
HIS C 172
ALA C 194
1.53A22.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ILE A 200
VAL A 296
PHE A 291
THR A 243
ALA A 206
1.43A22.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6m71 NSP12
NSP8
(SARS-CoV-2)		5 / 12
ILE B 107
VAL B 115
ASP B  99
LEU B  98
ALA A 383
1.60A21.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6m71 NSP12
(SARS-CoV-2)		5 / 12
ALA A 878
PHE A 881
HIS A 872
ASP A 833
ALA A 866
1.65A16.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ILE A 664
GLY A 311
ALA A 672
THR A 604
ALA A 609
1.34A13.46
None
None
None
NAG  A1301 (-3.9A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6vxs NSP3
(SARS-CoV-2)		5 / 12
VAL A  95
ALA A  39
VAL A  49
HIS A  45
LEU A  53
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6vxs NSP3
(SARS-CoV-2)		5 / 12
VAL B  95
ALA B  39
VAL B  49
HIS B  45
LEU B  53
1.41A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
ILE C 664
GLY C 311
ALA C 672
THR C 604
ALA C 609
1.38A13.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		6 / 12
ILE B 203
VAL B 227
VAL B 130
PHE B 168
THR B 240
LEU B 117
1.69A13.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6w02 NSP3
(SARS-CoV-2)		5 / 12
VAL B 151
ALA B 124
VAL B  95
LEU B 127
ALA B 112
1.36A21.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		5 / 12
GLY H 162
VAL H 182
ALA H 137
PHE L 118
THR L 172
1.72A18.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		5 / 12
VAL C 524
ALA C 363
THR C 430
LEU C 513
ALA C 397
1.42A21.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
GLY A6871
ASP A6895
THR A6908
LEU A6883
ASP A6928
1.76A19.61
SAM  A7104 (-4.4A)
None
None
None
SAM  A7104 (-3.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
GLY A6946
PHE A6868
ASP A6931
THR A6934
ASP A6912
1.70A19.61
EDO  A7102 (-3.2A)
None
EDO  A7102 (-4.6A)
KCX  A6935 ( 3.6A)
SAM  A7104 (-3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6w61 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
GLY B4322
ALA A6877
PHE A6901
LEU A6893
ALA A6905
1.74A17.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6w61 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
GLY A6869
VAL B4295
ASP A6895
THR A6908
ALA A6881
1.71A19.61
SAM  A7104 (-3.6A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6w6y NSP3
(SARS-CoV-2)		5 / 12
VAL B  95
ALA B  39
VAL B  49
HIS B  45
LEU B  53
1.35A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6w6y NSP3
(SARS-CoV-2)		5 / 12
GLY B  97
VAL B  95
VAL B 151
LEU B 153
ALA B 124
1.73A21.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6w6y NSP3
(SARS-CoV-2)		5 / 12
GLY A  97
VAL A  95
VAL A 151
LEU A 153
ALA A 124
1.75A21.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6w6y NSP3
(SARS-CoV-2)		5 / 12
VAL A  95
ALA A  39
VAL A  49
HIS A  45
LEU A  53
1.36A
None
None
AMP  A 201 ( 3.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6w6y NSP3
(SARS-CoV-2)		5 / 12
VAL B 100
THR B 146
LEU B 109
ALA B 134
ASP B 135
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6w75 NSP10
(SARS-CoV-2)		5 / 12
VAL D4274
PHE D4272
HIS B4333
ASP B4335
ALA B4276
1.68A17.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 12
GLY A6869
VAL B4295
ASP A6895
THR A6908
ALA A6881
1.73A19.61
SAM  A7102 ( 3.8A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6w75 NSP16
(SARS-CoV-2)		5 / 12
GLY A6871
ASP A6895
THR A6908
LEU A6883
ASP A6928
1.77A19.61
SAM  A7102 ( 4.2A)
None
None
None
SAM  A7102 ( 3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 12
GLY B4323
ALA A6877
PHE A6901
THR B4311
ALA A6905
1.74A17.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6w75 NSP16
(SARS-CoV-2)		5 / 12
GLY C6871
ASP C6895
THR C6908
LEU C6883
ASP C6928
1.77A19.61
SAM  C7105 ( 4.2A)
None
None
None
SAM  C7105 ( 3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 12
GLY B4322
ALA A6877
PHE A6901
LEU A6893
ALA A6905
1.75A17.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 12
GLY B4323
ALA A6877
PHE A6901
LEU A6893
ALA A6905
1.73A17.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 12
GLY D4322
ALA C6877
PHE C6901
LEU C6893
ALA C6905
1.75A17.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6w75 NSP10
NSP16
(SARS-CoV-2)		5 / 12
GLY C6869
VAL D4295
ASP C6895
THR C6908
ALA C6881
1.72A19.61
SAM  C7105 ( 3.8A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6w75 NSP10
(SARS-CoV-2)		6 / 12
ILE D4334
VAL D4274
ALA D4276
ASP B4335
ALA B4273
ASP B4275
1.77A17.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6w75 NSP16
(SARS-CoV-2)		5 / 12
GLY A6946
PHE A6868
ASP A6931
THR A6934
ASP A6912
1.62A19.61
FMT  A7108 ( 4.8A)
None
None
FMT  A7103 ( 4.4A)
SAM  A7102 ( 3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
GLY A  28
HIS A  50
THR A   9
ALA A  39
ASP A  40
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
GLY A  28
THR A   9
LEU A  36
ALA A  39
ASP A  40
1.27A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
VAL C  41
PHE C  55
HIS C  47
ALA C  39
ASP C  37
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
VAL A  57
PHE A  31
HIS A  17
ASP A  62
LEU A  64
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
GLY A  32
THR A  10
LEU A  36
ALA A  39
ASP A  40
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
GLY C  32
THR C   9
LEU C  36
ALA C  39
ASP C  40
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
GLY C  32
THR C  10
LEU C  36
ALA C  39
ASP C  40
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
GLY C  28
HIS C  50
THR C   9
ALA C  39
ASP C  40
1.50A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
GLY B  28
THR B   9
LEU B  36
ALA B  39
ASP B  40
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
GLY B  28
HIS B  50
THR B   9
ALA B  39
ASP B  40
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
GLY A  32
THR A   9
LEU A  36
ALA A  39
ASP A  40
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
GLY C  28
THR C   9
LEU C  36
ALA C  39
ASP C  40
1.25A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6wcf NSP3
(SARS-CoV-2)		5 / 12
VAL A 100
THR A 146
LEU A 109
ALA A 134
ASP A 135
1.41A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6wcf NSP3
(SARS-CoV-2)		5 / 12
VAL A  95
ALA A  39
VAL A  49
HIS A  45
LEU A  53
1.33A
None
MES  A 201 ( 4.7A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6wen NSP3
(SARS-CoV-2)		5 / 12
VAL A 100
THR A 146
LEU A 109
ALA A 134
ASP A 135
1.41A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6wen NSP3
(SARS-CoV-2)		5 / 12
VAL A  95
ALA A  39
VAL A  49
HIS A  45
LEU A  53
1.39A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6wen NSP3
(SARS-CoV-2)		5 / 12
VAL A 151
ALA A 124
VAL A  95
LEU A 127
ALA A 112
1.44A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6wey NSP3
(SARS-CoV-2)		5 / 12
VAL A 299
ALA A 243
VAL A 253
HIS A 249
LEU A 257
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
GLY C6946
PHE C6868
ASP C6931
THR C6934
ASP C6912
1.63A
None
None
None
FMT  C7104 (-4.2A)
SAH  C7102 (-3.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
GLY C7054
VAL C7086
THR C6889
LEU C6892
ASP C6923
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
GLY A6946
PHE A6868
ASP A6931
THR A6934
ASP A6912
1.65A
None
None
None
FMT  A7103 (-4.6A)
SAH  A7102 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
GLY C7054
VAL C7057
VAL C7086
LEU C6892
ASP C6923
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6wjt NSP10
(SARS-CoV-2)		5 / 12
VAL D4274
ALA D4276
ASP B4335
ALA B4273
ASP B4275
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6wjt NSP10
(SARS-CoV-2)		5 / 12
ILE D4334
VAL D4274
ALA D4276
ASP B4335
ALA B4273
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6wkq NSP10
(SARS-CoV-2)		6 / 12
ILE D4334
VAL D4274
ALA D4276
ASP B4335
ALA B4273
ASP B4275
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6wkq NSP16
(SARS-CoV-2)		5 / 12
GLY C7054
VAL C7086
THR C6889
LEU C6892
ASP C6923
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6wkq NSP16
(SARS-CoV-2)		5 / 12
GLY A6946
PHE A6868
ASP A6931
THR A6934
ASP A6912
1.67A
None
None
None
FMT  A7105 ( 4.6A)
SFG  A7103 ( 3.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6wkq NSP16
(SARS-CoV-2)		5 / 12
GLY C7054
VAL C7057
VAL C7086
LEU C6892
ASP C6923
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
GLY B 157
VAL B  78
PHE B 123
THR B 322
LEU B  76
1.58A
None
None
None
EDO  B 406 (-3.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
VAL B 102
VAL B   6
PHE B  16
THR B  48
ALA B  60
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
GLY A 130
ALA A 138
VAL A 122
ASP A 125
ALA A  82
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
ILE A  86
VAL A  67
VAL A 142
THR A  99
ASP A 125
1.42A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
GLY A 130
ALA A 138
VAL A 122
THR A 145
ALA A  82
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
GLY A 157
VAL A  78
PHE A 123
THR A 322
LEU A  76
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
ILE B  86
VAL B  67
VAL B 142
THR B  99
ASP B 125
1.42A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
VAL A 102
VAL A   6
PHE A  16
THR A  48
ALA A  60
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6wlc URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARS-CoV-2)		5 / 12
GLY B 130
ALA B 138
VAL B 122
ASP B 125
ALA B  82
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL D 100
THR D 146
LEU D 109
ALA D 134
ASP D 135
1.41A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL D 151
ALA D 124
VAL D  95
LEU D 127
ALA D 112
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL B  95
ALA B  39
VAL B  49
HIS B  45
LEU B  53
1.37A
None
None
APR  B 201 (-3.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL C  95
ALA C  39
VAL C  49
HIS C  45
LEU C  53
1.37A
None
None
APR  C 201 (-3.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL D  95
ALA D  39
VAL D  49
HIS D  45
LEU D  53
1.37A
None
None
APR  D 201 (-3.6A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL C 100
THR C 146
LEU C 109
ALA C 134
ASP C 135
1.42A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6woj REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
VAL A  95
ALA A  39
VAL A  49
HIS A  45
LEU A  53
1.36A
None
None
APR  A 201 (-3.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6wrh PEPTIDASE C16
(SARS-CoV-2)		5 / 12
GLY A  32
THR A  10
LEU A  36
ALA A  39
ASP A  40
1.62A
None
CL  A 506 (-4.0A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6wrh PEPTIDASE C16
(SARS-CoV-2)		5 / 12
GLY A  32
THR A   9
LEU A  36
ALA A  39
ASP A  40
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6wrh PEPTIDASE C16
(SARS-CoV-2)		6 / 12
GLY A  28
HIS A  50
THR A   9
LEU A  36
ALA A  39
ASP A  40
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
ILE A 200
VAL A 204
PHE A 230
HIS A 246
ALA A 234
1.74A19.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
ILE A 136
ALA A 173
PHE A 185
HIS A 172
ALA A 194
1.54A19.16
None
None
None
DMS  A 405 ( 4.8A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL E 524
ALA E 363
THR E 430
LEU E 513
ALA E 397
1.31A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6ym0 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL E 524
ALA E 363
THR E 430
LEU E 513
ALA E 397
1.35A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6ym0 HEAVY CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
GLY E 431
VAL E 395
ALA E 363
THR H  31
LEU E 368
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
ILE A 136
ALA A 173
PHE A 185
HIS A 172
ALA A 194
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL A 524
ALA A 363
THR A 430
LEU A 513
ALA A 397
1.30A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6yor SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
VAL E 524
ALA E 363
THR E 430
LEU E 513
ALA E 397
1.30A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
ILE A 136
ALA A 173
PHE A 185
HIS A 172
ALA A 194
1.53A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL E 100
THR E 146
LEU E 109
ALA E 134
ASP E 135
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL A 100
THR A 146
LEU A 109
ALA A 134
ASP A 135
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL C  95
ALA C  39
VAL C  49
HIS C  45
LEU C  53
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL D 100
THR D 146
LEU D 109
ALA D 134
ASP D 135
1.41A
None
None
EDO  D 204 ( 4.5A)
EDO  D 211 (-3.7A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL D  95
ALA D  39
VAL D  49
HIS D  45
LEU D  53
1.38A
None
None
EDO  D 209 (-4.6A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL E 151
ALA E 124
VAL E  95
LEU E 127
ALA E 112
1.35A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL C 151
ALA C 124
VAL C  95
LEU C 127
ALA C 112
1.35A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL B  95
ALA B  39
VAL B  49
HIS B  45
LEU B  53
1.37A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL E  95
ALA E  39
VAL E  49
HIS E  45
LEU E  53
1.37A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL A  95
ALA A  39
VAL A  49
HIS A  45
LEU A  53
1.37A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL A  95
ALA A  39
VAL A  49
HIS A  45
LEU A  53
1.38A
None
None
APR  A 201 (-3.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL B  95
ALA B  39
VAL B  49
HIS B  45
LEU B  53
1.38A
None
None
APR  B 201 (-3.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL D  95
ALA D  39
VAL D  49
HIS D  45
LEU D  53
1.39A
None
None
APR  D 201 (-3.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL E 151
ALA E 124
VAL E  95
LEU E 127
ALA E 112
1.32A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL E  95
ALA E  39
VAL E  49
HIS E  45
LEU E  53
1.37A
None
None
APR  E 201 (-3.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL C  95
ALA C  39
VAL C  49
HIS C  45
LEU C  53
1.38A
None
None
APR  C 201 (-3.6A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL A 151
ALA A 124
VAL A  95
LEU A 127
ALA A 112
1.37A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL C 151
ALA C 124
VAL C  95
LEU C 127
ALA C 112
1.31A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL B  95
ALA B  39
VAL B  49
HIS B  45
LEU B  53
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL A  95
ALA A  39
VAL A  49
HIS A  45
LEU A  53
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL C 100
THR C 146
LEU C 109
ALA C 134
ASP C 135
1.36A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL C  95
ALA C  39
VAL C  49
HIS C  45
LEU C  53
1.37A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
VAL A 100
THR A 146
LEU A 109
ALA A 134
ASP A 135
1.40A
None
None
None
EDO  A 205 (-4.0A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		7bqy MAIN PROTEASE

(SARS-CoV-2;
synthetic
construct)		5 / 12
VAL A 171
ALA A 173
PHE A 185
HIS A 163
ALA C   2
1.58A
None
None
None
PJE  C   5 (-3.8A)
02J  C   1 ( 3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		7bqy MAIN PROTEASE
(SARS-CoV-2)		5 / 12
ILE A 136
ALA A 173
PHE A 185
HIS A 172
ALA A 194
1.55A
None
None
None
PJE  C   5 (-4.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		7btf NSP12
(SARS-CoV-2)		5 / 12
ALA A 878
PHE A 881
HIS A 872
ASP A 833
ALA A 866
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		7btf NSP12
(SARS-CoV-2)		5 / 12
GLY A 670
VAL A 405
ALA A 400
THR A 540
ASP A 390
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		5 / 12
ILE A 136
ALA A 173
PHE A 185
HIS A 172
ALA A 194
1.52A
None
None
None
DMS  A 402 (-4.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
ALA A 878
PHE A 881
HIS A 872
ASP A 833
ALA A 866
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_2
(CYCLIN-DEPENDENT
KINASE 6)		7bv1 NSP12
(SARS-CoV-2)		3 / 3
LYS A 369
GLN A 357
ASN A 356
1.53A17.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		7bv1 NSP12
NSP8
(SARS-CoV-2)		5 / 12
ILE B 107
VAL B 115
ASP B  99
LEU B  98
ALA A 383
1.47A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
VAL A 880
THR A 817
LEU A 869
ALA A 866
ASP A 865
1.54A
None
None
None
None
U  P  18 ( 3.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
ALA A 878
PHE A 881
HIS A 872
ASP A 833
ALA A 866
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		7bv2 NSP12
NSP8
(SARS-CoV-2)		5 / 12
ILE B 107
VAL B 115
ASP B  99
LEU B  98
ALA A 383
1.59A
None