Ligand ID: 2FA


Drugbank ID:
DB01073
(Fludarabine)


Indication:
For the treatment of adult patients with B-cell chronic lymphocytic leukemia (CLL) who have not responded to or whose disease has progressed during treatment with at least one standard alkylating-agent containing regimen

Get human targets for 2FA in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND '2FA'

Click here for results that match SARS-Cov-2 / COVID-19 structures only
Click here for results that match SARS-related structures only


1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_1
(ADENOSYLHOMOCYSTEINA
SE)		1q2w 3C-LIKE PROTEASE
(SARSr-CoV)		5 / 12
HIS A  41
LEU A  27
GLY A 146
HIS A 163
PHE A 181
1.74A21.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_D_2FAD500_2
(ADENOSYLHOMOCYSTEINA
SE)		1ssk NUCLEOCAPSID PROTEIN
(SARSr-CoV)		4 / 4
LEU A 139
GLN A  48
THR A 143
THR A  32
1.80A15.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z35_A_2FAA300_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		1uk3 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
THR A 292
GLY A 109
THR A 199
GLU A 290
GLU A 288
1.70A25.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_C_2FAC308_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		1wof 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 11
SER B   1
GLY A 138
VAL A 171
GLU A 166
SER A 139
1.60A23.28
None
None
None
I12  A1145 (-3.9A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_D_2FAD500_2
(ADENOSYLHOMOCYSTEINA
SE)		1x7q HLA, A-11
(Homo
sapiens)		4 / 4
LEU A  78
GLN A  96
THR A  94
THR A  73
1.58A17.96
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_2
(ADENOSYLHOMOCYSTEINA
SE)		1x7q HLA, A-11
(Homo
sapiens)		4 / 5
LEU A  78
GLN A  96
THR A  94
THR A  73
1.56A17.96
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_D_2FAD500_2
(ADENOSYLHOMOCYSTEINA
SE)		1z1i 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 4
LEU A 202
GLN A 110
THR A 292
THR A 243
1.80A20.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		1z1j 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
LEU B1208
GLY B1275
ASN B1277
LEU B1268
GLY B1278
1.33A20.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_2
(ADENOSYLHOMOCYSTEINA
SE)		1z1j 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 5
GLN B1110
THR B1111
THR B1201
LEU B1250
1.29A20.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_1
(ADENOSYLHOMOCYSTEINA
SE)		1z1j 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
HIS A  41
LEU A  27
GLY A 146
HIS A 163
PHE A 181
1.77A20.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		1zv8 E2 GLYCOPROTEIN
(SARSr-CoV)		5 / 12
LEU D  19
GLY A  28
THR E  23
LEU E  27
ASN F  20
1.23A8.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		2a5i 3C-LIKE PEPTIDASE
(SARSr-CoV)		5 / 12
LEU A 208
GLY A 275
ASN A 277
LEU A 268
GLY A 278
1.10A20.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_1
(ADENOSYLHOMOCYSTEINA
SE)		2a5k 3C-LIKE PEPTIDASE
(SARSr-CoV)		5 / 12
HIS A  41
LEU A  27
GLY A 146
HIS A 163
PHE A 181
1.79A20.52
AZP  A 307 (-3.2A)
AZP  A 307 ( 4.6A)
None
AZP  A 307 (-3.9A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_1
(ADENOSINE KINASE)		2a5k 3C-LIKE PEPTIDASE
(SARSr-CoV)		5 / 12
SER A 139
GLY A 170
GLY B   2
GLN B 299
GLY B 215
1.64A22.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		2ahm REPLICASE
POLYPROTEIN 1AB,
HEAVY CHAIN
REPLICASE
POLYPROTEIN 1AB,
LIGHT CHAIN
(SARSr-CoV)		5 / 12
ASN H 114
LEU H 133
GLY H 118
VAL H 136
GLY D  69
1.27A19.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		2ahm REPLICASE
POLYPROTEIN 1AB,
HEAVY CHAIN
REPLICASE
POLYPROTEIN 1AB,
LIGHT CHAIN
(SARSr-CoV)		5 / 12
LEU D  18
GLY D  69
VAL D  71
LEU D  22
GLY H 118
1.40A13.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		2ajf ACE2
(Homo
sapiens)		5 / 12
LEU A 520
GLY A 448
THR A 519
LEU A 584
GLY A 272
1.34A20.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_A_2FAA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		2ajf ACE2
(Homo
sapiens)		5 / 11
ARG A 219
GLY A 211
VAL A 209
GLU A 208
VAL A 212
1.78A18.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_1
(ADENOSINE KINASE)		2ajf ACE2
SPIKE PROTEIN
(Homo
sapiens;
SARSr-CoV)		5 / 12
GLY F 488
GLY B 354
PHE B 356
ALA B 386
ASP F 392
1.57A21.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_1
(ADENOSYLHOMOCYSTEINA
SE)		2alv REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
HIS A  41
LEU A  27
GLY A 146
HIS A 163
PHE A 181
1.79A20.36
CY6  A1145 (-3.8A)
CY6  A1145 (-4.3A)
None
CY6  A1145 (-3.8A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_1
(ADENOSINE KINASE)		2amd 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
SER A   1
GLY A  -1
ASN A 214
GLY A 215
ASP A 216
1.61A22.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_A_2FAA306_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		2amd 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
SER B   1
GLY A 138
VAL A 171
GLU A 166
SER A 139
1.61A23.28
None
None
None
9IN  A1001 (-4.1A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		2beq SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
LEU D1168
GLY C 928
THR B 923
LEU B 927
ASN E1169
1.27A8.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		2beq SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
LEU A 944
GLY E1153
VAL C 945
LEU B 941
ASP E1150
1.32A6.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_C_2FAC308_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		2cjr NUCLEOCAPSID PROTEIN
(SARS-COV
TW1)		5 / 11
GLY B 329
VAL B 325
GLU B 324
MET B 323
ASP A 342
1.41A18.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_2
(ADENOSINE KINASE)		2cjr NUCLEOCAPSID PROTEIN
(SARS-COV
TW1)		4 / 5
LEU F 332
ALA E 309
MET E 318
PHE F 315
1.42A16.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_B_2FAB301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		2cjr NUCLEOCAPSID PROTEIN
(SARS-COV
TW1)		5 / 12
GLY B 329
VAL B 325
GLU B 324
MET B 323
ASP A 342
1.25A23.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_A_2FAA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		2cjr NUCLEOCAPSID PROTEIN
(SARS-COV
TW1)		5 / 11
GLY B 329
VAL B 325
GLU B 324
MET B 323
ASP A 342
1.24A23.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_A_2FAA306_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		2cjr NUCLEOCAPSID PROTEIN
(SARS-COV
TW1)		5 / 10
GLY B 329
VAL B 325
GLU B 324
MET B 323
ASP A 342
1.36A18.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		2cme HYPOTHETICAL PROTEIN
5
(SARSr-CoV)		5 / 12
LEU B  22
ASN B  52
VAL B  16
LEU A  22
GLY B  50
1.39A12.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_2
(ADENOSINE KINASE)		2cme HYPOTHETICAL PROTEIN
5
(SARSr-CoV)		4 / 5
LEU B  55
ILE A  46
ALA B  58
PHE A  92
1.60A12.85
D10  B1099 ( 4.6A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_2
(ADENOSINE KINASE)		2cme HYPOTHETICAL PROTEIN
5
(SARSr-CoV)		4 / 5
LEU G  55
ILE H  46
ALA G  58
PHE H  92
1.53A12.85
D10  H1099 ( 4.8A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_2
(ADENOSINE KINASE)		2cme HYPOTHETICAL PROTEIN
5
(SARSr-CoV)		4 / 5
LEU A  55
ILE B  46
ALA A  58
PHE B  92
1.64A12.85
D10  B1099 ( 4.2A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_2
(ADENOSINE KINASE)		2cme HYPOTHETICAL PROTEIN
5
(SARSr-CoV)		4 / 5
LEU H  55
ILE G  46
ALA H  58
PHE G  92
1.60A12.10
D10  H1099 ( 4.6A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_2
(ADENOSYLHOMOCYSTEINA
SE)		2d2d 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 5
GLN B 110
THR B 111
THR B 201
LEU B 250
1.18A21.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_1
(ADENOSYLHOMOCYSTEINA
SE)		2d2d 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
HIS B  41
LEU B  27
GLY B 146
HIS B 163
PHE B 181
1.33A21.01
ENB  B1145 (-3.4A)
ENB  B1145 (-4.2A)
None
ENB  B1145 (-3.7A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_D_2FAD500_1
(ADENOSYLHOMOCYSTEINA
SE)		2d2d 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
HIS B  41
THR B  25
ASP B 187
HIS B 164
LEU B  27
1.68A21.01
ENB  B1145 (-3.4A)
ENB  B1145 ( 4.7A)
None
None
ENB  B1145 (-4.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_1
(ADENOSINE KINASE)		2dd8 IGG LIGHT CHAIN
(Homo
sapiens)		5 / 12
SER L  30
GLY L  68
GLY L  29
ASN L  66
ASP L  51
1.59A19.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_1
(ADENOSINE KINASE)		2dd8 IGG LIGHT CHAIN
(Homo
sapiens)		5 / 12
SER L  30
GLY L  68
GLY L  29
ASN L  66
ASP L  51
1.57A19.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_2
(ADENOSINE KINASE)		2dd8 SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 5
LEU S 374
ILE S 345
ALA S 350
PHE S 325
1.65A20.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_1
(ADENOSINE KINASE)		2dd8 IGG HEAVY CHAIN
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARSr-CoV)		5 / 12
ASP H  95
GLY H  50
ALA H  60
GLY S 490
ASP S 392
1.16A18.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_1
(ADENOSINE KINASE)		2fav REPLICASE
POLYPROTEIN 1AB
(PP1AB) (ORF1AB)
(SARSr-CoV)		5 / 12
GLY A  48
GLY A  49
PHE A 133
ALA A 130
ASP B 121
1.68A19.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		2fav REPLICASE
POLYPROTEIN 1AB
(PP1AB) (ORF1AB)
(SARSr-CoV)		5 / 12
ASN C  55
GLY C  49
GLY C  48
ASN B 102
GLY B 134
1.20A20.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_1
(ADENOSINE KINASE)		2fav REPLICASE
POLYPROTEIN 1AB
(PP1AB) (ORF1AB)
(SARSr-CoV)		5 / 12
SER C 129
ASN C 100
ALA C 135
GLN C 139
GLY C 104
1.62A19.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z35_A_2FAA300_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		2fe8 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 10
THR B  43
GLY B  33
THR B  10
VAL B  58
SER C  67
1.48A19.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_2
(ADENOSYLHOMOCYSTEINA
SE)		2fyg REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 5
GLN A  53
THR A  56
THR A  47
HIS A  48
1.64A12.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 12
ASN T 114
GLY T 127
THR T 102
ASN T  62
GLY T  52
1.38A17.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_2
(ADENOSYLHOMOCYSTEINA
SE)		2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 5
GLN B  53
THR B  56
THR B  47
HIS B  48
1.53A13.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_1
(ADENOSYLHOMOCYSTEINA
SE)		2gdt NSP1 (EC 3.4.22.-)
P65 HOMOLOG
LEADER PROTEIN
(SARSr)		5 / 12
LEU A  66
THR A  68
ASP A  64
GLY A  71
HIS A  70
1.41A13.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_1
(ADENOSYLHOMOCYSTEINA
SE)		2gdt NSP1 (EC 3.4.22.-)
P65 HOMOLOG
LEADER PROTEIN
(SARSr)		5 / 12
LEU A  66
HIS A  70
LYS A   1
GLY A  71
HIS A  72
1.20A13.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_2
(ADENOSINE KINASE)		2ghv SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 5
LEU E 374
ILE C 345
ALA C 350
PHE C 325
1.77A20.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z35_A_2FAA300_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		2gib NUCLEOCAPSID PROTEIN
(SARSr-CoV)		5 / 10
GLY A 329
VAL A 325
GLU A 324
MET A 323
SER A 328
1.79A16.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_B_2FAB301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		2gib NUCLEOCAPSID PROTEIN
(SARSr-CoV)		5 / 12
GLY A 329
VAL A 325
GLU A 324
MET A 323
ASP B 342
1.69A17.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_A_2FAA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		2gib NUCLEOCAPSID PROTEIN
(SARSr-CoV)		5 / 11
GLY A 329
VAL A 325
GLU A 324
MET A 323
ASP B 342
1.65A17.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_A_2FAA306_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		2gib NUCLEOCAPSID PROTEIN
(SARSr-CoV)		5 / 10
GLY A 329
VAL A 325
GLU A 324
MET A 323
SER A 328
1.77A15.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_2
(ADENOSINE KINASE)		2gib NUCLEOCAPSID PROTEIN
(SARSr-CoV)		4 / 5
LEU A 332
ALA B 309
MET B 318
PHE A 315
1.73A13.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_D_2FAD500_2
(ADENOSYLHOMOCYSTEINA
SE)		2gt8 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 4
LEU A 202
GLN A 110
THR A 292
THR A 243
1.79A20.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z35_A_2FAA300_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		2gt8 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
THR A 111
GLY A 109
THR A 199
GLU A 290
GLU A 288
1.70A24.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_2
(ADENOSYLHOMOCYSTEINA
SE)		2gtb 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 5
GLN A 110
THR A 111
THR A 201
LEU A 250
1.21A20.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		2gtb 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
LEU A 208
GLY A 275
ASN A 277
LEU A 268
GLY A 278
1.36A20.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_D_2FAD500_2
(ADENOSYLHOMOCYSTEINA
SE)		2jzd REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 4
LEU A 533
GLN A 561
THR A 559
THR A 605
1.70A15.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_2
(ADENOSYLHOMOCYSTEINA
SE)		2jzd REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 5
LEU A 533
GLN A 561
THR A 559
THR A 605
1.68A15.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_D_2FAD500_2
(ADENOSYLHOMOCYSTEINA
SE)		2jzf REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 4
LEU A 533
GLN A 561
THR A 559
THR A 605
1.75A16.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_2
(ADENOSYLHOMOCYSTEINA
SE)		2jzf REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		4 / 5
LEU A 533
GLN A 561
THR A 559
THR A 605
1.70A16.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_2
(ADENOSYLHOMOCYSTEINA
SE)		2ofz NUCLEOCAPSID PROTEIN
(SARS-COV
Tor2)		4 / 5
LEU A 168
GLN A 161
THR A  58
HIS A  60
1.52A14.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_2
(ADENOSYLHOMOCYSTEINA
SE)		2op9 REPLICASE
POLYPROTEIN 1AB
(PP1AB, ORF1AB)
3C-LIKE PROTEINASE
(3CL-PRO, 3CLP)
(SARSr-CoV)		4 / 5
GLN B 110
THR B 111
THR B 201
LEU B 250
1.25A20.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_1
(ADENOSYLHOMOCYSTEINA
SE)		2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 12
ASP D 282
ASP D 239
LEU D 254
GLY D 253
HIS D 249
1.80A22.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 12
LEU B 263
GLY B 246
GLY B 247
LEU B 254
GLY D 247
1.11A19.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_D_2FAD500_1
(ADENOSYLHOMOCYSTEINA
SE)		2pwx 3C-LIKE PROTEINASE
(SARS-COV
BJ01)		5 / 12
THR A  25
ASP A 187
HIS A 163
LEU A  27
MET A  49
1.73A20.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_1
(ADENOSYLHOMOCYSTEINA
SE)		2q6g REPLICASE
POLYPROTEIN 1AB
(SARS-COV
BJ01)		5 / 12
ASP B 187
LEU B  27
GLY B 146
HIS B 163
PHE B 181
1.79A20.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_1
(ADENOSINE KINASE)		2q6g POLYPEPTIDE CHAIN
REPLICASE
POLYPROTEIN 1AB
(SARS-COV
BJ01)		5 / 12
SER B 147
GLY B 146
PHE B 140
ALA B 116
GLY D   8
1.45A22.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z35_A_2FAA300_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		2q6g REPLICASE
POLYPROTEIN 1AB
(SARS-COV
BJ01)		5 / 10
GLY B 138
THR B 169
VAL B 171
GLU B 166
SER B 139
1.78A25.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_2
(ADENOSYLHOMOCYSTEINA
SE)		2q6g REPLICASE
POLYPROTEIN 1AB
(SARS-COV
BJ01)		4 / 5
GLN B 110
THR B 111
THR B 201
LEU B 250
1.18A20.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_2
(ADENOSYLHOMOCYSTEINA
SE)		2qc2 3C-LIKE PROTEINASE
(-)		4 / 5
GLN A 110
THR A 111
THR A 201
LEU A 250
1.17A20.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_1
(ADENOSINE KINASE)		2qc2 3C-LIKE PROTEINASE
(-)		5 / 12
SER A 144
GLY A 143
ASN A 142
ALA A 116
GLY B 302
1.41A22.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z35_A_2FAA300_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		2qc2 3C-LIKE PROTEINASE
(-)		5 / 10
THR A 292
GLY A 109
THR A 199
GLU A 290
GLU A 288
1.65A25.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_2
(ADENOSINE KINASE)		2qcy 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 4
ALA A 210
VAL A 297
PHE A   3
THR A 292
1.79A22.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_D_2FAD500_1
(ADENOSYLHOMOCYSTEINA
SE)		2qcy 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
THR A  25
ASP A 187
HIS A 163
LEU A  27
MET A  49
1.76A20.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_1
(ADENOSYLHOMOCYSTEINA
SE)		2qcy 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
HIS A  41
LEU A  27
GLY A 146
HIS A 163
PHE A 181
1.24A20.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_1
(ADENOSYLHOMOCYSTEINA
SE)		2qcy 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
HIS A  41
LEU A  27
GLY A 146
HIS A 163
PHE A 181
1.24A20.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_1
(ADENOSYLHOMOCYSTEINA
SE)		2qiq REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
HIS A  41
LEU A  27
GLY A 146
HIS A 163
PHE A 181
1.79A20.12
CYV  A 302 ( 3.8A)
CYV  A 302 ( 4.3A)
None
CYV  A 302 (-3.9A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_1
(ADENOSYLHOMOCYSTEINA
SE)		2rhb URIDYLATE-SPECIFIC
ENDORIBONUCLEASE
(SARSr-CoV)		5 / 12
LEU A  57
THR A  98
GLU A  56
LYS A   0
GLY A 100
1.49A22.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_2
(ADENOSYLHOMOCYSTEINA
SE)		2vj1 MAIN PROTEINASE
(SARSr-CoV)		4 / 5
GLN B 110
THR B 111
THR B 201
LEU B 250
1.27A20.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_1
(ADENOSYLHOMOCYSTEINA
SE)		2vj1 MAIN PROTEINASE
(SARSr-CoV)		5 / 12
HIS A  41
LEU A  27
GLY A 146
HIS A 163
PHE A 181
1.34A20.16
BEZ  A1303 (-3.4A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_D_2FAD500_1
(ADENOSYLHOMOCYSTEINA
SE)		2vj1 MAIN PROTEINASE
(SARSr-CoV)		5 / 12
THR A  25
ASP A 187
HIS A 163
LEU A  27
MET A  49
1.76A20.16
None
None
None
None
BEZ  A1303 (-3.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_B_2FAB301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		2xyq NSP10
PUTATIVE 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		5 / 12
ARG B  78
SER A  74
GLY A  81
VAL A  44
VAL A  84
1.74A17.86
None
SAH  A1293 (-4.1A)
SAH  A1293 (-3.6A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_1
(ADENOSINE KINASE)		2xyq PUTATIVE 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		5 / 12
SER A 166
GLY A 164
GLY A 165
ASN A 210
GLY A 278
1.65A21.75
 NA  A1295 (-2.7A)
None
NA  A1295 (-3.8A)
NA  A1295 (-4.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_2
(ADENOSYLHOMOCYSTEINA
SE)		2xyq PUTATIVE 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		4 / 5
LEU A  89
THR A  93
THR A  82
HIS A  69
1.65A21.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_2
(ADENOSYLHOMOCYSTEINA
SE)		2xyr PUTATIVE 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		4 / 5
LEU A  89
THR A  93
THR A  82
HIS A  69
1.64A21.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_2
(ADENOSINE KINASE)		2xyr NSP10
PUTATIVE 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		4 / 4
ALA B  71
VAL A  78
GLY A  81
THR A  82
1.21A15.20
None
None
SFG  A1298 (-3.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_1
(ADENOSINE KINASE)		2xyr PUTATIVE 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		5 / 12
SER A 166
GLY A 164
GLY A 165
ASN A 210
GLY A 278
1.63A21.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_2
(ADENOSYLHOMOCYSTEINA
SE)		2xyr NSP10
(SARSr-CoV)		4 / 5
GLN B  53
THR B  56
THR B  47
HIS B  48
1.60A12.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_2
(ADENOSINE KINASE)		2xyv NSP10
PUTATIVE 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		4 / 4
ALA B  71
VAL A  78
GLY A  81
THR A  82
1.21A15.20
None
None
SAH  A1300 (-3.9A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_B_2FAB301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		2xyv NSP10
PUTATIVE 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		5 / 12
ARG B  78
SER A  74
GLY A  81
VAL A  44
VAL A  84
1.70A17.86
None
SAH  A1300 (-4.2A)
SAH  A1300 (-3.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_2
(ADENOSYLHOMOCYSTEINA
SE)		2xyv NSP10
(SARSr-CoV)		4 / 5
GLN B  53
THR B  56
THR B  47
HIS B  48
1.66A12.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_B_2FAB301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		2z9j 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
SER B   1
GLY A 138
VAL A 171
GLU A 166
SER A 139
1.71A21.79
None
None
None
DMS  A 804 (-4.1A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_1
(ADENOSINE KINASE)		2z9k 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
SER B 147
GLY B 143
PHE B 140
ALA B 116
GLY A 302
1.65A22.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_2
(ADENOSYLHOMOCYSTEINA
SE)		3aw0 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 5
GLN A 110
THR A 111
THR A 201
LEU A 250
1.22A20.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_D_2FAD500_1
(ADENOSYLHOMOCYSTEINA
SE)		3aw1 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
THR A  25
ASP A 187
HIS A 163
LEU A  27
MET A  49
1.79A20.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_A_2FAA306_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		3bgf F26G19 FAB
(Mus
musculus)		5 / 10
SER H  82
VAL H  18
GLU H  81
MET H  80
SER H  82
1.73A19.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z35_A_2FAA300_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		3bgf F26G19 FAB
(Mus
musculus)		5 / 10
ARG H  33
THR H  58
GLY H  49
THR H  93
GLU H  95
1.76A21.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_1
(ADENOSINE KINASE)		3bgf F26G19 FAB
SPIKE PROTEIN S1
(Mus
musculus;
SARSr-CoV)		5 / 12
ASP A 392
GLY A 490
GLY A 391
ALA A 422
GLY B  96
1.41A20.96
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_C_2FAC308_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		3bgf F26G19 FAB
(Mus
musculus)		5 / 11
SER B  82
VAL B  18
GLU B  81
MET B  80
ASP B  86
1.73A19.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		3bgf F26G19 FAB
SPIKE PROTEIN S1
(Mus
musculus;
SARSr-CoV)		5 / 12
ASP A 392
LEU B 100
GLY A 490
GLY A 488
THR B 100
1.31A19.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_B_2FAB301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		3bgf F26G19 FAB
(Mus
musculus)		5 / 12
SER H 162
GLY H 164
VAL H 183
SER H 163
VAL H 185
1.77A22.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_1
(ADENOSINE KINASE)		3d0g ACE2
SPIKE GLYCOPROTEIN
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 12
GLY E 488
GLY A 354
PHE A 356
ALA A 386
ASP E 392
1.43A21.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_2
(ADENOSYLHOMOCYSTEINA
SE)		3d0g ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 5
LEU B 370
GLN B 522
THR B 414
HIS B 417
1.65A20.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_1
(ADENOSINE KINASE)		3d0h ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 12
SER B  40
ASP B 350
ALA B  36
GLN B  37
GLY B 354
1.43A20.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		3d0h ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 12
LEU A 520
GLY A 448
THR A 519
LEU A 584
GLY A 272
1.38A20.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_1
(ADENOSINE KINASE)		3d0h ACE2
SPIKE GLYCOPROTEIN
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 12
GLY E 488
GLY A 354
PHE A 356
ALA A 386
ASP E 392
1.41A21.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_1
(ADENOSINE KINASE)		3d0i ACE2
SPIKE GLYCOPROTEIN
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 12
GLY E 488
GLY A 354
PHE A 356
ALA A 386
ASP E 392
1.39A21.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_2
(ADENOSINE KINASE)		3d0i ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 5
LEU A 320
ILE A 407
ALA A 550
MET A 408
1.41A20.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_1
(ADENOSYLHOMOCYSTEINA
SE)		3d62 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
HIS A  41
LEU A  27
GLY A 146
HIS A 163
PHE A 181
1.78A19.92
959  A 350 (-3.9A)
959  A 350 ( 4.8A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_2
(ADENOSYLHOMOCYSTEINA
SE)		3d62 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 5
GLN A 110
THR A 111
THR A 201
LEU A 250
1.25A19.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		3d62 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
LEU A 208
GLY A 275
ASN A 277
LEU A 268
GLY A 278
1.32A20.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_1
(ADENOSINE KINASE)		3e91 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
SER B 147
GLY B 143
PHE B 140
ALA B 116
GLY A 302
1.62A22.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_2
(ADENOSYLHOMOCYSTEINA
SE)		3e91 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 5
GLN A 110
THR A 111
THR A 201
LEU A 250
1.16A19.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_1
(ADENOSYLHOMOCYSTEINA
SE)		3ea7 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
HIS A  41
LEU A  27
GLY A 146
HIS A 163
PHE A 181
1.76A19.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_2
(ADENOSINE KINASE)		3ea9 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 4
ALA A 210
VAL A 297
PHE A   3
THR A 292
1.79A22.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_1
(ADENOSYLHOMOCYSTEINA
SE)		3ea9 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
HIS A  41
LEU A  27
GLY A 146
HIS A 163
PHE A 181
1.75A19.96
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		3eaj 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
LEU A 242
GLY B 195
THR A 243
LEU A 227
GLY B 183
1.29A20.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_2
(ADENOSYLHOMOCYSTEINA
SE)		3eaj 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 5
GLN B 110
THR B 111
THR B 201
LEU B 250
1.26A19.96
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		3ee7 REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		5 / 12
ASN A  98
GLY A  93
LEU A  42
GLY C  61
ASP C  60
1.21A13.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_1
(ADENOSINE KINASE)		3ee7 REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		5 / 12
ASP C  60
GLY C  61
GLY C  63
ALA A  54
GLY A  93
1.46A16.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_D_2FAD500_1
(ADENOSYLHOMOCYSTEINA
SE)		3f9e 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
HIS A  41
LEU A  27
GLY A 146
HIS A 163
PHE A 181
1.30A20.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_1
(ADENOSYLHOMOCYSTEINA
SE)		3f9e 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
HIS A  41
LEU A  27
GLY A 146
HIS A 163
PHE A 181
1.21A20.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_1
(ADENOSYLHOMOCYSTEINA
SE)		3f9e 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
HIS A  41
LEU A  27
GLY A 146
HIS A 163
PHE A 181
1.21A20.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_2
(ADENOSYLHOMOCYSTEINA
SE)		3f9f 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 5
GLN A 110
THR A 111
THR A 201
LEU A 250
1.19A20.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_2
(ADENOSINE KINASE)		3f9g 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 4
ALA B 267
VAL B 261
PHE B 230
THR B 225
1.80A19.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_2
(ADENOSYLHOMOCYSTEINA
SE)		3f9g 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 5
GLN B 110
THR B 111
THR B 201
LEU B 250
1.20A20.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_2
(ADENOSYLHOMOCYSTEINA
SE)		3f9g 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 5
LEU A  50
GLN A 192
THR A 190
THR A  45
1.64A20.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z35_A_2FAA300_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		3f9h 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
THR B 111
GLY B 109
THR B 199
GLU B 290
GLU B 288
1.78A25.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_D_2FAD500_1
(ADENOSYLHOMOCYSTEINA
SE)		3f9h 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
THR B  25
ASP B 187
HIS B 163
LEU B  27
MET B  49
1.78A20.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_1
(ADENOSYLHOMOCYSTEINA
SE)		3f9h 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
HIS B  41
LEU B  27
GLY B 146
HIS B 163
PHE B 181
1.74A20.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_2
(ADENOSYLHOMOCYSTEINA
SE)		3fzd 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 5
GLN A 110
THR A 111
THR A 201
LEU A 250
1.23A19.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_2
(ADENOSYLHOMOCYSTEINA
SE)		3i6g HLA, A-2
(Homo
sapiens)		4 / 5
LEU A 230
GLN A 224
THR A 228
THR A 214
1.30A18.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_D_2FAD500_2
(ADENOSYLHOMOCYSTEINA
SE)		3i6g HLA, A-2
(Homo
sapiens)		4 / 4
LEU A 230
GLN A 224
THR A 228
THR A 214
1.31A18.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_2
(ADENOSYLHOMOCYSTEINA
SE)		3i6l HLA, A-24
(Homo
sapiens)		4 / 5
LEU D  78
GLN D  96
THR D  94
THR D  73
1.58A19.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_1
(ADENOSYLHOMOCYSTEINA
SE)		3iwm 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
HIS A  41
LEU A  27
GLY A 146
HIS A 163
PHE A 181
1.25A20.16
PJE  H   5 (-4.9A)
PJE  H   5 (-4.4A)
None
PJE  H   5 (-4.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_1
(ADENOSYLHOMOCYSTEINA
SE)		3m3s 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
HIS B  41
LEU B  27
GLY B 146
HIS B 163
PHE B 181
1.75A20.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_2
(ADENOSYLHOMOCYSTEINA
SE)		3m3s 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 5
GLN B 110
THR B 111
THR B 201
LEU B 250
1.24A20.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_1
(ADENOSYLHOMOCYSTEINA
SE)		3m3t 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
HIS A  41
LEU A  27
GLY A 146
HIS A 163
PHE A 181
1.26A21.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_1
(ADENOSINE KINASE)		3m3t 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
SER A 284
GLY A   2
GLY A 283
GLY A  -1
ASP A 216
1.65A22.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_1
(ADENOSYLHOMOCYSTEINA
SE)		3m3t 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
HIS A  41
LEU A  27
GLY A 146
HIS A 163
PHE A 181
1.26A21.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z35_A_2FAA300_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		3m3v 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
THR A 292
GLY A 109
THR A 199
GLU A 290
GLU A 288
1.78A23.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_2
(ADENOSYLHOMOCYSTEINA
SE)		3m3v 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 5
GLN A 110
THR A 111
THR A 201
LEU A 250
1.26A20.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_1
(ADENOSYLHOMOCYSTEINA
SE)		3m3v 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
HIS B  41
LEU B  27
GLY B 146
HIS B 163
PHE B 181
1.27A20.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_1
(ADENOSYLHOMOCYSTEINA
SE)		3m3v 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
HIS B  41
LEU B  27
GLY B 146
HIS B 163
PHE B 181
1.28A20.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_1
(ADENOSINE KINASE)		3m3v 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
SER B 147
GLY B 143
PHE B 140
ALA B 116
GLY A 302
1.56A22.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_2
(ADENOSINE KINASE)		3m3v 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 4
ALA A 267
VAL A 261
PHE A 230
THR A 225
1.78A22.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z35_A_2FAA300_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		3mj5 REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		5 / 10
GLY A 202
THR A 171
VAL A 203
GLU A 204
SER B  79
1.56A19.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		3mj5 REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		5 / 12
LEU B 119
GLY B 164
VAL B 166
LEU B 118
GLY B 272
1.42A19.59
None
GRM  B 801 (-3.9A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_2
(ADENOSYLHOMOCYSTEINA
SE)		3r24 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		4 / 5
LEU A  89
THR A  93
THR A  82
HIS A  69
1.65A21.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_2
(ADENOSINE KINASE)		3r24 2'-O-METHYL
TRANSFERASE
NSP10 AND NSP11
(SARSr-CoV)		4 / 4
ALA B  71
VAL A  78
GLY A  81
THR A  82
1.21A19.21
None
None
SAM  A 302 (-3.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_1
(ADENOSINE KINASE)		3r24 2'-O-METHYL
TRANSFERASE
(SARSr-CoV)		5 / 12
SER A 166
GLY A 164
GLY A 165
ASN A 210
GLY A 278
1.59A20.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_2
(ADENOSYLHOMOCYSTEINA
SE)		3r24 NSP10 AND NSP11
(SARSr-CoV)		4 / 5
GLN B  53
THR B  56
THR B  47
HIS B  48
1.62A13.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_1
(ADENOSINE KINASE)		3sci ACE2
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARSr-CoV)		5 / 12
GLY F 488
GLY B 354
PHE B 356
ALA B 386
ASP F 392
1.54A20.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_1
(ADENOSINE KINASE)		3scj ACE2
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARSr-CoV)		5 / 12
GLY E 488
GLY A 354
PHE A 356
ALA A 387
ASP E 392
1.69A20.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_2
(ADENOSINE KINASE)		3sck ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 5
LEU B 320
ILE B 407
ALA B 550
MET B 408
1.65A19.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		3sck ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 12
LEU B 520
GLY B 448
THR B 519
LEU B 584
GLY B 272
1.32A19.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_1
(ADENOSINE KINASE)		3sck ACE2
SPIKE GLYCOPROTEIN
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 12
GLY E 488
GLY A 354
PHE A 356
ALA A 386
ASP E 392
1.46A20.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_2
(ADENOSYLHOMOCYSTEINA
SE)		3scl ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		4 / 5
LEU B 370
GLN B 522
THR B 414
HIS B 417
1.52A20.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_1
(ADENOSINE KINASE)		3scl ACE2
SPIKE GLYCOPROTEIN
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 12
GLY E 488
GLY A 354
PHE A 356
ALA A 386
ASP E 392
1.44A20.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_1
(ADENOSINE KINASE)		3scl ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 12
ASP B 206
ASN B 394
ALA B  99
GLN B  98
GLY B 395
1.45A20.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_1
(ADENOSYLHOMOCYSTEINA
SE)		3sna 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
HIS A  41
LEU A  27
GLY A 146
HIS A 163
PHE A 181
1.77A20.12
ECC  H   5 ( 4.3A)
ECC  H   5 ( 4.9A)
None
ECC  H   5 ( 4.1A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_D_2FAD500_1
(ADENOSYLHOMOCYSTEINA
SE)		3snb 3C-LIKE PROTEINASE
PEPTIDE ALDEHYDE
INHIBITOR AC-DSFDQ-H
(SARSr-CoV)		5 / 12
HIS A  41
ASP H   4
GLY A 146
HIS A 163
PHE A 181
1.35A20.16
ECC  H   5 ( 4.9A)
None
None
ECC  H   5 ( 3.9A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_1
(ADENOSYLHOMOCYSTEINA
SE)		3snb 3C-LIKE PROTEINASE
PEPTIDE ALDEHYDE
INHIBITOR AC-DSFDQ-H
(SARSr-CoV)		5 / 12
HIS A  41
ASP H   4
GLY A 146
HIS A 163
PHE A 181
1.27A20.16
ECC  H   5 ( 4.9A)
None
None
ECC  H   5 ( 3.9A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_2
(ADENOSYLHOMOCYSTEINA
SE)		3vb3 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 5
GLN B 110
THR B 111
THR B 201
LEU B 250
1.14A20.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z35_A_2FAA300_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		4hi3 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
THR B 111
GLY B 109
THR B 199
GLU B 290
GLU B 288
1.73A24.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_1
(ADENOSYLHOMOCYSTEINA
SE)		4hi3 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
HIS B  41
LEU B  27
GLY B 146
HIS B 163
PHE B 181
1.74A20.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		4m0w REPLICASE
POLYPROTEIN 1A
UBIQUITIN
(Bos
taurus;
SARSr-CoV)		5 / 12
ASN A 111
LEU A 118
GLY B  75
GLY B  76
VAL A 166
1.39A19.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_2
(ADENOSYLHOMOCYSTEINA
SE)		4mds 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 5
GLN A 110
THR A 111
THR A 201
LEU A 250
1.23A20.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_1
(ADENOSYLHOMOCYSTEINA
SE)		4mds 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
HIS A  41
LEU A  27
GLY A 146
HIS A 163
PHE A 181
1.74A20.63
23H  A 401 (-3.7A)
None
None
23H  A 401 (-4.1A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_A_2FAA306_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		4mm3 PAPAIN-LIKE
PROTEINASE
UBIQUITIN
(Homo
sapiens;
SARSr-CoV)		5 / 10
ARG A  42
VAL B 166
GLU B 168
SER B 246
ASP B 303
1.78A15.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_C_2FAC308_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		4mm3 PAPAIN-LIKE
PROTEINASE
UBIQUITIN
(Homo
sapiens;
SARSr-CoV)		5 / 11
ARG A  42
VAL B 166
GLU B 168
SER B 246
ASP B 303
1.79A15.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_C_2FAC308_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		4ovz PAPAIN-LIKE
PROTEINASE
(SARS-COV
Urbani)		6 / 11
GLY B 202
VAL B 203
GLU B 204
GLU A 162
SER A  79
ASP A  77
1.70A19.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_B_2FAB301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		4ovz PAPAIN-LIKE
PROTEINASE
(SARS-COV
Urbani)		6 / 12
GLY B 202
VAL B 203
GLU B 204
GLU A 162
SER A  79
ASP A  77
1.62A23.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_B_2FAB307_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		4ovz PAPAIN-LIKE
PROTEINASE
(SARS-COV
Urbani)		5 / 9
GLY B 202
GLU B 204
GLU A 162
SER A  79
ASP A  77
1.65A19.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_A_2FAA306_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		4ovz PAPAIN-LIKE
PROTEINASE
(SARS-COV
Urbani)		6 / 10
GLY B 202
VAL B 203
GLU B 204
GLU A 162
SER A  79
ASP A  77
1.65A19.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_A_2FAA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		4ovz PAPAIN-LIKE
PROTEINASE
(SARS-COV
Urbani)		6 / 11
GLY B 202
VAL B 203
GLU B 204
GLU A 162
SER A  79
ASP A  77
1.59A23.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_2
(ADENOSINE KINASE)		4rna PAPAIN-LIKE PROTEASE
(Human
betacoronavirus
2c
EMC/2012)		4 / 4
ALA A  38
VAL A  33
PHE A  35
THR A  43
1.61A23.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_1
(ADENOSYLHOMOCYSTEINA
SE)		4tww 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
HIS B  41
LEU B  27
GLY B 146
HIS B 163
PHE B 181
1.72A20.16
3A7  B 401 ( 4.1A)
None
None
3A7  B 401 (-4.0A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_2
(ADENOSINE KINASE)		4tww 3C-LIKE PROTEINASE
(SARSr-CoV)		4 / 5
LEU B 205
ILE B 259
ALA B 267
PHE B 219
1.72A20.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z35_A_2FAA300_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		4twy 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 10
THR A 111
GLY A 109
THR A 199
GLU A 290
GLU A 288
1.71A25.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_1
(ADENOSYLHOMOCYSTEINA
SE)		5b6o 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
HIS B  41
LEU B  27
GLY B 146
HIS B 163
PHE B 181
1.77A20.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		5c5o 3C-LIKE PROTEINASE
(SARSr-CoV)		5 / 12
GLY A   2
ASN A 214
VAL B 171
GLY A 215
ASP A 216
1.41A20.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_2
(ADENOSINE KINASE)		5c8s GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		4 / 5
LEU B 174
ILE B 166
MET B 169
PHE B 183
1.77A21.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_2
(ADENOSYLHOMOCYSTEINA
SE)		5c8s GUANINE-N7
METHYLTRANSFERASE
NSP10
(SARSr-CoV)		4 / 5
LEU B  54
THR B 103
THR B 131
HIS A  80
1.68A23.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_2
(ADENOSINE KINASE)		5c8s GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		4 / 4
ALA B 425
VAL B 282
GLY B 417
THR B 428
1.52A21.22
None
None
None
G3A  B 606 (-3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_2
(ADENOSINE KINASE)		5c8t GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		4 / 5
LEU B 174
ILE B 166
MET B 169
PHE B 183
1.77A21.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_2
(ADENOSYLHOMOCYSTEINA
SE)		5c8u GUANINE-N7
METHYLTRANSFERASE
NSP10
(SARSr-CoV)		4 / 5
LEU D  54
THR D 103
THR D 131
HIS C  80
1.67A23.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_1
(ADENOSINE KINASE)		5c8u NSP10
(SARSr-CoV)		5 / 12
GLY C  94
ALA C  54
GLN C  98
GLN C  53
GLY C  69
1.30A18.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_2
(ADENOSYLHOMOCYSTEINA
SE)		5c8u NSP10
(SARSr-CoV)		4 / 5
GLN A  53
THR A  56
THR A  47
HIS A  48
1.46A13.46
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		5c8u GUANINE-N7
METHYLTRANSFERASE
(SARSr-CoV)		5 / 12
GLY B 110
ASN B 116
THR B 277
LEU B 185
GLY B 114
1.32A21.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_2
(ADENOSYLHOMOCYSTEINA
SE)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		4 / 5
GLN M  53
THR M  56
THR M  47
HIS M  48
1.65A13.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_2
(ADENOSYLHOMOCYSTEINA
SE)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		4 / 5
LEU C  54
THR C 103
THR C 131
HIS P  80
1.70A23.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_1
(ADENOSINE KINASE)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		5 / 12
GLY P  94
ALA P  54
GLN P  98
GLN P  53
GLY P  69
1.50A16.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z35_A_2FAA300_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		5 / 10
ARG A 289
THR A 428
GLY A 413
VAL A 282
SER A 418
1.55A18.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_2
(ADENOSINE KINASE)		5nfy POLYPROTEIN 1AB
(SARS-COV
Frankfurt
1)		4 / 5
LEU A 174
ILE A 166
MET A 169
PHE A 183
1.70A22.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_1
(ADENOSYLHOMOCYSTEINA
SE)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
HIS A  41
LEU A  27
GLY A 146
HIS A 163
PHE A 181
1.79A14.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
LEU A 205
VAL A 296
LEU A 250
ASN A 214
GLY A 215
1.67A18.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_2
(ADENOSINE KINASE)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 4
ALA A 206
VAL A 261
GLY A 258
THR A 257
1.73A18.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_2
(ADENOSYLHOMOCYSTEINA
SE)		5rfc 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 5
GLN A 110
THR A 111
THR A 201
LEU A 250
1.44A14.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		5tl6 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 12
LEU D 260
GLY D 101
ASN B  16
THR D 278
ASP B  13
1.21A20.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_B_2FAB301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		5tl7 REPLICASE
POLYPROTEIN 1AB
UBIQUITIN-LIKE
PROTEIN ISG15
(Mus
musculus;
SARSr-CoV)		5 / 12
ARG C  85
GLY C 126
GLU C 125
SER C 123
VAL D 203
1.67A15.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_2
(ADENOSYLHOMOCYSTEINA
SE)		5wrg SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 5
LEU A 636
GLN A 630
THR A 678
HIS A 641
1.69A17.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_1
(ADENOSINE KINASE)		5x4r S PROTEIN
(MERS-CoV)		5 / 12
GLY A  90
PHE A  40
GLN A  36
GLN A  37
ASP A  34
1.60A19.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_1
(ADENOSINE KINASE)		5x4r S PROTEIN
(MERS-CoV)		5 / 12
GLY A  90
PHE A  40
GLN A  36
GLN A  37
ASP A  34
1.60A19.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_A_2FAA306_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		5x4s SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 10
SER A  35
GLY A 255
VAL A 254
GLU A 184
SER A  64
1.53A22.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_C_2FAC308_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		5x4s SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 11
SER A  35
GLY A 255
VAL A 254
GLU A 184
SER A  64
1.55A22.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		5x58 SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 12
ASP C 719
GLY B 579
GLY B 580
THR C 841
ASN C 746
1.38A15.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_A_2FAA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		5x59 S PROTEIN
(MERS-CoV)		5 / 11
ARG C 614
SER C 656
GLY A 931
ASP A 805
VAL A 804
1.73A10.73
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_B_2FAB301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		5x59 S PROTEIN
(MERS-CoV)		5 / 12
ARG C 614
SER C 656
GLY A 931
ASP A 805
VAL A 804
1.75A10.73
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_B_2FAB301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 12
VAL A 763
GLU A 762
GLU A 755
SER A1003
VAL A1042
1.70A13.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_1
(ADENOSINE KINASE)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 12
GLY B 580
GLY B 579
MET C 722
GLN C 835
GLY B 634
1.56A13.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_1
(ADENOSINE KINASE)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 12
SER B 561
GLY B 552
PHE C  47
PHE B 545
ASP B 554
1.46A13.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_2
(ADENOSINE KINASE)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		4 / 4
ALA B 237
VAL B  98
PHE B 238
THR B  71
1.62A13.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_A_2FAA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 11
MET A 722
ARG A 982
VAL A 945
ASP C 554
VAL C 555
1.43A13.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_A_2FAA306_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 10
SER B  35
GLY B 255
VAL B 254
GLU B 184
SER B  64
1.64A11.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_C_2FAC308_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		5 / 11
SER B  35
GLY B 255
VAL B 254
GLU B 184
SER B  64
1.68A11.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_2
(ADENOSINE KINASE)		5x5b SPIKE GLYCOPROTEIN
(SARS-COV
BJ01)		4 / 4
ALA A 912
VAL A1047
GLY A1026
THR A 705
1.46A13.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_2
(ADENOSYLHOMOCYSTEINA
SE)		5x5c S PROTEIN
(MERS-CoV)		4 / 5
LEU A  74
GLN A  72
THR A 259
HIS A 264
1.69A16.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_1
(ADENOSINE KINASE)		5x5f S PROTEIN
(MERS-CoV)		5 / 12
GLY B  90
PHE B  40
GLN B  36
GLN B  37
ASP B  34
1.61A13.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_1
(ADENOSINE KINASE)		5x5f S PROTEIN
(MERS-CoV)		5 / 12
GLY B  90
PHE B  40
GLN B  36
GLN B  37
ASP B  34
1.61A13.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_1
(ADENOSINE KINASE)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
GLY B 781
GLY B 780
PHE B 779
PHE B 880
GLN B 883
1.59A14.42
GLY  B 781 ( 0.0A)
GLY  B 780 ( 0.0A)
PHE  B 779 ( 1.3A)
PHE  B 880 ( 1.3A)
GLN  B 883 ( 0.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_2
(ADENOSINE KINASE)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 5
LEU C 374
ILE C 345
ALA C 350
PHE C 325
1.48A15.70
LEU  C 374 ( 0.6A)
ILE  C 345 ( 0.7A)
ALA  C 350 ( 0.0A)
PHE  C 325 ( 1.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_2
(ADENOSINE KINASE)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 4
ALA A 858
VAL A 860
PHE A 870
THR A 865
1.64A14.42
ALA  A 858 ( 0.0A)
VAL  A 860 ( 0.6A)
PHE  A 870 ( 1.3A)
THR  A 865 ( 0.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_2
(ADENOSINE KINASE)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 4
ALA B 284
VAL B 594
GLY B 587
THR B 588
1.42A14.42
ALA  B 284 ( 0.0A)
VAL  B 594 ( 0.5A)
GLY  B 587 ( 0.0A)
THR  B 588 ( 0.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		5xlr SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
ASN C 838
ASP C 727
GLY C 726
ASN C 960
GLY A 534
1.39A15.70
ASN  C 838 ( 0.6A)
ASP  C 727 ( 0.5A)
GLY  C 726 ( 0.0A)
ASN  C 960 ( 0.6A)
GLY  A 534 ( 0.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		5y3q REPLICASE
POLYPROTEIN 1A
(SARSr-CoV)		5 / 12
ASN A 111
LEU A 119
GLY A 164
VAL A 166
GLY A 272
1.37A19.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_C_2FAC308_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		6acc SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 11
SER A  35
GLY A 255
VAL A 254
GLU A 184
SER A  64
1.61A12.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_D_2FAD500_1
(ADENOSYLHOMOCYSTEINA
SE)		6acd SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
THR C 678
LYS B 796
ASP B 850
GLY C 655
MET B 851
1.62A17.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_1
(ADENOSYLHOMOCYSTEINA
SE)		6acd SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
THR C 678
LYS B 796
ASP B 850
GLY C 655
MET B 851
1.64A17.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_2
(ADENOSINE KINASE)		6acd SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 5
LEU C 355
ILE C 345
ALA C 350
PHE C 325
1.42A15.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_1
(ADENOSYLHOMOCYSTEINA
SE)		6acd SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
THR B 678
LYS A 796
ASP A 850
GLY B 655
MET A 851
1.74A17.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_2
(ADENOSYLHOMOCYSTEINA
SE)		6acg SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 5
LEU C 286
GLN C 301
THR C 302
THR C 585
1.53A17.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_2
(ADENOSINE KINASE)		6acg SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 4
ALA B 658
VAL B 628
GLY B 634
THR B 631
1.40A14.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_B_2FAB301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		6acg SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
SER B 303
GLY B 580
VAL B 581
GLU B 285
ASP A 719
1.64A13.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_D_2FAD500_2
(ADENOSYLHOMOCYSTEINA
SE)		6acg SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 4
LEU C 286
GLN C 301
THR C 302
THR C 585
1.39A17.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_2
(ADENOSINE KINASE)		6acg ACE2
(Homo
sapiens)		4 / 5
LEU D 320
ILE D 407
ALA D 550
MET D 408
1.34A19.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		6acg SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
GLY C 580
GLY C 579
THR C 616
LEU C 615
ASN B 721
1.33A15.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_1
(ADENOSINE KINASE)		6acg SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
GLY A 490
GLY A 391
PHE A 483
ALA A 422
ASP A 393
1.36A14.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_1
(ADENOSINE KINASE)		6acj ACE2
(Homo
sapiens)		5 / 12
GLY D 399
ASN D 397
PHE D 525
ALA D 569
GLY D 395
1.39A19.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_A_2FAA306_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		6acj SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 10
SER C  35
GLY C 255
VAL C 254
GLU C 184
SER C  64
1.45A12.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_A_2FAA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		6acj SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 11
MET A 722
ARG A 982
VAL A 945
ASP B 554
VAL B 555
1.44A13.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_2
(ADENOSINE KINASE)		6acj SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 4
ALA A 237
VAL A  98
PHE A 238
THR A  71
1.61A14.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		6ack ACE2
(Homo
sapiens)		5 / 12
LEU D 520
GLY D 448
THR D 519
LEU D 584
GLY D 272
1.34A19.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_1
(ADENOSINE KINASE)		6ack SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
GLY C1017
ALA C1008
GLN C 766
GLY C 871
ASP A1023
1.51A14.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_2
(ADENOSINE KINASE)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 4
ALA B 639
VAL B 628
GLY B 634
THR B 631
1.32A12.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_1
(ADENOSINE KINASE)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
SER A 985
GLY A 981
PHE B 741
GLN B 984
GLN B 987
1.50A12.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_1
(ADENOSINE KINASE)		6crv SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
SER A 985
GLY A 981
PHE B 741
GLN B 984
GLN B 987
1.51A12.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_1
(ADENOSINE KINASE)		6crw SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
ASP A 727
GLY A 726
PHE C 578
GLN A 835
GLY C 534
1.28A12.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_1
(ADENOSINE KINASE)		6crw SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
SER A 985
GLY A 981
PHE B 741
GLN B 984
GLN B 987
1.47A12.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_2
(ADENOSYLHOMOCYSTEINA
SE)		6crw SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 5
LEU C 843
GLN C 835
THR C 841
THR B 631
1.53A17.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_D_2FAD500_2
(ADENOSYLHOMOCYSTEINA
SE)		6crw SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 4
LEU C 843
GLN C 835
THR C 841
THR B 631
1.65A17.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_2
(ADENOSINE KINASE)		6crx SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 4
ALA B 237
VAL B  98
PHE B 238
THR B  71
1.67A12.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_A_2FAA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		6crx SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 11
MET C 722
ARG C 982
VAL C 945
ASP B 554
VAL B 555
1.44A12.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_2
(ADENOSINE KINASE)		6crz SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 5
LEU A 132
ILE A 117
ALA A 156
PHE A 153
1.37A16.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		6crz SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 12
ASP A 719
GLY C 579
GLY C 580
THR A 841
ASN A 746
1.36A16.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_C_2FAC308_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		6cs1 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 11
ARG B1021
SER B1019
GLY B1017
VAL A1022
GLU B1013
1.74A12.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_1
(ADENOSINE KINASE)		6cs2 ACE2
SPIKE
GLYCOPROTEIN,FIBRITI
N
(Homo
sapiens;
SARSr-CoV)		5 / 12
GLY D 354
PHE D 356
ALA D 386
GLY B 490
ASP B 392
1.50A19.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_A_2FAA306_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		6cs2 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 10
SER B  35
GLY B 255
VAL B 254
GLU B 184
SER B  64
1.64A12.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_2
(ADENOSINE KINASE)		6cs2 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		4 / 4
ALA C 639
VAL C 628
GLY C 634
THR C 631
1.28A12.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_2
(ADENOSINE KINASE)		6cs2 ACE2
(Homo
sapiens)		4 / 5
LEU D 320
ILE D 407
ALA D 550
MET D 408
1.77A20.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z35_A_2FAA300_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		6cs2 SPIKE
GLYCOPROTEIN,FIBRITI
N
(SARSr-CoV)		5 / 10
THR C 760
GLY C1041
THR C 856
VAL C1042
SER C 712
1.75A12.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		5 / 12
ASN A 114
GLY A 100
THR C   3
LEU A 156
GLY A  26
1.38A21.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_2
(ADENOSYLHOMOCYSTEINA
SE)		6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 5
LEU A  78
GLN A  96
THR A  94
THR A  73
1.60A21.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_1
(ADENOSINE KINASE)		6jyt HELICASE
(SARSr-CoV)		5 / 12
GLY B 282
MET B 429
ALA B 403
GLN B 404
GLY B 285
1.34A20.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z35_A_2FAA300_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		6jyt HELICASE
(SARSr-CoV)		5 / 10
THR A 550
GLY A 478
THR A 481
VAL A 479
SER A 577
1.79A19.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		6lxt SPIKE PROTEIN S2
(SARS-CoV-2)		5 / 12
LEU E1186
GLY D 946
THR E 941
LEU E 945
ASN D1187
1.20A15.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_2
(ADENOSINE KINASE)		6lze VIRAL PROTEASE
(SARS-CoV-2)		4 / 4
ALA A 206
VAL A 261
GLY A 258
THR A 257
1.76A23.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_2
(ADENOSYLHOMOCYSTEINA
SE)		6lze VIRAL PROTEASE
(SARS-CoV-2)		4 / 5
GLN A 110
THR A 111
THR A 201
LEU A 250
1.39A20.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		6lze VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
ASP A 216
GLY A 283
LEU A 287
ASN A 214
GLY A   2
1.66A19.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_1
(ADENOSYLHOMOCYSTEINA
SE)		6lze VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
HIS A  41
LEU A  27
GLY A 146
HIS A 163
PHE A 181
1.79A20.00
ALC  D   2 ( 4.1A)
None
None
ELL  D   3 (-3.9A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		6lze VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
LEU A 205
VAL A 296
LEU A 250
ASN A 214
GLY A 215
1.64A19.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_2
(ADENOSINE KINASE)		6lzg ACE2
(Homo
sapiens)		4 / 5
LEU A 320
ILE A 407
ALA A 550
MET A 408
1.56A20.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_1
(ADENOSINE KINASE)		6m0j ACE2
SPIKE RECEPTOR
BINDING DOMAIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
GLY E 502
GLY A 354
PHE A 356
ALA A 387
ASP E 405
1.72A21.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_2
(ADENOSINE KINASE)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		4 / 4
ALA A 206
VAL A 261
GLY A 258
THR A 257
1.76A23.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
LEU A 205
VAL A 296
LEU A 250
ASN A 214
GLY A 215
1.64A19.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_2
(ADENOSYLHOMOCYSTEINA
SE)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		4 / 5
GLN A 110
THR A 111
THR A 201
LEU A 250
1.53A19.96
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_1
(ADENOSYLHOMOCYSTEINA
SE)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
HIS A  41
LEU A  27
GLY A 146
HIS A 163
PHE A 181
1.80A19.96
N0A  D   2 ( 4.0A)
None
None
ELL  D   3 (-3.9A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		6m0k VIRAL PROTEASE
(SARS-CoV-2)		5 / 12
ASP A 216
GLY A 283
LEU A 287
ASN A 214
GLY A   2
1.67A19.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_B_2FAB301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		6m17 SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 12
ARG A  97
SER A 291
GLY A  99
GLU A  28
SER A 288
1.60A15.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_1
(ADENOSINE KINASE)		6m17 SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 12
SER C 491
ASP C 486
GLY C 490
ALA C 273
GLN C 274
1.62A18.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_B_2FAB307_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		6m17 SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 9
ARG A  97
SER A 291
GLY A  99
GLU A  28
SER A 288
1.63A17.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_A_2FAA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		6m17 SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 11
ARG A  97
SER A 291
GLY A  99
GLU A  28
SER A 288
1.57A15.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		6m18 SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 12
LEU A  88
GLY A 285
GLY A 284
LEU A  85
GLY A  99
1.18A20.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_C_2FAC308_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		6m18 SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 11
SER A 430
GLY A 428
MET A 423
SER A 431
ILE A 132
1.43A17.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		6m1d ACE2
(Homo
sapiens)		5 / 12
LEU B 529
GLY B 399
ASN B 397
VAL B 404
GLY B 395
1.25A18.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_2
(ADENOSINE KINASE)		6m1d SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		4 / 5
LEU C  85
ALA C 282
MET C 542
PHE C 276
1.45A20.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_B_2FAB301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		6m1d ACE2
(Homo
sapiens)		5 / 12
ARG B 482
VAL B 491
GLU B 489
ASP B 494
VAL B 691
1.75A15.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_1
(ADENOSYLHOMOCYSTEINA
SE)		6m1d SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 12
LEU A  21
LYS A 516
ASP A 517
GLY A  93
PHE A 520
1.55A22.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_2
(ADENOSINE KINASE)		6m1d ACE2
(Homo
sapiens)		4 / 5
ILE D 358
ALA D 372
MET D 360
PHE D 308
1.22A18.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_1
(ADENOSINE KINASE)		6m1d SODIUM-DEPENDENT
NEUTRAL AMINO ACID
TRANSPORTER B(0)AT1
(Homo
sapiens)		5 / 12
SER A 106
ASP A 445
GLY A  99
GLY A 102
GLY A 115
1.54A18.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_A_2FAA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		6m1d ACE2
(Homo
sapiens)		5 / 11
ARG B 482
VAL B 491
GLU B 489
ASP B 494
VAL B 691
1.73A15.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
GLY A   2
ASN A 214
VAL C 171
GLY A 215
ASP A 216
1.63A19.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
GLY D   2
GLY B 138
THR B 169
LEU B 167
GLY D 283
1.64A19.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_2
(ADENOSYLHOMOCYSTEINA
SE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 5
GLN C 110
THR C 111
THR C 201
LEU C 250
1.24A19.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_1
(ADENOSYLHOMOCYSTEINA
SE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
HIS C  41
LEU C  27
GLY C 146
HIS C 163
PHE C 181
1.78A19.88
3WL  C 401 (-3.4A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
LEU B 205
VAL B 296
LEU B 250
ASN B 214
GLY B 215
1.57A19.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_2
(ADENOSYLHOMOCYSTEINA
SE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 5
GLN A 110
THR A 111
THR A 201
LEU A 250
1.33A19.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
LEU A 205
VAL A 296
LEU A 250
ASN A 214
GLY A 215
1.58A19.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_2
(ADENOSINE KINASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 4
ALA D 206
VAL D 261
GLY D 258
THR D 257
1.75A23.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
LEU C 205
VAL C 296
LEU C 250
ASN C 214
GLY C 215
1.63A19.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_2
(ADENOSYLHOMOCYSTEINA
SE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 5
GLN D 110
THR D 111
THR D 201
LEU D 250
1.30A19.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
GLY C   2
GLY A 138
THR A 169
LEU A 167
GLY C 283
1.62A19.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_1
(ADENOSYLHOMOCYSTEINA
SE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
HIS D  41
LEU D  27
GLY D 146
HIS D 163
PHE D 181
1.80A19.88
3WL  D 401 (-3.9A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_2
(ADENOSYLHOMOCYSTEINA
SE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 5
GLN B 110
THR B 111
THR B 201
LEU B 250
1.31A19.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_2
(ADENOSINE KINASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 4
ALA C 206
VAL C 261
GLY C 258
THR C 257
1.67A23.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		5 / 12
LEU D  32
GLY D 174
VAL D  86
LEU D  30
ASN D 180
1.67A19.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_2
(ADENOSINE KINASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 4
ALA B 206
VAL B 261
GLY B 258
THR B 257
1.74A23.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_2
(ADENOSINE KINASE)		6m2n 3CL PROTEASE
(SARS-CoV-2)		4 / 4
ALA A 206
VAL A 261
GLY A 258
THR A 257
1.75A23.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		6m2q 3CL PROTEASE
(SARS-CoV-2)		5 / 12
LEU A 205
VAL A 296
LEU A 250
ASN A 214
GLY A 215
1.65A19.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		6m2q 3CL PROTEASE
(SARS-CoV-2)		5 / 12
ASP A 216
GLY A 283
LEU A 287
ASN A 214
GLY A   2
1.66A19.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_2
(ADENOSINE KINASE)		6m2q 3CL PROTEASE
(SARS-CoV-2)		4 / 4
ALA A 206
VAL A 261
GLY A 258
THR A 257
1.76A23.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_2
(ADENOSYLHOMOCYSTEINA
SE)		6m2q 3CL PROTEASE
(SARS-CoV-2)		4 / 5
GLN A 110
THR A 111
THR A 201
LEU A 250
1.22A19.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_2
(ADENOSYLHOMOCYSTEINA
SE)		6m3m NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 5
LEU B 168
GLN B 161
THR B  58
HIS B  60
1.60A16.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_A_2FAA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		6m71 NSP12
(SARS-CoV-2)		5 / 11
MET A 666
SER A 343
GLY A 345
VAL A 535
VAL A 354
1.57A13.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_1
(ADENOSINE KINASE)		6m71 NSP12
(SARS-CoV-2)		5 / 12
GLY A 671
GLY A 670
PHE A 407
ALA A 449
ASP A 390
1.79A16.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		6m71 NSP12
(SARS-CoV-2)		5 / 12
GLY A 352
ASN A 314
VAL A 354
LEU A 329
ASN A 300
1.63A17.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		6m71 NSP12
(SARS-CoV-2)		5 / 12
LEU A 727
GLY A 712
ASN A 713
LEU A 707
ASN A  39
1.67A17.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		6m71 NSP12
NSP8
(SARS-CoV-2)		5 / 12
LEU A 366
VAL A 373
LEU B  91
ASN A 356
GLY A 345
1.66A17.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_2
(ADENOSINE KINASE)		6m71 NSP12
(SARS-CoV-2)		4 / 5
LEU A 514
ALA A 502
MET A 519
PHE A 506
1.51A17.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_2
(ADENOSINE KINASE)		6m71 NSP7
(SARS-CoV-2)		4 / 4
ALA C  48
VAL C  53
PHE C  49
THR C   9
1.65A11.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_2
(ADENOSYLHOMOCYSTEINA
SE)		6m71 NSP12
(SARS-CoV-2)		4 / 5
GLN A 210
THR A 123
THR A 148
LEU A 178
1.77A20.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_2
(ADENOSINE KINASE)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 4
ALA B 284
VAL B 594
GLY B 587
THR B 588
1.56A13.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_D_2FAD500_2
(ADENOSYLHOMOCYSTEINA
SE)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 4
LEU B 843
GLN B 835
THR B 841
THR C 631
1.79A17.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z35_A_2FAA300_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 10
THR C 760
GLY C1041
THR C 856
VAL C1042
SER C 712
1.78A10.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_2
(ADENOSINE KINASE)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 5
LEU A 374
ILE A 345
ALA A 350
PHE A 325
1.45A15.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_1
(ADENOSINE KINASE)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		5 / 12
GLY C 781
GLY C 780
PHE C 779
PHE C 880
GLN C 883
1.54A13.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_2
(ADENOSYLHOMOCYSTEINA
SE)		6nb6 SPIKE GLYCOPROTEIN
(SARSr-CoV)		4 / 5
LEU B 843
GLN B 835
THR B 841
THR C 631
1.67A17.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_2
(ADENOSYLHOMOCYSTEINA
SE)		6nb8 S230 ANTIGEN-BINDING
(FAB) FRAGMENT,
LIGHT CHAIN
(Homo
sapiens)		4 / 5
LEU L  29
GLN L  55
THR L  36
THR L 102
1.23A18.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_1
(ADENOSYLHOMOCYSTEINA
SE)		6nb8 S230 ANTIGEN-BINDING
(FAB) FRAGMENT,
HEAVY CHAIN
S230 ANTIGEN-BINDING
(FAB) FRAGMENT,
LIGHT CHAIN
(Homo
sapiens)		5 / 12
HIS L  98
ASP L  33
LEU L  29
GLY L  96
HIS H 112
1.73A18.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_2
(ADENOSINE KINASE)		6nb8 S230 ANTIGEN-BINDING
(FAB) FRAGMENT,
HEAVY CHAIN
(Homo
sapiens)		4 / 4
ALA H  61
VAL H  37
GLY H  44
THR H  43
1.28A21.96
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_D_2FAD500_2
(ADENOSYLHOMOCYSTEINA
SE)		6nb8 S230 ANTIGEN-BINDING
(FAB) FRAGMENT,
LIGHT CHAIN
(Homo
sapiens)		4 / 4
LEU L  29
GLN L  55
THR L  36
THR L 102
1.27A18.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		6nb8 S230 ANTIGEN-BINDING
(FAB) FRAGMENT,
HEAVY CHAIN
S230 ANTIGEN-BINDING
(FAB) FRAGMENT,
LIGHT CHAIN
(Homo
sapiens)		5 / 12
LEU H 192
GLY H 176
VAL H 195
ASN L 142
ASP L 172
1.42A16.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_2
(ADENOSINE KINASE)		6nur NSP7
(SARSr-CoV)		4 / 4
ALA C  48
VAL C  53
PHE C  49
THR C   9
1.67A11.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_2
(ADENOSINE KINASE)		6nus NSP12
(SARSr-CoV)		4 / 5
LEU A 514
ALA A 502
MET A 519
PHE A 506
1.57A16.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_B_2FAB301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		6nus NSP12
(SARSr-CoV)		5 / 12
ARG A 392
SER A 672
VAL A 667
MET A 542
VAL A 675
1.50A14.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_A_2FAA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		6nus NSP12
(SARSr-CoV)		5 / 11
MET A 666
SER A 343
GLY A 345
VAL A 535
VAL A 354
1.30A14.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_A_2FAA306_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 10
ARG B1019
GLY B 769
VAL B 772
GLU B 773
GLU A1017
1.79A12.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_2
(ADENOSYLHOMOCYSTEINA
SE)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 5
LEU B 962
GLN B 957
THR B 961
THR B 734
1.56A17.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_C_2FAC308_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 11
ARG B1019
GLY B 769
VAL B 772
GLU B 773
GLU A1017
1.74A12.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_2
(ADENOSINE KINASE)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 4
ALA A 647
VAL A 615
GLY A 593
THR B 859
1.49A15.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_2
(ADENOSINE KINASE)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 5
LEU C 611
ILE C 670
ALA C 653
PHE C 643
1.34A14.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		6 / 12
GLY C 593
GLY C 594
ASN C 317
LEU C 611
GLY A 857
ASP A 737
1.74A14.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_D_2FAD500_2
(ADENOSYLHOMOCYSTEINA
SE)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 4
LEU B 962
GLN B 957
THR B 961
THR B 734
1.65A17.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_1
(ADENOSINE KINASE)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
GLY A 799
GLY A 798
PHE A 797
PHE A 898
GLN A 901
1.59A15.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_A_2FAA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 11
ARG C1019
GLY C 769
VAL C 772
GLU C 773
GLU B1017
1.77A12.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_B_2FAB301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
HIS A1064
ARG C1039
SER A1037
GLY A1035
GLU A1031
1.79A12.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_1
(ADENOSINE KINASE)		6vsb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
GLY C 593
GLY C 594
ASN C 317
GLY A 857
ASP A 737
1.32A15.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_2
(ADENOSYLHOMOCYSTEINA
SE)		6vw1 ACE2
(Homo
sapiens)		4 / 5
LEU A 370
THR A 371
THR A 414
HIS A 417
1.60A20.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_1
(ADENOSINE KINASE)		6vw1 ACE2
SPIKE GLYCOPROTEIN
(Homo
sapiens;
SARS-CoV-2)		5 / 12
GLY F 502
GLY B 354
PHE B 356
ALA B 386
ASP F 405
1.44A17.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		6vxs NSP3
(SARS-CoV-2)		5 / 12
ASN B  37
LEU B  75
GLY B  47
LEU B  43
GLY B 130
1.70A
None
SO4  B 201 ( 4.4A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		6vxs NSP3
(SARS-CoV-2)		5 / 12
ASN A  37
LEU A  75
GLY A  47
LEU A  43
GLY A 130
1.64A
None
SO4  A 201 (-4.1A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		6vxs NSP3
(SARS-CoV-2)		5 / 12
ASN A  37
LEU A  75
GLY A  48
LEU A  43
GLY A 130
1.71A
None
SO4  A 201 (-4.1A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_A_2FAA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 11
ARG B1019
GLY B 769
VAL B 772
GLU B 773
GLU A1017
1.76A11.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_1
(ADENOSINE KINASE)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
GLY B 799
GLY B 798
PHE B 797
PHE B 898
GLN B 901
1.71A15.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_C_2FAC308_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 11
SER C  31
GLY C 268
VAL C 267
GLU C 191
SER C  60
1.53A12.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_A_2FAA306_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 10
SER C  31
GLY C 268
VAL C 267
GLU C 191
SER C  60
1.52A12.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_2
(ADENOSINE KINASE)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 4
ALA A 930
VAL A1065
GLY A1044
THR A 723
1.54A15.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z35_A_2FAA300_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 10
THR B 719
GLY B1046
THR C 887
GLU B1072
SER B 721
1.77A11.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_2
(ADENOSINE KINASE)		6vxx SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 5
LEU B 878
ALA B 876
MET B1029
PHE B 888
1.58A15.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
GLY A 593
GLY A 594
ASN A 317
GLY B 857
ASP B 737
1.28A15.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_C_2FAC308_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 11
SER A  31
GLY A 268
VAL A 267
GLU A 191
SER A  60
1.43A12.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z35_A_2FAA300_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 10
ARG A1019
GLY A 769
VAL A 772
GLU A 773
GLU C1017
1.67A11.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_A_2FAA306_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 10
SER A  31
GLY A 268
VAL A 267
GLU A 191
SER A  60
1.43A12.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_A_2FAA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 11
SER A  31
GLY A 268
VAL A 267
GLU A 191
SER A  60
1.57A11.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_2
(ADENOSINE KINASE)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 5
LEU B 878
ALA B 876
MET B1029
PHE B 888
1.52A15.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_B_2FAB301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
SER A  31
GLY A 268
VAL A 267
GLU A 191
SER A  60
1.65A11.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_1
(ADENOSINE KINASE)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
GLY A 799
GLY A 798
PHE A 797
PHE A 898
GLN A 901
1.68A15.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_1
(ADENOSINE KINASE)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		5 / 12
GLY A 593
GLY A 594
ASN A 317
GLY B 857
ASP B 737
1.34A15.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_2
(ADENOSINE KINASE)		6vyb SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 4
ALA B 930
VAL B1065
GLY B1044
THR B 723
1.42A15.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_1
(ADENOSINE KINASE)		6vyo NUCLEOPROTEIN
(SARS-CoV-2)		5 / 12
ASP C  98
GLY C  99
GLY C  97
ALA D 119
ASP D 144
1.40A17.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_1
(ADENOSINE KINASE)		6vyo NUCLEOPROTEIN
(SARS-CoV-2)		5 / 12
ASP C  98
GLY C  99
GLY C  97
ALA D 119
ASP D 144
1.41A17.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_2
(ADENOSYLHOMOCYSTEINA
SE)		6vyo NUCLEOPROTEIN
(SARS-CoV-2)		4 / 5
LEU D 167
GLN D 160
THR D  57
HIS D  59
1.49A13.93
None
None
None
ZN  A 204 ( 3.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_D_2FAD500_1
(ADENOSYLHOMOCYSTEINA
SE)		6vyo NUCLEOPROTEIN
(SARS-CoV-2)		5 / 12
THR D 115
ASP D  82
HIS C  59
GLY D 147
PHE D 110
1.77A13.93
None
ZN  D 201 ( 2.4A)
ZN  D 201 ( 3.3A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		5 / 12
LEU H 178
GLY H 162
VAL H 181
ASN L 137
ASP L 167
1.48A19.40
GOL  L 301 (-4.9A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_2
(ADENOSYLHOMOCYSTEINA
SE)		6w41 CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 5
GLN L 100
THR L 102
THR L  72
LEU L  33
1.71A16.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		5 / 12
ASP H 144
LEU L 179
THR L 180
LEU L 181
GLY H 174
1.77A19.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_2
(ADENOSINE KINASE)		6w41 SPIKE PROTEIN S1
(SARS-CoV-2)		4 / 5
LEU C 387
ILE C 358
ALA C 363
PHE C 338
1.60A17.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		6w41 CR3022 FAB HEAVY
CHAIN
CR3022 FAB LIGHT
CHAIN
(Homo
sapiens)		5 / 12
LEU H 178
GLY H 162
VAL H 181
ASN L 138
ASP L 167
1.56A19.40
GOL  L 301 (-4.9A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_2
(ADENOSYLHOMOCYSTEINA
SE)		6w4h NSP10
(SARS-CoV-2)		4 / 5
GLN B4306
THR B4309
THR B4300
HIS B4301
1.62A13.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_2
(ADENOSYLHOMOCYSTEINA
SE)		6w4h NSP16
(SARS-CoV-2)		4 / 5
LEU A6887
THR A6891
THR A6880
HIS A6867
1.62A20.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_2
(ADENOSINE KINASE)		6w4h NSP10
NSP16
(SARS-CoV-2)		4 / 4
ALA B4324
VAL A6876
GLY A6879
THR A6880
1.22A18.44
None
None
SAM  A7102 (-3.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_1
(ADENOSINE KINASE)		6w4h NSP16
(SARS-CoV-2)		5 / 12
SER A6964
GLY A6962
GLY A6963
ASN A7008
GLY A7076
1.64A20.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_2
(ADENOSINE KINASE)		6w61 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		4 / 4
ALA B4324
VAL A6876
GLY A6879
THR A6880
1.22A
None
None
SAM  A7104 (-3.6A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_2
(ADENOSYLHOMOCYSTEINA
SE)		6w61 NSP10
(SARS-CoV-2)		4 / 5
GLN B4306
THR B4309
THR B4300
HIS B4301
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_C_2FAC500_2
(ADENOSYLHOMOCYSTEINA
SE)		6w61 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		4 / 5
LEU B4298
GLN A6850
THR A6846
HIS B4301
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_C_2FAC500_2
(ADENOSYLHOMOCYSTEINA
SE)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 5
LEU A6887
THR A6891
THR A6880
HIS A6867
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_2
(ADENOSYLHOMOCYSTEINA
SE)		6w61 NSP10
(SARS-CoV-2)		4 / 5
GLN B4306
THR B4309
THR B4300
HIS B4301
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
LEU A6887
GLY A6962
GLY A6963
ASN A7008
GLY A7076
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_1
(ADENOSINE KINASE)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
SER A6964
GLY A6962
GLY A6963
ASN A7008
GLY A7076
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_2
(ADENOSYLHOMOCYSTEINA
SE)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 5
LEU A6887
THR A6891
THR A6880
HIS A6867
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
LEU A6887
ASN A6920
THR A6891
LEU A6893
ASN A7083
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_2
(ADENOSYLHOMOCYSTEINA
SE)		6w61 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 5
GLN A6847
THR A6993
HIS A6867
LEU A6883
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_C_2FAC500_1
(ADENOSYLHOMOCYSTEINA
SE)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
HIS A  41
LEU A  27
GLY A 146
HIS A 163
PHE A 181
1.78A19.88
X77  A 401 (-3.2A)
X77  A 401 ( 3.9A)
None
X77  A 401 (-4.1A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_1
(ADENOSYLHOMOCYSTEINA
SE)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
HIS A  41
LEU A  27
GLY A 146
HIS A 163
PHE A 181
1.67A19.88
X77  A 401 (-3.2A)
X77  A 401 ( 3.9A)
None
X77  A 401 (-4.1A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_2
(ADENOSYLHOMOCYSTEINA
SE)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 5
GLN A 110
THR A 111
THR A 201
LEU A 250
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_2
(ADENOSINE KINASE)		6w63 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 4
ALA A 206
VAL A 261
GLY A 258
THR A 257
1.76A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		6w6y NSP3
(SARS-CoV-2)		5 / 12
LEU A 164
GLY A 133
ASN A  99
LEU A 160
GLY A  97
1.79A19.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		6w6y NSP3
(SARS-CoV-2)		5 / 12
ASN A  37
LEU A  75
GLY A  47
LEU A  43
GLY A 130
1.70A
None
None
None
None
AMP  A 201 ( 3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_C_2FAC500_2
(ADENOSYLHOMOCYSTEINA
SE)		6w75 NSP10
NSP16
(SARS-CoV-2)		4 / 5
LEU B4298
GLN A6850
THR A6846
HIS B4301
1.68A13.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_2
(ADENOSYLHOMOCYSTEINA
SE)		6w75 NSP10
(SARS-CoV-2)		4 / 5
GLN B4306
THR B4309
THR B4300
HIS B4301
1.60A13.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		6w75 NSP16
(SARS-CoV-2)		5 / 12
LEU C6887
GLY C6962
GLY C6963
ASN C7008
GLY C7076
1.62A19.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_2
(ADENOSYLHOMOCYSTEINA
SE)		6w75 NSP10
NSP16
(SARS-CoV-2)		4 / 5
LEU B4298
GLN A6850
THR A6846
HIS B4301
1.73A13.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_1
(ADENOSINE KINASE)		6w75 NSP16
(SARS-CoV-2)		5 / 12
SER A6964
GLY A6962
GLY A6963
ASN A7008
GLY A7076
1.66A16.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		6w75 NSP16
(SARS-CoV-2)		5 / 12
LEU A6855
GLY A6963
THR A6856
LEU A6857
GLY A7011
1.75A19.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_2
(ADENOSYLHOMOCYSTEINA
SE)		6w75 NSP10
(SARS-CoV-2)		4 / 5
GLN D4306
THR D4309
THR D4300
HIS D4301
1.63A13.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_2
(ADENOSINE KINASE)		6w75 NSP10
NSP16
(SARS-CoV-2)		4 / 4
ALA D4324
VAL C6876
GLY C6879
THR C6880
1.21A18.44
None
None
SAM  C7105 ( 3.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_2
(ADENOSYLHOMOCYSTEINA
SE)		6w75 NSP10
(SARS-CoV-2)		4 / 5
GLN D4306
THR D4309
THR D4300
HIS D4301
1.57A13.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_C_2FAC500_2
(ADENOSYLHOMOCYSTEINA
SE)		6w75 NSP10
NSP16
(SARS-CoV-2)		4 / 5
LEU D4298
GLN C6850
THR C6846
HIS D4301
1.66A13.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_2
(ADENOSYLHOMOCYSTEINA
SE)		6w75 NSP16
(SARS-CoV-2)		4 / 5
LEU A6887
THR A6891
THR A6880
HIS A6867
1.67A15.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_2
(ADENOSYLHOMOCYSTEINA
SE)		6w75 NSP16
(SARS-CoV-2)		4 / 5
GLN A6847
THR A6993
HIS A6867
LEU A6883
1.52A15.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_2
(ADENOSINE KINASE)		6w75 NSP10
NSP16
(SARS-CoV-2)		4 / 4
ALA B4324
VAL A6876
GLY A6879
THR A6880
1.20A18.44
None
None
SAM  A7102 ( 3.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_2
(ADENOSYLHOMOCYSTEINA
SE)		6w75 NSP10
(SARS-CoV-2)		4 / 5
GLN B4306
THR B4309
THR B4300
HIS B4301
1.53A13.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		6w75 NSP16
(SARS-CoV-2)		5 / 12
LEU C6909
ASN C6862
VAL A7094
ASN A7096
GLY C6890
1.65A19.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_1
(ADENOSINE KINASE)		6w75 NSP16
(SARS-CoV-2)		5 / 12
SER C6964
GLY C6962
GLY C6963
ASN C7008
GLY C7076
1.64A16.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_C_2FAC500_2
(ADENOSYLHOMOCYSTEINA
SE)		6w75 NSP10
(SARS-CoV-2)		4 / 5
GLN B4306
THR B4309
THR B4300
HIS B4301
1.57A13.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		6w75 NSP16
(SARS-CoV-2)		5 / 12
LEU A6887
GLY A6962
GLY A6963
ASN A7008
GLY A7076
1.65A19.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_2
(ADENOSYLHOMOCYSTEINA
SE)		6w75 NSP16
(SARS-CoV-2)		4 / 5
LEU C6887
THR C6891
THR C6880
HIS C6867
1.62A15.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_2
(ADENOSYLHOMOCYSTEINA
SE)		6w75 NSP16
(SARS-CoV-2)		4 / 5
GLN C6847
THR C6993
HIS C6867
LEU C6883
1.51A15.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_C_2FAC500_2
(ADENOSYLHOMOCYSTEINA
SE)		6w75 NSP16
(SARS-CoV-2)		4 / 5
LEU C6887
THR C6891
THR C6880
HIS C6867
1.63A15.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_C_2FAC500_2
(ADENOSYLHOMOCYSTEINA
SE)		6w75 NSP16
(SARS-CoV-2)		4 / 5
LEU A6887
THR A6891
THR A6880
HIS A6867
1.68A15.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		6w75 NSP16
(SARS-CoV-2)		5 / 12
ASN C6920
ASN C6862
VAL A7094
ASN A7096
GLY C6890
1.73A19.14
FMT  C7106 ( 4.1A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
LEU C 118
GLY C 163
VAL C 165
THR C 115
GLY C 271
1.45A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		6 / 12
ASP A 164
LEU A 118
GLY A 163
VAL A 165
THR A 115
GLY A 271
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
ASN B 110
LEU B 118
GLY B 163
VAL B 165
THR B 115
1.53A
None
None
None
None
CL  B 502 ( 4.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
ASN A 110
LEU A 118
VAL A 165
THR A 115
GLY A 266
1.47A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
ASN C 110
LEU C 118
GLY C 163
VAL C 165
THR C 115
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
LEU B 118
GLY B 163
VAL B 165
THR B 115
GLY B 271
1.47A
None
None
None
CL  B 502 ( 4.9A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
ASN B 110
LEU B 118
VAL B 165
THR B 115
GLY B 266
1.55A
None
None
None
CL  B 502 ( 4.9A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		6w9c PAPAIN-LIKE
PROTEINASE
(SARS-CoV-2)		5 / 12
ASN A 110
LEU A 118
GLY A 163
VAL A 165
THR A 115
1.44A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_2
(ADENOSINE KINASE)		6wiq NSP8
(SARS-CoV-2)		4 / 5
LEU B 128
ILE B 132
ALA B 188
PHE B 147
1.66A16.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_2
(ADENOSYLHOMOCYSTEINA
SE)		6wiq NSP7
NSP8
(SARS-CoV-2)		4 / 5
GLN B  88
THR B  89
THR A   9
LEU A  56
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_A_2FAA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 11
GLY E 328
VAL E 324
GLU E 323
MET E 322
ASP F 341
1.45A20.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
ASN D 285
ASP D 288
LEU C 331
GLY D 287
GLY D 295
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_1
(ADENOSYLHOMOCYSTEINA
SE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
HIS E 300
GLU E 290
ASP E 288
LEU E 352
HIS E 356
1.50A14.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
ASN C 285
ASP C 288
LEU D 331
GLY C 287
GLY C 295
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_1
(ADENOSYLHOMOCYSTEINA
SE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
HIS A 300
GLU A 290
ASP A 288
LEU A 352
HIS A 356
1.59A14.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_D_2FAD500_1
(ADENOSYLHOMOCYSTEINA
SE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
HIS E 300
GLU E 290
ASP E 288
LEU E 352
HIS E 356
1.54A14.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_A_2FAA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 11
GLY B 328
VAL B 324
GLU B 323
MET B 322
ASP A 341
1.53A20.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
ASN B 285
ASP B 288
LEU A 331
GLY B 287
GLY B 295
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_A_2FAA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 11
GLY A 328
VAL A 324
GLU A 323
MET A 322
ASP B 341
1.28A20.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_1
(ADENOSYLHOMOCYSTEINA
SE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
HIS D 300
GLU D 290
ASP D 288
LEU D 352
HIS D 356
1.51A14.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_B_2FAB301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
GLY B 328
VAL B 324
GLU B 323
MET B 322
ASP A 341
1.56A20.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_C_2FAC500_1
(ADENOSYLHOMOCYSTEINA
SE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
HIS B 300
GLU B 290
ASP B 288
LEU B 352
HIS B 356
1.53A14.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_A_2FAA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 11
GLY D 328
VAL D 324
GLU D 323
MET D 322
ASP C 341
1.53A20.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_2
(ADENOSINE KINASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 5
LEU D 331
ALA C 308
MET C 317
PHE D 314
1.67A15.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_D_2FAD500_1
(ADENOSYLHOMOCYSTEINA
SE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
HIS A 300
GLU A 290
ASP A 288
LEU A 352
HIS A 356
1.60A14.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_A_2FAA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 11
GLY F 328
VAL F 324
GLU F 323
MET F 322
ASP E 341
1.51A20.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
ASN F 285
ASP F 288
LEU E 331
GLY F 287
GLY F 295
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_2
(ADENOSINE KINASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 5
LEU F 331
ALA E 308
MET E 317
PHE F 314
1.66A15.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
ASN E 285
ASP E 288
LEU F 331
GLY E 287
GLY E 295
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_1
(ADENOSYLHOMOCYSTEINA
SE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
HIS C 300
GLU C 290
ASP C 288
LEU C 352
HIS C 356
1.61A14.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_C_2FAC500_1
(ADENOSYLHOMOCYSTEINA
SE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
HIS E 300
GLU E 290
ASP E 288
LEU E 352
HIS E 356
1.49A14.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_B_2FAB301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
GLY F 328
VAL F 324
GLU F 323
MET F 322
ASP E 341
1.57A20.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_A_2FAA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 11
GLY C 328
VAL C 324
GLU C 323
MET C 322
ASP D 341
1.48A20.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_A_2FAA306_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 10
GLY C 328
VAL C 324
GLU C 323
MET C 322
ASP D 341
1.64A18.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_2
(ADENOSINE KINASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 5
LEU B 331
ALA A 308
MET A 317
PHE B 314
1.73A15.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_A_2FAA306_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 10
GLY E 328
VAL E 324
GLU E 323
MET E 322
ASP F 341
1.54A18.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_2
(ADENOSINE KINASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 5
LEU A 331
ALA B 308
MET B 317
PHE A 314
1.66A15.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_A_2FAA306_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 10
GLY A 328
VAL A 324
GLU A 323
MET A 322
ASP B 341
1.40A18.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_C_2FAC500_1
(ADENOSYLHOMOCYSTEINA
SE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
HIS D 300
GLU D 290
ASP D 288
LEU D 352
HIS D 356
1.49A14.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_B_2FAB301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
GLY C 328
VAL C 324
GLU C 323
MET C 322
ASP D 341
1.54A20.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_D_2FAD500_1
(ADENOSYLHOMOCYSTEINA
SE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
HIS D 300
GLU D 290
ASP D 288
LEU D 352
HIS D 356
1.53A14.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_D_2FAD500_1
(ADENOSYLHOMOCYSTEINA
SE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
HIS F 300
GLU F 290
ASP F 288
LEU F 352
HIS F 356
1.62A14.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_C_2FAC308_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 11
GLY E 328
VAL E 324
GLU E 323
MET E 322
ASP F 341
1.56A18.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_B_2FAB301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
GLY A 328
VAL A 324
GLU A 323
MET A 322
ASP B 341
1.33A20.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_2
(ADENOSINE KINASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 5
LEU C 331
ALA D 308
MET D 317
PHE C 314
1.70A15.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_1
(ADENOSYLHOMOCYSTEINA
SE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
HIS F 300
GLU F 290
ASP F 288
LEU F 352
HIS F 356
1.61A14.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_1
(ADENOSYLHOMOCYSTEINA
SE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
HIS D 300
GLU D 290
ASP D 288
LEU D 352
HIS D 356
1.50A14.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_B_2FAB301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
GLY E 328
VAL E 324
GLU E 323
MET E 322
ASP F 341
1.51A20.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_1
(ADENOSYLHOMOCYSTEINA
SE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
HIS C 300
GLU C 290
ASP C 288
LEU C 352
HIS C 356
1.64A14.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_1
(ADENOSYLHOMOCYSTEINA
SE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
HIS F 300
GLU F 290
ASP F 288
LEU F 352
HIS F 356
1.58A14.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_1
(ADENOSYLHOMOCYSTEINA
SE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
HIS A 300
GLU A 290
ASP A 288
LEU A 352
HIS A 356
1.56A14.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_C_2FAC500_1
(ADENOSYLHOMOCYSTEINA
SE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
HIS A 300
GLU A 290
ASP A 288
LEU A 352
HIS A 356
1.56A14.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_D_2FAD500_1
(ADENOSYLHOMOCYSTEINA
SE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
HIS B 300
GLU B 290
ASP B 288
LEU B 352
HIS B 356
1.54A14.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_B_2FAB301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
GLY D 328
VAL D 324
GLU D 323
MET D 322
ASP C 341
1.57A20.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_1
(ADENOSYLHOMOCYSTEINA
SE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
HIS B 300
GLU B 290
ASP B 288
LEU B 352
HIS B 356
1.53A14.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_1
(ADENOSYLHOMOCYSTEINA
SE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
HIS B 300
GLU B 290
ASP B 288
LEU B 352
HIS B 356
1.53A14.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_C_2FAC500_1
(ADENOSYLHOMOCYSTEINA
SE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
HIS F 300
GLU F 290
ASP F 288
LEU F 352
HIS F 356
1.57A14.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
ASN A 285
ASP A 288
LEU B 331
GLY A 287
GLY A 295
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_1
(ADENOSYLHOMOCYSTEINA
SE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
HIS E 300
GLU E 290
ASP E 288
LEU E 352
HIS E 356
1.52A14.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_C_2FAC500_1
(ADENOSYLHOMOCYSTEINA
SE)		6wji NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
HIS C 300
GLU C 290
ASP C 288
LEU C 352
HIS C 356
1.60A14.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_C_2FAC500_2
(ADENOSYLHOMOCYSTEINA
SE)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		4 / 5
LEU D4298
GLN C6850
THR C6846
HIS D4301
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_2
(ADENOSYLHOMOCYSTEINA
SE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 5
LEU C6887
THR C6891
THR C6880
HIS C6867
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
LEU C6909
ASN C6862
VAL A7094
ASN A7096
GLY C6890
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_2
(ADENOSYLHOMOCYSTEINA
SE)		6wjt NSP10
(SARS-CoV-2)		4 / 5
GLN B4306
THR B4309
THR B4300
HIS B4301
1.56A
None
None
None
FMT  B4403 (-4.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_2
(ADENOSYLHOMOCYSTEINA
SE)		6wjt NSP10
(SARS-CoV-2)		4 / 5
GLN B4306
THR B4309
THR B4300
HIS B4301
1.62A
None
None
None
FMT  B4403 (-4.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_2
(ADENOSYLHOMOCYSTEINA
SE)		6wjt NSP10
(SARS-CoV-2)		4 / 5
GLN D4306
THR D4309
THR D4300
HIS D4301
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_2
(ADENOSYLHOMOCYSTEINA
SE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 5
GLN C6847
THR C6993
HIS C6867
LEU C6883
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_1
(ADENOSINE KINASE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
SER C6964
GLY C6962
GLY C6963
ASN C7008
GLY C7076
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_1
(ADENOSINE KINASE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
SER A6964
GLY A6962
GLY A6963
ASN A7008
GLY A7076
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_2
(ADENOSYLHOMOCYSTEINA
SE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 5
LEU A6887
THR A6891
THR A6880
HIS A6867
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_C_2FAC500_2
(ADENOSYLHOMOCYSTEINA
SE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 5
LEU C6887
THR C6891
THR C6880
HIS C6867
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_B_2FAB301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
ARG B4331
SER A6872
GLY A6879
VAL A6842
VAL A6882
1.72A18.99
None
SAH  A7102 ( 4.6A)
SAH  A7102 (-3.5A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
LEU C6887
GLY C6962
GLY C6963
ASN C7008
GLY C7076
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_2
(ADENOSYLHOMOCYSTEINA
SE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 5
GLN A6847
THR A6993
HIS A6867
LEU A6883
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_2
(ADENOSYLHOMOCYSTEINA
SE)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		4 / 5
LEU B4298
GLN A6850
THR A6846
HIS B4301
1.72A
FMT  B4403 (-4.7A)
None
None
FMT  B4403 (-4.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_2
(ADENOSINE KINASE)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		4 / 4
ALA B4324
VAL A6876
GLY A6879
THR A6880
1.21A
None
None
SAH  A7102 (-3.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
LEU A6887
GLY A6962
GLY A6963
ASN A7008
GLY A7076
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_C_2FAC500_2
(ADENOSYLHOMOCYSTEINA
SE)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		4 / 5
LEU B4298
GLN A6850
THR A6846
HIS B4301
1.66A
FMT  B4403 (-4.7A)
None
None
FMT  B4403 (-4.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		6 / 12
LEU C6893
GLY C6871
GLY C6869
THR C6880
LEU C6883
GLY C6911
1.75A
None
SAH  C7102 (-4.4A)
SAH  C7102 (-3.8A)
None
None
FMT  C7107 ( 3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_2
(ADENOSINE KINASE)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		4 / 4
ALA D4324
VAL C6876
GLY C6879
THR C6880
1.22A
None
None
SAH  C7102 (-3.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_B_2FAB301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		6wjt 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		5 / 12
ARG D4331
SER C6872
GLY C6879
VAL C6842
VAL C6882
1.69A18.99
None
SAH  C7102 (-4.7A)
SAH  C7102 (-3.5A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
ASN C6920
ASN C6862
VAL A7094
ASN A7096
GLY C6890
1.62A
FMT  C7103 (-4.0A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_2
(ADENOSYLHOMOCYSTEINA
SE)		6wjt NSP10
(SARS-CoV-2)		4 / 5
GLN D4306
THR D4309
THR D4300
HIS D4301
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_C_2FAC500_2
(ADENOSYLHOMOCYSTEINA
SE)		6wjt 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 5
LEU A6887
THR A6891
THR A6880
HIS A6867
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_C_2FAC500_2
(ADENOSYLHOMOCYSTEINA
SE)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 5
LEU B 167
GLN B 160
THR B  57
HIS B  59
1.79A
None
None
ZN  C 201 ( 4.4A)
ZN  C 201 (-3.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_2
(ADENOSYLHOMOCYSTEINA
SE)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 5
LEU A 167
GLN A 160
THR A  57
HIS A  59
1.72A
None
None
MES  B 201 (-4.7A)
ZN  B 202 (-2.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_D_2FAD500_1
(ADENOSYLHOMOCYSTEINA
SE)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
THR B 115
ASP B  82
HIS A  59
GLY B 147
PHE B 110
1.72A13.88
None
ZN  B 202 (-2.3A)
ZN  B 202 (-2.6A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_2
(ADENOSYLHOMOCYSTEINA
SE)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 5
LEU D 167
GLN D 160
THR D  57
HIS D  59
1.72A
None
None
ZN  A 201 ( 4.4A)
ZN  A 201 (-4.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_C_2FAC500_2
(ADENOSYLHOMOCYSTEINA
SE)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 5
LEU C 167
GLN C 160
THR C  57
HIS C  59
1.73A
None
None
ZN  D 202 ( 4.7A)
ZN  D 202 (-3.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_D_2FAD500_1
(ADENOSYLHOMOCYSTEINA
SE)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
THR D 115
ASP D  82
HIS C  59
GLY D 147
PHE D 110
1.79A13.88
None
ZN  D 202 (-2.7A)
ZN  D 202 (-3.2A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_2
(ADENOSYLHOMOCYSTEINA
SE)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 5
LEU B 167
GLN B 160
THR B  57
HIS B  59
1.73A
None
None
ZN  C 201 ( 4.4A)
ZN  C 201 (-3.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_2
(ADENOSYLHOMOCYSTEINA
SE)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 5
LEU C 167
GLN C 160
THR C  57
HIS C  59
1.67A
None
None
ZN  D 202 ( 4.7A)
ZN  D 202 (-3.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_C_2FAC500_2
(ADENOSYLHOMOCYSTEINA
SE)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 5
LEU D 167
GLN D 160
THR D  57
HIS D  59
1.76A
None
None
ZN  A 201 ( 4.4A)
ZN  A 201 (-4.1A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_D_2FAD500_1
(ADENOSYLHOMOCYSTEINA
SE)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
THR C 115
ASP C  82
HIS B  59
GLY C 147
PHE C 110
1.79A13.88
None
ZN  C 201 (-2.4A)
ZN  C 201 (-3.3A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_C_2FAC500_2
(ADENOSYLHOMOCYSTEINA
SE)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		4 / 5
LEU A 167
GLN A 160
THR A  57
HIS A  59
1.76A
None
None
MES  B 201 (-4.7A)
ZN  B 202 (-2.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		6wkp NUCLEOCAPSID PROTEIN
(SARS-CoV-2)		5 / 12
LEU D 159
GLY A 147
THR D  54
ASN A  75
ASP A  82
1.68A
None
None
None
None
ZN  A 201 (-2.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		6wkq NSP16
(SARS-CoV-2)		5 / 12
LEU C6887
GLY C6962
GLY C6963
ASN C7008
GLY C7076
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_2
(ADENOSYLHOMOCYSTEINA
SE)		6wkq NSP10
(SARS-CoV-2)		4 / 5
GLN D4306
THR D4309
THR D4300
HIS D4301
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		6wkq NSP16
(SARS-CoV-2)		5 / 12
ASN C6920
ASN C6862
VAL A7094
ASN A7096
GLY C6890
1.68A
FMT  C7106 ( 4.1A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_1
(ADENOSINE KINASE)		6wkq NSP16
(SARS-CoV-2)		5 / 12
SER C6964
GLY C6962
GLY C6963
ASN C7008
GLY C7076
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_1
(ADENOSINE KINASE)		6wkq NSP16
(SARS-CoV-2)		5 / 12
SER A6964
GLY A6962
GLY A6963
ASN A7008
GLY A7076
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_C_2FAC500_2
(ADENOSYLHOMOCYSTEINA
SE)		6wkq NSP16
(SARS-CoV-2)		4 / 5
LEU C6887
THR C6891
THR C6880
HIS C6867
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_2
(ADENOSYLHOMOCYSTEINA
SE)		6wkq NSP16
(SARS-CoV-2)		4 / 5
LEU A6887
THR A6891
THR A6880
HIS A6867
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_2
(ADENOSYLHOMOCYSTEINA
SE)		6wkq NSP16
(SARS-CoV-2)		4 / 5
GLN A6847
THR A6993
HIS A6867
LEU A6883
1.52A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_2
(ADENOSYLHOMOCYSTEINA
SE)		6wkq NSP10
(SARS-CoV-2)		4 / 5
GLN D4306
THR D4309
THR D4300
HIS D4301
1.57A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_2
(ADENOSINE KINASE)		6wkq NSP10
NSP16
(SARS-CoV-2)		4 / 4
ALA D4324
VAL C6876
GLY C6879
THR C6880
1.22A
None
None
SFG  C7103 ( 3.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		6wkq NSP16
(SARS-CoV-2)		5 / 12
LEU C6909
ASN C6862
VAL A7094
ASN A7096
GLY C6890
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		6wkq NSP16
(SARS-CoV-2)		5 / 12
LEU A6887
GLY A6962
GLY A6963
ASN A7008
GLY A7076
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_2
(ADENOSINE KINASE)		6wkq NSP10
NSP16
(SARS-CoV-2)		4 / 4
ALA B4324
VAL A6876
GLY A6879
THR A6880
1.21A
None
None
SFG  A7103 ( 3.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_2
(ADENOSYLHOMOCYSTEINA
SE)		6wkq NSP16
(SARS-CoV-2)		4 / 5
GLN C6847
THR C6993
HIS C6867
LEU C6883
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_C_2FAC500_2
(ADENOSYLHOMOCYSTEINA
SE)		6wkq NSP10
NSP16
(SARS-CoV-2)		4 / 5
LEU D4298
GLN C6850
THR C6846
HIS D4301
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_C_2FAC500_2
(ADENOSYLHOMOCYSTEINA
SE)		6wkq NSP10
NSP16
(SARS-CoV-2)		4 / 5
LEU B4298
GLN A6850
THR A6846
HIS B4301
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_2
(ADENOSYLHOMOCYSTEINA
SE)		6wkq NSP10
(SARS-CoV-2)		4 / 5
GLN B4306
THR B4309
THR B4300
HIS B4301
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_2
(ADENOSYLHOMOCYSTEINA
SE)		6wkq NSP10
(SARS-CoV-2)		4 / 5
GLN B4306
THR B4309
THR B4300
HIS B4301
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_2
(ADENOSYLHOMOCYSTEINA
SE)		6wkq NSP16
(SARS-CoV-2)		4 / 5
LEU C6887
THR C6891
THR C6880
HIS C6867
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_C_2FAC500_2
(ADENOSYLHOMOCYSTEINA
SE)		6wkq NSP16
(SARS-CoV-2)		4 / 5
LEU A6887
THR A6891
THR A6880
HIS A6867
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_2
(ADENOSYLHOMOCYSTEINA
SE)		6wkq NSP10
NSP16
(SARS-CoV-2)		4 / 5
LEU B4298
GLN A6850
THR A6846
HIS B4301
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_1
(ADENOSINE KINASE)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
SER A 113
ASP A 153
PHE A 305
ALA A   7
ASP A 295
1.55A23.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_1
(ADENOSYLHOMOCYSTEINA
SE)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
HIS A  41
LEU A  27
GLY A 146
HIS A 163
PHE A 181
1.77A19.88
U5G  A 401 (-3.3A)
U5G  A 401 ( 4.0A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_2
(ADENOSYLHOMOCYSTEINA
SE)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 5
GLN A 110
THR A 111
THR A 201
LEU A 250
1.43A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
LEU A 205
VAL A 296
LEU A 250
ASN A 214
GLY A 215
1.55A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_2
(ADENOSINE KINASE)		6wnp 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 4
ALA A 206
VAL A 261
GLY A 258
THR A 257
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_1
(ADENOSINE KINASE)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
SER A6964
GLY A6962
GLY A6963
ASN A7008
GLY A7076
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_2
(ADENOSYLHOMOCYSTEINA
SE)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 5
LEU A6887
THR A6891
THR A6880
HIS A6867
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_2
(ADENOSYLHOMOCYSTEINA
SE)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 5
GLN A6847
THR A6993
HIS A6867
LEU A6883
1.51A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_C_2FAC500_2
(ADENOSYLHOMOCYSTEINA
SE)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		4 / 5
LEU A6887
THR A6891
THR A6880
HIS A6867
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		6wq3 2'-O-METHYLTRANSFERA
SE
(SARS-CoV-2)		5 / 12
LEU A6887
GLY A6962
GLY A6963
ASN A7008
GLY A7076
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_C_2FAC500_2
(ADENOSYLHOMOCYSTEINA
SE)		6wq3 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		4 / 5
LEU B4298
GLN A6850
THR A6846
HIS B4301
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_2
(ADENOSINE KINASE)		6wq3 2'-O-METHYLTRANSFERA
SE
NSP10
(SARS-CoV-2)		4 / 4
ALA B4324
VAL A6876
GLY A6879
THR A6880
1.22A
None
None
SAH  A7101 (-3.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_2
(ADENOSYLHOMOCYSTEINA
SE)		6wq3 NSP10
(SARS-CoV-2)		4 / 5
GLN B4306
THR B4309
THR B4300
HIS B4301
1.60A
SO4  B4404 (-4.3A)
SO4  B4404 (-3.8A)
SO4  B4403 (-3.2A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_2
(ADENOSYLHOMOCYSTEINA
SE)		6wq3 NSP10
(SARS-CoV-2)		4 / 5
GLN B4306
THR B4309
THR B4300
HIS B4301
1.54A
SO4  B4404 (-4.3A)
SO4  B4404 (-3.8A)
SO4  B4403 (-3.2A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_2
(ADENOSYLHOMOCYSTEINA
SE)		6wqd NSP7
NSP8
(SARS-CoV-2)		4 / 5
GLN D  88
THR D  89
THR C   9
LEU C  56
1.47A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		6wqd NSP7
NSP8
(SARS-CoV-2)		5 / 12
LEU A  13
GLY A  64
VAL A  66
LEU A  17
GLY B 113
1.38A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_2
(ADENOSINE KINASE)		6wqd NSP8
(SARS-CoV-2)		4 / 5
LEU D 128
ILE D 132
ALA D 188
PHE D 147
1.78A16.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		6wqd NSP7
NSP8
(SARS-CoV-2)		5 / 12
LEU C  13
GLY C  64
VAL C  66
LEU C  17
GLY D 113
1.26A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		6wqd NSP7
NSP8
(SARS-CoV-2)		5 / 12
LEU C  17
GLY C  64
VAL C  66
LEU C  20
GLY D 113
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_2
(ADENOSYLHOMOCYSTEINA
SE)		6wqd NSP7
NSP8
(SARS-CoV-2)		4 / 5
GLN B  88
THR B  89
THR A   9
LEU A  56
1.48A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
ASP A 216
GLY A 283
LEU A 287
ASN A 214
GLY A   2
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
LEU A 205
VAL A 296
LEU A 250
ASN A 214
GLY A 215
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_2
(ADENOSINE KINASE)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 4
ALA A 206
VAL A 261
GLY A 258
THR A 257
1.77A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_2
(ADENOSYLHOMOCYSTEINA
SE)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		4 / 5
GLN A 110
THR A 111
THR A 201
LEU A 250
1.20A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_1
(ADENOSYLHOMOCYSTEINA
SE)		6wqf 3C-LIKE PROTEINASE
(SARS-CoV-2)		5 / 12
HIS A  41
LEU A  27
GLY A 146
HIS A 163
PHE A 181
1.78A19.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_2
(ADENOSYLHOMOCYSTEINA
SE)		6y2e REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 5
GLN A 110
THR A 111
THR A 201
LEU A 250
1.20A19.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		6y2g REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU B 208
GLY B 275
ASN B 277
LEU B 268
GLY B 278
1.40A19.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_1
(ADENOSYLHOMOCYSTEINA
SE)		6y2g REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
HIS B  41
LEU B  27
GLY B 146
HIS B 163
PHE B 181
1.73A19.88
O6K  B 401 ( 3.7A)
None
None
O6K  B 401 ( 4.0A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_1
(ADENOSYLHOMOCYSTEINA
SE)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
HIS A  41
LEU A  27
GLY A 146
HIS A 163
PHE A 181
1.79A14.75
None
None
None
DMS  A 405 (-3.9A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_2
(ADENOSINE KINASE)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 4
ALA A 206
VAL A 261
GLY A 258
THR A 257
1.75A18.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU A 205
VAL A 296
LEU A 250
ASN A 214
GLY A 215
1.67A17.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_2
(ADENOSYLHOMOCYSTEINA
SE)		6yb7 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 5
GLN A 110
THR A 111
THR A 201
LEU A 250
1.51A14.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
LEU A  13
GLY A  64
VAL A  66
LEU A  17
GLY B 113
1.30A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
LEU C  17
GLY C  64
VAL C  66
LEU C  20
GLY D 113
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_2
(ADENOSINE KINASE)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 5
LEU D 128
ILE D 132
ALA D 188
PHE D 147
1.78A15.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_2
(ADENOSYLHOMOCYSTEINA
SE)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		4 / 5
GLN D  88
THR D  89
THR C   9
LEU C  56
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		6yhu REPLICASE
POLYPROTEIN 1A
(SARS-CoV-2)		5 / 12
LEU C  13
GLY C  64
VAL C  66
LEU C  17
GLY D 113
1.28A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_2
(ADENOSINE KINASE)		6yla SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 5
LEU A 387
ILE A 358
ALA A 363
PHE A 338
1.70A20.74
DMS  A 905 ( 4.2A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_1
(ADENOSINE KINASE)		6yla HEAVY CHAIN
(Homo
sapiens)		5 / 12
SER H 100
ASP H 107
GLY H  98
GLY H  99
GLN H   1
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_2
(ADENOSINE KINASE)		6ym0 HEAVY CHAIN
(Homo
sapiens)		4 / 4
ALA H  92
VAL H  37
GLY H 112
THR H 113
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_2
(ADENOSINE KINASE)		6ym0 HEAVY CHAIN
(Homo
sapiens)		4 / 4
ALA H  79
VAL H   5
GLY H 112
THR H 113
1.61A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_2
(ADENOSINE KINASE)		6ym0 SPIKE GLYCOPROTEIN
(SARS-CoV-2)		4 / 5
LEU E 387
ILE E 358
ALA E 363
PHE E 338
1.80A20.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_2
(ADENOSYLHOMOCYSTEINA
SE)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 5
GLN A 110
THR A 111
THR A 201
LEU A 250
1.17A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU A 205
VAL A 296
LEU A 250
ASN A 214
GLY A 215
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_1
(ADENOSYLHOMOCYSTEINA
SE)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
HIS A  41
LEU A  27
GLY A 146
HIS A 163
PHE A 181
1.79A19.88
None
None
None
P6N  A 502 (-3.8A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
ASP A 216
GLY A 283
LEU A 287
ASN A 214
GLY A   2
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_2
(ADENOSINE KINASE)		6ynq REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 4
ALA A 206
VAL A 261
GLY A 258
THR A 257
1.73A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_1
(ADENOSINE KINASE)		6yor IGG H CHAIN
(Homo
sapiens)		5 / 12
SER B 100
ASP B 107
GLY B  98
GLY B  99
GLN B   1
1.80A21.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_1
(ADENOSINE KINASE)		6yor IGG H CHAIN
(Homo
sapiens)		5 / 12
SER B 100
ASP B 107
GLY B  98
GLY B  99
GLN B   1
1.79A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_1
(ADENOSINE KINASE)		6yor IGG H CHAIN
(Homo
sapiens)		5 / 12
SER H 100
ASP H 107
GLY H  98
GLY H  99
GLN H   1
1.80A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_2
(ADENOSYLHOMOCYSTEINA
SE)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 5
GLN A 110
THR A 111
THR A 201
LEU A 250
1.34A
PEG  A 405 ( 3.9A)
CL  A 406 ( 3.6A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
ASP A 216
GLY A 283
LEU A 287
ASN A 214
GLY A   2
1.62A
None
None
PEG  A 404 (-2.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_2
(ADENOSINE KINASE)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		4 / 4
ALA A 206
VAL A 261
GLY A 258
THR A 257
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_1
(ADENOSYLHOMOCYSTEINA
SE)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
HIS A  41
LEU A  27
GLY A 146
HIS A 163
PHE A 181
1.80A19.88
PK8  A 401 (-3.2A)
PK8  A 401 ( 3.6A)
None
DMS  A 403 (-4.1A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		6yt8 REPLICASE
POLYPROTEIN 1AB
(SARS-CoV-2)		5 / 12
LEU A 205
VAL A 296
LEU A 250
ASN A 214
GLY A 215
1.69A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU B 126
GLY B  47
GLY B  48
ASN E 101
GLY E 103
1.25A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU E 126
GLY B  47
GLY B  46
ASN E  99
GLY E 103
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ASN B  54
LEU B  88
GLY B  48
GLY B  51
ASN E 101
1.56A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ASN B  54
LEU B  88
GLY B  47
GLY B  51
ASN E 101
1.54A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ASN D 115
LEU D 122
ASN A 115
LEU D  93
GLY A  78
1.71A
EDO  D 201 (-3.6A)
None
EDO  D 201 (-3.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ASN E  37
LEU E  75
GLY E  47
LEU E  43
GLY E 130
1.66A
None
EPE  E 203 (-3.6A)
EPE  E 202 (-4.3A)
None
EPE  E 202 ( 4.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ASN B  37
LEU B  75
GLY B  47
LEU B  43
GLY B 130
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU E 109
GLY B  47
GLY B  46
VAL E 100
ASN B  40
1.40A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ASN D  37
LEU D  75
GLY D  47
LEU D  43
GLY D 130
1.66A
None
None
EDO  D 206 (-4.5A)
None
EDO  D 205 ( 4.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY C  85
ASN D 159
LEU C 123
ASN D  20
ASP D 162
1.59A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_1
(ADENOSINE KINASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY E 133
GLY B  47
ASN E 101
ALA B  38
GLY E 103
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ASN B  54
LEU B  43
GLY E 133
GLY B  47
ASN E 101
1.68A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ASN A  37
LEU A  75
GLY A  47
LEU A  43
GLY A 130
1.62A
None
None
None
None
EDO  A 202 ( 4.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ASN B  54
LEU B  88
GLY B  48
GLY B  47
ASN E 101
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU E 164
GLY E 133
ASN E 101
LEU E 126
GLY B  51
1.64A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU B 127
GLY B  47
GLY B  48
ASN E 101
GLY E 103
1.14A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		6ywk NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ASN C  37
LEU C  75
GLY C  47
LEU C  43
GLY C 130
1.67A
None
EPE  C 202 (-3.4A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU B 127
GLY B  47
GLY B  48
ASN E 101
GLY E 103
1.23A
None
APR  B 201 (-3.6A)
APR  B 201 (-3.5A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ASN B  40
GLY B  47
GLY B  46
LEU B  43
GLY E 130
1.54A
APR  B 201 (-3.8A)
APR  B 201 (-3.6A)
EDO  B 202 (-3.9A)
None
APR  E 201 (-3.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY C  85
ASN D 159
LEU C 123
ASN D  20
ASP D 162
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU B 127
GLY B  46
GLY B  47
ASN E 101
GLY E 103
1.42A
None
EDO  B 202 (-3.9A)
APR  B 201 (-3.6A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ASN A  54
LEU A  88
GLY A  47
GLY A  51
VAL A  49
1.62A
None
None
APR  A 201 (-4.1A)
None
APR  A 201 (-3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_1
(ADENOSINE KINASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY E 133
GLY B  46
ASN E 101
ALA B  38
GLY E 103
1.63A
None
EDO  B 202 (-3.9A)
None
APR  B 201 (-3.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU B 126
GLY B  47
GLY B  48
ASN E 101
GLY E 103
1.30A
APR  B 201 (-4.7A)
APR  B 201 (-3.6A)
APR  B 201 (-3.5A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_1
(ADENOSINE KINASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
GLY E 133
GLY B  47
ASN E 101
ALA B  38
GLY E 103
1.58A
None
APR  B 201 (-3.6A)
None
APR  B 201 (-3.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU E 109
GLY B  47
GLY B  46
VAL E 100
ASN B  40
1.56A
None
APR  B 201 (-3.6A)
EDO  B 202 (-3.9A)
None
APR  B 201 (-3.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ASN B  40
GLY B  51
GLY B  46
LEU B  43
GLY E 130
1.61A
APR  B 201 (-3.8A)
None
EDO  B 202 (-3.9A)
None
APR  E 201 (-3.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ASN E  54
LEU E  88
GLY E  47
GLY E  51
VAL E  49
1.67A
None
None
APR  E 201 (-4.4A)
None
APR  E 201 (-3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ASN D  54
LEU D  88
GLY D  47
GLY D  51
VAL D  49
1.68A
None
None
APR  D 201 ( 4.3A)
None
APR  D 201 (-3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
LEU E 126
GLY B  47
GLY B  46
ASN E  99
GLY E 103
1.48A
APR  E 201 (-4.7A)
APR  B 201 (-3.6A)
EDO  B 202 (-3.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		6ywl NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ASN D 115
LEU D 122
ASN A 115
LEU D  93
GLY A  78
1.69A
EDO  A 207 ( 3.7A)
None
EDO  A 207 (-3.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		6ywm NSP3 MACRODOMAIN
(SARS-CoV-2)		5 / 12
ASN B  37
LEU B  75
GLY B  47
LEU B  43
GLY B 130
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_2
(ADENOSYLHOMOCYSTEINA
SE)		7bqy MAIN PROTEASE
(SARS-CoV-2)		4 / 5
GLN A 110
THR A 111
THR A 201
LEU A 250
1.47A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		7bqy MAIN PROTEASE
(SARS-CoV-2)		5 / 12
LEU A 205
VAL A 296
LEU A 250
ASN A 214
GLY A 215
1.62A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_2
(ADENOSINE KINASE)		7bqy MAIN PROTEASE
(SARS-CoV-2)		4 / 4
ALA A 206
VAL A 261
GLY A 258
THR A 257
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_A_2FAA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		7btf NSP12
(SARS-CoV-2)		5 / 11
MET A 666
SER A 343
GLY A 345
VAL A 535
VAL A 354
1.57A13.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_B_2FAB301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		7btf NSP12
(SARS-CoV-2)		5 / 12
ARG A 392
SER A 672
VAL A 667
SER A 397
VAL A 675
1.75A13.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_2
(ADENOSINE KINASE)		7btf NSP12
(SARS-CoV-2)		4 / 4
ALA A 777
VAL A 764
GLY A 616
THR A 801
1.75A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		7btf NSP12
NSP8
(SARS-CoV-2)		5 / 12
LEU A 366
VAL A 373
LEU B  91
ASN A 356
GLY A 345
1.58A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		7btf NSP7
NSP8
(SARS-CoV-2)		5 / 12
ASN D 109
LEU D 128
GLY D 113
VAL D 131
GLY C  64
1.29A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_2
(ADENOSYLHOMOCYSTEINA
SE)		7btf NSP7
NSP8
(SARS-CoV-2)		4 / 5
GLN D  88
THR D  89
THR C   9
LEU C  56
1.42A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_2
(ADENOSINE KINASE)		7btf NSP7
(SARS-CoV-2)		4 / 4
ALA C  48
VAL C  53
PHE C  49
THR C   9
1.66A11.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_1
(ADENOSINE KINASE)		7btf NSP12
(SARS-CoV-2)		5 / 12
SER A 592
GLY A 596
GLY A 597
ASN A 600
GLN A 932
1.72A16.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_2
(ADENOSINE KINASE)		7btf NSP12
(SARS-CoV-2)		4 / 5
LEU A 514
ALA A 502
MET A 519
PHE A 506
1.55A17.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		7btf NSP12
(SARS-CoV-2)		5 / 12
LEU A 245
GLY A 214
ASN A 215
LEU A 186
ASP A 211
1.67A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		7btf NSP12
(SARS-CoV-2)		5 / 12
LEU A 727
GLY A 712
ASN A 713
LEU A 707
ASN A  39
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_1
(ADENOSINE KINASE)		7btf NSP12
(SARS-CoV-2)		5 / 12
SER A 592
GLY A 596
GLY A 597
ASN A 600
GLN A 932
1.71A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_2
(ADENOSYLHOMOCYSTEINA
SE)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		4 / 5
GLN A 110
THR A 111
THR A 201
LEU A 250
1.25A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_1
(ADENOSYLHOMOCYSTEINA
SE)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		5 / 12
HIS A  41
LEU A  27
GLY A 146
HIS A 163
PHE A 181
1.76A19.88
JRY  A 401 (-3.9A)
None
None
DMS  A 402 (-3.9A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_2
(ADENOSINE KINASE)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		4 / 4
ALA A 206
VAL A 261
GLY A 258
THR A 257
1.74A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		5 / 12
LEU A 205
VAL A 296
LEU A 250
ASN A 214
GLY A 215
1.65A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		7buy VIRUS MAIN PROTEASE
(SARS-CoV-2)		5 / 12
ASP A 216
GLY A 283
LEU A 287
ASN A 214
GLY A   2
1.66A
None
DMS  A 404 ( 4.5A)
None
None
DMS  A 404 (-3.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_1
(ADENOSINE KINASE)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
ASP A 135
GLY A 137
ASN A 138
PHE A 134
ASP A 140
1.75A16.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_2
(ADENOSYLHOMOCYSTEINA
SE)		7bv1 NSP7
NSP8
(SARS-CoV-2)		4 / 5
GLN D  88
THR D  89
THR C   9
LEU C  56
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
GLY A 352
ASN A 314
VAL A 354
LEU A 329
ASN A 300
1.66A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_2
(ADENOSINE KINASE)		7bv1 NSP12
(SARS-CoV-2)		4 / 5
LEU A 514
ALA A 502
MET A 519
PHE A 506
1.67A17.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_B_2FAB301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		7bv1 NSP12
(SARS-CoV-2)		5 / 12
ARG A 392
SER A 672
VAL A 667
SER A 397
VAL A 675
1.75A13.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_A_2FAA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		7bv1 NSP12
(SARS-CoV-2)		5 / 11
MET A 666
SER A 343
GLY A 345
VAL A 535
VAL A 354
1.57A13.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_2
(ADENOSINE KINASE)		7bv1 NSP7
(SARS-CoV-2)		4 / 4
ALA C  48
VAL C  53
PHE C  49
THR C   9
1.64A11.96
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		7bv1 NSP12
NSP8
(SARS-CoV-2)		5 / 12
LEU A 366
VAL A 373
LEU B  91
ASN A 356
GLY A 345
1.60A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_1
(ADENOSINE KINASE)		7bv2 NSP12
NSP8
(SARS-CoV-2)		5 / 12
SER A 384
GLY A 385
ASN A 386
MET B  94
ALA A 382
1.72A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_2
(ADENOSINE KINASE)		7bv2 NSP7
(SARS-CoV-2)		4 / 4
ALA C  48
VAL C  53
PHE C  49
THR C   9
1.74A11.96
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_2
(ADENOSINE KINASE)		7bv2 NSP12
(SARS-CoV-2)		4 / 5
LEU A 514
ALA A 502
MET A 519
PHE A 506
1.60A17.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_1
(ADENOSINE KINASE)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
GLY A 683
GLY A 559
GLN A 541
GLN A 408
GLY A 503
1.80A
 U  T  10 ( 3.1A)
U  T  10 ( 3.5A)
U  T   8 ( 3.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_2
(ADENOSYLHOMOCYSTEINA
SE)		7bv2 NSP12
(SARS-CoV-2)		4 / 5
GLN A 210
THR A 123
THR A 148
LEU A 178
1.70A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		7bv2 NSP12
NSP8
(SARS-CoV-2)		5 / 12
LEU A 366
VAL A 373
LEU B  91
ASN A 356
GLY A 345
1.63A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_2
(ADENOSINE KINASE)		7bv2 NSP12
(SARS-CoV-2)		4 / 4
ALA A 660
VAL A 662
GLY A 559
THR A 540
1.70A
None
None
U  T  10 ( 3.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_1
(ADENOSYLHOMOCYSTEINA
SE)		7bv2 NSP12
(SARS-CoV-2)		5 / 12
ASP A 477
LEU A 638
LEU A 575
GLY A 485
HIS A 642
1.78A20.69
None
None
None
None
ZN  A1002 (-3.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_2
(ADENOSINE KINASE)		7bv2 NSP12
(SARS-CoV-2)		4 / 4
ALA A 777
VAL A 764
GLY A 616
THR A 801
1.68A
None
None
MG  A1005 ( 4.6A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_1
(ADENOSINE KINASE)		7bv2 NSP12
NSP8
(SARS-CoV-2)		5 / 12
SER A 384
GLY A 385
ASN A 386
MET B  94
ALA A 382
1.73A16.37
None