Ligand ID: 1PC


Drugbank ID:
DB03575
(Phencyclidine)


Indication:

Get human targets for 1PC in PDB (known and potential targets)

RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES MAPPED TO LIGAND '1PC'

Click here for results that match SARS-Cov-2 / COVID-19 structures only
Click here for results that match SARS-related structures only


1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PCP_C_1PCC212_1
(IMMUNOGLOBULIN)		3d0h ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 10
HIS B 378
PHE B 274
TYR B 515
TYR B 510
HIS B 505
1.65A17.10
16.67
 ZN  B 901 (-3.8A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PCP_C_1PCC212_1
(IMMUNOGLOBULIN)		3sck ACE2
(Paguma
larvata;
Homo
sapiens;
SARSr-CoV)		5 / 10
HIS B 378
PHE B 274
TYR B 515
TYR B 510
HIS B 505
1.72A17.10
17.37
 ZN  B 901 (-3.7A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PCP_B_1PCB227_1
(IMMUNOGLOBULIN)		5x4r S PROTEIN
(MERS-CoV)		5 / 9
PHE A  75
GLY A  73
TYR A  71
TYR A  58
TYR A  64
1.78A19.94
21.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PCP_C_1PCC212_1
(IMMUNOGLOBULIN)		6acj ACE2
(Homo
sapiens)		5 / 10
HIS D 378
PHE D 274
TYR D 515
TYR D 510
HIS D 505
1.67A17.64
16.96
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PCP_C_1PCC212_1
(IMMUNOGLOBULIN)		6vw1 ACE2
(Homo
sapiens)		5 / 10
HIS B 378
PHE B 274
TYR B 515
TYR B 510
HIS B 505
1.68A17.64
16.30
 ZN  B 703 ( 4.6A)
None
None
None
None