SIMILAR PATTERN OF AMINO ACIDS MAPPED TO UNIPROT ID 'Q692E5'

DrReposER ID / Desc. Drug Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIX_B_OQRB302_0
(SULFOTRANSFERASE)		Oxamniquine2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 10
LEU X  14
VAL U  21
ASP U  29
PHE U  16
SER X  11
1.80A17.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TAJ_A_NBOA700_1
(LACTOTRANSFERRIN)		Nabumetone2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 7
THR H 111
GLY H 109
PRO H 107
THR H 102
1.08A17.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_A_ADNA506_1
(ADENOSYLHOMOCYSTEINA
SE)		Adenosine2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 12
THR R  47
GLU R  66
THR R 101
LEU K  45
HIS L  48
1.73A14.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA820_0
(GEPHYRIN)		Acetic acid2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 5
GLU Q  60
PRO Q  59
THR Q  58
MET L  63
1.73A18.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_A_RITA500_1
(PROTEASE)		Ritonavir2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 12
ARG B  78
ASP A  91
GLY A  69
PRO A  59
THR A  58
1.39A24.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFX_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		Crizotinib2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 8
LEU U  75
ALA U  26
GLY U 109
LEU U  31
GLY U  35
1.44A20.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		Salicylic acid2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 7
LEU J  31
TYR J  30
ILE J  38
GLY J 109
1.37A13.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_H_BEZH501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		Benzoic Acid2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 7
ASN W 105
VAL W 108
TYR W  27
ARG W 113
1.56A18.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E22_B_LOCB700_1
(TUBULIN ALPHA-1C
CHAIN
TUBULIN BETA-2B
CHAIN)		Colchicine2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		3 / 3
SER H  15
ALA H  20
VAL H  21
0.94A16.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_3
(-)		Acarbose2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		3 / 3
ASP B 106
ASP B  29
ASN K  40
1.23A13.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_H_ACTH3006_0
(BETA-CARBONIC
ANHYDRASE)		Acetic acid2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 6
GLN M  53
CYH M 117
VAL M 119
CYH M 128
1.17A21.17
None
ZN  M 999 (-2.3A)
None
ZN  M 999 (-2.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		Benzoic Acid2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 8
PHE H  16
ALA H  18
PRO B   8
LEU B  14
1.51A21.52
6.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_A_SAMA401_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		S-Adenosylmethionine2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 12
GLY D  70
GLY D  94
VAL D 108
VAL D  97
ASN D  10
1.33A16.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB5_A_NMYA301_0
(AAC(3)-IIIB PROTEIN)		Framycetin2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 11
ASP S  22
THR X  58
HIS X  48
THR X  49
GLY X  50
1.73A17.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		Bortezomib2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 9
SER J  67
THR J  56
GLY J  69
GLY J  70
ASP J  91
1.23A20.47
19.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_A_SAMA201_0
(YAEB-LIKE PROTEIN
RPA0152)		S-Adenosylmethionine2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 12
LEU X  75
CYH X  79
THR Q  12
SER Q  15
LEU X  14
1.55A20.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC0_A_RBFA303_2
(RIBOFLAVIN
TRANSPORTER RIBU)		Riboflavin2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		3 / 3
LYS G  89
LEU G  75
ILE G  81
0.97A19.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_B_J01B1436_1
(ORF12)		Clavulanate2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 9
HIS T  80
ILE T  81
ARG T  78
ALA T  71
LYS T  93
1.75A16.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		Pyridoxine2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 10
GLY C  69
ALA C  61
VAL D  42
CYH C  46
HIS C  48
1.74A19.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCL_A_AINA609_1
(LACTOPEROXIDASE)		Acetylsalicylic acid2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 6
HIS R  48
GLU L  66
PHE L  68
PRO L 107
1.09A13.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB200_0
(ILEAL BILE
ACID-BINDING PROTEIN)		Cholic Acid2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 5
PRO V 107
THR V  51
GLY V  52
LYS V  49
1.66A20.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_A_EPAA1_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		Icosapent2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 10
VAL C  13
PHE C  16
LEU C 112
VAL C 108
LEU C  75
1.44A20.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA501_1
(CYTOCHROME P450 2C8)		Alitretinoin2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 11
SER K  15
SER H  15
ALA B   9
THR B  39
VAL B  13
1.51A14.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G5J_A_0WMA1103_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		Afatinib2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 5
ASN L  62
MET L  63
HIS L  48
LEU R  45
1.80A17.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOI_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		Amphetamine2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 5
LEU N  92
ASP N  91
VAL N  97
ILE N  55
0.96A25.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMI_B_EF2B151_1
(CEREBLON ISOFORM 4)		Thalidomide2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 8
PRO O 107
PHE O  68
SER O  67
TRP O 123
1.49A23.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AK3_A_P2EA1201_0
(PROSTAGLANDIN E2
RECEPTOR EP3
SUBTYPE,SOLUBLE
CYTOCHROME B562)		Dinoprostone2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 12
GLN G  65
THR G 101
LEU H  45
SER G  67
GLN G  98
1.53A17.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXZ_A_0LIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		Ponatinib2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 12
ALA G  71
LEU H  45
VAL G  42
GLY H  94
HIS H  48
1.30A18.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXV_B_MTXB2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		Methotrexate2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 12
ALA L  26
SER L  15
ARG E  78
VAL L  21
ALA E   9
1.32A20.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)		Mifepristone2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 12
LEU J  92
GLY J  70
GLY J  69
VAL J  42
LEU J  75
1.53A19.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)		S-Adenosylmethionine2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		3 / 3
SER P  11
ALA P   9
THR P  39
1.74A17.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHC_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		Rifampicin2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		3 / 3
PHE N  89
ASP N  91
LEU T  92
1.21A8.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9N_B_CAMB1420_0
(CYTOCHROME P450)		Camphor2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 10
TYR P  76
LEU P 112
GLY P 109
ASP P  91
VAL P  97
1.78A16.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZY_A_CHDA237_0
(PHOSPHOLIPASE A2,
MAJOR ISOENZYME)		Cholic Acid2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 11
ILE T  81
HIS T  83
ASP R  82
LEU T  14
PHE R  19
1.78A18.63
None
ZN  T 998 (-3.3A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_B_SAMB1267_0
(NON-STRUCTURAL
PROTEIN 5)		S-Adenosylmethionine2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 12
SER L  72
GLY L  69
GLY K  70
GLY K  94
THR K 111
1.25A19.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_A_VDYA201_1
(CDL2.2)		Calcidiol2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 12
LEU Q  45
ILE R  38
GLU R  66
THR L 101
ALA R 104
1.53A22.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MLM_A_STRA401_1
(-)		Progesterone2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 12
LYS X   9
PHE U  16
ASN X  40
SER X  72
VAL U  21
1.33A16.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_D_CVID301_0
(PUTATIVE REGULATORY
PROTEIN)		Gentian Violet2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 12
LEU U  14
CYH U  79
THR X  12
SER Q  15
ILE U  38
1.55A17.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WQ5_A_MIYA1120_1
(PHOSPHOLIPASE A2,
ACIDIC)		Minocycline2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 7
LEU R  45
ALA L  61
GLY L  50
PHE Q  68
1.35A20.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IWK_B_CUB1599_0
(NITROUS OXIDE
REDUCTASE)		Copper2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		3 / 3
CYH P  77
CYH P  90
HIS P  83
1.31A13.97
 ZN  P 998 (-2.1A)
ZN  P 998 (-2.3A)
ZN  P 998 (-3.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROZ_A_NCAA266_0
(APOLIPOPROTEIN
A-I-BINDING PROTEIN)		Nicotinamide2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 6
ASP P  91
LEU P  92
LEU P 112
THR P 111
1.27A18.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)		Deoxycholic Acid2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 9
ASP S  91
VAL X 116
THR X 118
GLN X  53
GLY X 121
1.61A14.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UYM_B_VORB590_1
(14-ALPHA STEROL
DEMETHYLASE)		Voriconazole2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 7
TYR T  27
TYR T  30
ALA T   9
LEU T  14
1.33A16.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_C_SAMC300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		S-Adenosylmethionine2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 12
GLY X  52
GLY X 121
GLU X  60
ILE X  99
VAL X  97
1.45A20.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B68_D_9F2D400_1
(BETA-LACTAMASE)		Ceftriaxone2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 12
SER S  15
SER O  15
ARG S  78
THR O  12
THR S  12
1.75A22.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		S-Adenosylmethionine2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 12
THR K  56
GLY K  50
THR K  51
GLY K  52
THR R  49
1.17A14.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_1
(CYTOCHROME P450 2C8)		Montelukast2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 12
SER K  15
SER H  15
ALA B   9
THR B  39
VAL B  13
1.45A14.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_K_BO2K305_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-1)		Bortezomib2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 11
ALA P  54
THR P  56
GLY P  69
GLY P  70
ASP P  91
1.31A23.76
25.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_B_VDYB201_1
(CDL2.2)		Calcidiol2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 10
TYR R  27
ILE R  38
ILE R  99
PRO L 100
LEU R 112
1.58A22.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DPM_A_SAMA300_0
(PROTEIN
(ADENINE-SPECIFIC
METHYLTRANSFERASE
DPNII 1))		S-Adenosylmethionine2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 12
GLY I  94
GLY I  69
GLY I  70
ALA I  71
PHE J  68
1.43A17.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA802_1
(TRANSPORTER)		Clomipramine2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 6
ARG S  78
PHE O  19
ILE O  81
PHE W  19
1.59A15.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		Chloramphenicol2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 10
THR R 101
ALA L 104
PHE L  68
ALA R 104
LEU Q  45
1.67A21.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXV_A_MTXA2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		Methotrexate2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 12
ALA L  26
SER L  15
ARG E  78
VAL L  21
ALA E   9
1.37A20.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_A_IBPA1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		Ibuprofen2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 7
ILE H  55
LEU H  92
GLY H  69
GLY H  94
THR H  56
1.67A14.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EXS_B_X8ZB301_1
(BETA-LACTAMASE NDM-1)		Captopril2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 8
VAL T  57
HIS T  48
CYH T  46
ASN S  40
1.47A18.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9N_A_CAMA1419_0
(CYTOCHROME P450)		Camphor2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 8
THR L 111
LEU L  92
GLY L  70
VAL L 108
1.24A16.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		Metyrapone2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 6
ARG L 113
ILE L  99
ALA L 104
THR R 101
1.40A15.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TYL_C_TYLC100_1
(INSULIN)		Acetaminophen2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 5
CYH G  73
ILE G  38
CYH G  41
ALA G 104
1.59A13.04
15.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		Ketoconazole2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 12
ARG S  78
SER S  11
LEU O  14
PHE W  19
ALA O  26
1.48A15.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FN1_A_SALA506_1
(SALICYLATE
SYNTHETASE, IRP9)		Salicylic acid2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 11
GLY L  50
THR L  49
GLU L  60
HIS Q  48
LEU R  45
1.73A16.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FH2_A_0RNA303_1
(BETA-LACTAMASE SHV-1)		Sulbactam2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 10
TYR F  76
ASN F  85
VAL F 108
GLY F  70
ALA F  71
1.52A20.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_B_ADNB401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		Adenosine2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 12
GLN J  98
GLY J  94
ILE J  55
ASP J  91
CYH J  73
1.42A17.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		Bortezomib2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 10
THR J  56
ALA J  54
GLY J  69
GLY J  70
ASP J  91
1.66A19.09
19.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN)		S-Adenosylmethionine2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 12
SER R  72
GLY R  69
ALA Q  71
GLY Q  69
TYR Q  96
1.47A20.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_A_ADNA401_2
(ADENOSINE KINASE,
PUTATIVE)		Adenosine2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 5
LEU S  14
ALA O  20
PHE O  16
ASN S  40
1.78A17.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DPZ_A_TYLA2001_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		Acetaminophen2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 6
LEU Q  45
ALA L  61
HIS R  48
LYS R  43
1.73A23.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YOA_A_017A100_1
(HIV-1 PROTEASE)		Darunavir2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 6
ASN U  40
PRO V  59
THR V  58
VAL Q  21
1.50A23.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_0
(VP39)		S-Adenosylmethionine2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 12
ILE H  55
GLY H  50
HIS H  48
VAL H  97
LEU H  92
1.26A17.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_A_CELA682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		Celecoxib2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 8
SER P  15
LEU P 112
ARG P  78
ILE P  81
1.24A13.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBX_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		Adenosine2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 12
GLY H  70
GLY H  69
SER H  67
LEU G  45
THR H  56
1.56A16.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B6E_A_9F2A302_1
(BETA-LACTAMASE)		Ceftriaxone2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 12
ILE D  99
THR D  56
THR D  51
GLY D  52
GLY D 127
1.40A22.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)		Tetracycline2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 7
THR Q 111
PRO Q 107
VAL Q  42
LEU Q  14
1.19A16.89
17.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_D_ACTD404_0
(L-LYSINE
3-HYDROXYLASE)		Acetic acid2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 6
GLU A  66
HIS A  48
ALA A  61
GLN A  98
1.56A17.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GLU_A_SAMA301_0
(YCGJ)		S-Adenosylmethionine2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 12
GLY L  52
GLY L  50
HIS Q  48
THR L  58
ALA L  54
1.26A22.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A79_A_P1BA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		Pioglitazone2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 12
LEU U  75
LEU U  31
ILE U  38
GLN U  36
TYR U  30
1.51A14.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_D_ADND303_1
(5'/3'-NUCLEOTIDASE
SURE)		Adenosine2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 10
LEU U  75
LEU U 112
GLY U 109
ASP U  29
ALA U  20
1.61A19.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RV7_B_AB1B1001_1
(PROTEASE)		Lopinavir2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 11
ASN R  10
THR Q  58
PRO Q  59
VAL M  21
THR L 102
1.41A23.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		Ciprofloxacin2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 6
ARG E  78
SER E  11
THR F  51
GLU F  60
1.61A14.69
19.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GLU_B_SAMB302_0
(YCGJ)		S-Adenosylmethionine2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 12
GLY L  52
GLY L  50
HIS Q  48
THR L  58
ALA L  54
1.27A22.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_A_0LIA1772_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		Ponatinib2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 12
VAL H  21
ALA H  20
GLU A  60
ALA B   9
GLY A  50
1.38A17.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3N_B_ADNB505_1
(-)		Adenosine2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 12
THR R  47
GLU R  66
THR R 101
LEU K  45
HIS L  48
1.73A15.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_G_SAMG302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		S-Adenosylmethionine2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 12
GLY J  94
GLY J  70
SER J  72
VAL J  42
ASP J  91
1.31A20.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_A_DVAA6_0
(GRAMICIDIN D)		L-Valine2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		3 / 3
ALA P  61
VAL P  97
TRP P 123
1.61A6.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_A_ADNA500_2
(ADENOSYLHOMOCYSTEINA
SE)		Adenosine2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 5
GLN B  53
THR B  56
THR B  47
HIS B  48
1.50A15.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P2Y_A_NCTA440_1
(CYTOCHROME P450-CAM)		Nicotine2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 7
LEU P 112
VAL P 108
GLY P 109
ASP P  91
VAL P  97
1.59A15.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQ5_C_PAUC6002_0
(PANTOTHENATE KINASE)		Pantothenic acid2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 9
LEU M  31
GLY M 109
LEU M 112
TYR M 126
ILE M  99
1.58A20.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_C_ADNC501_2
(-)		Adenosine2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 5
GLN L  65
THR L 101
THR R  39
GLY L 127
1.34A15.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE1_A_X2NA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		Posaconazole2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 5
VAL G  13
TYR H  96
ILE H  55
PRO D  23
1.48A12.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		Aliskiren2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 12
VAL B  13
GLY B 109
ALA B   9
ASP B 106
ILE B  99
1.48A17.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN)		S-Adenosylmethionine2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 12
SER R  72
GLY R  69
ALA Q  71
GLY Q  69
TYR Q  96
1.43A20.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAY_A_ADNA1001_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		Adenosine2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 11
GLY C  34
ALA C  32
SER C  33
ASP C 106
VAL C  13
1.46A18.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_D_D16D402_1
(THYMIDYLATE SYNTHASE)		Raltitrexed2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 10
ILE P  99
LEU P  92
PHE P  68
TYR P  76
LYS P  95
1.72A18.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_B_29SB601_2
(ESTROGEN RECEPTOR)		Bazedoxifene2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 5
LEU E  45
GLU E  66
MET E  63
HIS E  48
1.65A17.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAY_B_ADNB1002_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		Adenosine2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 10
GLY C  34
ALA C  32
SER C  33
ASP C 106
VAL C  13
1.50A18.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N3H_A_NCAA401_0
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA)		Nicotinamide2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 10
VAL X 116
ALA X  54
VAL X  97
LEU X  92
THR X 111
1.59A18.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		Nelfinavir2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		3 / 3
ARG R  78
ASN R  85
THR R 111
1.41A21.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_A_RGZA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		Rosiglitazone2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 11
LEU U  75
LEU U  31
ILE U  38
GLN U  36
TYR U  30
1.50A14.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJW_A_SRYA2001_2
(TRANSCRIPTIONAL
REGULATOR TCAR)		Streptomycin2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 6
ILE K  38
ASN K  10
HIS K  80
VAL L  57
1.35A19.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FI4_B_DVAB8_0
(14-3-3 PROTEIN SIGMA
PRO-SEP-LEU-PRO-DVA)		L-Valine2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 5
SER B  11
LYS B   8
ASN B  40
PRO H  23
1.76A17.94
3.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		Pyridoxal2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 9
GLY I  69
ALA I  71
GLY I  70
VAL I  42
VAL I 108
1.79A19.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_B_ADNB501_2
(-)		Adenosine2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 5
GLN B  53
THR B  56
THR B  47
HIS B  48
1.53A15.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_A_SAMA201_1
(YAEB-LIKE PROTEIN
RPA0152)		S-Adenosylmethionine2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 5
SER G  67
ARG H  78
ASP K  22
THR G  51
1.72A20.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_2
(TRANSPORTER)		Paroxetine2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		3 / 3
SER P  67
MET P  44
ASP P 106
1.41A14.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		Pemetrexed2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 12
ALA X  18
PHE X  16
SER X  33
LEU X  31
TYR X  76
1.53A15.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		Acetylcholine2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 8
THR U  12
GLN U  36
TYR U  27
CYH U  17
1.76A20.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		Diclofenac2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 9
CYH P  41
SER P  72
ALA P  71
LEU P  75
ILE P  38
1.79A18.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_C_SAMC301_0
(UNCHARACTERIZED
PROTEIN)		S-Adenosylmethionine2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 12
SER R  72
GLY R  69
ALA Q  71
GLY Q  69
TYR Q  96
1.44A20.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAC_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		Crizotinib2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 10
LEU U  75
ALA U  26
GLY U 109
LEU U  31
GLY U  35
1.45A20.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKY_A_DR7A100_2
(PROTEASE)		Atazanavir2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 9
ARG C  78
ASP D  91
ILE D  55
GLY D  70
PRO D  59
1.79A22.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_A_ACTA304_0
(GLUTATHIONE
TRANSFERASE GTE1)		Acetic acid2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 5
ILE A  38
LEU A  14
LYS A   9
ASN A  40
0.99A19.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_K_6V8K305_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		Ixazomib2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 11
ALA P  54
THR P  56
GLY P  69
GLY P  70
ASP P  91
1.28A23.76
25.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		Colchicine2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		3 / 3
SER H  15
ALA H  20
VAL H  21
0.96A16.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_B_ADNB1502_1
(CLASS B ACID
PHOSPHATASE)		Adenosine2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 7
PHE K  16
THR K  12
TYR K  30
LYS K   9
1.76A21.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK6_A_LNLA1201_1
(NON-SPECIFIC LIPID
TRANSFER PROTEIN)		Alpha-Linolenic Acid2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 12
VAL A  13
LEU A  14
ASN A  10
LEU A  75
ALA A  24
1.24A20.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JR1_B_MOAB1333_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		Mycophenolic acid2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 8
ASN U 114
ARG U 113
GLY U 125
GLN U  65
1.26A16.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP4_A_MIIA2001_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		Meticillin2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 9
THR J  51
GLN J  65
ALA J  61
SER J  67
ASN I  40
1.66A19.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_B_HFGB1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		Halofuginone2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		3 / 3
THR L 101
GLU R  66
HIS L  48
1.44A13.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_C_REAC602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		Tretinoin2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 10
ILE H  38
GLY H 109
THR H 111
LEU H  75
LEU H  92
1.62A15.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UYQ_A_SAMA1311_0
(HYPOTHETICAL PROTEIN
ML2640)		S-Adenosylmethionine2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 7
GLY S  70
VAL S  97
LEU S 112
ARG S 113
1.18A18.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		Bortezomib2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 8
THR F  58
SER E  72
ALA L  20
SER E  11
1.35A20.18
18.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		S-Adenosylmethionine2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 12
VAL S 116
GLY S  70
GLY S  69
ILE S  55
ARG S  78
1.40A18.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_2
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		Lisinopril2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		3 / 3
ALA P   9
THR P  39
PHE N  16
1.64A13.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_C_ADNC438_2
(ADENOSYLHOMOCYSTEINA
SE)		Adenosine2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 5
GLN B  53
THR B  56
THR B  47
HIS B  48
1.51A14.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_B_CVIB301_0
(PUTATIVE REGULATORY
PROTEIN)		Gentian Violet2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 12
THR O  39
SER O  72
LEU O  14
LEU O 112
LEU O  31
1.37A17.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERS_A_ACTA803_0
(GEPHYRIN)		Acetic acid2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		3 / 3
THR B  39
ALA B   9
ASN B  40
0.81A18.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB513_1
(HEMOLYTIC LECTIN
CEL-III)		Lactulose2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 6
CYH J  74
CYH J  90
ASP J  91
ILE J  55
1.44A17.28
 ZN  J 998 (-2.2A)
ZN  J 998 (-2.3A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YN6_A_SAMA401_0
(NSP16 PROTEIN)		S-Adenosylmethionine2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 12
GLY F  94
GLY E  70
LEU F  92
ASP F  91
PHE F  89
1.37A19.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)		Mifepristone2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 12
LEU J  92
GLY J  70
GLY J  69
VAL J  42
LEU J  75
1.54A19.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XPQ_A_SPMA924_1
(FMS1 PROTEIN)		Spermine2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 11
PHE C  19
LEU A  75
PHE F  19
LEU A  14
TYR A  76
1.80A14.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_A_ACTA204_0
(N-ACETYLTRANSFERASE)		Acetic acid2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 5
LEU A  75
CYH A  74
THR A 111
GLY A 109
1.47A20.00
None
ZN  A 998 (-2.2A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZE_A_BAXA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		Sorafenib2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 12
VAL F  42
LEU F  14
VAL C  21
GLY E  94
HIS F  83
1.26A19.03
None
None
None
None
ZN  F 998 (-3.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_A_SAMA1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		S-Adenosylmethionine2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 12
LYS K  43
MET K  44
TYR K  96
ALA K 104
ASN K 105
1.66A22.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3003_0
(BETA-CARBONIC
ANHYDRASE)		Acetic acid2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 8
GLN M  53
CYH M 117
VAL M 119
CYH M 128
1.22A21.17
None
ZN  M 999 (-2.3A)
None
ZN  M 999 (-2.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_B_BO2B201_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-2)		Bortezomib2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 12
SER G  67
THR G 101
ALA G 104
ALA G  61
THR G  49
1.54A21.50
19.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDI_A_SAMA601_0
(METHYLTRANSFERASE)		S-Adenosylmethionine2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 12
PHE L  68
GLU L  66
ALA L 104
THR R 101
ILE R  99
1.66A17.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		Fludarabine2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 12
ASN T 114
GLY T 127
THR T 102
ASN T  62
GLY T  52
1.38A17.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AK3_B_P2EB1201_0
(PROSTAGLANDIN E2
RECEPTOR EP3
SUBTYPE,SOLUBLE
CYTOCHROME B562)		Dinoprostone2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 12
GLN G  65
THR G 101
LEU H  45
SER G  67
GLN G  98
1.54A17.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQL_A_TXCA1452_1
(GUANINE DEAMINASE)		Valaciclovir2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 12
LEU Q  45
LEU R  45
HIS R  48
GLU R  66
GLU L  66
1.64A14.73
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA200_0
(ILEAL BILE
ACID-BINDING PROTEIN)		Cholic Acid2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 5
PRO V 107
THR V  51
GLY V  52
LYS V  49
1.56A20.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_A_CHDA3_0
(FERROCHELATASE,
MITOCHONDRIAL)		Cholic Acid2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 7
MET M  44
PRO N  59
SER N  67
GLY N  94
1.31A16.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_B_VIBB504_1
(YKOF)		Thiamine2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 6
PRO M  84
HIS M  83
PHE T  19
ILE M  81
1.42A21.89
None
ZN  M 998 (-3.3A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA442_1
(ALPHA AMYLASE)		Acarbose2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 11
GLY X  52
GLY X 121
GLN X  53
GLY X 127
GLY X 125
1.73A13.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_A_STRA604_1
(CYTOCHROME P450
21-HYDROXYLASE)		Progesterone2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 12
VAL I  13
LEU I  14
ASP I 106
ILE I  38
LEU I 112
1.51A14.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_RALB600_2
(ESTROGEN RECEPTOR)		Raloxifene2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 4
LEU U 112
THR U 111
ILE U  81
HIS U  83
1.67A19.44
None
None
None
ZN  U 998 (-3.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIX_A_OQRA302_0
(SULFOTRANSFERASE)		Oxamniquine2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 9
PRO U  23
LEU X  14
ILE X  81
PHE Q  19
SER U  15
1.69A17.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_C_DXCC576_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		Deoxycholic Acid2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 8
PRO C 100
ALA C 104
PRO C 107
ILE C  99
THR C 111
1.53A12.85
17.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_A_SALA601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		Salicylic acid2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 7
LEU J  31
TYR J  30
ILE J  38
GLY J 109
1.34A13.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOT_A_VDNA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		Vardenafil2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 12
TYR U  76
HIS U  83
ILE U  81
SER U  15
ILE U  38
1.67A16.00
None
ZN  U 998 (-3.3A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HKU_A_TORA300_2
(CARBONIC ANHYDRASE 2)		Topiramate2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		3 / 3
GLU H  60
HIS H  48
THR H  51
1.22A19.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F80_B_017B301_1
(POL POLYPROTEIN)		Darunavir2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		6 / 12
LEU A  92
ASP A  91
ASN H  85
GLY A 121
VAL A  97
ILE A  55
1.75A22.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		Acetylcholine2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 8
THR H  56
GLN H  53
SER H  67
CYH H  46
1.47A20.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB4_0
(FERROCHELATASE)		Cholic Acid2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 6
MET O  44
ARG P  78
PRO P  59
GLY P  70
1.76A16.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9I_A_ADNA401_1
(SUGAR KINASE)		Adenosine2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 12
GLY H  70
GLY H  69
SER H  67
LEU G  45
THR H  56
1.56A16.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		Dexrazoxane2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 7
HIS R  48
THR L 101
ASN L  62
GLN L  65
1.18A15.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_3
(PHOSPHOLIPASE A2)		Suramin2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 12
LEU T 112
GLY T 109
ILE T  38
PHE T  68
SER T  72
1.59A22.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QOW_A_SAMA417_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE)		S-Adenosylmethionine2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		3 / 3
THR Q  47
ASP L  64
GLU R  66
1.30A16.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_A_WJZA304_0
(BETA-LACTAMASE NDM-1)		Tiopronin2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 8
VAL F  97
HIS F  83
CYH F  77
ASN F  85
1.58A19.75
None
ZN  F 998 (-3.3A)
ZN  F 998 (-2.2A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_A_SAMA4000_1
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		S-Adenosylmethionine2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		3 / 3
GLY H  50
GLU H  60
ASN H  62
1.58A22.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIA_B_SAMB206_0
(UPF0217 PROTEIN
MJ1640)		S-Adenosylmethionine2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 5
SER R  67
LEU R  92
GLY R  94
CYH R  73
1.53A19.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_1
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)		Framycetin2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 12
LEU E  75
TYR E  76
ASN I  40
PHE L  19
HIS I  80
1.78A15.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NKN_A_LOCA201_2
(NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN)		Colchicine2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		3 / 3
VAL D 108
LYS D  43
MET D  44
1.56A18.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI8_A_HNQA255_1
(CATHEPSIN B)		Nitroxoline2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 7
GLN R  65
GLY R  52
HIS R  48
CYH R  46
1.50A21.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA503_1
(CYTOCHROME P450 2C9)		Losartan2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 6
PHE H  16
PRO B   8
THR B  12
ASN B  10
1.42A15.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_B_SAMB3141_1
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		S-Adenosylmethionine2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		3 / 3
HIS P  80
ASP P  82
ASN P  85
1.25A21.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_2
(ADENOSYLHOMOCYSTEINA
SE)		Fludarabine2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 5
GLN B  53
THR B  56
THR B  47
HIS B  48
1.53A13.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW7_A_VPXA2001_1
(PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME)		Vorapaxar2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 12
HIS O  80
LEU O  14
LEU W  75
ALA W  26
ALA W  24
1.38A15.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PRS_A_RITA1001_1
(ENDOTHIAPEPSIN)		Ritonavir2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 10
ALA W   9
TYR W  27
THR W 111
ILE W  81
THR W  12
1.50A20.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_1
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		Halofuginone2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		3 / 3
THR L 101
GLU R  66
HIS L  48
1.48A14.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQT_A_AINA596_1
(LACTOPEROXIDASE)		Acetylsalicylic acid2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 6
HIS R  48
GLU L  66
PHE L  68
PRO L 107
1.06A13.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K93_A_ADNA401_1
(SUGAR KINASE)		Adenosine2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 12
GLY H  70
GLY H  69
SER H  67
LEU G  45
THR H  56
1.54A16.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_A_SAMA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		S-Adenosylmethionine2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 12
VAL S 116
GLY S  70
GLY S  69
ILE S  55
ARG S  78
1.37A18.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB203_0
(HYDROXYNITRILE LYASE)		Benzoic Acid2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 4
VAL H  21
ALA B   9
ILE B  38
THR B  39
1.60A20.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XP2_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		Crizotinib2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 9
LEU U  75
ALA U  26
GLY U 109
LEU U  31
GLY U  35
1.45A20.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_B_D16B402_1
(THYMIDYLATE SYNTHASE)		Raltitrexed2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 12
ILE T  99
TRP T 123
GLY T 109
TYR T  76
THR T  39
1.43A14.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_D_ADND500_1
(ADENOSYLHOMOCYSTEINA
SE)		Adenosine2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 12
HIS L  48
GLU L  66
THR L 101
LEU R  45
HIS R  48
1.47A13.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		Grazoprevir2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 12
GLY T 109
ALA T  24
ALA T  26
ALA T  20
SER M  11
1.25A22.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1N_A_CAMA1422_0
(CYTOCHROME P450-CAM)		Camphor2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		6 / 11
TYR B  76
LEU B 112
VAL B 108
GLY B 109
ASP B  91
VAL B  97
1.76A16.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXT_A_MTXA2000_1
(ANTI-METHOTREXATE
CDR1-3 GRAFT VHH)		Methotrexate2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 12
ALA N  26
SER N  15
ARG P  78
VAL N  21
ALA P   9
1.51A21.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		Cyclothiazide2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 11
ILE L  38
SER L  72
PRO L 107
LEU L  75
LEU L  92
1.48A9.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_A_SAMA306_1
(METHYLTRANSFERASE)		S-Adenosylmethionine2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 7
LEU Q  45
ILE L  99
GLU L  66
ASP L  64
1.18A22.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_A_HFGA802_1
(PROLINE--TRNA LIGASE)		Halofuginone2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 4
THR M  58
GLU M  60
THR M  47
HIS M  48
1.50A13.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_D_ADND438_1
(ADENOSYLHOMOCYSTEINA
SE)		Adenosine2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 12
HIS L  48
THR L 101
LEU Q  45
LEU R  45
HIS R  48
1.34A14.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_1
(ADENOSYLHOMOCYSTEINA
SE)		Ribavirin2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 12
THR R  47
GLU R  66
THR R 101
LEU K  45
HIS L  48
1.73A19.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MYU_A_VIBA500_1
(HIGH AFFINITY
TRANSPORT SYSTEM
PROTEIN P37)		Thiamine2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 10
ASN B  10
TYR B  27
ASP B 106
TYR B  30
GLY B  34
1.55A17.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0I_B_ACTB303_0
(SWI5-DEPENDENT HO
EXPRESSION PROTEIN 2)		Acetic acid2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 5
VAL F  97
THR F 111
ASP F  91
LEU F  92
1.43A20.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YI4_A_ADNA306_1
(PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		Adenosine2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 10
LEU L  14
PHE E  19
ALA I  20
ARG L  78
ILE I  81
1.43A16.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		Sorbitol2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 7
ILE M  38
CYH M  79
LEU M  75
GLY M 109
1.29A18.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1M_B_CAMB2422_0
(CYTOCHROME P450-CAM)		Camphor2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 8
PHE F 110
THR F 115
GLY F 121
VAL F  97
ILE F  99
1.76A16.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKK_A_SAMA301_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		S-Adenosylmethionine2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 12
GLY L  52
GLY L  50
GLU L  60
ALA L  54
THR Q  49
1.44A23.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL0_A_1UNA201_2
(PROTEASE)		Nelfinavir2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 9
ASP J  91
VAL J  97
ILE J  99
GLY J 109
ALA J  71
1.39A22.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_A_RABA602_2
(ADENOSYLHOMOCYSTEINA
SE)		Vidarabine2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 5
GLN B  53
THR B  56
THR B  47
HIS B  48
1.51A16.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		S-Adenosylmethionine2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 12
THR K  56
GLY K  50
THR K  51
GLY K  52
THR R  49
1.18A14.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3N_A_ADNA505_2
(-)		Adenosine2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 4
GLN B  53
THR B  56
THR B  47
HIS B  48
1.49A15.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_A_ADNA433_1
(ADENOSYLHOMOCYSTEINA
SE)		Adenosine2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 12
HIS L  48
THR L  49
GLU Q  66
HIS R  48
LEU Q  45
1.51A18.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXV_E_MTXE2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		Methotrexate2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 12
ALA L  26
SER L  15
ARG E  78
VAL L  21
ALA E   9
1.38A20.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_D_IMND476_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		Indomethacin2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 12
CYH N  74
PRO N  84
ILE N  38
VAL N 108
LEU N  31
1.39A17.79
 ZN  N 998 (-2.2A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		Imatinib2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 6
VAL U 108
VAL U  42
ILE U  99
MET V  44
1.66A18.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_A_TRPA601_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		L-Tryptophan2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 12
THR Q  47
GLY L  52
THR L  51
GLU L  60
CYH Q  46
1.57A13.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ASD_A_BAXA1500_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		Sorafenib2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 12
VAL J  42
LEU J  14
VAL G  21
GLY I  94
HIS J  83
1.21A18.70
None
None
None
None
ZN  J 998 (-3.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4C_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		Camphor2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 8
TYR J  76
LEU J 112
VAL J 108
VAL J  97
ASP J  91
1.77A16.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B6D_A_9F2A302_1
(BETA-LACTAMASE)		Ceftriaxone2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 12
ILE D  99
THR D  56
THR D  51
GLY D  52
GLY D 127
1.48A22.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3V_A_TOPA193_1
(DIHYDROFOLATE
REDUCTASE)		Trimethoprim2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 5
ASP P  64
ILE P  99
PRO P 100
PHE P 110
1.69A19.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_B_ADNB500_2
(ADENOSYLHOMOCYSTEINA
SE)		Adenosine2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 5
GLN B  53
THR B  56
THR B  47
HIS B  48
1.44A13.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_A_J01A500_1
(ORF12)		Clavulanate2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 10
HIS T  80
ILE T  81
ARG T  78
ALA T  71
LYS T  93
1.78A16.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X08_A_ASCA1253_0
(CYTOCHROME C
PEROXIDASE,
MITOCHONDRIAL)		Vitamin C2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 9
ILE L  81
PRO L  23
VAL L  21
ASN E  10
ARG E  78
1.75A19.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CD2_A_MTXA307_1
(DIHYDROFOLATE
REDUCTASE)		Methotrexate2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 12
LEU B  14
SER K  15
PRO B   8
PHE H  16
ILE H  81
1.62A18.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL6_A_NIMA614_1
(LACTOPEROXIDASE)		Nimesulide2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 7
HIS R  48
GLU L  66
PHE L  68
PRO L 107
0.68A13.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_B_032B401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		Vemurafenib2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 12
GLY O  35
ILE O  99
THR O 111
ALA O  24
GLY O  69
1.49A20.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_A_377A402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		Memantine2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 9
ALA V  18
SER V  15
ALA V  20
SER N  11
ALA V  26
1.42A17.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DR2_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		L-Tryptophan2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 11
GLY D  52
GLY D  50
GLN D  98
CYH D 120
GLN D  53
1.70A13.93
None
None
None
ZN  D 999 (-2.1A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_C_ADNC500_1
(ADENOSYLHOMOCYSTEINA
SE)		Adenosine2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 12
HIS L  48
THR L 101
LEU Q  45
LEU R  45
HIS R  48
1.37A15.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRJ_E_CAME503_0
(CAMPHOR
5-MONOOXYGENASE)		Camphor2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 6
TYR S  76
LEU S 112
VAL S 108
ASP S  91
1.47A15.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRL_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		Camphor2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 7
TYR J  76
LEU J 112
VAL J 108
VAL J  97
ASP J  91
1.78A15.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_A_ADNA401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		Adenosine2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 12
GLN J  98
GLY J  94
ILE J  55
ASP J  91
CYH J  73
1.42A17.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IJ7_C_TPFC2471_1
(CYTOCHROME P450 121)		Fluconazole2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 8
THR M  56
VAL M  57
VAL V  21
ALA V  24
1.27A15.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_4
(PROTEASE RETROPEPSIN)		Nelfinavir2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		3 / 3
ASP R  64
ASN R  62
THR K  49
1.10A21.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		Adenosine2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 4
GLN L  65
THR L 101
LEU R  45
LEU Q  45
1.56A15.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_B_486B801_1
(GLUCOCORTICOID
RECEPTOR)		Mifepristone2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 12
VAL H 119
ARG D 113
PHE D 110
GLN D  65
CYH D 128
1.77A19.08
 ZN  H 999 ( 4.8A)
None
None
None
ZN  D 999 (-1.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA502_1
(CYTOCHROME P450 2C9)		Losartan2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 6
GLY F  52
THR F  51
ASN F  62
LYS F  49
1.51A15.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXA_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		Adenosine2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 5
THR R  39
THR L 101
HIS R  48
LEU Q  45
1.70A19.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UGR_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		Indomethacin2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 7
ASN G  85
TYR G  27
PRO G  84
TYR G  76
1.63A19.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_B_VD3B2001_1
(VITAMIN D
HYDROXYLASE)		Cholecalciferol2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 11
THR L 101
ILE R  99
LEU Q  45
ASN L  62
PRO R 107
1.53A19.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KKY_X_CAMX503_0
(CAMPHOR
5-MONOOXYGENASE)		Camphor2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 6
TYR S  76
LEU S 112
VAL S 108
ASP S  91
1.52A14.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ8_A_CAMA503_0
(CYTOCHROME P450-CAM)		Camphor2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 9
TYR B  76
LEU B 112
VAL B 108
GLY B 109
ASP B  91
1.68A16.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQ5_A_PAUA6001_0
(PANTOTHENATE KINASE)		Pantothenic acid2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 9
LEU M  31
GLY M 109
LEU M 112
TYR M 126
ILE M  99
1.58A20.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		Mitoxantrone2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 12
GLY L 127
THR Q  49
ASN L  62
MET L  63
ASP L  64
1.56A18.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA302_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		Hydralazine2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 6
LEU B  14
PRO B   8
ARG B  78
HIS B  80
1.69A18.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWG_A_CAMA420_0
(CAMPHOR
5-MONOOXYGENASE)		Camphor2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 6
TYR R  76
LEU R 112
VAL R 108
ASP R  91
1.46A16.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O5Y_H_STRH249_1
(CHIMERIC ANTIBODY
FAB 1E9-DB3)		Progesterone2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 7
GLY P 121
THR P 118
MET P 122
SER P 129
1.27A21.65
21.12
None
None
None
ZN  P 999 ( 3.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_B_CELB682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		Celecoxib2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 7
SER P  15
LEU P 112
ARG P  78
ILE P  81
1.25A13.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3A_B_TOPB1189_1
(DIHYDROFOLATE
REDUCTASE)		Trimethoprim2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 10
ALA R 104
GLU R  66
THR R 111
ILE R  55
THR L 101
1.68A18.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMF_A_6U9A1301_1
(ION TRANSPORT
PROTEIN)		Nimodipine2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 6
THR P  51
GLY P  52
GLU P  60
ILE P  99
1.00A18.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R24_A_SAMA302_0
(2'-O-METHYL
TRANSFERASE)		S-Adenosylmethionine2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 12
GLY F  94
GLY E  70
LEU F  92
ASP F  91
PHE F  89
1.31A18.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQ5_D_PAUD6004_0
(PANTOTHENATE KINASE)		Pantothenic acid2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 10
LEU M  31
GLY M 109
LEU M 112
TYR M 126
ILE M  99
1.57A20.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_D_D16D609_1
(THYMIDYLATE SYNTHASE)		Raltitrexed2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 9
ILE L  99
TRP L 123
GLY L 109
TYR L  76
THR L  39
1.43A18.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GSD_A_STRA401_0
(PROGESTERONE
5-BETA-REDUCTASE)		Progesterone2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 12
LYS O   9
PHE W  16
ASN O  40
SER O  72
VAL W  21
1.49A18.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IX9_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)		Methotrexate2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 12
LEU M 112
GLN M  36
LYS M   9
ARG M  78
LEU M  14
1.37A18.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1Y_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		Colchicine2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		3 / 3
SER H  15
ALA H  20
VAL H  21
1.19A16.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHX_A_RTZA3009_1
(ALDEHYDE OXIDASE)		Thioridazine2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 8
HIS B  80
SER B  11
ARG B  78
PRO B   8
1.65A7.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		Cyclothiazide2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 11
ILE L  38
SER L  72
PRO L 107
LEU L  75
LEU L  92
1.48A9.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQB_B_IBPB706_1
(ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN 1
ENVELOPE
GLYCOPROTEIN 2)		Ibuprofen2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 8
ALA L  61
LEU L  45
LEU K  45
LEU Q  45
LEU R  45
1.10A17.45
20.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4Y_A_TPVA501_1
(PROTEIN (HIV-1
PROTEASE))		Tipranavir2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 10
ARG C  78
ALA C  26
ASP C  29
GLY C  35
VAL C 108
1.48A23.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_A_EPAA502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		Icosapent2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 10
PRO U 107
LEU U  75
ALA U  20
VAL U  13
PRO U  37
1.48A17.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILT_H_TRUH800_1
(GLUTAMATE RECEPTOR 2)		Trichlormethiazide2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		3 / 3
ILE Q  38
SER Q  11
SER Q  15
0.97A18.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		Imatinib2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 6
VAL U 108
VAL U  42
ILE U  99
MET V  44
1.63A18.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYZ_A_CCSA109_0
(CELLULOSOME-RELATED
PROTEIN MODULE FROM
RUMINOCOCCUS
FLAVEFACIENS THAT
RESEMBLES
PAPAIN-LIKE CYSTEINE
PEPTIDASES)		Carbocisteine2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 8
VAL R 108
ILE R  38
SER R  72
ALA M  20
1.21A21.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_B_SAMB500_1
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		S-Adenosylmethionine2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 8
PHE S  68
SER S  72
ARG S  78
ALA S 104
1.58A19.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_D_ADND500_1
(ADENOSYLHOMOCYSTEINA
SE)		Adenosine2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 12
HIS L  48
THR L 101
LEU Q  45
LEU R  45
HIS R  48
1.36A15.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA503_1
(CYTOCHROME P450 2C9)		Losartan2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 5
GLY F  52
THR F  51
ASN F  62
LYS F  49
1.56A15.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		Mercaptopurine2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 8
PHE U  16
THR X  12
LEU X  14
ALA U  18
1.22A13.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC503_0
(ADENOSYLHOMOCYSTEINA
SE)		Adenosine2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 12
GLY D  70
GLY D  94
ASP D  91
CYH D  90
ILE D  99
1.74A15.37
None
None
None
ZN  D 998 (-2.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ6_B_CAMB502_0
(CYTOCHROME P450-CAM)		Camphor2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 5
TYR J  76
VAL J 108
VAL J  97
ASP J  91
1.74A16.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		Benzoic Acid2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 7
PHE H  16
ALA H  18
PRO B   8
LEU B  14
1.45A21.52
6.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_2
(BETA-LACTAMASE)		Cefoxitin2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 5
TYR S  30
LEU S 112
THR S  39
ARG S  78
1.77A21.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHQ_A_SAMA301_0
(CATECHOL
O-METHYLTRANSFERASE)		S-Adenosylmethionine2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 12
VAL T  13
TYR T  30
ASN M  40
HIS M  80
ASP T  82
1.69A20.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ9_B_CAMB502_0
(CYTOCHROME P450-CAM)		Camphor2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 9
TYR B  76
LEU B 112
VAL B 108
GLY B 109
ASP B  91
1.70A16.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_2
(TRANSTHYRETIN)		Levothyroxine2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 7
LEU H  45
SER H  67
THR H  58
VAL D  21
1.31A23.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_A_MRVA1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		Maraviroc2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 7
TYR K  96
GLN L  36
THR R 102
THR R  49
1.40A14.73
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM0_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		Cyclothiazide2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 9
GLY R  50
MET R  44
SER R  67
LEU K  45
LEU R  45
1.65A9.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQ5_B_PAUB6003_0
(PANTOTHENATE KINASE)		Pantothenic acid2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 10
LEU M  31
GLY M 109
LEU M 112
TYR M 126
ILE M  99
1.57A20.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P6H_A_IBPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		Ibuprofen2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 7
ASP R  64
ILE L  38
VAL L  13
TYR L  30
1.61A19.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP5_A_KANA2001_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		Kanamycin2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 11
VAL D  21
THR H  58
GLN H  98
ALA H  61
SER H  67
1.66A19.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_A_ADNA438_2
(ADENOSYLHOMOCYSTEINA
SE)		Adenosine2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 4
GLN B  53
THR B  56
THR B  47
HIS B  48
1.53A14.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_B_ADNB438_1
(ADENOSYLHOMOCYSTEINA
SE)		Adenosine2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 12
HIS L  48
THR L 101
LEU Q  45
LEU R  45
HIS R  48
1.36A14.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_B_MTXB402_1
(THYMIDYLATE SYNTHASE)		Methotrexate2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 11
ILE X  99
LEU X  92
PHE X  68
TYR X  76
THR X  56
1.68A14.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWU_A_ACAA18_1
(WTFP-TAG,GP41)		Aminocaproic Acid2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 12
GLY U 127
SER U 129
LYS U  50
GLN U  53
GLU U  60
1.63A10.14
None
ZN  U 999 ( 4.0A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W4X_A_STZA1591_1
(O-GLCNACASE BT_4395)		Streptozocin2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 11
ASP D 106
TYR D  27
VAL D  13
ASN D  10
ASN D  40
1.63A12.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		Metyrapone2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		6 / 11
TYR P  76
LEU P 112
VAL P 108
GLY P 109
ASP P  91
VAL P  97
1.66A15.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_B_D16B409_1
(THYMIDYLATE SYNTHASE)		Raltitrexed2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 8
ILE T  99
TRP T 123
GLY T 109
TYR T  76
1.20A18.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E06_A_IPBA600_0
(ODORANT-BINDING
PROTEIN)		Thymol2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 6
VAL U 108
VAL Q  21
ASN U  40
ASN U  10
1.45A17.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_A_SAMA500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		S-Adenosylmethionine2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		3 / 3
HIS L  48
SER R  67
GLU R  66
1.08A18.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MQT_A_STIA302_1
(DEOXYCYTIDINE KINASE)		Imatinib2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 12
VAL H 108
TYR H  30
PRO B   8
ARG H  78
SER B  15
1.61A17.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4T_A_BEZA507_0
(BETA-LACTAMASE VIM-2)		Benzoic Acid2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		3 / 3
THR C  47
HIS C  48
ASN C  62
1.45A19.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_B_VDYB201_2
(CDL2.2)		Calcidiol2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 12
LEU Q  45
ILE R  38
GLU R  66
THR L 101
ALA R 104
1.47A22.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6APH_A_ADNA501_2
(ADENOSYLHOMOCYSTEINA
SE)		Adenosine2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 5
GLN Q  53
THR Q  56
THR Q  47
HIS Q  48
1.54A19.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA355_1
(PROTEIN (ADENOSINE
KINASE))		Adenosine2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 12
THR X  56
THR X  58
ILE X  99
GLY X  52
ALA X  61
1.39A15.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_B_TP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		Amitriptyline2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 12
PHE W  19
ARG S  78
HIS S  80
ALA S  18
SER O  15
1.64A22.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)		Levomefolic acid2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 12
ILE W  81
LEU W  31
ASP W 106
LYS W  93
ILE W  38
1.47A19.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CP4_A_CAMA416_0
(CYTOCHROME P450-CAM)		Camphor2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 10
TYR L  76
LEU L 112
VAL L 108
ASP L  91
VAL L  97
1.58A15.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJZ_A_BEZA1001_0
(BENZOATE-COENZYME A
LIGASE)		Benzoic Acid2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 8
VAL A  42
GLY B  94
ALA B  71
GLY B  69
MET B  44
1.50A15.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1A_A_AB1A101_2
(MDR769 HIV-1
PROTEASE)		Lopinavir2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 6
ARG S  78
GLY T  70
PRO T  59
THR T  58
1.50A23.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YME_H_CWBH1207_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		Granisetron2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 11
TYR M  96
SER N  72
CYH N  41
CYH N  73
THR M  47
1.78A19.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE506_1
(HEMOLYTIC LECTIN
CEL-III)		Lactulose2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 6
CYH X 117
THR X 115
CYH X 120
GLY X 121
1.72A17.28
 ZN  X 999 (-1.9A)
None
ZN  X 999 (-2.0A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB501_2
(PHOSPHOLIPASE A2)		Suramin2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 11
VAL P 116
ILE P  99
SER P  67
PRO P  59
THR P  56
1.58A22.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TD7_A_NFLA2001_1
(PHOSPHOLIPASE A2
ISOFORM 3)		Niflumic Acid2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 9
ILE P  99
TRP P 123
CYH P  41
TYR P  27
PHE P  68
1.78A21.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A8T_A_ADNA252_1
(U8 SNORNA-BINDING
PROTEIN X29)		Adenosine2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 9
ARG R  78
GLY R  70
PHE R  68
THR R 111
ILE R  38
1.54A19.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		Camphor2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 10
LEU F 112
THR F 115
ASP F  91
ILE F  55
VAL F 116
1.43A16.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4E_D_EDPD402_1
(PROTON-GATED ION
CHANNEL)		Thiopental2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 8
SER L  15
THR E  12
THR I  12
SER I  15
1.33A19.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHC_B_AB1B9001_1
(PROTEASE RETROPEPSIN)		Lopinavir2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 11
ARG U  78
ALA U  26
ASP U  29
GLY U  35
VAL U 108
1.47A21.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_B_ACTB502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		Acetic acid2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 5
LYS R  43
GLU R  66
THR L 101
ASP L  64
1.63A15.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3O_A_DLUA399_1
(PFV INTEGRASE)		Dolutegravir2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 7
PRO H 100
GLN H  65
GLU H  66
ARG H 113
1.71A16.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_A_IMNA379_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		Indomethacin2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 12
CYH C  74
PRO C  84
VAL C  13
TYR C  27
VAL C 108
1.67A17.79
 ZN  C 998 (-2.2A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QOW_A_SAMA417_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE)		S-Adenosylmethionine2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 12
GLY C  94
GLY D  70
VAL D  42
LYS D  89
ASP D  91
1.50A16.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0I_A_BEZA990_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		Benzoic Acid2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 8
GLU L  66
LEU K  45
LEU Q  45
HIS L  48
1.36A20.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J2T_C_VLBC503_2
(TUBULIN ALPHA-1B
CHAIN)		Vinblastine2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 12
LEU D  31
ASN D  10
ALA J  20
VAL D 108
GLY D 109
1.35A17.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1002_0
(ALDEHYDE
DEHYDROGENASE A)		Deoxycholic Acid2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		3 / 3
GLY H 109
ARG H 113
TYR H  27
1.68A14.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		Cefoxitin2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 12
ALA E  54
GLY E  50
ASN E  62
GLY E 121
THR E  56
1.51A18.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_A_ADNA401_2
(ADENOSINE KINASE)		Adenosine2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 4
LEU X  92
ILE X  99
GLY X  70
PHE X  68
1.69A17.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4F_A_ASRA141_0
(LYSOZYME C)		Arsanilic acid2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 6
ASN B  62
GLY B  50
PRO B  59
SER B  67
1.68A17.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_F_BEZF5023_0
(CES1 PROTEIN)		Benzoic Acid2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 6
LEU N  31
GLY N 109
LEU N  75
ILE N  38
1.44A13.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IWK_A_CUA1599_0
(NITROUS OXIDE
REDUCTASE)		Copper2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		3 / 3
CYH P  77
CYH P  90
HIS P  83
1.28A13.97
 ZN  P 998 (-2.1A)
ZN  P 998 (-2.3A)
ZN  P 998 (-3.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_D_C2FD1200_0
(GLYCINE
N-METHYLTRANSFERASE)		Levomefolic acid2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 12
LEU L  45
LEU K  45
MET R  63
THR R  49
THR K  47
1.65A20.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_0
(ADENOSYLHOMOCYSTEINA
SE)		Adenosine2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 10
GLY D  70
GLY D  94
ASP D  91
CYH D  90
ILE D  99
1.74A15.37
None
None
None
ZN  D 998 (-2.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G08_A_Z80A1187_1
(FREQUENIN 2)		Chlorpromazine2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 6
ILE H  81
TYR H  76
PHE H  89
THR A  56
1.71A18.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_B_J01B500_1
(ORF12)		Clavulanate2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 9
HIS T  80
ILE T  81
ARG T  78
ALA T  71
LYS T  93
1.74A16.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_A_PXLA1003_1
(PYRIDOXINE KINASE)		Pyridoxal2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 8
SER S  72
VAL O  21
PRO T  59
HIS T  48
1.32A18.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_B_ML1B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		Melatonin2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 11
GLY P  70
GLY P  69
ILE P  55
GLY P 109
ILE P  99
1.46A21.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVR_A_SALA203_1
(3-HYDROXYANTHRANILAT
E 3,4-DIOXYGENASE)		Salicylic acid2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 7
HIS T  80
ASP R  82
PRO R  23
VAL S  57
1.76A19.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM6_A_017A200_1
(PROTEASE)		Darunavir2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 8
GLY T  70
ALA T  71
GLY S  94
VAL R  21
0.66A22.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJ8_A_9DCA303_0
(METALLO-BETA-LACTAMA
SE TYPE 2)		Dimercaprol2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 8
HIS L  48
CYH Q  46
ASN L  62
HIS Q  48
1.71A19.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EK1_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		Camphor2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 6
TYR S  76
LEU S 112
VAL S 108
ASP S  91
1.46A16.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		Digoxin2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 12
GLN S  98
GLU S  66
PHE S  68
GLY S  70
ALA S  71
1.40A9.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IOL_A_ESTA400_1
(ESTROGENIC 17-BETA
HYDROXYSTEROID
DEHYDROGENASE)		Estradiol2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 11
SER L  72
GLY L  69
TYR K  96
HIS R  48
PHE L  68
1.66A17.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		Celecoxib2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		4 / 7
SER P  15
LEU P 112
ARG P  78
ILE P  81
1.24A13.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B9Z_A_ACRA1818_1
(ALPHA-GLUCOSIDASE,
PUTATIVE, ADG31B)		Acarbose2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 12
ILE P  81
TYR P  27
LEU P  14
ARG P  78
HIS P  83
1.75A11.04
None
None
None
None
ZN  P 998 (-3.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FJ1_A_CTCA222_0
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		Chlortetracycline2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		5 / 12
HIS W  80
PRO S  84
THR X  58
VAL X  57
LEU S 112
1.71A19.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUN_A_CCSA165_0
(LYSOZYME)		Carbocisteine2g9t ORF1A POLYPROTEIN
(SARSr-CoV)		3 / 3
ASN U  62
ALA U  61
LYS U  50
1.59A20.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VD0_B_D27B1200_0
(GLUTATHIONE-REQUIRIN
G PROSTAGLANDIN D
SYNTHASE)		Tranilast2gz8 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 10
ARG A 188
ALA A 191
TYR A  54
CYH A  44
LEU A  50
1.62A19.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		Clarithromycin2gz8 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		6 / 12
TYR A  37
VAL A  36
GLU A 178
MET A  17
VAL A  18
GLY A 149
1.75A21.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_0
(TUBULIN BETA-2B
CHAIN)		Eribulin2gz8 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		5 / 11
GLN A  74
VAL A  36
ASP A  34
THR A  93
TYR A  37
1.56A21.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAV_F_CSCF1383_2
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		Cephalosporin C2gz8 REPLICASE
POLYPROTEIN 1AB
(SARSr-CoV)		3 / 3
LEU A 208
MET A 264
MET A 235
1.72A21.03
None