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SIMILAR PATTERN OF AMINO ACIDS MAPPED TO UNIPROT ID 'Q64339'

	DrReposER ID / Desc.	Drug	Hit PDBID	Hit Macromolecule	Res. Matches	View	Interface	RMSD	Seq. Identity (%)	HETATM	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4OTW_A_DB8A1101_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-3)	Bosutinib	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	6 / 12		VAL A 146 CYH A 144 VAL A  96 GLY A 136 LEU A 135 VAL A 109	1.43A	12.54	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6NMF_G_CHDG104_0 (CYTOCHROME C OXIDASE SUBUNIT 1 CYTOCHROME C OXIDASE SUBUNIT 2 CYTOCHROME C OXIDASE SUBUNIT 6A2, MITOCHONDRIAL)	Cholic Acid	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	5 / 10		GLY A  89 MET B 209 GLY B 210 GLN B 233 THR B 232	1.56A	15.29 7.63 16.59	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5SXQ_A_NIZA808_1 (CATALASE-PEROXIDASE)	Isoniazid	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	4 / 8		GLU A 133 GLY A 136 LEU A 135 THR A  99	1.33A	7.01	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1EUP_A_ASDA452_1 (CYTOCHROME P450ERYF)	4-Androstenedione	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	5 / 8		SER A  81 ILE A  82 LEU A  80 GLU A  95 LEU A 105	1.55A	11.17	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4A3P_A_ACTA1223_0 (UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 15)	Acetic acid	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	4 / 5		ASP B  77 THR B  75 GLU A 130 LYS A 132	1.68A	21.52	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1HTT_D_HISD450_0 (HISTIDYL-TRNA SYNTHETASE)	L-Histidine	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	5 / 12		GLN A 119 GLU B 168 TYR B 274 GLY A 154 GLY B 164	1.55A	11.59	None None None AYE  A 155 ( 2.4A) None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3RR3_A_FLRA700_1 (PROSTAGLANDIN G/H SYNTHASE 2)	Flurbiprofen	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	5 / 12		TYR B 269 LEU A 152 GLY B 210 ALA B 247 SER B 246	1.11A	19.97	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3P6H_A_IBPA133_1 (FATTY ACID-BINDING PROTEIN, ADIPOCYTE)	Ibuprofen	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	4 / 7		PHE A 120 ASP A 131 VAL A  84 TYR A  94	1.55A	17.86	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3B9L_A_AZZA1010_1 (SERUM ALBUMIN)	Zidovudine	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	4 / 8		LEU A 150 TYR B 265 ARG A 153 GLY B 164	1.34A	11.42	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3SAN_A_ZMRA901_1 (NEURAMINIDASE)	Zanamivir	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	5 / 12		ARG A 127 GLU A 137 GLU A 133 ASN B 157 TYR A 138	1.78A	14.97	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5JVZ_A_FLPA601_1 (PROSTAGLANDIN G/H SYNTHASE 2)	Flurbiprofen	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	5 / 12		TYR B 269 LEU A 152 GLY B 210 ALA B 247 SER B 246	1.38A	20.79	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3N8W_A_FLPA701_1 (PROSTAGLANDIN G/H SYNTHASE 1)	Flurbiprofen	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	5 / 12		VAL C 146 LEU C 134 TYR C 138 LEU C 140 LEU C 105	1.30A	9.56	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1WOP_A_FFOA2888_0 (AMINOMETHYLTRANSFERA SE)	Levoleucovorin	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	5 / 10		LEU B 118 LEU B 121 GLU A 130 LEU B 173 MET B 170	1.61A	21.48	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2AYL_B_FLPB2701_1 (PROSTAGLANDIN G/H SYNTHASE 1)	Flurbiprofen	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	5 / 12		TYR B 269 LEU A 152 GLY B 210 ALA B 247 SER B 246	1.13A	19.64	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3B7E_A_ZMRA1001_1 (NEURAMINIDASE)	Zanamivir	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	5 / 12		ARG A 127 GLU A 137 GLU A 133 ASN B 157 TYR A 138	1.76A	11.36	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4DAN_B_2FAB301_1 (PURINE NUCLEOSIDE PHOSPHORYLASE DEOD-TYPE)	Fludarabine	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	5 / 12		ARG C  85 GLY C 126 GLU C 125 SER C 123 VAL D 203	1.67A	15.28	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4K37_B_SAMB504_0 (ANAEROBIC SULFATASE-MATURATING ENZYME)	S-Adenosylmethionine	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	5 / 11		ASN C  86 LEU C  83 VAL C 146 ILE C  82 LEU C 135	1.53A	11.29	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6CE2_B_SVRB202_1 ()	Suramin	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	4 / 8		LEU C 140 LEU C 135 LEU C  83 ARG C 112	1.21A	20.47	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BGD_B_PM6B302_1 (THIOPURINE S-METHYLTRANSFERASE)	Mercaptopurine	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	4 / 7		GLN C 100 LEU C  98 LEU C 140 LEU C 135	1.22A	16.81	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VSE_A_SAMA1505_0 (HISTONE-LYSINE N-METHYLTRANSFERASE EHMT2)	S-Adenosylmethionine	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	5 / 12		TYR A  94 ASN A  86 HIS A 149 PHE A 120 GLN A 119	1.66A	13.45	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2FK8_A_SAMA302_1 (METHOXY MYCOLIC ACID SYNTHASE 4)	S-Adenosylmethionine	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	3 / 3		SER A  81 THR A 104 GLN A 100	1.05A	14.92	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ASD_A_BAXA1500_2 (VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2)	Sorafenib	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	4 / 6		ILE A  93 VAL A  84 LEU A 122 ILE A  82	1.15A	13.66	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4MJ8_B_SPMB201_1 (SPERMIDINE N1-ACETYLTRANSFERASE)	Spermine	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	4 / 8		GLU C 137 TYR C 138 GLU C 130 ARG C 127	1.77A	15.61	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ND4_B_TA1B601_1 (TUBULIN BETA-2B CHAIN)	Paclitaxel	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	5 / 12		LEU D 200 ALA D 205 SER D 240 ARG C 127 LEU D 174	1.68A	22.00	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2Z9W_A_PXLA1197_1 (ASPARTATE AMINOTRANSFERASE)	Pyridoxal	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	5 / 11		LEU A 105 TYR A  94 VAL A  84 SER A  91 ASN A  86	1.72A	12.17	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1CQP_B_803B311_1 (ANTIGEN CD11A (P180))	Lovastatin	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	5 / 7		VAL C 146 LEU C 135 VAL C  96 TYR C  94 LEU C 122	1.60A	17.76	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6EU9_B_REAB601_1 (RETINOIC ACID RECEPTOR)	Tretinoin	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	5 / 10		VAL A 102 LEU A 105 GLY A 136 GLY A 126 ARG A 127	1.45A	16.74	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FEU_D_KAND301_1 (AMINOGLYCOSIDE 3'-PHOSPHOTRANSFERAS E APHA1-IAB)	Kanamycin	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	4 / 8		ASP C 131 ASP C 118 GLU D 162 GLU C 117	1.50A	16.06	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5DV4_A_NMYA601_2 (CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 6-LIKE)	Framycetin	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	3 / 3		GLU B 162 TRP A 121 ASN B 157	1.58A	21.29	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4OR0_B_NPSB603_1 (SERUM ALBUMIN)	Naproxen	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	5 / 11		ARG C 112 LEU C  83 VAL C  96 SER C  81 LEU C  80	1.72A	8.92	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FGZ_A_CQAA302_0 (PHOSPHOETHANOLAMINE N-METHYLTRANSFERASE)	Amodiaquine	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	4 / 7		GLU C 125 TYR C 138 ARG C 127 GLY C 136	1.43A	15.38	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XL6_B_SPMB3001_1 (INWARD RECTIFIER POTASSIUM CHANNEL)	Spermine	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	4 / 5		ALA D 250 TYR D 265 ALA D 247 GLN C 119	1.59A	20.76	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2P16_A_GG2A298_1 (COAGULATION FACTOR X (EC 3.4.21.6) (STUART FACTOR) (STUART-PROWER FACTOR))	Apixaban	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	5 / 12		ASP D 165 SER D 116 VAL D 117 GLY C 154 GLY D 164	1.65A	22.05	None None None AYE  C 155 (-2.3A) None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3TAJ_A_NBOA700_1 (LACTOTRANSFERRIN)	Nabumetone	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	4 / 7		GLY A  89 ASN A  86 GLY B 210 THR B 211	1.07A	11.59	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3TJ7_A_ACTA604_0 (GBAA_1210 PROTEIN)	Acetic acid	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	4 / 6		GLY A 126 HIS A 149 SER A 123 THR B 171	1.28A	18.52	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MAA_D_DMED999_1 (ACETYLCHOLINESTERASE)	Decamethonium	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	4 / 8		GLY A 126 SER A 123 TYR B 208 HIS A 149	1.43A	8.78	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3RR3_C_FLRC700_1 (PROSTAGLANDIN G/H SYNTHASE 2)	Flurbiprofen	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	5 / 12		TYR B 269 LEU A 152 GLY B 210 ALA B 247 SER B 246	1.10A	19.97	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3HCP_B_CHDB4_0 (FERROCHELATASE, MITOCHONDRIAL)	Cholic Acid	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	3 / 3		GLY D 267 PRO D 249 LEU C 152	1.01A	20.55	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4DF3_A_SAMA301_1 (FIBRILLARIN-LIKE RRNA/TRNA 2'-O-METHYLTRANSFERA SE)	S-Adenosylmethionine	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	3 / 3		TYR B 208 THR B 211 GLU A  87	1.58A	18.89	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3RR3_A_FLRA700_1 (PROSTAGLANDIN G/H SYNTHASE 2)	Flurbiprofen	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	5 / 12		VAL C 146 VAL C  96 TYR C  94 LEU C 105 LEU C 140	1.33A	9.54	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ZZ1_C_SHHC2652_1 (HISTONE DEACETYLASE-LIKE AMIDOHYDROLASE)	Vorinostat	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	5 / 12		LEU B 153 ASP B  38 GLY B 161 GLY A 154 TYR B 113	1.60A	21.58	None None None AYE  A 155 ( 2.4A) None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4MI4_B_SPMB201_1 (SPERMIDINE N1-ACETYLTRANSFERASE)	Spermine	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	4 / 7		GLU C 137 TYR C 138 GLU C 130 ARG C 127	1.77A	15.74	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5JHN_B_SAMB1205_0 (HISTONE-LYSINE N-METHYLTRANSFERASE EHMT2)	S-Adenosylmethionine	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	5 / 12		TYR A  94 ASN A  86 HIS A 149 PHE A 120 GLN A 119	1.67A	13.14	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FOX_C_D16C301_1 (THYMIDYLATE SYNTHASE)	Raltitrexed	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	5 / 11		SER A 110 GLU A 113 LEU A  83 LEU A 122 PHE A 120	1.66A	13.79	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FEW_B_KANB301_1 (AMINOGLYCOSIDE 3'-PHOSPHOTRANSFERAS E APHA1-IAB)	Kanamycin	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	4 / 7		ASP C 131 ASP C 118 GLU D 162 GLU C 117	1.43A	16.06	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1HTT_B_HISB450_0 (HISTIDYL-TRNA SYNTHETASE)	L-Histidine	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	5 / 12		GLN A 119 GLU B 168 TYR B 274 GLY A 154 GLY B 164	1.52A	11.59	None None None AYE  A 155 ( 2.4A) None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2OIQ_A_STIA1001_2 (PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC)	Imatinib	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	4 / 5		LEU C 152 VAL C 102 LEU C 105 ARG C 127	1.47A	16.96	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2NMZ_B_ROCB401_2 (PROTEASE)	Saquinavir	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	3 / 3		ARG C 153 VAL D 117 THR D 169	1.26A	18.95	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3HUO_B_PNNB301_0 (CTX-M-9 EXTENDED-SPECTRUM BETA-LACTAMASE)	Benzylpenicillin	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	5 / 12		GLY B 272 ASN B 110 GLY A 154 ASP B 109 ARG A 151	1.68A	21.92	None AYE  A 155 ( 4.2A) AYE  A 155 ( 2.4A) None None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V0M_C_KLNC1498_1 (CYTOCHROME P450 3A4)	Ketoconazole	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	5 / 12		PHE C 124 LEU C  80 THR C 104 MET C 129 GLU C 137	1.65A	10.43	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4GKH_F_KANF301_1 (AMINOGLYCOSIDE 3'-PHOSPHOTRANSFERAS E APHA1-IAB)	Kanamycin	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	4 / 8		ASP C 131 ASP C 118 GLU D 162 GLU C 117	1.56A	16.06	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5Y7P_G_CHDG401_0 (BILE SALT HYDROLASE)	Cholic Acid	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	5 / 10		TYR B 155 LEU B 133 ALA B  69 LEU B  81 GLU A 133	1.57A	22.50	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3HGX_A_SALA102_1 (SALICYLATE BIOSYNTHESIS PROTEIN PCHB)	Salicylic acid	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	4 / 7		VAL C  84 ILE C  93 TYR C  94 ILE C  82	1.56A	20.79	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4V04_B_0LIB1771_1 (FIBROBLAST GROWTH FACTOR RECEPTOR 1 (FMS-RELATED TYROSINE KINASE 2, PFEIFFER SYNDROME), ISOFORM CRA_B)	Ponatinib	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	5 / 10		LEU A 152 TYR B 265 ARG B 141 ILE B 286 LEU B 121	1.66A	12.62	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1J96_B_TESB904_1 (3ALPHA-HYDROXYSTEROI D DEHYDROGENASE TYPE 3)	Testosterone	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	5 / 7		VAL C 146 ILE C 147 HIS D 172 GLU D 168 TRP C 121	1.72A	14.72	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3I5U_B_SAMB401_0 (O-METHYLTRANSFERASE)	S-Adenosylmethionine	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	5 / 12		GLY A 154 GLY B 164 LEU B 114 SER B 115 ASP B 303	1.51A	14.05	AYE  A 155 ( 2.4A) None None None None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5JIN_B_SAMB1205_0 (HISTONE-LYSINE N-METHYLTRANSFERASE EHMT2)	S-Adenosylmethionine	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	5 / 12		TYR A  94 ASN A  86 HIS A 149 PHE A 120 GLN A 119	1.62A	13.14	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3REM_A_SALA301_1 (SALICYLATE BIOSYNTHESIS PROTEIN PCHB)	Salicylic acid	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	4 / 8		ARG C  85 VAL C 146 ILE C  82 GLN C 143	1.53A	23.30	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3HUO_A_PNNA302_0 (CTX-M-9 EXTENDED-SPECTRUM BETA-LACTAMASE)	Benzylpenicillin	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	4 / 6		THR B 302 LEU A 152 GLY A 154 PRO B 249	0.93A	21.92	None None AYE  A 155 ( 2.4A) None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2OIQ_A_STIA1001_2 (PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC)	Imatinib	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	4 / 5		LEU B 217 VAL A  84 LEU A 122 MET B 207	1.20A	21.68	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5JVZ_B_FLPB601_1 (PROSTAGLANDIN G/H SYNTHASE 2)	Flurbiprofen	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	5 / 12		TYR B 269 LEU A 152 GLY B 210 ALA B 247 SER B 246	1.41A	20.79	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4GKI_A_KANA301_1 (AMINOGLYCOSIDE 3'-PHOSPHOTRANSFERAS E APHA1-IAB)	Kanamycin	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	4 / 8		ASP C 131 ASP C 118 GLU D 162 GLU C 117	1.55A	16.06	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4MGH_A_ACTA1320_0 (PHOSPHORIBOSYLFORMYL GLYCINAMIDINE SYNTHASE)	Acetic acid	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	4 / 5		VAL C 146 LEU C 105 ILE C  82 LEU C  83	1.20A	5.05	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1SDV_B_MK1B902_1 (PROTEASE RETROPEPSIN)	Indinavir	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	5 / 10		LEU A  83 GLY A 136 GLY A 139 PRO A 142 ILE A  82	1.49A	18.95	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3THR_D_C2FD1200_0 (GLYCINE N-METHYLTRANSFERASE)	Levomefolic acid	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	5 / 12		LEU A 105 LEU A 122 HIS A 149 TYR A  94 THR A 145	1.73A	13.99	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5T8S_B_SAMB402_1 (S-ADENOSYLMETHIONINE SYNTHASE)	S-Adenosylmethionine	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	4 / 8		ASP A 131 LYS B 158 SER B 156 THR B 171	1.23A	12.34	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2XCT_X_CPFX1020_1 (DNA GYRASE SUBUNIT B, DNA GYRASE SUBUNIT A)	Ciprofloxacin	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	4 / 4		ARG A 151 GLY B 164 GLU B 162 SER B 246	1.78A	7.46	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2OPX_A_DXCA1002_0 (ALDEHYDE DEHYDROGENASE A)	Deoxycholic Acid	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	3 / 3		GLY D 164 ARG C 153 TYR D 113	1.54A	19.96	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VSC_A_SAMA1505_0 (HISTONE-LYSINE N-METHYLTRANSFERASE EHMT2)	S-Adenosylmethionine	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	5 / 12		TYR A  94 ASN A  86 HIS A 149 PHE A 120 GLN A 119	1.65A	13.45	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1CQP_A_803A311_1 (ANTIGEN CD11A (P180))	Lovastatin	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	5 / 10		LEU A 135 VAL A  96 LEU A 122 LYS A 148 VAL A 146	1.49A	17.76	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2OPX_A_DXCA1001_0 (ALDEHYDE DEHYDROGENASE A)	Deoxycholic Acid	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	4 / 7		LEU B 151 PHE B  80 ASN B 157 GLU A 130	1.29A	19.96	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5V9I_A_SAMA1505_0 (HISTONE-LYSINE N-METHYLTRANSFERASE EHMT2)	S-Adenosylmethionine	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	5 / 12		TYR A  94 ASN A  86 HIS A 149 PHE A 120 GLN A 119	1.67A	14.04	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5X7P_A_ACRA1481_1 (GLYCOSIDE HYDROLASE FAMILY 31 ALPHA-GLUCOSIDASE)	Acarbose	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	4 / 6		SER D 156 HIS D 172 ARG C 151 GLU D 168	1.50A	13.95	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5BOJ_A_4TXA201_1 (TRANSTHYRETIN)	Gemfibrozil	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	4 / 6		LEU C 105 LEU C 122 SER C 123 THR C 145	1.32A	18.90	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4BKJ_B_STIB1000_2 (EPITHELIAL DISCOIDIN DOMAIN-CONTAINING RECEPTOR 1)	Imatinib	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	4 / 5		LEU C 122 TYR D 208 MET D 209 ARG C 112	1.55A	13.06	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5E3I_A_HISA502_0 (HISTIDINE--TRNA LIGASE)	L-Histidine	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	5 / 12		GLN A 119 GLU B 168 TYR B 274 GLY A 154 GLY B 164	1.62A	11.11	None None None AYE  A 155 ( 2.4A) None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ZOS_B_0LIB1000_2 (EPITHELIAL DISCOIDIN DOMAIN-CONTAINING RECEPTOR 1)	Ponatinib	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	5 / 9		LEU C 152 LEU D 121 MET D 244 TYR D 265 ILE D 152	1.66A	13.06	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2YA7_C_ZMRC1776_2 (NEURAMINIDASE A)	Zanamivir	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	4 / 6		ARG A 151 ILE A 147 GLU A 113 TYR A  94	1.73A	8.92	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FEV_B_KANB301_1 (AMINOGLYCOSIDE 3'-PHOSPHOTRANSFERAS E APHA1-IAB)	Kanamycin	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	4 / 7		ASP C 131 ASP C 118 GLU D 162 GLU C 117	1.45A	16.06	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4KCN_A_MTLA804_0 (NITRIC OXIDE SYNTHASE, BRAIN)	Mannitol	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	4 / 6		GLU C 133 ASP D  77 ASP D  41 ARG D  83	1.71A	12.35	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3RQW_I_ACHI323_0 (ELIC PENTAMERIC LIGAND GATED ION CHANNEL FROM ERWINIA CHRYSANTHEMI)	Acetylcholine	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	4 / 8		TYR C  94 GLU C 113 LEU C 122 PHE C 120	1.32A	13.12	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5TE0_A_XINA401_1 (AP2-ASSOCIATED PROTEIN KINASE 1)	Nintedanib	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	5 / 12		ALA B  87 LEU B  37 ALA B  40 GLU A 130 GLY B 161	1.17A	21.60	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1EKJ_A_ACTA3001_0 (BETA-CARBONIC ANHYDRASE)	Acetic acid	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	4 / 8		CYH D 112 GLY C 154 GLY D 272 TYR D 265	1.43A	23.55	AYE  C 155 (-1.6A) AYE  C 155 (-2.3A) AYE  C 155 ( 4.7A) None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2BR4_D_SAMD301_1 (CEPHALOSPORIN HYDROXYLASE CMCI)	S-Adenosylmethionine	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	3 / 3		LYS A 132 ASP B  62 ASP B  77	1.63A	14.91	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3S8P_A_SAMA500_1 (HISTONE-LYSINE N-METHYLTRANSFERASE SUV420H1)	S-Adenosylmethionine	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	3 / 3		HIS A 149 SER B 156 GLU B 168	1.51A	15.73	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1NX9_A_AICA5001_1 (ALPHA-AMINO ACID ESTER HYDROLASE)	Ampicillin	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	4 / 8		GLU B 204 GLN B 233 HIS A 149 SER A 123	1.25A	16.95	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3HUO_B_PNNB301_0 (CTX-M-9 EXTENDED-SPECTRUM BETA-LACTAMASE)	Benzylpenicillin	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	5 / 12		GLY A 154 ASN B 110 GLY B 164 GLY B 161 ASP B 109	1.54A	15.21	AYE  A 155 ( 2.4A) AYE  A 155 ( 4.2A) None None None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5V0V_A_8QPA612_1 (SERUM ALBUMIN)	Etodolac	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	5 / 12		GLU B 204 LEU B 217 LEU B 186 ILE B 223 GLU A  87	1.47A	19.19	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5TWJ_D_SAMD201_0 (RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE H)	S-Adenosylmethionine	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	6 / 11		LEU B 174 GLY A 126 LEU B 179 SER B 181 THR B 201 VAL B 206	1.62A	19.63	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1PK7_B_ADNB1246_1 (PURINE NUCLEOSIDE PHOSPHORYLASE)	Adenosine	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	4 / 8		GLY D 202 VAL D 203 GLU D 204 GLU C 125	1.25A	21.86	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4TWD_G_377G401_1 (CYS-LOOP LIGAND-GATED ION CHANNEL)	Memantine	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	4 / 6		ARG A  85 GLU A 113 TYR A  94 LEU A  83	1.68A	13.42	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5X1F_G_CHDG104_0 (CYTOCHROME C OXIDASE SUBUNIT 1 CYTOCHROME C OXIDASE SUBUNIT 2 CYTOCHROME C OXIDASE SUBUNIT 6A2, MITOCHONDRIAL)	Cholic Acid	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	5 / 11		GLY A  89 MET B 209 GLY B 210 GLN B 233 THR B 232	1.67A	15.29 7.63 16.59	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2Y7H_B_SAMB530_1 (TYPE I RESTRICTION ENZYME ECOKI M PROTEIN)	S-Adenosylmethionine	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	3 / 3		TYR C 138 GLU C 130 THR D  75	1.64A	9.51	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1HK1_A_T44A3004_1 (SERUM ALBUMIN)	Levothyroxine	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	4 / 6		PHE C 120 GLU C 117 LEU C 105 VAL C 146	1.41A	11.42	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2F9W_A_PAUA6001_0 (PANTOTHENATE KINASE)	Pantothenic acid	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	5 / 11		GLY C  89 ARG C  85 THR C 145 ILE C 147 ARG C  88	1.64A	17.43	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3SI7_D_ACTD4_0 (CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR)	Acetic acid	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	4 / 5		LEU A  80 LEU A 140 GLY A 139 GLY A 136	0.95A	14.18	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6GNG_B_QPSB601_2 (-)	Acarbose	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	5 / 12		GLY B 164 GLY A 154 LEU B 163 GLY B  39 ASN B 111	1.59A	18.60	None AYE  A 155 ( 2.4A) AYE  A 155 ( 4.3A) None None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2QEB_A_HSMA145_1 (D7R4 PROTEIN)	Histamine	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	4 / 7		ARG A 151 TYR B 113 TYR B 274 GLU B 168	1.56A	20.41	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2NV4_A_ACTA148_0 (UPF0066 PROTEIN AF_0241)	Acetic acid	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	3 / 3		VAL C 102 GLU C 130 GLU C 133	1.13A	19.71	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2F9W_A_PAUA6002_0 (PANTOTHENATE KINASE)	Pantothenic acid	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	4 / 8		GLY C  89 ARG C  85 THR C 145 ILE C 147	1.17A	17.43	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XVA_A_SAMA293_0 (GLYCINE N-METHYLTRANSFERASE)	S-Adenosylmethionine	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	5 / 12		ASP B 165 SER B 246 GLY A  89 ILE B 223 TYR B 208	1.60A	24.27	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2CDQ_B_SAMB1500_0 (ASPARTOKINASE)	S-Adenosylmethionine	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	4 / 7		ASP D 165 TRP C 121 LEU C 150 GLU C  87	1.57A	19.92	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ETR_H_MITH1_1 (EPSILON-THROMBIN)	Argatroban	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	5 / 12		ASP D 165 SER D 116 VAL D 117 GLY C 154 GLY D 164	1.73A	22.62	None None None AYE  C 155 (-2.3A) None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4K37_A_SAMA504_0 (ANAEROBIC SULFATASE-MATURATING ENZYME)	S-Adenosylmethionine	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	5 / 11		SER A  91 LEU A  83 VAL A 146 ILE A  82 LEU A 135	1.70A	11.29	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4UHX_A_RTZA3009_1 (ALDEHYDE OXIDASE)	Thioridazine	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	4 / 8		HIS D 172 GLU D 168 SER C 123 ARG C 127	1.55A	13.83	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3N62_A_MTLA870_0 (NITRIC OXIDE SYNTHASE)	Mannitol	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	4 / 8		SER A  91 ARG A  85 GLN A 143 ASN A  92	1.55A	12.35	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3KK6_A_CELA701_1 (PROSTAGLANDIN G/H SYNTHASE 1)	Celecoxib	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	5 / 12		TYR B 269 LEU A 152 GLY B 210 ALA B 247 SER B 246	1.28A	19.64	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5TTF_B_SAMB1505_0 (HISTONE-LYSINE N-METHYLTRANSFERASE EHMT2)	S-Adenosylmethionine	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	5 / 12		TYR A  94 ASN A  86 HIS A 149 PHE A 120 GLN A 119	1.70A	14.04	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2IDK_B_C2FB1420_0 (GLYCINE N-METHYLTRANSFERASE)	Levomefolic acid	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	5 / 10		LEU A 105 LEU A 122 HIS A 149 TYR A  94 THR A 145	1.79A	14.04	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3EM3_B_478B200_2 (PROTEASE)	Amprenavir	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	5 / 10		LEU C  83 VAL C  96 GLY C 139 PRO C 142 ILE C  82	1.47A	18.95	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3B6R_B_CRNB603_1 (CREATINE KINASE B-TYPE)	Creatine	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	4 / 6		THR A 145 VAL A 146 GLU B 204 SER A 123	1.46A	14.29	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ZVG_A_SAMA401_1 (389AA LONG HYPOTHETICAL NUCLEOLAR PROTEIN)	S-Adenosylmethionine	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	3 / 3		ASP C 118 ARG C 151 ASP C 103	1.73A	13.17	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5UUN_A_ACTA303_0 (GLUTATHIONE S-TRANSFERASE-LIKE PROTEIN)	Acetic acid	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	3 / 3		GLU C  95 TYR C  94 ARG C 112	1.34A	14.93	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4L8F_B_MTXB301_1 (GAMMA-GLUTAMYL HYDROLASE)	Methotrexate	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	5 / 11		GLY D 164 GLY C 154 GLY D 272 LEU D 163 GLN D 270	0.73A	23.01	None AYE  C 155 (-2.3A) AYE  C 155 ( 4.7A) AYE  C 155 ( 4.4A) None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3KP3_B_AICB2002_1 (TRANSCRIPTIONAL REGULATOR TCAR)	Ampicillin	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	3 / 3		ALA B  40 ARG B  83 LYS A 132	1.64A	18.32	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5T0K_A_SAMA1304_0 (HISTONE-LYSINE N-METHYLTRANSFERASE EHMT2)	S-Adenosylmethionine	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	5 / 12		TYR A  94 ASN A  86 HIS A 149 PHE A 120 GLN A 119	1.67A	13.88	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3NDT_A_ROCA101_2 (PROTEASE)	Saquinavir	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	3 / 3		ARG C 153 VAL D 117 THR D 169	1.11A	18.75	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XKK_A_FMMA91_1 (EPIDERMAL GROWTH FACTOR RECEPTOR)	Lapatinib	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	5 / 12		ALA B 150 LEU B 163 ARG A 153 LEU B 114 ASP B 109	1.35A	20.83	None AYE  A 155 ( 4.3A) None None None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2VDV_F_SAMF1287_0 (TRNA (GUANINE-N(7)-)-METH YLTRANSFERASE)	S-Adenosylmethionine	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	5 / 11		GLU D 162 ALA D  40 ASP C 131 THR D 169 GLU D 168	1.45A	20.68	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4V04_B_0LIB1771_2 (FIBROBLAST GROWTH FACTOR RECEPTOR 1 (FMS-RELATED TYROSINE KINASE 2, PFEIFFER SYNDROME), ISOFORM CRA_B)	Ponatinib	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	5 / 12		ALA B  40 GLU A 130 ALA B  87 LEU B 173 ALA B 154	1.47A	23.75	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5TUY_A_SAMA1505_0 (HISTONE-LYSINE N-METHYLTRANSFERASE EHMT2)	S-Adenosylmethionine	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	5 / 12		TYR A  94 ASN A  86 HIS A 149 PHE A 120 GLN A 119	1.67A	12.92	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5IKR_B_ID8B602_2 (PROSTAGLANDIN G/H SYNTHASE 2)	Mefenamic acid	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	3 / 3		SER B 156 LEU A 122 MET A 129	1.66A	19.64	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3QEO_B_LLTB261_1 (DEOXYCYTIDINE KINASE)	Telbivudine	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	4 / 7		GLU A  87 LEU A 152 TYR B 274 LEU B 212	1.45A	16.49	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1SQF_A_SAMA430_0 (SUN PROTEIN)	S-Adenosylmethionine	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	5 / 12		CYH B 112 GLY B 288 ASP B 109 GLY B 164 ARG A 153	1.49A	22.37	AYE  A 155 ( 1.6A) None None None None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1NP1_A_HSMA303_1 (NITROPHORIN 1)	Histamine	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	4 / 5		GLU A  95 LEU A  98 LEU A  80 LEU A 135	1.74A	15.76	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5UUN_A_ACTA310_0 (GLUTATHIONE S-TRANSFERASE-LIKE PROTEIN)	Acetic acid	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	3 / 3		GLU A 117 HIS A 116 ARG A 153	1.40A	14.93	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3N8Z_A_FLPA701_1 (PROSTAGLANDIN G/H SYNTHASE 1)	Flurbiprofen	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	5 / 12		TYR B 269 LEU A 152 GLY B 210 ALA B 247 SER B 246	1.19A	19.64	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BXN_B_SAMB901_0 (DIPHTHAMIDE BIOSYNTHESIS ENZYME DPH2)	S-Adenosylmethionine	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	5 / 12		PHE A 120 LEU A 152 GLY B 164 GLN A 119 ASP A 131	1.78A	12.58	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FSL_A_NIOA145_1 (LEGHEMOGLOBIN A)	Niacin	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	4 / 8		PHE C 120 HIS C 149 LEU C 122 VAL C 109	1.12A	18.88	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3AX7_B_SALB1336_1 (XANTHINE DEHYDROGENASE/OXIDAS E)	Salicylic acid	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	5 / 9		GLU C 113 ARG C  85 THR C 145 VAL C 146 LEU C 122	1.66A	5.23	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4MS4_A_2C0A501_1 (GAMMA-AMINOBUTYRIC ACID TYPE B RECEPTOR SUBUNIT 1)	Baclofen	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	4 / 8		SER C  91 HIS C  90 TYR C  94 ILE C  93	1.49A	11.70	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4XR4_B_AG2B511_1 (HOMOSPERMIDINE SYNTHASE)	Agmatine	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	3 / 3		VAL C 102 PHE C 120 ARG C 151	1.76A	12.98	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VCE_A_RITA602_2 (CYTOCHROME P450 3A4)	Ritonavir	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	4 / 6		ARG C  88 ARG C  85 ILE C  82 THR C 145	1.73A	10.39	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4L1X_B_STRB402_1 (ALDO-KETO REDUCTASE FAMILY 1 MEMBER C2)	Progesterone	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	5 / 9		VAL C 146 ILE C 147 HIS D 172 GLU D 168 TRP C 121	1.79A	14.98	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3EKP_B_478B200_2 (PROTEASE)	Amprenavir	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	5 / 10		LEU C  83 VAL C  96 GLY C 139 PRO C 142 ILE C  82	1.46A	22.22	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5SYJ_A_NIZA809_1 (CATALASE-PEROXIDASE)	Isoniazid	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	4 / 8		GLU A 133 GLY A 136 LEU A 135 THR A  99	1.30A	7.01	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1GTI_D_CCSD47_0 (GLUTATHIONE S-TRANSFERASE)	Carbocisteine	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	4 / 7		THR C 101 GLY C 136 LEU C 140 TYR C 138	1.45A	18.10	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2NNK_A_ROCA401_2 (PROTEASE)	Saquinavir	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	3 / 3		ARG C 153 VAL D 117 THR D 169	1.24A	18.95	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ZVG_A_SAMA401_1 (389AA LONG HYPOTHETICAL NUCLEOLAR PROTEIN)	S-Adenosylmethionine	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	3 / 3		ASP D  77 ARG D  83 ASP C 131	1.47A	22.42	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3UNI_A_SALA1344_1 (XANTHINE DEHYDROGENASE/OXIDAS E)	Salicylic acid	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	5 / 7		GLU A 113 ARG A  85 THR A 145 VAL A 146 LEU A 122	1.78A	5.23	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1YA3_B_STRB2001_2 (MINERALOCORTICOID RECEPTOR)	Progesterone	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	3 / 3		LEU C 152 LEU C 150 MET D 209	1.35A	16.88	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3CKZ_A_ZMRA469_1 (NEURAMINIDASE)	Zanamivir	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	5 / 12		ARG A 127 GLU A 137 GLU A 133 ASN B 157 TYR A 138	1.77A	12.36	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2BR4_D_SAMD301_0 (CEPHALOSPORIN HYDROXYLASE CMCI)	S-Adenosylmethionine	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	5 / 12		LEU B 114 GLY A 154 SER B 116 ARG A 153 CYH B 271	1.40A	18.30	None AYE  A 155 ( 2.4A) None None None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FEW_D_KAND301_1 (AMINOGLYCOSIDE 3'-PHOSPHOTRANSFERAS E APHA1-IAB)	Kanamycin	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	4 / 8		ASP C 131 ASP C 118 GLU D 162 GLU C 117	1.56A	16.06	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4K39_A_SAMA504_0 (ANAEROBIC SULFATASE-MATURATING ENZYME)	S-Adenosylmethionine	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	5 / 12		ASN C  86 LEU C  83 VAL C 146 ILE C  82 LEU C 135	1.51A	11.29	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4K36_B_SAMB504_0 (ANAEROBIC SULFATASE-MATURATING ENZYME)	S-Adenosylmethionine	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	5 / 12		ASN C  86 LEU C  83 VAL C 146 ILE C  82 LEU C 135	1.47A	12.46	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FEX_B_KANB301_1 (AMINOGLYCOSIDE 3'-PHOSPHOTRANSFERAS E APHA1-IAB)	Kanamycin	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	4 / 7		ASP C 131 ASP C 118 GLU D 162 GLU C 117	1.54A	16.06	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2R5P_B_MK1B902_1 (PROTEASE)	Indinavir	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	6 / 12		LEU A  83 VAL A  96 GLY A 136 GLY A 139 PRO A 142 ILE A  82	1.54A	22.00	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4GKH_K_KANK301_1 (AMINOGLYCOSIDE 3'-PHOSPHOTRANSFERAS E APHA1-IAB)	Kanamycin	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	4 / 8		ASP C 131 ASP C 118 GLU D 162 GLU C 117	1.58A	16.06	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5D4U_C_SAMC301_0 (UNCHARACTERIZED PROTEIN MJ0489)	S-Adenosylmethionine	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	6 / 12		LEU A 152 HIS B 276 LEU B 118 GLY B 288 ILE B 105 GLY B 272	1.61A	15.07	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3TGV_B_BEZB160_0 (HEME-BINDING PROTEIN HUTZ)	Benzoic Acid	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	4 / 4		LEU A 135 GLY A 136 LEU A 134 GLU A 133	1.54A	20.13	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1RG9_A_SAMA385_0 (S-ADENOSYLMETHIONINE SYNTHETASE)	S-Adenosylmethionine	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	4 / 8		ASP A 131 LYS B 158 SER B 156 THR B 171	1.26A	12.57	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3HS4_A_AZMA702_1 (CARBONIC ANHYDRASE 2)	Acetazolamide	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	4 / 7		VAL C  84 TYR C  94 LYS C 106 GLU C 117	1.49A	14.96	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4I41_A_MIXA500_2 (SERINE/THREONINE-PRO TEIN KINASE PIM-1)	Mitoxantrone	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	4 / 4		LEU A 140 LEU A 122 GLN A 143 GLU A  95	1.53A	13.26	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2PIW_A_T3A933_1 (ANDROGEN RECEPTOR)	Liothyronine	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	5 / 10		GLY A 154 ASN B 263 TYR B 265 GLU B 264 ARG B 285	1.55A	14.46	AYE  A 155 ( 2.4A) None None None None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2IDK_A_C2FA1410_0 (GLYCINE N-METHYLTRANSFERASE)	Levomefolic acid	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	5 / 11		TYR A  94 THR A 145 LEU A 122 HIS A 149 LEU A 105	1.68A	14.04	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5IKT_A_TLFA601_0 (PROSTAGLANDIN G/H SYNTHASE 2)	Tolfenamic Acid	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	5 / 12		VAL A 102 VAL A 146 SER A 123 GLY A 139 LEU A 135	1.34A	10.79	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FEU_F_KANF301_1 (AMINOGLYCOSIDE 3'-PHOSPHOTRANSFERAS E APHA1-IAB)	Kanamycin	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	4 / 8		ASP C 131 ASP C 118 GLU D 162 GLU C 117	1.55A	16.06	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3K4V_B_ROCB201_2 (HIV-1 PROTEASE)	Saquinavir	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	3 / 3		ARG C 153 VAL D 117 THR D 169	1.20A	18.75	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1V8B_A_ADNA502_2 (ADENOSYLHOMOCYSTEINA SE)	Adenosine	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	3 / 3		GLU A 130 GLU B 168 LEU B 153	1.31A	10.19	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FOX_A_D16A301_1 (THYMIDYLATE SYNTHASE)	Raltitrexed	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	5 / 12		SER A 110 GLU A 113 LEU A  83 LEU A 122 PHE A 120	1.61A	13.79	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BC9_A_ETSA302_2 (CARBONIC ANHYDRASE 2)	Dorzolamide	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	4 / 5		HIS D 176 GLU C 137 LEU C 122 VAL C 102	1.73A	20.41	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3PGH_A_FLPA701_1 (CYCLOOXYGENASE-2)	Flurbiprofen	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	5 / 12		TYR B 269 LEU A 152 GLY B 210 ALA B 247 SER B 246	1.23A	19.04	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3G8I_A_RO7A1_1 (PEROXISOME PROLIFERATOR-ACTIVAT ED RECEPTOR ALPHA)	Aleglitazar	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	5 / 12		VAL C 115 TYR D 265 MET D 209 VAL D 166 TYR D 274	1.76A	17.26	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5JH7_B_6K9B503_0 (TUBULIN BETA-2B CHAIN)	Eribulin	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	5 / 11		GLN A 119 VAL A 109 SER A 110 TYR A  94 LEU A 122	1.70A	10.55	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2OAX_F_SNLF6001_2 (MINERALOCORTICOID RECEPTOR)	Spironolactone	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	4 / 5		LEU A 135 LEU A 140 LEU A  83 MET A 129	1.27A	16.88	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4DJE_B_C2FB302_0 (5-METHYLTETRAHYDROFO LATE CORRINOID/IRON SULFUR PROTEIN METHYLTRANSFERASE)	Levomefolic acid	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	5 / 12		GLU B 168 ASP B 303 ASN B 263 GLY B 164 GLN A 119	1.59A	20.19	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MZ9_D_VDYD1001_4 (CARTILAGE OLIGOMERIC MATRIX PROTEIN)	Calcidiol	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	4 / 4		THR C  99 LEU C 135 VAL C 102 LEU C 122	1.40A	22.37	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5OM2_B_DXTB501_1 (ALPHA-1-ANTICHYMOTRY PSIN)	Doxycycline	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	5 / 9		LEU A 105 ASP A 131 VAL A  84 HIS A 149 ILE A  82	1.46A	11.49 20.78	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5CDQ_E_MFXE2101_1 (DNA GYRASE SUBUNIT A DNA GYRASE SUBUNIT B,DNA GYRASE SUBUNIT B)	Moxifloxacin	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	4 / 5		SER B 246 GLY A 126 GLU A 125 ARG B 167	1.76A	22.35 18.27	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1HTT_C_HISC450_0 (HISTIDYL-TRNA SYNTHETASE)	L-Histidine	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	5 / 12		GLN A 119 GLU B 168 TYR B 274 GLY A 154 GLY B 164	1.53A	11.59	None None None AYE  A 155 ( 2.4A) None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6MN4_A_AM2A301_0 (AMINOGLYCOSIDE N(3)-ACETYLTRANSFERA SE, AAC(3)-IVA)	Apramycin	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	4 / 8		TRP A 121 ASP A 118 HIS B 172 ASP A 131	1.47A	17.00	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5Z12_B_9CRB501_2 (RETINOIC ACID RECEPTOR RXR-ALPHA)	Alitretinoin	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	3 / 3		GLN A 114 ILE A 147 HIS A 149	0.83A	17.41	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2J9D_A_ACTA1117_0 (HYPOTHETICAL NITROGEN REGULATORY PII-LIKE PROTEIN MJ0059)	Acetic acid	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	3 / 3		ASP B 165 ARG A 153 ARG A 151	1.62A	16.35	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4K36_A_SAMA504_0 (ANAEROBIC SULFATASE-MATURATING ENZYME)	S-Adenosylmethionine	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	5 / 12		ASN C  86 LEU C  83 VAL C 146 ILE C  82 LEU C 135	1.48A	12.46	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4KLR_A_CHDA504_0 (FERROCHELATASE, MITOCHONDRIAL)	Cholic Acid	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	4 / 7		LEU D 153 ARG C 153 ARG C 151 SER D  79	1.54A	20.57	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1CQE_A_FLPA1650_1 (PROTEIN (PROSTAGLANDIN H2 SYNTHASE-1))	Flurbiprofen	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	5 / 12		TYR B 269 LEU A 152 GLY B 210 ALA B 247 SER B 246	1.23A	19.25	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1U18_B_HSMB402_1 (NITROPHORIN 1)	Histamine	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	4 / 5		ASP A 131 GLU A 117 THR A 101 LEU A 105	1.53A	16.22	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3RQW_C_ACHC323_0 (ELIC PENTAMERIC LIGAND GATED ION CHANNEL FROM ERWINIA CHRYSANTHEMI)	Acetylcholine	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	4 / 8		TYR C  94 GLU C 113 LEU C 122 PHE C 120	1.32A	13.12	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4PM5_A_CE3A301_1 (BETA-LACTAMASE CTX-M-14)	Cefotaxime	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	5 / 12		GLY B 272 TYR B 269 ASN B 268 THR B 302 GLY A 154	1.50A	21.62	None None None None AYE  A 155 ( 2.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3HUO_A_PNNA300_0 (CTX-M-9 EXTENDED-SPECTRUM BETA-LACTAMASE)	Benzylpenicillin	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	5 / 12		GLY A 154 ASN B 110 GLY B 164 GLY B 161 ASP B 109	1.56A	15.21	AYE  A 155 ( 2.4A) AYE  A 155 ( 4.2A) None None None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FGL_B_CLQB303_0 (RIBOSYLDIHYDRONICOTI NAMIDE DEHYDROGENASE [QUINONE])	Chloroquine	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	5 / 11		HIS C 116 GLY D 164 GLY C 154 TYR D 274 GLU D 162	1.11A	16.60	None None AYE  C 155 (-2.3A) None None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1EKJ_E_ACTE3005_0 (BETA-CARBONIC ANHYDRASE)	Acetic acid	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	4 / 7		CYH D 112 GLY C 154 GLY D 272 TYR D 265	1.46A	23.55	AYE  C 155 (-1.6A) AYE  C 155 (-2.3A) AYE  C 155 ( 4.7A) None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3PWR_A_ROCA401_2 (PROTEASE)	Saquinavir	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	3 / 3		ARG C 153 VAL D 117 THR D 169	1.29A	18.95	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1YA4_A_CTXA1_1 (CES1 PROTEIN)	Tamoxifen	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	5 / 12		GLY A 136 LEU A  80 SER A  81 LEU A 140 LEU A 105	1.44A	10.06	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4LMN_A_EUIA503_1 (DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1)	Cobimetinib	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	5 / 12		LEU A  80 ILE A  82 GLY A 139 LEU A 135 MET A 129	1.28A	13.39	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4G0V_A_MIXA1301_1 (DNA TOPOISOMERASE 2-BETA)	Mitoxantrone	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	4 / 7		ARG C 151 GLY D 164 GLU D 162 MET D 244	1.06A	8.82	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4LB0_B_ACTB401_0 (UNCHARACTERIZED PROTEIN)	Acetic acid	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	4 / 5		GLU A 113 VAL A 109 LEU A 122 VAL A 146	1.50A	14.94	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3B0W_B_DGXB1_2 (NUCLEAR RECEPTOR ROR-GAMMA)	Digoxin	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	3 / 3		LEU A 152 VAL B 304 ARG B 167	1.60A	18.01	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1TUB_B_TXLB501_1 (TUBULIN)	Docetaxel	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	5 / 12		ASP D  38 SER D  86 THR D 169 ARG C 151 GLY D 161	1.44A	22.17	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3CS9_D_NILD600_2 (PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL1)	Nilotinib	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	4 / 6		TYR C  94 VAL C  96 LEU C 122 ASP C 103	1.46A	16.23	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4GKI_G_KANG301_1 (AMINOGLYCOSIDE 3'-PHOSPHOTRANSFERAS E APHA1-IAB)	Kanamycin	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	4 / 8		ASP C 131 ASP C 118 GLU D 162 GLU C 117	1.55A	16.06	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1GTI_F_CCSF47_0 (GLUTATHIONE S-TRANSFERASE)	Carbocisteine	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	4 / 5		THR A  99 LEU A 135 GLY A 136 LYS A  79	1.57A	18.10	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FMO_E_ADNE351_1 (CAMP-DEPENDENT PROTEIN KINASE)	Adenosine	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	5 / 12		LEU A 152 GLY B 164 VAL A 115 GLU B 168 ASP A 118	1.40A	13.33	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1EQG_B_IBPB1701_1 (PROSTAGLANDIN H2 SYNTHASE-1)	Ibuprofen	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	5 / 11		VAL C 146 VAL C  96 TYR C  94 LEU C 105 LEU C 140	1.38A	8.73	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ZZ1_A_SHHA2452_1 (HISTONE DEACETYLASE-LIKE AMIDOHYDROLASE)	Vorinostat	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	5 / 11		LEU C 140 ILE C  82 HIS C 149 PHE C 124 GLY C 126	1.68A	12.46	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3PGH_D_FLPD701_1 (CYCLOOXYGENASE-2)	Flurbiprofen	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	5 / 12		TYR B 269 LEU A 152 GLY B 210 ALA B 247 SER B 246	1.24A	19.04	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1DX6_A_GNTA602_1 (ACETYLCHOLINESTERASE)	Galantamine	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	5 / 12		ASP D 109 GLY D 272 GLY C 154 GLY D 164 TYR D 113	1.31A	21.42	None AYE  C 155 ( 4.7A) AYE  C 155 (-2.3A) None None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3Q70_A_RITA2001_1 (CANDIDAPEPSIN-2)	Ritonavir	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	5 / 12		ILE C 147 GLY C  89 GLY D 210 SER D 246 ILE D 223	1.26A	14.56	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ERO_C_210C804_1 (FUSICOCCADIENE SYNTHASE)	Pamidronate	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	5 / 10		ASP A 118 ARG A 151 ASP A 131 ASP A 103 LYS A 107	1.29A	11.90	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FO4_A_SALA3005_1 (XANTHINE DEHYDROGENASE)	Salicylic acid	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	5 / 9		GLU A 113 ARG A  85 THR A 145 VAL A 146 LEU A 122	1.73A	5.23	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5T0M_B_SAMB1205_0 (HISTONE-LYSINE N-METHYLTRANSFERASE EHMT2)	S-Adenosylmethionine	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	5 / 12		TYR A  94 ASN A  86 HIS A 149 PHE A 120 GLN A 119	1.64A	13.88	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4GKH_G_KANG301_1 (AMINOGLYCOSIDE 3'-PHOSPHOTRANSFERAS E APHA1-IAB)	Kanamycin	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	4 / 7		ASP C 131 ASP C 118 GLU D 162 GLU C 117	1.55A	16.06	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3TL9_A_ROCA401_2 (PROTEASE)	Saquinavir	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	3 / 3		ARG C 153 VAL D 117 THR D 169	1.23A	19.19	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1EQH_A_FLPA701_1 (PROSTAGLANDIN H2 SYNTHASE-1)	Flurbiprofen	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	5 / 12		TYR B 269 LEU A 152 GLY B 210 ALA B 247 SER B 246	1.32A	19.25	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4OAD_A_CLMA205_0 (GNAT SUPERFAMILY ACETYLTRANSFERASE PA4794)	Chloramphenicol	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	5 / 12		PHE C 120 GLU D 168 ARG C 151 GLY C 154 TYR D 265	1.68A	16.56	None None None AYE  C 155 (-2.3A) None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4A7T_A_5FWA1001_1 (SUPEROXIDE DISMUTASE [CU-ZN])	Isoprenaline	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	3 / 3		ASP A 131 LYS A 132 ASP A 103	1.14A	18.24	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MX1_F_THAF6_1 (LIVER CARBOXYLESTERASE I)	Tacrine	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	5 / 12		GLY A 139 VAL A 146 LEU A  98 LEU A 140 LEU A 134	1.40A	8.39	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2EJT_A_SAMA501_1 (N(2),N(2)-DIMETHYLGU ANOSINE TRNA METHYLTRANSFERASE)	S-Adenosylmethionine	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	3 / 3		ARG A 127 ASP A 131 ASP A 118	1.76A	12.86	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ERO_B_210B804_1 (FUSICOCCADIENE SYNTHASE)	Pamidronate	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	5 / 9		ASP A 118 ARG A 151 ASP A 131 ASP A 103 LYS A 107	1.58A	11.90	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1V8B_A_ADNA502_2 (ADENOSYLHOMOCYSTEINA SE)	Adenosine	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	3 / 3		GLU B 204 GLU A  87 LEU A 122	1.28A	20.33	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4A97_C_ZPCC1318_1 (CYS-LOOP LIGAND-GATED ION CHANNEL)	Eszopiclone	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	5 / 12		PHE C 124 VAL C 146 GLU C 130 GLU C 133 VAL C  96	1.64A	13.42	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4M11_C_MXMC606_2 (PROSTAGLANDIN G/H SYNTHASE 2)	Meloxicam	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	3 / 3		LEU C 152 ARG C 151 MET C 129	1.39A	9.54	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3JZJ_A_ACRA405_1 (ACARBOSE/MALTOSE BINDING PROTEIN GACH)	Acarbose	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	5 / 12		GLU B 168 PHE A 120 ARG A 151 GLU A 117 ASP A 131	1.36A	21.91	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2XFH_A_CL6A1414_1 (ERYTHROMYCIN B/D C-12 HYDROXYLASE)	Clotrimazole	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	4 / 8		LEU C  80 ILE C  82 LEU C 140 LEU C  98	0.97A	11.60	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1UWH_A_BAXA1723_1 (B-RAF PROTO-ONCOGENE SERINE/THREONINE-PRO TEIN KINASE)	Sorafenib	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	5 / 12		LEU C  98 LEU C 140 CYH C 144 GLY C 139 PHE C 124	1.64A	15.58	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2AVV_E_MK1E902_4 (POL POLYPROTEIN)	Indinavir	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	3 / 3		ARG D  83 VAL C 102 GLY C 136	0.89A	15.61	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FZV_A_SAMA401_1 (PUTATIVE METHYLTRANSFERASE NSUN4)	S-Adenosylmethionine	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	3 / 3		ASP C 118 ARG C 151 ASP C 103	1.75A	12.81	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FBM_B_RTLB951_1 (PROTEIN (CARTILAGE OLIGOMERIC MATRIX PROTEIN))	Vitamin A	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	4 / 4		THR C  99 LEU C 135 VAL C 102 LEU C 122	1.35A	23.08	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2A3C_A_PNXA1435_1 (CHITINASE)	Pentoxifylline	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	4 / 6		TYR C  94 PHE C 124 SER C 123 ARG C  85	1.67A	11.55	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3TEH_B_DAHB786_1 (PHENYLALANYL-TRNA SYNTHETASE BETA CHAIN)	Levodopa	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	4 / 7		PRO B 248 GLY B 210 GLU A  87 ALA B 247	1.40A	17.45	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3NDU_D_ROCD100_3 (PROTEASE)	Saquinavir	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	3 / 3		ARG C 153 VAL D 117 THR D 169	1.24A	18.75	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3L2V_A_RLTA397_1 (INTEGRASE)	Raltegravir	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	4 / 7		ASP C 103 GLN C 100 GLN C 111 GLU C 117	1.59A	11.85	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2VXA_G_RBFG200_1 (DODECIN)	Riboflavin	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	4 / 8		ARG A 151 GLN A 119 TRP A 121 THR B 171	1.51A	18.52	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3K9F_F_LFXF0_1 (DNA TOPOISOMERASE 4 SUBUNIT A DNA TOPOISOMERASE 4 SUBUNIT B)	Levofloxacin	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	4 / 5		SER B 246 ARG A 151 GLY B 164 GLU B 162	1.31A	19.35 18.71	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HHJ_A_GLYA403_0 (RETRON-TYPE REVERSE TRANSCRIPTASE)	Glycine	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	4 / 4		LEU C 140 LEU C  98 GLY C 136 GLU C 137	1.58A	14.89	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3WZE_A_BAXA1201_1 (VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2)	Sorafenib	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	5 / 12		LEU B 174 GLU A  87 ILE B 223 PHE B 242 GLY B 202	1.32A	22.16	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3CYX_A_ROCA201_2 (HIV-1 PROTEASE)	Saquinavir	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	3 / 3		ARG C 153 VAL D 117 THR D 169	1.15A	18.95	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6C71_B_NCTB501_1 (AMINE OXIDASE)	Nicotine	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	4 / 8		LEU A 105 TYR A  94 GLU A 113 ASN A  86	1.32A	9.26	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2YGO_A_PCFA1213_1 (WNT INHIBITORY FACTOR 1)	Colfosceril palmitate	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	4 / 6		LEU A 135 ARG A 127 MET A 129 VAL B 226	1.44A	14.89	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6B89_B_NOVB403_1 (LIPOPOLYSACCHARIDE EXPORT SYSTEM ATP-BINDING PROTEIN LPTB)	Novobiocin	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	4 / 7		PHE A 120 ARG A 151 ARG A 153 GLN A 111	1.40A	19.68	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1X70_A_715A801_2 (DIPEPTIDYL PEPTIDASE IV)	Sitagliptin	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	3 / 3		ARG A 127 SER A  81 TYR A  94	1.46A	8.55	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4OLT_A_GCSA303_1 (CHITOSANASE)	Glucosamine	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	4 / 6		ASP D 165 ARG D 167 VAL D 203 HIS C 149	1.55A	24.40	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1EE2_B_CHDB1250_0 (ALCOHOL DEHYDROGENASE)	Cholic Acid	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	3 / 3		MET C 129 LEU C 122 SER C 123	1.35A	13.15	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FM9_A_9CRA201_2 (RETINOIC ACID RECEPTOR RXR-ALPHA)	Alitretinoin	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	3 / 3		GLN A 114 ILE A 147 HIS A 149	1.00A	17.41	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ABZ_A_T1CA1209_1 (TETRACYCLINE REPRESSOR CLASS D)	Tigecycline	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	5 / 12		SER C  91 HIS C 149 ARG C 127 THR C 145 LEU C 135	1.72A	16.91	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIP_B_HFGB1003_0 (PROLYL-TRNA SYNTHETASE, PUTATIVE)	Halofuginone	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	5 / 12		GLU A 117 VAL A 109 GLU B 168 HIS B 172 THR B 159	1.22A	9.68	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3RGF_A_BAXA465_2 (CYCLIN-DEPENDENT KINASE 8)	Sorafenib	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	4 / 7		LEU C 122 VAL C 109 LEU C 134 ASP C 103	1.22A	11.11	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4KM2_A_TOPA202_1 (DIHYDROFOLATE REDUCTASE)	Trimethoprim	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	5 / 12		ILE A 147 LEU A 105 VAL A 102 LEU A 135 ILE A  82	1.40A	17.05	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2AYL_A_FLPA1701_1 (PROSTAGLANDIN G/H SYNTHASE 1)	Flurbiprofen	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	5 / 12		TYR B 269 LEU A 152 GLY B 210 ALA B 247 SER B 246	1.10A	19.64	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4M11_D_MXMD606_1 (PROSTAGLANDIN G/H SYNTHASE 2)	Meloxicam	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	6 / 12		VAL A 109 ILE A 147 VAL A 146 LEU A 140 LEU A 122 VAL A  96	1.80A	9.54	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4EYS_A_ACTA402_0 (MCCC FAMILY PROTEIN)	Acetic acid	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	4 / 6		SER A 123 ASP B 165 ARG B 167 GLU A  87	0.99A	11.88	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1P7L_C_SAMC685_0 (S-ADENOSYLMETHIONINE SYNTHETASE)	S-Adenosylmethionine	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	4 / 8		ASP A 131 LYS B 158 SER B 156 THR B 171	1.22A	12.57	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1K74_A_9CRA463_2 (RETINOIC ACID RECEPTOR RXR-ALPHA)	Alitretinoin	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	3 / 3		GLN A 114 ILE A 147 HIS A 149	0.97A	17.41	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3O94_A_NCAA192_0 (NICOTINAMIDASE)	Nicotinamide	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	5 / 11		ASP A 103 LEU A 122 ASP A 131 PHE A 120 LEU A 105	1.77A	17.84	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ISM_B_NCAB305_0 (BONE MARROW STROMAL CELL ANTIGEN 1)	Nicotinamide	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	4 / 7		TRP C 121 HIS C 149 LEU C 150 PHE C 120	1.77A	13.58	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4PH9_A_IBPA601_1 (PROSTAGLANDIN G/H SYNTHASE 2)	Ibuprofen	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	5 / 10		VAL A 102 VAL A 146 LEU A 122 GLY A 139 LEU A 135	1.46A	9.54	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5LW1_E_ADNE401_1 (MITOGEN-ACTIVATED PROTEIN KINASE 8)	Adenosine	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	5 / 10		GLY A 154 ILE B 152 MET B 170 VAL B 117 LEU B 114	1.43A	12.06	AYE  A 155 ( 2.4A) None None None None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4MM5_A_SREA603_1 (TRANSPORTER)	Sertraline	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	5 / 9		ASP B 230 PRO B 248 GLY A  89 SER B 222 GLY B 210	1.64A	22.22	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FIQ_C_SALC1335_1 (XANTHINE OXIDASE)	Salicylic acid	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	5 / 8		GLU C 113 ARG C  85 THR C 145 VAL C 146 LEU C 122	1.69A	7.94	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5X7Z_A_BHAA201_0 (UNCHARACTERIZED HTH-TYPE TRANSCRIPTIONAL REGULATOR RV2887)	Aminosalicylic Acid	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	4 / 6		LEU A 122 VAL A 146 LEU A 140 VAL A  84	1.36A	19.50	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2PIV_A_T3A933_1 (ANDROGEN RECEPTOR)	Liothyronine	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	5 / 9		GLY A 154 ASN B 263 TYR B 265 GLU B 264 ARG B 285	1.50A	14.46	AYE  A 155 ( 2.4A) None None None None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4M11_C_MXMC606_1 (PROSTAGLANDIN G/H SYNTHASE 2)	Meloxicam	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	6 / 12		VAL A 109 ILE A 147 VAL A 146 LEU A 140 LEU A 122 VAL A  96	1.80A	9.54	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2KUH_A_HLTA150_1 (CALMODULIN)	Halothane	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	4 / 6		LEU C 122 LEU C 135 MET C 129 GLU C 130	1.67A	19.18	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FBM_B_RTLB951_3 (PROTEIN (CARTILAGE OLIGOMERIC MATRIX PROTEIN))	Vitamin A	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	4 / 5		THR C  99 LEU C 135 VAL C 102 LEU C 122	1.39A	23.08	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5E3I_B_HISB502_0 (HISTIDINE--TRNA LIGASE)	L-Histidine	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	5 / 11		GLN A 119 GLU B 168 TYR B 274 GLY A 154 GLY B 164	1.64A	11.11	None None None AYE  A 155 ( 2.4A) None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5BTI_E_LFXE101_1 (DNA GYRASE SUBUNIT A DNA GYRASE SUBUNIT B DNA SUBSTRATE 24-MER GGTCATGAATGACTATGCAC GTAA)	Levofloxacin	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	4 / 5		SER D 246 ARG C 151 GLY D 164 GLU D 162	1.38A	21.77 21.96	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5JW1_A_CELA602_1 (PROSTAGLANDIN G/H SYNTHASE 2)	Celecoxib	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	5 / 12		TYR B 269 LEU A 152 GLY B 210 ALA B 247 SER B 246	1.17A	20.79	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5W97_B_CHDB301_0 (CYTOCHROME C OXIDASE SUBUNIT 1 CYTOCHROME C OXIDASE SUBUNIT 2 CYTOCHROME C OXIDASE SUBUNIT 6A2, MITOCHONDRIAL)	Cholic Acid	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	5 / 11		GLY A  89 MET B 209 GLY B 210 GLN B 233 THR B 232	1.67A	15.29 7.63 16.59	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3NT1_A_NPSA5_1 (PROSTAGLANDIN-ENDOPE ROXIDE SYNTHASE 2)	Naproxen	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	5 / 12		TYR B 269 LEU A 152 GLY B 210 ALA B 247 SER B 246	1.13A	19.04	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ABM_B_CHDB1086_0 (CYTOCHROME C OXIDASE SUBUNIT 1 CYTOCHROME C OXIDASE SUBUNIT 2 CYTOCHROME C OXIDASE SUBUNIT 6A2)	Cholic Acid	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	5 / 11		MET B 209 GLY B 210 GLN B 233 THR B 232 GLY A  89	1.66A	19.57 21.65 14.57	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3EL0_A_1UNA201_2 (PROTEASE)	Nelfinavir	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	5 / 9		LEU C  83 VAL C  96 GLY C 139 PRO C 142 ILE C  82	1.52A	22.22	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1QAO_A_SAMA245_0 (ERMC' METHYLTRANSFERASE)	S-Adenosylmethionine	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	5 / 12		PHE A 120 ILE A  82 LEU A 122 ASN A  86 ILE A  93	1.26A	15.55	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BXM_A_SAMA402_0 (DIPHTHAMIDE BIOSYNTHESIS ENZYME DPH2)	S-Adenosylmethionine	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	5 / 12		GLY C  89 LEU D 217 VAL D 221 ARG C  85 ILE D 223	1.57A	12.58	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3S3O_A_DLUA399_1 (PFV INTEGRASE)	Dolutegravir	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	4 / 7		PRO A 128 GLN B 175 GLU A 130 ARG A 151	1.65A	11.85	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1KLM_A_SPPA999_1 (HIV-1 REVERSE TRANSCRIPTASE)	Delavirdine	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	5 / 11		LEU C 140 VAL C  96 TYR C 138 LEU C  98 PRO C  79	1.78A	9.30	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6MN4_E_AM2E301_0 (AMINOGLYCOSIDE N(3)-ACETYLTRANSFERA SE, AAC(3)-IVA)	Apramycin	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	4 / 7		TRP C 121 HIS D 172 THR D 171 GLU C 130	1.62A	17.00	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1X70_B_715B801_1 (DIPEPTIDYL PEPTIDASE IV)	Sitagliptin	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	5 / 12		GLU B 204 ARG A  85 VAL B 243 TYR B 208 VAL B 206	1.75A	17.31	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ZV2_B_LEVB801_2 (FIBROBLAST GROWTH FACTOR RECEPTOR 1)	Lenvatinib	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	3 / 3		TYR A  94 LEU A 122 ASP A 131	1.02A	13.71	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6GNG_B_QPSB601_2 (-)	Acarbose	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	5 / 12		GLY C 136 LEU C 135 GLY C 126 GLU D 204 PRO C 142	1.36A	8.17	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FPJ_B_SAMB301_0 (PUTATIVE UNCHARACTERIZED PROTEIN)	S-Adenosylmethionine	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	5 / 12		PHE C 124 ILE C  82 VAL C  84 ILE C  93 VAL C  96	1.69A	13.99	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5X7R_A_ACRA1481_1 (GLYCOSIDE HYDROLASE FAMILY 31 ALPHA-GLUCOSIDASE)	Acarbose	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	4 / 6		SER D 156 HIS D 172 ARG C 151 GLU D 168	1.50A	13.95	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1HPV_B_478B200_1 (HIV-1 PROTEASE)	Amprenavir	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	5 / 9		LEU C  83 VAL C  96 GLY C 139 PRO C 142 ILE C  82	1.56A	20.00	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1YA4_A_CTXA1_1 (CES1 PROTEIN)	Tamoxifen	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	5 / 12		ALA D 205 GLY C 126 SER C 123 MET D 244 HIS C 149	1.22A	20.52	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5YVN_A_ACTA305_0 (GLUTATHIONE S-TRANSFERASE OMEGA-1)	Acetic acid	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	4 / 6		LEU C 105 GLN C 100 LEU C  80 LEU C 140	1.62A	16.18	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4G1B_A_ECNA403_1 (FLAVOHEMOGLOBIN)	Econazole	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	5 / 12		THR C 145 VAL C 109 LEU C 105 TYR C  94 ILE C  93	1.30A	11.48	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1EQH_A_FLPA701_1 (PROSTAGLANDIN H2 SYNTHASE-1)	Flurbiprofen	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	5 / 12		VAL A 102 VAL A 146 LEU A 122 GLY A 139 LEU A 135	1.42A	8.73	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IA0_B_TXLB502_1 (TUBULIN BETA CHAIN)	Docetaxel	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	5 / 12		ASP D  38 SER D  86 THR D 169 ARG C 151 GLY D 161	1.44A	21.84	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Z3O_F_MFXF101_1 (DNA TOPOISOMERASE 4 SUBUNIT B,PARE30-PARC55 FUSED TOPO IV FROM S. PNEUMONIAE E-SITE DNA)	Moxifloxacin	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	4 / 5		ARG B 167 GLY A 126 GLU A 125 SER B 246	1.67A	17.21	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5IKT_B_TLFB601_0 (PROSTAGLANDIN G/H SYNTHASE 2)	Tolfenamic Acid	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	5 / 12		VAL A 102 VAL A 146 SER A 123 GLY A 139 LEU A 135	1.32A	10.79	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5B8I_C_FK5C201_1 (SERINE/THREONINE-PRO TEIN PHOSPHATASE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE)	Tacrolimus	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	4 / 6		LEU A 140 SER A 123 PRO A 128 GLU B 168	1.47A	12.50	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4PH9_A_IBPA601_1 (PROSTAGLANDIN G/H SYNTHASE 2)	Ibuprofen	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	5 / 10		TYR D 269 LEU C 152 GLY D 210 ALA D 247 SER D 246	1.39A	20.79	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JG4_A_SAMA500_0 (PROTEIN-L-ISOASPARTA TE O-METHYLTRANSFERASE)	S-Adenosylmethionine	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	5 / 12		THR C 145 VAL C  84 SER C  91 ASN C  86 GLY D 210	1.42A	13.45	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3N8Z_A_FLPA701_1 (PROSTAGLANDIN G/H SYNTHASE 1)	Flurbiprofen	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	5 / 12		VAL C 146 LEU C 134 TYR C 138 LEU C 140 LEU C 105	1.29A	9.56	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3HLW_B_CE3B302_1 (CTX-M-9 EXTENDED-SPECTRUM BETA-LACTAMASE)	Cefotaxime	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	5 / 12		GLY B 272 TYR B 269 ASN B 268 THR B 302 GLY A 154	1.42A	21.92	None None None None AYE  A 155 ( 2.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5T0M_A_SAMA1205_0 (HISTONE-LYSINE N-METHYLTRANSFERASE EHMT2)	S-Adenosylmethionine	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	5 / 12		TYR A  94 ASN A  86 HIS A 149 PHE A 120 GLN A 119	1.64A	13.88	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3K2H_A_LYAA514_1 (DIHYDROFOLATE REDUCTASE/THYMIDYLAT E SYNTHASE)	Pemetrexed	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	5 / 12		ALA D 247 ARG C  85 SER C 123 LEU C 150 TYR D 269	1.47A	19.84	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3PGH_A_FLPA701_1 (CYCLOOXYGENASE-2)	Flurbiprofen	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	5 / 12		VAL C 146 LEU C 134 TYR C 138 LEU C 140 LEU C 105	1.19A	8.90	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FEU_B_KANB301_1 (AMINOGLYCOSIDE 3'-PHOSPHOTRANSFERAS E APHA1-IAB)	Kanamycin	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	4 / 7		ASP C 131 ASP C 118 GLU D 162 GLU C 117	1.50A	16.06	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5CDQ_F_MFXF2101_1 (DNA GYRASE SUBUNIT A DNA GYRASE SUBUNIT B,DNA GYRASE SUBUNIT B)	Moxifloxacin	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	4 / 6		SER D 246 ARG C 151 GLY D 164 GLU D 162	1.41A	22.35 18.27	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HWK_A_BEZA301_0 (GLUTATHIONE-SPECIFIC GAMMA-GLUTAMYLCYCLOT RANSFERASE)	Benzoic Acid	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	5 / 10		GLY C 154 TYR D 274 GLY D 164 GLU D 168 TYR D 269	1.56A	13.75	AYE  C 155 (-2.3A) None None None None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIP_C_HFGC1003_0 (PROLYL-TRNA SYNTHETASE, PUTATIVE)	Halofuginone	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	5 / 12		GLU A 117 VAL A 109 GLU B 168 HIS B 172 THR B 159	1.23A	9.68	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3QXT_B_MTXB2000_1 (ANTI-METHOTREXATE CDR1-3 GRAFT VHH)	Methotrexate	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	5 / 12		LEU C 140 SER C  91 ARG C  85 MET C 129 VAL C 102	1.24A	18.03	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4X3M_B_ADNB301_1 (RNA 2'-O RIBOSE METHYLTRANSFERASE)	Adenosine	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	5 / 9		LEU C 105 ILE C  93 SER C  91 LEU C  83 VAL C 146	1.27A	12.84	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2PNJ_B_CHDB502_0 (FERROCHELATASE, MITOCHONDRIAL)	Cholic Acid	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	4 / 7		ILE C 147 ARG C  85 GLY D 210 MET D 245	1.32A	14.07	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5A06_A_SORA1342_0 (ALDOSE-ALDOSE OXIDOREDUCTASE)	Sorbitol	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	4 / 7		CYH A 144 LEU A 140 GLY A 136 GLY A 139	1.18A	12.06	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ELZ_C_CHDC150_0 (ILEAL BILE ACID-BINDING PROTEIN)	Cholic Acid	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	5 / 12		GLN D 175 VAL D 203 VAL C 146 LEU C 122 ILE C 147	1.61A	16.61	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ONI_A_BEZA502_0 (14.5 KDA TRANSLATIONAL INHIBITOR PROTEIN)	Benzoic Acid	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	4 / 6		ASN C  92 ASN C  86 ARG C  88 GLY C  89	1.57A	17.52	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5X7Q_A_ACRA1481_1 (GLYCOSIDE HYDROLASE FAMILY 31 ALPHA-GLUCOSIDASE)	Acarbose	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	4 / 6		SER D 156 HIS D 172 ARG C 151 GLU D 168	1.51A	13.95	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Z3O_F_MFXF101_1 (DNA TOPOISOMERASE 4 SUBUNIT B,PARE30-PARC55 FUSED TOPO IV FROM S. PNEUMONIAE E-SITE DNA)	Moxifloxacin	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	4 / 5		ARG A 151 GLY B 164 GLU B 162 SER B 246	1.44A	7.41	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FDU_B_ESTB354_1 (17-BETA-HYDROXYSTERO ID DEHYDROGENASE)	Estradiol	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	5 / 8		SER B 156 LEU B 174 PRO A 128 MET B 244 VAL B 206	1.73A	20.41	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1EQG_A_IBPA701_1 (PROSTAGLANDIN H2 SYNTHASE-1)	Ibuprofen	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	5 / 9		VAL C 146 VAL C  96 TYR C  94 LEU C 105 LEU C 140	1.38A	8.73	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6EW0_G_TA1G501_2 (TUBULIN BETA CHAIN)	Paclitaxel	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	4 / 6		LEU A 122 LEU A 140 THR A 101 PRO A  79	1.27A	9.43	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4B7N_A_ZMRA601_1 (NEURAMINIDASE)	Zanamivir	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	5 / 12		ARG A 127 GLU A 137 GLU A 133 ASN B 157 TYR A 138	1.78A	11.37	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FGZ_B_CQAB302_0 (PHOSPHOETHANOLAMINE N-METHYLTRANSFERASE)	Amodiaquine	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	4 / 8		GLU C 125 TYR C 138 ARG C 127 GLY C 136	1.49A	15.38	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4GKH_B_KANB301_1 (AMINOGLYCOSIDE 3'-PHOSPHOTRANSFERAS E APHA1-IAB)	Kanamycin	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	4 / 8		ASP C 131 ASP C 118 GLU D 162 GLU C 117	1.55A	16.06	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1DF7_A_MTXA501_1 (DIHYDROFOLATE REDUCTASE)	Methotrexate	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	5 / 12		ILE A 147 LEU A 105 VAL A 102 LEU A 135 ILE A  82	1.21A	17.31	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3K9F_H_LFXH0_1 (DNA TOPOISOMERASE 4 SUBUNIT A DNA TOPOISOMERASE 4 SUBUNIT B)	Levofloxacin	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	4 / 6		SER D 246 ARG C 153 GLY C 154 GLU D 162	1.30A	19.35 18.71	None None AYE  C 155 (-2.3A) None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4D7B_A_TCWA1126_1 (TRANSTHYRETIN)	Tolcapone	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	4 / 6		LEU C 105 LEU C 122 SER C 123 THR C 145	1.32A	19.53	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2F16_K_BO2K1402_1 (PROTEASOME COMPONENT PRE2 PROTEASOME COMPONENT C5)	Bortezomib	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	5 / 10		ALA D 205 THR D 201 ALA D 182 VAL D 206 GLY C 126	1.60A	20.74 22.66	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4PM7_A_CE3A301_1 (BETA-LACTAMASE CTX-M-14)	Cefotaxime	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	5 / 12		GLY B 272 TYR B 269 ASN B 268 THR B 302 GLY A 154	1.51A	21.62	None None None None AYE  A 155 ( 2.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2WD9_A_IBPA1570_1 (ACYL-COENZYME A SYNTHETASE ACSM2A, MITOCHONDRIAL)	Ibuprofen	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	5 / 7		LEU B 174 VAL B 203 GLY B 202 GLY A 126 ARG A 127	1.76A	21.28	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5KQX_A_ROCA101_2 (PROTEASE E35D-SQV)	Saquinavir	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	5 / 9		LEU C  83 VAL C  96 GLY C 139 PRO C 142 ILE C  82	1.56A	18.95	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6F7L_B_ACTB503_0 (AMINE OXIDASE LKCE)	Acetic acid	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	3 / 3		VAL C  96 GLU C  95 ILE C  82	0.65A	17.65	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1KIJ_B_NOVB444_2 (DNA GYRASE SUBUNIT B)	Novobiocin	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	3 / 3		ASP C 103 PHE C 120 VAL C 109	1.23A	13.35	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DEB_B_MTXB302_1 (BIFUNCTIONAL PROTEIN FOLD)	Methotrexate	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	5 / 12		LEU A 152 LEU A 150 ASP B 165 THR B 171 SER A 123	1.69A	12.89	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4U0I_A_0LIA1001_1 (MAST/STEM CELL GROWTH FACTOR RECEPTOR KIT,MAST/STEM CELL GROWTH FACTOR RECEPTOR KIT)	Ponatinib	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	5 / 10		LEU C  80 VAL C  96 ILE C 147 VAL C 146 VAL C 102	1.25A	15.02	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5SXT_A_NIZA807_1 (CATALASE-PEROXIDASE)	Isoniazid	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	4 / 8		GLU A 137 VAL A 102 GLY A 139 LEU A 140	1.30A	7.01	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3VYW_C_SAMC401_1 (MNMC2)	S-Adenosylmethionine	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	4 / 6		GLY B 161 GLU B 162 ASP A 131 ASP B  38	1.61A	21.68	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3SUG_A_SUEA1201_1 (NS3 PROTEASE, NS4A PROTEIN)	Grazoprevir	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	5 / 12		GLY C 154 VAL D 117 GLY D 267 THR D 302 ALA D 250	1.48A	17.50	AYE  C 155 (-2.3A) None None None None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3JWQ_C_VIAC901_1 (CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE CATALYTIC DOMAIN, CONE CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE SUBUNIT ALPHA CHIMERA)	Sildenafil	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	4 / 7		HIS C 149 MET D 244 LEU D 212 VAL D 117	1.60A	13.80	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6NMP_O_CHDO302_0 (CYTOCHROME C OXIDASE SUBUNIT 1 CYTOCHROME C OXIDASE SUBUNIT 2 CYTOCHROME C OXIDASE SUBUNIT 6A2, MITOCHONDRIAL)	Cholic Acid	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	5 / 10		GLY A  89 MET B 209 GLY B 210 GLN B 233 THR B 232	1.61A	15.29 7.63 16.59	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2QD2_A_CHDA2_0 (FERROCHELATASE)	Cholic Acid	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	4 / 8		LEU D 153 ARG C 153 ARG C 151 SER D  79	1.64A	20.55	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2AVV_E_MK1E902_1 (POL POLYPROTEIN)	Indinavir	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	6 / 12		LEU A  83 VAL A  96 GLY A 136 GLY A 139 PRO A 142 ILE A  82	1.58A	18.95	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2VDV_E_SAME1287_0 (TRNA (GUANINE-N(7)-)-METH YLTRANSFERASE)	S-Adenosylmethionine	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	5 / 12		GLU D 162 ALA D  40 ASP C 131 THR D 169 GLU D 168	1.44A	20.68	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3MNO_A_DEXA784_1 (GLUCOCORTICOID RECEPTOR)	Betamethasone	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	5 / 12		GLY A 139 MET A 129 VAL A 102 LEU A 122 THR A 145	1.64A	15.12	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3HLW_A_CE3A301_1 (CTX-M-9 EXTENDED-SPECTRUM BETA-LACTAMASE)	Cefotaxime	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	5 / 12		GLY B 272 TYR B 269 ASN B 268 THR B 302 GLY A 154	1.42A	21.92	None None None None AYE  A 155 ( 2.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4PGH_D_SAMD401_0 (CAFFEIC ACID O-METHYLTRANSFERASE)	S-Adenosylmethionine	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	5 / 12		SER D 156 GLY C 154 GLY D 164 THR D 169 TRP D 107	1.65A	21.72	None AYE  C 155 (-2.3A) None None AYE  C 155 ( 4.4A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HIE_B_P06B801_2 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	Dabrafenib	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	4 / 7		ILE D 286 GLY D 288 LEU C 152 CYH D 261	1.19A	22.32	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Z2D_F_LFXF102_1 (DNA GYRASE SUBUNIT A DNA GYRASE SUBUNIT B SYMMETRIZED E-SITE DNA)	Levofloxacin	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	3 / 4		ARG C 151 GLY D 164 GLU D 162	1.31A	11.11 15.66	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ELZ_B_CHDB150_0 (ILEAL BILE ACID-BINDING PROTEIN)	Cholic Acid	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	5 / 11		GLN D 175 VAL D 203 VAL C 146 LEU C 122 ILE C 147	1.64A	16.61	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6B0C_D_TA1D502_1 (TUBULIN BETA CHAIN)	Paclitaxel	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	5 / 12		LEU B 235 SER B 246 LEU B 186 THR B 198 GLY A 126	1.25A	21.84	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5X19_B_CHDB302_0 (CYTOCHROME C OXIDASE SUBUNIT 1 CYTOCHROME C OXIDASE SUBUNIT 2 CYTOCHROME C OXIDASE SUBUNIT 6A2, MITOCHONDRIAL)	Cholic Acid	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	5 / 11		MET B 209 GLY B 210 GLN B 233 THR B 232 GLY A  89	1.71A	19.57 21.65 14.57	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HG0_A_SAMA301_0 (PANTOTHENATE SYNTHETASE)	S-Adenosylmethionine	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	5 / 12		LEU A 140 GLN B 175 VAL B 203 GLY A 139 LEU A 134	1.36A	14.29	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RJD_B_TFPB204_1 (CALMODULIN)	Trifluoperazine	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	4 / 8		LEU C 140 GLY C 139 GLU C 133 GLU C 137	1.36A	16.25	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3TI5_A_ZMRA1002_1 (NEURAMINIDASE)	Zanamivir	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	5 / 12		ARG A 127 GLU A 137 GLU A 133 ASN B 157 TYR A 138	1.78A	13.43	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4LJ0_A_ACTA505_0 (NAB2)	Acetic acid	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	3 / 3		LEU C 105 LYS C 106 THR C 104	1.27A	18.29	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2XCT_G_CPFG1020_1 (DNA GYRASE SUBUNIT B, DNA GYRASE SUBUNIT A)	Ciprofloxacin	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	3 / 3		ARG A 153 GLY B 272 SER B 116	1.08A	7.46	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5T8S_B_SAMB402_1 (S-ADENOSYLMETHIONINE SYNTHASE)	S-Adenosylmethionine	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	4 / 8		LYS B 158 SER B 156 THR B 171 ASP A 131	1.72A	21.27	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6EW0_F_TA1F502_2 (TUBULIN BETA CHAIN)	Paclitaxel	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	4 / 5		LEU A 122 LEU A 140 THR A 101 PRO A  79	1.27A	9.43	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FGK_A_0TXA302_1 (RIBOSYLDIHYDRONICOTI NAMIDE DEHYDROGENASE [QUINONE])	Chloroquine	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	4 / 7		GLY D 164 GLY C 154 TYR D 274 GLU D 162	0.84A	22.12	None AYE  C 155 (-2.3A) None None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4O1Z_B_MXMB807_1 (PROSTAGLANDIN G/H SYNTHASE 1)	Meloxicam	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	5 / 12		MET A 129 LEU A 122 ILE A  82 VAL A  96 LEU A 135	1.45A	8.90	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3N8W_A_FLPA701_1 (PROSTAGLANDIN G/H SYNTHASE 1)	Flurbiprofen	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	5 / 12		TYR B 269 LEU A 152 GLY B 210 ALA B 247 SER B 246	1.15A	19.64	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5NZY_A_CE3A1103_1 (DNA CROSS-LINK REPAIR 1A PROTEIN)	Cefotaxime	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	4 / 8		THR B 171 TYR A 138 ASP B  77 VAL A 102	1.03A	21.27	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2VXA_A_RBFA200_1 (DODECIN)	Riboflavin	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	4 / 8		TYR D 269 ARG C 153 GLN C 119 HIS C 149	1.74A	13.71	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3EKQ_A_ROCA100_2 (PROTEASE)	Saquinavir	5tl7	UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus)	5 / 9		LEU C  83 VAL C  96 GLY C 139 PRO C 142 ILE C  82	1.57A	24.00	None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4G0V_D_MIXD101_1 (DNA TOPOISOMERASE 2-BETA)	Mitoxantrone	5tl7	REPLICASE POLYPROTEIN 1AB UBIQUITIN-LIKE PROTEIN ISG15 (Mus musculus; SARSr-CoV)	4 / 6		ARG C 151 GLY D 164 GLU D 162 MET D 244	0.97A	8.82	None