SIMILAR PATTERN OF AMINO ACIDS MAPPED TO UNIPROT ID 'P59635'

DrReposER ID / Desc. Drug Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM6_A_29EA603_1
(TRANSPORTER)		Duloxetine1xak ORF7A ACCESSORY
PROTEIN
(SARSr-CoV)		5 / 12
ALA A  49
TYR A  60
PHE A  31
SER A  29
GLY A  27
1.52A10.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_E_TRPE81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		L-Tryptophan1xak ORF7A ACCESSORY
PROTEIN
(SARSr-CoV)		4 / 6
SER A  29
GLY A  11
THR A  46
THR A  44
1.36A22.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA300_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		Hydralazine1xak ORF7A ACCESSORY
PROTEIN
(SARSr-CoV)		4 / 6
PHE A  39
TYR A  25
THR A  59
PHE A  48
1.62A18.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I45_A_NIOA500_1
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN)		Niacin1xak ORF7A ACCESSORY
PROTEIN
(SARSr-CoV)		4 / 8
SER A  29
LEU A  41
TYR A  25
LEU A  16
1.40A13.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLB_A_NVPA999_1
(HIV-1 RT A-CHAIN)		Nevirapine1xak ORF7A ACCESSORY
PROTEIN
(SARSr-CoV)		4 / 8
LEU A  41
TYR A  60
GLY A  27
LEU A  62
1.22A9.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_A_STRA604_1
(CYTOCHROME P450
21-HYDROXYLASE)		Progesterone1xak ORF7A ACCESSORY
PROTEIN
(SARSr-CoV)		5 / 12
SER A  45
VAL A  67
GLY A  11
VAL A  14
LEU A  62
1.50A9.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMD_B_29EB603_1
(TRANSPORTER)		Duloxetine1xak ORF7A ACCESSORY
PROTEIN
(SARSr-CoV)		5 / 12
ALA A  49
TYR A  60
PHE A  31
SER A  29
GLY A  27
1.51A10.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		Tamoxifen1xak ORF7A ACCESSORY
PROTEIN
(SARSr-CoV)		4 / 4
LEU A  62
PRO A  33
ILE A  15
LEU A  16
1.27A9.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1351_1
(PROSTAGLANDIN
REDUCTASE 2)		Phenylbutazone1xak ORF7A ACCESSORY
PROTEIN
(SARSr-CoV)		5 / 10
TYR A  60
PHE A  39
TYR A   5
VAL A  14
LEU A  41
1.65A12.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_A_SAMA801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		S-Adenosylmethionine1xak ORF7A ACCESSORY
PROTEIN
(SARSr-CoV)		5 / 12
ILE A  15
THR A  12
ALA A  40
PHE A  48
LEU A  34
1.57A16.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_G_TRPG81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		L-Tryptophan1xak ORF7A ACCESSORY
PROTEIN
(SARSr-CoV)		4 / 7
SER A  29
GLY A  11
THR A  46
THR A  44
1.35A22.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4007_1
(SERUM ALBUMIN)		Halothane1xak ORF7A ACCESSORY
PROTEIN
(SARSr-CoV)		5 / 8
TYR A  25
LEU A  34
HIS A  32
PHE A  31
LEU A  41
1.61A9.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA503_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		Salicylic acid1xak ORF7A ACCESSORY
PROTEIN
(SARSr-CoV)		4 / 6
LYS A  38
ILE A  15
VAL A  14
LEU A  41
1.46A16.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_A_8PRA603_1
(TRANSPORTER)		Paroxetine1xak ORF7A ACCESSORY
PROTEIN
(SARSr-CoV)		5 / 12
ALA A  49
TYR A  60
PHE A  31
SER A  29
GLY A  27
1.47A10.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		Cholic Acid1xak ORF7A ACCESSORY
PROTEIN
(SARSr-CoV)		4 / 6
LEU A  62
GLN A  61
LEU A  41
PHE A  39
1.45A14.18
23.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_A_BEZA302_0
(DISULFIDE
INTERCHANGE PROTEIN)		Benzoic Acid1xak ORF7A ACCESSORY
PROTEIN
(SARSr-CoV)		4 / 6
PRO A  19
HIS A   4
LYS A  -1
ALA A  51
1.78A20.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_1
(TRANSPORTER)		Paroxetine1xak ORF7A ACCESSORY
PROTEIN
(SARSr-CoV)		5 / 12
ALA A  49
TYR A  60
PHE A  31
SER A  29
GLY A  27
1.50A10.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CI6_A_NBOA607_1
(SERUM ALBUMIN)		Nabumetone1xak ORF7A ACCESSORY
PROTEIN
(SARSr-CoV)		4 / 7
ASP A  54
ALA A  51
GLU A  18
LEU A   2
1.65A10.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_E_TFPE212_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		Trifluoperazine1xak ORF7A ACCESSORY
PROTEIN
(SARSr-CoV)		4 / 7
PHE A  48
PHE A  31
LEU A  34
PHE A  50
1.40A20.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1498_1
(CYTOCHROME P450 3A4)		Ketoconazole1xak ORF7A ACCESSORY
PROTEIN
(SARSr-CoV)		5 / 11
ILE A  15
PHE A  39
ALA A  40
ARG A  63
LEU A  62
1.58A12.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LK0_D_Z80D92_1
(PROTEIN S100-B)		Chlorpromazine1xak ORF7A ACCESSORY
PROTEIN
(SARSr-CoV)		3 / 3
HIS A  32
PHE A  50
PHE A  48
1.53A17.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_A_NIOA604_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		Niacin1xak ORF7A ACCESSORY
PROTEIN
(SARSr-CoV)		4 / 5
THR A  24
PHE A  50
GLU A  26
GLY A  27
1.67A16.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM3_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		Doxycycline1xak ORF7A ACCESSORY
PROTEIN
(SARSr-CoV)		4 / 6
LEU A  41
SER A  29
PHE A  48
HIS A  47
1.44A16.79
18.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1356_1
(PROSTAGLANDIN
REDUCTASE 2)		Phenylbutazone1xak ORF7A ACCESSORY
PROTEIN
(SARSr-CoV)		5 / 8
TYR A  60
PHE A  39
TYR A   5
VAL A  14
LEU A  41
1.71A12.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_A_ACRA602_2
(-)		Acarbose1xak ORF7A ACCESSORY
PROTEIN
(SARSr-CoV)		4 / 6
TYR A  25
HIS A  47
TYR A  60
GLU A   1
1.78A9.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PO7_A_ZONA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		Zonisamide1xak SARS ORF7A ACCESSORY
PROTEIN
(SARSr)		4 / 8
TYR A  60
LEU A  41
PHE A  39
TYR A  25
1.29A9.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQY_A_BEZA401_0
(THIOREDOXIN)		Benzoic Acid1xak ORF7A ACCESSORY
PROTEIN
(SARSr-CoV)		4 / 8
ILE A  15
PHE A  39
VAL A  14
SER A  29
1.34A20.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_T_TRPT81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		L-Tryptophan1xak ORF7A ACCESSORY
PROTEIN
(SARSr-CoV)		4 / 7
GLY A  11
THR A  46
THR A  44
SER A  29
1.28A22.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		Pemetrexed1xak ORF7A ACCESSORY
PROTEIN
(SARSr-CoV)		5 / 12
ALA A  64
LEU A  62
THR A  13
LEU A  16
LEU A  41
1.48A11.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		Cholic Acid1xak SARS ORF7A ACCESSORY
PROTEIN
(SARSr)		4 / 7
LEU A  62
GLN A  61
LEU A  41
PHE A  39
1.38A14.18
23.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1500_1
(CYTOCHROME P450 3A4)		Ketoconazole1xak ORF7A ACCESSORY
PROTEIN
(SARSr-CoV)		5 / 11
ILE A  15
PHE A  39
ALA A  40
ARG A  63
LEU A  62
1.46A12.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_1
(ADENOSINE DEAMINASE)		Pentostatin1xak ORF7A ACCESSORY
PROTEIN
(SARSr-CoV)		5 / 12
HIS A  58
PHE A  39
PHE A  31
ALA A  49
HIS A   4
1.58A12.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		Diclofenac1xak ORF7A ACCESSORY
PROTEIN
(SARSr-CoV)		4 / 8
TYR A  60
LEU A  41
LEU A  16
LYS A  38
1.53A11.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		Cholic Acid1xak ORF7A ACCESSORY
PROTEIN
(SARSr-CoV)		4 / 6
LEU A  62
GLN A  61
LEU A  41
PHE A  39
1.57A14.18
23.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		Remikiren1xak ORF7A ACCESSORY
PROTEIN
(SARSr-CoV)		5 / 12
GLY A  11
SER A  45
THR A  46
VAL A  14
SER A  29
1.74A14.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		Cholic Acid1xak ORF7A ACCESSORY
PROTEIN
(SARSr-CoV)		4 / 7
LEU A  62
GLN A  61
LEU A  41
PHE A  39
1.47A14.18
23.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		Colfosceril palmitate1xak ORF7A ACCESSORY
PROTEIN
(SARSr-CoV)		4 / 5
LEU A  16
LYS A  38
ALA A  40
LEU A  34
1.60A3.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM9_A_FVXA603_1
(TRANSPORTER)		Fluvoxamine1xak ORF7A ACCESSORY
PROTEIN
(SARSr-CoV)		5 / 11
ALA A  49
TYR A  60
PHE A  31
SER A  29
GLY A  27
1.63A10.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA142_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		Acetic acid1xak ORF7A ACCESSORY
PROTEIN
(SARSr-CoV)		4 / 5
GLU A  18
PRO A  21
GLY A  23
LYS A  17
1.62A19.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBL_A_CAMA517_0
(CYTOCHROME P450-CAM)		Camphor1xak ORF7A ACCESSORY
PROTEIN
(SARSr-CoV)		4 / 7
PHE A  39
TYR A  25
THR A  46
VAL A  14
1.43A11.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_E_ACTE403_0
(PROTON-GATED ION
CHANNEL)		Acetic acid1xak ORF7A ACCESSORY
PROTEIN
(SARSr-CoV)		3 / 3
ARG A  57
TYR A   3
GLU A   1
1.28A14.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA508_0
(CHORISMATE SYNTHASE)		Acetic acid1xak ORF7A ACCESSORY
PROTEIN
(SARSr-CoV)		4 / 5
LEU A  34
ASP A  36
ALA A  35
ILE A  15
1.62A11.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_1
(ADENOSINE DEAMINASE)		Pentostatin1xak ORF7A ACCESSORY
PROTEIN
(SARSr-CoV)		5 / 12
HIS A  58
PHE A  39
PHE A  31
ALA A  49
HIS A   4
1.57A12.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_B_NCTB501_1
(CYTOCHROME P450 2A13)		Nicotine1xak ORF7A ACCESSORY
PROTEIN
(SARSr-CoV)		5 / 8
PHE A  39
PHE A  50
ALA A  49
THR A  59
LEU A  62
1.65A10.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_A_SALA257_1
(TRANSCRIPTIONAL
REGULATOR)		Salicylic acid1xak ORF7A ACCESSORY
PROTEIN
(SARSr-CoV)		4 / 8
SER A  29
PHE A  39
THR A  13
ILE A  15
1.32A18.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_C_CHDC310_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		Cholic Acid1xak SARS ORF7A ACCESSORY
PROTEIN
(SARSr)		4 / 7
LEU A  62
GLN A  61
LEU A  41
PHE A  39
1.49A14.18
23.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_A_CHDA103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		Cholic Acid1xak ORF7A ACCESSORY
PROTEIN
(SARSr-CoV)		5 / 8
LEU A  16
LEU A  41
GLU A   7
ALA A  64
LEU A  62
1.62A10.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_F_TFPF211_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		Trifluoperazine1xak ORF7A ACCESSORY
PROTEIN
(SARSr-CoV)		4 / 7
PHE A  48
PHE A  31
LEU A  34
PHE A  50
1.31A20.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		Cholic Acid1xak ORF7A ACCESSORY
PROTEIN
(SARSr-CoV)		4 / 6
LEU A  62
GLN A  61
LEU A  41
PHE A  39
1.57A14.18
23.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_2
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		Lisinopril1xak ORF7A ACCESSORY
PROTEIN
(SARSr-CoV)		3 / 3
ALA A  40
THR A  13
PHE A  31
1.04A10.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_E_SAME301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		S-Adenosylmethionine1xak ORF7A ACCESSORY
PROTEIN
(SARSr-CoV)		5 / 12
ALA A  49
ASP A  54
PRO A  21
GLY A  23
SER A  22
1.59A15.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AWU_A_4CHA503_0
(OXIDOREDUCTASE,
FMN-BINDING)		Parachlorophenol1xak ORF7A ACCESSORY
PROTEIN
(SARSr-CoV)		4 / 6
SER A  29
PHE A  31
PHE A  39
PHE A  48
1.65A13.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_E_MFXE2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		Moxifloxacin1xak ORF7A ACCESSORY
PROTEIN
(SARSr-CoV)		4 / 5
SER A  22
ARG A  57
GLY A  55
GLU A   1
1.66A10.53
17.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L7I_B_SAMB501_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		S-Adenosylmethionine1yo4 HYPOTHETICAL PROTEIN
X4
(SARSr-CoV)		4 / 8
HIS A  47
ALA A  49
TYR A  25
SER A  29
1.25A11.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PHH_A_LDPA414_1
(LYSINE-SPECIFIC
DEMETHYLASE 4D)		Dopamine1yo4 HYPOTHETICAL PROTEIN
X4
(SARSr-CoV)		4 / 6
GLU A  77
ARG A  63
ALA A  64
SER A  66
1.73A11.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WCX_C_SAMC503_0
(BIOTIN AND THIAMIN
SYNTHESIS ASSOCIATED)		S-Adenosylmethionine1yo4 HYPOTHETICAL PROTEIN
X4
(SARSr-CoV)		5 / 12
TYR A   3
TYR A   5
GLU A  81
PHE A  48
HIS A   4
1.52A9.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_2
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		Lisinopril1yo4 HYPOTHETICAL PROTEIN
X4
(SARSr-CoV)		3 / 3
ALA A  40
THR A  13
PHE A  31
1.14A10.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		S-Adenosylmethionine1yo4 HYPOTHETICAL PROTEIN
X4
(SARSr-CoV)		4 / 8
HIS A  47
ALA A  49
TYR A  25
SER A  29
1.26A11.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		Acetylcholine1yo4 HYPOTHETICAL PROTEIN
X4
(SARSr-CoV)		4 / 8
THR A  46
GLN A  61
TYR A   5
CYH A  43
1.50A18.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		Mannitol1yo4 HYPOTHETICAL PROTEIN
X4
(SARSr-CoV)		4 / 8
SER A  29
GLN A  61
PHE A  48
ASN A  28
1.69A12.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_B_ACTB1463_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		Acetic acid1yo4 HYPOTHETICAL PROTEIN
X4
(SARSr-CoV)		4 / 7
VAL A   9
VAL A  67
GLY A  11
THR A  12
1.09A11.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KI6_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		Phenol1yo4 HYPOTHETICAL PROTEIN
X4
(SARSr-CoV)		4 / 5
LEU A  16
TYR A  25
LEU A  62
TYR A  60
1.80A8.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_B_9PLB1_1
(CYTOCHROME P450 2A13)		Pilocarpine1yo4 HYPOTHETICAL PROTEIN
X4
(SARSr-CoV)		4 / 6
PHE A  39
PHE A  31
PHE A  50
ALA A  49
1.53A11.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMB_A_PXBA692_1
(LACTOTRANSFERRIN)		Parecoxib1yo4 HYPOTHETICAL PROTEIN
X4
(SARSr-CoV)		3 / 3
PRO A  19
GLU A   1
TYR A  60
1.58A14.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_A_NIOA221_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		Niacin1yo4 HYPOTHETICAL PROTEIN
X4
(SARSr-CoV)		4 / 6
THR A  59
PHE A  48
PHE A  39
GLU A  26
1.49A14.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		Celecoxib1yo4 HYPOTHETICAL PROTEIN
X4
(SARSr-CoV)		4 / 7
ARG A  65
SER A  68
LEU A  82
ILE A  73
1.54A8.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_B_SAMB500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		S-Adenosylmethionine1yo4 HYPOTHETICAL PROTEIN
X4
(SARSr-CoV)		5 / 12
ALA A  40
HIS A  58
TYR A  60
CYH A  52
CYH A  20
1.54A14.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1498_1
(CYTOCHROME P450 3A4)		Ketoconazole1yo4 HYPOTHETICAL PROTEIN
X4
(SARSr-CoV)		5 / 11
LEU A  41
PHE A  48
ALA A  49
THR A  59
GLU A  81
1.69A10.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OMB_D_IPHD2002_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		Phenol1yo4 HYPOTHETICAL PROTEIN
X4
(SARSr-CoV)		4 / 7
HIS A  58
TYR A   3
HIS A   4
TYR A  60
1.62A16.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_2
(VITAMIN D RECEPTOR)		Calcitriol1yo4 HYPOTHETICAL PROTEIN
X4
(SARSr-CoV)		4 / 7
LEU A  16
LEU A  41
ARG A  10
TYR A   5
1.12A15.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_A_LURA201_1
(TRANSTHYRETIN)		Lumiracoxib1yo4 HYPOTHETICAL PROTEIN
X4
(SARSr-CoV)		3 / 3
LYS A  38
LEU A  15
ALA A  35
1.68A21.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_A_SAMA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		S-Adenosylmethionine1yo4 HYPOTHETICAL PROTEIN
X4
(SARSr-CoV)		5 / 12
ALA A  40
HIS A  58
TYR A  60
CYH A  52
CYH A  20
1.53A14.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_A_CHDA103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		Cholic Acid1yo4 HYPOTHETICAL PROTEIN
X4
(SARSr-CoV)		5 / 8
LEU A  16
LEU A  41
GLU A   7
ALA A  64
LEU A  62
1.62A9.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		Benzoic Acid1yo4 HYPOTHETICAL PROTEIN
X4
(SARSr-CoV)		4 / 6
PHE A  50
ALA A  49
HIS A   4
LEU A   2
1.62A17.87
11.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U8Q_A_NPUA7231_1
(LACTOTRANSFERRIN)		Phenylpropanolamine1yo4 HYPOTHETICAL PROTEIN
X4
(SARSr-CoV)		4 / 5
THR A  46
GLY A  27
PRO A  30
ASN A  28
1.75A15.46
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LB3_A_4CHA191_0
(DEHALOPEROXIDASE A)		Parachlorophenol1yo4 HYPOTHETICAL PROTEIN
X4
(SARSr-CoV)		4 / 6
PHE A  39
PHE A  48
TYR A  25
VAL A  14
1.45A18.46
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		Ciprofloxacin1yo4 HYPOTHETICAL PROTEIN
X4
(SARSr-CoV)		4 / 6
ARG A  57
GLY A  -2
THR A  59
GLU A   1
1.48A12.21
15.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_H_CVIH301_0
(REGULATORY PROTEIN
TETR)		Gentian Violet1yo4 HYPOTHETICAL PROTEIN
X4
(SARSr-CoV)		5 / 12
SER A  68
LEU A  71
ARG A  63
VAL A   9
CYH A   8
1.68A18.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EIG_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		Methotrexate1yo4 HYPOTHETICAL PROTEIN
X4
(SARSr-CoV)		5 / 12
LEU A  62
GLU A  18
SER A  29
PRO A  30
TYR A   3
1.67A18.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		Cholic Acid1yo4 HYPOTHETICAL PROTEIN
X4
(SARSr-CoV)		4 / 6
LEU A  62
GLN A  61
LEU A  41
PHE A  39
1.54A15.62
23.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2003_1
(SERUM ALBUMIN)		Diflunisal1yo4 HYPOTHETICAL PROTEIN
X4
(SARSr-CoV)		5 / 9
TYR A   3
LEU A  16
PHE A  39
LEU A  62
ALA A  49
1.77A10.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_1
(PUTATIVE
MODIFICATION
METHYLASE)		S-Adenosylmethionine1yo4 HYPOTHETICAL PROTEIN
X4
(SARSr-CoV)		3 / 3
ASP A  36
THR A  56
GLU A  18
1.23A15.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		Mannitol1yo4 HYPOTHETICAL PROTEIN
X4
(SARSr-CoV)		4 / 8
SER A  29
GLN A  61
PHE A  48
ASN A  28
1.69A12.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_A_STRA604_1
(CYTOCHROME P450
21-HYDROXYLASE)		Progesterone1yo4 HYPOTHETICAL PROTEIN
X4
(SARSr-CoV)		5 / 12
SER A  45
VAL A  67
GLY A  11
VAL A  14
LEU A  62
1.52A10.46
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZ8_A_GCSA208_1
(GLUCANASE/CHITOSANAS
E)		Glucosamine1yo4 HYPOTHETICAL PROTEIN
X4
(SARSr-CoV)		4 / 7
GLU A   1
TYR A   3
GLU A  26
ALA A  49
1.49A15.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JT9_A_ACAA7_1
(5-MER
IMMUNOSUPPRESSORY
PEPTIDE FROM
CYCLOLINOPEPTIDE X
MODIFIED 16-MER
IMMUNOSUPPRESSORY
PEPTIDE FROM
HOMEOTIC PROTEIN
ANTENNAPEDIA)		Aminocaproic Acid1yo4 HYPOTHETICAL PROTEIN
X4
(SARSr-CoV)		4 / 5
LEU A  16
LEU A  15
ARG A  63
GLN A   6
1.57A17.65
10.96
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_G_BEZG3385_0
(CES1 PROTEIN)		Benzoic Acid1yo4 HYPOTHETICAL PROTEIN
X4
(SARSr-CoV)		3 / 3
SER A  29
VAL A  14
LEU A  41
1.35A9.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_A_BEZA524_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		Benzoic Acid1yo4 HYPOTHETICAL PROTEIN
X4
(SARSr-CoV)		4 / 6
THR A  59
PHE A  48
PHE A  39
GLU A  26
1.47A16.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K87_A_ADNA602_1
(PROLINE--TRNA LIGASE)		Adenosine1yo4 HYPOTHETICAL PROTEIN
X4
(SARSr-CoV)		4 / 8
ARG A  63
GLY A  11
THR A  12
THR A  44
1.37A11.46
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA813_0
(GEPHYRIN)		Acetic acid1yo4 HYPOTHETICAL PROTEIN
X4
(SARSr-CoV)		3 / 3
THR A  13
ALA A  40
LYS A  38
1.62A12.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZV_B_ECNB411_1
(FLAVOHEMOGLOBIN)		Econazole1yo4 HYPOTHETICAL PROTEIN
X4
(SARSr-CoV)		5 / 9
PHE A  39
TYR A  25
LEU A  62
LEU A  16
ALA A  40
1.56A12.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5INZ_D_DVAD15_0
(THETA DEFENSIN-2,
D-PEPTIDE
THETA DEFENSIN-2,
L-PEPTIDE)		L-Valine1yo4 HYPOTHETICAL PROTEIN
X4
(SARSr-CoV)		3 / 3
GLY A  11
CYH A   8
CYH A  43
1.05A11.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		Moxifloxacin1yo4 HYPOTHETICAL PROTEIN
X4
(SARSr-CoV)		4 / 6
ARG A  57
GLY A  -2
THR A  59
GLU A   1
1.52A12.21
15.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_B_IMNB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		Indomethacin1yo4 HYPOTHETICAL PROTEIN
X4
(SARSr-CoV)		5 / 11
GLY A  55
CYH A  52
ARG A  57
ALA A  49
LEU A   2
1.67A15.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_A_SAMA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		S-Adenosylmethionine1yo4 HYPOTHETICAL PROTEIN
X4
(SARSr-CoV)		5 / 12
ALA A  40
HIS A  58
TYR A  60
CYH A  52
CYH A  20
1.58A14.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FL5_F_RBFF204_1
(IMMUNOGLOBULIN IGG1
LAMBDA LIGHT CHAIN
IMMUNOGLOBULIN IGG1
HEAVY CHAIN)		Riboflavin1yo4 HYPOTHETICAL PROTEIN
X4
(SARSr-CoV)		4 / 8
TYR A  60
GLU A  18
PHE A  50
TYR A  25
1.68A18.18
20.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_E_TRPE81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		L-Tryptophan1yo4 HYPOTHETICAL PROTEIN
X4
(SARSr-CoV)		4 / 6
SER A  29
GLY A  11
THR A  46
THR A  44
1.40A19.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_B_ACTB207_0
(DUF1778
DOMAIN-CONTAINING
PROTEIN
N-ACETYLTRANSFERASE)		Acetic acid1yo4 HYPOTHETICAL PROTEIN
X4
(SARSr-CoV)		4 / 6
LEU A  62
THR A  44
CYH A   8
GLY A  11
1.41A18.08
19.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4F_A_ASRA141_0
(LYSOZYME C)		Arsanilic acid1yo4 HYPOTHETICAL PROTEIN
X4
(SARSr-CoV)		4 / 6
ASP A  54
GLY A  55
THR A  56
PRO A  -1
1.64A22.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_C_IPHC101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		Phenol1yo4 HYPOTHETICAL PROTEIN
X4
(SARSr-CoV)		4 / 6
CYH A   8
LEU A  62
HIS A   4
LEU A  16
1.59A14.94
17.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_D_DMED999_1
(ACETYLCHOLINESTERASE)		Decamethonium1yo4 HYPOTHETICAL PROTEIN
X4
(SARSr-CoV)		4 / 8
GLY A  27
TYR A  25
TYR A  60
HIS A  47
1.56A8.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_0
(SAM DEPENDENT
METHYLTRANSFERASE)		S-Adenosylmethionine1yo4 HYPOTHETICAL PROTEIN
X4
(SARSr-CoV)		5 / 12
TYR A   3
ALA A  51
ALA A  49
GLY A  -2
GLY A  55
1.50A14.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8I_C_FK5C201_1
(SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		Tacrolimus1yo4 HYPOTHETICAL PROTEIN
X4
(SARSr-CoV)		4 / 6
LEU A  62
SER A  29
PRO A  30
PHE A  31
1.50A12.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CCQ_A_ACTA1317_0
(THIOREDOXIN
REDUCTASE)		Acetic acid1yo4 HYPOTHETICAL PROTEIN
X4
(SARSr-CoV)		3 / 3
LEU A  62
GLU A   7
SER A  45
1.57A11.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA705_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		Citalopram1yo4 HYPOTHETICAL PROTEIN
X4
(SARSr-CoV)		5 / 9
GLN A  80
GLU A  76
LEU A  71
ILE A  73
PHE A  72
1.46A9.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PO7_A_ZONA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		Zonisamide1yo4 HYPOTHETICAL PROTEIN
X4
(SARSr-CoV)		4 / 8
TYR A  60
LEU A  41
PHE A  39
TYR A  25
1.36A11.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_G_TRPG81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		L-Tryptophan1yo4 HYPOTHETICAL PROTEIN
X4
(SARSr-CoV)		4 / 7
SER A  29
GLY A  11
THR A  46
THR A  44
1.37A19.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CPR_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		S-Adenosylmethionine1yo4 HYPOTHETICAL PROTEIN
X4
(SARSr-CoV)		5 / 12
ALA A  40
HIS A  58
TYR A  60
CYH A  52
CYH A  20
1.53A14.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3H_A_HQEA303_1
(CARBONIC ANHYDRASE 2)		Hydroquinone1yo4 HYPOTHETICAL PROTEIN
X4
(SARSr-CoV)		5 / 10
LEU A  16
LEU A  62
THR A  44
THR A  46
VAL A  14
1.46A16.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_A_AICA5001_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		Ampicillin1yo4 HYPOTHETICAL PROTEIN
X4
(SARSr-CoV)		4 / 8
ARG A  63
GLU A  77
GLN A  79
SER A  66
1.48A9.73
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_A_SAMA105_0
(PROTEIN (MET
REPRESSOR))		S-Adenosylmethionine1yo4 HYPOTHETICAL PROTEIN
X4
(SARSr-CoV)		4 / 8
PHE A  50
ARG A  57
GLU A   1
HIS A   4
1.54A24.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AWU_A_4CHA503_0
(OXIDOREDUCTASE,
FMN-BINDING)		Parachlorophenol1yo4 HYPOTHETICAL PROTEIN
X4
(SARSr-CoV)		4 / 6
SER A  29
PHE A  31
PHE A  39
PHE A  48
1.62A11.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		Vorinostat1yo4 HYPOTHETICAL PROTEIN
X4
(SARSr-CoV)		4 / 8
HIS A  58
PHE A  50
ASP A  54
GLY A  55
1.27A12.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA817_0
(GEPHYRIN)		Acetic acid1yo4 HYPOTHETICAL PROTEIN
X4
(SARSr-CoV)		3 / 3
THR A  13
ALA A  40
LYS A  38
1.66A12.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		Acetylcholine1yo4 HYPOTHETICAL PROTEIN
X4
(SARSr-CoV)		4 / 8
THR A  46
GLN A  61
TYR A   5
CYH A  43
1.50A18.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L3G_F_ACTF401_0
(METHYLAMINE
DEHYDROGENASE HEAVY
CHAIN)		Acetic acid1yo4 HYPOTHETICAL PROTEIN
X4
(SARSr-CoV)		3 / 3
ARG A  63
LEU A  82
GLU A  81
1.78A13.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_A_SAMA402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		S-Adenosylmethionine1yo4 HYPOTHETICAL PROTEIN
X4
(SARSr-CoV)		5 / 12
ALA A  40
HIS A  58
TYR A  60
CYH A  52
CYH A  20
1.51A14.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		Ketoconazole1yo4 HYPOTHETICAL PROTEIN
X4
(SARSr-CoV)		5 / 12
SER A  29
LEU A  16
ALA A  49
THR A  59
ARG A  63
1.60A10.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_2
(PROGESTERONE
RECEPTOR)		Mifepristone1yo4 HYPOTHETICAL PROTEIN
X4
(SARSr-CoV)		4 / 7
LEU A  62
GLU A  77
LEU A  82
TYR A  60
1.70A13.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQ4_A_SAMA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H2)		S-Adenosylmethionine1yo4 HYPOTHETICAL PROTEIN
X4
(SARSr-CoV)		5 / 12
GLU A  26
GLY A  27
HIS A  58
CYH A  52
CYH A  20
1.78A17.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		Mannitol1yo4 HYPOTHETICAL PROTEIN
X4
(SARSr-CoV)		4 / 8
SER A  29
GLN A  61
PHE A  48
ASN A  28
1.66A12.20
None