SIMILAR PATTERN OF AMINO ACIDS MAPPED TO UNIPROT ID 'K9N7C7'

DrReposER ID / Desc. Drug Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C9J_B_308B101_1
(PROTON CHANNEL
PROTEIN M2,
TRANSMEMBRANE
SEGMENT)		Amantadine5ko3 ORF1A
(MERS-CoV)		4 / 6
ALA A 166
SER A 167
ALA A 115
SER A 247
1.33A8.11
None
None
CME  A 111 ( 3.9A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN)		Cholic Acid5ko3 ORF1A
(MERS-CoV)		5 / 11
ILE A 289
THR A 257
LEU A 284
VAL A 268
PHE A 263
1.34A21.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)		Ribavirin5ko3 ORF1A
(MERS-CoV)		3 / 3
THR A 172
HIS A  81
LEU A  86
1.15A22.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		Cholic Acid5ko3 ORF1A
(MERS-CoV)		4 / 8
LEU A 201
LEU A 244
VAL A 212
GLY A 211
0.99A22.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRB_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		Trimethoprim5ko3 ORF1A
(MERS-CoV)		5 / 11
LEU A 133
LEU A 169
VAL A 173
ILE A 117
PHE A 148
1.19A19.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_F_DVAF2_0
(7-AMINO-ACTINOMYCIN
D)		L-Valine5ko3 ORF1A
(MERS-CoV)		3 / 3
THR A 259
PRO A 261
THR A 257
1.10A5.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3U_B_SVRB102_1
(CHROMOBOX PROTEIN
HOMOLOG 7)		Suramin5ko3 ORF1A
(MERS-CoV)		3 / 3
LYS A 112
ARG A 102
VAL A  96
1.41A14.29
CME  A 111 ( 2.9A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HIV_D_DVAD2_0
(ACTINOMYCIN D)		L-Valine5ko3 ORF1A
(MERS-CoV)		3 / 3
THR A 308
PRO A 250
THR A 249
1.25A5.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HIV_D_DVAD2_0
(ACTINOMYCIN D)		L-Valine5ko3 ORF1A
(MERS-CoV)		3 / 3
THR A 259
PRO A 261
THR A 257
1.04A5.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZV_A_ECNA411_1
(FLAVOHEMOGLOBIN)		Econazole5ko3 ORF1A
(MERS-CoV)		4 / 8
ALA A 166
LEU A 170
LEU A 123
ILE A 126
1.20A23.18
None
None
None
ACT  A 407 (-4.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_1
(DIHYDROPTEROATE
SYNTHASE DHPS)		Levomefolic acid5ko3 ORF1A
(MERS-CoV)		3 / 3
LYS A  87
ASN A 110
ASP A 147
0.91A20.72
ACT  A 402 (-2.6A)
CME  A 111 ( 4.1A)
ACT  A 405 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_B_TOPB200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		Trimethoprim5ko3 ORF1A
(MERS-CoV)		5 / 12
ASN A 110
LEU A 169
VAL A 173
ILE A 117
PHE A 148
1.24A20.45
CME  A 111 ( 4.1A)
None
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_C_CHDC401_0
(BILE SALT HYDROLASE)		Cholic Acid5ko3 ORF1A
(MERS-CoV)		4 / 8
TYR A  84
PHE A 148
LEU A 133
ALA A 132
1.43A20.49
ACT  A 402 (-4.4A)
None
None
ACT  A 405 (-3.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LZR_A_LOCA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		Colchicine5ko3 ORF1A
(MERS-CoV)		4 / 8
LEU A 245
LEU A 311
ASP A 125
ILE A 126
0.92A18.60
None
None
ACT  A 407 (-4.8A)
ACT  A 407 (-4.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD9_A_ADNA501_2
(NUPC FAMILY PROTEIN)		Adenosine5ko3 ORF1A
(MERS-CoV)		3 / 3
THR A 296
ASN A 267
PHE A 266
1.43A20.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4Y_A_TPVA501_2
(PROTEIN (HIV-1
PROTEASE))		Tipranavir5ko3 ORF1A
(MERS-CoV)		4 / 8
LEU A 123
ALA A 177
ILE A 152
ILE A 126
0.82A16.67
None
None
None
ACT  A 407 (-4.3A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YVN_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		Acetic acid5ko3 ORF1A
(MERS-CoV)		4 / 6
LEU A 133
LYS A 176
LEU A 174
LEU A 120
1.46A20.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_4
(PROTEASE RETROPEPSIN)		Nelfinavir5ko3 ORF1A
(MERS-CoV)		3 / 3
ASP A 293
THR A 308
PRO A 250
1.22A16.96
ACT  A 406 (-3.4A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD9_A_ADNA501_2
(NUPC FAMILY PROTEIN)		Adenosine5ko3 ORF1A
(MERS-CoV)		3 / 3
THR A 308
ASN A 114
PHE A 292
1.19A20.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_1
(N-METHYLTRANSFERASE)		S-Adenosylmethionine5ko3 ORF1A
(MERS-CoV)		3 / 3
TYR A  72
TYR A  84
GLU A  64
1.15A24.20
None
ACT  A 402 (-4.4A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IOM_A_FOLA608_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		Folic Acid5ko3 ORF1A
(MERS-CoV)		4 / 7
ALA A 136
LEU A 133
TYR A 155
LEU A 151
1.48A18.44
ACT  A 405 ( 3.6A)
None
None
ACT  A 405 ( 4.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9H_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE)		Trimethoprim5ko3 ORF1A
(MERS-CoV)		6 / 10
LEU A 133
ALA A 154
LEU A 169
VAL A 173
ILE A 117
PHE A 148
1.32A19.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_2
(ANGIOTENSIN
CONVERTING ENZYME)		Lisinopril5ko3 ORF1A
(MERS-CoV)		3 / 3
SER A 167
THR A 172
PHE A 148
1.13A18.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		Cholic Acid5ko3 ORF1A
(MERS-CoV)		4 / 8
MET A 185
LEU A 236
LEU A 246
GLY A 314
1.07A22.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_F_DVAF8_0
(7-AMINO-ACTINOMYCIN
D)		L-Valine5ko3 ORF1A
(MERS-CoV)		3 / 3
THR A 257
THR A 259
PRO A 261
1.24A5.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IE8_A_CHDA201_0
(REGULATORY PROTEIN)		Cholic Acid5ko3 ORF1A
(MERS-CoV)		5 / 12
LEU A  71
TYR A  72
ALA A 136
ASP A 147
LEU A 151
1.41A19.92
None
None
ACT  A 405 ( 3.6A)
ACT  A 405 (-3.5A)
ACT  A 405 ( 4.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_1
(CYTOCHROME P450 3A4)		Ritonavir5ko3 ORF1A
(MERS-CoV)		5 / 12
LEU A 170
ILE A 126
ALA A 177
ILE A 130
ALA A 132
1.29A18.18
None
ACT  A 407 (-4.3A)
None
None
ACT  A 405 (-3.2A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA153_1
(CALMODULIN)		Trifluoperazine5ko3 ORF1A
(MERS-CoV)		4 / 8
ILE A 117
LEU A 113
MET A 153
ILE A 152
1.06A19.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCP_A_BRLA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		Rosiglitazone5ko3 ORF1A
(MERS-CoV)		5 / 12
HIS A 171
LEU A 169
ILE A 149
LEU A 204
LEU A 245
1.48A22.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS1_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		Voriconazole5ko3 ORF1A
(MERS-CoV)		4 / 8
PHE A 148
ILE A 117
PHE A 128
LEU A 245
1.03A18.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OCU_A_TYLA3001_1
(LACTOTRANSFERRIN)		Acetaminophen5ko3 ORF1A
(MERS-CoV)		3 / 3
LEU A 113
TYR A 112
GLY A 277
0.77A20.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		Colchicine5ko3 ORF1A
(MERS-CoV)		4 / 4
ASN A 267
SER A 103
ALA A 115
VAL A 116
1.45A21.68
None
None
CME  A 111 ( 3.9A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUM_A_Z80A201_1
(BETA-LACTOGLOBULIN)		Chlorpromazine5ko3 ORF1A
(MERS-CoV)		4 / 8
ILE A 289
LEU A 284
ASN A 267
SER A 247
1.28A20.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YVN_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		Acetic acid5ko3 ORF1A
(MERS-CoV)		4 / 6
LEU A 244
GLN A 315
LEU A 236
LEU A 218
1.42A20.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO5_A_CHDA131_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		Cholic Acid5ko3 ORF1A
(MERS-CoV)		5 / 12
ILE A 289
THR A 257
LEU A 284
VAL A 268
PHE A 263
1.39A21.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OCU_A_TYLA3001_1
(LACTOTRANSFERRIN)		Acetaminophen5ko3 ORF1A
(MERS-CoV)		3 / 3
LEU A 169
TYR A 112
GLY A 277
1.31A20.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		Gefitinib5ko3 ORF1A
(MERS-CoV)		5 / 12
LEU A 120
VAL A 116
THR A 172
LEU A 174
LEU A 133
1.27A22.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9G_A_TOPA1159_1
(DIHYDROFOLATE
REDUCTASE)		Trimethoprim5ko3 ORF1A
(MERS-CoV)		5 / 10
LEU A 133
LEU A 169
VAL A 173
ILE A 117
PHE A 148
1.22A19.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		Mefenamic acid5ko3 ORF1A
(MERS-CoV)		3 / 3
PRO A 163
TYR A 112
GLY A 277
1.15A21.59
None