SIMILAR PATTERN OF AMINO ACIDS MAPPED TO UNIPROT ID 'K9N638'

DrReposER ID / Desc. Drug Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_A_MMSA511_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		Mimosine5dus ORF1A
(MERS-CoV)		4 / 7
HIS A  92
ASN A  35
LEU A  33
SER A  55
1.22A17.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOF_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		Amphetamine5dus ORF1A
(MERS-CoV)		4 / 5
ASP A  20
GLY A  46
ALA A  54
ILE A  22
1.02A20.11
APR  A 201 (-3.5A)
APR  A 201 (-3.3A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QKN_A_JMSA602_1
(ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE FTO)		Meclofenamic acid5dus ORF1A
(MERS-CoV)		4 / 8
LEU A  33
THR A 122
PRO A 123
VAL A 125
1.21A16.04
None
None
APR  A 201 (-4.9A)
APR  A 201 ( 4.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_A_FLPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		Flurbiprofen5dus ORF1A
(MERS-CoV)		5 / 12
VAL A 158
LEU A 162
GLY A 128
ALA A 127
LEU A 124
0.91A15.34
None
None
APR  A 201 (-3.3A)
APR  A 201 (-3.9A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAT_A_BEZA1000_0
(BENZOATE-COENZYME A
LIGASE)		Benzoic Acid5dus ORF1A
(MERS-CoV)		4 / 7
ALA A  50
GLY A  49
ILE A  47
ILE A  22
1.43A16.96
APR  A 201 ( 4.8A)
None
APR  A 201 (-4.0A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZV_A_017A200_1
(HIV-1 PROTEASE)		Darunavir5dus ORF1A
(MERS-CoV)		5 / 10
LEU A 124
ALA A  36
ILE A  51
GLY A  46
VAL A 153
1.40A20.56
None
APR  A 201 (-3.3A)
None
APR  A 201 (-3.3A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UIV_H_308H1008_1
(SERUM ALBUMIN)		Amantadine5dus ORF1A
(MERS-CoV)		4 / 6
LEU A  41
ILE A  90
ILE A  51
ALA A  48
1.34A15.56
None
None
None
APR  A 201 ( 3.7A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA153_1
(CALMODULIN)		Trifluoperazine5dus ORF1A
(MERS-CoV)		4 / 8
ILE A 142
GLU A 144
ALA A 145
VAL A  14
1.11A19.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_1
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		Suramin5dus ORF1A
(MERS-CoV)		5 / 12
ALA A  37
ALA A  87
ALA A  25
ILE A  47
LEU A 141
1.39A20.51
None
None
None
APR  A 201 (-4.0A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OCU_A_TYLA3001_1
(LACTOTRANSFERRIN)		Acetaminophen5dus ORF1A
(MERS-CoV)		3 / 3
LEU A 150
TYR A  28
GLY A  29
0.87A19.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		Flurbiprofen5dus ORF1A
(MERS-CoV)		5 / 12
VAL A 158
LEU A 162
GLY A 128
ALA A 127
LEU A 124
0.85A15.58
None
None
APR  A 201 (-3.3A)
APR  A 201 (-3.9A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_A_NPSA5_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)		Naproxen5dus ORF1A
(MERS-CoV)		5 / 12
VAL A 158
LEU A 162
GLY A 128
ALA A 127
LEU A 124
0.88A15.79
None
None
APR  A 201 (-3.3A)
APR  A 201 (-3.9A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		Adenosine5dus ORF1A
(MERS-CoV)		4 / 7
GLU A  12
THR A  11
THR A 122
ASN A 115
1.18A18.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBK_A_RAPA225_1
(FKBP25)		Sirolimus5dus ORF1A
(MERS-CoV)		5 / 12
TYR A 111
GLY A  19
VAL A 152
ILE A  16
ALA A 135
1.49A23.78
None
None
APR  A 201 (-4.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBK_A_RAPA225_1
(FKBP25)		Sirolimus5dus ORF1A
(MERS-CoV)		5 / 12
GLY A  19
VAL A  17
ILE A  16
ALA A 145
ILE A 142
1.16A23.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UYQ_A_SAMA1311_0
(HYPOTHETICAL PROTEIN
ML2640)		S-Adenosylmethionine5dus ORF1A
(MERS-CoV)		4 / 7
ALA A  21
GLY A  19
VAL A  17
LEU A  33
1.30A20.65
APR  A 201 (-3.5A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOI_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		Amphetamine5dus ORF1A
(MERS-CoV)		4 / 5
ASP A  20
GLY A  46
PRO A 123
VAL A 152
1.29A17.42
APR  A 201 (-3.5A)
APR  A 201 (-3.3A)
APR  A 201 (-4.9A)
APR  A 201 (-4.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_A_CELA682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		Celecoxib5dus ORF1A
(MERS-CoV)		5 / 12
VAL A 158
LEU A 162
GLY A 128
ALA A 127
LEU A 124
0.93A15.79
None
None
APR  A 201 (-3.3A)
APR  A 201 (-3.9A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_B_CELB682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		Celecoxib5dus ORF1A
(MERS-CoV)		5 / 12
VAL A 158
LEU A 162
GLY A 128
ALA A 127
LEU A 124
0.91A15.79
None
None
APR  A 201 (-3.3A)
APR  A 201 (-3.9A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_A_FLPA1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		Flurbiprofen5dus ORF1A
(MERS-CoV)		5 / 12
VAL A 158
LEU A 162
GLY A 128
ALA A 127
LEU A 124
0.90A15.58
None
None
APR  A 201 (-3.3A)
APR  A 201 (-3.9A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		Amphetamine5dus ORF1A
(MERS-CoV)		4 / 5
ASP A  20
GLY A  46
ALA A  54
ILE A  22
1.06A20.11
APR  A 201 (-3.5A)
APR  A 201 (-3.3A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUM_A_Z80A201_1
(BETA-LACTOGLOBULIN)		Chlorpromazine5dus ORF1A
(MERS-CoV)		4 / 8
ILE A  22
LEU A  86
ILE A  51
ILE A  47
1.42A23.81
None
None
None
APR  A 201 (-4.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		Ponatinib5dus ORF1A
(MERS-CoV)		4 / 5
VAL A 149
ILE A  51
TYR A  28
ILE A  47
1.44A19.22
None
None
None
APR  A 201 (-4.0A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_A_VD3A701_2
(CYTOCHROME P450 2R1)		Cholecalciferol5dus ORF1A
(MERS-CoV)		3 / 3
MET A 114
VAL A  14
GLU A 144
0.89A14.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		Itraconazole5dus ORF1A
(MERS-CoV)		3 / 3
ALA A  25
TYR A  28
PRO A 118
1.00A15.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_A_CELA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		Celecoxib5dus ORF1A
(MERS-CoV)		5 / 12
VAL A 158
LEU A 162
GLY A 128
ALA A 127
LEU A 124
0.91A15.34
None
None
APR  A 201 (-3.3A)
APR  A 201 (-3.9A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_A_BRLA1_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		Rosiglitazone5dus ORF1A
(MERS-CoV)		3 / 3
ILE A  22
ILE A  90
LEU A   2
0.57A21.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQH_A_FLPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		Flurbiprofen5dus ORF1A
(MERS-CoV)		5 / 12
VAL A 158
LEU A 162
GLY A 128
ALA A 127
LEU A 124
0.86A14.68
None
None
APR  A 201 (-3.3A)
APR  A 201 (-3.9A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTV_A_TESA500_1
(17
BETA-HYDROXYSTEROID
DEHYDROGENASE TYPE 1)		Testosterone5dus ORF1A
(MERS-CoV)		4 / 8
VAL A 120
LEU A  91
PRO A 123
VAL A 125
1.46A19.10
None
None
APR  A 201 (-4.9A)
APR  A 201 ( 4.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJO_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P)		Etacrynic acid5dus ORF1A
(MERS-CoV)		4 / 8
VAL A 153
VAL A  24
ILE A  10
VAL A  14
1.48A23.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D41_A_FCNA4001_1
(FOMA PROTEIN)		Fosfomycin5dus ORF1A
(MERS-CoV)		4 / 8
GLY A  44
GLY A  49
HIS A  43
ILE A  51
0.86A20.70
APR  A 201 (-3.6A)
None
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDR_A_MTXA170_2
(TELLUROMETHIONYL
DIHYDROFOLATE
REDUCTASE)		Methotrexate5dus ORF1A
(MERS-CoV)		3 / 3
SER A 161
ILE A  10
THR A 122
1.10A16.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_3
(PROTEASE)		Darunavir5dus ORF1A
(MERS-CoV)		3 / 3
ASP A  97
VAL A 132
LEU A 107
0.74A18.60
GOL  A 205 (-3.2A)
None
None