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SIMILAR PATTERN OF AMINO ACIDS MAPPED TO UNIPROT ID 'K9N5Q8'
| DrReposER ID / Desc. | Drug | Hit PDBID |
Hit Macromolecule |
Res. Matches |
View | Interface | RMSD | Seq. Identity (%) |
HETATM | Dock | |
|---|---|---|---|---|---|---|---|---|---|---|---|
 Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1RE7_A_FOLA161_0 (DIHYDROFOLATEREDUCTASE) | Folic Acid | 5x4r | S PROTEIN (MERS-CoV) | 5 / 12 | ILE A 295ALA A 103THR A 206ILE A 296TYR A 87 | 1.44A | 16.62 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1RD7_A_FOLA161_0 (DIHYDROFOLATEREDUCTASE) | Folic Acid | 5x4r | S PROTEIN (MERS-CoV) | 5 / 12 | ILE A 295ALA A 103THR A 206ILE A 296TYR A 87 | 1.41A | 16.62 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2RLC_A_GLYA333_0 (CHOLOYLGLYCINEHYDROLASE) | Glycine | 5x4r | S PROTEIN (MERS-CoV) | 3 / 3 | ASN A 220ASN A 222ARG A 181 | 1.29A | 21.49 | NoneNAG C 1 ( 1.9A)NAG C 1 ( 3.8A) | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3EKX_B_1UNB201_2 (PROTEASE) | Nelfinavir | 5x4r | S PROTEIN (MERS-CoV) | 5 / 11 | ALA A 53ASP A 54ILE A 48ILE A 337ILE A 56 | 0.98A | 13.90 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2QHF_A_ACTA502_0 (CHORISMATE SYNTHASE) | Acetic acid | 5x4r | S PROTEIN (MERS-CoV) | 3 / 3 | GLY A 340ASP A 338SER A 345 | 0.76A | 21.96 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5UXD_A_ZITA501_1 (MACROLIDE2'-PHOSPHOTRANSFERASE MPHH) | Azithromycin | 5x4r | S PROTEIN (MERS-CoV) | 4 / 7 | TYR A 77ALA A 113GLY A 115TYR A 293 | 1.48A | 19.10 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3UJ7_A_SAMA301_0 (PHOSPHOETHANOLAMINEN-METHYLTRANSFERASE) | S-Adenosylmethionine | 5x4r | S PROTEIN (MERS-CoV) | 5 / 12 | ILE A 300GLY A 177ILE A 143ILE A 245ASP A 213 | 1.40A | 21.55 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6I0Y_A_TRPA3001_0 (23S RIBOSOMAL RNATRYPTOPHANASE OPERONLEADER PEPTIDE) | L-Tryptophan | 5x4r | S PROTEIN (MERS-CoV) | 3 / 3 | TRP A 253ILE A 56ASP A 54 | 1.30A | 4.68 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2W3M_A_FOLA1188_0 (DIHYDROFOLATEREDUCTASE) | Folic Acid | 5x4r | S PROTEIN (MERS-CoV) | 5 / 12 | ILE A 296LEU A 180ILE A 256LEU A 149TYR A 87 | 1.20A | 19.47 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4G0U_B_ASWB1301_1 (DNA TOPOISOMERASE2-BETA) | Amsacrine | 5x4r | S PROTEIN (MERS-CoV) | 4 / 7 | ILE A 48PRO A 76GLY A 255GLN A 60 | 1.42A | 17.76 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ZXW_W_CHDW1060_0 (CYTOCHROME C OXIDASEPOLYPEPTIDE 7A1CYTOCHROME C OXIDASESUBUNIT 1) | Cholic Acid | 5x4r | S PROTEIN (MERS-CoV) | 4 / 7 | ILE A 250LEU A 273TYR A 144THR A 178 | 1.03A | 19.899.65 | NAG B 1 ( 4.3A)NoneNoneNone | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1CD2_A_FOLA307_0 (DIHYDROFOLATEREDUCTASE) | Folic Acid | 5x4r | S PROTEIN (MERS-CoV) | 5 / 12 | ILE A 295ALA A 103THR A 206ILE A 296TYR A 87 | 1.49A | 18.37 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6BQ4_A_ADNA401_1 (THERMOSPERMINESYNTHASE ACAULISPROTEIN) | Adenosine | 5x4r | S PROTEIN (MERS-CoV) | 5 / 12 | GLN A 319GLY A 82ASP A 80ILE A 48ASP A 54 | 1.31A | 20.44 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3FOF_F_MFXF0_1 (DNA TOPOISOMERASE 4SUBUNIT A) | Moxifloxacin | 5x4r | S PROTEIN (MERS-CoV) | 2 / 3 | GLY A 150SER A 152 | 0.14A | 21.64 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1JTV_A_TESA500_1 (17BETA-HYDROXYSTEROIDDEHYDROGENASE TYPE 1) | Testosterone | 5x4r | S PROTEIN (MERS-CoV) | 4 / 8 | VAL A 263LEU A 265PRO A 285TYR A 243 | 0.92A | 20.44 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4WQ4_B_ACTB403_0 (TRNA N6-ADENOSINETHREONYLCARBAMOYLTRANSFERASE) | Acetic acid | 5x4r | S PROTEIN (MERS-CoV) | 3 / 3 | ARG A 334ASP A 326ARG A 335 | 1.41A | 22.25 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3IHZ_A_FK5A501_2 (70 KDAPEPTIDYLPROLYLISOMERASE, PUTATIVE) | Tacrolimus | 5x4r | S PROTEIN (MERS-CoV) | 4 / 8 | TYR A 270TYR A 144GLY A 121ILE A 120 | 1.28A | 14.37 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4OAD_A_CLMA206_0 (GNAT SUPERFAMILYACETYLTRANSFERASEPA4794) | Chloramphenicol | 5x4r | S PROTEIN (MERS-CoV) | 4 / 4 | ALA A 312ALA A 311ALA A 123ALA A 124 | 1.10A | 20.18 | NoneNoneNoneNAG B 1 ( 3.9A) | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ZMA_A_ACAA501_1 (6-AMINOHEXANOATE-DIMER HYDROLASE) | Aminocaproic Acid | 5x4r | S PROTEIN (MERS-CoV) | 4 / 8 | ALA A 311ILE A 120ILE A 143TYR A 144 | 1.38A | 21.58 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5Z6M_A_FOLA201_0 (DIHYDROFOLATEREDUCTASE) | Folic Acid | 5x4r | S PROTEIN (MERS-CoV) | 5 / 11 | ILE A 296ASP A 174LEU A 225PHE A 228LEU A 187 | 1.26A | 17.11 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1TDR_A_MTXA170_2 (TELLUROMETHIONYLDIHYDROFOLATEREDUCTASE) | Methotrexate | 5x4r | S PROTEIN (MERS-CoV) | 3 / 3 | SER A 302ILE A 131THR A 127 | 1.45A | 16.62 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1YC2_E_NCAE507_0 (NAD-DEPENDENTDEACETYLASE 2) | Nicotinamide | 5x4r | S PROTEIN (MERS-CoV) | 4 / 7 | PHE A 323LEU A 325ILE A 48ASP A 49 | 1.43A | 20.35 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4OAD_A_CLMA206_0 (GNAT SUPERFAMILYACETYLTRANSFERASEPA4794) | Chloramphenicol | 5x4r | S PROTEIN (MERS-CoV) | 4 / 4 | ALA A 124ALA A 123ALA A 311ALA A 312 | 1.32A | 20.18 | NAG B 1 ( 3.9A)NoneNoneNone | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ZZB_C_ACTC401_0 (PROTON-GATED IONCHANNEL) | Acetic acid | 5x4r | S PROTEIN (MERS-CoV) | 4 / 7 | ILE A 256PHE A 116VAL A 263ILE A 290 | 1.47A | 20.34 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5WZ1_C_SAMC601_0 (NS5METHYLTRANSFERASE) | S-Adenosylmethionine | 5x4r | S PROTEIN (MERS-CoV) | 5 / 12 | GLY A 150GLY A 154THR A 168VAL A 286ILE A 290 | 1.34A | 21.47 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3UA5_A_06XA501_1 (CYTOCHROME P450 2B6) | Amlodipine | 5x4r | S PROTEIN (MERS-CoV) | 4 / 8 | ILE A 256PHE A 116GLU A 252LEU A 180 | 1.32A | 21.81 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1NW5_A_SAMA401_1 (MODIFICATIONMETHYLASE RSRI) | S-Adenosylmethionine | 5x4r | S PROTEIN (MERS-CoV) | 3 / 3 | ASP A 213HIS A 298ASP A 174 | 1.50A | 22.19 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4K87_A_ADNA602_1 (PROLINE--TRNA LIGASE) | Adenosine | 5x4r | S PROTEIN (MERS-CoV) | 4 / 8 | GLN A 261GLY A 262THR A 283THR A 257 | 1.40A | 18.44 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6G9B_A_IXXA609_1 (ENVELOPEGLYCOPROTEIN,ENVELOPE GLYCOPROTEINENVELOPEGLYCOPROTEIN) | Imipramine | 5x4r | S PROTEIN (MERS-CoV) | 4 / 7 | VAL A 170LEU A 172LEU A 225LEU A 187 | 1.13A | 21.8521.35 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 7DFR_A_FOLA161_0 (DIHYDROFOLATEREDUCTASE) | Folic Acid | 5x4r | S PROTEIN (MERS-CoV) | 5 / 12 | ILE A 295ALA A 103THR A 206ILE A 296TYR A 87 | 1.45A | 16.62 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4NKX_C_STRC601_1 (STEROID17-ALPHA-HYDROXYLASE/17,20 LYASE) | Progesterone | 5x4r | S PROTEIN (MERS-CoV) | 5 / 12 | LEU A 100ALA A 89ILE A 31ALA A 92ALA A 211 | 1.36A | 18.90 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2AOF_C_FRDC305_1 (POL POLYPROTEINPEPTIDE INHIBITOR) | Amphetamine | 5x4r | S PROTEIN (MERS-CoV) | 4 / 5 | ASP A 158GLY A 162PRO A 189ALA A 197 | 1.27A | 14.84 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4LB0_B_ACTB401_0 (UNCHARACTERIZEDPROTEIN) | Acetic acid | 5x4r | S PROTEIN (MERS-CoV) | 4 / 5 | VAL A 170LEU A 234VAL A 21PHE A 183 | 1.29A | 20.70 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4KJK_A_FOLA201_0 (DIHYDROFOLATEREDUCTASE) | Folic Acid | 5x4r | S PROTEIN (MERS-CoV) | 5 / 12 | ILE A 295ALA A 103THR A 206ILE A 296TYR A 87 | 1.47A | 16.62 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3CD2_A_MTXA307_1 (DIHYDROFOLATEREDUCTASE) | Methotrexate | 5x4r | S PROTEIN (MERS-CoV) | 5 / 12 | ILE A 131ILE A 300LYS A 308PRO A 97ILE A 132 | 1.27A | 18.37 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3IB1_A_IMNA701_1 (LACTOTRANSFERRIN) | Indomethacin | 5x4r | S PROTEIN (MERS-CoV) | 4 / 4 | PRO A 134THR A 136GLY A 94THR A 95 | 1.32A | 22.14 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5KF8_A_GCSA404_1 (PREDICTEDACETYLTRANSFERASE) | Glucosamine | 5x4r | S PROTEIN (MERS-CoV) | 4 / 8 | ARG A 141GLU A 249GLY A 121TRP A 310 | 0.80A | 21.45 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2AOF_C_FRDC305_1 (POL POLYPROTEINPEPTIDE INHIBITOR) | Amphetamine | 5x4r | S PROTEIN (MERS-CoV) | 4 / 5 | ASP A 158GLY A 154PRO A 189ALA A 197 | 1.38A | 14.84 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2PGR_A_DCFA501_2 (ADENOSINE DEAMINASE) | Pentostatin | 5x4r | S PROTEIN (MERS-CoV) | 3 / 3 | LEU A 149LEU A 180PHE A 116 | 1.32A | 20.00 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4KOE_F_TR6F101_1 (DNA TOPOISOMERASE 4SUBUNIT ADNA TOPOISOMERASE 4SUBUNIT BE-SITE DNA2) | Trovafloxacin | 5x4r | S PROTEIN (MERS-CoV) | 4 / 6 | SER A 328GLY A 55ASP A 54GLY A 276 | 1.04A | 21.6421.71 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3NDX_A_RITA100_2 (PROTEASE) | Ritonavir | 5x4r | S PROTEIN (MERS-CoV) | 5 / 11 | ALA A 53ASP A 54ILE A 48ILE A 337ILE A 56 | 0.90A | 14.84 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5GS4_A_ESTA603_2 (ESTROGEN RECEPTOR) | Estradiol | 5x4r | S PROTEIN (MERS-CoV) | 4 / 6 | LEU A 172LEU A 169PHE A 183LEU A 187 | 1.07A | 19.73 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2CD2_A_FOLA307_0 (DIHYDROFOLATEREDUCTASE) | Folic Acid | 5x4r | S PROTEIN (MERS-CoV) | 5 / 12 | ILE A 295ALA A 103THR A 206ILE A 296TYR A 87 | 1.48A | 18.37 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3UJ6_A_SAMA300_0 (PHOSPHOETHANOLAMINEN-METHYLTRANSFERASE) | S-Adenosylmethionine | 5x4r | S PROTEIN (MERS-CoV) | 5 / 12 | ILE A 300GLY A 177ILE A 143ILE A 245ASP A 213 | 1.35A | 21.55 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2PRG_A_BRLA1_2 (PEROXISOMEPROLIFERATORACTIVATED RECEPTORGAMMA) | Rosiglitazone | 5x4r | S PROTEIN (MERS-CoV) | 3 / 3 | ILE A 245ILE A 120LEU A 225 | 1.49A | 21.08 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1YC2_D_NCAD510_0 (NAD-DEPENDENTDEACETYLASE 2) | Nicotinamide | 5x4r | S PROTEIN (MERS-CoV) | 4 / 5 | ALA A 336PHE A 323ILE A 48ASP A 49 | 1.37A | 20.35 | None | ||
 Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5VYH_A_FOLA409_0 (S PROTEIN) | Folic Acid | 5x4r | S PROTEIN (MERS-CoV) | 10 / 10 | TRP A 44PRO A 45ARG A 46PRO A 47HIS A 81ALA A 123GLY A 128THR A 129ILE A 140ALA A 312 | 0.39A | 98.25 | None |