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SIMILAR PATTERN OF AMINO ACIDS MAPPED TO UNIPROT ID 'K9N4V7'
| DrReposER ID / Desc. | Drug | Hit PDBID |
Hit Macromolecule |
Res. Matches |
View | Interface | RMSD | Seq. Identity (%) |
HETATM | Dock | |
|---|---|---|---|---|---|---|---|---|---|---|---|
 Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4LF7_A_PARA1817_1 (16S RRNARIBOSOMAL PROTEIN S9RIBOSOMAL PROTEINS10) | Paromomycin | 6kl2 | NUCLEOPROTEIN (MERS-CoV) | 3 / 3 | TYR B 99ARG B 138SER B 42 | 1.41A | 22.5820.51 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4MM9_A_FVXA603_1 (TRANSPORTER) | Fluvoxamine | 6kl2 | NUCLEOPROTEIN (MERS-CoV) | 5 / 11 | VAL A 116ALA A 115GLY B 76PHE B 113ASP A 118 | 1.38A | 13.79 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3UR0_B_SVRB516_1 (RNA-DEPENDENT RNAPOLYMERASE) | Suramin | 6kl2 | NUCLEOPROTEIN (MERS-CoV) | 4 / 7 | GLY C 76ALA C 75ALA C 131ASP C 130 | 1.25A | 13.44 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6HWD_B_BO2B201_0 (PROTEASOME SUBUNITBETA TYPE-1PROTEASOME SUBUNITBETA TYPE-2) | Bortezomib | 6kl2 | NUCLEOPROTEIN (MERS-CoV) | 5 / 12 | THR C 134THR A 105ALA A 109ALA C 72THR C 129 | 1.29A | 19.1521.24 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5X24_A_LSNA503_1 (CYTOCHROME P450 2C9) | Losartan | 6kl2 | NUCLEOPROTEIN (MERS-CoV) | 4 / 6 | PRO A 152GLY A 153THR A 154LYS A 155 | 0.90A | 11.72 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5X24_A_LSNA503_1 (CYTOCHROME P450 2C9) | Losartan | 6kl2 | NUCLEOPROTEIN (MERS-CoV) | 4 / 6 | PRO D 152GLY D 153THR D 154LYS D 155 | 1.04A | 11.72 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ETE_F_H3PF552_1 (GLUTAMATEDEHYDROGENASE) | Hexachlorophene | 6kl2 | NUCLEOPROTEIN (MERS-CoV) | 4 / 7 | LYS D 40HIS B 37LYS B 37TYR D 101 | 1.49A | 13.47 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2QAK_A_1UNA1001_4 (PROTEASE RETROPEPSIN) | Nelfinavir | 6kl2 | NUCLEOPROTEIN (MERS-CoV) | 3 / 3 | ASP A 130THR C 70PRO C 71 | 1.19A | 23.40 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5K4P_A_SORA611_0 (PROBABLEPHOSPHATIDYLETHANOLAMINE TRANSFERASEMCR-1) | Sorbitol | 6kl2 | NUCLEOPROTEIN (MERS-CoV) | 4 / 6 | GLY C 106THR C 105TYR C 101GLY C 136 | 1.37A | 18.93 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5K4P_A_SORA611_0 (PROBABLEPHOSPHATIDYLETHANOLAMINE TRANSFERASEMCR-1) | Sorbitol | 6kl2 | NUCLEOPROTEIN (MERS-CoV) | 4 / 6 | GLY B 106THR B 105TYR B 101GLY B 136 | 1.43A | 18.93 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5N0O_A_SAMA501_1 (PEPTIDEN-METHYLTRANSFERASE) | S-Adenosylmethionine | 6kl2 | NUCLEOPROTEIN (MERS-CoV) | 3 / 3 | ALA D 131GLN D 73THR B 134 | 1.30A | 14.72 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1X8V_A_ESLA471_1 (CYTOCHROME P450 51) | Estriol | 6kl2 | NUCLEOPROTEIN (MERS-CoV) | 4 / 8 | TYR B 102PHE B 100PHE B 113ALA B 128 | 1.43A | 15.79 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3PFG_A_SAMA264_1 (N-METHYLTRANSFERASE) | S-Adenosylmethionine | 6kl2 | NUCLEOPROTEIN (MERS-CoV) | 3 / 3 | TYR A 102TYR A 44GLU A 125 | 0.95A | 21.67 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1BU5_A_RBFA301_1 (PROTEIN (FLAVODOXIN)) | Riboflavin | 6kl2 | NUCLEOPROTEIN (MERS-CoV) | 4 / 7 | ASN A 141THR C 134GLY C 136TYR C 102 | 1.30A | 19.62 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5X24_A_LSNA503_1 (CYTOCHROME P450 2C9) | Losartan | 6kl2 | NUCLEOPROTEIN (MERS-CoV) | 4 / 6 | PRO C 152GLY C 153THR C 154LYS C 155 | 1.00A | 11.72 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2QAK_A_1UNA1001_4 (PROTEASE RETROPEPSIN) | Nelfinavir | 6kl2 | NUCLEOPROTEIN (MERS-CoV) | 3 / 3 | ASP B 130THR D 70PRO D 71 | 1.14A | 23.40 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3NXU_A_RITA600_2 (CYTOCHROME P450 3A4) | Ritonavir | 6kl2 | NUCLEOPROTEIN (MERS-CoV) | 4 / 7 | ARG D 79ILE D 120THR D 137ARG D 97 | 1.35A | 14.88 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5K4P_A_SORA611_0 (PROBABLEPHOSPHATIDYLETHANOLAMINE TRANSFERASEMCR-1) | Sorbitol | 6kl2 | NUCLEOPROTEIN (MERS-CoV) | 4 / 6 | GLY A 106THR A 105TYR A 101GLY A 136 | 1.46A | 18.93 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3Q70_A_RITA2001_2 (CANDIDAPEPSIN-2) | Ritonavir | 6kl2 | NUCLEOPROTEIN (MERS-CoV) | 4 / 6 | THR B 105ILE B 146TYR B 44THR B 103 | 1.49A | 17.54 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2PGR_A_DCFA501_2 (ADENOSINE DEAMINASE) | Pentostatin | 6kl2 | NUCLEOPROTEIN (MERS-CoV) | 3 / 3 | LEU D 156LEU D 65PHE D 57 | 0.91A | 15.14 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2BDM_A_TMIA501_1 (CYTOCHROME P450 2B4) | Bifonazole | 6kl2 | NUCLEOPROTEIN (MERS-CoV) | 4 / 7 | SER A 42PHE A 100GLY A 62THR A 154 | 1.50A | 14.60 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2RCT_A_RTLA140_1 (RETINOL-BINDINGPROTEIN II, CELLULAR) | Vitamin A | 6kl2 | NUCLEOPROTEIN (MERS-CoV) | 3 / 3 | GLN D 73THR B 40TRP D 43 | 1.47A | 16.78 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5K4P_A_SORA611_0 (PROBABLEPHOSPHATIDYLETHANOLAMINE TRANSFERASEMCR-1) | Sorbitol | 6kl2 | NUCLEOPROTEIN (MERS-CoV) | 4 / 6 | GLY D 106THR D 105TYR D 101GLY D 136 | 1.47A | 18.93 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1BU5_A_RBFA301_1 (PROTEIN (FLAVODOXIN)) | Riboflavin | 6kl2 | NUCLEOPROTEIN (MERS-CoV) | 4 / 7 | ASN B 141THR D 134GLY D 136TYR D 102 | 1.35A | 19.62 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4GRK_A_KTRA713_1 (LACTOTRANSFERRIN) | Ketorolac | 6kl2 | NUCLEOPROTEIN (MERS-CoV) | 4 / 5 | THR A 154GLY A 62VAL A 123PRO A 64 | 1.46A | 18.32 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2PGR_A_DCFA501_2 (ADENOSINE DEAMINASE) | Pentostatin | 6kl2 | NUCLEOPROTEIN (MERS-CoV) | 3 / 3 | LEU C 156LEU C 65PHE C 57 | 0.83A | 15.14 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1PBK_A_RAPA225_1 (FKBP25) | Sirolimus | 6kl2 | NUCLEOPROTEIN (MERS-CoV) | 5 / 12 | ASP D 143GLY D 104TYR D 44ALA D 145ILE D 146 | 1.49A | 24.50 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4K50_A_ACTA506_0 (RNA POLYMERASE3D-POL) | Acetic acid | 6kl2 | NUCLEOPROTEIN (MERS-CoV) | 3 / 3 | VAL A 121GLY A 119LYS A 117 | 1.01A | 14.78 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3P4W_C_DSFC320_1 (GLR4197 PROTEIN) | Desflurane | 6kl2 | NUCLEOPROTEIN (MERS-CoV) | 4 / 8 | TYR A 44PRO A 64THR A 148ILE A 162 | 1.50A | 17.70 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1YA4_A_CTXA11_1 (CES1 PROTEIN) | Tamoxifen | 6kl2 | NUCLEOPROTEIN (MERS-CoV) | 4 / 8 | GLY D 119LYS D 117LEU D 111PRO D 107 | 1.50A | 14.53 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2NMY_A_ROCA401_3 (PROTEASE) | Saquinavir | 6kl2 | NUCLEOPROTEIN (MERS-CoV) | 3 / 3 | ASP C 130GLY C 127THR C 70 | 0.91A | 24.82 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2GVC_B_MMZB501_1 (MONOOXYGENASE) | Methimazole | 6kl2 | NUCLEOPROTEIN (MERS-CoV) | 3 / 3 | ASN A 39TYR A 77SER A 42 | 1.16A | 14.70 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6N91_A_DCFA401_1 (ADENOSINE DEAMINASE) | Pentostatin | 6kl2 | NUCLEOPROTEIN (MERS-CoV) | 4 / 4 | HIS B 124LEU A 111TYR A 77GLY A 119 | 1.05A | 17.06 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2D55_C_DVAC2_0 (ACTINOMYCIN D) | L-Valine | 6kl2 | NUCLEOPROTEIN (MERS-CoV) | 3 / 3 | THR B 56PRO B 54PRO B 157 | 1.40A | 6.35 | None |