SIMILAR PATTERN OF AMINO ACIDS MAPPED TO UNIPROT ID 'F4NBU6'

DrReposER ID / Desc. Drug Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_A_GLYA715_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		Glycine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 6
GLY A 112
ASP A 102
SER A   4
ARG A   6
1.54A18.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_A_ZMRA1471_1
(NEURAMINIDASE)		Zanamivir6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		5 / 12
ARG A  97
ARG A  62
GLU C   2
GLU A 163
TYR A  99
1.68A19.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA206_1
(CARDIAC TROPONIN C)		Bepridil6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		4 / 8
MET A   5
GLU C   2
GLU A  55
ARG A  48
1.55A20.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKI_B_IMNB201_1
(TRANSTHYRETIN)		Indomethacin6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		4 / 6
LEU A 147
LEU C  10
SER A  77
THR A  73
1.23A19.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E3I_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		L-Histidine6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		5 / 12
GLU A 163
GLU A  63
TYR A  99
TYR A   7
ALA C   4
1.50A21.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFY_A_T27A601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		Rilpivirine6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
PRO A 235
VAL B  82
VAL B   9
TYR B  66
PRO B   5
1.48A19.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_A_RABA602_1
(ADENOSYLHOMOCYSTEINA
SE)		Vidarabine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
LEU A 168
LEU A 110
LEU A 109
GLY A 112
HIS A 113
1.52A20.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1479_0
(TRANSLATION
ELONGATION FACTOR
SELB)		Deoxycholic Acid6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		4 / 5
THR C   3
ILE A  66
GLU A  63
PHE A  22
1.53A2.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_C_ZMRC1470_1
(NEURAMINIDASE)		Zanamivir6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		5 / 12
ARG A  97
ARG A  62
GLU C   2
GLU A 163
TYR A  99
1.69A19.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		Sorafenib6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		5 / 12
GLU C   2
LEU A 160
TRP A 133
LEU A 168
GLY A 100
1.58A3.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_2
(CYTOCHROME P450 2C9)		Losartan6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		3 / 3
LEU A 172
VAL A 103
ASP A 102
0.94A17.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_C_EPAC502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		Icosapent6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 8
LEU B  54
PHE B  62
ARG A  21
ALA A  11
PRO B   5
1.66A12.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		Sorafenib6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		5 / 12
GLU C   2
LEU A 160
TRP A 133
LEU A 168
GLY A 100
1.62A3.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IP7_D_ADND604_1
(PYRUVATE KINASE
ISOZYMES L)		Adenosine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		3 / 3
ARG A 170
GLU A  55
ASN A 174
1.63A19.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		Salicylic acid6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 7
LEU A  81
TYR A 123
ILE A 142
GLY A  83
1.35A19.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H8T_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		Vitamin A6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
LEU A 126
LEU A 147
ALA A 153
TYR A 159
LEU A 109
1.56A19.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SAN_A_ZMRA901_1
(NEURAMINIDASE)		Zanamivir6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		5 / 12
GLU A  55
ALA C   4
GLU A 163
TYR A   7
TYR A 171
1.46A20.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_B_NPSB603_1
(SERUM ALBUMIN)		Naproxen6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		5 / 11
ARG A  97
SER A  77
VAL A 152
LEU A 147
LEU C   9
1.58A18.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TDZ_A_ADNA905_1
(ATP-CITRATE SYNTHASE)		Adenosine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 6
ARG A 239
ASP A 177
ARG A 181
LEU A 179
1.57A20.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_A_ADNA438_1
(ADENOSYLHOMOCYSTEINA
SE)		Adenosine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
LEU A 168
LEU A 110
LEU A 109
GLY A 112
HIS A 113
1.51A21.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NQA_H_9CRH501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		Alitretinoin6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
ALA A 140
ALA A 139
GLN A 141
ALA A 135
ILE B   1
0.94A22.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_1
(UNCHARACTERIZED
PROTEIN)		S-Adenosylmethionine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		3 / 3
ARG A 256
GLU A 222
TYR A 257
1.06A19.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZUC_A_T98A201_1
(PROGESTERONE
RECEPTOR)		Tanaproget6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		5 / 10
LEU C   8
ASN A  70
GLN A  72
LEU C  10
TYR A 116
1.72A5.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)		Mifepristone6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
ASN A 174
GLY A 175
PHE A  33
MET A   5
LEU A 168
1.54A21.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		Bortezomib6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 9
THR A 258
THR A 216
ALA A 245
GLY A 221
ASP A 227
1.70A19.43
20.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_C_ADNC501_2
(-)		Adenosine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 5
GLN A 242
THR A 233
THR A  31
GLY A 207
1.42A19.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		Sulfasalazine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		3 / 3
LEU A 168
MET A   5
ASP A 177
1.16A20.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_A_SAMA301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		S-Adenosylmethionine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
GLY A 112
LEU A 156
LEU A 160
TRP A 133
TYR A 116
1.32A22.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_A_FUAA1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		Fusidic Acid6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 5
ILE A  52
LYS A 176
HIS A   3
VAL A  28
1.78A13.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_D_ADND502_2
(ADENOSYLHOMOCYSTEINA
SE)		Adenosine6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		3 / 3
THR A  71
THR A  94
LEU B  54
0.70A18.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CGD_A_AKNA600_1
(BIFUNCTIONAL AAC/APH)		Amikacin6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		5 / 10
GLY A 162
TYR A 159
TYR A 171
VAL A  34
GLU C   2
1.71A19.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_B_ZMRB1002_1
(NEURAMINIDASE)		Zanamivir6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		5 / 12
ARG A  97
ARG A  62
GLU C   2
GLU A 163
TYR A  99
1.76A20.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_A_C2FA1100_0
(GLYCINE
N-METHYLTRANSFERASE)		Levomefolic acid6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 6
SER A  38
HIS A   9
THR A  71
ARG A  75
1.76A23.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		Tolfenamic Acid6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		3 / 3
LEU A 147
TYR A 116
SER A  77
0.93A18.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Z_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		Alitretinoin6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
ALA A 140
ALA A 139
GLN A 141
ALA A 135
ILE B   1
1.08A20.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_B_SAMB300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		S-Adenosylmethionine6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 5
SER A  13
GLY A  91
HIS B  84
ASP A 119
1.57A21.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_1
(HYPOTHETICAL PROTEIN
RV2118C)		S-Adenosylmethionine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		3 / 3
GLU A 264
HIS A 263
ASP A  30
1.55A22.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBY_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		Alitretinoin6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
ALA A 140
ALA A 139
GLN A 141
ALA A 135
HIS A  93
1.49A20.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_B_LOCB504_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA CHAIN)		Colchicine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		3 / 3
SER A 132
ALA A 153
VAL A 152
0.92A21.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_A_ADNA401_1
(PUTATIVE ADENOSINE
KINASE)		Adenosine6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		6 / 12
ASN A 114
LEU C   5
GLY A 100
THR C   3
LEU A 156
GLY A  26
1.54A21.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_F_MFXF2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		Moxifloxacin6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 6
ARG A 273
ARG A 219
GLY A 221
GLU A 222
1.49A20.25
21.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XO7_A_ASDA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		4-Androstenedione6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 7
TYR A  99
VAL A  34
ILE A  52
LEU A 168
1.38A20.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F32_B_ACTB602_0
(AMINE OXIDASE LKCE)		Acetic acid6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		4 / 6
ASN A 114
TYR A  99
VAL A 152
THR C   3
1.74A20.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_B_SAMB293_0
(GLYCINE
N-METHYLTRANSFERASE)		S-Adenosylmethionine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
ASN A  70
SER A  67
TYR A 159
TYR A 116
TYR A  74
1.79A22.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TH6_A_OINA401_1
(PHOSPHOLIPASE A2)		Hyoscyamine6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		4 / 7
GLY A  26
HIS A   9
TYR A  99
LYS C   1
1.38A16.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ1_G_6ELG501_0
(PROTEIN CEREBLON)		Thalidomide6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 8
HIS A 113
TRP B  60
PHE B  56
THR A 134
1.72A13.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_H_FFOH403_0
(THYMIDYLATE SYNTHASE)		Levoleucovorin6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		5 / 12
TYR A  99
LEU A 156
LEU C   9
ASN A  70
ALA A 150
1.31A24.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		Spermine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 7
GLU A  53
GLU A  55
TYR A 171
ARG A 170
1.62A19.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAQ_A_2GMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		Dihydroergotamine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 6
ILE A  23
THR A  24
SER A  38
ASP A 119
1.43A19.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OSV_B_CHCB201_2
(BILE ACID RECEPTOR)		Obeticholic acid6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 5
HIS A  93
ARG A  82
ILE A  23
HIS B  31
1.61A20.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_B_ADNB401_1
(ADENOSINE KINASE,
PUTATIVE)		Adenosine6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		7 / 12
ASN A 114
ILE A  66
LEU C   5
GLY A 100
THR C   3
LEU A 156
GLY A  26
1.74A21.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_RALB600_1
(ESTROGEN RECEPTOR)		Raloxifene6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		6 / 12
GLU A 163
LEU A 160
ARG A  62
LEU C   8
LEU A 126
LEU A 130
1.75A20.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FCN_B_DVAB35_0
(UBIQUITIN)		L-Valine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 6
LEU A 201
GLU A 198
ILE A 194
PRO A 193
1.66A13.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KT0_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		Phylloquinone6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 11
SER A  92
GLY A  91
ARG A  82
LEU A  78
ILE A  66
1.33A14.71
9.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNI_A_SAMA401_0
(NSP16 PROTEIN)		S-Adenosylmethionine6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
GLY A 237
GLY A 207
LEU A  32
ASP B  53
ASP A 238
1.69A20.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		Mercaptopurine6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 6
GLY A 237
ALA A 236
LEU B  65
PRO A 235
1.54A21.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		Colchicine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		3 / 3
SER A 132
ALA A 153
VAL A 152
0.98A21.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_K_SAMK302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		S-Adenosylmethionine6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
HIS B  31
LEU A  81
ILE A 124
SER A 143
LEU A  95
1.29A14.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF8_A_LBHA2004_1
(HDAC6 PROTEIN)		Panobinostat6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
PRO A  43
SER A  67
PHE A  36
PHE A  22
ASP A  39
1.71A20.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_B_CFFB2434_1
(CHITINASE)		Caffeine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 6
TRP A 167
GLU A 163
TYR A 159
PHE A  33
1.72A20.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_F_LFXF0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		Levofloxacin6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 5
SER B  33
ARG A  82
GLY A  91
GLU A  89
1.37A13.20
15.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3002_1
(SERUM ALBUMIN)		Levothyroxine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 8
GLN A 115
ASN A 114
LEU A 160
ARG A 111
1.34A19.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GAH_A_ACRA497_1
(GLUCOAMYLASE-471)		Acarbose6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
TYR A  59
GLY A 162
GLU A 163
TYR A   7
GLU A  63
1.57A20.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_C_9PLC1_1
(CYTOCHROME P450 2A13)		Pilocarpine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 7
PHE A  33
ALA A  49
THR A  31
LEU A 179
1.26A18.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		Calcidiol6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		3 / 3
THR A 228
LEU A 230
VAL A 231
0.88A12.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJE_A_TOYA202_1
(AADB)		Tobramycin6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		4 / 8
ASP B  53
GLU C   2
ILE A  66
TYR A  74
1.51A18.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MQT_A_STIA302_1
(DEOXYCYTIDINE KINASE)		Imatinib6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		5 / 12
ILE A  66
TYR A  99
GLU A 161
GLN A 155
GLU C   2
1.69A21.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J03_A_FVSA603_1
(BIFUNCTIONAL EPOXIDE
HYDROLASE 2)		Fulvestrant6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		5 / 12
ILE A  52
TYR A 159
LEU C   8
LEU A 156
HIS A   9
1.21A18.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2477_1
(NEURAMINIDASE)		Zanamivir6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		5 / 12
ARG A  97
ARG A  62
GLU C   2
GLU A 163
TYR A  99
1.72A19.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OA1_A_TRPA2003_0
(TRYPTOPHAN
HALOGENASE)		L-Tryptophan6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
PRO A  43
ILE A  66
PHE A  36
GLU A  63
TRP A  60
1.79A20.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_A_AM2A301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		Apramycin6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 8
ASP A 196
HIS A 191
HIS A 197
GLU A 254
1.44A21.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZK_B_T44B128_1
(TRANSTHYRETIN)		Levothyroxine6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		4 / 7
LEU A 147
LEU C  10
SER A  77
THR A  73
1.24A18.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_B_SAMB4001_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		S-Adenosylmethionine6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		5 / 12
LEU C   8
LEU C   7
ASN A  80
LEU C  10
ILE A 124
1.25A3.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_B_MTLB806_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		Mannitol6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 7
GLN A  96
PHE A   8
ASN A 114
TRP B  60
1.52A20.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_D_D16D402_1
(THYMIDYLATE SYNTHASE)		Raltitrexed6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 8
ARG A 169
TYR A 171
ILE A  52
LEU A 179
GLY A 175
1.46A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFV_A_T27A601_1
(EXORIBONUCLEASE H,
P66 RT)		Rilpivirine6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
PRO A 235
VAL B  82
VAL B   9
TYR B  66
PRO B   5
1.46A19.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRJ_A_ADNA300_1
(ALPHA-TRICHOSANTHIN)		Adenosine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 8
GLY A 175
TYR A 171
ILE A  52
GLU A  55
1.36A22.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_B_SAMB480_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		S-Adenosylmethionine6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
GLY A 237
ALA B  15
ASN B  24
LEU B  39
PHE B  70
1.63A19.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_D_MXMD606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		Meloxicam6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
ILE A 213
VAL A 261
LEU A 270
LEU A 215
LEU A 206
1.47A17.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		S-Adenosylmethionine6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		5 / 12
ILE A  52
VAL A  34
MET A   5
LEU C   5
TYR A  59
1.36A22.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y03_B_SALB801_1
(PROTEIN POLYBROMO-1)		Salicylic acid6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		4 / 5
LEU A 156
ALA C   6
ASN A  70
ILE A  66
1.46A19.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZO1_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		Liothyronine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
ILE A 124
ARG A  97
ALA A 153
LEU A 126
ASN A 114
1.58A22.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XR4_B_AG2B511_1
(HOMOSPERMIDINE
SYNTHASE)		Agmatine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		3 / 3
VAL A  34
PHE A  36
ARG A  44
1.61A21.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_1_T441128_1
(TRANSTHYRETIN)		Levothyroxine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 6
LEU A 160
GLU A 163
ALA A 158
LEU A 130
1.09A19.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_A_DVAA6_0
(MINI-GRAMICIDIN A)		L-Valine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		3 / 3
ALA A 149
VAL A 152
TRP A 133
1.31A24.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Y_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		Alitretinoin6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
ALA A 140
ALA A 139
GLN A 141
ALA A 135
ILE B   1
1.26A20.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZU_A_X89A411_1
(FLAVOHEMOPROTEIN)		Miconazole6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		6 / 12
ALA A 125
LEU A 126
HIS A   9
LEU A 160
TYR A 159
LEU C   5
1.40A18.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWR_A_ZMRA513_1
(NEURAMINIDASE)		Zanamivir6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		5 / 12
ARG A  97
ARG A  62
GLU C   2
GLU A 163
TYR A  99
1.74A20.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_1
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		S-Adenosylmethionine6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		4 / 6
TYR A   7
GLY C   1
LEU A 168
GLU A  63
1.44A19.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JQ4_B_IMNB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		Indomethacin6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		5 / 10
HIS A   9
ILE A 124
ASN A  70
LEU C   5
LEU C   8
1.60A20.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF0_A_SAMA505_0
(CARNOSINE
N-METHYLTRANSFERASE)		S-Adenosylmethionine6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
SER B  33
MET A  12
PHE A   8
PHE A  36
TYR A  27
1.76A14.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA502_1
(CYTOCHROME P450 2C9)		Losartan6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		5 / 12
ALA A  49
LEU A  32
VAL A  28
MET A   5
GLY C   1
1.49A17.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_B_ACTB401_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT
N6-ADENOSINE-METHYLT
RANSFERASE SUBUNIT
METTL14)		Acetic acid6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 6
GLU A  19
ARG A  75
LEU A  78
ARG A  79
1.27A23.45
21.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE)		Mannitol6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 8
GLN A  96
PHE A   8
ASN A 114
TRP B  60
1.58A20.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XMF_A_HSMA202_1
(NITROPHORIN-7)		Histamine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		3 / 3
ASP A 238
LEU A 206
GLY A 207
0.88A22.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1294_1
(FICOLIN-2)		Acetylcysteine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 9
GLY A 100
LEU A 126
LEU A 130
ASP A 102
GLU A 128
1.71A20.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2O_A_8N6A501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		Pioglitazone6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		5 / 12
PHE A  22
SER A  77
LEU C   7
LEU A  95
TYR A 116
1.74A21.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_A_ADNA303_1
(5'/3'-NUCLEOTIDASE
SURE)		Adenosine6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		5 / 10
ALA A 139
ILE A 124
LEU C  10
LEU A 147
TYR A 123
1.60A24.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1000_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		Isoprenaline6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 6
GLU A  55
PRO A  57
TRP A 167
GLU A  58
1.46A19.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E22_B_LOCB700_1
(TUBULIN ALPHA-1C
CHAIN
TUBULIN BETA-2B
CHAIN)		Colchicine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		3 / 3
SER A 132
ALA A 153
VAL A 152
1.16A20.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_C_HISC450_0
(HISTIDYL-TRNA
SYNTHETASE)		L-Histidine6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		5 / 12
GLU A 163
GLU A  63
TYR A  99
TYR A   7
ALA C   4
1.55A22.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		Cocaine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 8
LEU A 168
LEU A 110
SER A   2
GLU A 180
1.49A24.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDM_B_AGGB1462_1
(INTEGRIN ALPHA-IIB
INTEGRIN BETA-3)		Tirofiban6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
PHE A  22
TYR A  74
LEU A  78
TYR A   7
ASN A 114
1.63A22.80
18.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')		Cocaine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 7
TYR A  74
ARG A  97
TYR A 123
TYR A  84
TYR A  85
1.70A21.00
21.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_1
(METHYLTRANSFERASE
NSUN4)		S-Adenosylmethionine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		3 / 3
ASP A 183
ARG A 181
ASP A  30
1.39A21.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_C_ZPCC1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		Eszopiclone6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		5 / 12
GLU A  63
ILE A  66
GLU C   2
TYR A  99
VAL A 103
1.62A21.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3003_1
(SERUM ALBUMIN)		Levothyroxine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 6
ILE A 213
LYS A 243
ALA A 245
VAL A 261
1.73A19.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OHR_A_1UNA201_1
(ASPARTYLPROTEASE)		Nelfinavir6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 11
GLY B  29
ASP B  59
GLY A 120
ILE B   1
THR A  10
1.44A17.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_C_REAC503_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		Tretinoin6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 10
ALA A 140
ALA A 139
GLN A 141
ALA A 135
ILE B   1
1.05A20.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_B_ADNB438_1
(ADENOSYLHOMOCYSTEINA
SE)		Adenosine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
LEU A  78
HIS A  93
THR A  94
GLN A  96
GLY A 120
1.74A21.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_A_RTLA401_0
(RETINOL DEHYDRATASE)		Vitamin A6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		5 / 12
LEU C  10
LEU C   8
HIS B  31
TYR A 123
ILE A 124
1.51A1.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V35_A_NTIA317_1
(ALDOSE REDUCTASE)		Nitazoxanide6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 8
VAL A  28
TRP A 167
PRO A  47
TRP A  60
1.70A20.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		Eszopiclone6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 7
GLU A  63
ILE A  66
TYR A 159
VAL A 103
1.42A21.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UT5_B_LOCB502_1
(TUBULIN BETA CHAIN)		Colchicine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
ALA A 139
LEU A  81
THR A  94
ILE A 124
LYS A 121
1.55A18.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1I_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		S-Adenosylmethionine6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 7
LYS B  58
SER B  55
PHE A   8
ASP A  30
1.73A12.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA605_0
(ALPHA-AMYLASE)		Acarbose6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 8
TYR A 123
GLY A 120
ILE B   1
ASP A 122
1.43A19.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_B_9TPB601_1
(SERUM ALBUMIN)		Teniposide6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		5 / 12
LEU A  81
TYR A 116
ILE A 124
LEU C   8
LYS A 146
1.48A19.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M7T_A_SAMA503_0
(BTRN)		S-Adenosylmethionine6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		5 / 11
TYR A  27
GLU C   2
THR A  10
LEU B  54
LEU B  64
1.68A21.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_1
(TRANSTHYRETIN)		Liothyronine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 6
LEU A 160
GLU A 163
ALA A 158
LEU A 130
1.16A19.46
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WM2_A_ACTA605_0
(SALICYLATE-AMP
LIGASE)		Acetic acid6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		3 / 3
THR A 271
THR A 258
ARG A 273
1.55A20.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E7F_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		Levomefolic acid6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		5 / 12
GLU A  63
PHE A  33
ASN A  70
LEU C   8
ILE A  66
1.50A21.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_G_EVPG2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		Etoposide6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 6
SER A  88
GLY A  18
ARG A  17
GLY A  16
1.38A20.25
21.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		Methylergometrine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 11
ASP A  29
VAL A  28
LEU A 172
ALA A  49
TYR A 209
1.57A19.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EML_A_SAMA701_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		S-Adenosylmethionine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
GLY A 100
LEU A 168
ASN A 114
ARG A 157
LEU A 109
1.61A17.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKK_E_MFXE1100_1
(TOPOISOMERASE IV
DNA)		Moxifloxacin6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		3 / 3
ARG A  21
GLU C   2
SER B  33
1.41A16.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		Acetic acid6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 7
ALA A 205
ILE A 213
ARG A 234
GLY A 207
1.59A22.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_E_ASCE1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		Vitamin C6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 7
HIS A   9
ILE A  66
TYR A  99
ARG A  97
1.38A20.85
18.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KF8_A_GCSA404_1
(PREDICTED
ACETYLTRANSFERASE)		Glucosamine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 8
ARG A  82
PRO A  20
GLY A  16
PRO A  15
1.53A20.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_E_FFOE403_0
(THYMIDYLATE SYNTHASE)		Levoleucovorin6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		5 / 12
TYR A  99
LEU A 156
LEU C   9
ASN A  70
ALA A 150
1.34A24.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIY_A_B49A1_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		Sunitinib6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 11
ALA A  49
VAL A  28
PHE A  33
GLY A 175
LEU A 179
1.57A20.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_1
(VP39)		S-Adenosylmethionine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		3 / 3
ASP A 183
ARG A 181
ASP A 238
1.48A19.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UYM_B_VORB590_1
(14-ALPHA STEROL
DEMETHYLASE)		Voriconazole6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 7
TYR A  74
ALA A 117
ILE A 124
LEU A  81
1.24A20.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C8L_A_CFFA940_1
(PROTEIN (GLYCOGEN
PHOSPHORYLASE))		Caffeine6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 6
ASN B  24
PHE B  22
HIS B  13
ALA A 236
GLY A 237
1.79A7.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_B_SAMB301_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		S-Adenosylmethionine6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		4 / 7
GLY A 162
THR C   3
GLU A 166
ALA A 158
1.01A23.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		S-Adenosylmethionine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 6
HIS A 192
HIS A 188
GLU A 229
ASP A 227
1.62A24.84
None
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3VRJ_A_1KXA301_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN
10-MER PEPTIDE)		Abacavir6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		5 / 12
TYR A  74
TYR A  99
TYR A 123
ILE A 124
THR C   3
0.45A89.05
23.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZM_A_SAMA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)		S-Adenosylmethionine6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		3 / 3
ARG A 234
ASP A 238
ASN B  24
1.35A21.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5J_A_08HA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		Alprazolam6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		4 / 7
LEU C   5
LEU C   8
ASN A  70
ILE A  66
1.41A5.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XL6_B_SPMB3001_1
(INWARD RECTIFIER
POTASSIUM CHANNEL)		Spermine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 5
ALA A 140
TYR A 118
ALA A 136
GLN A  96
1.35A22.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZ2_A_212A404_1
(GERMACRADIENOL/GEOSM
IN SYNTHASE)		Alendronic acid6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		5 / 9
VAL A 152
ASN A  70
GLU C   2
ARG A  97
TYR A  74
1.66A20.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M5M_A_DX4A401_0
(2-AMINO-4-HYDROXY-6-
HYDROXYMETHYLDIHYDRO
PTERIDINE
PYROPHOSPHOKINASE)		Tioguanine6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		4 / 8
THR A  73
LEU C   8
TYR A  74
ASN A  70
1.38A22.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_1
(TUBULIN BETA CHAIN)		Paclitaxel6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
GLU A 166
LEU A 126
ALA A 158
LEU A 130
LEU A 109
1.52A19.46
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WV2_A_TPFA1_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		Fluconazole6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		5 / 9
TYR A  99
TYR A   7
ALA C   4
ALA C   6
THR A  73
1.76A19.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4477_1
(NEURAMINIDASE)		Zanamivir6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		5 / 12
ARG A  97
ARG A  62
GLU C   2
GLU A 163
TYR A  99
1.75A19.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_B_SAMB602_1
(HYPOTHETICAL PROTEIN)		S-Adenosylmethionine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		3 / 3
GLY A 175
GLU A 173
ASP A 177
1.44A21.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DF7_A_MTXA501_2
(DIHYDROFOLATE
REDUCTASE)		Methotrexate6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		3 / 3
TRP A 167
ARG A 157
THR C   3
1.26A21.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_D_ADND438_1
(ADENOSYLHOMOCYSTEINA
SE)		Adenosine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
LEU A 168
LEU A 110
LEU A 109
GLY A 112
HIS A 113
1.49A21.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NO0_A_GEOA302_1
(DEOXYCYTIDINE KINASE)		Gemcitabine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
ILE A  66
GLU A 163
MET A   5
TYR A   7
ARG A  62
1.78A20.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRQ_A_STRA501_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		Progesterone6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 11
VAL A  34
ILE A  52
GLU A 163
TRP A 167
LEU A 168
1.46A21.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_A_GMJA301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		Haloperidol6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		5 / 12
TYR A 159
PHE A  33
VAL A  28
VAL A  34
LEU C   5
1.47A24.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMS_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		Dasatinib6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 11
ILE A  52
TYR A 171
LEU A 172
LEU A 179
ASP A 177
1.62A19.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_F_TA1F502_1
(TUBULIN BETA CHAIN)		Paclitaxel6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
GLU A 166
LEU A 126
ALA A 158
LEU A 130
LEU A 109
1.52A19.46
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTD_E_GFNE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		Gatifloxacin6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 7
ALA A  11
ASP B  53
ARG A  35
GLU A  46
1.29A20.58
22.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO6_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		Cholic Acid6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		5 / 12
TYR A  85
LEU A  81
LEU C  10
ALA A 140
HIS B  31
1.44A17.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KFB_A_T27A607_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H,
EXORIBONUCLEA P66 RT)		Rilpivirine6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
PRO A 235
VAL B  82
VAL B   9
TYR B  66
PRO B   5
1.46A19.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL0_A_1UNA201_1
(PROTEASE)		Nelfinavir6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 8
ALA A  40
ASP A  39
ASP A  37
THR A  64
1.06A17.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_B_0HKB1201_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		Tiotropium6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
SER B  52
THR A 240
ALA A 236
TYR B  26
TYR B  63
1.77A12.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA303_1
(CHITOSANASE)		Glucosamine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 5
ASP A 223
HIS A 260
VAL A 247
ALA A 245
1.35A20.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_B_LEIB16_0
(COIL SER L16D-PEN)		Penicillamine6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		4 / 5
LEU C   9
GLN A  72
LEU C   7
GLU A  76
1.71A29.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6R_B_CRNB603_1
(CREATINE KINASE
B-TYPE)		Creatine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 6
THR A 190
VAL A 189
LEU A 201
GLU A 254
1.69A20.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		S-Adenosylmethionine6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
SER A  92
MET A  12
VAL B  27
ASP B  34
ILE B  35
1.69A13.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		Azithromycin6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 6
PRO B  14
GLU A 232
ALA A 245
LEU A 215
1.46A14.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V2M_A_AZMA303_1
(CARBONIC ANHYDRASE 2)		Acetazolamide6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 10
HIS A 192
VAL A 189
LEU A 201
THR A 200
TRP A 274
1.69A21.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		Grazoprevir6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		3 / 3
TYR A  27
LEU A 156
ARG A   6
1.68A22.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCP_A_BRLA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		Rosiglitazone6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		5 / 12
PHE A  22
SER A  77
LEU C   7
LEU A  95
TYR A 116
1.62A21.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_B_T44B328_1
(TRANSTHYRETIN)		Levothyroxine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 8
LEU A 272
LYS A 243
ALA A 205
THR A 187
1.06A17.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEO_A_DHIA4_0
((DPR)PY(DHI)PKDL(DGN
))		L-Histidine6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		3 / 3
TYR B  63
PRO A 235
LEU B  65
1.49A10.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_C_RBFC201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		Riboflavin6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 9
ILE A  52
GLU A  55
ASN A 174
LEU A 168
PHE A  33
1.40A18.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5S_A_ACHA1289_0
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		Acetylcholine6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		4 / 6
VAL A  34
TYR A  59
GLU C   2
ILE A  66
1.50A23.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_E_9CRE1500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		Alitretinoin6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
ILE A 124
ALA A 140
ALA A 135
GLN A 141
ARG A 145
1.49A20.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_C_ACTC502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		Acetic acid6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		3 / 3
PRO A 210
ASP A  30
GLU A 212
1.09A22.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVR_A_SALA203_1
(3-HYDROXYANTHRANILAT
E 3,4-DIOXYGENASE)		Salicylic acid6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		4 / 7
GLU C   2
HIS A   9
VAL A  34
GLU A  63
1.33A6.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_1
(CYCLIN-DEPENDENT
KINASE 8)		Sorafenib6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
ALA A 139
LEU A 147
ILE A 124
ALA A 136
LEU A 156
1.34A19.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_D_BEZD2385_0
(CES1 PROTEIN)		Benzoic Acid6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		4 / 5
LEU A 147
SER A  77
LEU C   5
LEU C   7
1.39A18.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_2
(TRANSTHYRETIN)		Levothyroxine6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		4 / 7
LEU A 147
LEU C  10
SER A  77
THR A  73
1.31A19.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_ACTA148_0
(UPF0066 PROTEIN
AF_0241)		Acetic acid6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		3 / 3
VAL A 249
GLU A 254
GLU A 253
1.61A20.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_C_ACTC36_0
(GCN4 LEUCINE ZIPPER)		Acetic acid6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 10
TYR A 118
ALA A 139
ALA A 140
SER A 143
TYR A  84
1.69A11.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1W_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		Progesterone6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 7
TYR A  99
VAL A  34
ILE A  52
LEU A 168
1.43A20.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		Salicylic acid6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 6
LEU A  81
TYR A 123
ILE A 142
GLY A  83
1.36A19.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GPG_A_RAPA301_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP3)		Sirolimus6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 11
LEU A 172
VAL A  28
TRP A  51
TYR A 209
ALA A 182
1.67A21.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1477_1
(NEURAMINIDASE)		Zanamivir6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		5 / 12
ARG A  97
ARG A  62
GLU C   2
GLU A 163
TYR A  99
1.71A19.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_NPSA603_1
(SERUM ALBUMIN)		Naproxen6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		6 / 10
ARG A 234
LEU A 206
LEU A 215
ALA A 205
LEU A 230
ALA A 245
1.68A20.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP3_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)		Tioguanine6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		4 / 6
ALA A 150
GLN A 155
LEU A 147
LEU C   5
1.64A22.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVP_B_GBMB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		Glyburide6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		5 / 12
TYR A  74
LEU C  10
ILE A 124
HIS A   9
LEU A 156
1.42A21.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		Cholic Acid6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 7
ILE A  52
GLY A 175
TYR A 209
LEU A 168
1.25A20.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		Colchicine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		3 / 3
SER A 132
ALA A 153
VAL A 152
0.86A21.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EF6_A_ACTA405_0
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		Acetic acid6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 6
THR A 138
GLN A 144
ARG A 145
ILE A 142
1.44A22.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		Moxifloxacin6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 7
ALA A  11
ASP B  53
ARG A  35
GLU A  46
1.31A20.58
22.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_B_SAMB301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		S-Adenosylmethionine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
GLY A 107
GLY A 104
SER A   2
VAL A 165
GLU A 166
1.19A21.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA444_1
(ALPHA AMYLASE)		Acarbose6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 7
TYR A  74
ASN A 114
TYR A 159
GLY A 112
1.53A22.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_1
(PROGESTERONE
RECEPTOR)		Mifepristone6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
LEU A 266
GLY A 207
GLN A 242
ARG A 234
LEU A 272
1.42A22.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LBD_A_REAA500_1
(RETINOIC ACID
RECEPTOR GAMMA)		Tretinoin6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
ARG A  14
ARG A  75
PHE A  22
SER A  38
GLY A 120
1.62A20.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_B_BEZB160_0
(HEME-BINDING PROTEIN
HUTZ)		Benzoic Acid6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 4
LEU A 109
GLY A 112
LEU A 130
GLU A 128
1.43A20.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_0
(FATTY ACID-BINDING
PROTEIN)		Cholic Acid6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
LEU A 160
LEU A 156
MET A  98
LEU A 130
ARG A 111
1.47A18.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F0Z_A_ZMRA381_1
(SIALIDASE 2)		Zanamivir6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
ARG A  97
GLU A  63
TYR A 171
TYR A  59
TYR A 159
1.61A22.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_E_TRPE81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		L-Tryptophan6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 6
SER B  33
GLY A 120
THR A  94
ILE B   1
1.40A20.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_B_RTLB501_0
(RETINOL DEHYDRATASE)		Vitamin A6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		5 / 12
LEU C  10
LEU C   8
HIS B  31
TYR A 123
ILE A 124
1.51A1.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP3_B_RBTB1129_1
(B-CELL LYMPHOMA 6
PROTEIN)		Rifabutin6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 7
ARG A 169
LEU A 168
GLY A   1
SER A   2
1.32A18.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YN6_A_SAMA401_0
(NSP16 PROTEIN)		S-Adenosylmethionine6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
GLY A 237
GLY A 207
LEU A  32
ASP B  53
ASP A 238
1.72A20.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		Sorafenib6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		5 / 12
GLU C   2
LEU A 160
TRP A 133
LEU A 168
GLY A 100
1.67A2.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CE2_B_SVRB202_1
()		Suramin6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 8
LEU A 272
LEU A 270
LEU A 206
GLY A 207
1.10A15.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z3O_F_MFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT
B,PARE30-PARC55
FUSED TOPO IV FROM
S. PNEUMONIAE
E-SITE DNA)		Moxifloxacin6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 5
ARG A  82
GLY A  91
GLU A  89
SER B  33
1.34A16.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_A_MIYA2001_1
(TETX2 PROTEIN)		Minocycline6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 11
GLN A  72
ARG A  14
MET A  12
PRO A  43
PHE A  36
1.45A21.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYF_B_TA1B502_1
(TUBULIN BETA CHAIN)		Paclitaxel6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
ASP B  53
ASP A 238
ALA A  49
PRO A  47
ARG A  35
1.60A12.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMA_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		Aminocaproic Acid6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 8
TYR A 123
TYR A  84
TYR A 118
HIS A  93
1.08A24.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GFZ_A_CFFA940_1
(GLYCOGEN
PHOSPHORYLASE)		Caffeine6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 6
ASN B  24
PHE B  22
HIS B  13
ALA A 236
GLY A 237
1.77A7.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA271_0
(PROTEIN SSM1)		Acetic acid6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 5
GLY A  18
GLU A  19
GLY A  16
PRO A  20
1.68A20.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UPR_C_1KXC277_2
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN
PEP-V)		Abacavir6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		3 / 3
ILE A  66
LEU C   5
VAL A 152
0.87A3.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E3I_B_HISB502_0
(HISTIDINE--TRNA
LIGASE)		L-Histidine6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		5 / 11
GLU A 163
GLU A  63
TYR A  99
TYR A   7
ALA C   4
1.52A21.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_A_TKTA508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		Tropisetron6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 8
ASP B  53
ILE A  23
ARG A  35
TYR A   7
1.54A14.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ID5_A_T27A601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		Rilpivirine6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
PRO A 235
VAL B  82
VAL B   9
TYR B  66
PRO B   5
1.48A19.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIA_B_CL9B401_2
(DEOXYCYTIDINE KINASE)		Cladribine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 4
ARG A 131
ASP A 129
LEU A 160
ARG A 151
1.46A20.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4N_A_TPVA300_1
(PROTEASE)		Tipranavir6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
LEU A 270
ALA A 205
ILE A 213
GLY A 207
LEU A 266
1.23A13.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9W_A_PAUA6002_0
(PANTOTHENATE KINASE)		Pantothenic acid6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		4 / 8
THR C   3
TYR A  99
GLY C   1
ILE A  66
1.37A4.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ0_X_DXCX75_0
(CYTOCHROME C7)		Deoxycholic Acid6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 7
ILE A  23
PHE B  62
LYS A 121
GLY A 120
1.75A12.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA503_0
(CHORISMATE SYNTHASE)		Acetic acid6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 5
GLN A  72
THR A  71
ARG A  75
ARG A  79
1.52A21.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_C_SAMC405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		S-Adenosylmethionine6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 7
LYS B  58
SER B  55
PHE A   8
ASP A  30
1.69A12.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0U_A_ADNA501_1
(AURORA KINASE A)		Adenosine6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		4 / 6
VAL A 152
ALA A 150
THR A  73
LEU C   9
1.33A22.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		Azithromycin6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 6
PRO A 185
HIS A 188
ALA A 246
TYR B  10
1.35A20.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_A_D16A402_1
(THYMIDYLATE SYNTHASE)		Raltitrexed6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 7
TYR A 171
ILE A  52
LEU A 179
GLY A 175
1.23A21.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_G_CPFG1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		Ciprofloxacin6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		3 / 3
ARG A  14
GLY A  16
SER A  88
1.06A18.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9Y_A_1N1A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		Dasatinib6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
ILE A 213
ALA A 205
THR A 187
GLY A 265
LEU A 266
1.32A21.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		S-Adenosylmethionine6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 8
PRO B  32
ALA A  11
SER B  33
ASP B  34
1.51A15.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQY_A_PARA1201_1
(AAC(6')-IB)		Paromomycin6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		5 / 12
TYR A  27
GLU C   2
SER A  67
ASP B  53
ASP A  37
1.69A21.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QC6_B_KANB201_1
(BIFUNCTIONAL AAC/APH)		Kanamycin6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
TYR A 209
HIS A   3
ASP A  30
HIS A 263
GLU A 264
1.58A18.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_2
(VITAMIN D RECEPTOR)		Calcitriol6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		5 / 7
LEU C   9
LEU C   7
ILE A  66
ARG A  62
TYR A  74
1.48A4.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		Kanamycin6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		4 / 8
ASP A  37
ASP A  39
GLU C   2
ASP B  53
1.39A23.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		Ribociclib6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
ALA A  49
VAL A  28
PHE A  33
ASP A 177
LEU A 179
1.24A21.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_A_SAMA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		S-Adenosylmethionine6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
VAL B  37
ILE A  23
ILE B  35
SER B  52
HIS B  51
1.39A15.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7L_A_SHHA709_1
(LEUKOTRIENE A-4
HYDROLASE)		Vorinostat6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		5 / 12
ALA A 117
TYR A  74
GLU C   2
TRP B  60
PHE B  56
1.62A18.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_A_AICA375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		Ampicillin6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 11
GLY A 112
LEU A 126
ASN A 127
LEU A 156
LEU A 160
1.44A20.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XO7_B_ASDB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		4-Androstenedione6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 7
TYR A   7
VAL A  34
TRP A 167
LEU A 168
1.46A20.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZ4_A_BEZA784_0
(MALT REGULATORY
PROTEIN)		Benzoic Acid6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 6
HIS A  93
LEU A  95
LEU A  78
PRO A  20
1.65A19.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		Levofloxacin6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 5
SER B  33
ARG A  82
GLY A  91
GLU A  89
1.58A9.55
17.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC502_0
(ADENOSYLHOMOCYSTEINA
SE)		Adenosine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
LEU A  78
GLN A  96
THR A  94
ASN A  70
HIS A   9
1.73A18.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZUC_A_T98A201_1
(PROGESTERONE
RECEPTOR)		Tanaproget6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 10
ASN A  70
LEU A 126
TYR A   7
THR A  24
PHE A  22
1.76A21.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F9G_A_ASCA950_0
(HYALURONATE LYASE)		Vitamin C6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 7
ARG A  62
TYR A  74
ARG A  97
ASN A 114
1.69A16.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		Pentostatin6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 4
HIS A   9
LEU A 160
LEU A 126
LEU A 147
1.77A21.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_A_EV1A1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		Papaverine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
LEU A 179
VAL A  28
ILE A  52
TYR A  59
GLU A  53
1.51A21.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KI3_A_PE2A1_1
(THYMIDINE KINASE)		Penciclovir6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
GLU A 163
ILE A  66
TYR A  99
ARG A  62
GLU A  63
1.73A24.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G89_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		S-Adenosylmethionine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
GLY A 207
ALA A 205
THR A 187
ARG A 181
ALA A 182
1.55A23.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAX_D_CSCD1383_1
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		Cephalosporin C6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
LEU A  95
THR A  94
TYR B  63
HIS A   9
PHE A  22
1.73A20.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_D_HISD450_0
(HISTIDYL-TRNA
SYNTHETASE)		L-Histidine6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		5 / 12
GLU A 163
LEU A 156
TYR A  99
GLY C   1
ALA C   4
1.56A22.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVT_A_FLPA125_1
(TRANSTHYRETIN)		Flurbiprofen6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		5 / 8
LEU C   5
ALA C   6
LEU C   8
LEU A  78
SER A  77
1.54A6.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_A_29SA601_1
(ESTROGEN RECEPTOR)		Bazedoxifene6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
THR A 240
ALA A 236
ASP A 238
HIS A 263
PRO B  14
1.64A20.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G6R_A_SAMA406_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		S-Adenosylmethionine6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 7
LYS B  58
SER B  55
PHE A   8
ASP A  30
1.74A12.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU8_A_ACTA304_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		Acetic acid6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		3 / 3
ARG A  97
HIS A   9
TYR A  99
1.56A21.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_A_BCZA468_1
(NEURAMINIDASE)		Peramivir6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		3 / 3
ASP A  37
ARG A  35
ARG A  14
1.37A21.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_B_PXLB400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		Pyridoxal6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
LEU A  95
HIS A  93
GLN A  87
TYR A 123
TYR A  85
1.55A22.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BRF_A_SORA1_0
(LIN-12 AND GLP-1
PHENOTYPE PROTEIN 1,
ISOFORM A)		Sorbitol6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		3 / 3
GLY A 100
ASP A 102
SER A   4
1.49A19.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B7E_A_ZMRA1001_1
(NEURAMINIDASE)		Zanamivir6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		5 / 12
ARG A  97
ARG A  62
GLU C   2
GLU A 163
TYR A  99
1.74A21.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_1
(SAM DEPENDENT
METHYLTRANSFERASE)		S-Adenosylmethionine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		3 / 3
ASP A 223
ASP A 227
ASP A 220
1.16A24.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OGY_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		Levomefolic acid6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		5 / 12
GLU A  63
PHE A  33
ASN A  70
LEU C   8
ILE A  66
1.49A21.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_B_ACTB704_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)		Acetic acid6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		3 / 3
ARG A   6
GLY A 112
ASP A 102
0.98A17.65
22.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_B_DESB128_1
(TRANSTHYRETIN)		Diethylstilbestrol6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		5 / 11
LYS A 146
LEU C   9
LEU A  81
LEU A  95
THR A  73
1.44A19.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_A_XRAA233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		Prazosin6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		5 / 9
TRP A  60
GLY C   1
MET A   5
TYR A   7
VAL A  28
1.61A21.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_1
(ESTROGEN RECEPTOR)		Estradiol6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
THR A 187
LEU A 206
ALA A 205
GLY A 265
LEU A 266
1.15A20.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA2_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		Indomethacin6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 6
ILE A  23
ILE A  52
LEU B  54
PHE B  56
1.43A21.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_2
(PROTEASE)		Saquinavir6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		3 / 3
ARG A  48
LEU A  32
THR A  24
1.29A14.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3A_B_ADNB500_1
(SUGAR KINASE PROTEIN)		Adenosine6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		5 / 12
ASN A 114
GLY A 100
THR C   3
LEU A 156
GLY A  26
1.38A22.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_B_ECNB403_1
(FLAVOHEMOGLOBIN)		Econazole6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 11
GLN A 115
ALA A 125
LEU A 126
LEU A 160
TYR A 159
1.44A22.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_C_REAC602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		Tretinoin6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 10
ILE A 124
LEU A 147
ASN A 127
LEU A 126
LEU A 156
1.56A19.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_B_SAMB801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		S-Adenosylmethionine6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		5 / 12
GLY A  26
LEU A  32
ASP A  29
GLU C   2
TYR A 171
1.60A17.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G5J_A_0WMA1103_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		Afatinib6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 5
ASN A 114
ARG A   6
MET A  98
HIS A   9
1.67A22.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_F_GFNF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		Gatifloxacin6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 7
SER B  33
ARG A  82
GLY A  91
GLU A  89
1.17A9.55
17.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOW_A_CFXA204_1
(UNCHARACTERIZED
PROTEIN)		Cefoxitin6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
TYR A 159
GLY A 100
ASN A 114
MET A  98
ARG A  62
1.76A21.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K5Q_B_PACB559_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)		Phenylacetic acid6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 7
SER A 143
ALA A 139
TYR A  85
SER A  77
1.50A22.34
20.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKK_B_SUZB201_1
(TRANSTHYRETIN)		Sulindac6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		4 / 7
LEU A 147
LEU C  10
SER A  77
THR A  73
1.29A19.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXA_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		Adenosine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 5
GLU A 232
THR A 228
HIS A 260
LEU A 215
1.75A20.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK7_B_IMNB201_1
(TRANSTHYRETIN)		Indomethacin6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		4 / 8
LEU A 147
LEU C  10
SER A  77
THR A  73
1.24A19.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_C_1N1C501_1
(PROTEIN-TYROSINE
KINASE 6)		Dasatinib6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		6 / 12
ALA A 205
LEU A 270
THR A 187
GLY A 265
GLU A 264
LEU A 266
1.54A23.96
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_B_DVAB6_0
(GRAMICIDIN A)		L-Valine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 4
VAL A 248
TRP A 217
ALA A 245
VAL A 247
1.76A4.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGJ_A_1PQA304_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		Primaquine6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		4 / 8
PHE B  56
ILE A  23
GLY A  26
GLU C   2
1.18A17.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		Haloperidol6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		6 / 12
ALA A 158
PHE A  33
VAL A  28
VAL A  34
LEU C   5
ALA C   4
1.61A24.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA7_A_P2ZA301_1
(MAJOR PRION PROTEIN)		Promazine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 8
LEU A  95
TYR A 123
TYR A 116
ILE A 124
VAL A 152
1.69A17.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT6_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		Vitamin A6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		5 / 11
LEU C   5
LEU A 147
ALA A 136
VAL A 152
LEU A 126
1.60A6.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK6_B_LURB201_1
(TRANSTHYRETIN)		Lumiracoxib6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 8
LEU A 160
GLU A 163
ALA A 158
LEU A 130
1.28A19.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UTU_F_ADNF503_2
(ADENOSYLHOMOCYSTEINA
SE)		Adenosine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 4
GLU A 232
THR A 233
GLU A 212
HIS A   3
1.19A19.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_A_SAMA301_1
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		S-Adenosylmethionine6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		3 / 3
SER A  92
ASP B  34
ASP A 119
1.46A22.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		Mannitol6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 8
GLN A  96
PHE A   8
ASN A 114
TRP B  60
1.53A20.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AF0_A_PAUA314_0
(PANTOTHENATE KINASE)		Pantothenic acid6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 8
VAL A 103
LEU A 130
GLY A 112
TYR A 159
1.29A22.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PUO_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		Nevirapine6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		4 / 8
LEU A  81
TYR A  74
LEU C  10
TYR A  84
1.16A19.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E00_A_9CRA7223_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		Alitretinoin6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
ALA A 140
ALA A 139
GLN A 141
ALA A 135
ILE B   1
1.16A20.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_B_CVIB301_0
(PUTATIVE REGULATORY
PROTEIN)		Gentian Violet6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		5 / 12
LEU C  10
THR A  94
TYR A 116
ALA C   6
LEU A  78
1.21A9.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD2_1
(CYTOCHROME P450 2D6)		Thioridazine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 9
PHE A 208
LEU A 215
THR A 216
VAL A 261
ILE A 213
1.53A21.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MCN_P_DHIP1_0
(IMMUNOGLOBULIN
LAMBDA DIMER MCG
(LIGHT CHAIN)
PEPTIDE
N-ACETYL-D-HIS-L-PRO
-NH2)		L-Histidine6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		3 / 3
PHE A 241
TYR B  63
PRO A 235
1.35A24.49
1.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SKX_A_RFPA1_2
(ORPHAN NUCLEAR
RECEPTOR PXR)		Rifampicin6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 5
LYS A 121
PHE A  22
MET A  12
LEU B  64
1.73A23.03
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_B_TRPB403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		L-Tryptophan6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 7
ARG A 234
TRP B  95
PRO B  14
PRO B  72
1.66A21.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TYR_A_9CRA131_1
(TRANSTHYRETIN)		Alitretinoin6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		4 / 6
LEU A 147
LEU C  10
SER A  77
THR A  73
1.28A19.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_A_HSMA145_1
(D7R4 PROTEIN)		Histamine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 7
ARG A  62
TYR A   7
TYR A  99
GLU A 163
1.53A21.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEN_A_5OGA804_1
(HDAC6 PROTEIN)		Belinostat6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
PRO A  43
SER A  67
PHE A  36
PHE A  22
ASP A  39
1.78A20.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NCS_A_ACTA303_0
(N-ACETYLNEURAMINIC
ACID (SIALIC ACID)
SYNTHETASE)		Acetic acid6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		3 / 3
ILE A 213
THR A 214
PRO A 185
0.76A21.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JD6_A_TOYA501_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		Tobramycin6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 9
ASP B  53
ILE A  23
SER A  67
TYR A  59
GLU A  46
1.64A10.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_B_ADNB401_1
(PUTATIVE ADENOSINE
KINASE)		Adenosine6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		6 / 12
ASN A 114
LEU C   5
GLY A 100
THR C   3
LEU A 156
GLY A  26
1.56A21.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2002_1
(SERUM ALBUMIN)		Diflunisal6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 10
ALA A 246
ALA A 245
ALA A 205
LEU A 201
VAL A 189
1.48A19.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_B_ADNB602_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		Adenosine6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		4 / 5
THR A  73
THR A  69
THR C   3
HIS A   9
1.53A22.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		S-Adenosylmethionine6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		5 / 12
ILE A  52
VAL A  34
MET A   5
LEU C   5
TYR A  59
1.35A22.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HTQ_A_ZMRA472_1
(NEURAMINIDASE)		Zanamivir6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		5 / 12
GLU A  55
ALA C   4
GLU A 163
TYR A   7
TYR A 171
1.56A21.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_A_SAMA302_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		S-Adenosylmethionine6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		3 / 3
THR A  64
ASP B  53
SER B  55
0.75A22.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_C_SAMC301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		S-Adenosylmethionine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
GLY A 112
LEU A 156
LEU A 160
TRP A 133
TYR A 116
1.31A22.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9X_A_DB8A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		Bosutinib6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
ILE A 213
ALA A 205
THR A 187
GLY A 265
LEU A 266
1.38A21.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A60_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		Alitretinoin6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
ALA A 140
ALA A 139
GLN A 141
ALA A 135
ILE B   1
1.11A20.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_C_ADNC438_2
(ADENOSYLHOMOCYSTEINA
SE)		Adenosine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 5
GLN A 224
THR A 225
THR A 214
HIS A 260
1.68A21.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		Citalopram6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		6 / 12
TYR A   7
ILE A  52
GLY C   1
GLY A  26
LEU A  32
GLY A  56
1.77A18.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		S-Adenosylmethionine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		3 / 3
GLU A 264
HIS A 263
ASP A  30
1.56A23.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		Cobimetinib6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		4 / 4
ASN A  70
SER A 143
LEU C  10
THR A  69
1.33A20.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		S-Adenosylmethionine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 7
GLY A 107
GLY A 104
SER A   2
ASP A 106
1.20A20.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		Mannitol6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 8
GLN A  96
PHE A   8
ASN A 114
TRP B  60
1.55A20.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G24_A_ACAA1004_1
(PENTATRICOPEPTIDE
REPEAT-CONTAINING
PROTEIN AT2G32230,
MITOCHONDRIAL)		Aminocaproic Acid6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 6
ALA A 153
LEU A 156
ASP A 129
GLU A 128
1.05A18.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		Memantine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 7
GLU A  55
GLU A  63
TYR A   7
TYR A 171
1.28A21.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRG_A_ADNA300_1
(ALPHA-MOMORCHARIN)		Adenosine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 9
TYR A 159
GLY A 100
TYR A   7
GLU A  63
ARG A  62
1.54A23.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		Cholic Acid6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		3 / 3
ARG A  21
PHE A   8
LEU B  54
1.45A18.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_B_715B801_2
(DIPEPTIDYL PEPTIDASE
IV)		Sitagliptin6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		3 / 3
PHE A  22
TYR A  99
TYR A   7
1.39A17.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_C_SAMC302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		S-Adenosylmethionine6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
HIS B  31
LEU A  81
ILE A 124
SER A 143
LEU A  95
1.27A14.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOY_A_CSCA214_1
(UNCHARACTERIZED
PROTEIN)		Cephalosporin C6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 11
TYR A 159
GLY A 100
ASN A 114
MET A  98
ARG A  62
1.79A21.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FAL_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		Tretinoin6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 10
ALA A 140
ALA A 139
GLN A 141
ALA A 135
ILE B   1
1.17A20.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GTR_A_ESTA601_2
(ESTROGEN RECEPTOR)		Estradiol6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 5
LEU A 272
LEU A 215
LEU A 266
HIS A 260
1.62A20.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_A_RTLA401_0
(RETINOL DEHYDRATASE)		Vitamin A6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		5 / 12
TYR A  84
LEU C  10
HIS B  31
LEU A  78
TYR A  74
1.66A19.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_1
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		S-Adenosylmethionine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		3 / 3
ARG A 111
ASN A 127
ASP A 122
1.57A22.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_F_MZMF302_1
(ALPHA-CARBONIC
ANHYDRASE)		Methazolamide6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 10
HIS A 192
VAL A 189
LEU A 201
THR A 200
ALA A 246
1.79A19.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X61_A_SAMA701_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		S-Adenosylmethionine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
GLY A 112
ASN A 127
ARG A  97
GLU A 161
LEU A 160
1.60A17.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZI9_A_CL9A401_1
(DEOXYCYTIDINE KINASE)		Cladribine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
ILE A  66
GLU A 163
MET A   5
TYR A   7
ARG A  62
1.79A20.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_A_DVAA6_0
(GRAMICIDIN D)		L-Valine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		3 / 3
ALA A 149
VAL A 152
TRP A 133
1.80A4.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_1
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		Suvorexant6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
VAL A 152
TRP A 133
ILE A  66
ASN A  70
TYR A 159
1.57A16.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_A_ACTA603_0
(CHOLINE OXIDASE)		Acetic acid6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		3 / 3
ARG A  82
HIS A  93
SER A  88
1.43A19.28
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_B_SAMB601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		S-Adenosylmethionine6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 5
ASN B  17
PRO B  72
GLY B  18
ASP A 238
1.47A13.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_B_CHDB1130_0
(FATTY ACID-BINDING
PROTEIN)		Cholic Acid6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		5 / 12
TYR A  85
LEU A  81
LEU A  78
LEU C  10
HIS B  31
1.44A18.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CFS_A_TOYA203_1
(AAD(2''),GENTAMICIN
2''-NUCLEOTIDYLTRANS
FERASE,GENTAMICIN
RESISTANCE PROTEIN)		Tobramycin6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 8
ASP A  39
ASP A  37
GLU A  46
ASP B  53
1.66A19.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		Phenol6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 5
PHE A  33
PRO A  47
VAL A  34
ALA A  49
1.54A15.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUV_A_VK3A4558_1
(PROTEIN YGIN)		Menadione6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 7
HIS B  51
LEU B  64
MET A  12
ILE A  23
1.25A20.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WEA_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		Phenol6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 5
LEU A 168
LYS A   1
LEU A 172
GLU A 180
1.48A15.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		Ciprofloxacin6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 6
SER B  33
ARG A  82
GLY A  91
GLU A  89
1.15A9.55
17.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DK1_B_GM4B301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		Pentazocine6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 11
ALA A 125
TYR A  74
LEU A  95
TRP B  60
LEU A 147
1.68A24.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OCT_A_1N1A663_1
(TYROSINE-PROTEIN
KINASE BTK)		Dasatinib6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
LEU A  81
ALA A 139
THR A 138
TYR A  84
GLY A  83
1.51A20.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8I_C_FK5C201_1
(SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		Tacrolimus6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 6
LEU A 206
SER B  11
PHE B  22
GLU B  69
1.45A23.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3M_A_DLUA398_1
(PFV INTEGRASE)		Dolutegravir6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 8
GLY A  26
PRO A  47
GLU A  46
ARG A 239
1.35A19.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_B_NDRB1000_0
(PROGESTERONE
RECEPTOR)		Norethisterone6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		5 / 12
LEU C   8
ASN A  70
GLN A  72
LEU C  10
TYR A 116
1.80A5.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YIA_B_IMNB401_2
(THYROXINE-BINDING
GLOBULIN)		Indomethacin6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		3 / 3
LEU A  78
ARG A  79
ARG A  82
1.18A9.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_A_377A401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		Memantine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 5
GLU A  55
GLU A  63
TYR A   7
TYR A 171
1.34A21.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_C_CCSC47_0
(GLUTATHIONE
S-TRANSFERASE)		Carbocisteine6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		4 / 6
LEU A 160
GLY A 162
LYS C   1
TYR A 159
1.11A21.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF8_B_LBHB2004_1
(HDAC6 PROTEIN)		Panobinostat6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
PRO A  43
SER A  67
PHE A  36
PHE A  22
ASP A  39
1.70A20.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		Lenvatinib6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		3 / 3
TYR A 116
LEU A 126
ASP A 129
1.47A21.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XV7_A_EMHA705_2
(SERINE-ARGININE (SR)
PROTEIN KINASE 1)		Alectinib6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 4
VAL A 165
LEU A 168
LEU A 172
ASP A  29
1.26A22.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4G_B_RIOB501_0
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		Ribostamycin6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 9
ASP B  53
GLY A  26
SER A  67
THR A  71
ASP A  37
1.63A16.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_D_THAD4_1
(LIVER
CARBOXYLESTERASE I)		Tacrine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
GLY A 175
VAL A  28
LEU A 179
LEU A 172
ILE A  52
1.35A17.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_B_LNLB701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		Alpha-Linolenic Acid6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
ARG A 239
TYR A  27
TYR B  10
GLY A 237
GLY A 207
1.13A17.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		Lapatinib6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		6 / 12
ALA A  11
LEU B  54
THR A  10
LEU A  95
ASP B  34
PHE B  30
1.76A23.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BM5_A_SAMA1301_0
(METHIONINE SYNTHASE)		S-Adenosylmethionine6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		5 / 11
ARG A  62
GLU C   2
ARG A  97
ALA A  11
TYR A  74
1.77A24.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		Sorafenib6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		5 / 12
GLU C   2
LEU A 160
TRP A 133
LEU A 168
GLY A 100
1.57A3.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1010_1
(SERUM ALBUMIN)		Zidovudine6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 8
LEU A 206
HIS B  13
PHE B  22
TYR B  10
GLY A 237
1.66A19.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_A_BEZA1001_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		Benzoic Acid6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		5 / 9
LEU C   8
LEU C   9
LEU A  95
ARG A  97
TYR A 116
1.44A4.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_A_ACHA546_0
(ACETYLCHOLINESTERASE)		Acetylcholine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 8
TYR A  59
GLU A 166
TYR A 159
GLY A 162
1.41A19.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG4_A_SAMA500_0
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		S-Adenosylmethionine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
THR A 200
VAL A 248
THR A 228
ALA A 245
LEU A 215
1.44A21.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		Adenosine6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		3 / 3
LEU C   8
ASN A 127
LEU A 160
0.81A4.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVT_A_PRLA311_0
(TRANSCRIPTIONAL
REGULATOR QACR)		Proflavine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 8
LEU A 147
GLU A 148
ILE A 124
TYR A 116
1.38A17.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_A_ADNA401_1
(PUTATIVE ADENOSINE
KINASE)		Adenosine6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		6 / 12
ASN A 114
LEU C   5
GLY A 100
THR C   3
LEU A 156
GLY A  26
1.53A21.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3Q_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		Nevirapine6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		4 / 7
LEU A  81
TYR A  74
LEU C  10
TYR A  84
1.38A19.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1435_1
(CHITINASE)		Theophylline6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		3 / 3
TRP A 167
GLU A  63
TYR A  59
0.89A20.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4N_A_ACTA202_0
(NITROGEN REGULATORY
PROTEIN P-II)		Acetic acid6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 4
VAL A 103
GLY A 107
ARG A 169
VAL A 165
1.63A17.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_B_ACHB603_0
(ACETYLCHOLINESTERASE)		Acetylcholine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 7
TYR A  59
GLU A 166
TYR A 159
GLY A 162
1.40A19.85
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		Fluconazole6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 10
ALA A  49
THR A  31
LEU A 179
MET A   5
VAL A  28
1.35A18.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RBP_A_RTLA183_0
(PLASMA
RETINOL-BINDING
PROTEIN PRECURSOR)		Vitamin A6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		6 / 12
LEU C   5
LEU A 147
ALA A 140
ALA A 136
VAL A 152
LEU A 126
1.49A5.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		Sorafenib6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		5 / 12
GLU C   2
LEU A 160
TRP A 133
LEU A 168
GLY A 100
1.62A3.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKL_A_SUZA201_1
(TRANSTHYRETIN)		Sulindac6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		4 / 7
LEU A 147
LEU C  10
SER A  77
THR A  73
1.26A19.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BUE_A_RIOA1201_0
(AAC(6')-IB)		Ribostamycin6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		5 / 11
TYR A  27
GLU C   2
SER A  67
ASP B  53
ASP A  37
1.69A21.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z3J_A_NCAA302_0
(ABRIN A-CHAIN)		Nicotinamide6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 6
TYR A 171
TYR A  59
ILE A  52
GLU A  55
1.61A21.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WU8_C_ADNC502_1
(HYPOTHETICAL PROTEIN
PH0463)		Adenosine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 7
TYR A   7
ARG A  97
HIS A   9
VAL A  25
1.78A20.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_A_D16A402_1
(THYMIDYLATE SYNTHASE)		Raltitrexed6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 7
TYR A 171
ILE A  52
LEU A 179
GLY A 175
1.27A21.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X1A_A_SAMA4264_0
(CRTF-RELATED PROTEIN)		S-Adenosylmethionine6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		5 / 12
ALA C   4
GLY C   1
ILE A  66
LEU A 168
ASP A  29
1.37A2.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		Acetic acid6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		3 / 3
ARG A  62
GLU C   2
THR C   3
1.29A22.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_2_T442129_1
(TRANSTHYRETIN)		Levothyroxine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 6
LEU A 160
GLU A 163
ALA A 158
LEU A 130
1.10A19.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0A_A_GLYA73_0
(NONSTRUCTURAL
PROTEIN 1)		Glycine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 5
ALA A 139
GLN A 141
ILE A 142
ARG A 145
1.15A14.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NO9_D_95ZD302_1
(25 KDA PROTEIN
ELICITOR)		Glucosamine6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 7
GLY A 120
HIS B  31
HIS A  93
ASP A 119
1.67A20.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_B_ACTB1294_0
(GLYCINE
N-METHYLTRANSFERASE)		Acetic acid6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 7
ASN A  70
TYR A  99
TYR A 116
TYR A  74
1.54A22.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		Phenol6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 5
PHE A  33
PRO A  47
VAL A  34
ALA A  49
1.54A15.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_B_AZZB1211_1
(DEOXYNUCLEOSIDE
KINASE)		Zidovudine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
GLU A 154
LEU A 126
VAL A 152
ARG A 151
ALA A 150
1.67A21.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_D_C2FD1200_0
(GLYCINE
N-METHYLTRANSFERASE)		Levomefolic acid6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
LEU A  95
SER A  38
LEU A  78
THR A  73
THR A  71
1.43A23.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOS_A_4KOA201_1
(UNCHARACTERIZED
PROTEIN)		Cefmetazole6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
TYR A 159
GLY A 100
ASN A 114
MET A  98
ARG A  62
1.78A21.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA603_1
(CHITINASE)		Glucosamine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 8
GLY A 237
TYR A 209
ASP A 183
ARG A 181
1.58A18.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_C_29SC601_1
(ESTROGEN RECEPTOR)		Bazedoxifene6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
THR A 187
LEU A 206
ALA A 205
GLY A 265
LEU A 266
1.09A20.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_A_CRNA401_1
(CREATININE
AMIDOHYDROLASE)		Creatine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 8
HIS A   3
ASP A  29
TYR A 171
TRP A  51
1.58A23.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MRA_B_DM2B204_1
(SORCIN)		Epirubicin6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 6
TYR A 209
THR A  31
ARG A 239
ASP A 238
1.62A18.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XYZ_A_ACTA103_0
(POLYUBIQUITIN-C)		Acetic acid6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 4
LEU A 266
ILE A 213
HIS A 263
VAL A 261
1.40A14.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_C_PARC500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		Paromomycin6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 10
SER B  55
THR A  24
TYR A  74
GLU A  63
GLY A  26
1.69A11.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		Fluconazole6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		4 / 7
TYR A 159
ALA C   4
ALA C   6
THR A  73
1.35A18.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BPY_A_ACTA408_0
(THIOREDOXIN
REDUCTASE)		Acetic acid6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		3 / 3
PRO A  15
SER A  92
SER A  13
1.52A22.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_A_ADNA401_1
(ADENOSINE KINASE,
PUTATIVE)		Adenosine6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		6 / 12
ASN A 114
LEU C   5
GLY A 100
THR C   3
LEU A 156
GLY A  26
1.54A21.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_A_ADNA401_2
(ADENOSINE KINASE)		Adenosine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 4
LEU A 266
ILE A 213
GLY A 265
PHE A 208
1.31A21.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_A_CRNA303_1
(CREATININE
AMIDOHYDROLASE)		Creatine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 8
HIS A   3
ASP A  29
TYR A 171
TRP A  51
1.57A23.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N66_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE)		Mannitol6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 8
GLN A  96
PHE A   8
ASN A 114
TRP B  60
1.50A20.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1002_1
(HEMOLYTIC LECTIN
CEL-III)		Lactulose6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		3 / 3
ASP A 102
GLU A 128
GLY A 112
1.26A19.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJG_A_ADNA1501_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		Adenosine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 7
ARG A 170
TRP A  51
GLU A  53
PRO A  47
1.67A21.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		L-Leucine6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		4 / 7
ALA C   4
THR C   3
TYR A 159
GLU A  63
1.49A
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DPZ_A_TYLA2001_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		Acetaminophen6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 6
LEU A 179
ALA A  49
ASP A 183
TYR A 209
1.59A16.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)		Ribavirin6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		3 / 3
THR A 190
HIS A 263
LEU A 215
1.11A20.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		Fludarabine6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		5 / 12
ASN A 114
GLY A 100
THR C   3
LEU A 156
GLY A  26
1.38A21.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_A_PFNA1372_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		Fenoprofen6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		5 / 11
TYR A  74
LEU C   9
LEU C   7
HIS A   9
THR C   3
1.77A21.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CI6_A_NBOA607_1
(SERUM ALBUMIN)		Nabumetone6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 7
ASN A 114
ALA A 125
GLU A 128
LEU A 156
1.38A20.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		S-Adenosylmethionine6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		5 / 12
ILE A  52
GLY A  26
VAL A  34
GLY C   1
TYR A 171
1.41A22.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNC_A_CLUA808_1
(COPPER AMINE
OXIDASE, LIVER
ISOZYME)		Clonidine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 7
TYR A  74
TYR A 116
TYR A  99
HIS A   9
1.76A16.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODQ_A_ACTA703_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		Acetic acid6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 6
ARG A 239
ALA A 236
PRO A 235
PHE A 241
1.63A16.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3REQ_A_ADNA801_1
(METHYLMALONYL-COA
MUTASE)		Adenosine6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		4 / 4
TYR A  99
TYR A 159
GLU A 163
GLY C   1
1.79A18.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)		Mifepristone6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
LEU A 130
LEU A 160
GLY A 162
VAL A 165
ARG A   6
1.29A21.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC59_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		L-Valine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		3 / 3
GLY A 107
GLY A   1
GLY A 104
0.53A12.73
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V4V_A_NCAA402_0
(NADPH DEHYDROGENASE
3)		Nicotinamide6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 8
TYR A 209
PHE A 241
PRO A 235
TYR A  27
1.53A21.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		Alitretinoin6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
ALA A 140
ALA A 139
GLN A 141
ALA A 135
ILE B   1
1.13A20.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		Itraconazole6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		3 / 3
ALA A 117
TYR A 118
PRO B  32
1.17A17.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW3_A_SAMA500_1
(HISTONE
METHYLTRANSFERASE
DOT1L)		S-Adenosylmethionine6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 4
THR A 233
GLN B   8
GLU A 229
ASP A 227
1.78A22.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FAL_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		Tretinoin6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 10
ALA A 140
ALA A 139
GLN A 141
ALA A 135
ILE B   1
1.13A20.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFT_D_QMRD301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		Varenicline6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 8
TYR A 159
VAL A 165
TYR A  99
VAL A 103
1.41A20.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XOO_A_ADNA506_1
(GLYCOSAMINOGLYCAN
XYLOSYLKINASE)		Adenosine6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		4 / 6
TYR A  85
LEU C  10
LYS A 121
LEU A  95
1.32A20.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_0
(N-METHYLTRANSFERASE)		S-Adenosylmethionine6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		5 / 12
TYR A  74
ALA C   6
LEU C   8
PHE A  36
HIS A   9
1.72A22.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0I_A_BEZA990_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		Benzoic Acid6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 8
ASP A 238
LEU A 206
HIS B  13
SER B  11
1.43A21.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIA_A_SAMA206_0
(UPF0217 PROTEIN
MJ1640)		S-Adenosylmethionine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 6
LEU A  95
MET A  12
GLY A 120
LEU A  78
SER A  13
1.69A21.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_2
(ADENOSYLHOMOCYSTEINA
SE)		Fludarabine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 5
LEU A  78
GLN A  96
THR A  94
THR A  73
1.60A21.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P62_B_GEOB302_1
(DEOXYCYTIDINE KINASE)		Gemcitabine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 11
ILE A  66
GLU A 163
MET A   5
TYR A   7
ARG A  62
1.76A20.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B201_1
(ENDO-1,4-BETA-XYLANA
SE A)		Fentanyl6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		5 / 12
LEU C   8
VAL A 152
ALA A 149
TYR A 116
ALA A 150
1.69A4.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOU_A_C04A207_1
(UNCHARACTERIZED
PROTEIN)		Cefixime6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		3 / 3
GLY A 100
GLU C   2
THR C   3
1.20A21.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LD6_B_KKKB602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		Ketoconazole6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
TYR A   7
TYR A  99
PHE A  22
THR A  69
ILE A  66
1.59A20.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_A_SAMA301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		S-Adenosylmethionine6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		3 / 3
THR A  94
SER B  33
ASP A  39
1.18A22.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H9U_A_ADNA439_1
(ADENOSYLHOMOCYSTEINA
SE)		Adenosine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 10
LEU A  78
HIS A  93
THR A  94
GLN A  96
GLY A 120
1.67A20.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3005_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		Salicylic acid6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 8
LEU A 206
GLN A 242
ALA A 236
HIS B  13
1.40A20.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1Y_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		Colchicine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		3 / 3
SER A 132
ALA A 153
VAL A 152
0.90A21.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)		Rimantadine6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		4 / 6
LEU A 147
LEU C   9
ILE A 124
ARG A  97
1.54A9.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WQV_A_GCSA501_1
(CHITINASE)		Glucosamine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 11
PHE A  33
GLU A  63
TYR A 159
TYR A  99
ARG A  97
1.73A21.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_CZEA613_1
(SERUM ALBUMIN)		Cetirizine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 9
ARG A 131
ALA A 153
ASP A 129
LEU A 130
LEU A 156
1.77A20.96
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJF_B_ADNB2002_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		Adenosine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 6
ARG A 170
TRP A  51
GLU A  53
PRO A  47
1.68A21.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZQ_A_PCFA954_0
(CATECHOL
1,2-DIOXYGENASE)		Colfosceril palmitate6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 9
LEU A 109
GLU A 166
TYR A 171
LEU A 172
GLU A  55
1.51A23.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_A_017A201_2
(PROTEASE)		Darunavir6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
LEU A 201
ASP A 223
PRO A 250
VAL A 249
VAL A 247
1.25A16.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AK3_A_P2EA1201_0
(PROSTAGLANDIN E2
RECEPTOR EP3
SUBTYPE,SOLUBLE
CYTOCHROME B562)		Dinoprostone6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
THR A 187
VAL A 261
THR A 216
LEU A 230
GLN A 242
1.71A21.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		Rucaparib6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 8
GLY A 252
ALA A 199
SER A 251
GLU A 198
1.43A20.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1M_A_CAMA1422_0
(CYTOCHROME P450-CAM)		Camphor6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 7
TYR A  59
VAL A  34
GLY A  26
THR A  24
1.07A21.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HBP_A_RTLA184_0
(RETINOL BINDING
PROTEIN)		Vitamin A6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		5 / 11
LEU C   8
ALA A 136
ALA A 135
VAL A 152
LEU A 126
1.69A6.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_B_NDRB2001_0
(PROGESTERONE
RECEPTOR)		Norethisterone6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		5 / 12
LEU C   9
LEU C   7
LEU A  81
LEU A  95
TYR A 123
1.45A7.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L7I_B_SAMB501_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		S-Adenosylmethionine6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 8
PRO B  32
ALA A  11
SER B  33
ASP B  34
1.50A15.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6O_B_SAMB500_0
(HYPOTHETICAL PROTEIN)		S-Adenosylmethionine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 6
ASP A  29
VAL A  28
PRO A 210
TRP A  51
1.66A23.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1Q_A_T27A601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		Rilpivirine6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
PRO A 235
VAL B  82
VAL B   9
TYR B  66
PRO B   5
1.47A19.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M2O_B_DHIB24_0
(INSULIN B CHAIN)		L-Histidine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 6
PHE A 208
PRO A 184
LYS A 186
THR A 187
1.53A9.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		Cholic Acid6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		5 / 10
TYR A 159
ILE A  66
GLY A 100
TYR A 116
LEU C   5
1.56A20.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_D_CCSD47_0
(GLUTATHIONE
S-TRANSFERASE)		Carbocisteine6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		4 / 7
LEU A 160
GLY A 162
LYS C   1
TYR A 159
1.11A21.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		Amlodipine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 7
ILE A  52
GLU A 180
LEU A 168
VAL A  28
1.19A20.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4N_A_TPVA300_2
(PROTEASE)		Tipranavir6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 8
LEU A 270
ILE A 213
GLY A 207
LEU A 266
0.92A13.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_2
(PROGESTERONE
RECEPTOR)		Mifepristone6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		4 / 7
LEU C   8
ASN A  70
LEU A  78
TYR A  99
1.38A5.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_1
(CYTOCHROME P450 2C8)		Montelukast6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		5 / 12
SER A  77
THR A  73
THR C   3
VAL A 152
ALA A 150
1.40A19.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_B_TRPB1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		L-Tryptophan6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 8
HIS A  93
ASP A 119
ILE B   1
VAL B  85
1.08A20.96
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_A_017A201_1
(PROTEASE)		Darunavir6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
LEU A 201
ASP A 223
PRO A 250
VAL A 249
VAL A 247
1.29A16.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KOT_B_ANWB99_0
(PROTEIN S100-A13)		Amlexanox6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 8
ALA A 245
VAL A 261
THR A 216
THR A 258
1.50A16.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_D_PPFD412_1
(PHOSPHONOACETATE
HYDROLASE)		Foscarnet6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 8
PHE A  33
THR A  31
ASP A  29
HIS A   3
1.17A22.73
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		Moxifloxacin6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 7
SER B  33
ARG A  82
GLY A  91
GLU A  89
1.15A9.55
17.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJL_A_SAMA200_0
(METHIONINE REPRESSOR
PROTEIN METJ)		S-Adenosylmethionine6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		5 / 11
ALA A  11
HIS A   9
GLU A  76
ARG A  79
LEU C   9
1.50A15.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VN2_A_TLSA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		Telmisartan6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
SER A  67
ILE A  66
LEU A  32
HIS A   9
TYR A  74
1.68A22.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E0F_A_RBFA301_1
(RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA)		Riboflavin6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 11
THR A 216
GLU A 229
ALA A 246
THR A 200
VAL A 248
1.73A22.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		Dihomo-gamma-linolenic acid6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
LEU B  64
TYR B  26
PHE B  30
GLY A  26
LEU A  32
1.27A10.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IG3_A_T27A601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		Rilpivirine6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
PRO A 235
VAL B  82
VAL B   9
TYR B  66
PRO B   5
1.51A19.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EYP_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		Colchicine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		3 / 3
SER A 132
ALA A 153
VAL A 152
0.85A21.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UAC_A_ACRA501_2
(CARBOHYDRATE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT1 FAMILY
(TC 3.A.1.1.-))		Acarbose6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 7
GLU B  50
TRP A  60
ASP A  61
THR A  64
1.34A12.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGP_A_GCSA407_1
(PREDICTED
ACETYLTRANSFERASE)		Glucosamine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 8
ARG A  82
PRO A  20
GLY A  16
PRO A  15
1.51A20.59
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_E_MFXE2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		Moxifloxacin6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 5
SER B  33
ARG A  82
GLY A  91
GLU A  89
1.32A13.25
18.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		Moxifloxacin6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 6
SER B  33
ARG A  82
GLY A  91
GLU A  89
1.15A9.55
17.39
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3COT_A_STRA1501_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)		Progesterone6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 7
TYR A 159
GLU A  63
TYR A 171
TRP A  51
1.70A21.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		S-Adenosylmethionine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
HIS A   9
ARG A   6
GLY A 112
TYR A 159
TYR A   7
1.60A22.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_2
(HIV-1 PROTEASE)		Saquinavir6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 4
GLY B  29
ASP B  59
GLY A 120
THR A  10
1.11A14.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		Folic Acid6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		5 / 12
ALA C   4
GLN A  72
THR A  24
PRO A  43
TYR A  99
1.49A5.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB602_0
(ACETYLCHOLINESTERASE)		Gentian Violet6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 8
THR A 216
LEU A 215
THR A 228
VAL A 231
1.17A19.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		Sorbitol6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		4 / 5
ALA C   6
ARG A  97
ALA C   4
GLU C   2
1.68A2.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)		Deoxycholic Acid6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 9
ILE A 213
PHE A 208
VAL A 231
THR A 233
GLN A 242
1.58A18.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_D_ESTD352_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		Estradiol6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 6
SER A   2
VAL A 103
GLY A 104
GLU A 166
1.34A20.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		Ponatinib6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		6 / 12
ALA A 153
LEU C  10
LEU C   8
ILE A 124
HIS A   9
LEU C   5
1.74A20.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFQ_A_DIFA1_1
(TRANSTHYRETIN)		Diclofenac6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		4 / 6
LEU A 147
LEU C  10
SER A  77
THR A  73
1.28A19.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BC9_A_ETSA302_2
(CARBONIC ANHYDRASE 2)		Dorzolamide6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 5
GLU A 180
HIS A   3
LEU A 110
VAL A 103
1.63A21.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_H_AG2H7012_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		Agmatine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 6
ARG A   6
LEU A 110
ASP A 102
GLY A 100
1.52A17.78
16.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_B_RBFB402_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		Riboflavin6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 10
ILE A  52
GLU A  55
ASN A 174
LEU A 168
PHE A  33
1.57A21.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODJ_A_SAMA500_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		S-Adenosylmethionine6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 7
LYS B  58
SER B  55
PHE A   8
ASP A  30
1.73A12.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		S-Adenosylmethionine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
ILE A  52
GLY A  26
VAL A  34
MET A   5
TYR A  59
1.70A22.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4H_A_REAA500_1
(NUCLEAR RECEPTOR
ROR-BETA)		Tretinoin6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 11
GLN A 141
ILE A 124
ALA A 135
LEU A 156
ALA A 153
1.62A22.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_B_08JB2_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		Midazolam6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 7
PRO A 184
VAL A 261
LEU A 270
LEU A 272
1.23A16.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		S-Adenosylmethionine6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
TYR A 118
ILE B   1
ARG A  14
SER A  92
HIS A  93
1.46A21.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		Fidaxomicin6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 8
THR A  69
GLN A  65
THR A  64
SER A  38
1.42A13.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		Mannitol6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 8
GLN A  96
PHE A   8
ASN A 114
TRP B  60
1.49A20.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E6W_C_ESTC302_1
(SHORT CHAIN
3-HYDROXYACYL-COA
DEHYDROGENASE)		Estradiol6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		4 / 4
ALA A 139
GLN A  87
TYR A  85
LEU C  10
1.47A21.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_B_ADNB602_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		Adenosine6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
ASP B  34
HIS B  51
LEU B  64
LEU B  54
MET A  12
1.80A12.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)		Mifepristone6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
LEU A 130
LEU A 160
GLY A 162
VAL A 165
ARG A   6
1.28A21.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W03_B_ADNB1588_1
(ACSD)		Adenosine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 10
LEU A 215
HIS A 263
PRO A 185
LEU A 270
GLN A 262
1.51A18.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_X_CPFX1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		Ciprofloxacin6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 4
ARG A  82
GLY A  91
GLU A  89
SER B  33
1.41A18.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_B_LEIB16_0
(COIL SER L16D-PEN)		Penicillamine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 5
LEU A 172
LYS A 178
LEU A 179
GLU A 180
1.52A7.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZ8_A_GCSA208_1
(GLUCANASE/CHITOSANAS
E)		Glucosamine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 7
GLU A 163
ARG A  62
TYR A 159
GLU A  63
1.53A17.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		Mannitol6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 8
GLN A  96
PHE A   8
ASN A 114
TRP B  60
1.56A20.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FN9_A_STRA301_1
(STEROID RECEPTOR 2)		Progesterone6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		6 / 12
LEU C   5
LEU A 156
LEU A 130
ALA A 153
ALA A 125
ARG A 111
1.79A6.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_B_PXLB1005_1
(PYRIDOXINE KINASE)		Pyridoxal6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 7
SER A   2
LEU A 110
HIS A 113
ASP A  29
1.45A22.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CD2_A_FOLA307_1
(DIHYDROFOLATE
REDUCTASE)		Folic Acid6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		3 / 3
GLU A  63
ILE A  66
ARG A  97
1.01A20.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC6_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		Tretinoin6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 11
ALA A 140
ALA A 139
GLN A 141
ALA A 135
ILE B   1
1.09A20.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_A_TYLA1188_1
(BROMODOMAIN
CONTAINING 2)		Acetaminophen6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		4 / 5
LEU C   5
LEU C   8
ASN A  70
ILE A  66
1.39A9.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_1_T441128_1
(TRANSTHYRETIN)		Levothyroxine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 5
LEU A 160
GLU A 163
ALA A 158
LEU A 130
1.09A19.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_I_ACHI323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		Acetylcholine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 8
TYR A  99
ASN A 114
ILE A  66
TYR A 159
LEU A 160
1.52A22.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_B_BQ1B1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		Bedaquiline6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		5 / 8
ALA A 135
ALA A 136
ILE A 124
TYR A 123
LEU C  10
1.65A17.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		Acetic acid6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 6
PHE A  33
PRO A  47
ARG A 239
ILE A  52
1.71A21.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J96_A_TESA903_1
(3ALPHA-HYDROXYSTEROI
D DEHYDROGENASE TYPE
3)		Testosterone6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 6
TYR A 159
VAL A  34
ILE A  52
TRP A 167
1.70A20.66
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_A_AICA5001_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		Ampicillin6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 8
TYR A  59
ARG A  62
GLU A  63
TYR A 159
1.36A19.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L17_A_ZMRA512_1
(NEURAMINIDASE)		Zanamivir6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		5 / 12
ARG A  97
ARG A  62
GLU C   2
GLU A 163
TYR A  99
1.73A20.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		Mannitol6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 7
ARG A 170
ASN A 174
GLU A  53
ILE A  52
1.44A21.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UKB_A_BEZA1301_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)		Benzoic Acid6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 6
ARG A  97
LEU A 130
ALA A 153
LEU A 160
1.43A23.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GLU_B_SAMB302_0
(YCGJ)		S-Adenosylmethionine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
HIS A  93
ALA A 136
THR A 134
ALA A 125
ALA A 117
1.36A21.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFB_A_ACTA501_0
(METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER)		Acetic acid6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 7
ARG A  48
VAL A  25
ARG A  35
ILE A  23
1.21A23.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		S-Adenosylmethionine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
LEU A 172
GLY A 104
GLY A 107
VAL A 165
ASP A  29
1.62A20.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_B_LOCB503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		Colchicine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		3 / 3
SER A 132
ALA A 153
VAL A 152
0.95A21.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HVT_A_NVPA557_1
(HIV-1 REVERSE
TRANSCRIPTASE
(SUBUNIT P66))		Nevirapine6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		5 / 9
LEU A  95
TYR A 118
TYR A 123
LEU C  10
TYR A  74
1.78A19.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_B_RTLB201_0
(RETINOL-BINDING
PROTEIN 2)		Vitamin A6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
PHE A 208
THR A 187
ARG A 202
LEU A 215
LEU A 266
1.62A18.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BSZ_F_RTLF178_0
(PLASMA
RETINOL-BINDING
PROTEIN)		Vitamin A6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		5 / 11
LEU C   9
PHE A  22
ALA A  11
TYR A 116
HIS A   9
1.52A8.82
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7A_A_BEZA1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		Benzoic Acid6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		5 / 9
LEU C   8
LEU C   9
LEU A  95
ARG A  97
TYR A 116
1.40A4.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HAV_A_SRYA403_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		Streptomycin6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 8
ASP B  53
ASP A  39
ASP B  34
TYR B  66
1.31A17.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB202_1
(PROTEIN S100-A4)		Trifluoperazine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		3 / 3
GLU A 128
LEU A 130
ASP A 129
1.23A15.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M2P_B_DHIB24_0
(INSULIN B CHAIN)		L-Histidine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		3 / 3
TYR A 209
GLY A 207
PHE A 241
1.16A9.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		Salicylic acid6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 7
LEU A  81
TYR A 123
ILE A 142
GLY A  83
1.37A19.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		Efavirenz6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		5 / 10
LEU A  95
TYR A 118
TYR A 123
LEU C  10
TYR A  74
1.75A19.93
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3477_1
(NEURAMINIDASE)		Zanamivir6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		5 / 12
ARG A  97
ARG A  62
GLU C   2
GLU A 163
TYR A  99
1.70A19.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		Novobiocin6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 7
ARG A  75
LEU A  78
GLN A  87
GLN A  72
1.44A23.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_A_ADNA500_1
(ADENOSYLHOMOCYSTEINA
SE)		Adenosine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
LEU A 168
LEU A 110
LEU A 109
GLY A 112
HIS A 113
1.52A19.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_B_IBPB2002_1
(SERUM ALBUMIN)		Ibuprofen6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 10
ALA A 246
ALA A 245
ALA A 205
LEU A 201
VAL A 189
1.46A19.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_A_SAMA501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		S-Adenosylmethionine6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
GLY A  18
ASP B  34
ASP A  39
LEU B  64
LEU B  54
1.49A21.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_A_PXLA400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		Pyridoxal6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 11
LEU A  95
HIS A  93
GLN A  87
TYR A 123
TYR A  85
1.54A22.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_E_PARE500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		Paromomycin6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
SER B  52
LEU A  32
TYR A  27
ASP A  30
GLY A 237
1.60A11.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJL_D_ERYD1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		Erythromycin6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		5 / 12
SER A  67
ARG A  62
GLU A  63
GLU C   2
MET A  98
1.74A13.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_2
(HIV-1 PROTEASE)		Saquinavir6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		3 / 3
ARG A 181
VAL A  28
THR A  31
1.49A14.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		Calcidiol6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		3 / 3
THR A  94
LEU A  95
LEU C   8
0.98A12.16
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LRB_A_ACRA1003_1
(ALPHA-1,4 GLUCAN
PHOSPHORYLASE)		Acarbose6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 6
THR A  73
TYR A  74
TYR A  99
PHE B  56
1.47A14.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW7_A_VPXA2001_1
(PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME)		Vorapaxar6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		5 / 12
TYR A 123
LEU C   8
LEU A  78
LEU A  81
ALA A  11
1.44A19.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOV_A_KOVA204_1
(UNCHARACTERIZED
PROTEIN)		Cefuroxime6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
TYR A 159
GLY A 100
ASN A 114
MET A  98
ARG A  62
1.76A21.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		Digoxin6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		3 / 3
TRP A  51
VAL A 103
ARG A 108
1.13A20.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS6_A_J3ZA302_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE 14)		Estrone6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 8
HIS A 260
GLN A 218
LEU A 272
THR A 228
1.49A21.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7X_A_CFFA863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		Caffeine6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 6
ASN B  24
PHE B  22
HIS B  13
ALA A 236
GLY A 237
1.77A6.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_A_BRLA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		Rosiglitazone6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
PHE A  22
ARG A  79
SER A  77
LEU A  95
TYR A 116
1.63A21.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IK1_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		Camphor6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 5
LEU A  32
GLY A  26
ASP A  37
ILE A  23
1.50A20.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_B_RBFB201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		Riboflavin6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 7
VAL A 165
ARG A 157
GLU A 161
LEU A 126
1.79A22.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_A_SAMA900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		S-Adenosylmethionine6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
PHE B  56
TYR A  99
GLY A  26
HIS A   9
ILE A  23
1.52A10.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RYA_A_MTLA501_1
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))		Mannitol6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		3 / 3
GLU A  63
TYR A 159
GLU A 163
1.25A20.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		Dexrazoxane6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 7
THR A  73
TYR A  74
TYR A 116
LEU A  95
1.12A20.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNW_D_GCSD302_1
(25 KDA PROTEIN
ELICITOR)		Glucosamine6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 7
GLY A 120
HIS B  31
HIS A  93
ASP A 119
1.72A20.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		Mannitol6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 8
ARG A 170
ASN A 174
GLU A  53
ILE A  52
1.49A21.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDS_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		Estradiol6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
SER A   4
VAL A  28
SER B  55
PHE A   8
PHE A  33
1.69A20.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GH9_A_MIXA1003_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15)		Mitoxantrone6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 5
TYR A  85
GLY A  83
HIS A  93
ASP A 119
1.48A19.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM8_B_L8PB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		Cidofovir6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 8
TRP A 133
GLN A 144
ALA A 153
GLN A 155
1.44A19.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL6_A_NIMA614_1
(LACTOPEROXIDASE)		Nimesulide6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		4 / 7
GLN A 115
GLU C   2
ARG A   6
PHE B  56
1.65A17.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT7_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		Vitamin A6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		5 / 11
LEU C   5
LEU A 147
ALA A 136
VAL A 152
LEU A 126
1.57A6.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_A_ACTA294_0
(GLYCINE
N-METHYLTRANSFERASE)		Acetic acid6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 6
ASN A  70
TYR A  99
TYR A 116
TYR A  74
1.56A22.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIU_A_9CRA201_1
(RXR-LIKE PROTEIN)		Alitretinoin6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
ILE A 124
ALA A 140
ALA A 135
GLN A 141
ARG A 145
1.53A22.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKJ_A_SUZA201_1
(TRANSTHYRETIN)		Sulindac6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		4 / 7
LEU A 147
LEU C  10
SER A  77
THR A  73
1.28A19.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ1_K_6ELK501_0
(PROTEIN CEREBLON)		Thalidomide6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 7
HIS A 113
TRP B  60
PHE B  56
THR A 134
1.70A13.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		S-Adenosylmethionine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
ILE A  52
GLY A  26
VAL A  34
MET A   5
TYR A  59
1.70A22.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I00_A_D16A315_1
(THYMIDYLATE SYNTHASE)		Raltitrexed6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 9
PHE A  33
GLU A  55
ILE A  52
LEU A 179
GLY A 175
1.75A21.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TZC_D_EF2D505_1
(PROTEIN CEREBLON)		Thalidomide6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 8
THR A 134
HIS A 113
TRP B  60
PHE B  56
1.69A13.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6O_A_1N1A1892_1
(EPHRIN TYPE-A
RECEPTOR 4)		Dasatinib6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
ILE A 213
ALA A 205
THR A 187
GLY A 265
LEU A 266
1.38A21.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXN_A_SAMA901_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		S-Adenosylmethionine6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
LEU A 206
HIS A 188
VAL B  93
ASP B  98
ASP B  96
1.80A20.60
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4F_A_ASRA140_0
(LYSOZYME C)		Arsanilic acid6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		3 / 3
ASN A 114
ALA A 125
ASN A 127
1.34A16.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_H_377H401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		Memantine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 6
TYR A 171
GLU A  55
GLU A  63
TYR A   7
1.27A21.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_Q_TRPQ1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		L-Tryptophan6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 8
HIS A  93
ASP A 119
ILE B   1
VAL B  85
1.09A20.96
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJI_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		Phylloquinone6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 10
SER A   2
GLY A 104
ARG A 169
LEU A 168
PHE A  22
1.61A16.15
8.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_C_MTXC604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		Methotrexate6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		5 / 12
LEU A 147
LEU A 126
SER A 143
TYR A  74
THR C   3
1.66A18.92
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1479_0
(MJ0495-LIKE PROTEIN)		Deoxycholic Acid6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		4 / 5
THR C   3
ILE A  66
GLU A  63
PHE A  22
1.49A2.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_1
(METHOXY MYCOLIC ACID
SYNTHASE 4)		S-Adenosylmethionine6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		3 / 3
SER A  92
THR B  86
GLN B   2
0.96A25.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E7F_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		Levomefolic acid6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		5 / 12
GLU C   2
ASN A 114
LEU C  10
SER A  67
ASN A  70
1.51A3.72
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6P_B_TA1B502_1
(TUBULIN BETA CHAIN)		Paclitaxel6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
LEU A  95
HIS A   9
PHE B  56
THR A  94
LEU B  54
1.64A19.46
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_A_RBFA201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		Riboflavin6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
ALA A 205
GLN B   8
ILE A 213
ASN B  24
GLY A 207
1.63A18.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_C_377C401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		Memantine6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		4 / 6
TYR A   7
GLU A 163
TYR A 159
LEU C   5
1.71A21.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_A_SHHA2004_1
(HDAC6 PROTEIN)		Vorinostat6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
PRO A  43
SER A  67
PHE A  36
PHE A  22
ASP A  39
1.73A20.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_A_DM2A1106_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		Epirubicin6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 11
SER A  67
MET A   5
PHE A  33
ARG A 170
GLN A  54
1.45A13.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7R_A_NCTA440_1
(CYTOCHROME P450-CAM)		Nicotine6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 7
THR A  10
VAL A  25
ASP B  53
ILE A  23
1.10A20.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND7_B_TA1B601_2
(TUBULIN BETA-2B
CHAIN)		Paclitaxel6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		3 / 3
THR A  69
PRO A  20
ARG A  21
1.28A19.46
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA845_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		Phylloquinone6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 8
MET A   5
ARG A 239
ALA A  49
LEU A  32
1.39A15.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_A_08JA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		Midazolam6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 8
PRO A 184
VAL A 261
LEU A 270
LEU A 272
1.16A16.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		Lobeglitazone6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		3 / 3
SER A  13
HIS A  93
TYR A 118
1.32A21.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_A_LEIA16_0
(COIL SER L16D-PEN)		Penicillamine6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		4 / 6
GLN A  72
LEU C   7
GLU A  76
LEU C   9
1.58A7.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		Sorbitol6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 7
PHE A 241
ASP A  30
TYR A  27
TYR B  63
1.79A20.22
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		Spermine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 8
GLU A  53
GLU A  55
TYR A 171
ARG A 170
1.63A20.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IMA_D_ADND604_1
(PYRUVATE KINASE)		Adenosine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		3 / 3
ARG A 170
GLU A  55
ASN A 174
1.65A19.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6S_A_CXQA507_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		Benzatropine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 5
ALA A 135
TYR A 123
GLN A 141
ILE A 142
1.37A23.08
24.21
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQ8_A_TOPA2001_1
(DIHYDROFOLATE
REDUCTASE)		Trimethoprim6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 9
ALA A 139
LEU A  81
ASP A 137
ILE A 124
THR A 138
1.64A17.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		S-Adenosylmethionine6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
VAL B  37
ILE A  23
ILE B  35
SER B  52
HIS B  51
1.40A17.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4G_B_ZMRB466_1
(NEURAMINIDASE)		Zanamivir6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		5 / 12
ARG A  97
ARG A  62
GLU C   2
GLU A 163
TYR A  99
1.72A21.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6D_A_SAMA1350_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		S-Adenosylmethionine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
LEU A 172
GLY A 104
GLY A 107
VAL A 165
ASP A  29
1.56A20.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_A_SAMA401_1
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		S-Adenosylmethionine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		3 / 3
ASP A 183
ARG A 181
ASP A 238
1.63A20.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W03_A_ADNA1588_1
(ACSD)		Adenosine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 10
LEU A 215
HIS A 263
PRO A 185
LEU A 270
GLN A 262
1.52A18.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AVP_A_MV2A313_1
(PANTOTHENATE KINASE)		Dexpanthenol6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 7
ASP A 119
HIS B  31
LEU A  78
ILE A  23
1.15A22.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_1
(AMINOMETHYLTRANSFERA
SE)		Levomefolic acid6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		3 / 3
ASP A  30
GLU A 232
TYR B  10
1.51A22.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOY_A_HISA1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		L-Histidine6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 10
ILE B   1
GLY A 120
ALA A 117
TYR A 118
HIS A  93
1.51A18.83
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AW1_A_COXA264_1
(CARBONIC ANHYDRASE
II)		Valdecoxib6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
ILE A 124
HIS B  31
LEU A  81
LEU A  95
THR A  94
1.59A21.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OAP_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		Alitretinoin6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
ALA A 140
ALA A 139
GLN A 141
ALA A 135
ILE B   1
1.17A20.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_A_SAMA484_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		S-Adenosylmethionine6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 11
GLY A 237
ALA B  15
ASN B  24
LEU B  39
PHE B  70
1.62A19.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		Thiopental6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		4 / 6
LEU C  10
TYR A 118
ALA A 139
LEU A  95
1.43A17.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_A_URFA302_1
(URIDINE
PHOSPHORYLASE)		Fluorouracil6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 7
THR A 187
GLY A 207
GLN A 242
ILE A 213
1.37A18.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YIZ_G_EF2G501_1
(PROTEIN CEREBLON)		Thalidomide6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 7
HIS A 113
TRP B  60
PHE B  56
THR A 134
1.71A13.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNX_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		Paclitaxel6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
HIS A   9
PHE B  56
THR A  94
ARG A  75
ARG A  35
1.63A19.46
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		Sertraline6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		5 / 12
LEU A 160
LEU A 130
TYR A 159
ALA A 153
LEU C   8
1.51A21.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMN_A_DB8A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		Bosutinib6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
ILE A 213
ALA A 205
LYS A 186
ALA A 236
ASP A 238
1.50A19.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		Eszopiclone6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 6
GLU A  63
ILE A  66
TYR A 159
VAL A 103
1.36A21.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_D_ADND500_2
(ADENOSYLHOMOCYSTEINA
SE)		Adenosine6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 5
GLN A  96
THR A  10
HIS B  51
LEU B  64
1.68A21.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_B_BRLB2_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		Rosiglitazone6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		5 / 12
PHE A  22
SER A  77
LEU C   7
LEU A  95
TYR A 116
1.54A22.04
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E5Z_A_CCSA106_0
(PROTEIN/NUCLEIC ACID
DEGLYCASE DJ-1)		Carbocisteine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 10
GLY A 207
ALA A 205
PRO A 185
THR A 187
HIS A 188
1.65A22.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_B_SAMB301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		S-Adenosylmethionine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
GLY A 112
LEU A 156
LEU A 160
TRP A 133
TYR A 116
1.33A22.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_4
(POL POLYPROTEIN)		Indinavir6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		3 / 3
ARG A 157
VAL A 165
GLY A 104
0.90A14.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G89_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		S-Adenosylmethionine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 11
GLY A 207
ALA A 205
THR A 187
ARG A 181
ALA A 182
1.55A23.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T6Z_A_RBFA296_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		Riboflavin6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 11
VAL A 165
VAL A 103
GLU A 161
ARG A 169
GLU A 166
1.68A19.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI6_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		Methotrexate6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		5 / 12
LEU A 126
SER A 143
ILE A 124
TYR A  74
THR C   3
1.62A19.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		Phenol6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 5
PHE A  33
PRO A  47
VAL A  34
ALA A  49
1.51A15.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAH_A_LNRA600_1
(PHENYLALANINE
HYDROXYLASE)		Norepinephrine6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		4 / 6
LEU A  32
PHE A  33
HIS A   9
GLU C   2
1.69A21.86
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W6H_A_AZMA303_1
(CARBONIC ANHYDRASE 1)		Acetazolamide6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 8
HIS A 192
LEU A 201
THR A 190
HIS A 191
1.75A25.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_B_SAMB401_1
(METHYLTRANSFERASE
MPPJ)		S-Adenosylmethionine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		3 / 3
ARG A 145
ASP A 137
ASP A 122
1.77A20.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_A_REAA502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		Tretinoin6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
ALA A 140
ALA A 139
GLN A 141
ALA A 135
ILE B   1
1.12A20.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_A_ADNA401_1
(CYCLIN-DEPENDENT
KINASE 9)		Adenosine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 8
ILE A  52
GLY A  26
ALA A  49
LEU A 179
1.05A22.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEN_B_5OGB804_1
(HDAC6 PROTEIN)		Belinostat6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
PRO A  43
SER A  67
PHE A  36
PHE A  22
ASP A  39
1.74A20.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_C_HFGC1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		Halofuginone6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		5 / 12
LEU A 160
THR C   3
GLU C   2
HIS A   9
THR A  69
1.66A21.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVP_A_GBMA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		Glyburide6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		5 / 11
TYR A  74
LEU C  10
ILE A 124
HIS A   9
LEU A 156
1.43A21.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G10_A_ACTA301_0
(GLUTATHIONE
S-TRANSFERASE
HOMOLOG)		Acetic acid6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 6
ILE A  66
TYR A 159
TYR A   7
TYR A  99
1.61A23.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_A_SAMA301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		S-Adenosylmethionine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
ALA A 205
ASP A 183
PHE A 208
GLY A 265
GLU A 212
1.75A21.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2002_1
(SERUM ALBUMIN)		Diflunisal6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 11
ALA A 246
ALA A 245
ALA A 205
LEU A 201
VAL A 189
1.46A19.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2MJI_A_KTRA201_1
(FATTY ACID-BINDING
PROTEIN, INTESTINAL)		Ketorolac6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
TYR A  99
GLU A  63
TYR A 171
LEU A 168
TYR A 159
1.60A20.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QC6_A_KANA201_1
(BIFUNCTIONAL AAC/APH)		Kanamycin6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 11
TYR A 209
HIS A   3
ASP A  30
HIS A 263
GLU A 264
1.61A18.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNM_A_1N1A1001_1
(-)		Dasatinib6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
ILE A 213
ALA A 205
THR A 187
GLY A 265
LEU A 266
1.55A21.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AWU_A_4CHA502_0
(OXIDOREDUCTASE,
FMN-BINDING)		Parachlorophenol6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 7
ASN B  24
TYR B  10
LEU B  65
PHE A 241
1.42A14.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PHH_A_LDPA414_1
(LYSINE-SPECIFIC
DEMETHYLASE 4D)		Dopamine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 6
GLU A 254
ALA A 199
LEU A 201
SER A 251
1.73A23.32
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_A_MTLA805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		Mannitol6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 8
GLN A  96
PHE A   8
ASN A 114
TRP B  60
1.49A20.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J2T_C_VLBC503_1
(TUBULIN BETA-2B
CHAIN
TUBULIN ALPHA-1B
CHAIN)		Vinblastine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 9
TYR A  74
PHE A  22
THR A  10
TYR A 118
LEU A  78
1.79A18.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKL_B_SUZB201_1
(TRANSTHYRETIN)		Sulindac6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		4 / 8
LEU A 147
LEU C  10
SER A  77
THR A  73
1.28A19.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OA1_A_TRPA2002_0
(TRYPTOPHAN
HALOGENASE)		L-Tryptophan6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
PRO A  43
ILE A  66
PHE A  36
GLU A  63
GLU A  46
1.58A20.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		Abiraterone6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 11
ALA A  40
TYR A  74
ASN A  70
ASP A  37
THR A  64
1.25A21.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		Eszopiclone6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 7
GLU A  63
ILE A  66
TYR A 159
VAL A 103
1.34A21.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGC_B_TA1B601_1
(TUBULIN BETA CHAIN)		Paclitaxel6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		5 / 12
VAL A 103
ASP A 102
THR C   3
GLY A 112
LEU A 160
1.66A19.46
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		Indomethacin6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 10
GLU A  46
ARG A  35
GLY A  26
LEU A 179
ILE A  52
1.56A21.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VAO_A_ACTA601_0
(VANILLYL-ALCOHOL
OXIDASE)		Acetic acid6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 5
TYR A   7
PHE A  33
ILE A  52
TYR A  59
1.80A18.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ4_A_ACTA403_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		Acetic acid6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		3 / 3
VAL A 247
LEU A 201
VAL A 249
0.90A20.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_1
(PROTEASE)		Saquinavir6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
LEU A 201
ASP A 223
PRO A 250
VAL A 249
VAL A 247
1.26A14.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_E_REAE504_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		Tretinoin6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 11
ALA A 140
ALA A 139
GLN A 141
ALA A 135
ILE B   1
1.03A20.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_A_CVIA608_0
(ACETYLCHOLINESTERASE)		Gentian Violet6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 7
THR A 216
LEU A 215
THR A 228
VAL A 231
1.15A19.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		Mannitol6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 8
GLN A  96
PHE A   8
ASN A 114
TRP B  60
1.59A20.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_ACTA294_0
(GLYCINE
N-METHYLTRANSFERASE)		Acetic acid6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 6
ASN A  70
TYR A  99
TYR A 116
TYR A  74
1.55A22.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB512_1
(PHOSPHOLIPASE A2)		Suramin6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 5
VAL A 231
THR A 228
THR A 233
ARG A 234
1.56A16.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_1
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		S-Adenosylmethionine6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		3 / 3
ASP B  53
GLU B  50
SER A  67
1.61A15.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_4
(HIV-1 PROTEASE)		Saquinavir6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 4
GLY B  29
ASP B  59
GLY A 120
THR A  10
1.04A16.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA402_1
(HIV-1 PROTEASE)		Saquinavir6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 5
LEU A 168
PRO A 105
VAL A 103
ASP A  29
1.62A16.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCX_A_ZMRA519_0
(NEURAMINIDASE)		Zanamivir6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		5 / 12
ARG A  97
ARG A  62
GLU C   2
GLU A 163
TYR A  99
1.75A20.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PG2_A_ADNA552_1
(METHIONYL-TRNA
SYNTHETASE)		Adenosine6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		5 / 11
ALA C   4
GLU A 163
GLY C   1
ILE A  66
TYR A  59
1.66A2.01
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_E_GCSE710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		Glucosamine6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 8
ARG A  35
ASP B  53
ILE A  23
HIS B  51
1.65A22.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_C7HA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		Cyproheptadine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 5
TYR A 118
GLY A  83
TYR A 123
TYR A  84
1.33A19.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_1
(MODIFICATION
METHYLASE RSRI)		S-Adenosylmethionine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		3 / 3
ASP A 220
HIS A 260
ASP A 223
1.09A22.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WQW_A_GCSA501_1
(CHITINASE)		Glucosamine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 11
PHE A  33
GLU A  63
TYR A 159
TYR A  99
ARG A  97
1.76A21.87
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2D_F_LFXF102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		Levofloxacin6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		3 / 4
ARG A 219
GLY A 221
GLU A 222
1.46A19.09
21.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_B_0LIB1771_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		Ponatinib6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 10
LEU A  95
ILE A 124
TYR A 118
ARG A 157
LEU A 156
1.66A22.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_G_377G401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		Memantine6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		4 / 6
TYR A   7
GLU A 163
TYR A 159
LEU C   5
1.56A21.65
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		Levoleucovorin6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		3 / 3
SER A 251
GLU A 253
GLU A 254
1.78A18.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT6_A_DVAA6_0
(GRAMICIDIN C)		L-Valine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		3 / 3
ALA A 199
VAL A 247
TRP A 217
1.39A4.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		S-Adenosylmethionine6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 5
TYR B  66
SER B  28
ASP A  37
ILE A  23
1.46A17.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		Phenol6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 5
PHE A  33
PRO A  47
VAL A  34
ALA A  49
1.52A15.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3O_A_EFZA1557_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		Efavirenz6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		5 / 9
LEU A  95
TYR A 118
TYR A 123
LEU C  10
TYR A  74
1.66A19.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_A_SAMA401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		S-Adenosylmethionine6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
ALA A  49
GLY A 175
ASP B  53
ARG A  35
PRO A  47
1.68A20.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_A_AG2A506_1
(HOMOSPERMIDINE
SYNTHASE)		Agmatine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 6
ARG A   6
ASP A 102
VAL A  28
ASP A  29
1.76A21.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UIN_H_QI9H1226_0
(FAB 314.3)		Quinine6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
SER B  55
GLY A 237
ARG A 239
PHE A 241
LEU A  32
1.71A18.34
20.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K8M_A_ACRA720_1
(ALPHA-AMYLASE, SUSG)		Acarbose6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		4 / 7
GLU A 148
TRP A 133
LEU C   8
ASN A 114
1.77A16.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1479_0
(TRANSLATION
ELONGATION FACTOR
SELB)		Deoxycholic Acid6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		4 / 5
THR C   3
ILE A  66
GLU A  63
PHE A  22
1.52A2.00
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOT_B_VDNB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		Vardenafil6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
HIS B  84
MET A  12
ILE B  35
SER B  57
SER B  52
1.60A14.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGZ_A_SPRA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		Spiramycin6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 9
LEU A 179
HIS A   3
ILE A  52
GLU A  53
GLU A 173
1.42A21.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_F_CCSF47_0
(GLUTATHIONE
S-TRANSFERASE)		Carbocisteine6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		4 / 5
LEU A 160
GLY A 162
LYS C   1
TYR A 159
1.11A21.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5R_A_KANA2002_1
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		Kanamycin6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		5 / 11
VAL A  34
TYR A  59
ILE A  23
GLU C   2
ILE A  66
1.79A23.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QL8_A_BEZA143_0
(PUTATIVE REDOX
PROTEIN)		Benzoic Acid6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 7
THR A  94
ALA A  11
PRO B  32
ARG A  21
1.37A17.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7U_A_FVTA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)		Aminolevulinic acid6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 6
VAL A  28
ASN A 174
ILE A  52
GLU A  55
1.61A19.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_C_D16C509_1
(THYMIDYLATE SYNTHASE)		Raltitrexed6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 10
PHE A  33
GLU A  55
ILE A  52
ASP A 177
GLY A 175
1.72A23.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4G_B_ZMRB466_2
(NEURAMINIDASE)		Zanamivir6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		3 / 3
ASP A  39
ARG A  21
ILE A  23
1.49A21.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)		Tetracycline6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 7
THR A  94
SER A  92
PRO B  32
LEU B  64
1.34A9.87
20.47
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_A_1N1A501_1
(PROTEIN-TYROSINE
KINASE 6)		Dasatinib6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		6 / 12
ALA A 205
LEU A 270
THR A 187
GLY A 265
GLU A 264
LEU A 266
1.59A23.96
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GAH_A_ACRA497_2
(GLUCOAMYLASE-471)		Acarbose6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 6
ALA A 150
ARG A  97
LEU A 147
TRP A 133
1.62A20.25
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_C_DESC129_1
(TRANSTHYRETIN)		Diethylstilbestrol6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		4 / 6
LEU C   5
ALA C   6
LEU C   8
SER A  77
1.37A5.51
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_E_PARE500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		Paromomycin6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
LEU A  32
THR A  31
ASP A  30
ASP A  29
TYR A 171
1.69A21.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN0_A_TDZA501_1
(CYTOCHROME P450 2C8)		Troglitazone6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
THR A 258
LEU A 215
VAL A 189
VAL A 247
GLU A 229
1.13A19.54
None
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5J6H_A_NCAA402_0
(H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, Q10 ALPHA
CHAIN)		Nicotinamide6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		3 / 3
PRO A  47
ARG A  48
GLU A  53
0.36A75.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_J_AG2J7013_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		Agmatine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 7
LEU A 110
ASP A 102
GLY A 100
ARG A   6
1.52A16.23
17.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ROX_B_T44B128_1
(TRANSTHYRETIN)		Levothyroxine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 6
LEU A 160
GLU A 163
ALA A 158
LEU A 130
1.26A19.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA734_1
(ALPHA AMYLASE)		Acarbose6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 6
ASN A 174
TRP A  51
TYR A 171
TRP A  60
1.70A22.17
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		Mannitol6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 8
GLN A  96
PHE A   8
ASN A 114
TRP B  60
1.50A20.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_D_NCAD302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		Nicotinamide6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		4 / 7
LEU C  10
ALA A 139
TYR A 123
TYR A 116
1.51A3.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KI7_B_ID2B2_0
(THYMIDINE KINASE)		Idoxuridine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
GLU A 163
ILE A  66
TYR A  99
ARG A  62
GLU A  63
1.60A24.78
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_C_DXCC92_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		Deoxycholic Acid6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 4
VAL A  25
PHE B  56
PHE B  30
VAL B  27
1.78A12.73
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		Mannitol6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 8
ARG A 170
ASN A 174
GLU A  53
ILE A  52
1.45A21.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		Mercaptopurine6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		4 / 7
GLN A 155
LEU A 156
LEU C   8
LEU C   5
1.12A21.48
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE9_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		Calcitriol6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		5 / 12
LEU A 147
LEU C  10
SER A  77
VAL A 152
LEU C   5
1.59A21.84
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UR0_B_SVRB516_1
(RNA-DEPENDENT RNA
POLYMERASE)		Suramin6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 7
PRO A  15
GLY A  18
ASP B  34
ARG A  21
1.34A20.15
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VM1_A_TAZA504_1
(BETA-LACTAMASE SHV-1)		Tazobactam6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		3 / 3
ASP A 220
TYR A 257
GLU A 253
1.75A22.88
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KS8_A_B49A701_1
(SERINE/THREONINE-PRO
TEIN KINASE PAK 6)		Sunitinib6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 10
ILE A  52
ALA A  49
GLY A 175
LEU A 179
ASP A  29
1.49A24.26
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_C_ACTC2294_0
(GLYCINE
N-METHYLTRANSFERASE)		Acetic acid6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 7
ASN A  70
TYR A  99
TYR A 116
TYR A  74
1.55A22.99
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCX_A_ZMRA519_1
(NEURAMINIDASE)		Zanamivir6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		3 / 3
TRP A  60
ILE A  52
GLU C   2
1.38A20.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_A_SPMA202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		Spermine6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		4 / 8
GLU A 163
ILE A  66
GLU C   2
GLU A  63
1.10A20.58
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ0_G_EF2G501_1
(PROTEIN CEREBLON)		Thalidomide6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 7
HIS A 113
TRP B  60
PHE B  56
THR A 134
1.75A13.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UW0_A_SAMA1506_0
(WBDD)		S-Adenosylmethionine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
ALA A 245
ILE A 213
GLU A 212
LEU A 272
VAL A 261
1.47A18.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAV_A_RAVA183_1
(FERRITIN LIGHT CHAIN)		Pentobarbital6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		4 / 6
LEU C  10
TYR A 118
ALA A 139
LEU A  95
1.44A17.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERS_A_ACTA803_0
(GEPHYRIN)		Acetic acid6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		3 / 3
THR A  73
ALA C   6
ASN A  70
1.07A21.53
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA5_A_ZMRA501_1
(NEURAMINIDASE)		Zanamivir6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		5 / 12
GLU A  55
ALA C   4
GLU A 163
TYR A   7
TYR A 171
1.54A19.75
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		Fusidic Acid6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		3 / 3
VAL A 249
ALA A 199
HIS A 192
1.58A18.71
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ARM_A_OINA401_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		Hyoscyamine6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		4 / 7
GLY A  26
HIS A   9
TYR A  99
LYS C   1
1.40A16.36
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IG3_B_VIBB501_1
(THIAMIN
PYROPHOSPHOKINASE)		Thiamine6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		4 / 7
GLN A  65
LEU C   8
SER A  67
ASN A  70
1.42A21.19
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_B_TA1B502_1
(TUBULIN BETA CHAIN)		Paclitaxel6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 10
VAL B  82
HIS B  84
THR A  94
GLN A  96
LEU B  54
1.64A12.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CNJ_D_NCTD402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		Nicotine6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 8
THR A 233
TYR B  10
TRP A 204
LEU A 206
1.64A21.65
20.10
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		Nafcillin6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		3 / 3
SER A  92
GLY A  91
ARG A  17
1.48A13.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		Acetylcholine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 8
TYR A  85
TYR A 123
GLN A  96
SER A  77
1.46A20.63
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CAJ_A_EZLA265_1
(CARBONIC ANHYDRASE 2)		Ethoxzolamide6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 10
HIS A 192
VAL A 189
LEU A 201
THR A 200
TRP A 274
1.65A21.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_A_EPAA502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		Icosapent6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 10
LEU B  54
PHE B  62
ARG A  21
ALA A  11
PRO B   5
1.70A12.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		Phylloquinone6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 7
MET A   5
ARG A 239
ALA A  49
LEU A  32
1.41A15.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_1
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		S-Adenosylmethionine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		3 / 3
ASP A 183
ARG A 181
ASP A 238
1.55A21.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F6D_A_ACRA995_1
(GLUCOAMYLASE GLU1)		Acarbose6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
TYR A   7
GLY A 162
GLU A 163
ARG A  62
GLU A  63
1.67A18.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RXH_A_HSMA7_1
(CATIONIC TRYPSIN)		Histamine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 5
ASP A 102
SER A   4
VAL A  28
GLY A 100
1.75A20.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_2
(TRANSTHYRETIN)		Liothyronine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 8
LEU A 160
GLU A 163
ALA A 158
LEU A 130
1.19A19.46
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIU_B_9CRB202_1
(RXR-LIKE PROTEIN)		Alitretinoin6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
ALA A 136
ALA A 140
GLN A 141
HIS A  93
LEU A  81
1.35A22.07
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		Tolfenamic Acid6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
VAL A  28
VAL A 103
LEU A 110
GLY A   1
LEU A 172
1.42A18.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_B_RTLB501_0
(RETINOL DEHYDRATASE)		Vitamin A6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		6 / 12
TYR A  84
LEU A  81
SER A  77
LEU A 147
TYR A 116
ILE A 124
1.69A19.23
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		Digoxin6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		5 / 12
GLN A 115
LEU A 130
GLY A 100
GLU A 161
LEU C   8
1.54A13.31
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_A_PRLA1188_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		Proflavine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 8
HIS A   9
SER A  67
ASN A  70
ILE A  66
1.16A20.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_1
(METHYLTRANSFERASE
NSUN4)		S-Adenosylmethionine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		3 / 3
ASP A 183
ARG A 181
ASP A 238
1.74A21.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRJ_A_RAPA201_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
SERINE/THREONINE-PRO
TEIN KINASE MTOR)		Sirolimus6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		4 / 8
LEU C  10
THR A 138
ASP A 137
TYR A 118
1.28A14.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QL8_B_BEZB143_0
(PUTATIVE REDOX
PROTEIN)		Benzoic Acid6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 6
ARG A  21
THR A  94
ALA A  11
PRO B  32
1.36A17.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM8_A_ACAA511_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		Aminocaproic Acid6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 8
TYR A 123
TYR A  84
TYR A 118
HIS A  93
1.02A24.74
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZ0_B_CLYB900_1
(LINCOSAMIDE
NUCLEOTIDYLTRANSFERA
SE)		Clindamycin6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 8
TYR B  63
GLU A 232
PHE A   8
ILE A  23
1.46A15.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFB_B_ACTB501_0
(METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER)		Acetic acid6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 6
ARG A  48
VAL A  25
ARG A  35
ILE A  23
1.30A23.05
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HUA_A_FK5A201_1
(FK506-BINDING
PROTEIN 1)		Tacrolimus6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 11
PHE A   8
VAL A  25
ILE A  23
LEU A  95
PHE B  62
1.55A19.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		Clarithromycin6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 5
PRO A  43
HIS A   9
LEU B  64
PHE A  33
1.30A20.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNM_A_SAMA401_0
(NSP16 PROTEIN)		S-Adenosylmethionine6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
GLY A 237
GLY A 207
LEU A  32
ASP B  53
ASP A 238
1.67A20.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7U_A_ALEA1001_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		Epinephrine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 6
GLU A  55
PRO A  57
TRP A 167
GLU A  58
1.45A19.77
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		S-Adenosylmethionine6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
TYR A 118
ILE B   1
ARG A  14
SER A  92
HIS A  93
1.45A22.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBY_B_9CRB1500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		Alitretinoin6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
ALA A 140
ALA A 139
GLN A 141
ALA A 135
HIS A  93
1.50A20.70
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_H_LFXH0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		Levofloxacin6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 6
SER B  33
ARG A  82
GLY A  91
GLU A  89
1.37A13.20
15.89
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_A_BEZA1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		Benzoic Acid6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		5 / 10
LEU C   8
LEU C   9
LEU A  95
ARG A  97
TYR A 116
1.49A4.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA8_C_Z80C301_1
(MAJOR PRION PROTEIN)		Chlorpromazine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 5
LEU A 266
GLY A 265
ILE A 213
GLN A 262
1.25A17.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_A_DZPA2001_1
(SERUM ALBUMIN)		Diazepam6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		5 / 12
LEU A  81
TYR A 123
LEU C  10
GLU A 148
LEU A 147
1.64A19.35
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_A_PNXA1435_1
(CHITINASE)		Pentoxifylline6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 6
TYR A  27
GLY B  29
PHE B  62
SER B  61
1.41A20.14
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		S-Adenosylmethionine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		3 / 3
ALA A 211
GLN A 242
THR A 233
1.22A21.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E7F_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		Levomefolic acid6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		5 / 12
GLU A  63
PHE A  33
ASN A  70
LEU C   8
ILE A  66
1.48A21.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		Pemetrexed6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		5 / 12
LEU C   8
ILE A 124
SER A 143
LEU A 147
LEU A 156
1.27A3.56
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Z_L_9CRL501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		Alitretinoin6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
ALA A 140
ALA A 139
GLN A 141
ALA A 135
ILE B   1
1.07A20.42
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NNC_A_ZMRA479_1
(NEURAMINIDASE N9)		Zanamivir6iex MHC CLASS I ANTIGEN
(Homo
sapiens;
SARSr-CoV)		5 / 12
ARG A  97
ARG A  62
GLU C   2
GLU A 163
TYR A  99
1.77A20.95
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3N_A_DLUA398_1
(PFV INTEGRASE)		Dolutegravir6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 8
GLY A  26
PRO A  47
GLU A  46
ARG A 239
1.50A19.80
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_A_SAMA301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		S-Adenosylmethionine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		3 / 3
TYR A 209
THR A  31
GLU A 180
1.61A21.55
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TZU_B_Y70B505_1
(PROTEIN CEREBLON)		Pomalidomide6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 7
HIS A 113
TRP B  60
PHE B  56
THR A 134
1.68A13.24
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_A_SALA601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		Salicylic acid6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 7
LEU A  81
TYR A 123
ILE A 142
GLY A  83
1.35A19.29
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_A_SAMA6734_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		S-Adenosylmethionine6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 12
GLY A 237
ALA B  15
ASN B  24
LEU B  39
PHE B  70
1.62A19.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		Levofloxacin6iex BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 7
ALA A  11
ASP B  53
ARG A  35
GLU A  46
1.24A20.58
22.57
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TPX_E_ACTE204_0
(E3 UBIQUITIN-PROTEIN
LIGASE MDM2)		Acetic acid6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		3 / 3
LYS A 268
PRO A 269
LEU A 270
1.29A15.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLF_A_NVPA999_1
(HIV-1 RT A-CHAIN
HIV-1 RT B-CHAIN)		Nevirapine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 8
LEU A 172
VAL A 103
GLY A 104
GLU A 180
1.18A19.78
20.54
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMA_A_CXXA603_1
(TRANSPORTER)		Clomipramine6iex MHC CLASS I ANTIGEN
(Homo
sapiens)		5 / 11
PRO A 210
ALA A 182
PHE A 208
GLY A 265
THR A 240
1.64A20.08
None