 |
| PDB ID: 6wxd Macromolecule: NSP9 Source Organism: SARS-CoV-2 Gene names: - UniProt ID: P0DTD1 |
SIMILAR PATTERN OF AMINO ACIDS MAPPED TO PDBID '6wxd'
1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.| DrReposER ID / Desc. | Drug | Res. Matches |
View | Interface | RMSD | Seq. Identity (%) |
HETATM | Dock | |
|---|---|---|---|---|---|---|---|---|---|
 Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1I9G_A_SAMA301_0 (HYPOTHETICAL PROTEINRV2118C) | S-Adenosylmethionine | 5 / 12 | GLY A 100GLY A 104SER B 105LEU B 103LEU A 94 | 1.27A | 18.99 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2JT9_A_ACAA7_1 (5-MERIMMUNOSUPPRESSORYPEPTIDE FROMCYCLOLINOPEPTIDE XMODIFIED 16-MERIMMUNOSUPPRESSORYPEPTIDE FROMHOMEOTIC PROTEINANTENNAPEDIA) | Aminocaproic Acid | 4 / 5 | LEU A 29LEU A 45ARG A 10GLN A 11 | 1.13A | 9.308.82 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2YFX_A_VGHA9000_1 (TYROSINE-PROTEINKINASE RECEPTOR) | Crizotinib | 4 / 8 | LEU A 94ALA A 43GLY A 100LEU A 103 | 0.68A | 15.46 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1I9G_A_SAMA301_0 (HYPOTHETICAL PROTEINRV2118C) | S-Adenosylmethionine | 5 / 12 | GLY B 100GLY B 104SER A 105LEU A 103LEU B 94 | 1.26A | 18.99 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4M2X_A_TMQA202_2 (DIHYDROFOLATEREDUCTASE) | Trimetrexate | 3 / 3 | TRP A 53GLN A 49THR A 18 | 1.32A | 22.01 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3KP2_B_PNNB5002_0 (TRANSCRIPTIONALREGULATOR TCAR) | Benzylpenicillin | 4 / 5 | ASN B 27ALA B 16ALA B 15ARG B 55 | 1.02A | 19.73 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4M2X_A_TMQA202_2 (DIHYDROFOLATEREDUCTASE) | Trimetrexate | 3 / 3 | TRP B 53GLN B 49THR B 18 | 1.23A | 22.01 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1A28_A_STRA1_1 (PROGESTERONERECEPTOR) | Progesterone | 5 / 12 | LEU A 45LEU A 29GLN A 11LEU A 112PHE A 90 | 1.23A | 15.08 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3OLS_A_ESTA600_1 (ESTROGEN RECEPTORBETA) | Estradiol | 5 / 12 | MET A 101LEU B 103LEU B 106ALA B 107LEU A 9 | 1.32A | 17.84 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3BOG_C_DVAC10_0 (6.5 KDA GLYCINE-RICHANTIFREEZE PROTEIN) | L-Valine | 3 / 3 | GLY A 104GLY B 100GLY A 100 | 0.75A | 17.70 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4HB6_A_DXCA75_0 (PPCA) | Deoxycholic Acid | 4 / 8 | ILE A 91LEU A 44ILE A 65GLY A 17 | 1.02A | 19.82 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1BX4_A_ADNA350_1 (PROTEIN (ADENOSINEKINASE)) | Adenosine | 5 / 12 | LEU B 112GLY A 100GLY B 100ALA B 107LEU B 106 | 1.27A | 17.74 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2YFX_A_VGHA9000_1 (TYROSINE-PROTEINKINASE RECEPTOR) | Crizotinib | 4 / 8 | LEU B 94ALA B 43GLY B 100LEU B 103 | 0.68A | 15.46 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3PO7_A_ZONA601_1 (AMINE OXIDASE[FLAVIN-CONTAINING]B) | Zonisamide | 4 / 8 | TYR B 31LEU A 4CYH B 73PHE B 75 | 1.27A | 13.16 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4PFJ_A_ADNA502_2 (ADENOSYLHOMOCYSTEINASE) | Adenosine | 4 / 7 | THR A 35LEU A 42ASN A 98SER A 5 | 1.31A | 13.67 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3OZU_A_X89A411_1 (FLAVOHEMOPROTEIN) | Miconazole | 5 / 12 | ALA B 108LEU B 106VAL B 102LEU A 4LEU A 97 | 1.37A | 15.63 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3GCS_A_BAXA401_2 (MITOGEN-ACTIVATEDPROTEIN KINASE 14) | Sorafenib | 4 / 6 | VAL A 41LEU B 103ILE A 65ILE A 91 | 1.25A | 16.92 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ZQ9_A_SAMA4000_1 (PROBABLEDIMETHYLADENOSINETRANSFERASE) | S-Adenosylmethionine | 3 / 3 | GLY B 93GLU B 70ASN B 95 | 1.12A | 16.84 | None |