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| PDB ID: 6iex Macromolecule: MHC CLASS I ANTIGEN Source Organism: Homo sapiens Gene names: HLA-B UniProt ID: F4NBU6 |
SIMILAR PATTERN OF AMINO ACIDS MAPPED TO PDBID '6iex'
1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.| DrReposER ID / Desc. | Drug | Res. Matches |
View | Interface | RMSD | Seq. Identity (%) |
HETATM | Dock | |
|---|---|---|---|---|---|---|---|---|---|
 Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4CPZ_A_ZMRA1471_1 (NEURAMINIDASE) | Zanamivir | 5 / 12 | ARG A 97ARG A 62GLU C 2GLU A 163TYR A 99 | 1.68A | 19.70 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6EMU_A_SAMA501_0 (TRNA(GUANINE(9)-/ADENINE(9)-N1)-METHYLTRANSFERASE) | S-Adenosylmethionine | 5 / 12 | ILE B 46THR B 68ILE B 7VAL B 82ASP B 38 | 1.25A | 20.71 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1DTL_A_BEPA206_1 (CARDIAC TROPONIN C) | Bepridil | 4 / 8 | MET A 5GLU C 2GLU A 55ARG A 48 | 1.55A | 20.53 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4IKI_B_IMNB201_1 (TRANSTHYRETIN) | Indomethacin | 4 / 6 | LEU A 147LEU C 10SER A 77THR A 73 | 1.23A | 19.29 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5E3I_A_HISA502_0 (HISTIDINE--TRNALIGASE) | L-Histidine | 5 / 12 | GLU A 163GLU A 63TYR A 99TYR A 7ALA C 4 | 1.50A | 21.35 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2H42_C_VIAC903_1 (CGMP-SPECIFIC3',5'-CYCLICPHOSPHODIESTERASE) | Sildenafil | 6 / 12 | TYR B 66LEU B 54VAL B 37LEU B 87ILE B 7PHE B 30 | 1.71A | 14.76 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4IFY_A_T27A601_1 (REVERSETRANSCRIPTASE/RIBONUCLEASE H) | Rilpivirine | 5 / 12 | PRO A 235VAL B 82VAL B 9TYR B 66PRO B 5 | 1.48A | 19.18 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3GLQ_A_RABA602_1 (ADENOSYLHOMOCYSTEINASE) | Vidarabine | 5 / 12 | LEU A 168LEU A 110LEU A 109GLY A 112HIS A 113 | 1.52A | 20.27 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ACB_C_DXCC1479_0 (TRANSLATIONELONGATION FACTORSELB) | Deoxycholic Acid | 4 / 5 | THR C 3ILE A 66GLU A 63PHE A 22 | 1.53A | 2.00 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4CPZ_C_ZMRC1470_1 (NEURAMINIDASE) | Zanamivir | 5 / 12 | ARG A 97ARG A 62GLU C 2GLU A 163TYR A 99 | 1.69A | 19.70 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1UWJ_A_BAXA1723_1 (B-RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE) | Sorafenib | 5 / 12 | GLU C 2LEU A 160TRP A 133LEU A 168GLY A 100 | 1.58A | 3.80 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5X23_A_LSNA502_2 (CYTOCHROME P450 2C9) | Losartan | 3 / 3 | LEU A 172VAL A 103ASP A 102 | 0.94A | 17.89 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5M0O_C_EPAC502_1 (TERMINALOLEFIN-FORMING FATTYACID DECARBOXYLASE) | Icosapent | 5 / 8 | LEU B 54PHE B 62ARG A 21ALA A 11PRO B 5 | 1.66A | 12.80 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1UWH_A_BAXA1723_1 (B-RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE) | Sorafenib | 5 / 12 | GLU C 2LEU A 160TRP A 133LEU A 168GLY A 100 | 1.62A | 3.80 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4IP7_D_ADND604_1 (PYRUVATE KINASEISOZYMES L) | Adenosine | 3 / 3 | ARG A 170GLU A 55ASN A 174 | 1.63A | 19.04 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4EQL_A_SALA602_1 (4-SUBSTITUTEDBENZOATES-GLUTAMATELIGASE GH3.12) | Salicylic acid | 4 / 7 | LEU A 81TYR A 123ILE A 142GLY A 83 | 1.35A | 19.29 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5H8T_A_RTLA201_0 (RETINOL-BINDINGPROTEIN 1) | Vitamin A | 5 / 12 | LEU A 126LEU A 147ALA A 153TYR A 159LEU A 109 | 1.56A | 19.31 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3SAN_A_ZMRA901_1 (NEURAMINIDASE) | Zanamivir | 5 / 12 | GLU A 55ALA C 4GLU A 163TYR A 7TYR A 171 | 1.46A | 20.54 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4OR0_B_NPSB603_1 (SERUM ALBUMIN) | Naproxen | 5 / 11 | ARG A 97SER A 77VAL A 152LEU A 147LEU C 9 | 1.58A | 18.60 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5TDZ_A_ADNA905_1 (ATP-CITRATE SYNTHASE) | Adenosine | 4 / 6 | ARG A 239ASP A 177ARG A 181LEU A 179 | 1.57A | 20.27 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3G1U_A_ADNA438_1 (ADENOSYLHOMOCYSTEINASE) | Adenosine | 5 / 12 | LEU A 168LEU A 110LEU A 109GLY A 112HIS A 113 | 1.51A | 21.38 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4NQA_H_9CRH501_1 (RETINOIC ACIDRECEPTOR RXR-ALPHA) | Alitretinoin | 5 / 12 | ALA A 140ALA A 139GLN A 141ALA A 135ILE B 1 | 0.94A | 22.45 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4R29_D_SAMD301_1 (UNCHARACTERIZEDPROTEIN) | S-Adenosylmethionine | 3 / 3 | ARG A 256GLU A 222TYR A 257 | 1.06A | 19.78 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ZUC_A_T98A201_1 (PROGESTERONERECEPTOR) | Tanaproget | 5 / 10 | LEU C 8ASN A 70GLN A 72LEU C 10TYR A 116 | 1.72A | 5.88 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5UC3_A_486A801_1 (GLUCOCORTICOIDRECEPTOR) | Mifepristone | 5 / 12 | ASN A 174GLY A 175PHE A 33MET A 5LEU A 168 | 1.54A | 21.02 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4QWU_K_BO2K301_1 (PROTEASOME SUBUNITBETA TYPE-5PROTEASOME SUBUNITBETA TYPE-6) | Bortezomib | 5 / 9 | THR A 258THR A 216ALA A 245GLY A 221ASP A 227 | 1.70A | 19.4320.35 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6GBN_C_ADNC501_2 (-) | Adenosine | 4 / 5 | GLN A 242THR A 233THR A 31GLY A 207 | 1.42A | 19.64 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4J7X_B_SASB804_2 (SEPIAPTERINREDUCTASE) | Sulfasalazine | 3 / 3 | LEU A 168MET A 5ASP A 177 | 1.16A | 20.13 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4LG1_A_SAMA301_0 (PROTEIN-LYSINEMETHYLTRANSFERASEMETTL21D) | S-Adenosylmethionine | 5 / 12 | GLY A 112LEU A 156LEU A 160TRP A 133TYR A 116 | 1.32A | 22.61 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5JMN_A_FUAA1101_1 (MULTIDRUG EFFLUXPUMP SUBUNIT ACRB) | Fusidic Acid | 4 / 5 | ILE A 52LYS A 176HIS A 3VAL A 28 | 1.78A | 13.61 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5M66_D_ADND502_2 (ADENOSYLHOMOCYSTEINASE) | Adenosine | 3 / 3 | THR A 71THR A 94LEU B 54 | 0.70A | 18.67 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6CGD_A_AKNA600_1 (BIFUNCTIONAL AAC/APH) | Amikacin | 5 / 10 | GLY A 162TYR A 159TYR A 171VAL A 34GLU C 2 | 1.71A | 19.38 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3TIC_B_ZMRB1002_1 (NEURAMINIDASE) | Zanamivir | 5 / 12 | ARG A 97ARG A 62GLU C 2GLU A 163TYR A 99 | 1.76A | 20.39 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3THR_A_C2FA1100_0 (GLYCINEN-METHYLTRANSFERASE) | Levomefolic acid | 4 / 6 | SER A 38HIS A 9THR A 71ARG A 75 | 1.76A | 23.21 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5IKT_A_TLFA601_1 (PROSTAGLANDIN G/HSYNTHASE 2) | Tolfenamic Acid | 3 / 3 | LEU A 147TYR A 116SER A 77 | 0.93A | 18.81 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6A5Z_D_9CRD501_0 (RETINOIC ACIDRECEPTOR RXR-ALPHA) | Alitretinoin | 5 / 12 | ALA A 140ALA A 139GLN A 141ALA A 135ILE B 1 | 1.08A | 20.42 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2OXT_B_SAMB300_1 (NUCLEOSIDE-2'-O-METHYLTRANSFERASE) | S-Adenosylmethionine | 4 / 5 | SER A 13GLY A 91HIS B 84ASP A 119 | 1.57A | 21.03 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1I9G_A_SAMA301_1 (HYPOTHETICAL PROTEINRV2118C) | S-Adenosylmethionine | 3 / 3 | GLU A 264HIS A 263ASP A 30 | 1.55A | 22.61 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1FBY_A_9CRA500_1 (RETINOIC ACIDRECEPTOR RXR-ALPHA) | Alitretinoin | 5 / 12 | ALA A 140ALA A 139GLN A 141ALA A 135HIS A 93 | 1.49A | 20.70 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5XIW_B_LOCB504_1 (TUBULIN ALPHA-1BCHAINTUBULIN BETA CHAIN) | Colchicine | 3 / 3 | SER A 132ALA A 153VAL A 152 | 0.92A | 21.15 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3VAQ_A_ADNA401_1 (PUTATIVE ADENOSINEKINASE) | Adenosine | 6 / 12 | ASN A 114LEU C 5GLY A 100THR C 3LEU A 156GLY A 26 | 1.54A | 21.11 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5CDQ_F_MFXF2101_1 (DNA GYRASE SUBUNIT ADNA GYRASE SUBUNITB,DNA GYRASE SUBUNITB) | Moxifloxacin | 4 / 6 | ARG A 273ARG A 219GLY A 221GLU A 222 | 1.49A | 20.2521.07 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4XO7_A_ASDA402_1 (ALDO-KETO REDUCTASEFAMILY 1 MEMBER C2) | 4-Androstenedione | 4 / 7 | TYR A 99VAL A 34ILE A 52LEU A 168 | 1.38A | 20.66 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6F32_B_ACTB602_0 (AMINE OXIDASE LKCE) | Acetic acid | 4 / 6 | ASN A 114TYR A 99VAL A 152THR C 3 | 1.74A | 20.40 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1XVA_B_SAMB293_0 (GLYCINEN-METHYLTRANSFERASE) | S-Adenosylmethionine | 5 / 12 | ASN A 70SER A 67TYR A 159TYR A 116TYR A 74 | 1.79A | 22.99 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1TH6_A_OINA401_1 (PHOSPHOLIPASE A2) | Hyoscyamine | 4 / 7 | GLY A 26HIS A 9TYR A 99LYS C 1 | 1.38A | 16.36 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5YJ1_G_6ELG501_0 (PROTEIN CEREBLON) | Thalidomide | 4 / 8 | HIS A 113TRP B 60PHE B 56THR A 134 | 1.72A | 13.55 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6R2E_H_FFOH403_0 (THYMIDYLATE SYNTHASE) | Levoleucovorin | 5 / 12 | TYR A 99LEU A 156LEU C 9ASN A 70ALA A 150 | 1.31A | 24.15 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4MI4_B_SPMB201_1 (SPERMIDINEN1-ACETYLTRANSFERASE) | Spermine | 4 / 7 | GLU A 53GLU A 55TYR A 171ARG A 170 | 1.62A | 19.79 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4IAQ_A_2GMA2001_2 (CHIMERA PROTEIN OFHUMAN5-HYDROXYTRYPTAMINERECEPTOR 1B AND E.COLI SOLUBLECYTOCHROME B562) | Dihydroergotamine | 4 / 6 | ILE A 23THR A 24SER A 38ASP A 119 | 1.43A | 19.36 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6EMU_B_SAMB301_0 (TRNA(GUANINE(9)-/ADENINE(9)-N1)-METHYLTRANSFERASE) | S-Adenosylmethionine | 5 / 12 | ILE B 46THR B 68ILE B 7VAL B 82ASP B 38 | 1.15A | 20.71 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1OSV_B_CHCB201_2 (BILE ACID RECEPTOR) | Obeticholic acid | 4 / 5 | HIS A 93ARG A 82ILE A 23HIS B 31 | 1.61A | 20.07 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3UQ6_B_ADNB401_1 (ADENOSINE KINASE,PUTATIVE) | Adenosine | 7 / 12 | ASN A 114ILE A 66LEU C 5GLY A 100THR C 3LEU A 156GLY A 26 | 1.74A | 21.11 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ERR_B_RALB600_1 (ESTROGEN RECEPTOR) | Raloxifene | 6 / 12 | GLU A 163LEU A 160ARG A 62LEU C 8LEU A 126LEU A 130 | 1.75A | 20.62 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2FCN_B_DVAB35_0 (UBIQUITIN) | L-Valine | 4 / 6 | LEU A 201GLU A 198ILE A 194PRO A 193 | 1.66A | 13.87 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4KT0_A_PQNA2001_1 (PHOTOSYSTEM I P700CHLOROPHYLL AAPOPROTEIN A1PHOTOSYSTEM IREACTION CENTERSUBUNIT IX) | Phylloquinone | 5 / 11 | SER A 92GLY A 91ARG A 82LEU A 78ILE A 66 | 1.33A | 14.719.06 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5YNI_A_SAMA401_0 (NSP16 PROTEIN) | S-Adenosylmethionine | 5 / 12 | GLY A 237GLY A 207LEU A 32ASP B 53ASP A 238 | 1.69A | 20.24 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3BGD_A_PM6A301_1 (THIOPURINES-METHYLTRANSFERASE) | Mercaptopurine | 4 / 6 | GLY A 237ALA A 236LEU B 65PRO A 235 | 1.54A | 21.48 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4X20_D_LOCD502_1 (TUBULIN ALPHA CHAINTUBULIN BETA CHAIN) | Colchicine | 3 / 3 | SER A 132ALA A 153VAL A 152 | 0.98A | 21.15 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3CJT_K_SAMK302_0 (RIBOSOMAL PROTEINL11METHYLTRANSFERASE) | S-Adenosylmethionine | 5 / 12 | HIS B 31LEU A 81ILE A 124SER A 143LEU A 95 | 1.29A | 14.57 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5EF8_A_LBHA2004_1 (HDAC6 PROTEIN) | Panobinostat | 5 / 12 | PRO A 43SER A 67PHE A 36PHE A 22ASP A 39 | 1.71A | 20.98 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2A3B_B_CFFB2434_1 (CHITINASE) | Caffeine | 4 / 6 | TRP A 167GLU A 163TYR A 159PHE A 33 | 1.72A | 20.14 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3K9F_F_LFXF0_1 (DNA TOPOISOMERASE 4SUBUNIT ADNA TOPOISOMERASE 4SUBUNIT B) | Levofloxacin | 4 / 5 | SER B 33ARG A 82GLY A 91GLU A 89 | 1.37A | 13.2015.89 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1HK3_A_T44A3002_1 (SERUM ALBUMIN) | Levothyroxine | 4 / 8 | GLN A 115ASN A 114LEU A 160ARG A 111 | 1.34A | 19.35 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1GAH_A_ACRA497_1 (GLUCOAMYLASE-471) | Acarbose | 5 / 12 | TYR A 59GLY A 162GLU A 163TYR A 7GLU A 63 | 1.57A | 20.25 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3T3S_C_9PLC1_1 (CYTOCHROME P450 2A13) | Pilocarpine | 4 / 7 | PHE A 33ALA A 49THR A 31LEU A 179 | 1.26A | 18.75 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1MZ9_D_VDYD1001_5 (CARTILAGE OLIGOMERICMATRIX PROTEIN) | Calcidiol | 3 / 3 | THR A 228LEU A 230VAL A 231 | 0.88A | 12.16 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4XJE_A_TOYA202_1 (AADB) | Tobramycin | 4 / 8 | ASP B 53GLU C 2ILE A 66TYR A 74 | 1.51A | 18.44 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5MQT_A_STIA302_1 (DEOXYCYTIDINE KINASE) | Imatinib | 5 / 12 | ILE A 66TYR A 99GLU A 161GLN A 155GLU C 2 | 1.69A | 21.12 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4J03_A_FVSA603_1 (BIFUNCTIONAL EPOXIDEHYDROLASE 2) | Fulvestrant | 5 / 12 | ILE A 52TYR A 159LEU C 8LEU A 156HIS A 9 | 1.21A | 18.63 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2CML_B_ZMRB2477_1 (NEURAMINIDASE) | Zanamivir | 5 / 12 | ARG A 97ARG A 62GLU C 2GLU A 163TYR A 99 | 1.72A | 19.14 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2OA1_A_TRPA2003_0 (TRYPTOPHANHALOGENASE) | L-Tryptophan | 5 / 12 | PRO A 43ILE A 66PHE A 36GLU A 63TRP A 60 | 1.79A | 20.40 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6MN4_A_AM2A301_0 (AMINOGLYCOSIDEN(3)-ACETYLTRANSFERASE, AAC(3)-IVA) | Apramycin | 4 / 8 | ASP A 196HIS A 191HIS A 197GLU A 254 | 1.44A | 21.00 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3OZK_B_T44B128_1 (TRANSTHYRETIN) | Levothyroxine | 4 / 7 | LEU A 147LEU C 10SER A 77THR A 73 | 1.24A | 18.91 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ZQ9_B_SAMB4001_0 (PROBABLEDIMETHYLADENOSINETRANSFERASE) | S-Adenosylmethionine | 5 / 12 | LEU C 8LEU C 7ASN A 80LEU C 10ILE A 124 | 1.25A | 3.28 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4KCN_B_MTLB806_0 (NITRIC OXIDESYNTHASE, BRAIN) | Mannitol | 4 / 7 | GLN A 96PHE A 8ASN A 114TRP B 60 | 1.52A | 20.70 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5NOO_D_D16D402_1 (THYMIDYLATE SYNTHASE) | Raltitrexed | 5 / 8 | ARG A 169TYR A 171ILE A 52LEU A 179GLY A 175 | 1.46A | None | |||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4IFV_A_T27A601_1 (EXORIBONUCLEASE H,P66 RT) | Rilpivirine | 5 / 12 | PRO A 235VAL B 82VAL B 9TYR B 66PRO B 5 | 1.46A | 19.18 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1MRJ_A_ADNA300_1 (ALPHA-TRICHOSANTHIN) | Adenosine | 4 / 8 | GLY A 175TYR A 171ILE A 52GLU A 55 | 1.36A | 22.81 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3RC0_B_SAMB480_0 (N-LYSINEMETHYLTRANSFERASESETD6) | S-Adenosylmethionine | 5 / 12 | GLY A 237ALA B 15ASN B 24LEU B 39PHE B 70 | 1.63A | 19.61 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4M11_D_MXMD606_1 (PROSTAGLANDIN G/HSYNTHASE 2) | Meloxicam | 5 / 12 | ILE A 213VAL A 261LEU A 270LEU A 215LEU A 206 | 1.47A | 17.89 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1NBH_B_SAMB1293_0 (GLYCINEN-METHYLTRANSFERASE) | S-Adenosylmethionine | 5 / 12 | ILE A 52VAL A 34MET A 5LEU C 5TYR A 59 | 1.36A | 22.99 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4Y03_B_SALB801_1 (PROTEIN POLYBROMO-1) | Salicylic acid | 4 / 5 | LEU A 156ALA C 6ASN A 70ILE A 66 | 1.46A | 19.33 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ZO1_X_T3X500_1 (THYROID HORMONERECEPTOR BETA) | Liothyronine | 5 / 12 | ILE A 124ARG A 97ALA A 153LEU A 126ASN A 114 | 1.58A | 22.89 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4XR4_B_AG2B511_1 (HOMOSPERMIDINESYNTHASE) | Agmatine | 3 / 3 | VAL A 34PHE A 36ARG A 44 | 1.61A | 21.74 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ETB_1_T441128_1 (TRANSTHYRETIN) | Levothyroxine | 4 / 6 | LEU A 160GLU A 163ALA A 158LEU A 130 | 1.09A | 19.93 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1KQE_A_DVAA6_0 (MINI-GRAMICIDIN A) | L-Valine | 3 / 3 | ALA A 149VAL A 152TRP A 133 | 1.31A | 24.14 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6A5Y_D_9CRD501_0 (RETINOIC ACIDRECEPTOR RXR-ALPHA) | Alitretinoin | 5 / 12 | ALA A 140ALA A 139GLN A 141ALA A 135ILE B 1 | 1.26A | 20.42 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3OZU_A_X89A411_1 (FLAVOHEMOPROTEIN) | Miconazole | 6 / 12 | ALA A 125LEU A 126HIS A 9LEU A 160TYR A 159LEU C 5 | 1.40A | 18.29 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4MWR_A_ZMRA513_1 (NEURAMINIDASE) | Zanamivir | 5 / 12 | ARG A 97ARG A 62GLU C 2GLU A 163TYR A 99 | 1.74A | 20.66 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3PS9_A_SAMA670_1 (TRNA5-METHYLAMINOMETHYL-2-THIOURIDINEBIOSYNTHESISBIFUNCTIONAL PROTEINMNMC) | S-Adenosylmethionine | 4 / 6 | TYR A 7GLY C 1LEU A 168GLU A 63 | 1.44A | 19.04 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4JQ4_B_IMNB401_1 (ALDO-KETO REDUCTASEFAMILY 1 MEMBER C2) | Indomethacin | 5 / 10 | HIS A 9ILE A 124ASN A 70LEU C 5LEU C 8 | 1.60A | 20.68 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5YF0_A_SAMA505_0 (CARNOSINEN-METHYLTRANSFERASE) | S-Adenosylmethionine | 5 / 12 | SER B 33MET A 12PHE A 8PHE A 36TYR A 27 | 1.76A | 14.16 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5X24_A_LSNA502_1 (CYTOCHROME P450 2C9) | Losartan | 5 / 12 | ALA A 49LEU A 32VAL A 28MET A 5GLY C 1 | 1.49A | 17.89 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5L6E_B_ACTB401_0 (N6-ADENOSINE-METHYLTRANSFERASE 70 KDASUBUNITN6-ADENOSINE-METHYLTRANSFERASE SUBUNITMETTL14) | Acetic acid | 4 / 6 | GLU A 19ARG A 75LEU A 78ARG A 79 | 1.27A | 23.4521.20 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3N62_A_MTLA870_0 (NITRIC OXIDESYNTHASE) | Mannitol | 4 / 8 | GLN A 96PHE A 8ASN A 114TRP B 60 | 1.58A | 20.05 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4XMF_A_HSMA202_1 (NITROPHORIN-7) | Histamine | 3 / 3 | ASP A 238LEU A 206GLY A 207 | 0.88A | 22.68 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2J2P_B_SC2B1294_1 (FICOLIN-2) | Acetylcysteine | 5 / 9 | GLY A 100LEU A 126LEU A 130ASP A 102GLU A 128 | 1.71A | 20.15 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5Y2O_A_8N6A501_1 (PEROXISOMEPROLIFERATOR-ACTIVATED RECEPTOR GAMMA) | Pioglitazone | 5 / 12 | PHE A 22SER A 77LEU C 7LEU A 95TYR A 116 | 1.74A | 21.79 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4XJ7_A_ADNA303_1 (5'/3'-NUCLEOTIDASESURE) | Adenosine | 5 / 10 | ALA A 139ILE A 124LEU C 10LEU A 147TYR A 123 | 1.60A | 24.67 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4A7T_A_5FWA1000_1 (SUPEROXIDE DISMUTASE[CU-ZN]) | Isoprenaline | 4 / 6 | GLU A 55PRO A 57TRP A 167GLU A 58 | 1.46A | 19.77 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3E22_B_LOCB700_1 (TUBULIN ALPHA-1CCHAINTUBULIN BETA-2BCHAIN) | Colchicine | 3 / 3 | SER A 132ALA A 153VAL A 152 | 1.16A | 20.60 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1HTT_C_HISC450_0 (HISTIDYL-TRNASYNTHETASE) | L-Histidine | 5 / 12 | GLU A 163GLU A 63TYR A 99TYR A 7ALA C 4 | 1.55A | 22.40 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1I7Z_A_COCA301_1 (CHIMERA OF IG KAPPACHAIN: HUMANCONSTANT REGION ANDMOUSE VARIABLEREGION) | Cocaine | 4 / 8 | LEU A 168LEU A 110SER A 2GLU A 180 | 1.49A | 24.62 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2VDM_B_AGGB1462_1 (INTEGRIN ALPHA-IIBINTEGRIN BETA-3) | Tirofiban | 5 / 12 | PHE A 22TYR A 74LEU A 78TYR A 7ASN A 114 | 1.63A | 22.8018.71 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2AJV_L_COCL501_1 (ANTIBODY 7A1 FAB') | Cocaine | 5 / 7 | TYR A 74ARG A 97TYR A 123TYR A 84TYR A 85 | 1.70A | 21.0021.60 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4FP9_A_SAMA401_1 (METHYLTRANSFERASENSUN4) | S-Adenosylmethionine | 3 / 3 | ASP A 183ARG A 181ASP A 30 | 1.39A | 21.35 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4A97_C_ZPCC1318_1 (CYS-LOOPLIGAND-GATED IONCHANNEL) | Eszopiclone | 5 / 12 | GLU A 63ILE A 66GLU C 2TYR A 99VAL A 103 | 1.62A | 21.65 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1HK1_A_T44A3003_1 (SERUM ALBUMIN) | Levothyroxine | 4 / 6 | ILE A 213LYS A 243ALA A 245VAL A 261 | 1.73A | 19.35 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1STF_E_CCSE25_0 (PAPAINSTEFIN B (CYSTATINB)) | Carbocisteine | 5 / 10 | SER B 20PHE B 22SER B 11ALA B 15GLY B 18 | 1.44A | 15.5725.22 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1OHR_A_1UNA201_1 (ASPARTYLPROTEASE) | Nelfinavir | 5 / 11 | GLY B 29ASP B 59GLY A 120ILE B 1THR A 10 | 1.44A | 17.24 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ACL_C_REAC503_1 (RETINOIC ACIDRECEPTOR RXR-ALPHA) | Tretinoin | 5 / 10 | ALA A 140ALA A 139GLN A 141ALA A 135ILE B 1 | 1.05A | 20.42 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3G1U_B_ADNB438_1 (ADENOSYLHOMOCYSTEINASE) | Adenosine | 5 / 12 | LEU A 78HIS A 93THR A 94GLN A 96GLY A 120 | 1.74A | 21.38 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1FML_A_RTLA401_0 (RETINOL DEHYDRATASE) | Vitamin A | 5 / 12 | LEU C 10LEU C 8HIS B 31TYR A 123ILE A 124 | 1.51A | 1.99 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3V35_A_NTIA317_1 (ALDOSE REDUCTASE) | Nitazoxanide | 4 / 8 | VAL A 28TRP A 167PRO A 47TRP A 60 | 1.70A | 20.69 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4A97_H_ZPCH1318_2 (CYS-LOOPLIGAND-GATED IONCHANNEL) | Eszopiclone | 4 / 7 | GLU A 63ILE A 66TYR A 159VAL A 103 | 1.42A | 21.65 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6FGD_A_ACTA807_0 (GEPHYRIN) | Acetic acid | 4 / 4 | PRO B 90LEU B 87VAL B 37ARG B 81 | 1.43A | 13.54 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3UT5_B_LOCB502_1 (TUBULIN BETA CHAIN) | Colchicine | 5 / 12 | ALA A 139LEU A 81THR A 94ILE A 124LYS A 121 | 1.55A | 18.44 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5A1I_A_SAMA405_0 (S-ADENOSYLMETHIONINESYNTHASE ISOFORMTYPE-2) | S-Adenosylmethionine | 4 / 7 | LYS B 58SER B 55PHE A 8ASP A 30 | 1.73A | 12.56 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6AG0_A_ACRA605_0 (ALPHA-AMYLASE) | Acarbose | 4 / 8 | TYR A 123GLY A 120ILE B 1ASP A 122 | 1.43A | 19.23 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4L9Q_B_9TPB601_1 (SERUM ALBUMIN) | Teniposide | 5 / 12 | LEU A 81TYR A 116ILE A 124LEU C 8LYS A 146 | 1.48A | 19.35 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4M7T_A_SAMA503_0 (BTRN) | S-Adenosylmethionine | 5 / 11 | TYR A 27GLU C 2THR A 10LEU B 54LEU B 64 | 1.68A | 21.58 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1SN5_C_T3C601_1 (TRANSTHYRETIN) | Liothyronine | 4 / 6 | LEU A 160GLU A 163ALA A 158LEU A 130 | 1.16A | 19.46 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5WM2_A_ACTA605_0 (SALICYLATE-AMPLIGASE) | Acetic acid | 3 / 3 | THR A 271THR A 258ARG A 273 | 1.55A | 20.68 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2E7F_B_C2FB4000_0 (5-METHYLTETRAHYDROFOLATE CORRINOID/IRONSULFUR PROTEINMETHYLTRANSFERASE) | Levomefolic acid | 5 / 12 | GLU A 63PHE A 33ASN A 70LEU C 8ILE A 66 | 1.50A | 21.64 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5CDN_G_EVPG2101_1 (DNA GYRASE SUBUNIT ADNA GYRASE SUBUNITB,DNA GYRASE SUBUNITB) | Etoposide | 4 / 6 | SER A 88GLY A 18ARG A 17GLY A 16 | 1.38A | 20.2521.15 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6DRY_A_H8DA2001_0 (5HT2B RECEPTOR, BRILCHIMERA) | Methylergometrine | 5 / 11 | ASP A 29VAL A 28LEU A 172ALA A 49TYR A 209 | 1.57A | 19.42 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5EML_A_SAMA701_0 (PROTEIN ARGININEN-METHYLTRANSFERASE5) | S-Adenosylmethionine | 5 / 12 | GLY A 100LEU A 168ASN A 114ARG A 157LEU A 109 | 1.61A | 17.16 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2XKK_E_MFXE1100_1 (TOPOISOMERASE IVDNA) | Moxifloxacin | 3 / 3 | ARG A 21GLU C 2SER B 33 | 1.41A | 16.12 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3V4T_H_ACTH503_0 (UDP-N-ACETYLGLUCOSAMINE1-CARBOXYVINYLTRANSFERASE) | Acetic acid | 4 / 7 | ALA A 205ILE A 213ARG A 234GLY A 207 | 1.59A | 22.95 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5KKZ_E_ASCE1004_0 (CYTOCHROME BUBIQUINOL-CYTOCHROMEC REDUCTASEIRON-SULFUR SUBUNIT) | Vitamin C | 4 / 7 | HIS A 9ILE A 66TYR A 99ARG A 97 | 1.38A | 20.8518.97 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5KF8_A_GCSA404_1 (PREDICTEDACETYLTRANSFERASE) | Glucosamine | 4 / 8 | ARG A 82PRO A 20GLY A 16PRO A 15 | 1.53A | 20.59 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6R2E_E_FFOE403_0 (THYMIDYLATE SYNTHASE) | Levoleucovorin | 5 / 12 | TYR A 99LEU A 156LEU C 9ASN A 70ALA A 150 | 1.34A | 24.15 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3MIY_A_B49A1_1 (TYROSINE-PROTEINKINASE ITK/TSK) | Sunitinib | 5 / 11 | ALA A 49VAL A 28PHE A 33GLY A 175LEU A 179 | 1.57A | 20.13 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1VPT_A_SAMA400_1 (VP39) | S-Adenosylmethionine | 3 / 3 | ASP A 183ARG A 181ASP A 238 | 1.48A | 19.83 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4UYM_B_VORB590_1 (14-ALPHA STEROLDEMETHYLASE) | Voriconazole | 4 / 7 | TYR A 74ALA A 117ILE A 124LEU A 81 | 1.24A | 20.13 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1C8L_A_CFFA940_1 (PROTEIN (GLYCOGENPHOSPHORYLASE)) | Caffeine | 5 / 6 | ASN B 24PHE B 22HIS B 13ALA A 236GLY A 237 | 1.79A | 7.87 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3FPJ_B_SAMB301_1 (PUTATIVEUNCHARACTERIZEDPROTEIN) | S-Adenosylmethionine | 4 / 7 | GLY A 162THR C 3GLU A 166ALA A 158 | 1.01A | 23.89 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4BLV_A_SAMA1281_1 (RIBOSOMAL RNA LARGESUBUNITMETHYLTRANSFERASE J) | S-Adenosylmethionine | 4 / 6 | HIS A 192HIS A 188GLU A 229ASP A 227 | 1.62A | 24.84 | None | ||
 Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3VRJ_A_1KXA301_1 (HLA CLASS IHISTOCOMPATIBILITYANTIGEN, B-57 ALPHACHAIN10-MER PEPTIDE) | Abacavir | 5 / 12 | TYR A 74TYR A 99TYR A 123ILE A 124THR C 3 | 0.45A | 89.0523.81 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ZZM_A_SAMA401_1 (UNCHARACTERIZEDPROTEIN MJ0883) | S-Adenosylmethionine | 3 / 3 | ARG A 234ASP A 238ASN B 24 | 1.35A | 21.63 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6J20_A_GBQA1201_1 (SUBSTANCE-PRECEPTOR,ENDOLYSIN) | Aprepitant | 4 / 7 | ILE B 7GLU B 36HIS B 84VAL B 27 | 1.24A | 11.90 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3U5J_A_08HA1_1 (BROMODOMAIN-CONTAINING PROTEIN 4) | Alprazolam | 4 / 7 | LEU C 5LEU C 8ASN A 70ILE A 66 | 1.41A | 5.98 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1XL6_B_SPMB3001_1 (INWARD RECTIFIERPOTASSIUM CHANNEL) | Spermine | 4 / 5 | ALA A 140TYR A 118ALA A 136GLN A 96 | 1.35A | 22.26 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5DZ2_A_212A404_1 (GERMACRADIENOL/GEOSMIN SYNTHASE) | Alendronic acid | 5 / 9 | VAL A 152ASN A 70GLU C 2ARG A 97TYR A 74 | 1.66A | 20.63 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4M5M_A_DX4A401_0 (2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDINEPYROPHOSPHOKINASE) | Tioguanine | 4 / 8 | THR A 73LEU C 8TYR A 74ASN A 70 | 1.38A | 22.84 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6EW0_G_TA1G501_1 (TUBULIN BETA CHAIN) | Paclitaxel | 5 / 12 | GLU A 166LEU A 126ALA A 158LEU A 130LEU A 109 | 1.52A | 19.46 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2WV2_A_TPFA1_1 (LANOSTEROL14-ALPHA-DEMETHYLASE) | Fluconazole | 5 / 9 | TYR A 99TYR A 7ALA C 4ALA C 6THR A 73 | 1.76A | 19.44 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2CML_D_ZMRD4477_1 (NEURAMINIDASE) | Zanamivir | 5 / 12 | ARG A 97ARG A 62GLU C 2GLU A 163TYR A 99 | 1.75A | 19.14 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2B25_B_SAMB602_1 (HYPOTHETICAL PROTEIN) | S-Adenosylmethionine | 3 / 3 | GLY A 175GLU A 173ASP A 177 | 1.44A | 21.26 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1DF7_A_MTXA501_2 (DIHYDROFOLATEREDUCTASE) | Methotrexate | 3 / 3 | TRP A 167ARG A 157THR C 3 | 1.26A | 21.86 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3G1U_D_ADND438_1 (ADENOSYLHOMOCYSTEINASE) | Adenosine | 5 / 12 | LEU A 168LEU A 110LEU A 109GLY A 112HIS A 113 | 1.49A | 21.38 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2NO0_A_GEOA302_1 (DEOXYCYTIDINE KINASE) | Gemcitabine | 5 / 12 | ILE A 66GLU A 163MET A 5TYR A 7ARG A 62 | 1.78A | 20.71 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1MRQ_A_STRA501_1 (ALDO-KETO REDUCTASEFAMILY 1 MEMBER C1) | Progesterone | 5 / 11 | VAL A 34ILE A 52GLU A 163TRP A 167LEU A 168 | 1.46A | 21.07 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6DJZ_A_GMJA301_0 (SIGMA NON-OPIOIDINTRACELLULARRECEPTOR 1) | Haloperidol | 5 / 12 | TYR A 159PHE A 33VAL A 28VAL A 34LEU C 5 | 1.47A | 24.21 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4QMS_A_1N1A401_1 (SERINE/THREONINE-PROTEIN KINASE 24) | Dasatinib | 5 / 11 | ILE A 52TYR A 171LEU A 172LEU A 179ASP A 177 | 1.62A | 19.63 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2J9C_A_ACTA1122_0 (HYPOTHETICALNITROGEN REGULATORYPII-LIKE PROTEINMJ0059) | Acetic acid | 4 / 7 | SER B 28LYS B 6SER B 57SER B 61 | 1.48A | 17.95 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6EW0_F_TA1F502_1 (TUBULIN BETA CHAIN) | Paclitaxel | 5 / 12 | GLU A 166LEU A 126ALA A 158LEU A 130LEU A 109 | 1.52A | 19.46 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5BTD_E_GFNE101_1 (DNA GYRASE SUBUNIT ADNA GYRASE SUBUNIT BDNA SUBSTRATE 24-MERGGTCATGAATGACTATGCACGTAA) | Gatifloxacin | 4 / 7 | ALA A 11ASP B 53ARG A 35GLU A 46 | 1.29A | 20.5822.57 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2QO6_A_CHDA130_0 (LIVER-BASIC FATTYACID BINDING PROTEIN) | Cholic Acid | 5 / 12 | TYR A 85LEU A 81LEU C 10ALA A 140HIS B 31 | 1.44A | 17.31 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4KFB_A_T27A607_1 (REVERSETRANSCRIPTASE/RIBONUCLEASE H,EXORIBONUCLEA P66 RT) | Rilpivirine | 5 / 12 | PRO A 235VAL B 82VAL B 9TYR B 66PRO B 5 | 1.46A | 19.18 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3EL0_A_1UNA201_1 (PROTEASE) | Nelfinavir | 4 / 8 | ALA A 40ASP A 39ASP A 37THR A 64 | 1.06A | 17.69 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4U15_B_0HKB1201_1 (MUSCARINICACETYLCHOLINERECEPTORM3,LYSOZYME,MUSCARINIC ACETYLCHOLINERECEPTOR M3) | Tiotropium | 5 / 12 | SER B 52THR A 240ALA A 236TYR B 26TYR B 63 | 1.77A | 12.10 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5HWA_A_GCSA303_1 (CHITOSANASE) | Glucosamine | 4 / 5 | ASP A 223HIS A 260VAL A 247ALA A 245 | 1.35A | 20.36 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3H5G_B_LEIB16_0 (COIL SER L16D-PEN) | Penicillamine | 4 / 5 | LEU C 9GLN A 72LEU C 7GLU A 76 | 1.71A | 29.63 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3B6R_B_CRNB603_1 (CREATINE KINASEB-TYPE) | Creatine | 4 / 6 | THR A 190VAL A 189LEU A 201GLU A 254 | 1.69A | 20.62 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3JB3_A_SAMA1101_0 (STRUCTURAL PROTEINVP3) | S-Adenosylmethionine | 5 / 12 | SER A 92MET A 12VAL B 27ASP B 34ILE B 35 | 1.69A | 13.13 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5IGI_A_ZITA402_2 (MACROLIDE2'-PHOSPHOTRANSFERASE) | Azithromycin | 4 / 6 | PRO B 14GLU A 232ALA A 245LEU A 215 | 1.46A | 14.62 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3V2M_A_AZMA303_1 (CARBONIC ANHYDRASE 2) | Acetazolamide | 5 / 10 | HIS A 192VAL A 189LEU A 201THR A 200TRP A 274 | 1.69A | 21.02 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3SUF_B_SUEB1201_2 (NS3 PROTEASE, NS4APROTEIN) | Grazoprevir | 3 / 3 | TYR A 27LEU A 156ARG A 6 | 1.68A | 22.83 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5YCP_A_BRLA501_0 (PEROXISOMEPROLIFERATOR-ACTIVATED RECEPTOR GAMMA) | Rosiglitazone | 5 / 12 | PHE A 22SER A 77LEU C 7LEU A 95TYR A 116 | 1.62A | 21.23 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1IE4_B_T44B328_1 (TRANSTHYRETIN) | Levothyroxine | 4 / 8 | LEU A 272LYS A 243ALA A 205THR A 187 | 1.06A | 17.60 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6BEO_A_DHIA4_0 ((DPR)PY(DHI)PKDL(DGN)) | L-Histidine | 3 / 3 | TYR B 63PRO A 235LEU B 65 | 1.49A | 10.59 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4R38_C_RBFC201_2 (BLUE-LIGHT-ACTIVATEDHISTIDINE KINASE 2) | Riboflavin | 5 / 9 | ILE A 52GLU A 55ASN A 174LEU A 168PHE A 33 | 1.40A | 18.71 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3Q5S_A_ACHA1289_0 (MULTIDRUG-EFFLUXTRANSPORTER 1REGULATOR) | Acetylcholine | 4 / 6 | VAL A 34TYR A 59GLU C 2ILE A 66 | 1.50A | 23.35 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1XDK_E_9CRE1500_1 (RETINOIC ACIDRECEPTOR RXR-ALPHA) | Alitretinoin | 5 / 12 | ILE A 124ALA A 140ALA A 135GLN A 141ARG A 145 | 1.49A | 20.42 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3V4T_C_ACTC502_0 (UDP-N-ACETYLGLUCOSAMINE1-CARBOXYVINYLTRANSFERASE) | Acetic acid | 3 / 3 | PRO A 210ASP A 30GLU A 212 | 1.09A | 22.95 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4HVR_A_SALA203_1 (3-HYDROXYANTHRANILATE 3,4-DIOXYGENASE) | Salicylic acid | 4 / 7 | GLU C 2HIS A 9VAL A 34GLU A 63 | 1.33A | 6.74 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3RGF_A_BAXA465_1 (CYCLIN-DEPENDENTKINASE 8) | Sorafenib | 5 / 12 | ALA A 139LEU A 147ILE A 124ALA A 136LEU A 156 | 1.34A | 19.51 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1YAJ_D_BEZD2385_0 (CES1 PROTEIN) | Benzoic Acid | 4 / 5 | LEU A 147SER A 77LEU C 5LEU C 7 | 1.39A | 18.11 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ICT_D_T44D129_2 (TRANSTHYRETIN) | Levothyroxine | 4 / 7 | LEU A 147LEU C 10SER A 77THR A 73 | 1.31A | 19.29 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2NV4_A_ACTA148_0 (UPF0066 PROTEINAF_0241) | Acetic acid | 3 / 3 | VAL A 249GLU A 254GLU A 253 | 1.61A | 20.77 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2R2V_C_ACTC36_0 (GCN4 LEUCINE ZIPPER) | Acetic acid | 5 / 10 | TYR A 118ALA A 139ALA A 140SER A 143TYR A 84 | 1.69A | 11.30 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4L1W_A_STRA402_1 (ALDO-KETO REDUCTASEFAMILY 1 MEMBER C2) | Progesterone | 4 / 7 | TYR A 99VAL A 34ILE A 52LEU A 168 | 1.43A | 20.83 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4L39_A_SALA602_1 (4-SUBSTITUTEDBENZOATES-GLUTAMATELIGASE GH3.12) | Salicylic acid | 4 / 6 | LEU A 81TYR A 123ILE A 142GLY A 83 | 1.36A | 19.29 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5GPG_A_RAPA301_1 (PEPTIDYL-PROLYLCIS-TRANS ISOMERASEFKBP3) | Sirolimus | 5 / 11 | LEU A 172VAL A 28TRP A 51TYR A 209ALA A 182 | 1.67A | 21.70 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2CML_A_ZMRA1477_1 (NEURAMINIDASE) | Zanamivir | 5 / 12 | ARG A 97ARG A 62GLU C 2GLU A 163TYR A 99 | 1.71A | 19.14 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ZBR_A_NPSA603_1 (SERUM ALBUMIN) | Naproxen | 6 / 10 | ARG A 234LEU A 206LEU A 215ALA A 205LEU A 230ALA A 245 | 1.68A | 20.68 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4XP3_A_DX4A401_0 (MITOGEN-ACTIVATEDPROTEIN KINASE 1) | Tioguanine | 4 / 6 | ALA A 150GLN A 155LEU A 147LEU C 5 | 1.64A | 22.91 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4YVP_B_GBMB402_1 (ALDO-KETO REDUCTASEFAMILY 1 MEMBER C1) | Glyburide | 5 / 12 | TYR A 74LEU C 10ILE A 124HIS A 9LEU A 156 | 1.42A | 21.07 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ELZ_A_CHDA151_0 (ILEAL BILEACID-BINDING PROTEIN) | Cholic Acid | 4 / 7 | ILE A 52GLY A 175TYR A 209LEU A 168 | 1.25A | 20.00 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4X1I_B_LOCB502_1 (TUBULIN ALPHA CHAINTUBULIN BETA CHAIN) | Colchicine | 3 / 3 | SER A 132ALA A 153VAL A 152 | 0.86A | 21.15 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6EF6_A_ACTA405_0 (AMINOGLYCOSIDEPHOSPHOTRANSFERASE) | Acetic acid | 4 / 6 | THR A 138GLN A 144ARG A 145ILE A 142 | 1.44A | 22.13 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5BS8_G_MFXG101_1 (DNA GYRASE SUBUNIT ADNA GYRASE SUBUNIT BDNA SUBSTRATE 24-MERTTACGTGCATAGTCATTCATGACC) | Moxifloxacin | 4 / 7 | ALA A 11ASP B 53ARG A 35GLU A 46 | 1.31A | 20.5822.57 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1VQ1_B_SAMB301_0 (N5-GLUTAMINEMETHYLTRANSFERASE,HEMK) | S-Adenosylmethionine | 5 / 12 | GLY A 107GLY A 104SER A 2VAL A 165GLU A 166 | 1.19A | 21.90 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1MXG_A_ACRA444_1 (ALPHA AMYLASE) | Acarbose | 4 / 7 | TYR A 74ASN A 114TYR A 159GLY A 112 | 1.53A | 22.17 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2W8Y_A_486A1000_1 (PROGESTERONERECEPTOR) | Mifepristone | 5 / 12 | LEU A 266GLY A 207GLN A 242ARG A 234LEU A 272 | 1.42A | 22.07 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2LBD_A_REAA500_1 (RETINOIC ACIDRECEPTOR GAMMA) | Tretinoin | 5 / 12 | ARG A 14ARG A 75PHE A 22SER A 38GLY A 120 | 1.62A | 20.56 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3TGV_B_BEZB160_0 (HEME-BINDING PROTEINHUTZ) | Benzoic Acid | 4 / 4 | LEU A 109GLY A 112LEU A 130GLU A 128 | 1.43A | 20.30 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1TW4_A_CHDA130_0 (FATTY ACID-BINDINGPROTEIN) | Cholic Acid | 5 / 12 | LEU A 160LEU A 156MET A 98LEU A 130ARG A 111 | 1.47A | 18.61 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2F0Z_A_ZMRA381_1 (SIALIDASE 2) | Zanamivir | 5 / 12 | ARG A 97GLU A 63TYR A 171TYR A 59TYR A 159 | 1.61A | 22.50 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1GTN_E_TRPE81_0 (TRP RNA-BINDINGATTENUATION PROTEIN) | L-Tryptophan | 4 / 6 | SER B 33GLY A 120THR A 94ILE B 1 | 1.40A | 20.20 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1FML_B_RTLB501_0 (RETINOL DEHYDRATASE) | Vitamin A | 5 / 12 | LEU C 10LEU C 8HIS B 31TYR A 123ILE A 124 | 1.51A | 1.99 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4CP3_B_RBTB1129_1 (B-CELL LYMPHOMA 6PROTEIN) | Rifabutin | 4 / 7 | ARG A 169LEU A 168GLY A 1SER A 2 | 1.32A | 18.15 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5YN6_A_SAMA401_0 (NSP16 PROTEIN) | S-Adenosylmethionine | 5 / 12 | GLY A 237GLY A 207LEU A 32ASP B 53ASP A 238 | 1.72A | 20.24 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5HI2_A_BAXA801_1 (SERINE/THREONINE-PROTEIN KINASE B-RAF) | Sorafenib | 5 / 12 | GLU C 2LEU A 160TRP A 133LEU A 168GLY A 100 | 1.67A | 2.89 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6CE2_B_SVRB202_1 () | Suramin | 4 / 8 | LEU A 272LEU A 270LEU A 206GLY A 207 | 1.10A | 15.91 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4Z3O_F_MFXF101_1 (DNA TOPOISOMERASE 4SUBUNITB,PARE30-PARC55FUSED TOPO IV FROMS. PNEUMONIAEE-SITE DNA) | Moxifloxacin | 4 / 5 | ARG A 82GLY A 91GLU A 89SER B 33 | 1.34A | 16.30 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3V3N_A_MIYA2001_1 (TETX2 PROTEIN) | Minocycline | 5 / 11 | GLN A 72ARG A 14MET A 12PRO A 43PHE A 36 | 1.45A | 21.71 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5SYF_B_TA1B502_1 (TUBULIN BETA CHAIN) | Paclitaxel | 5 / 12 | ASP B 53ASP A 238ALA A 49PRO A 47ARG A 35 | 1.60A | 12.68 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ZMA_A_ACAA501_1 (6-AMINOHEXANOATE-DIMER HYDROLASE) | Aminocaproic Acid | 4 / 8 | TYR A 123TYR A 84TYR A 118HIS A 93 | 1.08A | 24.42 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1GFZ_A_CFFA940_1 (GLYCOGENPHOSPHORYLASE) | Caffeine | 5 / 6 | ASN B 24PHE B 22HIS B 13ALA A 236GLY A 237 | 1.77A | 7.87 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ONN_A_ACTA271_0 (PROTEIN SSM1) | Acetic acid | 4 / 5 | GLY A 18GLU A 19GLY A 16PRO A 20 | 1.68A | 20.00 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3UPR_C_1KXC277_2 (HLA CLASS IHISTOCOMPATIBILITYANTIGEN, B-57 ALPHACHAINPEP-V) | Abacavir | 3 / 3 | ILE A 66LEU C 5VAL A 152 | 0.87A | 3.01 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5E3I_B_HISB502_0 (HISTIDINE--TRNALIGASE) | L-Histidine | 5 / 11 | GLU A 163GLU A 63TYR A 99TYR A 7ALA C 4 | 1.52A | 21.35 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6HIS_A_TKTA508_0 (5-HYDROXYTRYPTAMINERECEPTOR 3A) | Tropisetron | 4 / 8 | ASP B 53ILE A 23ARG A 35TYR A 7 | 1.54A | 14.10 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ID5_A_T27A601_1 (REVERSETRANSCRIPTASE/RIBONUCLEASE H) | Rilpivirine | 5 / 12 | PRO A 235VAL B 82VAL B 9TYR B 66PRO B 5 | 1.48A | 19.18 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ZIA_B_CL9B401_2 (DEOXYCYTIDINE KINASE) | Cladribine | 4 / 4 | ARG A 131ASP A 129LEU A 160ARG A 151 | 1.46A | 20.78 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2O4N_A_TPVA300_1 (PROTEASE) | Tipranavir | 5 / 12 | LEU A 270ALA A 205ILE A 213GLY A 207LEU A 266 | 1.23A | 13.14 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2F9W_A_PAUA6002_0 (PANTOTHENATE KINASE) | Pantothenic acid | 4 / 8 | THR C 3TYR A 99GLY C 1ILE A 66 | 1.37A | 4.37 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3SJ0_X_DXCX75_0 (CYTOCHROME C7) | Deoxycholic Acid | 4 / 7 | ILE A 23PHE B 62LYS A 121GLY A 120 | 1.75A | 12.02 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2QHF_A_ACTA503_0 (CHORISMATE SYNTHASE) | Acetic acid | 4 / 5 | GLN A 72THR A 71ARG A 75ARG A 79 | 1.52A | 21.12 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4NDN_C_SAMC405_0 (S-ADENOSYLMETHIONINESYNTHASE ISOFORMTYPE-2) | S-Adenosylmethionine | 4 / 7 | LYS B 58SER B 55PHE A 8ASP A 30 | 1.69A | 12.56 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4O0U_A_ADNA501_1 (AURORA KINASE A) | Adenosine | 4 / 6 | VAL A 152ALA A 150THR A 73LEU C 9 | 1.33A | 22.68 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5IGI_A_ZITA402_2 (MACROLIDE2'-PHOSPHOTRANSFERASE) | Azithromycin | 4 / 6 | PRO A 185HIS A 188ALA A 246TYR B 10 | 1.35A | 20.62 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4IQQ_A_D16A402_1 (THYMIDYLATE SYNTHASE) | Raltitrexed | 4 / 7 | TYR A 171ILE A 52LEU A 179GLY A 175 | 1.23A | 21.35 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2XCT_G_CPFG1020_1 (DNA GYRASE SUBUNITB, DNA GYRASESUBUNIT A) | Ciprofloxacin | 3 / 3 | ARG A 14GLY A 16SER A 88 | 1.06A | 18.56 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5I9Y_A_1N1A1001_1 (EPHRIN TYPE-ARECEPTOR 2) | Dasatinib | 5 / 12 | ILE A 213ALA A 205THR A 187GLY A 265LEU A 266 | 1.32A | 21.75 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4K0B_B_SAMB504_1 (S-ADENOSYLMETHIONINESYNTHASE) | S-Adenosylmethionine | 4 / 8 | PRO B 32ALA A 11SER B 33ASP B 34 | 1.51A | 15.54 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2VQY_A_PARA1201_1 (AAC(6')-IB) | Paromomycin | 5 / 12 | TYR A 27GLU C 2SER A 67ASP B 53ASP A 37 | 1.69A | 21.79 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4QC6_B_KANB201_1 (BIFUNCTIONAL AAC/APH) | Kanamycin | 5 / 12 | TYR A 209HIS A 3ASP A 30HIS A 263GLU A 264 | 1.58A | 18.90 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2HC4_A_VDXA525_2 (VITAMIN D RECEPTOR) | Calcitriol | 5 / 7 | LEU C 9LEU C 7ILE A 66ARG A 62TYR A 74 | 1.48A | 4.29 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4FEU_D_KAND301_1 (AMINOGLYCOSIDE3'-PHOSPHOTRANSFERASE APHA1-IAB) | Kanamycin | 4 / 8 | ASP A 37ASP A 39GLU C 2ASP B 53 | 1.39A | 23.84 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5L2T_A_6ZZA900_1 (CYCLIN-DEPENDENTKINASE 6) | Ribociclib | 5 / 12 | ALA A 49VAL A 28PHE A 33ASP A 177LEU A 179 | 1.24A | 21.30 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4IV0_A_SAMA302_0 (PHOSPHOETHANOLAMINEN-METHYLTRANSFERASE,PUTATIVE) | S-Adenosylmethionine | 5 / 12 | VAL B 37ILE A 23ILE B 35SER B 52HIS B 51 | 1.39A | 15.19 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4R7L_A_SHHA709_1 (LEUKOTRIENE A-4HYDROLASE) | Vorinostat | 5 / 12 | ALA A 117TYR A 74GLU C 2TRP B 60PHE B 56 | 1.62A | 18.25 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3NDV_A_AICA375_1 (BETA-PEPTIDYLAMINOPEPTIDASE) | Ampicillin | 5 / 11 | GLY A 112LEU A 126ASN A 127LEU A 156LEU A 160 | 1.44A | 20.42 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4XO7_B_ASDB402_1 (ALDO-KETO REDUCTASEFAMILY 1 MEMBER C2) | 4-Androstenedione | 4 / 7 | TYR A 7VAL A 34TRP A 167LEU A 168 | 1.46A | 20.66 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1HZ4_A_BEZA784_0 (MALT REGULATORYPROTEIN) | Benzoic Acid | 4 / 6 | HIS A 93LEU A 95LEU A 78PRO A 20 | 1.65A | 19.49 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5BTI_E_LFXE101_1 (DNA GYRASE SUBUNIT ADNA GYRASE SUBUNIT BDNA SUBSTRATE 24-MERGGTCATGAATGACTATGCACGTAA) | Levofloxacin | 4 / 5 | SER B 33ARG A 82GLY A 91GLU A 89 | 1.58A | 9.5517.39 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6EXI_C_ADNC502_0 (ADENOSYLHOMOCYSTEINASE) | Adenosine | 5 / 12 | LEU A 78GLN A 96THR A 94ASN A 70HIS A 9 | 1.73A | 18.67 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ZUC_A_T98A201_1 (PROGESTERONERECEPTOR) | Tanaproget | 5 / 10 | ASN A 70LEU A 126TYR A 7THR A 24PHE A 22 | 1.76A | 21.81 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1F9G_A_ASCA950_0 (HYALURONATE LYASE) | Vitamin C | 4 / 7 | ARG A 62TYR A 74ARG A 97ASN A 114 | 1.69A | 16.07 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1A4L_D_DCFD1853_2 (ADENOSINE DEAMINASE) | Pentostatin | 4 / 4 | HIS A 9LEU A 160LEU A 126LEU A 147 | 1.77A | 21.66 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2WEY_A_EV1A1771_1 (CAMP ANDCAMP-INHIBITED CGMP3', 5'-CYCLICPHOSPHODIESTERASE) | Papaverine | 5 / 12 | LEU A 179VAL A 28ILE A 52TYR A 59GLU A 53 | 1.51A | 21.47 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1KI3_A_PE2A1_1 (THYMIDINE KINASE) | Penciclovir | 5 / 12 | GLU A 163ILE A 66TYR A 99ARG A 62GLU A 63 | 1.73A | 24.78 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3G89_A_SAMA303_0 (RIBOSOMAL RNA SMALLSUBUNITMETHYLTRANSFERASE G) | S-Adenosylmethionine | 5 / 12 | GLY A 207ALA A 205THR A 187ARG A 181ALA A 182 | 1.55A | 23.08 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2VAX_D_CSCD1383_1 (ACETYL-COA--DEACETYLCEPHALOSPORIN CACETYLTRANSFERASE) | Cephalosporin C | 5 / 12 | LEU A 95THR A 94TYR B 63HIS A 9PHE A 22 | 1.73A | 20.53 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2MJI_A_KTRA201_1 (FATTY ACID-BINDINGPROTEIN, INTESTINAL) | Ketorolac | 5 / 12 | ILE B 35TYR B 66LEU B 39LEU B 23TYR B 10 | 1.50A | 23.53 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1HTT_D_HISD450_0 (HISTIDYL-TRNASYNTHETASE) | L-Histidine | 5 / 12 | GLU A 163LEU A 156TYR A 99GLY C 1ALA C 4 | 1.56A | 22.40 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1DVT_A_FLPA125_1 (TRANSTHYRETIN) | Flurbiprofen | 5 / 8 | LEU C 5ALA C 6LEU C 8LEU A 78SER A 77 | 1.54A | 6.25 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4XI3_A_29SA601_1 (ESTROGEN RECEPTOR) | Bazedoxifene | 5 / 12 | THR A 240ALA A 236ASP A 238HIS A 263PRO B 14 | 1.64A | 20.77 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6G6R_A_SAMA406_0 (S-ADENOSYLMETHIONINESYNTHASE ISOFORMTYPE-2) | S-Adenosylmethionine | 4 / 7 | LYS B 58SER B 55PHE A 8ASP A 30 | 1.74A | 12.56 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4FU8_A_ACTA304_0 (UROKINASE-TYPEPLASMINOGENACTIVATOR) | Acetic acid | 3 / 3 | ARG A 97HIS A 9TYR A 99 | 1.56A | 21.95 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3K37_A_BCZA468_1 (NEURAMINIDASE) | Peramivir | 3 / 3 | ASP A 37ARG A 35ARG A 14 | 1.37A | 21.57 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3MBH_B_PXLB400_1 (PUTATIVEPHOSPHOMETHYLPYRIMIDINE KINASE) | Pyridoxal | 5 / 12 | LEU A 95HIS A 93GLN A 87TYR A 123TYR A 85 | 1.55A | 22.33 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3BRF_A_SORA1_0 (LIN-12 AND GLP-1PHENOTYPE PROTEIN 1,ISOFORM A) | Sorbitol | 3 / 3 | GLY A 100ASP A 102SER A 4 | 1.49A | 19.58 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3B7E_A_ZMRA1001_1 (NEURAMINIDASE) | Zanamivir | 5 / 12 | ARG A 97ARG A 62GLU C 2GLU A 163TYR A 99 | 1.74A | 21.16 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2IGT_A_SAMA1001_1 (SAM DEPENDENTMETHYLTRANSFERASE) | S-Adenosylmethionine | 3 / 3 | ASP A 223ASP A 227ASP A 220 | 1.16A | 24.57 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3RXH_A_HSMA7_1 (CATIONIC TRYPSIN) | Histamine | 4 / 5 | ASP B 59SER B 61SER B 55GLY B 29 | 1.57A | 14.16 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2OGY_A_C2FA3000_0 (5-METHYLTETRAHYDROFOLATE CORRINOID/IRONSULFUR PROTEINMETHYLTRANSFERASE) | Levomefolic acid | 5 / 12 | GLU A 63PHE A 33ASN A 70LEU C 8ILE A 66 | 1.49A | 21.64 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1KF6_B_ACTB704_0 (FUMARATE REDUCTASEFLAVOPROTEINFUMARATE REDUCTASEIRON-SULFUR PROTEIN) | Acetic acid | 3 / 3 | ARG A 6GLY A 112ASP A 102 | 0.98A | 17.6522.74 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5NWW_A_ACAA18_2 (SCRFP-TAG,GP41) | Aminocaproic Acid | 3 / 3 | LYS B 58TRP B 60SER B 57 | 1.13A | 17.86 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1TZ8_B_DESB128_1 (TRANSTHYRETIN) | Diethylstilbestrol | 5 / 11 | LYS A 146LEU C 9LEU A 81LEU A 95THR A 73 | 1.44A | 19.29 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3OWX_A_XRAA233_1 (RIBOSYLDIHYDRONICOTINAMIDE DEHYDROGENASE[QUINONE]) | Prazosin | 5 / 9 | TRP A 60GLY C 1MET A 5TYR A 7VAL A 28 | 1.61A | 21.77 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5GS4_A_ESTA603_1 (ESTROGEN RECEPTOR) | Estradiol | 5 / 12 | THR A 187LEU A 206ALA A 205GLY A 265LEU A 266 | 1.15A | 20.64 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ADS_A_IMNA2_2 (PEROXISOMEPROLIFERATOR-ACTIVATED RECEPTOR GAMMA) | Indomethacin | 4 / 6 | ILE A 23ILE A 52LEU B 54PHE B 56 | 1.43A | 21.88 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3OXC_A_ROCA401_2 (PROTEASE) | Saquinavir | 3 / 3 | ARG A 48LEU A 32THR A 24 | 1.29A | 14.23 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4E3A_B_ADNB500_1 (SUGAR KINASE PROTEIN) | Adenosine | 5 / 12 | ASN A 114GLY A 100THR C 3LEU A 156GLY A 26 | 1.38A | 22.28 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4G1B_B_ECNB403_1 (FLAVOHEMOGLOBIN) | Econazole | 5 / 11 | GLN A 115ALA A 125LEU A 126LEU A 160TYR A 159 | 1.44A | 22.06 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5FHZ_C_REAC602_1 (ALDEHYDEDEHYDROGENASE FAMILY1 MEMBER A3) | Tretinoin | 5 / 10 | ILE A 124LEU A 147ASN A 127LEU A 126LEU A 156 | 1.56A | 19.59 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ZW9_B_SAMB801_0 (LEUCINE CARBOXYLMETHYLTRANSFERASE 2) | S-Adenosylmethionine | 5 / 12 | GLY A 26LEU A 32ASP A 29GLU C 2TYR A 171 | 1.60A | 17.51 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4G5J_A_0WMA1103_1 (EPIDERMAL GROWTHFACTOR RECEPTOR) | Afatinib | 4 / 5 | ASN A 114ARG A 6MET A 98HIS A 9 | 1.67A | 22.35 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5BTF_F_GFNF101_1 (DNA GYRASE SUBUNIT ADNA GYRASE SUBUNIT BDNA SUBSTRATE 24-MERTTACGTGCATAGTCATTCATGACC) | Gatifloxacin | 4 / 7 | SER B 33ARG A 82GLY A 91GLU A 89 | 1.17A | 9.5517.39 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4KOW_A_CFXA204_1 (UNCHARACTERIZEDPROTEIN) | Cefoxitin | 5 / 12 | TYR A 159GLY A 100ASN A 114MET A 98ARG A 62 | 1.76A | 21.58 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1K5Q_B_PACB559_0 (PENICILLIN G ACYLASEALPHA SUBUNITPENICILLIN G ACYLASEBETA SUBUNIT) | Phenylacetic acid | 4 / 7 | SER A 143ALA A 139TYR A 85SER A 77 | 1.50A | 22.3420.23 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4IKK_B_SUZB201_1 (TRANSTHYRETIN) | Sulindac | 4 / 7 | LEU A 147LEU C 10SER A 77THR A 73 | 1.29A | 19.29 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5AXA_A_ADNA502_2 (ADENOSYLHOMOCYSTEINASE) | Adenosine | 4 / 5 | GLU A 232THR A 228HIS A 260LEU A 215 | 1.75A | 20.86 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4IK7_B_IMNB201_1 (TRANSTHYRETIN) | Indomethacin | 4 / 8 | LEU A 147LEU C 10SER A 77THR A 73 | 1.24A | 19.29 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5H2U_C_1N1C501_1 (PROTEIN-TYROSINEKINASE 6) | Dasatinib | 6 / 12 | ALA A 205LEU A 270THR A 187GLY A 265GLU A 264LEU A 266 | 1.54A | 23.96 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1HMY_A_SAMA328_0 (HAEIIIMETHYLTRANSFERASE) | S-Adenosylmethionine | 4 / 8 | PHE B 30ASP B 34ILE B 35LEU B 54 | 1.28A | 16.90 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1GMK_B_DVAB6_0 (GRAMICIDIN A) | L-Valine | 4 / 4 | VAL A 248TRP A 217ALA A 245VAL A 247 | 1.76A | 4.40 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4FGJ_A_1PQA304_0 (RIBOSYLDIHYDRONICOTINAMIDE DEHYDROGENASE[QUINONE]) | Primaquine | 4 / 8 | PHE B 56ILE A 23GLY A 26GLU C 2 | 1.18A | 17.30 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6DJZ_C_GMJC301_0 (SIGMA NON-OPIOIDINTRACELLULARRECEPTOR 1) | Haloperidol | 6 / 12 | ALA A 158PHE A 33VAL A 28VAL A 34LEU C 5ALA C 4 | 1.61A | 24.21 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4MA7_A_P2ZA301_1 (MAJOR PRION PROTEIN) | Promazine | 5 / 8 | LEU A 95TYR A 123TYR A 116ILE A 124VAL A 152 | 1.69A | 17.95 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1KT6_A_RTLA184_0 (PLASMARETINOL-BINDINGPROTEIN) | Vitamin A | 5 / 11 | LEU C 5LEU A 147ALA A 136VAL A 152LEU A 126 | 1.60A | 6.17 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4IK6_B_LURB201_1 (TRANSTHYRETIN) | Lumiracoxib | 4 / 8 | LEU A 160GLU A 163ALA A 158LEU A 130 | 1.28A | 19.29 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1GTI_F_CCSF47_0 (GLUTATHIONES-TRANSFERASE) | Carbocisteine | 4 / 5 | THR B 71LEU B 23LYS B 41TYR B 78 | 1.58A | 15.94 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5UTU_F_ADNF503_2 (ADENOSYLHOMOCYSTEINASE) | Adenosine | 4 / 4 | GLU A 232THR A 233GLU A 212HIS A 3 | 1.19A | 19.84 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3IV6_A_SAMA301_1 (PUTATIVEZN-DEPENDENT ALCOHOLDEHYDROGENASE) | S-Adenosylmethionine | 3 / 3 | SER A 92ASP B 34ASP A 119 | 1.46A | 22.30 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5VUO_B_MTLB805_0 (NITRIC OXIDESYNTHASE, BRAIN) | Mannitol | 4 / 8 | GLN A 96PHE A 8ASN A 114TRP B 60 | 1.53A | 20.70 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3AF0_A_PAUA314_0 (PANTOTHENATE KINASE) | Pantothenic acid | 4 / 8 | VAL A 103LEU A 130GLY A 112TYR A 159 | 1.29A | 22.19 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4PUO_C_NVPC901_1 (HIV-1 REVERSETRANSCRIPTASE, P66SUBUNIT) | Nevirapine | 4 / 8 | LEU A 81TYR A 74LEU C 10TYR A 84 | 1.16A | 19.89 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3E00_A_9CRA7223_1 (RETINOIC ACIDRECEPTOR RXR-ALPHA) | Alitretinoin | 5 / 12 | ALA A 140ALA A 139GLN A 141ALA A 135ILE B 1 | 1.16A | 20.37 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3VW1_B_CVIB301_0 (PUTATIVE REGULATORYPROTEIN) | Gentian Violet | 5 / 12 | LEU C 10THR A 94TYR A 116ALA C 6LEU A 78 | 1.21A | 9.68 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3TBG_D_RTZD2_1 (CYTOCHROME P450 2D6) | Thioridazine | 5 / 9 | PHE A 208LEU A 215THR A 216VAL A 261ILE A 213 | 1.53A | 21.99 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1MCN_P_DHIP1_0 (IMMUNOGLOBULINLAMBDA DIMER MCG(LIGHT CHAIN)PEPTIDEN-ACETYL-D-HIS-L-PRO-NH2) | L-Histidine | 3 / 3 | PHE A 241TYR B 63PRO A 235 | 1.35A | 24.491.03 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1SKX_A_RFPA1_2 (ORPHAN NUCLEARRECEPTOR PXR) | Rifampicin | 4 / 5 | LYS A 121PHE A 22MET A 12LEU B 64 | 1.73A | 23.03 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6A4I_B_TRPB403_0 (TRYPTOPHAN2,3-DIOXYGENASE) | L-Tryptophan | 4 / 7 | ARG A 234TRP B 95PRO B 14PRO B 72 | 1.66A | 21.05 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4OGR_A_ADNA401_1 (CYCLIN-DEPENDENTKINASE 9) | Adenosine | 4 / 8 | ILE B 7GLY B 29VAL B 27LEU B 87 | 1.00A | 14.24 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1TYR_A_9CRA131_1 (TRANSTHYRETIN) | Alitretinoin | 4 / 6 | LEU A 147LEU C 10SER A 77THR A 73 | 1.28A | 19.29 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2QEB_A_HSMA145_1 (D7R4 PROTEIN) | Histamine | 4 / 7 | ARG A 62TYR A 7TYR A 99GLU A 163 | 1.53A | 21.77 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5EEN_A_5OGA804_1 (HDAC6 PROTEIN) | Belinostat | 5 / 12 | PRO A 43SER A 67PHE A 36PHE A 22ASP A 39 | 1.78A | 20.98 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6NCS_A_ACTA303_0 (N-ACETYLNEURAMINICACID (SIALIC ACID)SYNTHETASE) | Acetic acid | 3 / 3 | ILE A 213THR A 214PRO A 185 | 0.76A | 21.61 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4JD6_A_TOYA501_1 (ENHANCEDINTRACELLULARSURVIVAL PROTEIN) | Tobramycin | 5 / 9 | ASP B 53ILE A 23SER A 67TYR A 59GLU A 46 | 1.64A | 10.75 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3VAQ_B_ADNB401_1 (PUTATIVE ADENOSINEKINASE) | Adenosine | 6 / 12 | ASN A 114LEU C 5GLY A 100THR C 3LEU A 156GLY A 26 | 1.56A | 21.11 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2BXE_A_1FLA2002_1 (SERUM ALBUMIN) | Diflunisal | 5 / 10 | ALA A 246ALA A 245ALA A 205LEU A 201VAL A 189 | 1.48A | 19.35 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1D4F_B_ADNB602_2 (S-ADENOSYLHOMOCYSTEINE HYDROLASE) | Adenosine | 4 / 5 | THR A 73THR A 69THR C 3HIS A 9 | 1.53A | 22.82 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1KIA_C_SAMC2293_0 (GLYCINEN-METHYLTRANSFERASE) | S-Adenosylmethionine | 5 / 12 | ILE A 52VAL A 34MET A 5LEU C 5TYR A 59 | 1.35A | 22.99 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2HTQ_A_ZMRA472_1 (NEURAMINIDASE) | Zanamivir | 5 / 12 | GLU A 55ALA C 4GLU A 163TYR A 7TYR A 171 | 1.56A | 21.07 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2NXE_A_SAMA302_1 (RIBOSOMAL PROTEINL11METHYLTRANSFERASE) | S-Adenosylmethionine | 3 / 3 | THR A 64ASP B 53SER B 55 | 0.75A | 22.04 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4LG1_C_SAMC301_0 (PROTEIN-LYSINEMETHYLTRANSFERASEMETTL21D) | S-Adenosylmethionine | 5 / 12 | GLY A 112LEU A 156LEU A 160TRP A 133TYR A 116 | 1.31A | 22.61 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5I9X_A_DB8A1001_1 (EPHRIN TYPE-ARECEPTOR 2) | Bosutinib | 5 / 12 | ILE A 213ALA A 205THR A 187GLY A 265LEU A 266 | 1.38A | 21.75 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6A60_D_9CRD501_0 (RETINOIC ACIDRECEPTOR RXR-ALPHA) | Alitretinoin | 5 / 12 | ALA A 140ALA A 139GLN A 141ALA A 135ILE B 1 | 1.11A | 20.42 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3G1U_C_ADNC438_2 (ADENOSYLHOMOCYSTEINASE) | Adenosine | 4 / 5 | GLN A 224THR A 225THR A 214HIS A 260 | 1.68A | 21.38 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5I73_A_68PA701_1 (SODIUM-DEPENDENTSEROTONINTRANSPORTER) | Citalopram | 6 / 12 | TYR A 7ILE A 52GLY C 1GLY A 26LEU A 32GLY A 56 | 1.77A | 18.80 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5C0O_G_SAMG301_1 (TRNA(ADENINE(58)-N(1))-METHYLTRANSFERASETRMI) | S-Adenosylmethionine | 3 / 3 | GLU A 264HIS A 263ASP A 30 | 1.56A | 23.39 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4AN2_A_EUIA1382_2 (DUAL SPECIFICITYMITOGEN-ACTIVATEDPROTEIN KINASEKINASE 1) | Cobimetinib | 4 / 4 | ASN A 70SER A 143LEU C 10THR A 69 | 1.33A | 20.95 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ERG_B_SAMB401_1 (TRNA(ADENINE(58)-N(1))-METHYLTRANSFERASECATALYTIC SUBUNITTRM61) | S-Adenosylmethionine | 4 / 7 | GLY A 107GLY A 104SER A 2ASP A 106 | 1.20A | 20.92 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1P6K_A_MTLA870_0 (NITRIC-OXIDESYNTHASE, BRAIN) | Mannitol | 4 / 8 | GLN A 96PHE A 8ASN A 114TRP B 60 | 1.55A | 20.05 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4G24_A_ACAA1004_1 (PENTATRICOPEPTIDEREPEAT-CONTAININGPROTEIN AT2G32230,MITOCHONDRIAL) | Aminocaproic Acid | 4 / 6 | ALA A 153LEU A 156ASP A 129GLU A 128 | 1.05A | 18.02 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4TWD_F_377F401_1 (CYS-LOOPLIGAND-GATED IONCHANNEL) | Memantine | 4 / 7 | GLU A 55GLU A 63TYR A 7TYR A 171 | 1.28A | 21.65 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1MRG_A_ADNA300_1 (ALPHA-MOMORCHARIN) | Adenosine | 5 / 9 | TYR A 159GLY A 100TYR A 7GLU A 63ARG A 62 | 1.54A | 23.70 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5X1B_C_CHDC304_0 (CYTOCHROME C OXIDASESUBUNIT 3) | Cholic Acid | 3 / 3 | ARG A 21PHE A 8LEU B 54 | 1.45A | 18.21 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1X70_B_715B801_2 (DIPEPTIDYL PEPTIDASEIV) | Sitagliptin | 3 / 3 | PHE A 22TYR A 99TYR A 7 | 1.39A | 17.15 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3CJT_C_SAMC302_0 (RIBOSOMAL PROTEINL11METHYLTRANSFERASE) | S-Adenosylmethionine | 5 / 12 | HIS B 31LEU A 81ILE A 124SER A 143LEU A 95 | 1.27A | 14.57 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4KOY_A_CSCA214_1 (UNCHARACTERIZEDPROTEIN) | Cephalosporin C | 5 / 11 | TYR A 159GLY A 100ASN A 114MET A 98ARG A 62 | 1.79A | 21.58 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3FAL_C_REAC501_1 (RETINOIC ACIDRECEPTOR RXR-ALPHA) | Tretinoin | 5 / 10 | ALA A 140ALA A 139GLN A 141ALA A 135ILE B 1 | 1.17A | 20.56 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5GTR_A_ESTA601_2 (ESTROGEN RECEPTOR) | Estradiol | 4 / 5 | LEU A 272LEU A 215LEU A 266HIS A 260 | 1.62A | 20.64 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1FML_A_RTLA401_0 (RETINOL DEHYDRATASE) | Vitamin A | 5 / 12 | TYR A 84LEU C 10HIS B 31LEU A 78TYR A 74 | 1.66A | 19.23 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5GWX_A_SAMA301_1 (GLYCINE SARCOSINEN-METHYLTRANSFERASE) | S-Adenosylmethionine | 3 / 3 | ARG A 111ASN A 127ASP A 122 | 1.57A | 22.93 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4YHA_F_MZMF302_1 (ALPHA-CARBONICANHYDRASE) | Methazolamide | 5 / 10 | HIS A 192VAL A 189LEU A 201THR A 200ALA A 246 | 1.79A | 19.65 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4X61_A_SAMA701_0 (PROTEIN ARGININEN-METHYLTRANSFERASE5) | S-Adenosylmethionine | 5 / 12 | GLY A 112ASN A 127ARG A 97GLU A 161LEU A 160 | 1.60A | 17.16 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ZI9_A_CL9A401_1 (DEOXYCYTIDINE KINASE) | Cladribine | 5 / 12 | ILE A 66GLU A 163MET A 5TYR A 7ARG A 62 | 1.79A | 20.78 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1W5U_A_DVAA6_0 (GRAMICIDIN D) | L-Valine | 3 / 3 | ALA A 149VAL A 152TRP A 133 | 1.80A | 4.40 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1UNM_E_DVAE2_0 (7-AMINOACTINOMYCIN D) | L-Valine | 3 / 3 | THR B 73PRO B 72THR B 71 | 1.56A | 8.54 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4S0V_A_SUVA2001_1 (HUMAN OREXINRECEPTOR TYPE 2FUSION PROTEIN TO P.ABYSII GLYCOGENSYNTHASE) | Suvorexant | 5 / 12 | VAL A 152TRP A 133ILE A 66ASN A 70TYR A 159 | 1.57A | 16.91 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4MJW_A_ACTA603_0 (CHOLINE OXIDASE) | Acetic acid | 3 / 3 | ARG A 82HIS A 93SER A 88 | 1.43A | 19.28 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4N48_B_SAMB601_1 (CAP-SPECIFIC MRNA(NUCLEOSIDE-2'-O-)-METHYLTRANSFERASE 1) | S-Adenosylmethionine | 4 / 5 | ASN B 17PRO B 72GLY B 18ASP A 238 | 1.47A | 13.62 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5CVT_B_ACTB200_0 (N5-CARBOXYAMINOIMIDAZOLE RIBONUCLEOTIDEMUTASE) | Acetic acid | 3 / 3 | ASN B 17ALA B 15ARG B 97 | 1.75A | 17.02 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1TW4_B_CHDB1130_0 (FATTY ACID-BINDINGPROTEIN) | Cholic Acid | 5 / 12 | TYR A 85LEU A 81LEU A 78LEU C 10HIS B 31 | 1.44A | 18.61 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3JWQ_A_VIAA901_1 (CGMP-SPECIFIC3',5'-CYCLICPHOSPHODIESTERASECATALYTIC DOMAIN,CONE CGMP-SPECIFIC3',5'-CYCLICPHOSPHODIESTERASESUBUNIT ALPHACHIMERA) | Sildenafil | 5 / 9 | TYR B 66LEU B 54VAL B 37LEU B 87PHE B 30 | 1.71A | 15.30 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5CFS_A_TOYA203_1 (AAD(2''),GENTAMICIN2''-NUCLEOTIDYLTRANSFERASE,GENTAMICINRESISTANCE PROTEIN) | Tobramycin | 4 / 8 | ASP A 39ASP A 37GLU A 46ASP B 53 | 1.66A | 19.93 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4Z4D_A_IPHA904_0 (PROTEIN ARGONAUTE-2) | Phenol | 4 / 5 | PHE A 33PRO A 47VAL A 34ALA A 49 | 1.54A | 15.37 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1TUV_A_VK3A4558_1 (PROTEIN YGIN) | Menadione | 4 / 7 | HIS B 51LEU B 64MET A 12ILE A 23 | 1.25A | 20.00 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5WEA_A_IPHA901_0 (PROTEIN ARGONAUTE-2) | Phenol | 4 / 5 | LEU A 168LYS A 1LEU A 172GLU A 180 | 1.48A | 15.83 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5BTC_G_CPFG101_1 (DNA GYRASE SUBUNIT ADNA GYRASE SUBUNIT BDNA SUBSTRATE 24-MERTTACGTGCATAGTCATTCATGACC) | Ciprofloxacin | 4 / 6 | SER B 33ARG A 82GLY A 91GLU A 89 | 1.15A | 9.5517.39 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6DK1_B_GM4B301_0 (SIGMA NON-OPIOIDINTRACELLULARRECEPTOR 1) | Pentazocine | 5 / 11 | ALA A 125TYR A 74LEU A 95TRP B 60LEU A 147 | 1.68A | 24.21 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3OCT_A_1N1A663_1 (TYROSINE-PROTEINKINASE BTK) | Dasatinib | 5 / 12 | LEU A 81ALA A 139THR A 138TYR A 84GLY A 83 | 1.51A | 20.75 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5B8I_C_FK5C201_1 (SERINE/THREONINE-PROTEIN PHOSPHATASEPEPTIDYL-PROLYLCIS-TRANS ISOMERASE) | Tacrolimus | 4 / 6 | LEU A 206SER B 11PHE B 22GLU B 69 | 1.45A | 23.21 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3S3M_A_DLUA398_1 (PFV INTEGRASE) | Dolutegravir | 4 / 8 | GLY A 26PRO A 47GLU A 46ARG A 239 | 1.35A | 19.80 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2W8Y_B_NDRB1000_0 (PROGESTERONERECEPTOR) | Norethisterone | 5 / 12 | LEU C 8ASN A 70GLN A 72LEU C 10TYR A 116 | 1.80A | 5.84 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4YIA_B_IMNB401_2 (THYROXINE-BINDINGGLOBULIN) | Indomethacin | 3 / 3 | LEU A 78ARG A 79ARG A 82 | 1.18A | 9.51 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4TWD_A_377A401_1 (CYS-LOOPLIGAND-GATED IONCHANNEL) | Memantine | 4 / 5 | GLU A 55GLU A 63TYR A 7TYR A 171 | 1.34A | 21.65 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1GTI_C_CCSC47_0 (GLUTATHIONES-TRANSFERASE) | Carbocisteine | 4 / 6 | LEU A 160GLY A 162LYS C 1TYR A 159 | 1.11A | 21.05 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5EF8_B_LBHB2004_1 (HDAC6 PROTEIN) | Panobinostat | 5 / 12 | PRO A 43SER A 67PHE A 36PHE A 22ASP A 39 | 1.70A | 20.98 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ZV2_B_LEVB801_2 (FIBROBLAST GROWTHFACTOR RECEPTOR 1) | Lenvatinib | 3 / 3 | TYR A 116LEU A 126ASP A 129 | 1.47A | 21.95 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5XV7_A_EMHA705_2 (SERINE-ARGININE (SR)PROTEIN KINASE 1) | Alectinib | 4 / 4 | VAL A 165LEU A 168LEU A 172ASP A 29 | 1.26A | 22.75 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1M4G_B_RIOB501_0 (AMINOGLYCOSIDE2'-N-ACETYLTRANSFERASE) | Ribostamycin | 5 / 9 | ASP B 53GLY A 26SER A 67THR A 71ASP A 37 | 1.63A | 16.48 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1MX1_D_THAD4_1 (LIVERCARBOXYLESTERASE I) | Tacrine | 5 / 12 | GLY A 175VAL A 28LEU A 179LEU A 172ILE A 52 | 1.35A | 17.55 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4E1G_B_LNLB701_1 (PROSTAGLANDIN G/HSYNTHASE 2) | Alpha-Linolenic Acid | 5 / 12 | ARG A 239TYR A 27TYR B 10GLY A 237GLY A 207 | 1.13A | 17.80 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3BBT_B_FMMB91_1 (RECEPTORTYROSINE-PROTEINKINASE ERBB-4) | Lapatinib | 6 / 12 | ALA A 11LEU B 54THR A 10LEU A 95ASP B 34PHE B 30 | 1.76A | 23.58 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6BM5_A_SAMA1301_0 (METHIONINE SYNTHASE) | S-Adenosylmethionine | 5 / 11 | ARG A 62GLU C 2ARG A 97ALA A 11TYR A 74 | 1.77A | 24.07 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1UWJ_B_BAXB1723_1 (B-RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE) | Sorafenib | 5 / 12 | GLU C 2LEU A 160TRP A 133LEU A 168GLY A 100 | 1.57A | 3.80 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3B9L_A_AZZA1010_1 (SERUM ALBUMIN) | Zidovudine | 5 / 8 | LEU A 206HIS B 13PHE B 22TYR B 10GLY A 237 | 1.66A | 19.35 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2F78_A_BEZA1001_0 (HTH-TYPETRANSCRIPTIONALREGULATOR BENM) | Benzoic Acid | 5 / 9 | LEU C 8LEU C 9LEU A 95ARG A 97TYR A 116 | 1.44A | 4.79 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2HA4_A_ACHA546_0 (ACETYLCHOLINESTERASE) | Acetylcholine | 4 / 8 | TYR A 59GLU A 166TYR A 159GLY A 162 | 1.41A | 19.85 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1JG4_A_SAMA500_0 (PROTEIN-L-ISOASPARTATEO-METHYLTRANSFERASE) | S-Adenosylmethionine | 5 / 12 | THR A 200VAL A 248THR A 228ALA A 245LEU A 215 | 1.44A | 21.32 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6EXI_A_ADNA502_1 (ADENOSYLHOMOCYSTEINASE) | Adenosine | 3 / 3 | LEU C 8ASN A 127LEU A 160 | 0.81A | 4.52 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1QVT_A_PRLA311_0 (TRANSCRIPTIONALREGULATOR QACR) | Proflavine | 4 / 8 | LEU A 147GLU A 148ILE A 124TYR A 116 | 1.38A | 17.92 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3VAS_A_ADNA401_1 (PUTATIVE ADENOSINEKINASE) | Adenosine | 6 / 12 | ASN A 114LEU C 5GLY A 100THR C 3LEU A 156GLY A 26 | 1.53A | 21.16 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4B3Q_A_NVPA999_1 (REVERSETRANSCRIPTASE/RIBONUCLEASE H) | Nevirapine | 4 / 7 | LEU A 81TYR A 74LEU C 10TYR A 84 | 1.38A | 19.78 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2A3A_A_TEPA1435_1 (CHITINASE) | Theophylline | 3 / 3 | TRP A 167GLU A 63TYR A 59 | 0.89A | 20.14 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5D4N_A_ACTA202_0 (NITROGEN REGULATORYPROTEIN P-II) | Acetic acid | 4 / 4 | VAL A 103GLY A 107ARG A 169VAL A 165 | 1.63A | 17.45 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2HA4_B_ACHB603_0 (ACETYLCHOLINESTERASE) | Acetylcholine | 4 / 7 | TYR A 59GLU A 166TYR A 159GLY A 162 | 1.40A | 19.85 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2WUZ_A_TPFA1460_1 (LANOSTEROL14-ALPHA-DEMETHYLASE, PUTATIVE) | Fluconazole | 5 / 10 | ALA A 49THR A 31LEU A 179MET A 5VAL A 28 | 1.35A | 18.33 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1RBP_A_RTLA183_0 (PLASMARETINOL-BINDINGPROTEIN PRECURSOR) | Vitamin A | 6 / 12 | LEU C 5LEU A 147ALA A 140ALA A 136VAL A 152LEU A 126 | 1.49A | 5.59 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1UWH_B_BAXB1723_1 (B-RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE) | Sorafenib | 5 / 12 | GLU C 2LEU A 160TRP A 133LEU A 168GLY A 100 | 1.62A | 3.80 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4IKL_A_SUZA201_1 (TRANSTHYRETIN) | Sulindac | 4 / 7 | LEU A 147LEU C 10SER A 77THR A 73 | 1.26A | 19.29 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2BUE_A_RIOA1201_0 (AAC(6')-IB) | Ribostamycin | 5 / 11 | TYR A 27GLU C 2SER A 67ASP B 53ASP A 37 | 1.69A | 21.79 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5Z3J_A_NCAA302_0 (ABRIN A-CHAIN) | Nicotinamide | 4 / 6 | TYR A 171TYR A 59ILE A 52GLU A 55 | 1.61A | 21.36 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1WU8_C_ADNC502_1 (HYPOTHETICAL PROTEINPH0463) | Adenosine | 4 / 7 | TYR A 7ARG A 97HIS A 9VAL A 25 | 1.78A | 20.98 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5NOO_A_D16A402_1 (THYMIDYLATE SYNTHASE) | Raltitrexed | 4 / 7 | TYR A 171ILE A 52LEU A 179GLY A 175 | 1.27A | 21.35 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1X1A_A_SAMA4264_0 (CRTF-RELATED PROTEIN) | S-Adenosylmethionine | 5 / 12 | ALA C 4GLY C 1ILE A 66LEU A 168ASP A 29 | 1.37A | 2.84 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3V4T_A_ACTA503_0 (UDP-N-ACETYLGLUCOSAMINE1-CARBOXYVINYLTRANSFERASE) | Acetic acid | 3 / 3 | ARG A 62GLU C 2THR C 3 | 1.29A | 22.95 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ETB_2_T442129_1 (TRANSTHYRETIN) | Levothyroxine | 4 / 6 | LEU A 160GLU A 163ALA A 158LEU A 130 | 1.10A | 19.93 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2Z0A_A_GLYA73_0 (NONSTRUCTURALPROTEIN 1) | Glycine | 4 / 5 | ALA A 139GLN A 141ILE A 142ARG A 145 | 1.15A | 14.57 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1Z2B_C_VLBC800_1 (TUBULIN BETA CHAINTUBULIN ALPHA CHAIN) | Vinblastine | 4 / 8 | ASP B 98THR B 73PRO B 72LEU B 23 | 1.37A | 13.24 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5NO9_D_95ZD302_1 (25 KDA PROTEINELICITOR) | Glucosamine | 4 / 7 | GLY A 120HIS B 31HIS A 93ASP A 119 | 1.67A | 20.29 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1NBH_B_ACTB1294_0 (GLYCINEN-METHYLTRANSFERASE) | Acetic acid | 4 / 7 | ASN A 70TYR A 99TYR A 116TYR A 74 | 1.54A | 22.99 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4W5O_A_IPHA906_0 (PROTEIN ARGONAUTE-2) | Phenol | 4 / 5 | PHE A 33PRO A 47VAL A 34ALA A 49 | 1.54A | 15.37 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2JJ8_B_AZZB1211_1 (DEOXYNUCLEOSIDEKINASE) | Zidovudine | 5 / 12 | GLU A 154LEU A 126VAL A 152ARG A 151ALA A 150 | 1.67A | 21.65 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4K39_A_SAMA504_0 (ANAEROBICSULFATASE-MATURATINGENZYME) | S-Adenosylmethionine | 5 / 12 | ASN B 24LEU B 64VAL B 37ILE B 35LEU B 87 | 1.58A | 14.88 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3THR_D_C2FD1200_0 (GLYCINEN-METHYLTRANSFERASE) | Levomefolic acid | 5 / 12 | LEU A 95SER A 38LEU A 78THR A 73THR A 71 | 1.43A | 23.21 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4KOS_A_4KOA201_1 (UNCHARACTERIZEDPROTEIN) | Cefmetazole | 5 / 12 | TYR A 159GLY A 100ASN A 114MET A 98ARG A 62 | 1.78A | 21.58 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5GQB_A_GCSA603_1 (CHITINASE) | Glucosamine | 4 / 8 | GLY A 237TYR A 209ASP A 183ARG A 181 | 1.58A | 18.21 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4XI3_C_29SC601_1 (ESTROGEN RECEPTOR) | Bazedoxifene | 5 / 12 | THR A 187LEU A 206ALA A 205GLY A 265LEU A 266 | 1.09A | 20.77 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1V7Z_A_CRNA401_1 (CREATININEAMIDOHYDROLASE) | Creatine | 4 / 8 | HIS A 3ASP A 29TYR A 171TRP A 51 | 1.58A | 23.45 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5MRA_B_DM2B204_1 (SORCIN) | Epirubicin | 4 / 6 | TYR A 209THR A 31ARG A 239ASP A 238 | 1.62A | 18.77 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4XYZ_A_ACTA103_0 (POLYUBIQUITIN-C) | Acetic acid | 4 / 4 | LEU A 266ILE A 213HIS A 263VAL A 261 | 1.40A | 14.81 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4K37_B_SAMB504_0 (ANAEROBICSULFATASE-MATURATINGENZYME) | S-Adenosylmethionine | 5 / 11 | ASN B 24LEU B 64VAL B 37ILE B 35LEU B 87 | 1.62A | 14.88 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2O5Y_H_STRH249_1 (CHIMERIC ANTIBODYFAB 1E9-DB3) | Progesterone | 4 / 7 | ASN B 17GLY B 18THR B 71SER B 11 | 1.71A | 17.8620.83 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4QB9_C_PARC500_1 (ENHANCEDINTRACELLULARSURVIVAL PROTEIN) | Paromomycin | 5 / 10 | SER B 55THR A 24TYR A 74GLU A 63GLY A 26 | 1.69A | 11.11 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2WX2_A_TPFA1460_1 (LANOSTEROL14-ALPHA-DEMETHYLASE) | Fluconazole | 4 / 7 | TYR A 159ALA C 4ALA C 6THR A 73 | 1.35A | 18.33 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6BPY_A_ACTA408_0 (THIOREDOXINREDUCTASE) | Acetic acid | 3 / 3 | PRO A 15SER A 92SER A 13 | 1.52A | 22.86 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3UQ6_A_ADNA401_1 (ADENOSINE KINASE,PUTATIVE) | Adenosine | 6 / 12 | ASN A 114LEU C 5GLY A 100THR C 3LEU A 156GLY A 26 | 1.54A | 21.11 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4DC3_A_ADNA401_2 (ADENOSINE KINASE) | Adenosine | 4 / 4 | LEU A 266ILE A 213GLY A 265PHE A 208 | 1.31A | 21.11 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3A6J_A_CRNA303_1 (CREATININEAMIDOHYDROLASE) | Creatine | 4 / 8 | HIS A 3ASP A 29TYR A 171TRP A 51 | 1.57A | 23.78 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3N66_B_MTLB870_0 (NITRIC OXIDESYNTHASE) | Mannitol | 4 / 8 | GLN A 96PHE A 8ASN A 114TRP B 60 | 1.50A | 20.70 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3W9T_A_W9TA1002_1 (HEMOLYTIC LECTINCEL-III) | Lactulose | 3 / 3 | ASP A 102GLU A 128GLY A 112 | 1.26A | 19.60 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2EJG_A_ADNA1501_1 (235AA LONGHYPOTHETICALBIOTIN--[ACETYL-COA-CARBOXYLASE] LIGASE) | Adenosine | 4 / 7 | ARG A 170TRP A 51GLU A 53PRO A 47 | 1.67A | 21.86 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ECN_A_LEUA602_0 (JASMONIC ACID-AMIDOSYNTHETASE JAR1) | L-Leucine | 4 / 7 | ALA C 4THR C 3TYR A 159GLU A 63 | 1.49A | None | |||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2DPZ_A_TYLA2001_1 (PHOSPHOLIPASE A2VRV-PL-VIIIA) | Acetaminophen | 4 / 6 | LEU A 179ALA A 49ASP A 183TYR A 209 | 1.59A | 16.36 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5AXD_A_RBVA502_2 (ADENOSYLHOMOCYSTEINASE) | Ribavirin | 3 / 3 | THR A 190HIS A 263LEU A 215 | 1.11A | 20.86 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4DC3_B_2FAB401_1 (ADENOSINE KINASE) | Fludarabine | 5 / 12 | ASN A 114GLY A 100THR C 3LEU A 156GLY A 26 | 1.38A | 21.11 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2X7H_A_PFNA1372_1 (ZINC-BINDING ALCOHOLDEHYDROGENASEDOMAIN-CONTAININGPROTEIN 2) | Fenoprofen | 5 / 11 | TYR A 74LEU C 9LEU C 7HIS A 9THR C 3 | 1.77A | 21.87 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6CI6_A_NBOA607_1 (SERUM ALBUMIN) | Nabumetone | 4 / 7 | ASN A 114ALA A 125GLU A 128LEU A 156 | 1.38A | 20.68 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5JWA_H_ACTH612_0 (NADH DEHYDROGENASE,PUTATIVE) | Acetic acid | 3 / 3 | ARG B 97PRO B 72ASN B 21 | 1.46A | 10.98 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1KIA_B_SAMB1293_0 (GLYCINEN-METHYLTRANSFERASE) | S-Adenosylmethionine | 5 / 12 | ILE A 52GLY A 26VAL A 34GLY C 1TYR A 171 | 1.41A | 22.99 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2PNC_A_CLUA808_1 (COPPER AMINEOXIDASE, LIVERISOZYME) | Clonidine | 4 / 7 | TYR A 74TYR A 116TYR A 99HIS A 9 | 1.76A | 16.14 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ODQ_A_ACTA703_0 (HETERODISULFIDEREDUCTASE, SUBUNIT A) | Acetic acid | 4 / 6 | ARG A 239ALA A 236PRO A 235PHE A 241 | 1.63A | 16.18 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3REQ_A_ADNA801_1 (METHYLMALONYL-COAMUTASE) | Adenosine | 4 / 4 | TYR A 99TYR A 159GLU A 163GLY C 1 | 1.79A | 18.89 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5UC1_B_486B801_2 (GLUCOCORTICOIDRECEPTOR) | Mifepristone | 5 / 12 | LEU A 130LEU A 160GLY A 162VAL A 165ARG A 6 | 1.29A | 21.77 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3BOG_C_DVAC59_0 (6.5 KDA GLYCINE-RICHANTIFREEZE PROTEIN) | L-Valine | 3 / 3 | GLY A 107GLY A 1GLY A 104 | 0.53A | 12.73 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5V4V_A_NCAA402_0 (NADPH DEHYDROGENASE3) | Nicotinamide | 4 / 8 | TYR A 209PHE A 241PRO A 235TYR A 27 | 1.53A | 21.23 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3UVV_B_9CRB501_1 (RETINOIC ACIDRECEPTOR RXR-ALPHA) | Alitretinoin | 5 / 12 | ALA A 140ALA A 139GLN A 141ALA A 135ILE B 1 | 1.13A | 20.42 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ZDY_A_1YNA602_2 (LANOSTEROL 14-ALPHADEMETHYLASE) | Itraconazole | 3 / 3 | ALA A 117TYR A 118PRO B 32 | 1.17A | 17.91 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1NW3_A_SAMA500_1 (HISTONEMETHYLTRANSFERASEDOT1L) | S-Adenosylmethionine | 4 / 4 | THR A 233GLN B 8GLU A 229ASP A 227 | 1.78A | 22.08 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3FAL_A_REAA501_1 (RETINOIC ACIDRECEPTOR RXR-ALPHA) | Tretinoin | 5 / 10 | ALA A 140ALA A 139GLN A 141ALA A 135ILE B 1 | 1.13A | 20.56 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4AFT_D_QMRD301_1 (SOLUBLEACETYLCHOLINERECEPTOR) | Varenicline | 4 / 8 | TYR A 159VAL A 165TYR A 99VAL A 103 | 1.41A | 20.63 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5XOO_A_ADNA506_1 (GLYCOSAMINOGLYCANXYLOSYLKINASE) | Adenosine | 4 / 6 | TYR A 85LEU C 10LYS A 121LEU A 95 | 1.32A | 20.00 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1UNM_E_DVAE8_0 (7-AMINOACTINOMYCIN D) | L-Valine | 3 / 3 | THR B 71THR B 73PRO B 72 | 1.55A | 8.54 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3PFG_A_SAMA264_0 (N-METHYLTRANSFERASE) | S-Adenosylmethionine | 5 / 12 | TYR A 74ALA C 6LEU C 8PHE A 36HIS A 9 | 1.72A | 22.90 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2Q0I_A_BEZA990_0 (QUINOLONE SIGNALRESPONSE PROTEIN) | Benzoic Acid | 4 / 8 | ASP A 238LEU A 206HIS B 13SER B 11 | 1.43A | 21.95 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3AIA_A_SAMA206_0 (UPF0217 PROTEINMJ1640) | S-Adenosylmethionine | 5 / 6 | LEU A 95MET A 12GLY A 120LEU A 78SER A 13 | 1.69A | 21.75 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ZJ0_B_2FAB500_2 (ADENOSYLHOMOCYSTEINASE) | Fludarabine | 4 / 5 | LEU A 78GLN A 96THR A 94THR A 73 | 1.60A | 21.29 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1P62_B_GEOB302_1 (DEOXYCYTIDINE KINASE) | Gemcitabine | 5 / 11 | ILE A 66GLU A 163MET A 5TYR A 7ARG A 62 | 1.76A | 20.82 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5TZO_B_7V7B201_1 (ENDO-1,4-BETA-XYLANASE A) | Fentanyl | 5 / 12 | LEU C 8VAL A 152ALA A 149TYR A 116ALA A 150 | 1.69A | 4.91 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4KOU_A_C04A207_1 (UNCHARACTERIZEDPROTEIN) | Cefixime | 3 / 3 | GLY A 100GLU C 2THR C 3 | 1.20A | 21.58 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3LD6_B_KKKB602_1 (LANOSTEROL 14-ALPHADEMETHYLASE) | Ketoconazole | 5 / 12 | TYR A 7TYR A 99PHE A 22THR A 69ILE A 66 | 1.59A | 20.44 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5KVA_A_SAMA301_1 (CAFFEOYL-COAO-METHYLTRANSFERASE) | S-Adenosylmethionine | 3 / 3 | THR A 94SER B 33ASP A 39 | 1.18A | 22.54 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3H9U_A_ADNA439_1 (ADENOSYLHOMOCYSTEINASE) | Adenosine | 5 / 10 | LEU A 78HIS A 93THR A 94GLN A 96GLY A 120 | 1.67A | 20.13 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3KP6_A_SALA3005_1 (TRANSCRIPTIONALREGULATOR TCAR) | Salicylic acid | 4 / 8 | LEU A 206GLN A 242ALA A 236HIS B 13 | 1.40A | 20.59 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4X1Y_D_LOCD502_1 (TUBULIN ALPHA CHAINTUBULIN BETA CHAIN) | Colchicine | 3 / 3 | SER A 132ALA A 153VAL A 152 | 0.90A | 21.15 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2RLF_A_RIMA199_1 (MATRIX PROTEIN 2) | Rimantadine | 4 / 6 | LEU A 147LEU C 9ILE A 124ARG A 97 | 1.54A | 9.70 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3WQV_A_GCSA501_1 (CHITINASE) | Glucosamine | 5 / 11 | PHE A 33GLU A 63TYR A 159TYR A 99ARG A 97 | 1.73A | 21.87 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5DQF_A_CZEA613_1 (SERUM ALBUMIN) | Cetirizine | 5 / 9 | ARG A 131ALA A 153ASP A 129LEU A 130LEU A 156 | 1.77A | 20.96 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2EJF_B_ADNB2002_1 (235AA LONGHYPOTHETICALBIOTIN--[ACETYL-COA-CARBOXYLASE] LIGASE) | Adenosine | 4 / 6 | ARG A 170TRP A 51GLU A 53PRO A 47 | 1.68A | 21.45 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2AZQ_A_PCFA954_0 (CATECHOL1,2-DIOXYGENASE) | Colfosceril palmitate | 5 / 9 | LEU A 109GLU A 166TYR A 171LEU A 172GLU A 55 | 1.51A | 23.62 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3UCB_A_017A201_2 (PROTEASE) | Darunavir | 5 / 12 | LEU A 201ASP A 223PRO A 250VAL A 249VAL A 247 | 1.25A | 16.79 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6AK3_A_P2EA1201_0 (PROSTAGLANDIN E2RECEPTOR EP3SUBTYPE,SOLUBLECYTOCHROME B562) | Dinoprostone | 5 / 12 | THR A 187VAL A 261THR A 216LEU A 230GLN A 242 | 1.71A | 21.24 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4BJC_A_RPBA2162_1 (TANKYRASE-2) | Rucaparib | 4 / 8 | GLY A 252ALA A 199SER A 251GLU A 198 | 1.43A | 20.33 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2A1M_A_CAMA1422_0 (CYTOCHROME P450-CAM) | Camphor | 4 / 7 | TYR A 59VAL A 34GLY A 26THR A 24 | 1.07A | 21.05 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1HBP_A_RTLA184_0 (RETINOL BINDINGPROTEIN) | Vitamin A | 5 / 11 | LEU C 8ALA A 136ALA A 135VAL A 152LEU A 126 | 1.69A | 6.17 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1SQN_B_NDRB2001_0 (PROGESTERONERECEPTOR) | Norethisterone | 5 / 12 | LEU C 9LEU C 7LEU A 81LEU A 95TYR A 123 | 1.45A | 7.55 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4L7I_B_SAMB501_1 (S-ADENOSYLMETHIONINESYNTHASE) | S-Adenosylmethionine | 4 / 8 | PRO B 32ALA A 11SER B 33ASP B 34 | 1.50A | 15.54 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2Q6O_B_SAMB500_0 (HYPOTHETICAL PROTEIN) | S-Adenosylmethionine | 4 / 6 | ASP A 29VAL A 28PRO A 210TRP A 51 | 1.66A | 23.62 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4G1Q_A_T27A601_1 (REVERSETRANSCRIPTASE/RIBONUCLEASE H) | Rilpivirine | 5 / 12 | PRO A 235VAL B 82VAL B 9TYR B 66PRO B 5 | 1.47A | 19.18 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4Y8W_C_STRC603_1 (CYTOCHROME P45021-HYDROXYLASE) | Progesterone | 5 / 12 | VAL B 37LEU B 39ILE B 35ILE B 7LEU B 23 | 1.15A | 12.42 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2M2O_B_DHIB24_0 (INSULIN B CHAIN) | L-Histidine | 4 / 6 | PHE A 208PRO A 184LYS A 186THR A 187 | 1.53A | 9.62 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3EM0_A_CHDA151_0 (ILEAL BILEACID-BINDING PROTEIN) | Cholic Acid | 5 / 10 | TYR A 159ILE A 66GLY A 100TYR A 116LEU C 5 | 1.56A | 20.00 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1GTI_D_CCSD47_0 (GLUTATHIONES-TRANSFERASE) | Carbocisteine | 4 / 7 | LEU A 160GLY A 162LYS C 1TYR A 159 | 1.11A | 21.05 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3UA5_B_06XB501_1 (CYTOCHROME P450 2B6) | Amlodipine | 4 / 7 | ILE A 52GLU A 180LEU A 168VAL A 28 | 1.19A | 20.45 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2O4N_A_TPVA300_2 (PROTEASE) | Tipranavir | 4 / 8 | LEU A 270ILE A 213GLY A 207LEU A 266 | 0.92A | 13.14 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2W8Y_A_486A1000_2 (PROGESTERONERECEPTOR) | Mifepristone | 4 / 7 | LEU C 8ASN A 70LEU A 78TYR A 99 | 1.38A | 5.84 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2NNI_A_MTKA501_1 (CYTOCHROME P450 2C8) | Montelukast | 5 / 12 | SER A 77THR A 73THR C 3VAL A 152ALA A 150 | 1.40A | 19.54 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3FI0_B_TRPB1001_0 (TRYPTOPHANYL-TRNASYNTHETASE) | L-Tryptophan | 4 / 8 | HIS A 93ASP A 119ILE B 1VAL B 85 | 1.08A | 20.96 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3UCB_A_017A201_1 (PROTEASE) | Darunavir | 5 / 12 | LEU A 201ASP A 223PRO A 250VAL A 249VAL A 247 | 1.29A | 16.79 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2KOT_B_ANWB99_0 (PROTEIN S100-A13) | Amlexanox | 4 / 8 | ALA A 245VAL A 261THR A 216THR A 258 | 1.50A | 16.48 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1EI6_D_PPFD412_1 (PHOSPHONOACETATEHYDROLASE) | Foscarnet | 4 / 8 | PHE A 33THR A 31ASP A 29HIS A 3 | 1.17A | 22.73 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5BTA_G_MFXG101_1 (DNA GYRASE SUBUNIT ADNA GYRASE SUBUNIT BDNA SUBSTRATE 24-MERTTACGTGCATAGTCATTCATGACC) | Moxifloxacin | 4 / 7 | SER B 33ARG A 82GLY A 91GLU A 89 | 1.15A | 9.5517.39 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1MJL_A_SAMA200_0 (METHIONINE REPRESSORPROTEIN METJ) | S-Adenosylmethionine | 5 / 11 | ALA A 11HIS A 9GLU A 76ARG A 79LEU C 9 | 1.50A | 15.64 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3VN2_A_TLSA501_1 (PEROXISOMEPROLIFERATOR-ACTIVATED RECEPTOR GAMMA) | Telmisartan | 5 / 12 | SER A 67ILE A 66LEU A 32HIS A 9TYR A 74 | 1.68A | 22.02 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4E0F_A_RBFA301_1 (RIBOFLAVIN SYNTHASESUBUNIT ALPHA) | Riboflavin | 5 / 11 | THR A 216GLU A 229ALA A 246THR A 200VAL A 248 | 1.73A | 22.76 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1FE2_A_LAXA700_2 (PROSTAGLANDINENDOPEROXIDE HSYNTHASE-1) | Dihomo-gamma-linolenic acid | 5 / 12 | LEU B 64TYR B 26PHE B 30GLY A 26LEU A 32 | 1.27A | 10.74 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4IG3_A_T27A601_1 (REVERSETRANSCRIPTASE/RIBONUCLEASE H) | Rilpivirine | 5 / 12 | PRO A 235VAL B 82VAL B 9TYR B 66PRO B 5 | 1.51A | 19.18 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5EYP_B_LOCB502_1 (TUBULIN ALPHA CHAINTUBULIN BETA CHAIN) | Colchicine | 3 / 3 | SER A 132ALA A 153VAL A 152 | 0.85A | 21.15 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4UAC_A_ACRA501_2 (CARBOHYDRATE ABCTRANSPORTERSUBSTRATE-BINDINGPROTEIN, CUT1 FAMILY(TC 3.A.1.1.-)) | Acarbose | 4 / 7 | GLU B 50TRP A 60ASP A 61THR A 64 | 1.34A | 12.98 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5KGP_A_GCSA407_1 (PREDICTEDACETYLTRANSFERASE) | Glucosamine | 4 / 8 | ARG A 82PRO A 20GLY A 16PRO A 15 | 1.51A | 20.59 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5CDQ_E_MFXE2101_1 (DNA GYRASE SUBUNIT ADNA GYRASE SUBUNITB,DNA GYRASE SUBUNITB) | Moxifloxacin | 4 / 5 | SER B 33ARG A 82GLY A 91GLU A 89 | 1.32A | 13.2518.97 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5BTA_H_MFXH101_1 (DNA GYRASE SUBUNIT ADNA GYRASE SUBUNIT BDNA SUBSTRATE 24-MERGGTCATGAATGACTATGCACGTAA) | Moxifloxacin | 4 / 6 | SER B 33ARG A 82GLY A 91GLU A 89 | 1.15A | 9.5517.39 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3COT_A_STRA1501_1 (3-OXO-5-BETA-STEROID4-DEHYDROGENASE) | Progesterone | 4 / 7 | TYR A 159GLU A 63TYR A 171TRP A 51 | 1.70A | 21.94 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1XVA_A_SAMA293_0 (GLYCINEN-METHYLTRANSFERASE) | S-Adenosylmethionine | 5 / 12 | HIS A 9ARG A 6GLY A 112TYR A 159TYR A 7 | 1.60A | 22.99 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3K4V_D_ROCD201_2 (HIV-1 PROTEASE) | Saquinavir | 4 / 4 | GLY B 29ASP B 59GLY A 120THR A 10 | 1.11A | 14.68 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1DHF_A_FOLA187_0 (DIHYDROFOLATEREDUCTASE) | Folic Acid | 5 / 12 | ALA C 4GLN A 72THR A 24PRO A 43TYR A 99 | 1.49A | 5.70 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5OV9_B_CVIB602_0 (ACETYLCHOLINESTERASE) | Gentian Violet | 4 / 8 | THR A 216LEU A 215THR A 228VAL A 231 | 1.17A | 19.68 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5A06_D_SORD1343_0 (ALDOSE-ALDOSEOXIDOREDUCTASE) | Sorbitol | 4 / 5 | ALA C 6ARG A 97ALA C 4GLU C 2 | 1.68A | 2.98 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ACA_B_DXCB1473_0 (TRANSLATIONELONGATION FACTORSELB) | Deoxycholic Acid | 5 / 9 | ILE A 213PHE A 208VAL A 231THR A 233GLN A 242 | 1.58A | 18.05 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1FDU_D_ESTD352_1 (17-BETA-HYDROXYSTEROID DEHYDROGENASE) | Estradiol | 4 / 6 | SER A 2VAL A 103GLY A 104GLU A 166 | 1.34A | 20.30 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4C8B_A_0LIA1000_1 (RECEPTOR-INTERACTINGSERINE/THREONINE-PROTEIN KINASE 2) | Ponatinib | 6 / 12 | ALA A 153LEU C 10LEU C 8ILE A 124HIS A 9LEU C 5 | 1.74A | 20.50 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3CFQ_A_DIFA1_1 (TRANSTHYRETIN) | Diclofenac | 4 / 6 | LEU A 147LEU C 10SER A 77THR A 73 | 1.28A | 19.71 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6BC9_A_ETSA302_2 (CARBONIC ANHYDRASE 2) | Dorzolamide | 4 / 5 | GLU A 180HIS A 3LEU A 110VAL A 103 | 1.63A | 21.02 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1N13_H_AG2H7012_1 (PYRUVOYL-DEPENDENTARGININEDECARBOXYLASE ALPHACHAINPYRUVOYL-DEPENDENTARGININEDECARBOXYLASE BETACHAIN) | Agmatine | 4 / 6 | ARG A 6LEU A 110ASP A 102GLY A 100 | 1.52A | 17.7816.23 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4R3A_B_RBFB402_1 (BLUE-LIGHT-ACTIVATEDHISTIDINE KINASE 2) | Riboflavin | 5 / 10 | ILE A 52GLU A 55ASN A 174LEU A 168PHE A 33 | 1.57A | 21.04 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ODJ_A_SAMA500_0 (S-ADENOSYLMETHIONINESYNTHASE) | S-Adenosylmethionine | 4 / 7 | LYS B 58SER B 55PHE A 8ASP A 30 | 1.73A | 12.23 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1NBH_C_SAMC2293_0 (GLYCINEN-METHYLTRANSFERASE) | S-Adenosylmethionine | 5 / 12 | ILE A 52GLY A 26VAL A 34MET A 5TYR A 59 | 1.70A | 22.99 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1N4H_A_REAA500_1 (NUCLEAR RECEPTORROR-BETA) | Tretinoin | 5 / 11 | GLN A 141ILE A 124ALA A 135LEU A 156ALA A 153 | 1.62A | 22.07 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3U5K_B_08JB2_1 (BROMODOMAIN-CONTAINING PROTEIN 4) | Midazolam | 4 / 7 | PRO A 184VAL A 261LEU A 270LEU A 272 | 1.23A | 16.47 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4IV0_B_SAMB302_0 (PHOSPHOETHANOLAMINEN-METHYLTRANSFERASE,PUTATIVE) | S-Adenosylmethionine | 5 / 12 | TYR A 118ILE B 1ARG A 14SER A 92HIS A 93 | 1.46A | 21.94 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6C06_D_FI8D1404_0 (DNA-DIRECTED RNAPOLYMERASE SUBUNITBETADNA-DIRECTED RNAPOLYMERASE SUBUNITBETA') | Fidaxomicin | 4 / 8 | THR A 69GLN A 65THR A 64SER A 38 | 1.42A | 13.69 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6AUU_B_MTLB805_0 (NITRIC OXIDESYNTHASE, BRAIN) | Mannitol | 4 / 8 | GLN A 96PHE A 8ASN A 114TRP B 60 | 1.49A | 20.70 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1E6W_C_ESTC302_1 (SHORT CHAIN3-HYDROXYACYL-COADEHYDROGENASE) | Estradiol | 4 / 4 | ALA A 139GLN A 87TYR A 85LEU C 10 | 1.47A | 21.19 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1D4F_B_ADNB602_1 (S-ADENOSYLHOMOCYSTEINE HYDROLASE) | Adenosine | 5 / 12 | ASP B 34HIS B 51LEU B 64LEU B 54MET A 12 | 1.80A | 12.75 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5UC1_A_486A801_1 (GLUCOCORTICOIDRECEPTOR) | Mifepristone | 5 / 12 | LEU A 130LEU A 160GLY A 162VAL A 165ARG A 6 | 1.28A | 21.77 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2W03_B_ADNB1588_1 (ACSD) | Adenosine | 5 / 10 | LEU A 215HIS A 263PRO A 185LEU A 270GLN A 262 | 1.51A | 18.08 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2XCT_X_CPFX1020_1 (DNA GYRASE SUBUNITB, DNA GYRASESUBUNIT A) | Ciprofloxacin | 4 / 4 | ARG A 82GLY A 91GLU A 89SER B 33 | 1.41A | 18.56 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3H5G_B_LEIB16_0 (COIL SER L16D-PEN) | Penicillamine | 4 / 5 | LEU A 172LYS A 178LEU A 179GLU A 180 | 1.52A | 7.89 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ZZ8_A_GCSA208_1 (GLUCANASE/CHITOSANASE) | Glucosamine | 4 / 7 | GLU A 163ARG A 62TYR A 159GLU A 63 | 1.53A | 17.95 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ZZQ_A_MTLA870_0 (NITRIC-OXIDESYNTHASE, BRAIN) | Mannitol | 4 / 8 | GLN A 96PHE A 8ASN A 114TRP B 60 | 1.56A | 20.38 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4FN9_A_STRA301_1 (STEROID RECEPTOR 2) | Progesterone | 6 / 12 | LEU C 5LEU A 156LEU A 130ALA A 153ALA A 125ARG A 111 | 1.79A | 6.08 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2DDW_B_PXLB1005_1 (PYRIDOXINE KINASE) | Pyridoxal | 4 / 7 | SER A 2LEU A 110HIS A 113ASP A 29 | 1.45A | 22.63 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1CD2_A_FOLA307_1 (DIHYDROFOLATEREDUCTASE) | Folic Acid | 3 / 3 | GLU A 63ILE A 66ARG A 97 | 1.01A | 20.74 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3FC6_A_REAA501_1 (RETINOIC ACIDRECEPTOR RXR-ALPHA) | Tretinoin | 5 / 11 | ALA A 140ALA A 139GLN A 141ALA A 135ILE B 1 | 1.09A | 20.56 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4A9J_A_TYLA1188_1 (BROMODOMAINCONTAINING 2) | Acetaminophen | 4 / 5 | LEU C 5LEU C 8ASN A 70ILE A 66 | 1.39A | 9.52 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ETA_1_T441128_1 (TRANSTHYRETIN) | Levothyroxine | 4 / 5 | LEU A 160GLU A 163ALA A 158LEU A 130 | 1.09A | 19.29 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3RQW_I_ACHI323_0 (ELIC PENTAMERICLIGAND GATED IONCHANNEL FROM ERWINIACHRYSANTHEMI) | Acetylcholine | 5 / 8 | TYR A 99ASN A 114ILE A 66TYR A 159LEU A 160 | 1.52A | 22.26 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4V1F_B_BQ1B1087_0 (F0F1 ATP SYNTHASESUBUNIT C) | Bedaquiline | 5 / 8 | ALA A 135ALA A 136ILE A 124TYR A 123LEU C 10 | 1.65A | 17.11 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5IH0_A_ACTA402_0 (MACROLIDE2'-PHOSPHOTRANSFERASE II) | Acetic acid | 4 / 6 | PHE A 33PRO A 47ARG A 239ILE A 52 | 1.71A | 21.50 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1J96_A_TESA903_1 (3ALPHA-HYDROXYSTEROID DEHYDROGENASE TYPE3) | Testosterone | 4 / 6 | TYR A 159VAL A 34ILE A 52TRP A 167 | 1.70A | 20.66 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1NX9_A_AICA5001_1 (ALPHA-AMINO ACIDESTER HYDROLASE) | Ampicillin | 4 / 8 | TYR A 59ARG A 62GLU A 63TYR A 159 | 1.36A | 19.10 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4K36_B_SAMB504_0 (ANAEROBICSULFATASE-MATURATINGENZYME) | S-Adenosylmethionine | 5 / 12 | ASN B 24LEU B 64VAL B 37ILE B 35LEU B 87 | 1.59A | 13.61 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5L17_A_ZMRA512_1 (NEURAMINIDASE) | Zanamivir | 5 / 12 | ARG A 97ARG A 62GLU C 2GLU A 163TYR A 99 | 1.73A | 20.97 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4D39_B_MTLB870_0 (NITRIC OXIDESYNTHASE,ENDOTHELIAL) | Mannitol | 4 / 7 | ARG A 170ASN A 174GLU A 53ILE A 52 | 1.44A | 21.63 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1UKB_A_BEZA1301_0 (2-HYDROXY-6-OXO-7-METHYLOCTA-2,4-DIENOATE HYDROLASE) | Benzoic Acid | 4 / 6 | ARG A 97LEU A 130ALA A 153LEU A 160 | 1.43A | 23.48 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2GLU_B_SAMB302_0 (YCGJ) | S-Adenosylmethionine | 5 / 12 | HIS A 93ALA A 136THR A 134ALA A 125ALA A 117 | 1.36A | 21.12 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2YFB_A_ACTA501_0 (METHYL-ACCEPTINGCHEMOTAXISTRANSDUCER) | Acetic acid | 4 / 7 | ARG A 48VAL A 25ARG A 35ILE A 23 | 1.21A | 23.05 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4A6E_A_SAMA1349_0 (HYDROXYINDOLEO-METHYLTRANSFERASE) | S-Adenosylmethionine | 5 / 12 | LEU A 172GLY A 104GLY A 107VAL A 165ASP A 29 | 1.62A | 20.89 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5TRQ_B_ACTB307_0 (WELO5) | Acetic acid | 3 / 3 | GLU B 50HIS B 51VAL B 49 | 1.59A | 16.67 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4O2B_B_LOCB503_1 (TUBULIN ALPHA-1BCHAINTUBULIN BETA-2BCHAIN) | Colchicine | 3 / 3 | SER A 132ALA A 153VAL A 152 | 0.95A | 21.15 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3HVT_A_NVPA557_1 (HIV-1 REVERSETRANSCRIPTASE(SUBUNIT P66)) | Nevirapine | 5 / 9 | LEU A 95TYR A 118TYR A 123LEU C 10TYR A 74 | 1.78A | 19.78 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4QZU_B_RTLB201_0 (RETINOL-BINDINGPROTEIN 2) | Vitamin A | 5 / 12 | PHE A 208THR A 187ARG A 202LEU A 215LEU A 266 | 1.62A | 18.87 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3BSZ_F_RTLF178_0 (PLASMARETINOL-BINDINGPROTEIN) | Vitamin A | 5 / 11 | LEU C 9PHE A 22ALA A 11TYR A 116HIS A 9 | 1.52A | 8.82 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2F7A_A_BEZA1003_0 (HTH-TYPETRANSCRIPTIONALREGULATOR BENM) | Benzoic Acid | 5 / 9 | LEU C 8LEU C 9LEU A 95ARG A 97TYR A 116 | 1.40A | 4.79 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3HAV_A_SRYA403_1 (AMINOGLYCOSIDEPHOSPHOTRANSFERASE) | Streptomycin | 4 / 8 | ASP B 53ASP A 39ASP B 34TYR B 66 | 1.31A | 17.54 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3KO0_B_TFPB202_1 (PROTEIN S100-A4) | Trifluoperazine | 3 / 3 | GLU A 128LEU A 130ASP A 129 | 1.23A | 15.09 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2M2P_B_DHIB24_0 (INSULIN B CHAIN) | L-Histidine | 3 / 3 | TYR A 209GLY A 207PHE A 241 | 1.16A | 9.62 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4L39_B_SALB601_1 (4-SUBSTITUTEDBENZOATES-GLUTAMATELIGASE GH3.12) | Salicylic acid | 4 / 7 | LEU A 81TYR A 123ILE A 142GLY A 83 | 1.37A | 19.29 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6BSJ_A_EFZA601_1 (REVERSETRANSCRIPTASE P66SUBUNIT) | Efavirenz | 5 / 10 | LEU A 95TYR A 118TYR A 123LEU C 10TYR A 74 | 1.75A | 19.93 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2CML_C_ZMRC3477_1 (NEURAMINIDASE) | Zanamivir | 5 / 12 | ARG A 97ARG A 62GLU C 2GLU A 163TYR A 99 | 1.70A | 19.14 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6B89_B_NOVB403_1 (LIPOPOLYSACCHARIDEEXPORT SYSTEMATP-BINDING PROTEINLPTB) | Novobiocin | 4 / 7 | ARG A 75LEU A 78GLN A 87GLN A 72 | 1.44A | 23.88 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3N58_A_ADNA500_1 (ADENOSYLHOMOCYSTEINASE) | Adenosine | 5 / 12 | LEU A 168LEU A 110LEU A 109GLY A 112HIS A 113 | 1.52A | 19.49 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2BXG_B_IBPB2002_1 (SERUM ALBUMIN) | Ibuprofen | 5 / 10 | ALA A 246ALA A 245ALA A 205LEU A 201VAL A 189 | 1.46A | 19.35 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5WWS_A_SAMA501_0 (PUTATIVEMETHYLTRANSFERASENSUN6) | S-Adenosylmethionine | 5 / 12 | GLY A 18ASP B 34ASP A 39LEU B 64LEU B 54 | 1.49A | 21.70 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3MBH_A_PXLA400_1 (PUTATIVEPHOSPHOMETHYLPYRIMIDINE KINASE) | Pyridoxal | 5 / 11 | LEU A 95HIS A 93GLN A 87TYR A 123TYR A 85 | 1.54A | 22.33 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4QB9_E_PARE500_1 (ENHANCEDINTRACELLULARSURVIVAL PROTEIN) | Paromomycin | 5 / 12 | SER B 52LEU A 32TYR A 27ASP A 30GLY A 237 | 1.60A | 11.11 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ZJL_D_ERYD1101_0 (MULTIDRUG EFFLUXPUMP SUBUNIT ACRB) | Erythromycin | 5 / 12 | SER A 67ARG A 62GLU A 63GLU C 2MET A 98 | 1.74A | 13.61 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3CYX_A_ROCA201_2 (HIV-1 PROTEASE) | Saquinavir | 3 / 3 | ARG A 181VAL A 28THR A 31 | 1.49A | 14.23 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1MZ9_D_VDYD1001_3 (CARTILAGE OLIGOMERICMATRIX PROTEIN) | Calcidiol | 3 / 3 | THR A 94LEU A 95LEU C 8 | 0.98A | 12.16 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5LRB_A_ACRA1003_1 (ALPHA-1,4 GLUCANPHOSPHORYLASE) | Acarbose | 4 / 6 | THR A 73TYR A 74TYR A 99PHE B 56 | 1.47A | 14.41 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3VW7_A_VPXA2001_1 (PROTEINASE-ACTIVATEDRECEPTOR 1, LYSOZYME) | Vorapaxar | 5 / 12 | TYR A 123LEU C 8LEU A 78LEU A 81ALA A 11 | 1.44A | 19.17 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4KOV_A_KOVA204_1 (UNCHARACTERIZEDPROTEIN) | Cefuroxime | 5 / 12 | TYR A 159GLY A 100ASN A 114MET A 98ARG A 62 | 1.76A | 21.58 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3B0W_A_DGXA1_2 (NUCLEAR RECEPTORROR-GAMMA) | Digoxin | 3 / 3 | TRP A 51VAL A 103ARG A 108 | 1.13A | 20.63 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5HS6_A_J3ZA302_1 (17-BETA-HYDROXYSTEROID DEHYDROGENASE 14) | Estrone | 4 / 8 | HIS A 260GLN A 218LEU A 272THR A 228 | 1.49A | 21.72 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1L7X_A_CFFA863_1 (GLYCOGENPHOSPHORYLASE, LIVERFORM) | Caffeine | 5 / 6 | ASN B 24PHE B 22HIS B 13ALA A 236GLY A 237 | 1.77A | 6.88 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4O8F_A_BRLA501_1 (PEROXISOMEPROLIFERATOR-ACTIVATED RECEPTOR GAMMA) | Rosiglitazone | 5 / 12 | PHE A 22ARG A 79SER A 77LEU A 95TYR A 116 | 1.63A | 21.56 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5IK1_A_CAMA502_0 (CAMPHOR5-MONOOXYGENASE) | Camphor | 4 / 5 | LEU A 32GLY A 26ASP A 37ILE A 23 | 1.50A | 20.62 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5UMW_B_RBFB201_1 (GLYOXALASE/BLEOMYCINRESISANCEPROTEIN/DIOXYGENASE) | Riboflavin | 4 / 7 | VAL A 165ARG A 157GLU A 161LEU A 126 | 1.79A | 22.26 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4KRH_A_SAMA900_0 (PHOSPHOETHANOLAMINEN-METHYLTRANSFERASE2) | S-Adenosylmethionine | 5 / 12 | PHE B 56TYR A 99GLY A 26HIS A 9ILE A 23 | 1.52A | 10.90 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4RYA_A_MTLA501_1 (ABC TRANSPORTERSUBSTRATE BINDINGPROTEIN (SORBITOL)) | Mannitol | 3 / 3 | GLU A 63TYR A 159GLU A 163 | 1.25A | 20.29 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1QZR_B_CDXB901_1 (DNA TOPOISOMERASE II) | Dexrazoxane | 4 / 7 | THR A 73TYR A 74TYR A 116LEU A 95 | 1.12A | 20.71 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5NNW_D_GCSD302_1 (25 KDA PROTEINELICITOR) | Glucosamine | 4 / 7 | GLY A 120HIS B 31HIS A 93ASP A 119 | 1.72A | 20.29 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4D33_A_MTLA870_0 (NITRIC OXIDESYNTHASE,ENDOTHELIAL) | Mannitol | 4 / 8 | ARG A 170ASN A 174GLU A 53ILE A 52 | 1.49A | 21.63 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1FDS_A_ESTA350_1 (17-BETA-HYDROXYSTEROID-DEHYDROGENASE) | Estradiol | 5 / 12 | SER A 4VAL A 28SER B 55PHE A 8PHE A 33 | 1.69A | 20.30 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6GH9_A_MIXA1003_0 (UBIQUITINCARBOXYL-TERMINALHYDROLASE 15) | Mitoxantrone | 4 / 5 | TYR A 85GLY A 83HIS A 93ASP A 119 | 1.48A | 19.89 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2OTF_A_2TNA201_1 (PHOSPHOLIPASE A2VRV-PL-VIIIA) | Atenolol | 4 / 5 | LEU B 54SER B 28GLY B 29HIS B 84 | 1.56A | 23.77 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5KM8_B_L8PB201_1 (HISTIDINE TRIADNUCLEOTIDE-BINDINGPROTEIN 2,MITOCHONDRIAL) | Cidofovir | 4 / 8 | TRP A 133GLN A 144ALA A 153GLN A 155 | 1.44A | 19.78 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3QL6_A_NIMA614_1 (LACTOPEROXIDASE) | Nimesulide | 4 / 7 | GLN A 115GLU C 2ARG A 6PHE B 56 | 1.65A | 17.89 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1KT7_A_RTLA184_0 (PLASMARETINOL-BINDINGPROTEIN) | Vitamin A | 5 / 11 | LEU C 5LEU A 147ALA A 136VAL A 152LEU A 126 | 1.57A | 6.17 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1KIA_A_ACTA294_0 (GLYCINEN-METHYLTRANSFERASE) | Acetic acid | 4 / 6 | ASN A 70TYR A 99TYR A 116TYR A 74 | 1.56A | 22.99 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1XIU_A_9CRA201_1 (RXR-LIKE PROTEIN) | Alitretinoin | 5 / 12 | ILE A 124ALA A 140ALA A 135GLN A 141ARG A 145 | 1.53A | 22.07 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4IKJ_A_SUZA201_1 (TRANSTHYRETIN) | Sulindac | 4 / 7 | LEU A 147LEU C 10SER A 77THR A 73 | 1.28A | 19.29 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5YJ1_K_6ELK501_0 (PROTEIN CEREBLON) | Thalidomide | 4 / 7 | HIS A 113TRP B 60PHE B 56THR A 134 | 1.70A | 13.55 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1NBH_A_SAMA293_0 (GLYCINEN-METHYLTRANSFERASE) | S-Adenosylmethionine | 5 / 12 | ILE A 52GLY A 26VAL A 34MET A 5TYR A 59 | 1.70A | 22.99 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1I00_A_D16A315_1 (THYMIDYLATE SYNTHASE) | Raltitrexed | 5 / 9 | PHE A 33GLU A 55ILE A 52LEU A 179GLY A 175 | 1.75A | 21.57 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4TZC_D_EF2D505_1 (PROTEIN CEREBLON) | Thalidomide | 4 / 8 | THR A 134HIS A 113TRP B 60PHE B 56 | 1.69A | 13.70 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2Y6O_A_1N1A1892_1 (EPHRIN TYPE-ARECEPTOR 4) | Dasatinib | 5 / 12 | ILE A 213ALA A 205THR A 187GLY A 265LEU A 266 | 1.38A | 21.05 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6BXN_A_SAMA901_0 (DIPHTHAMIDEBIOSYNTHESIS ENZYMEDPH2) | S-Adenosylmethionine | 5 / 12 | LEU A 206HIS A 188VAL B 93ASP B 98ASP B 96 | 1.80A | 20.60 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1N4F_A_ASRA140_0 (LYSOZYME C) | Arsanilic acid | 3 / 3 | ASN A 114ALA A 125ASN A 127 | 1.34A | 16.30 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4TWD_H_377H401_1 (CYS-LOOPLIGAND-GATED IONCHANNEL) | Memantine | 4 / 6 | TYR A 171GLU A 55GLU A 63TYR A 7 | 1.27A | 21.65 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3FI0_Q_TRPQ1001_0 (TRYPTOPHANYL-TRNASYNTHETASE) | L-Tryptophan | 4 / 8 | HIS A 93ASP A 119ILE B 1VAL B 85 | 1.09A | 20.96 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ZJI_A_PQNA844_1 (PHOTOSYSTEM I P700CHLOROPHYLL AAPOPROTEIN A1PHOTOSYSTEM IREACTION CENTERSUBUNIT IX) | Phylloquinone | 5 / 10 | SER A 2GLY A 104ARG A 169LEU A 168PHE A 22 | 1.61A | 16.158.44 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4Q0D_C_MTXC604_1 (BIFUNCTIONALDIHYDROFOLATEREDUCTASE-THYMIDYLATE SYNTHASE) | Methotrexate | 5 / 12 | LEU A 147LEU A 126SER A 143TYR A 74THR C 3 | 1.66A | 18.92 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3RI5_A_IVMA349_0 (AVERMECTIN-SENSITIVEGLUTAMATE-GATEDCHLORIDE CHANNELGLUCL ALPHA) | Ivermectin | 5 / 13 | ILE B 7PRO B 5THR B 86ASN B 83ILE B 92 | 1.51A | 16.94 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4AC9_C_DXCC1479_0 (MJ0495-LIKE PROTEIN) | Deoxycholic Acid | 4 / 5 | THR C 3ILE A 66GLU A 63PHE A 22 | 1.49A | 2.00 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2FK8_A_SAMA302_1 (METHOXY MYCOLIC ACIDSYNTHASE 4) | S-Adenosylmethionine | 3 / 3 | SER A 92THR B 86GLN B 2 | 0.96A | 25.89 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2E7F_A_C2FA3000_0 (5-METHYLTETRAHYDROFOLATE CORRINOID/IRONSULFUR PROTEINMETHYLTRANSFERASE) | Levomefolic acid | 5 / 12 | GLU C 2ASN A 114LEU C 10SER A 67ASN A 70 | 1.51A | 3.72 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3J6P_B_TA1B502_1 (TUBULIN BETA CHAIN) | Paclitaxel | 5 / 12 | LEU A 95HIS A 9PHE B 56THR A 94LEU B 54 | 1.64A | 19.46 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4R38_A_RBFA201_1 (BLUE-LIGHT-ACTIVATEDHISTIDINE KINASE 2) | Riboflavin | 5 / 12 | ALA A 205GLN B 8ILE A 213ASN B 24GLY A 207 | 1.63A | 18.71 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4TWD_C_377C401_1 (CYS-LOOPLIGAND-GATED IONCHANNEL) | Memantine | 4 / 6 | TYR A 7GLU A 163TYR A 159LEU C 5 | 1.71A | 21.65 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5EEI_A_SHHA2004_1 (HDAC6 PROTEIN) | Vorinostat | 5 / 12 | PRO A 43SER A 67PHE A 36PHE A 22ASP A 39 | 1.73A | 20.98 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4DX7_A_DM2A1106_1 (ACRIFLAVINERESISTANCE PROTEIN B) | Epirubicin | 5 / 11 | SER A 67MET A 5PHE A 33ARG A 170GLN A 54 | 1.45A | 13.61 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1P7R_A_NCTA440_1 (CYTOCHROME P450-CAM) | Nicotine | 4 / 7 | THR A 10VAL A 25ASP B 53ILE A 23 | 1.10A | 20.62 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3S56_B_ROCB203_1 (PROTEASE) | Saquinavir | 4 / 7 | GLU B 50LEU B 39GLU B 47ILE B 46 | 1.28A | 15.24 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ND7_B_TA1B601_2 (TUBULIN BETA-2BCHAIN) | Paclitaxel | 3 / 3 | THR A 69PRO A 20ARG A 21 | 1.28A | 19.46 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4XK8_A_PQNA845_1 (PHOTOSYSTEM I P700CHLOROPHYLL AAPOPROTEIN A1) | Phylloquinone | 4 / 8 | MET A 5ARG A 239ALA A 49LEU A 32 | 1.39A | 15.29 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3U5K_A_08JA1_1 (BROMODOMAIN-CONTAINING PROTEIN 4) | Midazolam | 4 / 8 | PRO A 184VAL A 261LEU A 270LEU A 272 | 1.16A | 16.47 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5Y2T_A_8LXA501_1 (PEROXISOMEPROLIFERATOR-ACTIVATED RECEPTOR GAMMA) | Lobeglitazone | 3 / 3 | SER A 13HIS A 93TYR A 118 | 1.32A | 21.79 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3H5G_A_LEIA16_0 (COIL SER L16D-PEN) | Penicillamine | 4 / 6 | GLN A 72LEU C 7GLU A 76LEU C 9 | 1.58A | 7.89 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5A06_A_SORA1341_0 (ALDOSE-ALDOSEOXIDOREDUCTASE) | Sorbitol | 4 / 7 | PHE A 241ASP A 30TYR A 27TYR B 63 | 1.79A | 20.22 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4MJ8_B_SPMB201_1 (SPERMIDINEN1-ACETYLTRANSFERASE) | Spermine | 4 / 8 | GLU A 53GLU A 55TYR A 171ARG A 170 | 1.63A | 20.58 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4IMA_D_ADND604_1 (PYRUVATE KINASE) | Adenosine | 3 / 3 | ARG A 170GLU A 55ASN A 174 | 1.65A | 19.04 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6F6S_A_CXQA507_1 (ENVELOPEGLYCOPROTEIN,ENVELOPE GLYCOPROTEIN,GP1ENVELOPEGLYCOPROTEIN) | Benzatropine | 4 / 5 | ALA A 135TYR A 123GLN A 141ILE A 142 | 1.37A | 23.0824.21 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3TQ8_A_TOPA2001_1 (DIHYDROFOLATEREDUCTASE) | Trimethoprim | 5 / 9 | ALA A 139LEU A 81ASP A 137ILE A 124THR A 138 | 1.64A | 17.56 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4MWZ_B_SAMB301_0 (PHOSPHOETHANOLAMINEN-METHYLTRANSFERASE,PUTATIVE) | S-Adenosylmethionine | 5 / 12 | VAL B 37ILE A 23ILE B 35SER B 52HIS B 51 | 1.40A | 17.49 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1A4G_B_ZMRB466_1 (NEURAMINIDASE) | Zanamivir | 5 / 12 | ARG A 97ARG A 62GLU C 2GLU A 163TYR A 99 | 1.72A | 21.71 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4A6D_A_SAMA1350_0 (HYDROXYINDOLEO-METHYLTRANSFERASE) | S-Adenosylmethionine | 5 / 12 | LEU A 172GLY A 104GLY A 107VAL A 165ASP A 29 | 1.56A | 20.89 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ZVG_A_SAMA401_1 (389AA LONGHYPOTHETICALNUCLEOLAR PROTEIN) | S-Adenosylmethionine | 3 / 3 | ASP A 183ARG A 181ASP A 238 | 1.63A | 20.26 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2W03_A_ADNA1588_1 (ACSD) | Adenosine | 5 / 10 | LEU A 215HIS A 263PRO A 185LEU A 270GLN A 262 | 1.52A | 18.08 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4TWD_F_377F401_1 (CYS-LOOPLIGAND-GATED IONCHANNEL) | Memantine | 4 / 7 | GLU B 36TYR B 66LEU B 39ARG B 81 | 1.41A | 16.29 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3AVP_A_MV2A313_1 (PANTOTHENATE KINASE) | Dexpanthenol | 4 / 7 | ASP A 119HIS B 31LEU A 78ILE A 23 | 1.15A | 22.19 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1WSV_A_THHA3001_1 (AMINOMETHYLTRANSFERASE) | Levomefolic acid | 3 / 3 | ASP A 30GLU A 232TYR B 10 | 1.51A | 22.53 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3BOY_A_HISA1001_0 (HUT OPERON POSITIVEREGULATORY PROTEIN) | L-Histidine | 5 / 10 | ILE B 1GLY A 120ALA A 117TYR A 118HIS A 93 | 1.51A | 18.83 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2AW1_A_COXA264_1 (CARBONIC ANHYDRASEII) | Valdecoxib | 5 / 12 | ILE A 124HIS B 31LEU A 81LEU A 95THR A 94 | 1.59A | 21.09 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3OAP_A_9CRA500_1 (RETINOIC ACIDRECEPTOR RXR-ALPHA) | Alitretinoin | 5 / 12 | ALA A 140ALA A 139GLN A 141ALA A 135ILE B 1 | 1.17A | 20.57 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ACB_C_DXCC1479_0 (TRANSLATIONELONGATION FACTORSELB) | Deoxycholic Acid | 4 / 5 | THR B 68ILE B 46LYS B 48GLU B 47 | 1.60A | 12.71 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3RC0_A_SAMA484_0 (N-LYSINEMETHYLTRANSFERASESETD6) | S-Adenosylmethionine | 5 / 11 | GLY A 237ALA B 15ASN B 24LEU B 39PHE B 70 | 1.62A | 19.61 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3RD0_A_EDPA175_1 (FERRITIN LIGHT CHAIN) | Thiopental | 4 / 6 | LEU C 10TYR A 118ALA A 139LEU A 95 | 1.43A | 17.07 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4TXN_A_URFA302_1 (URIDINEPHOSPHORYLASE) | Fluorouracil | 4 / 7 | THR A 187GLY A 207GLN A 242ILE A 213 | 1.37A | 18.01 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5YIZ_G_EF2G501_1 (PROTEIN CEREBLON) | Thalidomide | 4 / 7 | HIS A 113TRP B 60PHE B 56THR A 134 | 1.71A | 13.55 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5HNX_B_TA1B902_1 (TUBULIN BETA-2BCHAIN) | Paclitaxel | 5 / 12 | HIS A 9PHE B 56THR A 94ARG A 75ARG A 35 | 1.63A | 19.46 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3GWU_A_SREA801_1 (TRANSPORTER) | Sertraline | 5 / 12 | LEU A 160LEU A 130TYR A 159ALA A 153LEU C 8 | 1.51A | 21.47 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4QMN_A_DB8A401_1 (SERINE/THREONINE-PROTEIN KINASE 24) | Bosutinib | 5 / 12 | ILE A 213ALA A 205LYS A 186ALA A 236ASP A 238 | 1.50A | 19.63 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4A97_I_ZPCI1318_2 (CYS-LOOPLIGAND-GATED IONCHANNEL) | Eszopiclone | 4 / 6 | GLU A 63ILE A 66TYR A 159VAL A 103 | 1.36A | 21.65 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3CE6_D_ADND500_2 (ADENOSYLHOMOCYSTEINASE) | Adenosine | 4 / 5 | GLN A 96THR A 10HIS B 51LEU B 64 | 1.68A | 21.29 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2PRG_B_BRLB2_1 (PEROXISOMEPROLIFERATORACTIVATED RECEPTORGAMMA) | Rosiglitazone | 5 / 12 | PHE A 22SER A 77LEU C 7LEU A 95TYR A 116 | 1.54A | 22.04 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6E5Z_A_CCSA106_0 (PROTEIN/NUCLEIC ACIDDEGLYCASE DJ-1) | Carbocisteine | 5 / 10 | GLY A 207ALA A 205PRO A 185THR A 187HIS A 188 | 1.65A | 22.02 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4LG1_B_SAMB301_0 (PROTEIN-LYSINEMETHYLTRANSFERASEMETTL21D) | S-Adenosylmethionine | 5 / 12 | GLY A 112LEU A 156LEU A 160TRP A 133TYR A 116 | 1.33A | 22.61 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2AVV_E_MK1E902_4 (POL POLYPROTEIN) | Indinavir | 3 / 3 | ARG A 157VAL A 165GLY A 104 | 0.90A | 14.23 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3G89_B_SAMB303_0 (RIBOSOMAL RNA SMALLSUBUNITMETHYLTRANSFERASE G) | S-Adenosylmethionine | 5 / 11 | GLY A 207ALA A 205THR A 187ARG A 181ALA A 182 | 1.55A | 23.08 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1T6Z_A_RBFA296_1 (RIBOFLAVINKINASE/FMNADENYLYLTRANSFERASE) | Riboflavin | 5 / 11 | VAL A 165VAL A 103GLU A 161ARG A 169GLU A 166 | 1.68A | 19.44 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5HI6_A_MTXA201_1 (DIHYDROFOLATEREDUCTASE) | Methotrexate | 5 / 12 | LEU A 126SER A 143ILE A 124TYR A 74THR C 3 | 1.62A | 19.64 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4Z4E_A_IPHA906_0 (PROTEIN ARGONAUTE-2) | Phenol | 4 / 5 | PHE A 33PRO A 47VAL A 34ALA A 49 | 1.51A | 15.37 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4PAH_A_LNRA600_1 (PHENYLALANINEHYDROXYLASE) | Norepinephrine | 4 / 6 | LEU A 32PHE A 33HIS A 9GLU C 2 | 1.69A | 21.86 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3W6H_A_AZMA303_1 (CARBONIC ANHYDRASE 1) | Acetazolamide | 4 / 8 | HIS A 192LEU A 201THR A 190HIS A 191 | 1.75A | 25.17 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4KIC_B_SAMB401_1 (METHYLTRANSFERASEMPPJ) | S-Adenosylmethionine | 3 / 3 | ARG A 145ASP A 137ASP A 122 | 1.77A | 20.67 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ACL_A_REAA502_1 (RETINOIC ACIDRECEPTOR RXR-ALPHA) | Tretinoin | 5 / 12 | ALA A 140ALA A 139GLN A 141ALA A 135ILE B 1 | 1.12A | 20.42 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4OGR_A_ADNA401_1 (CYCLIN-DEPENDENTKINASE 9) | Adenosine | 4 / 8 | ILE A 52GLY A 26ALA A 49LEU A 179 | 1.05A | 22.70 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5EEN_B_5OGB804_1 (HDAC6 PROTEIN) | Belinostat | 5 / 12 | PRO A 43SER A 67PHE A 36PHE A 22ASP A 39 | 1.74A | 20.98 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5XIP_C_HFGC1003_0 (PROLYL-TRNASYNTHETASE, PUTATIVE) | Halofuginone | 5 / 12 | LEU A 160THR C 3GLU C 2HIS A 9THR A 69 | 1.66A | 21.23 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4YVP_A_GBMA402_1 (ALDO-KETO REDUCTASEFAMILY 1 MEMBER C1) | Glyburide | 5 / 11 | TYR A 74LEU C 10ILE A 124HIS A 9LEU A 156 | 1.43A | 21.07 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4G10_A_ACTA301_0 (GLUTATHIONES-TRANSFERASEHOMOLOG) | Acetic acid | 4 / 6 | ILE A 66TYR A 159TYR A 7TYR A 99 | 1.61A | 23.49 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5HFJ_A_SAMA301_0 (ADENINE SPECIFIC DNAMETHYLTRANSFERASE(DPNA)) | S-Adenosylmethionine | 5 / 12 | ALA A 205ASP A 183PHE A 208GLY A 265GLU A 212 | 1.75A | 21.07 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2BXE_B_1FLB2002_1 (SERUM ALBUMIN) | Diflunisal | 5 / 11 | ALA A 246ALA A 245ALA A 205LEU A 201VAL A 189 | 1.46A | 19.35 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2MJI_A_KTRA201_1 (FATTY ACID-BINDINGPROTEIN, INTESTINAL) | Ketorolac | 5 / 12 | TYR A 99GLU A 63TYR A 171LEU A 168TYR A 159 | 1.60A | 20.49 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4QC6_A_KANA201_1 (BIFUNCTIONAL AAC/APH) | Kanamycin | 5 / 11 | TYR A 209HIS A 3ASP A 30HIS A 263GLU A 264 | 1.61A | 18.90 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6FNM_A_1N1A1001_1 (-) | Dasatinib | 5 / 12 | ILE A 213ALA A 205THR A 187GLY A 265LEU A 266 | 1.55A | 21.50 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4AWU_A_4CHA502_0 (OXIDOREDUCTASE,FMN-BINDING) | Parachlorophenol | 4 / 7 | ASN B 24TYR B 10LEU B 65PHE A 241 | 1.42A | 14.05 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5PHH_A_LDPA414_1 (LYSINE-SPECIFICDEMETHYLASE 4D) | Dopamine | 4 / 6 | GLU A 254ALA A 199LEU A 201SER A 251 | 1.73A | 23.32 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5VUN_A_MTLA805_0 (NITRIC OXIDESYNTHASE, BRAIN) | Mannitol | 4 / 8 | GLN A 96PHE A 8ASN A 114TRP B 60 | 1.49A | 20.70 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5J2T_C_VLBC503_1 (TUBULIN BETA-2BCHAINTUBULIN ALPHA-1BCHAIN) | Vinblastine | 5 / 9 | TYR A 74PHE A 22THR A 10TYR A 118LEU A 78 | 1.79A | 18.98 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4IKL_B_SUZB201_1 (TRANSTHYRETIN) | Sulindac | 4 / 8 | LEU A 147LEU C 10SER A 77THR A 73 | 1.28A | 19.29 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2OA1_A_TRPA2002_0 (TRYPTOPHANHALOGENASE) | L-Tryptophan | 5 / 12 | PRO A 43ILE A 66PHE A 36GLU A 63GLU A 46 | 1.58A | 20.40 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3RUK_D_AERD601_1 (STEROID17-ALPHA-HYDROXYLASE/17,20 LYASE) | Abiraterone | 5 / 11 | ALA A 40TYR A 74ASN A 70ASP A 37THR A 64 | 1.25A | 21.00 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4A97_A_ZPCA1318_1 (CYS-LOOPLIGAND-GATED IONCHANNEL) | Eszopiclone | 4 / 7 | GLU A 63ILE A 66TYR A 159VAL A 103 | 1.34A | 21.65 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5OGC_B_TA1B601_1 (TUBULIN BETA CHAIN) | Paclitaxel | 5 / 12 | VAL A 103ASP A 102THR C 3GLY A 112LEU A 160 | 1.66A | 19.46 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ADS_A_IMNA1_1 (PEROXISOMEPROLIFERATOR-ACTIVATED RECEPTOR GAMMA) | Indomethacin | 5 / 10 | GLU A 46ARG A 35GLY A 26LEU A 179ILE A 52 | 1.56A | 21.88 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1VAO_A_ACTA601_0 (VANILLYL-ALCOHOLOXIDASE) | Acetic acid | 4 / 5 | TYR A 7PHE A 33ILE A 52TYR A 59 | 1.80A | 18.87 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4WQ4_A_ACTA403_0 (TRNA N6-ADENOSINETHREONYLCARBAMOYLTRANSFERASE) | Acetic acid | 3 / 3 | VAL A 247LEU A 201VAL A 249 | 0.90A | 20.99 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2NNK_A_ROCA401_1 (PROTEASE) | Saquinavir | 5 / 12 | LEU A 201ASP A 223PRO A 250VAL A 249VAL A 247 | 1.26A | 14.62 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ACL_E_REAE504_1 (RETINOIC ACIDRECEPTOR RXR-ALPHA) | Tretinoin | 5 / 11 | ALA A 140ALA A 139GLN A 141ALA A 135ILE B 1 | 1.03A | 20.42 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5OV9_A_CVIA608_0 (ACETYLCHOLINESTERASE) | Gentian Violet | 4 / 7 | THR A 216LEU A 215THR A 228VAL A 231 | 1.15A | 19.68 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1RS6_A_MTLA870_0 (NITRIC-OXIDESYNTHASE, BRAIN) | Mannitol | 4 / 8 | GLN A 96PHE A 8ASN A 114TRP B 60 | 1.59A | 20.70 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1NBH_A_ACTA294_0 (GLYCINEN-METHYLTRANSFERASE) | Acetic acid | 4 / 6 | ASN A 70TYR A 99TYR A 116TYR A 74 | 1.55A | 22.99 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3BJW_B_SVRB512_1 (PHOSPHOLIPASE A2) | Suramin | 4 / 5 | VAL A 231THR A 228THR A 233ARG A 234 | 1.56A | 16.35 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5BW4_B_SAMB301_1 (16S RRNA(ADENINE(1408)-N(1))-METHYLTRANSFERASE) | S-Adenosylmethionine | 3 / 3 | ASP B 53GLU B 50SER A 67 | 1.61A | 15.67 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1HXB_A_ROCA100_4 (HIV-1 PROTEASE) | Saquinavir | 4 / 4 | GLY B 29ASP B 59GLY A 120THR A 10 | 1.04A | 16.38 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3UFN_A_ROCA402_1 (HIV-1 PROTEASE) | Saquinavir | 4 / 5 | LEU A 168PRO A 105VAL A 103ASP A 29 | 1.62A | 16.79 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6HCX_A_ZMRA519_0 (NEURAMINIDASE) | Zanamivir | 5 / 12 | ARG A 97ARG A 62GLU C 2GLU A 163TYR A 99 | 1.75A | 20.95 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1PG2_A_ADNA552_1 (METHIONYL-TRNASYNTHETASE) | Adenosine | 5 / 11 | ALA C 4GLU A 163GLY C 1ILE A 66TYR A 59 | 1.66A | 2.01 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2XAD_E_GCSE710_1 (N-ACYL GLMPEUDO-TEICOPLANINDEACETYLASETEICOPLANIN) | Glucosamine | 4 / 8 | ARG A 35ASP B 53ILE A 23HIS B 51 | 1.65A | 22.56 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5AYF_A_C7HA402_1 (HISTONE-LYSINEN-METHYLTRANSFERASESETD7) | Cyproheptadine | 4 / 5 | TYR A 118GLY A 83TYR A 123TYR A 84 | 1.33A | 19.79 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1NW5_A_SAMA401_1 (MODIFICATIONMETHYLASE RSRI) | S-Adenosylmethionine | 3 / 3 | ASP A 220HIS A 260ASP A 223 | 1.09A | 22.42 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3WQW_A_GCSA501_1 (CHITINASE) | Glucosamine | 5 / 11 | PHE A 33GLU A 63TYR A 159TYR A 99ARG A 97 | 1.76A | 21.87 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4Z2D_F_LFXF102_1 (DNA GYRASE SUBUNIT ADNA GYRASE SUBUNIT BSYMMETRIZED E-SITEDNA) | Levofloxacin | 3 / 4 | ARG A 219GLY A 221GLU A 222 | 1.46A | 19.0921.94 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4V04_B_0LIB1771_1 (FIBROBLAST GROWTHFACTOR RECEPTOR 1(FMS-RELATEDTYROSINE KINASE 2,PFEIFFER SYNDROME),ISOFORM CRA_B) | Ponatinib | 5 / 10 | LEU A 95ILE A 124TYR A 118ARG A 157LEU A 156 | 1.66A | 22.36 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4TWD_G_377G401_1 (CYS-LOOPLIGAND-GATED IONCHANNEL) | Memantine | 4 / 6 | TYR A 7GLU A 163TYR A 159LEU C 5 | 1.56A | 21.65 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1EQB_A_FFOA1293_2 (SERINEHYDROXYMETHYLTRANSFERASE) | Levoleucovorin | 3 / 3 | SER A 251GLU A 253GLU A 254 | 1.78A | 18.90 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1NT6_A_DVAA6_0 (GRAMICIDIN C) | L-Valine | 3 / 3 | ALA A 199VAL A 247TRP A 217 | 1.39A | 4.12 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3UJ7_B_SAMB302_1 (PHOSPHOETHANOLAMINEN-METHYLTRANSFERASE) | S-Adenosylmethionine | 4 / 5 | TYR B 66SER B 28ASP A 37ILE A 23 | 1.46A | 17.18 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4Z4C_A_IPHA905_0 (PROTEIN ARGONAUTE-2) | Phenol | 4 / 5 | PHE A 33PRO A 47VAL A 34ALA A 49 | 1.52A | 15.37 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4B3O_A_EFZA1557_1 (REVERSETRANSCRIPTASE/RIBONUCLEASE H) | Efavirenz | 5 / 9 | LEU A 95TYR A 118TYR A 123LEU C 10TYR A 74 | 1.66A | 19.78 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ZVG_A_SAMA401_0 (389AA LONGHYPOTHETICALNUCLEOLAR PROTEIN) | S-Adenosylmethionine | 5 / 12 | ALA A 49GLY A 175ASP B 53ARG A 35PRO A 47 | 1.68A | 20.26 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4XQE_A_AG2A506_1 (HOMOSPERMIDINESYNTHASE) | Agmatine | 4 / 6 | ARG A 6ASP A 102VAL A 28ASP A 29 | 1.76A | 21.53 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4UIN_H_QI9H1226_0 (FAB 314.3) | Quinine | 5 / 12 | SER B 55GLY A 237ARG A 239PHE A 241LEU A 32 | 1.71A | 18.3420.00 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3K8M_A_ACRA720_1 (ALPHA-AMYLASE, SUSG) | Acarbose | 4 / 7 | GLU A 148TRP A 133LEU C 8ASN A 114 | 1.77A | 16.42 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ACA_C_DXCC1479_0 (TRANSLATIONELONGATION FACTORSELB) | Deoxycholic Acid | 4 / 5 | THR C 3ILE A 66GLU A 63PHE A 22 | 1.52A | 2.00 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1XOT_B_VDNB102_1 (CAMP-SPECIFIC3',5'-CYCLICPHOSPHODIESTERASE 4B) | Vardenafil | 5 / 12 | HIS B 84MET A 12ILE B 35SER B 57SER B 52 | 1.60A | 14.71 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5IGZ_A_SPRA404_2 (MACROLIDE2'-PHOSPHOTRANSFERASE II) | Spiramycin | 5 / 9 | LEU A 179HIS A 3ILE A 52GLU A 53GLU A 173 | 1.42A | 21.50 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1GTI_F_CCSF47_0 (GLUTATHIONES-TRANSFERASE) | Carbocisteine | 4 / 5 | LEU A 160GLY A 162LYS C 1TYR A 159 | 1.11A | 21.05 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3Q5R_A_KANA2002_1 (MULTIDRUG-EFFLUXTRANSPORTER 1REGULATOR) | Kanamycin | 5 / 11 | VAL A 34TYR A 59ILE A 23GLU C 2ILE A 66 | 1.79A | 23.35 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2QL8_A_BEZA143_0 (PUTATIVE REDOXPROTEIN) | Benzoic Acid | 4 / 7 | THR A 94ALA A 11PRO B 32ARG A 21 | 1.37A | 17.34 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6H7U_A_FVTA501_0 (PEPTIDE ABCTRANSPORTER PERMEASE) | Aminolevulinic acid | 4 / 6 | VAL A 28ASN A 174ILE A 52GLU A 55 | 1.61A | 19.67 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2TSR_C_D16C509_1 (THYMIDYLATE SYNTHASE) | Raltitrexed | 5 / 10 | PHE A 33GLU A 55ILE A 52ASP A 177GLY A 175 | 1.72A | 23.26 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1A4G_B_ZMRB466_2 (NEURAMINIDASE) | Zanamivir | 3 / 3 | ASP A 39ARG A 21ILE A 23 | 1.49A | 21.71 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2HDN_F_TACF3888_1 (ELONGATION FACTOREF-TU) | Tetracycline | 4 / 7 | THR A 94SER A 92PRO B 32LEU B 64 | 1.34A | 9.8720.47 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5H2U_A_1N1A501_1 (PROTEIN-TYROSINEKINASE 6) | Dasatinib | 6 / 12 | ALA A 205LEU A 270THR A 187GLY A 265GLU A 264LEU A 266 | 1.59A | 23.96 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1GAH_A_ACRA497_2 (GLUCOAMYLASE-471) | Acarbose | 4 / 6 | ALA A 150ARG A 97LEU A 147TRP A 133 | 1.62A | 20.25 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1TZ8_C_DESC129_1 (TRANSTHYRETIN) | Diethylstilbestrol | 4 / 6 | LEU C 5ALA C 6LEU C 8SER A 77 | 1.37A | 5.51 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4QB9_E_PARE500_1 (ENHANCEDINTRACELLULARSURVIVAL PROTEIN) | Paromomycin | 5 / 12 | LEU A 32THR A 31ASP A 30ASP A 29TYR A 171 | 1.69A | 21.33 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2VN0_A_TDZA501_1 (CYTOCHROME P450 2C8) | Troglitazone | 5 / 12 | THR A 258LEU A 215VAL A 189VAL A 247GLU A 229 | 1.13A | 19.54 | None | ||
| Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5J6H_A_NCAA402_0 (H-2 CLASS IHISTOCOMPATIBILITYANTIGEN, Q10 ALPHACHAIN) | Nicotinamide | 3 / 3 | PRO A 47ARG A 48GLU A 53 | 0.36A | 75.55 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1N13_J_AG2J7013_1 (PYRUVOYL-DEPENDENTARGININEDECARBOXYLASE BETACHAINPYRUVOYL-DEPENDENTARGININEDECARBOXYLASE ALPHACHAIN) | Agmatine | 4 / 7 | LEU A 110ASP A 102GLY A 100ARG A 6 | 1.52A | 16.2317.78 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ROX_B_T44B128_1 (TRANSTHYRETIN) | Levothyroxine | 4 / 6 | LEU A 160GLU A 163ALA A 158LEU A 130 | 1.26A | 19.29 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1MXD_A_ACRA734_1 (ALPHA AMYLASE) | Acarbose | 4 / 6 | ASN A 174TRP A 51TYR A 171TRP A 60 | 1.70A | 22.17 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1RS7_B_MTLB871_0 (NITRIC-OXIDESYNTHASE, BRAIN) | Mannitol | 4 / 8 | GLN A 96PHE A 8ASN A 114TRP B 60 | 1.50A | 20.70 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ROD_D_NCAD302_0 (NICOTINAMIDEN-METHYLTRANSFERASE) | Nicotinamide | 4 / 7 | LEU C 10ALA A 139TYR A 123TYR A 116 | 1.51A | 3.19 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1KI7_B_ID2B2_0 (THYMIDINE KINASE) | Idoxuridine | 5 / 12 | GLU A 163ILE A 66TYR A 99ARG A 62GLU A 63 | 1.60A | 24.78 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3RV5_C_DXCC92_0 (TROPONIN C, SLOWSKELETAL AND CARDIACMUSCLES) | Deoxycholic Acid | 4 / 4 | VAL A 25PHE B 56PHE B 30VAL B 27 | 1.78A | 12.73 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3V5W_A_8PRA701_1 (G-PROTEIN COUPLEDRECEPTOR KINASE 2) | Paroxetine | 5 / 12 | ILE B 7GLY B 29VAL B 27LEU B 54LEU B 87 | 1.39A | 9.49 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4D39_A_MTLA870_0 (NITRIC OXIDESYNTHASE,ENDOTHELIAL) | Mannitol | 4 / 8 | ARG A 170ASN A 174GLU A 53ILE A 52 | 1.45A | 21.63 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3BGD_B_PM6B302_1 (THIOPURINES-METHYLTRANSFERASE) | Mercaptopurine | 4 / 7 | GLN A 155LEU A 156LEU C 8LEU C 5 | 1.12A | 21.48 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1IE9_A_VDXA500_1 (VITAMIN D3 RECEPTOR) | Calcitriol | 5 / 12 | LEU A 147LEU C 10SER A 77VAL A 152LEU C 5 | 1.59A | 21.84 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4XYZ_A_ACTA103_0 (POLYUBIQUITIN-C) | Acetic acid | 4 / 4 | LEU B 87ILE B 35HIS B 84VAL B 82 | 1.48A | 26.21 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3UR0_B_SVRB516_1 (RNA-DEPENDENT RNAPOLYMERASE) | Suramin | 4 / 7 | PRO A 15GLY A 18ASP B 34ARG A 21 | 1.34A | 20.15 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1VM1_A_TAZA504_1 (BETA-LACTAMASE SHV-1) | Tazobactam | 3 / 3 | ASP A 220TYR A 257GLU A 253 | 1.75A | 22.88 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4KS8_A_B49A701_1 (SERINE/THREONINE-PROTEIN KINASE PAK 6) | Sunitinib | 5 / 10 | ILE A 52ALA A 49GLY A 175LEU A 179ASP A 29 | 1.49A | 24.26 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1KIA_C_ACTC2294_0 (GLYCINEN-METHYLTRANSFERASE) | Acetic acid | 4 / 7 | ASN A 70TYR A 99TYR A 116TYR A 74 | 1.55A | 22.99 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4K36_A_SAMA504_0 (ANAEROBICSULFATASE-MATURATINGENZYME) | S-Adenosylmethionine | 5 / 12 | ASN B 24LEU B 64VAL B 37ILE B 35LEU B 87 | 1.60A | 13.61 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6HCX_A_ZMRA519_1 (NEURAMINIDASE) | Zanamivir | 3 / 3 | TRP A 60ILE A 52GLU C 2 | 1.38A | 20.95 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4MJ8_A_SPMA202_1 (SPERMIDINEN1-ACETYLTRANSFERASE) | Spermine | 4 / 8 | GLU A 163ILE A 66GLU C 2GLU A 63 | 1.10A | 20.58 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5YJ0_G_EF2G501_1 (PROTEIN CEREBLON) | Thalidomide | 4 / 7 | HIS A 113TRP B 60PHE B 56THR A 134 | 1.75A | 13.55 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4UW0_A_SAMA1506_0 (WBDD) | S-Adenosylmethionine | 5 / 12 | ALA A 245ILE A 213GLU A 212LEU A 272VAL A 261 | 1.47A | 18.97 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3RAV_A_RAVA183_1 (FERRITIN LIGHT CHAIN) | Pentobarbital | 4 / 6 | LEU C 10TYR A 118ALA A 139LEU A 95 | 1.44A | 17.07 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ERS_A_ACTA803_0 (GEPHYRIN) | Acetic acid | 3 / 3 | THR A 73ALA C 6ASN A 70 | 1.07A | 21.53 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4WA5_A_ZMRA501_1 (NEURAMINIDASE) | Zanamivir | 5 / 12 | GLU A 55ALA C 4GLU A 163TYR A 7TYR A 171 | 1.54A | 19.75 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1Q23_B_FUAB703_2 (CHLORAMPHENICOLACETYLTRANSFERASE) | Fusidic Acid | 3 / 3 | VAL A 249ALA A 199HIS A 192 | 1.58A | 18.71 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ARM_A_OINA401_1 (PHOSPHOLIPASE A2VRV-PL-VIIIA) | Hyoscyamine | 4 / 7 | GLY A 26HIS A 9TYR A 99LYS C 1 | 1.40A | 16.36 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1IG3_B_VIBB501_1 (THIAMINPYROPHOSPHOKINASE) | Thiamine | 4 / 7 | GLN A 65LEU C 8SER A 67ASN A 70 | 1.42A | 21.19 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3J6G_B_TA1B502_1 (TUBULIN BETA CHAIN) | Paclitaxel | 5 / 10 | VAL B 82HIS B 84THR A 94GLN A 96LEU B 54 | 1.64A | 12.68 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6CNJ_D_NCTD402_1 (NEURONALACETYLCHOLINERECEPTOR SUBUNITALPHA-4NEURONALACETYLCHOLINERECEPTOR SUBUNITBETA-2) | Nicotine | 4 / 8 | THR A 233TYR B 10TRP A 204LEU A 206 | 1.64A | 21.6520.10 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1T9W_A_NFNA6001_1 (ACRIFLAVINERESISTANCE PROTEIN B) | Nafcillin | 3 / 3 | SER A 92GLY A 91ARG A 17 | 1.48A | 13.61 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2XZ5_B_ACHB1211_0 (SOLUBLEACETYLCHOLINERECEPTOR) | Acetylcholine | 4 / 8 | TYR A 85TYR A 123GLN A 96SER A 77 | 1.46A | 20.63 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3CAJ_A_EZLA265_1 (CARBONIC ANHYDRASE 2) | Ethoxzolamide | 5 / 10 | HIS A 192VAL A 189LEU A 201THR A 200TRP A 274 | 1.65A | 21.02 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5M0O_A_EPAA502_1 (TERMINALOLEFIN-FORMING FATTYACID DECARBOXYLASE) | Icosapent | 5 / 10 | LEU B 54PHE B 62ARG A 21ALA A 11PRO B 5 | 1.70A | 12.80 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4XK8_A_PQNA844_1 (PHOTOSYSTEM I P700CHLOROPHYLL AAPOPROTEIN A1) | Phylloquinone | 4 / 7 | MET A 5ARG A 239ALA A 49LEU A 32 | 1.41A | 15.29 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4FZV_A_SAMA401_1 (PUTATIVEMETHYLTRANSFERASENSUN4) | S-Adenosylmethionine | 3 / 3 | ASP A 183ARG A 181ASP A 238 | 1.55A | 21.14 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2F6D_A_ACRA995_1 (GLUCOAMYLASE GLU1) | Acarbose | 5 / 12 | TYR A 7GLY A 162GLU A 163ARG A 62GLU A 63 | 1.67A | 18.74 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3RXH_A_HSMA7_1 (CATIONIC TRYPSIN) | Histamine | 4 / 5 | ASP A 102SER A 4VAL A 28GLY A 100 | 1.75A | 20.68 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1SN5_C_T3C601_2 (TRANSTHYRETIN) | Liothyronine | 4 / 8 | LEU A 160GLU A 163ALA A 158LEU A 130 | 1.19A | 19.46 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1XIU_B_9CRB202_1 (RXR-LIKE PROTEIN) | Alitretinoin | 5 / 12 | ALA A 136ALA A 140GLN A 141HIS A 93LEU A 81 | 1.35A | 22.07 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5IKT_B_TLFB601_0 (PROSTAGLANDIN G/HSYNTHASE 2) | Tolfenamic Acid | 5 / 12 | VAL A 28VAL A 103LEU A 110GLY A 1LEU A 172 | 1.42A | 18.81 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1FML_B_RTLB501_0 (RETINOL DEHYDRATASE) | Vitamin A | 6 / 12 | TYR A 84LEU A 81SER A 77LEU A 147TYR A 116ILE A 124 | 1.69A | 19.23 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4RET_C_DGXC2005_1 (SODIUM/POTASSIUM-TRANSPORTING ATPASESUBUNIT ALPHA-1) | Digoxin | 5 / 12 | GLN A 115LEU A 130GLY A 100GLU A 161LEU C 8 | 1.54A | 13.31 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2V57_A_PRLA1188_0 (TETR FAMILYTRANSCRIPTIONALREPRESSOR LFRR) | Proflavine | 4 / 8 | HIS A 9SER A 67ASN A 70ILE A 66 | 1.16A | 20.80 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4FP9_D_SAMD401_1 (METHYLTRANSFERASENSUN4) | S-Adenosylmethionine | 3 / 3 | ASP A 183ARG A 181ASP A 238 | 1.74A | 21.35 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4DRJ_A_RAPA201_2 (PEPTIDYL-PROLYLCIS-TRANS ISOMERASEFKBP4SERINE/THREONINE-PROTEIN KINASE MTOR) | Sirolimus | 4 / 8 | LEU C 10THR A 138ASP A 137TYR A 118 | 1.28A | 14.29 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2QL8_B_BEZB143_0 (PUTATIVE REDOXPROTEIN) | Benzoic Acid | 4 / 6 | ARG A 21THR A 94ALA A 11PRO B 32 | 1.36A | 17.34 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ZM8_A_ACAA511_1 (6-AMINOHEXANOATE-DIMER HYDROLASE) | Aminocaproic Acid | 4 / 8 | TYR A 123TYR A 84TYR A 118HIS A 93 | 1.02A | 24.74 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3JZ0_B_CLYB900_1 (LINCOSAMIDENUCLEOTIDYLTRANSFERASE) | Clindamycin | 4 / 8 | TYR B 63GLU A 232PHE A 8ILE A 23 | 1.46A | 15.14 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2YFB_B_ACTB501_0 (METHYL-ACCEPTINGCHEMOTAXISTRANSDUCER) | Acetic acid | 4 / 6 | ARG A 48VAL A 25ARG A 35ILE A 23 | 1.30A | 23.05 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5HUA_A_FK5A201_1 (FK506-BINDINGPROTEIN 1) | Tacrolimus | 5 / 11 | PHE A 8VAL A 25ILE A 23LEU A 95PHE B 62 | 1.55A | 19.62 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5IGJ_A_CTYA402_2 (MACROLIDE2'-PHOSPHOTRANSFERASE) | Clarithromycin | 4 / 5 | PRO A 43HIS A 9LEU B 64PHE A 33 | 1.30A | 20.62 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5YNM_A_SAMA401_0 (NSP16 PROTEIN) | S-Adenosylmethionine | 5 / 12 | GLY A 237GLY A 207LEU A 32ASP B 53ASP A 238 | 1.67A | 20.24 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4A7U_A_ALEA1001_1 (SUPEROXIDE DISMUTASE[CU-ZN]) | Epinephrine | 4 / 6 | GLU A 55PRO A 57TRP A 167GLU A 58 | 1.45A | 19.77 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4MWZ_A_SAMA301_0 (PHOSPHOETHANOLAMINEN-METHYLTRANSFERASE,PUTATIVE) | S-Adenosylmethionine | 5 / 12 | TYR A 118ILE B 1ARG A 14SER A 92HIS A 93 | 1.45A | 22.61 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1FBY_B_9CRB1500_1 (RETINOIC ACIDRECEPTOR RXR-ALPHA) | Alitretinoin | 5 / 12 | ALA A 140ALA A 139GLN A 141ALA A 135HIS A 93 | 1.50A | 20.70 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3K9F_H_LFXH0_1 (DNA TOPOISOMERASE 4SUBUNIT ADNA TOPOISOMERASE 4SUBUNIT B) | Levofloxacin | 4 / 6 | SER B 33ARG A 82GLY A 91GLU A 89 | 1.37A | 13.2015.89 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2F8D_A_BEZA1002_0 (HTH-TYPETRANSCRIPTIONALREGULATOR BENM) | Benzoic Acid | 5 / 10 | LEU C 8LEU C 9LEU A 95ARG A 97TYR A 116 | 1.49A | 4.79 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4MA8_C_Z80C301_1 (MAJOR PRION PROTEIN) | Chlorpromazine | 4 / 5 | LEU A 266GLY A 265ILE A 213GLN A 262 | 1.25A | 17.95 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2BXF_A_DZPA2001_1 (SERUM ALBUMIN) | Diazepam | 5 / 12 | LEU A 81TYR A 123LEU C 10GLU A 148LEU A 147 | 1.64A | 19.35 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2A3C_A_PNXA1435_1 (CHITINASE) | Pentoxifylline | 4 / 6 | TYR A 27GLY B 29PHE B 62SER B 61 | 1.41A | 20.14 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5N0O_A_SAMA501_1 (PEPTIDEN-METHYLTRANSFERASE) | S-Adenosylmethionine | 3 / 3 | ALA A 211GLN A 242THR A 233 | 1.22A | 21.27 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2E7F_A_C2FA3000_0 (5-METHYLTETRAHYDROFOLATE CORRINOID/IRONSULFUR PROTEINMETHYLTRANSFERASE) | Levomefolic acid | 5 / 12 | GLU A 63PHE A 33ASN A 70LEU C 8ILE A 66 | 1.48A | 21.64 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3K2H_A_LYAA514_1 (DIHYDROFOLATEREDUCTASE/THYMIDYLATE SYNTHASE) | Pemetrexed | 5 / 12 | LEU C 8ILE A 124SER A 143LEU A 147LEU A 156 | 1.27A | 3.56 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6A5Z_L_9CRL501_0 (RETINOIC ACIDRECEPTOR RXR-ALPHA) | Alitretinoin | 5 / 12 | ALA A 140ALA A 139GLN A 141ALA A 135ILE B 1 | 1.07A | 20.42 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1NNC_A_ZMRA479_1 (NEURAMINIDASE N9) | Zanamivir | 5 / 12 | ARG A 97ARG A 62GLU C 2GLU A 163TYR A 99 | 1.77A | 20.95 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3S3N_A_DLUA398_1 (PFV INTEGRASE) | Dolutegravir | 4 / 8 | GLY A 26PRO A 47GLU A 46ARG A 239 | 1.50A | 19.80 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4DF3_A_SAMA301_1 (FIBRILLARIN-LIKERRNA/TRNA2'-O-METHYLTRANSFERASE) | S-Adenosylmethionine | 3 / 3 | TYR A 209THR A 31GLU A 180 | 1.61A | 21.55 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4TZU_B_Y70B505_1 (PROTEIN CEREBLON) | Pomalidomide | 4 / 7 | HIS A 113TRP B 60PHE B 56THR A 134 | 1.68A | 13.24 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4EQ4_A_SALA601_1 (4-SUBSTITUTEDBENZOATES-GLUTAMATELIGASE GH3.12) | Salicylic acid | 4 / 7 | LEU A 81TYR A 123ILE A 142GLY A 83 | 1.35A | 19.29 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3QXY_A_SAMA6734_0 (N-LYSINEMETHYLTRANSFERASESETD6) | S-Adenosylmethionine | 5 / 12 | GLY A 237ALA B 15ASN B 24LEU B 39PHE B 70 | 1.62A | 19.61 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5BTG_F_LFXF101_1 (DNA GYRASE SUBUNIT ADNA GYRASE SUBUNIT BDNA SUBSTRATE 24-MERTTACGTGCATAGTCATTCATGACC) | Levofloxacin | 4 / 7 | ALA A 11ASP B 53ARG A 35GLU A 46 | 1.24A | 20.5822.57 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3TPX_E_ACTE204_0 (E3 UBIQUITIN-PROTEINLIGASE MDM2) | Acetic acid | 3 / 3 | LYS A 268PRO A 269LEU A 270 | 1.29A | 15.12 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1JLF_A_NVPA999_1 (HIV-1 RT A-CHAINHIV-1 RT B-CHAIN) | Nevirapine | 4 / 8 | LEU A 172VAL A 103GLY A 104GLU A 180 | 1.18A | 19.7820.54 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4MMA_A_CXXA603_1 (TRANSPORTER) | Clomipramine | 5 / 11 | PRO A 210ALA A 182PHE A 208GLY A 265THR A 240 | 1.64A | 20.08 | None |