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| PDB ID: 2v6n Macromolecule: REPLICASE POLYPROTEIN 1AB Source Organism: SARSr-CoV Gene names: - UniProt ID: P0C6X7 |
SIMILAR PATTERN OF AMINO ACIDS MAPPED TO PDBID '2v6n'
1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.| DrReposER ID / Desc. | Drug | Res. Matches |
View | Interface | RMSD | Seq. Identity (%) |
HETATM | Dock | |
|---|---|---|---|---|---|---|---|---|---|
 Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5MFX_A_ACTA701_0 (GENOME POLYPROTEIN) | Acetic acid | 4 / 5 | THR A 45HIS A 41ALA A 46ASP A 48 | 1.53A | 21.98 | NoneXP1 A2307 (-3.4A)NoneNone | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ZM8_A_ACAA512_1 (6-AMINOHEXANOATE-DIMER HYDROLASE) | Aminocaproic Acid | 5 / 10 | ALA A 116TYR A 118SER A 144HIS A 163GLY A 124 | 1.44A | 22.46 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2XKW_B_P1BB1475_2 (PEROXISOMEPROLIFERATOR-ACTIVATED RECEPTOR GAMMA) | Pioglitazone | 4 / 6 | LEU A 86ARG A 88ILE A 152LEU A 115 | 1.27A | 22.57 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4KCN_B_MTLB806_0 (NITRIC OXIDESYNTHASE, BRAIN) | Mannitol | 4 / 7 | SER A 113GLN A 110PHE A 112ASP A 295 | 1.61A | 21.10 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3FW3_B_ETSB303_1 (CARBONIC ANHYDRASE 4) | Dorzolamide | 5 / 12 | ASN A 231HIS A 246VAL A 247LEU A 205THR A 201 | 1.44A | 19.29 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2IEO_A_017A402_2 (PROTEASE) | Darunavir | 6 / 12 | LEU A 67GLY A 71ALA A 70VAL A 36GLY A 120VAL A 68 | 1.70A | 14.29 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2BTE_A_LEUA1894_0 (AMINOACYL-TRNASYNTHETASE) | L-Leucine | 4 / 8 | SER A 144TYR A 161HIS A 172HIS A 163 | 1.30A | 15.26 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5HIK_A_SAMA301_0 (GLYCINE SARCOSINEN-METHYLTRANSFERASE) | S-Adenosylmethionine | 5 / 12 | GLY A 146GLY A 174MET A 162GLY A 143HIS A 41 | 1.42A | 20.31 | NoneNoneNoneNoneXP1 A2307 (-3.4A) | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3NU9_A_478A401_2 (PROTEASE) | Amprenavir | 6 / 10 | LEU A 67GLY A 71ALA A 70VAL A 36GLY A 120VAL A 68 | 1.66A | 14.29 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3N66_B_MTLB870_0 (NITRIC OXIDESYNTHASE) | Mannitol | 4 / 8 | SER A 113GLN A 110PHE A 112ASP A 295 | 1.61A | 21.10 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3HM1_A_J3ZA2_1 (ESTROGEN RECEPTOR) | Estrone | 5 / 12 | MET A 17LEU A 30LEU A 86LEU A 177LEU A 27 | 1.47A | 20.94 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2BXG_A_IBPA2001_1 (SERUM ALBUMIN) | Ibuprofen | 5 / 11 | LEU A 86TYR A 101VAL A 148GLY A 149LEU A 30 | 1.49A | 18.70 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1QZR_B_CDXB901_1 (DNA TOPOISOMERASE II) | Dexrazoxane | 4 / 7 | HIS A 41THR A 25ASN A 119GLN A 19 | 1.25A | 20.70 | XP1 A2307 (-3.4A)NoneNoneNone | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4CSV_A_STIA1265_1 (SRC-ABL TYROSINEKINASE ANCESTOR) | Imatinib | 5 / 12 | VAL A 296ALA A 210GLU A 288ILE A 286ASP A 289 | 1.43A | 19.88 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2BM9_D_SAMD301_0 (CEPHALOSPORINHYDROXYLASE CMCI) | S-Adenosylmethionine | 5 / 12 | LEU A 177LEU A 86GLY A 29TYR A 37CYH A 117 | 1.34A | 23.99 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5K7U_A_SAMA601_0 (N6-ADENOSINE-METHYLTRANSFERASE 70 KDASUBUNIT) | S-Adenosylmethionine | 5 / 12 | ASP A 216ILE A 281GLU A 288ARG A 4GLY A 283 | 1.75A | 20.37 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2V0G_A_LEUA1887_0 (AMINOACYL-TRNASYNTHETASE) | L-Leucine | 4 / 8 | SER A 144TYR A 161HIS A 172HIS A 163 | 1.39A | 15.26 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5KPC_A_SAMA401_1 (PAVINEN-METHYLTRANSFERASE) | S-Adenosylmethionine | 4 / 5 | PHE A 112SER A 113ASN A 203GLN A 110 | 1.30A | 22.30 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6DYO_A_LDPA901_0 (EBONY) | Dopamine | 4 / 5 | VAL A 20LEU A 27HIS A 164THR A 25 | 1.56A | 22.65 | NoneNoneXP1 A2307 (-4.6A)None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5NN6_A_MIGA1013_1 (LYSOSOMALALPHA-GLUCOSIDASE) | Miglitol | 5 / 12 | LEU A 57ILE A 43MET A 82ASP A 187HIS A 41 | 1.77A | 15.80 | NoneNoneNoneNoneXP1 A2307 (-3.4A) | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1GSE_A_EAAA224_1 (GLUTATHIONETRANSFERASE) | Etacrynic acid | 5 / 12 | ARG A 4GLY A 2LEU A 282VAL A 296MET A 6 | 1.48A | 20.78 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2BYT_A_LEUA1301_0 (LEUCYL-TRNASYNTHETASE) | L-Leucine | 4 / 7 | TYR A 126TYR A 161HIS A 172HIS A 163 | 1.75A | 15.26 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2XFS_B_J01B600_1 (ORF12) | Clavulanate | 5 / 11 | LYS A 137ALA A 193THR A 169ALA A 194GLY A 195 | 1.59A | 20.55 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5C0O_H_SAMH301_0 (TRNA(ADENINE(58)-N(1))-METHYLTRANSFERASETRMI) | S-Adenosylmethionine | 5 / 12 | ALA A 116GLY A 149SER A 147GLY A 146LEU A 30 | 1.25A | 21.54 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4IJI_F_BEZF501_0 (GLUTATHIONES-TRANSFERASE-LIKEPROTEIN YIBF) | Benzoic Acid | 4 / 8 | ASN A 214SER A 1LEU A 282ARG A 4 | 1.51A | 19.87 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6AUU_B_MTLB805_0 (NITRIC OXIDESYNTHASE, BRAIN) | Mannitol | 4 / 8 | SER A 113GLN A 110PHE A 112ASP A 295 | 1.59A | 21.10 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4OT2_A_NPSA601_1 (SERUM ALBUMIN) | Naproxen | 5 / 12 | LEU A 86TYR A 101VAL A 148GLY A 149LEU A 30 | 1.50A | 17.24 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4MA7_A_P2ZA301_1 (MAJOR PRION PROTEIN) | Promazine | 4 / 8 | VAL A 104TYR A 161ILE A 136THR A 292 | 1.14A | 17.28 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4PFJ_A_ADNA502_2 (ADENOSYLHOMOCYSTEINASE) | Adenosine | 4 / 7 | THR A 175HIS A 41LEU A 27ASN A 28 | 1.47A | 20.09 | NoneXP1 A2307 (-3.4A)NoneNone | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2JT9_A_ACAA7_1 (5-MERIMMUNOSUPPRESSORYPEPTIDE FROMCYCLOLINOPEPTIDE XMODIFIED 16-MERIMMUNOSUPPRESSORYPEPTIDE FROMHOMEOTIC PROTEINANTENNAPEDIA) | Aminocaproic Acid | 4 / 5 | PRO A 52LEU A 57LEU A 58ARG A 188 | 1.41A | 10.004.22 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2QWX_A_ML1A233_1 (RIBOSYLDIHYDRONICOTINAMIDE DEHYDROGENASE[QUINONE]) | Melatonin | 4 / 8 | ILE A 136PHE A 140GLY A 149ILE A 106 | 0.99A | 22.26 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5VUO_B_MTLB805_0 (NITRIC OXIDESYNTHASE, BRAIN) | Mannitol | 4 / 8 | SER A 113GLN A 110PHE A 112ASP A 295 | 1.64A | 21.10 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5VUN_A_MTLA805_0 (NITRIC OXIDESYNTHASE, BRAIN) | Mannitol | 4 / 8 | SER A 113GLN A 110PHE A 112ASP A 295 | 1.59A | 21.10 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4QOG_A_ML1A302_1 (RIBOSYLDIHYDRONICOTINAMIDE DEHYDROGENASE[QUINONE]) | Melatonin | 4 / 8 | ILE A 136PHE A 140GLY A 149ILE A 106 | 1.10A | 22.26 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1FBY_A_9CRA500_1 (RETINOIC ACIDRECEPTOR RXR-ALPHA) | Alitretinoin | 5 / 12 | ILE A 136CYH A 128ALA A 129GLN A 110HIS A 163 | 1.53A | 22.12 | None |