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| PDB ID: 1xak Macromolecule: ORF7A ACCESSORY PROTEIN Source Organism: SARSr-CoV Gene names: - UniProt ID: P59635 |
SIMILAR PATTERN OF AMINO ACIDS MAPPED TO PDBID '1xak'
1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.| DrReposER ID / Desc. | Drug | Res. Matches |
View | Interface | RMSD | Seq. Identity (%) |
HETATM | Dock | |
|---|---|---|---|---|---|---|---|---|---|
 Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1GTN_E_TRPE81_0 (TRP RNA-BINDINGATTENUATION PROTEIN) | L-Tryptophan | 4 / 6 | SER A 29GLY A 11THR A 46THR A 44 | 1.36A | 22.35 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3LTW_A_HLZA300_1 (ARYLAMINEN-ACETYLTRANSFERASENAT) | Hydralazine | 4 / 6 | PHE A 39TYR A 25THR A 59PHE A 48 | 1.62A | 18.60 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3I45_A_NIOA500_1 (TWIN-ARGININETRANSLOCATIONPATHWAY SIGNALPROTEIN) | Niacin | 4 / 8 | SER A 29LEU A 41TYR A 25LEU A 16 | 1.40A | 13.19 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1JLB_A_NVPA999_1 (HIV-1 RT A-CHAIN) | Nevirapine | 4 / 8 | LEU A 41TYR A 60GLY A 27LEU A 62 | 1.22A | 9.98 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4Y8W_A_STRA604_1 (CYTOCHROME P45021-HYDROXYLASE) | Progesterone | 5 / 12 | SER A 45VAL A 67GLY A 11VAL A 14LEU A 62 | 1.50A | 9.81 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4MMD_B_29EB603_1 (TRANSPORTER) | Duloxetine | 5 / 12 | ALA A 49TYR A 60PHE A 31SER A 29GLY A 27 | 1.51A | 10.17 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1YA4_B_CTXB2_2 (CES1 PROTEIN) | Tamoxifen | 4 / 4 | LEU A 62PRO A 33ILE A 15LEU A 16 | 1.27A | 9.15 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2W98_A_P1ZA1351_1 (PROSTAGLANDINREDUCTASE 2) | Phenylbutazone | 5 / 10 | TYR A 60PHE A 39TYR A 5VAL A 14LEU A 41 | 1.65A | 12.57 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5HW4_A_SAMA801_0 (RIBOSOMAL RNA SMALLSUBUNITMETHYLTRANSFERASE I) | S-Adenosylmethionine | 5 / 12 | ILE A 15THR A 12ALA A 40PHE A 48LEU A 34 | 1.57A | 16.00 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1GTN_G_TRPG81_0 (TRP RNA-BINDINGATTENUATION PROTEIN) | L-Tryptophan | 4 / 7 | SER A 29GLY A 11THR A 46THR A 44 | 1.35A | 22.35 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1E7C_A_HLTA4007_1 (SERUM ALBUMIN) | Halothane | 5 / 8 | TYR A 25LEU A 34HIS A 32PHE A 31LEU A 41 | 1.61A | 9.81 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4EM2_A_SALA503_1 (UNCHARACTERIZEDHTH-TYPETRANSCRIPTIONALREGULATOR SAR2349) | Salicylic acid | 4 / 6 | LYS A 38ILE A 15VAL A 14LEU A 41 | 1.46A | 16.57 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4MM4_A_8PRA603_1 (TRANSPORTER) | Paroxetine | 5 / 12 | ALA A 49TYR A 60PHE A 31SER A 29GLY A 27 | 1.47A | 10.00 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3AG1_C_CHDC271_0 (CYTOCHROME C OXIDASEPOLYPEPTIDE 7A1CYTOCHROME C OXIDASESUBUNIT 3) | Cholic Acid | 4 / 6 | LEU A 62GLN A 61LEU A 41PHE A 39 | 1.45A | 14.1823.08 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3GV1_A_BEZA302_0 (DISULFIDEINTERCHANGE PROTEIN) | Benzoic Acid | 4 / 6 | PRO A 19HIS A 4LYS A -1ALA A 51 | 1.78A | 20.98 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4MM4_B_8PRB603_1 (TRANSPORTER) | Paroxetine | 5 / 12 | ALA A 49TYR A 60PHE A 31SER A 29GLY A 27 | 1.50A | 10.00 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6CI6_A_NBOA607_1 (SERUM ALBUMIN) | Nabumetone | 4 / 7 | ASP A 54ALA A 51GLU A 18LEU A 2 | 1.65A | 10.38 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1WRL_E_TFPE212_1 (TROPONIN C, SLOWSKELETAL AND CARDIACMUSCLES) | Trifluoperazine | 4 / 7 | PHE A 48PHE A 31LEU A 34PHE A 50 | 1.40A | 20.20 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2V0M_D_KLND1498_1 (CYTOCHROME P450 3A4) | Ketoconazole | 5 / 11 | ILE A 15PHE A 39ALA A 40ARG A 63LEU A 62 | 1.58A | 12.36 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3LK0_D_Z80D92_1 (PROTEIN S100-B) | Chlorpromazine | 3 / 3 | HIS A 32PHE A 50PHE A 48 | 1.53A | 17.89 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ICR_A_NIOA604_1 (OXYGEN-INSENSITIVENAD(P)HNITROREDUCTASE) | Niacin | 4 / 5 | THR A 24PHE A 50GLU A 26GLY A 27 | 1.67A | 16.50 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5OM3_B_DXTB501_1 (ALPHA-1-ANTICHYMOTRYPSIN) | Doxycycline | 4 / 6 | LEU A 41SER A 29PHE A 48HIS A 47 | 1.44A | 16.7918.75 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2W98_B_P1ZB1356_1 (PROSTAGLANDINREDUCTASE 2) | Phenylbutazone | 5 / 8 | TYR A 60PHE A 39TYR A 5VAL A 14LEU A 41 | 1.71A | 12.57 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6GNE_A_ACRA602_2 (-) | Acarbose | 4 / 6 | TYR A 25HIS A 47TYR A 60GLU A 1 | 1.78A | 9.29 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3PO7_A_ZONA601_1 (AMINE OXIDASE[FLAVIN-CONTAINING]B) | Zonisamide | 4 / 8 | TYR A 60LEU A 41PHE A 39TYR A 25 | 1.29A | 9.54 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5DQY_A_BEZA401_0 (THIOREDOXIN) | Benzoic Acid | 4 / 8 | ILE A 15PHE A 39VAL A 14SER A 29 | 1.34A | 20.39 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1C9S_T_TRPT81_0 (TRP RNA-BINDINGATTENUATION PROTEIN) | L-Tryptophan | 4 / 7 | GLY A 11THR A 46THR A 44SER A 29 | 1.28A | 22.35 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3K2H_A_LYAA514_1 (DIHYDROFOLATEREDUCTASE/THYMIDYLATE SYNTHASE) | Pemetrexed | 5 / 12 | ALA A 64LEU A 62THR A 13LEU A 16LEU A 41 | 1.48A | 11.54 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ZCQ_C_CHDC306_0 (CYTOCHROME C OXIDASESUBUNIT 3CYTOCHROME C OXIDASESUBUNIT 7A1,MITOCHONDRIAL) | Cholic Acid | 4 / 7 | LEU A 62GLN A 61LEU A 41PHE A 39 | 1.38A | 14.1823.08 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2V0M_A_KLNA1500_1 (CYTOCHROME P450 3A4) | Ketoconazole | 5 / 11 | ILE A 15PHE A 39ALA A 40ARG A 63LEU A 62 | 1.46A | 12.36 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1A4L_C_DCFC1353_1 (ADENOSINE DEAMINASE) | Pentostatin | 5 / 12 | HIS A 58PHE A 39PHE A 31ALA A 49HIS A 4 | 1.58A | 12.35 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2WEK_A_DIFA1376_1 (ZINC-BINDING ALCOHOLDEHYDROGENASEDOMAIN-CONTAININGPROTEIN 2) | Diclofenac | 4 / 8 | TYR A 60LEU A 41LEU A 16LYS A 38 | 1.53A | 11.80 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2EIN_P_CHDP1271_0 (CYTOCHROME C OXIDASEPOLYPEPTIDEVIIA-HEARTCYTOCHROME C OXIDASESUBUNIT 3) | Cholic Acid | 4 / 6 | LEU A 62GLN A 61LEU A 41PHE A 39 | 1.57A | 14.1823.08 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3D91_B_REMB350_1 (RENIN) | Remikiren | 5 / 12 | GLY A 11SER A 45THR A 46VAL A 14SER A 29 | 1.74A | 14.29 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ZXW_C_CHDC271_0 (CYTOCHROME C OXIDASEPOLYPEPTIDE 7A1CYTOCHROME C OXIDASESUBUNIT 3) | Cholic Acid | 4 / 7 | LEU A 62GLN A 61LEU A 41PHE A 39 | 1.47A | 14.1823.08 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5VKQ_A_PCFA1808_0 (NO MECHANORECEPTORPOTENTIAL C ISOFORML) | Colfosceril palmitate | 4 / 5 | LEU A 16LYS A 38ALA A 40LEU A 34 | 1.60A | 3.99 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4MM9_A_FVXA603_1 (TRANSPORTER) | Fluvoxamine | 5 / 11 | ALA A 49TYR A 60PHE A 31SER A 29GLY A 27 | 1.63A | 10.00 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2QEU_A_ACTA142_0 (PUTATIVECARBOXYMUCONOLACTONEDECARBOXYLASE) | Acetic acid | 4 / 5 | GLU A 18PRO A 21GLY A 23LYS A 17 | 1.62A | 19.29 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2QBL_A_CAMA517_0 (CYTOCHROME P450-CAM) | Camphor | 4 / 7 | PHE A 39TYR A 25THR A 46VAL A 14 | 1.43A | 11.35 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ZZB_E_ACTE403_0 (PROTON-GATED IONCHANNEL) | Acetic acid | 3 / 3 | ARG A 57TYR A 3GLU A 1 | 1.28A | 14.74 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2QHF_A_ACTA508_0 (CHORISMATE SYNTHASE) | Acetic acid | 4 / 5 | LEU A 34ASP A 36ALA A 35ILE A 15 | 1.62A | 11.45 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1A4L_A_DCFA353_1 (ADENOSINE DEAMINASE) | Pentostatin | 5 / 12 | HIS A 58PHE A 39PHE A 31ALA A 49HIS A 4 | 1.57A | 12.35 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4EJG_B_NCTB501_1 (CYTOCHROME P450 2A13) | Nicotine | 5 / 8 | PHE A 39PHE A 50ALA A 49THR A 59LEU A 62 | 1.65A | 10.83 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3BPX_A_SALA257_1 (TRANSCRIPTIONALREGULATOR) | Salicylic acid | 4 / 8 | SER A 29PHE A 39THR A 13ILE A 15 | 1.32A | 18.92 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2DYS_C_CHDC310_0 (CYTOCHROME C OXIDASEPOLYPEPTIDEVIIA-HEARTCYTOCHROME C OXIDASESUBUNIT 3) | Cholic Acid | 4 / 7 | LEU A 62GLN A 61LEU A 41PHE A 39 | 1.49A | 14.1823.08 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4WG0_A_CHDA103_0 (NUCLEAR RECEPTORCOACTIVATOR 2) | Cholic Acid | 5 / 8 | LEU A 16LEU A 41GLU A 7ALA A 64LEU A 62 | 1.62A | 10.81 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1WRL_F_TFPF211_1 (TROPONIN C, SLOWSKELETAL AND CARDIACMUSCLES) | Trifluoperazine | 4 / 7 | PHE A 48PHE A 31LEU A 34PHE A 50 | 1.31A | 20.20 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ZXW_P_CHDP1271_0 (CYTOCHROME C OXIDASEPOLYPEPTIDE 7A1CYTOCHROME C OXIDASESUBUNIT 3) | Cholic Acid | 4 / 6 | LEU A 62GLN A 61LEU A 41PHE A 39 | 1.57A | 14.1823.08 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2C6N_B_LPRB705_2 (ANGIOTENSIN-CONVERTING ENZYME, SOMATICISOFORM) | Lisinopril | 3 / 3 | ALA A 40THR A 13PHE A 31 | 1.04A | 10.28 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5HFJ_E_SAME301_0 (ADENINE SPECIFIC DNAMETHYLTRANSFERASE(DPNA)) | S-Adenosylmethionine | 5 / 12 | ALA A 49ASP A 54PRO A 21GLY A 23SER A 22 | 1.59A | 15.62 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4AWU_A_4CHA503_0 (OXIDOREDUCTASE,FMN-BINDING) | Parachlorophenol | 4 / 6 | SER A 29PHE A 31PHE A 39PHE A 48 | 1.65A | 13.56 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5CDQ_E_MFXE2101_1 (DNA GYRASE SUBUNIT ADNA GYRASE SUBUNITB,DNA GYRASE SUBUNITB) | Moxifloxacin | 4 / 5 | SER A 22ARG A 57GLY A 55GLU A 1 | 1.66A | 10.5317.65 | None |