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| PDB ID: 1ssk Macromolecule: NUCLEOCAPSID PROTEIN Source Organism: SARSr-CoV Gene names: N UniProt ID: P59595 |
SIMILAR PATTERN OF AMINO ACIDS MAPPED TO PDBID '1ssk'
1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.| DrReposER ID / Desc. | Drug | Res. Matches |
View | Interface | RMSD | Seq. Identity (%) |
HETATM | Dock | |
|---|---|---|---|---|---|---|---|---|---|
 Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5HFJ_B_SAMB301_0 (ADENINE SPECIFIC DNAMETHYLTRANSFERASE(DPNA)) | S-Adenosylmethionine | 5 / 12 | ASP A 59PRO A 120GLN A 61GLY A 92THR A 113 | 1.67A | 17.21 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5VLM_D_CVID301_1 (REGULATORY PROTEINTETR) | Gentian Violet | 4 / 8 | GLN A 61GLY A 57ILE A 124ASP A 122 | 1.23A | 18.88 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3GGU_B_017B201_1 (PROTEASE) | Darunavir | 5 / 12 | GLY A 115ALA A 116ASP A 60GLY A 63PRO A 100 | 1.34A | 23.49 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5VLM_C_CVIC301_1 (REGULATORY PROTEINTETR) | Gentian Violet | 4 / 7 | GLN A 61GLY A 57ILE A 124ASP A 122 | 1.30A | 18.88 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4Q0D_A_MTXA604_1 (BIFUNCTIONALDIHYDROFOLATEREDUCTASE-THYMIDYLATE SYNTHASE) | Methotrexate | 5 / 12 | VAL A 50ALA A 112LEU A 91ILE A 108THR A 113 | 1.57A | 16.08 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2WEK_A_DIFA1373_1 (ZINC-BINDING ALCOHOLDEHYDROGENASEDOMAIN-CONTAININGPROTEIN 2) | Diclofenac | 4 / 8 | PHE A 44VAL A 111PHE A 31ASN A 53 | 1.49A | 19.20 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3PEO_F_CU9F301_2 (SOLUBLEACETYLCHOLINERECEPTOR) | Metocurine | 4 / 6 | THR A 54GLN A 138ILE A 52SER A 56 | 1.68A | 20.09 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4FFW_B_715B801_2 (DIPEPTIDYL PEPTIDASE4) | Sitagliptin | 3 / 3 | ARG A 127TYR A 64ASN A 53 | 1.29A | 12.48 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4PO0_A_NPSA601_1 (SERUM ALBUMIN) | Naproxen | 5 / 12 | VAL A 111PHE A 88LEU A 137VAL A 109LEU A 42 | 1.77A | 11.25 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3NDU_A_ROCA101_1 (PROTEASE) | Saquinavir | 5 / 12 | GLY A 115ALA A 116ASP A 60GLY A 63PRO A 100 | 1.20A | 23.49 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1M17_A_AQ4A999_1 (EPIDERMAL GROWTHFACTOR RECEPTOR) | Erlotinib | 5 / 12 | LEU A 99ALA A 97THR A 93LEU A 91GLY A 102 | 1.48A | 18.69 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1BRP_A_RTLA183_0 (RETINOL BINDINGPROTEIN) | Vitamin A | 5 / 12 | LEU A 137ALA A 33TYR A 65LEU A 145PHE A 31 | 1.71A | 21.43 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3E22_B_LOCB700_1 (TUBULIN ALPHA-1CCHAINTUBULIN BETA-2BCHAIN) | Colchicine | 3 / 3 | SER A 29ALA A 134VAL A 136 | 1.16A | 17.18 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5HS6_A_J3ZA302_1 (17-BETA-HYDROXYSTEROID DEHYDROGENASE 14) | Estrone | 4 / 8 | TYR A 65LEU A 139LEU A 137THR A 54 | 1.41A | 18.82 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1P7L_C_SAMC685_0 (S-ADENOSYLMETHIONINESYNTHETASE) | S-Adenosylmethionine | 4 / 8 | ASP A 60LYS A 121SER A 56ASP A 59 | 1.51A | 17.02 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3TKG_B_ROCB801_2 (PROTEASE) | Saquinavir | 5 / 12 | GLY A 115ALA A 116ASP A 60GLY A 63PRO A 100 | 1.24A | 25.36 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3UCB_B_017B202_1 (PROTEASE) | Darunavir | 4 / 7 | TRP A 110PRO A 100GLY A 92PRO A 95 | 1.79A | 24.83 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1N4F_A_ASRA141_0 (LYSOZYME C) | Arsanilic acid | 4 / 6 | ASP A 60GLY A 57THR A 93PRO A 95 | 1.42A | 21.15 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1RLB_F_REAF177_1 (RETINOL BINDINGPROTEIN) | Tretinoin | 5 / 11 | LEU A 137ALA A 68ALA A 33TYR A 65LEU A 145 | 1.42A | 19.68 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5UL4_A_SAMA803_0 (OXSB PROTEIN) | S-Adenosylmethionine | 5 / 12 | ALA A 116GLY A 92GLY A 57ILE A 124LEU A 137 | 1.73A | 10.60 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1QZZ_A_SAMA635_0 (ACLACINOMYCIN-10-HYDROXYLASE) | S-Adenosylmethionine | 5 / 12 | TYR A 101GLY A 57GLY A 92PRO A 95ASN A 53 | 1.61A | 18.98 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3TKG_B_ROCB801_1 (PROTEASE) | Saquinavir | 5 / 12 | GLY A 115ALA A 116ASP A 60GLY A 63PRO A 100 | 1.19A | 25.36 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1D4F_C_ADNC603_2 (S-ADENOSYLHOMOCYSTEINE HYDROLASE) | Adenosine | 4 / 5 | THR A 143GLU A 152THR A 32LEU A 42 | 1.58A | 18.09 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6FCD_A_ADNA405_0 (S-ADENOSYLMETHIONINESYNTHASE ISOFORMTYPE-2) | Adenosine | 4 / 8 | ASP A 60LYS A 121SER A 56ASP A 59 | 1.51A | 16.80 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ALB_L_TIQL1210_2 (MEDI2452 LIGHT CHAIN) | Ticagrelor | 4 / 8 | SER A 158GLY A 156ALA A 33GLY A 153 | 1.25A | 22.48 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3MBG_A_ACTA207_0 (FAD-LINKEDSULFHYDRYL OXIDASEALR) | Acetic acid | 4 / 7 | LEU A 117ASP A 60THR A 113ALA A 116 | 1.61A | 25.00 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2NMY_A_ROCA401_1 (PROTEASE) | Saquinavir | 5 / 12 | GLY A 115ALA A 116ASP A 60GLY A 63PRO A 100 | 1.21A | 23.49 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3QLG_A_1N1A601_1 (PROTO-ONCOGENETYROSINE-PROTEINKINASE SRC) | Dasatinib | 5 / 12 | LEU A 99ALA A 97THR A 93GLY A 63ALA A 116 | 1.18A | 20.27 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3OU7_B_SAMB300_0 (SAM-DEPENDENTMETHYLTRANSFERASE) | S-Adenosylmethionine | 5 / 12 | ALA A 151GLY A 153LEU A 145ALA A 33HIS A 37 | 1.45A | 20.09 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1TH6_A_OINA401_1 (PHOSPHOLIPASE A2) | Hyoscyamine | 4 / 7 | GLY A 125TRP A 30ASP A 122PRO A 58 | 1.37A | 21.08 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4O0U_A_ADNA501_1 (AURORA KINASE A) | Adenosine | 4 / 6 | VAL A 111LEU A 137THR A 143LEU A 139 | 1.24A | 21.65 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3VQR_A_ACTA1002_0 (PUTATIVEOXIDOREDUCTASE) | Acetic acid | 4 / 6 | ASP A 59GLY A 57ASP A 60THR A 113 | 1.69A | 19.91 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1MUI_B_AB1B100_1 (PROTEASE) | Lopinavir | 5 / 10 | GLY A 115ALA A 116ASP A 60GLY A 63PRO A 100 | 1.32A | 23.49 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4DTZ_A_LDPA501_1 (CYTOCHROME P450 BM3VARIANT 8C8) | Dopamine | 4 / 6 | ALA A 151PRO A 45LEU A 139THR A 144 | 1.51A | 14.91 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5X19_C_CHDC304_0 (CYTOCHROME C OXIDASESUBUNIT 3CYTOCHROME C OXIDASESUBUNIT 7A1,MITOCHONDRIAL) | Cholic Acid | 4 / 5 | LEU A 34PHE A 44LEU A 137PHE A 31 | 1.68A | 18.7016.33 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3OXC_A_ROCA401_3 (PROTEASE) | Saquinavir | 5 / 12 | GLY A 115ALA A 116ASP A 60GLY A 63PRO A 100 | 1.15A | 23.49 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2Z54_A_AB1A200_1 (HIV-1 PROTEASE) | Lopinavir | 5 / 12 | GLY A 115ALA A 116ASP A 60GLY A 63PRO A 100 | 1.32A | 23.49 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5C0O_G_SAMG301_0 (TRNA(ADENINE(58)-N(1))-METHYLTRANSFERASETRMI) | S-Adenosylmethionine | 5 / 12 | THR A 144GLY A 49GLY A 47GLY A 142ALA A 112 | 1.49A | 19.23 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4L1W_A_STRA402_1 (ALDO-KETO REDUCTASEFAMILY 1 MEMBER C2) | Progesterone | 4 / 7 | TYR A 150VAL A 136LEU A 145LEU A 139 | 1.52A | 16.41 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4K8C_A_ADNA401_2 (SUGAR KINASE) | Adenosine | 3 / 3 | SER A 29TYR A 87PRO A 129 | 1.61A | 20.17 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2VDV_F_SAMF1287_0 (TRNA(GUANINE-N(7)-)-METHYLTRANSFERASE) | S-Adenosylmethionine | 5 / 11 | GLY A 47GLU A 114ALA A 116PHE A 44THR A 143 | 1.58A | 20.25 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4PCU_A_SAMA603_0 (CYSTATHIONINEBETA-SYNTHASE) | S-Adenosylmethionine | 4 / 7 | PHE A 88PRO A 140THR A 54ILE A 124 | 1.34A | 16.31 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4O8Z_A_BBIA402_1 (NAD-DEPENDENTPROTEIN DEACETYLASESIRTUIN-3,MITOCHONDRIAL) | Amiodarone | 4 / 5 | PHE A 31PHE A 88LEU A 145PRO A 45 | 1.67A | 22.94 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4KBE_A_ADNA401_2 (PROBABLE SUGARKINASE PROTEIN) | Adenosine | 3 / 3 | SER A 29TYR A 87PRO A 129 | 1.63A | 20.17 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1C6Z_B_ROCB505_1 (PROTEIN (PROTEASE)) | Saquinavir | 5 / 12 | GLY A 115ALA A 116ASP A 60GLY A 63PRO A 100 | 1.22A | 22.82 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4XLI_A_1N1A601_1 (NON-SPECIFICPROTEIN-TYROSINEKINASE) | Dasatinib | 5 / 12 | LEU A 99ALA A 97THR A 93GLY A 63ALA A 116 | 1.19A | 19.62 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4MI4_B_SPMB201_1 (SPERMIDINEN1-ACETYLTRANSFERASE) | Spermine | 4 / 7 | ASN A 104GLU A 41GLU A 106ARG A 67 | 1.77A | 24.39 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5E26_D_PAUD601_0 (PANTOTHENATE KINASE2, MITOCHONDRIAL) | Pantothenic acid | 4 / 8 | VAL A 111TYR A 64ALA A 112GLY A 92 | 1.09A | 17.91 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4QOI_A_ML1A303_1 (RIBOSYLDIHYDRONICOTINAMIDE DEHYDROGENASE[QUINONE]) | Melatonin | 4 / 8 | PHE A 44PHE A 31GLY A 63ASN A 53 | 1.28A | 21.19 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1EQB_A_GLYA1292_0 (SERINEHYDROXYMETHYLTRANSFERASE) | Glycine | 4 / 8 | SER A 3HIS A 6HIS A 5LYS A 1 | 1.58A | 17.20 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2RKG_B_AB1B501_1 (PROTEASE RETROPEPSIN) | Lopinavir | 5 / 12 | GLY A 115ALA A 116ASP A 60GLY A 63PRO A 100 | 1.31A | 25.81 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4LBG_A_ADNA401_2 (PROBABLE SUGARKINASE PROTEIN) | Adenosine | 3 / 3 | SER A 29TYR A 87PRO A 129 | 1.60A | 20.17 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4MMD_B_29EB603_1 (TRANSPORTER) | Duloxetine | 5 / 12 | ASP A 122TYR A 89TYR A 90SER A 56GLY A 57 | 1.37A | 13.98 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4V04_A_0LIA1772_2 (FIBROBLAST GROWTHFACTOR RECEPTOR 1(FMS-RELATEDTYROSINE KINASE 2,PFEIFFER SYNDROME),ISOFORM CRA_B) | Ponatinib | 4 / 8 | TYR A 87LEU A 137ILE A 52PHE A 44 | 1.14A | 20.71 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6FBO_A_ADNA406_0 (S-ADENOSYLMETHIONINESYNTHASE ISOFORMTYPE-2) | Adenosine | 4 / 8 | ASP A 60LYS A 121SER A 56ASP A 59 | 1.55A | 16.67 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ZJ0_D_2FAD500_2 (ADENOSYLHOMOCYSTEINASE) | Fludarabine | 4 / 4 | LEU A 139GLN A 48THR A 143THR A 32 | 1.80A | 15.59 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5X23_A_LSNA504_1 (CYTOCHROME P450 2C9) | Losartan | 4 / 8 | PHE A 31ASN A 53PRO A 146PHE A 44 | 1.36A | 17.12 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2PGZ_D_COCD401_1 (SOLUBLEACETYLCHOLINERECEPTOR) | Cocaine | 4 / 6 | TYR A 89TYR A 65TYR A 90GLN A 61 | 1.77A | 19.92 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1GTI_F_CCSF47_0 (GLUTATHIONES-TRANSFERASE) | Carbocisteine | 4 / 5 | THR A 113LEU A 91GLY A 92TYR A 101 | 1.67A | 19.16 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1RG9_A_SAMA385_0 (S-ADENOSYLMETHIONINESYNTHETASE) | S-Adenosylmethionine | 4 / 8 | ASP A 60LYS A 121SER A 56ASP A 59 | 1.49A | 17.02 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1UWJ_A_BAXA1723_2 (B-RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE) | Sorafenib | 4 / 7 | ILE A 108LEU A 139ILE A 52PHE A 88 | 1.24A | 19.30 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5JGL_B_SAMB301_0 (UBIE/COQ5 FAMILYMETHYLTRANSFERASE,PUTATIVE) | S-Adenosylmethionine | 5 / 12 | TYR A 150THR A 35ALA A 133ALA A 33SER A 154 | 1.49A | 18.43 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5HNZ_B_TA1B902_2 (TUBULIN BETA-2BCHAIN) | Paclitaxel | 3 / 3 | LEU A 139LEU A 145ARG A 155 | 1.01A | 15.28 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1BU5_A_RBFA301_1 (PROTEIN (FLAVODOXIN)) | Riboflavin | 4 / 7 | ASN A 55THR A 93GLY A 57ASP A 59 | 1.46A | 20.12 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6F88_A_STRA502_1 (CYTOCHROME P450CYP260A1) | Progesterone | 4 / 6 | ALA A 151SER A 154THR A 135ASN A 53 | 1.42A | 17.96 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3V4T_D_ACTD502_0 (UDP-N-ACETYLGLUCOSAMINE1-CARBOXYVINYLTRANSFERASE) | Acetic acid | 3 / 3 | GLY A 92THR A 93ASN A 118 | 0.90A | 14.56 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3V4T_H_ACTH502_0 (UDP-N-ACETYLGLUCOSAMINE1-CARBOXYVINYLTRANSFERASE) | Acetic acid | 3 / 3 | SER A 56GLY A 57GLN A 61 | 1.22A | 14.56 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4KTT_A_SAMA405_0 (S-ADENOSYLMETHIONINESYNTHASE ISOFORMTYPE-2) | S-Adenosylmethionine | 4 / 8 | ASP A 60LYS A 121SER A 56ASP A 59 | 1.57A | 16.67 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2OBV_A_SAMA501_0 (S-ADENOSYLMETHIONINESYNTHETASE ISOFORMTYPE-1) | S-Adenosylmethionine | 4 / 8 | ASP A 60LYS A 121SER A 56ASP A 59 | 1.54A | 18.70 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3G5D_B_1N1B1_1 (PROTO-ONCOGENETYROSINE-PROTEINKINASE SRC) | Dasatinib | 5 / 12 | LEU A 99ALA A 97THR A 93GLY A 63ALA A 116 | 1.18A | 20.27 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6MA6_A_MYTA603_0 (CYTOCHROME P450 3A4) | Metyrapone | 4 / 6 | SER A 29ARG A 85ALA A 33THR A 35 | 1.48A | 15.77 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3EL4_A_ROCA100_1 (PROTEASE) | Saquinavir | 5 / 12 | GLY A 115ALA A 116ASP A 60GLY A 63PRO A 100 | 1.34A | 22.82 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4UIN_H_QI9H1226_0 (FAB 314.3) | Quinine | 5 / 12 | TRP A 30THR A 54GLY A 125PHE A 88GLY A 92 | 1.75A | 18.4520.66 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2P02_A_SAMA2_0 (S-ADENOSYLMETHIONINESYNTHETASE ISOFORMTYPE-2) | S-Adenosylmethionine | 4 / 8 | ASP A 60LYS A 121SER A 56ASP A 59 | 1.55A | 16.67 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5VOF_H_RIVH301_1 (COAGULATION FACTOR X) | Rivaroxaban | 5 / 11 | TYR A 65PHE A 31ASP A 60ALA A 116GLY A 92 | 1.43A | 19.05 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2R5Q_D_1UND900_2 (PROTEASE) | Nelfinavir | 5 / 10 | GLY A 115ALA A 116ASP A 60GLY A 63PRO A 100 | 1.29A | 24.16 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3NDT_A_ROCA101_3 (PROTEASE) | Saquinavir | 5 / 12 | GLY A 115ALA A 116ASP A 60GLY A 63PRO A 100 | 1.22A | 23.49 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6MDQ_A_TESA605_0 (SERUM ALBUMIN) | Testosterone | 4 / 8 | GLY A 92LEU A 99LEU A 91GLU A 96 | 1.30A | 13.34 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2DR2_A_TRPA479_0 (TRYPTOPHANYL-TRNASYNTHETASE) | L-Tryptophan | 5 / 11 | TYR A 65GLY A 49GLY A 47THR A 143PHE A 88 | 1.61A | 15.54 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3NDT_D_ROCD100_2 (PROTEASE) | Saquinavir | 5 / 12 | GLY A 115ALA A 116ASP A 60GLY A 63PRO A 100 | 1.25A | 23.49 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1QVT_A_PRLA311_0 (TRANSCRIPTIONALREGULATOR QACR) | Proflavine | 4 / 8 | LEU A 91GLU A 96THR A 126TYR A 64 | 1.39A | 21.11 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5F9Z_B_HFGB703_0 (AMINOACYL-TRNASYNTHETASE) | Halofuginone | 5 / 12 | LEU A 42PHE A 44VAL A 111SER A 29GLY A 125 | 1.67A | 15.18 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1N4F_A_ASRA141_0 (LYSOZYME C) | Arsanilic acid | 4 / 6 | ASP A 60GLY A 92THR A 119PRO A 120 | 1.45A | 21.15 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6E43_A_BEZA502_0 (INDOLEAMINE2,3-DIOXYGENASE 1) | Benzoic Acid | 4 / 6 | PHE A 31VAL A 50LEU A 139LEU A 137 | 1.35A | 23.33 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6AG0_A_ACRA605_0 (ALPHA-AMYLASE) | Acarbose | 4 / 8 | TYR A 90ASP A 60ASP A 59PRO A 120 | 1.38A | 15.90 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4L9Q_A_9TPA601_1 (SERUM ALBUMIN) | Teniposide | 5 / 12 | PRO A 146ALA A 151ILE A 108TYR A 65GLY A 102 | 1.59A | 11.75 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3RUN_A_CCSA165_0 (LYSOZYME) | Carbocisteine | 3 / 3 | ASN A 104ALA A 103LYS A 105 | 1.04A | 22.03 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4PD9_A_ADNA501_1 (NUPC FAMILY PROTEIN) | Adenosine | 5 / 12 | GLY A 47GLN A 48GLU A 114VAL A 111TYR A 65 | 1.49A | 14.18 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1SQF_A_SAMA430_1 (SUN PROTEIN) | S-Adenosylmethionine | 3 / 3 | PRO A 120ASP A 60ASP A 122 | 1.21A | 15.80 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1QVU_A_PRLA196_0 (TRANSCRIPTIONALREGULATOR QACR) | Proflavine | 4 / 6 | LEU A 91GLU A 96THR A 126TYR A 64 | 1.27A | 21.11 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2QD4_B_CHDB927_0 (FERROCHELATASE) | Cholic Acid | 3 / 3 | LEU A 99PRO A 100ARG A 66 | 1.02A | 16.81 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6EQP_A_BUWA601_1 (CHOLINESTERASE) | Ethopropazine | 4 / 8 | GLY A 125SER A 56PHE A 88TYR A 64 | 1.52A | 14.62 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6DJ1_B_AB1B201_0 (HIV-1 PROTEASE) | Lopinavir | 6 / 12 | GLY A 115ALA A 116ASP A 59ASP A 60VAL A 111ILE A 62 | 1.73A | 23.49 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1YA4_B_CTXB2_2 (CES1 PROTEIN) | Tamoxifen | 4 / 4 | LEU A 99PRO A 120ILE A 62LEU A 91 | 1.67A | 16.43 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2AVV_E_MK1E902_1 (POL POLYPROTEIN) | Indinavir | 5 / 12 | GLY A 115ALA A 116ASP A 60GLY A 63PRO A 100 | 1.28A | 22.82 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5O96_D_SAMD501_0 (RIBOSOMAL RNA SMALLSUBUNITMETHYLTRANSFERASE E) | S-Adenosylmethionine | 5 / 10 | ILE A 62GLY A 92GLY A 94LEU A 117ALA A 116 | 1.33A | 19.01 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1RMT_D_ADND1504_1 (CLASS B ACIDPHOSPHATASE) | Adenosine | 4 / 8 | ASP A 122TYR A 89LEU A 91ASP A 60 | 1.45A | 19.91 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ARM_A_OINA401_1 (PHOSPHOLIPASE A2VRV-PL-VIIIA) | Hyoscyamine | 4 / 7 | GLY A 125TRP A 30ASP A 122PRO A 58 | 1.37A | 21.08 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3NDT_D_ROCD100_1 (PROTEASE) | Saquinavir | 5 / 12 | GLY A 115ALA A 116ASP A 60GLY A 63PRO A 100 | 1.20A | 23.49 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3JB3_A_SAMA1102_0 (STRUCTURAL PROTEINVP3) | S-Adenosylmethionine | 5 / 12 | TYR A 87ILE A 124GLY A 125ALA A 134ASN A 132 | 1.46A | 9.17 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3PCQ_B_PQNB842_1 (PHOTOSYSTEM I P700CHLOROPHYLL AAPOPROTEIN A2) | Phylloquinone | 5 / 11 | PHE A 149ARG A 85TRP A 86ALA A 33LEU A 34 | 1.76A | 15.85 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5HBM_A_NVPA601_1 (REVERSETRANSCRIPTASE/RIBONUCLEASE H) | Nevirapine | 5 / 11 | PRO A 95LEU A 91VAL A 50TYR A 90TYR A 101 | 1.65A | 14.77 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3LK0_D_Z80D92_1 (PROTEIN S100-B) | Chlorpromazine | 3 / 3 | HIS A 123PHE A 31PHE A 88 | 1.46A | 19.35 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3N9J_B_EAAB214_1 (GLUTATHIONES-TRANSFERASE P) | Etacrynic acid | 5 / 8 | TYR A 65PHE A 44VAL A 111GLY A 63GLY A 49 | 1.52A | 21.03 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4KAN_A_ADNA401_2 (PROBABLE SUGARKINASE PROTEIN) | Adenosine | 3 / 3 | SER A 29TYR A 87PRO A 129 | 1.61A | 20.17 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1VQ1_A_SAMA301_1 (N5-GLUTAMINEMETHYLTRANSFERASE,HEMK) | S-Adenosylmethionine | 3 / 3 | GLY A 57ASP A 60ASN A 55 | 1.07A | 20.41 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4PWD_A_NVPA901_1 (HIV-1 REVERSETRANSCRIPTASE, P66SUBUNIT) | Nevirapine | 5 / 8 | PRO A 146LEU A 34VAL A 50VAL A 109LEU A 139 | 1.74A | 14.77 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1OHR_A_1UNA201_1 (ASPARTYLPROTEASE) | Nelfinavir | 5 / 11 | GLY A 115ALA A 116ASP A 60GLY A 63PRO A 100 | 1.27A | 23.49 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3FOF_F_MFXF0_1 (DNA TOPOISOMERASE 4SUBUNIT A) | Moxifloxacin | 2 / 3 | GLY A 125SER A 29 | 0.29A | 15.29 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3T3R_D_9PLD501_1 (CYTOCHROME P450 2A6) | Pilocarpine | 5 / 10 | PHE A 88VAL A 50ASN A 53GLY A 57THR A 119 | 1.46A | 17.95 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3QLG_B_1N1B601_1 (PROTO-ONCOGENETYROSINE-PROTEINKINASE SRC) | Dasatinib | 5 / 12 | LEU A 99ALA A 97THR A 93GLY A 63ALA A 116 | 1.21A | 20.27 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2AZX_A_TRPA601_0 (TRYPTOPHANYL-TRNASYNTHETASE) | L-Tryptophan | 5 / 12 | TYR A 65GLY A 49THR A 143GLN A 61PHE A 88 | 1.59A | 12.53 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4A99_C_MIYC391_1 (TETX2 PROTEIN) | Minocycline | 5 / 11 | ASN A 53GLN A 61ASN A 118GLY A 57SER A 56 | 1.58A | 24.64 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3T3R_B_9PLB501_1 (CYTOCHROME P450 2A6) | Pilocarpine | 5 / 9 | PHE A 88VAL A 50ASN A 53GLY A 57THR A 119 | 1.49A | 17.95 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5VM8_B_SAMB301_0 (RIBOSOMAL RNA SMALLSUBUNITMETHYLTRANSFERASE E) | S-Adenosylmethionine | 5 / 10 | LEU A 99ILE A 62LEU A 91THR A 93ALA A 97 | 1.12A | 22.52 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5KI6_A_IPHA901_0 (PROTEIN ARGONAUTE-2) | Phenol | 4 / 5 | LEU A 99TYR A 101LEU A 91TYR A 64 | 1.51A | 11.15 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4FJP_A_NPSA711_1 (LACTOTRANSFERRIN) | Naproxen | 4 / 6 | THR A 54PRO A 58ASN A 55GLY A 92 | 1.27A | 19.10 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4RZV_A_032A801_1 (SERINE/THREONINE-PROTEIN KINASE B-RAF) | Vemurafenib | 5 / 12 | LEU A 91ILE A 124SER A 98GLY A 92GLY A 57 | 1.40A | 19.64 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3WRI_A_CAMA502_0 (CAMPHOR5-MONOOXYGENASE) | Camphor | 4 / 5 | LEU A 91GLY A 63ILE A 108VAL A 109 | 1.35A | 15.17 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3TAJ_A_NBOA700_1 (LACTOTRANSFERRIN) | Nabumetone | 4 / 7 | THR A 54PRO A 58ASN A 55GLY A 92 | 1.21A | 19.10 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3TJ7_A_ACTA604_0 (GBAA_1210 PROTEIN) | Acetic acid | 4 / 6 | GLY A 153VAL A 136SER A 154THR A 32 | 1.66A | 21.13 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5WY0_A_SAMA800_0 (SMALL RNA2'-O-METHYLTRANSFERASE) | S-Adenosylmethionine | 5 / 12 | GLY A 57GLY A 92ASP A 60ASN A 118ILE A 124 | 1.33A | 21.10 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1RL8_A_RITA9001_2 (PROTEASE RETROPEPSIN) | Ritonavir | 5 / 12 | GLY A 115ALA A 116ASP A 60GLY A 63PRO A 100 | 1.25A | 23.49 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2B7Z_B_MK1B200_1 (HIV-1 PROTEASE) | Indinavir | 5 / 12 | GLY A 115ALA A 116ASP A 60GLY A 63PRO A 100 | 1.25A | 22.82 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3K4V_B_ROCB201_3 (HIV-1 PROTEASE) | Saquinavir | 5 / 12 | GLY A 115ALA A 116ASP A 60GLY A 63PRO A 100 | 1.20A | 23.49 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4G2Z_A_ID8A711_1 (LACTOTRANSFERRIN) | Mefenamic acid | 3 / 3 | PRO A 95TYR A 90GLY A 57 | 0.94A | 19.10 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ZVA_A_1N1A513_1 (TYROSINE-PROTEINKINASE LYN) | Dasatinib | 5 / 12 | LEU A 99ALA A 97THR A 93GLY A 63ALA A 116 | 1.14A | 21.22 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6FCB_A_SAMA405_0 (S-ADENOSYLMETHIONINESYNTHASE ISOFORMTYPE-2) | S-Adenosylmethionine | 4 / 8 | ASP A 60LYS A 121SER A 56ASP A 59 | 1.49A | 16.93 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3Q87_B_SAMB300_0 (N6 ADENINE SPECIFICDNA METHYLASE) | S-Adenosylmethionine | 5 / 12 | GLY A 57ILE A 124ASP A 60LEU A 117ASN A 55 | 1.39A | 21.39 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1FB7_A_ROCA100_1 (HIV-1 PROTEASE) | Saquinavir | 5 / 12 | GLY A 115ALA A 116ASP A 60GLY A 63PRO A 100 | 1.27A | 23.49 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6GH9_A_MIXA1003_0 (UBIQUITINCARBOXYL-TERMINALHYDROLASE 15) | Mitoxantrone | 4 / 5 | ASN A 53TYR A 101GLY A 102ASP A 60 | 1.49A | 16.44 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2XYT_H_TC9H1206_2 (SOLUBLEACETYLCHOLINERECEPTOR) | Tubocurarine | 4 / 7 | THR A 54GLN A 138ILE A 52SER A 56 | 1.63A | 19.91 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3OU7_A_SAMA300_0 (SAM-DEPENDENTMETHYLTRANSFERASE) | S-Adenosylmethionine | 5 / 12 | TYR A 65GLY A 63GLY A 57SER A 56ASP A 59 | 1.73A | 20.09 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3EKQ_A_ROCA100_1 (PROTEASE) | Saquinavir | 5 / 12 | GLY A 115ALA A 116ASP A 60GLY A 63PRO A 100 | 1.19A | 22.37 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3EL9_A_DR7A100_1 (PROTEASE) | Atazanavir | 4 / 8 | ARG A 46ALA A 116ASP A 60GLY A 63 | 1.39A | 22.82 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1HXB_A_ROCA100_1 (HIV-1 PROTEASE) | Saquinavir | 5 / 12 | GLY A 115ALA A 116ASP A 60GLY A 63PRO A 100 | 1.13A | 23.49 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1QZF_A_FOLA605_0 (BIFUNCTIONALDIHYDROFOLATEREDUCTASE-THYMIDYLATE SYNTHASE) | Folic Acid | 5 / 12 | VAL A 50ALA A 112LEU A 91ILE A 108THR A 113 | 1.51A | 16.08 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2DRD_A_MIYA2001_1 (ACRB) | Minocycline | 5 / 9 | GLY A 115ASN A 118ILE A 62ALA A 112VAL A 111 | 1.71A | 10.13 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4A6E_A_SAMA1349_0 (HYDROXYINDOLEO-METHYLTRANSFERASE) | S-Adenosylmethionine | 5 / 12 | PHE A 88GLY A 57GLY A 92ILE A 124ALA A 116 | 1.68A | 18.16 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5PHH_A_LDPA414_1 (LYSINE-SPECIFICDEMETHYLASE 4D) | Dopamine | 4 / 6 | GLU A 96ALA A 97LEU A 99TYR A 89 | 1.28A | 19.62 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5KF8_A_GCSA404_1 (PREDICTEDACETYLTRANSFERASE) | Glucosamine | 4 / 8 | PRO A 58GLY A 94PRO A 120ASP A 60 | 1.50A | 18.99 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5O96_E_SAME501_0 (RIBOSOMAL RNA SMALLSUBUNITMETHYLTRANSFERASE E) | S-Adenosylmethionine | 5 / 9 | LEU A 145PRO A 45GLY A 148LEU A 42ARG A 67 | 1.71A | 19.01 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2QHC_B_AB1B9001_2 (PROTEASE RETROPEPSIN) | Lopinavir | 5 / 12 | GLY A 115ALA A 116ASP A 60GLY A 63PRO A 100 | 1.30A | 23.49 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3EL5_B_1UNB201_2 (PROTEASE) | Nelfinavir | 5 / 12 | GLY A 115ALA A 116ASP A 60GLY A 63PRO A 100 | 1.21A | 22.82 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5CXV_A_0HKA501_2 (MUSCARINICACETYLCHOLINERECEPTORM1,ENDOLYSIN,MUSCARINIC ACETYLCHOLINERECEPTOR M1) | Tiotropium | 3 / 3 | THR A 143THR A 144PHE A 149 | 1.22A | 13.64 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1HWI_B_115B1_1 (HMG-COA REDUCTASE) | Fluvastatin | 5 / 9 | ASN A 53LEU A 137ALA A 151LEU A 34LEU A 145 | 1.63A | 14.22 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3T3R_A_9PLA501_1 (CYTOCHROME P450 2A6) | Pilocarpine | 5 / 11 | PHE A 88VAL A 50ASN A 53GLY A 57THR A 119 | 1.46A | 17.95 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2AKE_A_TRPA479_0 (TRYPTOPHANYL-TRNASYNTHETASE) | L-Tryptophan | 5 / 12 | TYR A 65GLY A 49THR A 143GLN A 61PHE A 88 | 1.55A | 15.54 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5T8S_B_SAMB402_1 (S-ADENOSYLMETHIONINESYNTHASE) | S-Adenosylmethionine | 4 / 8 | ASP A 60LYS A 121SER A 56ASP A 59 | 1.49A | 18.84 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5HWA_A_GCSA301_1 (CHITOSANASE) | Glucosamine | 4 / 8 | GLY A 115THR A 113LEU A 117ASN A 118 | 1.22A | 20.23 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5KGP_A_GCSA407_1 (PREDICTEDACETYLTRANSFERASE) | Glucosamine | 4 / 8 | PRO A 58GLY A 94PRO A 120ASP A 60 | 1.57A | 18.99 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3AG2_P_CHDP1271_0 (CYTOCHROME C OXIDASEPOLYPEPTIDE 7A1CYTOCHROME C OXIDASESUBUNIT 3) | Cholic Acid | 5 / 7 | LEU A 34GLN A 36PHE A 44LEU A 137PHE A 31 | 1.65A | 18.7016.33 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3CYX_A_ROCA201_3 (HIV-1 PROTEASE) | Saquinavir | 6 / 12 | GLY A 115ALA A 116ASP A 60GLY A 63VAL A 111PRO A 100 | 1.60A | 23.49 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2VMY_A_GLYA502_0 (SERINEHYDROXYMETHYLTRANSFERASE) | Glycine | 4 / 7 | SER A 3HIS A 6HIS A 5LYS A 1 | 1.68A | 17.18 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3FZG_A_SAMA300_0 (16S RRNA METHYLASE) | S-Adenosylmethionine | 5 / 12 | THR A 93GLY A 57ILE A 52LEU A 117GLN A 48 | 1.46A | 16.28 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4GRK_A_KTRA713_1 (LACTOTRANSFERRIN) | Ketorolac | 4 / 5 | THR A 143GLY A 49VAL A 111PRO A 51 | 1.33A | 19.10 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3SXJ_A_SAMA258_0 (PUTATIVEMETHYLTRANSFERASE) | S-Adenosylmethionine | 5 / 12 | GLN A 61GLY A 92GLY A 57LEU A 117TYR A 101 | 1.59A | 22.35 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5TZO_A_7V7A202_1 (ENDO-1,4-BETA-XYLANASE A) | Fentanyl | 5 / 12 | VAL A 111ALA A 116PRO A 45TYR A 65ALA A 112 | 1.66A | 20.33 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2GQG_B_1N1B502_1 (PROTO-ONCOGENETYROSINE-PROTEINKINASE ABL1) | Dasatinib | 5 / 12 | LEU A 99ALA A 97THR A 93GLY A 63ALA A 116 | 1.16A | 20.71 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3CSJ_B_CBLB211_0 (GLUTATHIONES-TRANSFERASE P) | Chlorambucil | 5 / 9 | TYR A 65PHE A 44VAL A 111GLY A 63GLY A 49 | 1.55A | 20.56 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1N49_B_RITB301_2 (PROTEASE) | Ritonavir | 5 / 11 | GLY A 115ALA A 116ASP A 60GLY A 63PRO A 100 | 1.33A | 24.34 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2QD5_A_CHDA702_0 (FERROCHELATASE) | Cholic Acid | 3 / 3 | LEU A 99PRO A 100ARG A 66 | 0.73A | 16.81 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4L9Q_B_9TPB601_1 (SERUM ALBUMIN) | Teniposide | 5 / 12 | PRO A 146ALA A 151ILE A 108TYR A 65GLY A 102 | 1.54A | 11.75 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3UBO_A_ADNA353_1 (ADENOSINE KINASE) | Adenosine | 5 / 12 | ILE A 62ASP A 60GLY A 92SER A 56THR A 113 | 1.57A | 20.87 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5C0O_E_SAME301_0 (TRNA(ADENINE(58)-N(1))-METHYLTRANSFERASETRMI) | S-Adenosylmethionine | 5 / 12 | GLY A 49GLY A 47GLY A 142LEU A 139ALA A 112 | 1.49A | 19.23 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5YVN_A_ACTA305_0 (GLUTATHIONES-TRANSFERASEOMEGA-1) | Acetic acid | 4 / 6 | GLU A 152LEU A 137LEU A 145LEU A 34 | 1.58A | 22.95 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4A6D_A_SAMA1350_0 (HYDROXYINDOLEO-METHYLTRANSFERASE) | S-Adenosylmethionine | 5 / 12 | PHE A 88TYR A 65LEU A 139GLY A 49VAL A 111 | 1.55A | 18.16 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3V7P_A_BEZA430_0 (AMIDOHYDROLASEFAMILY PROTEIN) | Benzoic Acid | 4 / 7 | GLY A 57SER A 56PHE A 88PHE A 31 | 1.35A | 16.14 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2A1O_A_CAMA1422_0 (CYTOCHROME P450-CAM) | Camphor | 4 / 8 | LEU A 139VAL A 50GLY A 49VAL A 109 | 1.11A | 16.00 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5IWU_A_ACTA402_0 (MACROLIDE2'-PHOSPHOTRANSFERASE II) | Acetic acid | 4 / 6 | PHE A 88VAL A 50ILE A 62ASP A 60 | 1.32A | 20.39 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5N5D_B_SAMB303_0 (METHYLTRANSFERASE) | S-Adenosylmethionine | 5 / 12 | LEU A 34ALA A 33TYR A 87ILE A 62ALA A 112 | 1.41A | 22.22 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2XCT_G_CPFG1020_1 (DNA GYRASE SUBUNITB, DNA GYRASESUBUNIT A) | Ciprofloxacin | 3 / 3 | ARG A 73GLY A 74SER A 83 | 1.06A | 12.13 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3NDX_A_RITA100_1 (PROTEASE) | Ritonavir | 5 / 12 | GLY A 115ALA A 116ASP A 60GLY A 63PRO A 100 | 1.24A | 23.49 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3NMU_J_SAMJ228_0 (FIBRILLARIN-LIKERRNA/TRNA2'-O-METHYLTRANSFERASENOP5/NOP56 RELATEDPROTEIN) | S-Adenosylmethionine | 5 / 11 | TYR A 65GLY A 102ALA A 103ILE A 62ALA A 112 | 1.70A | 18.5723.53 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4WA9_A_AXIA9000_1 (TYROSINE-PROTEINKINASE ABL1) | Axitinib | 5 / 11 | LEU A 99ALA A 97THR A 93GLY A 63ALA A 116 | 1.15A | 20.34 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3J6P_B_TA1B502_1 (TUBULIN BETA CHAIN) | Paclitaxel | 5 / 12 | GLU A 96LEU A 137THR A 54PRO A 95GLY A 92 | 1.64A | 15.51 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4K50_A_ACTA506_0 (RNA POLYMERASE3D-POL) | Acetic acid | 3 / 3 | VAL A 109GLY A 107LYS A 105 | 1.05A | 15.47 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1RL8_A_RITA9001_1 (PROTEASE RETROPEPSIN) | Ritonavir | 5 / 12 | GLY A 115ALA A 116ASP A 60GLY A 63PRO A 100 | 1.24A | 23.49 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4KQI_A_NIOA403_1 (NICOTINATE-NUCLEOTIDE--DIMETHYLBENZIMIDAZOLEPHOSPHORIBOSYLTRANSFERASE) | Niacin | 5 / 9 | THR A 144GLY A 142GLY A 49PHE A 44GLY A 47 | 1.58A | 19.69 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4WG0_A_CHDA103_0 (NUCLEAR RECEPTORCOACTIVATOR 2) | Cholic Acid | 4 / 8 | ASN A 53LEU A 139ALA A 33LEU A 34 | 1.02A | 8.13 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3P2K_D_SAMD6735_0 (16S RRNA METHYLASE) | S-Adenosylmethionine | 5 / 12 | GLY A 125PRO A 95ALA A 97LEU A 91SER A 29 | 1.50A | 18.83 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2A1M_B_CAMB2422_0 (CYTOCHROME P450-CAM) | Camphor | 4 / 8 | VAL A 50GLY A 49THR A 143ILE A 52 | 1.03A | 16.00 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6FGD_A_ACTA819_0 (GEPHYRIN) | Acetic acid | 3 / 3 | ARG A 67GLY A 107GLU A 106 | 1.54A | 15.31 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2VDV_E_SAME1287_0 (TRNA(GUANINE-N(7)-)-METHYLTRANSFERASE) | S-Adenosylmethionine | 5 / 12 | GLY A 47GLU A 114ALA A 116PHE A 44THR A 143 | 1.58A | 20.25 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4XO7_A_ASDA402_1 (ALDO-KETO REDUCTASEFAMILY 1 MEMBER C2) | 4-Androstenedione | 4 / 7 | TYR A 150VAL A 136LEU A 145LEU A 139 | 1.55A | 16.82 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1N49_D_RITD401_2 (PROTEASE) | Ritonavir | 4 / 6 | GLY A 63ILE A 62PRO A 95ILE A 124 | 1.35A | 24.34 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6JNH_A_ASCA202_0 (PHOSPHOPANTETHEINEADENYLYLTRANSFERASE) | Vitamin C | 3 / 3 | ASN A 53PRO A 51GLN A 48 | 1.06A | 20.22 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4MJ8_B_SPMB201_1 (SPERMIDINEN1-ACETYLTRANSFERASE) | Spermine | 4 / 8 | ASN A 104GLU A 41GLU A 106ARG A 67 | 1.78A | 21.76 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4FO4_B_MOAB502_1 (INOSINE5'-MONOPHOSPHATEDEHYDROGENASE) | Mycophenolic acid | 4 / 8 | ASN A 118GLY A 115THR A 113GLY A 63 | 1.00A | 18.45 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4CP4_A_CAMA416_0 (CYTOCHROME P450-CAM) | Camphor | 4 / 7 | PHE A 88LEU A 139VAL A 109VAL A 111 | 1.39A | 15.54 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3H5G_B_LEIB16_0 (COIL SER L16D-PEN) | Penicillamine | 4 / 5 | LEU A 34GLN A 138LEU A 139GLU A 152 | 1.60A | 9.49 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5X7F_A_SAMA301_0 (PUTATIVEO-METHYLTRANSFERASERV1220C) | S-Adenosylmethionine | 5 / 12 | GLY A 115ALA A 112ALA A 116ASP A 60TYR A 101 | 1.18A | 27.54 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4PB1_A_RBVA501_1 (NUPC FAMILY PROTEIN) | Ribavirin | 5 / 12 | GLY A 94ALA A 97ASN A 53SER A 56ILE A 124 | 1.66A | 14.18 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6GBN_C_ADNC501_2 (-) | Adenosine | 4 / 5 | GLN A 36THR A 35THR A 144GLY A 38 | 1.44A | 17.80 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3NDT_A_ROCA101_1 (PROTEASE) | Saquinavir | 5 / 12 | GLY A 115ALA A 116ASP A 60GLY A 63PRO A 100 | 1.26A | 23.49 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4KOU_A_C04A207_1 (UNCHARACTERIZEDPROTEIN) | Cefixime | 3 / 3 | GLY A 49GLU A 114THR A 113 | 0.97A | 20.71 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1NBI_C_SAMC2293_0 (GLYCINEN-METHYLTRANSFERASE) | S-Adenosylmethionine | 5 / 12 | GLY A 125ALA A 134SER A 29GLY A 57SER A 56 | 1.75A | 20.92 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1DMA_A_NCAA700_0 (EXOTOXIN A) | Nicotinamide | 4 / 7 | GLY A 57LEU A 91TYR A 90GLU A 96 | 1.15A | 20.00 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3N9J_A_EAAA210_1 (GLUTATHIONES-TRANSFERASE P) | Etacrynic acid | 4 / 8 | TYR A 65PHE A 44VAL A 111GLY A 49 | 1.43A | 21.03 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3CYX_A_ROCA201_1 (HIV-1 PROTEASE) | Saquinavir | 6 / 12 | GLY A 115ALA A 116ASP A 60GLY A 63VAL A 111PRO A 100 | 1.59A | 23.49 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2GQG_A_1N1A501_1 (PROTO-ONCOGENETYROSINE-PROTEINKINASE ABL1) | Dasatinib | 5 / 12 | LEU A 99ALA A 97THR A 93GLY A 63ALA A 116 | 1.07A | 20.71 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5L66_K_BO2K301_1 (PROTEASOME SUBUNITBETATYPE-8,PROTEASOMESUBUNIT BETA TYPE-5PROTEASOME SUBUNITBETATYPE-6,PROTEASOMESUBUNIT BETATYPE-1,PROTEASOMESUBUNIT BETATYPE-6,PROTEASOMESUBUNIT BETATYPE-1,PROTEASOMESUBUNIT BETA TYPE-6) | Bortezomib | 5 / 10 | THR A 32ALA A 134THR A 135GLY A 153SER A 158 | 1.72A | 20.1018.99 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3K4V_B_ROCB201_1 (HIV-1 PROTEASE) | Saquinavir | 5 / 12 | GLY A 115ALA A 116ASP A 60GLY A 63PRO A 100 | 1.20A | 23.49 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4A6N_C_T1CC392_1 (TETX2 PROTEIN) | Tigecycline | 5 / 11 | ASN A 53GLN A 61ASN A 118GLY A 57SER A 56 | 1.59A | 24.64 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2NPN_A_SAMA4633_0 (PUTATIVE COBALAMINSYNTHESIS RELATEDPROTEIN) | S-Adenosylmethionine | 5 / 9 | THR A 32ALA A 33LEU A 82LEU A 34THR A 35 | 1.42A | 19.84 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5A1I_A_ADNA407_1 (S-ADENOSYLMETHIONINESYNTHASE ISOFORMTYPE-2) | Adenosine | 4 / 8 | ASP A 60LYS A 121SER A 56ASP A 59 | 1.54A | 16.67 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1H4O_B_BEZB1162_0 (PEROXIREDOXIN 5) | Benzoic Acid | 4 / 8 | THR A 119PRO A 58GLY A 57THR A 113 | 1.48A | 20.23 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6FBN_B_SAMB401_1 (S-ADENOSYLMETHIONINESYNTHASE ISOFORMTYPE-2) | S-Adenosylmethionine | 4 / 8 | ASP A 60LYS A 121SER A 56ASP A 59 | 1.49A | 17.19 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2NMY_A_ROCA401_2 (PROTEASE) | Saquinavir | 5 / 12 | GLY A 115ALA A 116ASP A 60GLY A 63PRO A 100 | 1.23A | 23.49 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5G5J_A_MF8A600_1 (CYTOCHROME P450 3A4) | Metformin | 4 / 4 | ARG A 127SER A 29ARG A 85ALA A 33 | 1.79A | 15.77 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1JB0_B_PQNB2002_1 (PHOTOSYSTEM I P700CHLOROPHYLL AAPOPROTEIN A2) | Phylloquinone | 5 / 11 | PHE A 149ARG A 85TRP A 86ALA A 33LEU A 34 | 1.76A | 15.85 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1MUI_B_AB1B100_2 (PROTEASE) | Lopinavir | 5 / 12 | GLY A 115ALA A 116ASP A 60GLY A 63PRO A 100 | 1.33A | 23.49 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4TWD_C_377C401_1 (CYS-LOOPLIGAND-GATED IONCHANNEL) | Memantine | 4 / 6 | ASN A 53TYR A 65LEU A 137PHE A 44 | 1.79A | 19.16 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3DOU_A_SAMA1_0 (RIBOSOMAL RNA LARGESUBUNITMETHYLTRANSFERASE J) | S-Adenosylmethionine | 5 / 12 | SER A 154GLY A 156GLY A 157LEU A 137ALA A 134 | 1.27A | 20.92 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4FOR_A_FLPA711_1 (LACTOTRANSFERRIN) | Flurbiprofen | 4 / 7 | THR A 54PRO A 58ASN A 55GLY A 92 | 1.21A | 19.10 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2W98_A_P1ZA1352_1 (PROSTAGLANDINREDUCTASE 2) | Phenylbutazone | 4 / 7 | TYR A 65LEU A 137ASN A 53TYR A 87 | 1.31A | 17.00 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3NDU_D_ROCD100_2 (PROTEASE) | Saquinavir | 5 / 12 | GLY A 115ALA A 116ASP A 60GLY A 63PRO A 100 | 1.20A | 23.49 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5T2Z_B_017B201_1 (PROTEASE) | Darunavir | 5 / 12 | GLY A 115ALA A 116ASP A 60GLY A 63PRO A 100 | 1.37A | 25.40 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1T88_A_CAMA1422_0 (CYTOCHROME P450-CAM) | Camphor | 4 / 7 | LEU A 139VAL A 50GLY A 49VAL A 109 | 1.14A | 15.79 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2P16_A_GG2A298_1 (COAGULATION FACTOR X(EC 3.4.21.6)(STUART FACTOR)(STUART-PROWERFACTOR)) | Apixaban | 5 / 12 | TYR A 65PHE A 31ASP A 60ALA A 116GLY A 92 | 1.48A | 19.05 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4MM8_A_RFXA603_1 (TRANSPORTER) | Fluoxetine | 5 / 12 | ASP A 122TYR A 89TYR A 90SER A 56GLY A 57 | 1.47A | 14.12 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4KAH_A_ADNA401_2 (PROBABLE SUGARKINASE PROTEIN) | Adenosine | 3 / 3 | SER A 29TYR A 87PRO A 129 | 1.61A | 20.17 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2W26_A_RIVA1001_1 (ACTIVATED FACTOR XAHEAVY CHAIN) | Rivaroxaban | 5 / 12 | TYR A 65PHE A 31ASP A 60ALA A 116GLY A 92 | 1.46A | 19.05 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4EB4_A_D16A402_1 (THYMIDYLATE SYNTHASE) | Raltitrexed | 5 / 12 | PHE A 31ILE A 124ASP A 60GLY A 57ALA A 97 | 1.77A | 18.51 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ROD_D_NCAD302_0 (NICOTINAMIDEN-METHYLTRANSFERASE) | Nicotinamide | 4 / 7 | LEU A 91ASP A 60ALA A 116TYR A 101 | 1.11A | 24.82 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3NDW_A_RITA100_1 (PROTEASE) | Ritonavir | 5 / 12 | GLY A 115ALA A 116ASP A 60GLY A 63PRO A 100 | 1.32A | 23.49 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4DXU_A_ACAA711_1 (LACTOTRANSFERRIN) | Aminocaproic Acid | 4 / 6 | GLY A 63VAL A 50GLY A 115GLU A 114 | 1.37A | 19.10 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4MA3_L_ACTL301_0 (C2095 HEAVY CHAINC2095 LIGHT CHAIN) | Acetic acid | 3 / 3 | PRO A 58ASN A 55HIS A 123 | 1.30A | 23.4720.98 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3WRK_A_CAMA502_0 (CAMPHOR5-MONOOXYGENASE) | Camphor | 4 / 5 | LEU A 91GLY A 63ILE A 108VAL A 109 | 1.39A | 15.17 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3TKG_C_ROCC901_1 (PROTEASE) | Saquinavir | 5 / 12 | GLY A 115ALA A 116ASP A 60GLY A 63PRO A 100 | 1.18A | 25.36 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3TNE_A_RITA401_2 (SECRETED ASPARTICPROTEASE) | Ritonavir | 4 / 6 | PRO A 51TYR A 150THR A 144THR A 143 | 1.45A | 17.84 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1HXW_B_RITB301_2 (HIV-1 PROTEASE) | Ritonavir | 5 / 11 | GLY A 115ALA A 116ASP A 60GLY A 63PRO A 100 | 1.49A | 23.49 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2NMZ_B_ROCB401_3 (PROTEASE) | Saquinavir | 5 / 12 | GLY A 115ALA A 116ASP A 60GLY A 63PRO A 100 | 1.20A | 23.49 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6JOG_A_ASCA202_0 (PHOSPHOPANTETHEINEADENYLYLTRANSFERASE) | Vitamin C | 3 / 3 | ASN A 53PRO A 51GLN A 48 | 1.04A | 20.22 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1BX4_A_ADNA355_1 (PROTEIN (ADENOSINEKINASE)) | Adenosine | 5 / 12 | VAL A 50ALA A 116GLY A 115ALA A 112ILE A 62 | 1.40A | 17.70 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5N0O_A_SAMA501_1 (PEPTIDEN-METHYLTRANSFERASE) | S-Adenosylmethionine | 3 / 3 | ALA A 134GLN A 138THR A 32 | 1.40A | 16.12 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3S56_A_ROCA201_1 (PROTEASE) | Saquinavir | 5 / 12 | GLY A 115ALA A 116ASP A 60GLY A 63PRO A 100 | 1.25A | 24.16 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1JHA_A_NIOA991_1 (NICOTINATEMONONUCLEOTIDE:5,6-DIMETHYLBENZIMIDAZOLEPHOSPHORIBOSYLTRANSFERASE) | Niacin | 5 / 8 | THR A 144GLY A 142GLY A 49PHE A 44GLY A 47 | 1.63A | 19.69 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ACB_C_DXCC1478_0 (TRANSLATIONELONGATION FACTORSELB) | Deoxycholic Acid | 4 / 6 | ASP A 60THR A 54ILE A 124THR A 119 | 1.58A | 15.02 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6F88_B_STRB502_1 (CYTOCHROME P450CYP260A1) | Progesterone | 4 / 6 | ALA A 151SER A 154THR A 135ASN A 53 | 1.34A | 17.96 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4L64_A_C2FA802_0 (5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE--HOMOCYSTEINEMETHYLTRANSFERASE) | Levomefolic acid | 4 / 7 | TYR A 87ARG A 85VAL A 136TRP A 30 | 1.80A | 12.10 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1JR1_B_MOAB1333_1 (INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE 2) | Mycophenolic acid | 4 / 8 | ASN A 118GLY A 115THR A 113GLY A 63 | 0.89A | 17.31 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4KHP_A_PARA1606_1 (16S RIBOSOMAL RNA30S RIBOSOMALPROTEIN S930S RIBOSOMALPROTEIN S10) | Paromomycin | 3 / 3 | TYR A 87ARG A 127SER A 29 | 1.64A | 22.5623.87 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2QM9_A_TDZA201_1 (FATTY ACID-BINDINGPROTEIN, ADIPOCYTE) | Troglitazone | 5 / 12 | ALA A 68SER A 29THR A 32ALA A 33ARG A 70 | 1.70A | 19.77 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1YAJ_A_BEZA11_0 (CES1 PROTEIN) | Benzoic Acid | 4 / 4 | LEU A 137SER A 154LEU A 34LEU A 139 | 1.66A | 16.43 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4PD5_A_GEOA501_1 (NUPC FAMILY PROTEIN) | Gemcitabine | 5 / 12 | GLY A 47GLN A 48VAL A 111TYR A 65ASN A 53 | 1.35A | 14.18 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3FUP_B_MI1B1_1 (TYROSINE-PROTEINKINASE JAK2) | Tofacitinib | 5 / 12 | GLY A 63GLY A 102VAL A 111LEU A 34LEU A 42 | 1.20A | 23.31 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4F3T_A_IPHA902_0 (PROTEIN ARGONAUTE-2) | Phenol | 4 / 6 | LEU A 99TYR A 101LEU A 91TYR A 64 | 1.52A | 11.03 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5T7B_A_IPHA902_0 (PROTEIN ARGONAUTE-2) | Phenol | 4 / 7 | LEU A 99TYR A 101LEU A 91TYR A 64 | 1.43A | 11.03 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3V4T_H_ACTH503_0 (UDP-N-ACETYLGLUCOSAMINE1-CARBOXYVINYLTRANSFERASE) | Acetic acid | 4 / 7 | ALA A 103ILE A 108TRP A 110GLY A 63 | 1.62A | 14.56 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3QXY_B_SAMB6735_0 (N-LYSINEMETHYLTRANSFERASESETD6TRANSCRIPTION FACTORP65) | S-Adenosylmethionine | 5 / 11 | VAL A 111GLY A 63TYR A 89ALA A 33PHE A 44 | 1.79A | 16.046.33 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1SV5_A_65BA600_0 (REVERSETRANSCRIPTASE) | Etravirine | 5 / 10 | LEU A 34TYR A 150PRO A 140LEU A 137TYR A 65 | 1.79A | 15.01 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5X24_A_LSNA502_1 (CYTOCHROME P450 2C9) | Losartan | 5 / 12 | ALA A 33PHE A 31LEU A 34GLY A 63THR A 113 | 1.46A | 16.93 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2NNP_A_ROCA401_1 (PROTEASE) | Saquinavir | 5 / 11 | GLY A 115ALA A 116ASP A 60GLY A 63PRO A 100 | 1.40A | 23.49 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2WEK_B_DIFB1376_1 (ZINC-BINDING ALCOHOLDEHYDROGENASEDOMAIN-CONTAININGPROTEIN 2) | Diclofenac | 5 / 7 | VAL A 136GLY A 153ALA A 151LEU A 34SER A 154 | 1.71A | 19.20 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5PBE_A_TYLA2001_1 (BROMODOMAIN ADJACENTTO ZINC FINGERDOMAIN PROTEIN 2B) | Acetaminophen | 4 / 6 | PRO A 140VAL A 111TYR A 65ASN A 53 | 1.22A | 23.53 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3EKX_B_1UNB201_1 (PROTEASE) | Nelfinavir | 5 / 11 | GLY A 115ALA A 116ASP A 60GLY A 63PRO A 100 | 1.32A | 22.82 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1L5R_A_RBFA859_1 (GLYCOGENPHOSPHORYLASE, LIVERFORM) | Riboflavin | 5 / 11 | ASN A 118LEU A 99TYR A 89ALA A 116GLY A 115 | 1.63A | 11.22 | None |