POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		1jmy BILE-SALT-ACTIVATED
LIPASE
(Homo
sapiens)		4 / 7ILE A 521
PHE A 351
TYR A 367
VAL A 339
None
1.07A20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		1ygu LEUKOCYTE COMMON
ANTIGEN
(Homo
sapiens)		4 / 7GLU A 894
GLU A1167
TYR A 767
VAL A 722
None
0.75A20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		2h8r HEPATOCYTE NUCLEAR
FACTOR 1-BETA
(Homo
sapiens)		4 / 7GLU A 138
GLU A 178
HIS A 284
VAL A 278
None
0.95A20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		2iik 3-KETOACYL-COA
THIOLASE,
PEROXISOMAL
(Homo
sapiens)		4 / 7GLU A 223
ILE A 389
PHE A 220
HIS A 378
None
1.10A20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		2xss CGMP-SPECIFIC 3',
5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens)		4 / 7GLU A 390
GLU A 392
TYR A 409
VAL A 415
None
1.06A21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		4cak INTEGRIN ALPHA-IIB
INTEGRIN BETA-3
(Homo
sapiens)		4 / 7GLU A 324
PHE B 248
HIS B 274
VAL B 193
None
1.07A16.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		4x0q DNA POLYMERASE THETA
(Homo
sapiens)		4 / 7GLU A2049
ILE A2053
HIS A2236
VAL A2232
None
None
None
GOL  A2602 (-4.5A)
0.96A16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		5fi0 PHOSPHATIDYLINOSITOL
3,4,5-TRISPHOSPHATE-
DEPENDENT RAC
EXCHANGER 1
PROTEIN,PHOSPHATIDYL
INOSITOL
3,4,5-TRISPHOSPHATE-
DEPENDENT RAC
EXCHANGER 1 PROTEIN
(Homo
sapiens)		4 / 7ILE A 331
PHE A 291
HIS A 349
VAL A 355
None
1.06A20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		5hmp UNCONVENTIONAL
MYOSIN-VC
(Homo
sapiens)		4 / 7GLU A 457
ILE A 494
PHE A 551
HIS A 466
None
1.01A17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		5kz5 CYSTEINE
DESULFURASE,
MITOCHONDRIAL
(Homo
sapiens)		4 / 7GLU 1 416
TYR 1 317
HIS 1 319
VAL 1 310
None
0.93A20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		5l2q SERINE/THREONINE-PRO
TEIN KINASE 40
(Homo
sapiens)		4 / 7ILE C 278
GLU C 281
PHE C 283
VAL C 262
None
1.12A23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		5of4 GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT 2
(Homo
sapiens)		4 / 7ILE E 170
PHE E  91
TYR E 228
HIS E 227
None
0.98A21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		5v9p LYSINE-SPECIFIC
DEMETHYLASE 5A
(Homo
sapiens)		4 / 7GLU A 614
PHE A 666
HIS A 702
VAL A 653
None
None
ZN  A 902 (-3.8A)
None
1.02A16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		1fns VON WILLEBRAND
FACTOR
(Homo
sapiens)		4 / 7PHE A 634
TYR A 637
VAL A 638
GLU A 626
None
1.12A20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		1hnf CD2
(Homo
sapiens)		4 / 7PHE A  98
TYR A  81
VAL A  83
ILE A  33
None
NA  A 629 (-4.7A)
None
None
0.79A17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		1nbq JUNCTIONAL ADHESION
MOLECULE 1
(Homo
sapiens)		4 / 7PHE A  55
TYR A  52
VAL A  31
GLU A 113
None
1.07A20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		2ija ARYLAMINE
N-ACETYLTRANSFERASE
1
(Homo
sapiens)		4 / 7TYR A  94
VAL A  93
ILE A 106
GLU A 182
UNX  A 502 (-4.3A)
None
None
None
1.07A24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		2qc7 ENDOPLASMIC
RETICULUM PROTEIN
ERP29
(Homo
sapiens)		4 / 7PHE A  46
VAL A  91
ILE A  93
ASN A 101
None
0.98A20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		3ihp UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 5
(Homo
sapiens)		4 / 7PHE A 461
TYR A 568
VAL A 570
ILE A 827
None
1.11A17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		3kq0 ALPHA-1-ACID
GLYCOPROTEIN 1
(Homo
sapiens)		4 / 7PHE A  32
TYR A  37
VAL A  41
ILE A  44
None
1.08A19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		3pg7 NEUROFIBROMIN
(Homo
sapiens)		4 / 7PHE A1719
VAL A1736
ILE A1805
GLU A1794
None
1.08A21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		3pm0 CYTOCHROME P450 1B1
(Homo
sapiens)		4 / 7TYR A 214
VAL A 199
ARG A 213
ASN A 203
None
1.05A20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		4i8v CYTOCHROME P450 1A1
(Homo
sapiens)		4 / 7TYR A 207
VAL A 192
ARG A 206
ASN A 196
None
1.05A20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		5te1 ATP-CITRATE SYNTHASE
(Homo
sapiens)		4 / 7PHE A 493
VAL A 568
ILE A 591
GLU A 683
None
1.01A16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		5tet ATP-CITRATE SYNTHASE
(Homo
sapiens)		4 / 7PHE B 493
VAL B 568
ILE B 591
GLU B 683
None
1.00A19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		5udy ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 7
(Homo
sapiens)		4 / 7TYR A 194
VAL A  36
ILE A 243
GLU A 171
None
None
None
FUC  A 508 ( 4.3A)
0.99A20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		6f1v CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens)		4 / 7TYR f 527
VAL f 523
ILE f 520
ASN f 524
None
1.06A12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_B_ZPCB1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		4k81 GROWTH FACTOR
RECEPTOR-BOUND
PROTEIN 14
(Homo
sapiens)		5 / 12ILE A 110
GLU A 161
GLU A 117
TYR A 186
VAL A 133
GOL  A 404 ( 4.3A)
None
None
None
None
1.28A21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_B_ZPCB1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		4nky STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE
(Homo
sapiens)		5 / 12ILE A 393
ASN A 395
HIS A  48
VAL A 215
PHE A  42
None
1.38A24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_B_ZPCB1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		4zwe DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1
(Homo
sapiens)		5 / 12ILE A 191
GLU A 270
TYR A 298
VAL A 179
PHE A 267
None
1.43A20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_B_ZPCB1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		5e84 78 KDA
GLUCOSE-REGULATED
PROTEIN
(Homo
sapiens)		5 / 12PHE A 544
ILE A 145
GLU A 547
GLU A 155
VAL A  92
None
1.41A19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_B_ZPCB1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		6ehr RAS-RELATED
GTP-BINDING PROTEIN
A
(Homo
sapiens)		5 / 12ILE F 198
GLU F 188
HIS F 216
VAL F 274
PHE F 297
None
1.49A18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_C_ZPCC1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		1ao3 VON WILLEBRAND
FACTOR
(Homo
sapiens)		5 / 12VAL A  73
ILE A  33
GLU A  24
ILE A 169
VAL A  45
None
1.14A21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_C_ZPCC1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		3b0q PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA
(Homo
sapiens)		5 / 12PHE A 368
VAL A 339
ILE A 341
GLU A 365
ILE A 445
None
MC5  A   1 (-4.6A)
MC5  A   1 (-4.5A)
None
None
1.27A20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_C_ZPCC1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA
(Homo
sapiens)		5 / 12PHE D 368
VAL D 339
ILE D 341
GLU D 365
ILE D 445
None
None
PLB  D 701 (-3.6A)
None
None
1.16A21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_C_ZPCC1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		4acq ALPHA-2-MACROGLOBULI
N
(Homo
sapiens)		5 / 12PHE A 300
VAL A 266
ILE A 268
TYR A 301
VAL A 304
None
0.97A11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_C_ZPCC1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct)		5 / 12PHE A3243
ILE A3211
GLU A3196
GLU A3249
VAL A2878
None
1.29A6.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_C_ZPCC1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		5bqm SOMATOLIBERIN,BOTULI
NUM NEUROTOXIN TYPE
D
(Clostridium
botulinum;
Homo
sapiens)		5 / 12VAL B 630
ILE B 700
GLU B 723
TYR B 605
VAL B 513
None
1.25A20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_C_ZPCC1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		5hcc COMPLEMENT C5
(Homo
sapiens)		5 / 12PHE B 111
VAL B 106
ILE B  54
HIS B 110
VAL B  71
None
1.16A19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		1kfu M-CALPAIN LARGE
SUBUNIT
(Homo
sapiens)		4 / 8PHE L 475
VAL L 409
ILE L 499
GLU L 460
None
0.91A17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA
(Homo
sapiens)		4 / 8PHE D 368
VAL D 339
ILE D 341
GLU D 365
None
None
PLB  D 701 (-3.6A)
None
1.10A21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		3pg7 NEUROFIBROMIN
(Homo
sapiens)		4 / 8PHE A1719
VAL A1736
ILE A1805
GLU A1794
None
1.01A21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		4f92 U5 SMALL NUCLEAR
RIBONUCLEOPROTEIN
200 KDA HELICASE
(Homo
sapiens)		4 / 8VAL B1099
MET B1092
ILE B1095
GLU B1226
None
1.07A10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		5cmn LATROPHILIN-3
(Homo
sapiens)		4 / 8PHE E 314
VAL E 367
ILE E 364
ASN E 312
None
CA  E 401 (-4.8A)
None
CA  E 401 (-3.3A)
1.01A22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		5ofb MORC FAMILY CW-TYPE
ZINC FINGER PROTEIN
2
(Homo
sapiens)		4 / 8TYR B 418
VAL B 416
ILE B 384
ASN B 386
None
1.10A12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		5te1 ATP-CITRATE SYNTHASE
(Homo
sapiens)		4 / 8PHE A 493
VAL A 568
ILE A 591
GLU A 683
None
1.02A16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		5tet ATP-CITRATE SYNTHASE
(Homo
sapiens)		4 / 8PHE B 493
VAL B 568
ILE B 591
GLU B 683
None
0.99A19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		5udy ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 7
(Homo
sapiens)		4 / 8TYR A 194
VAL A  36
ILE A 243
GLU A 171
None
None
None
FUC  A 508 ( 4.3A)
0.93A20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		6caa ELECTROGENIC SODIUM
BICARBONATE
COTRANSPORTER 1
(Homo
sapiens)		4 / 8PHE A 865
TYR A 862
VAL A 864
ILE A 692
None
1.04A13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		1xr0 FGFR SIGNALLING
ADAPTOR SNT-1
(Homo
sapiens)		4 / 7GLU B  44
ILE B  46
GLU B  39
VAL B  13
None
1.08A16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		1ygu LEUKOCYTE COMMON
ANTIGEN
(Homo
sapiens)		4 / 7GLU A 894
GLU A1167
TYR A 767
VAL A 722
None
0.87A20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		2h8r HEPATOCYTE NUCLEAR
FACTOR 1-BETA
(Homo
sapiens)		4 / 7GLU A 138
GLU A 178
HIS A 284
VAL A 278
None
0.94A20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		2xss CGMP-SPECIFIC 3',
5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens)		4 / 7GLU A 390
GLU A 392
TYR A 409
VAL A 415
None
1.04A21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		4nzr PGT135 HEAVY CHAIN
PROTEIN M TD
(Homo
sapiens;
Mycoplasma
genitalium)		4 / 7GLU M 427
ILE M 449
TYR H  32
HIS H  95
None
0.71A21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		4x0q DNA POLYMERASE THETA
(Homo
sapiens)		4 / 7GLU A2049
ILE A2053
HIS A2236
VAL A2232
None
None
None
GOL  A2602 (-4.5A)
1.03A16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		5fwm HEAT SHOCK PROTEIN
HSP 90 BETA
(Homo
sapiens)		4 / 7ILE A 441
TYR A 457
HIS A 458
VAL A 494
None
1.09A18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		5kz5 CYSTEINE
DESULFURASE,
MITOCHONDRIAL
(Homo
sapiens)		4 / 7GLU 1 416
TYR 1 317
HIS 1 319
VAL 1 310
None
0.94A20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		5l2q SERINE/THREONINE-PRO
TEIN KINASE 40
(Homo
sapiens)		4 / 7ILE C 278
GLU C 281
PHE C 283
VAL C 262
None
1.08A23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		5zqz TRIFUNCTIONAL ENZYME
SUBUNIT ALPHA,
MITOCHONDRIAL
(Homo
sapiens)		4 / 7GLU A 238
ILE A 237
HIS A  40
VAL A  75
None
1.06A12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		1by7 PROTEIN (PLASMINOGEN
ACTIVATOR
INHIBITOR-2)
(Homo
sapiens)		4 / 8VAL A 173
ILE A 169
ASN A 170
GLU A 315
None
1.10A20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		1kfu M-CALPAIN LARGE
SUBUNIT
(Homo
sapiens)		4 / 8PHE L 475
VAL L 409
ILE L 499
GLU L 460
None
0.80A17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		1lpb LIPASE
(Homo
sapiens)		4 / 8PHE B 386
TYR B 340
VAL B 342
ILE B 420
None
0.88A20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		1q9p HIV-1 PROTEASE
(Homo
sapiens)		4 / 8TYR A  59
VAL A  75
ILE A  64
GLU A  35
None
1.10A16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		2qc7 ENDOPLASMIC
RETICULUM PROTEIN
ERP29
(Homo
sapiens)		4 / 8PHE A  46
VAL A  91
ILE A  93
ASN A 101
None
1.00A20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		3ihp UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 5
(Homo
sapiens)		4 / 8PHE A 461
TYR A 568
VAL A 570
ILE A 827
None
1.05A17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		3kq0 ALPHA-1-ACID
GLYCOPROTEIN 1
(Homo
sapiens)		4 / 8PHE A  32
TYR A  37
VAL A  41
ILE A  44
None
1.06A19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		4hpf POTASSIUM CHANNEL
SUBFAMILY U MEMBER 1
(Homo
sapiens)		4 / 8TYR A 917
ILE A 472
ASN A 471
GLU A 558
None
1.03A18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		5mc5 XAA-PRO DIPEPTIDASE
(Homo
sapiens)		4 / 8PHE A  96
TYR A  83
VAL A  85
ILE A  45
None
0.64A14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2
(Homo
sapiens)		4 / 6GLU A 404
TYR A 482
HIS A 479
PHE A 403
None
1.20A21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		2c47 CASEIN KINASE 1
GAMMA 2 ISOFORM
(Homo
sapiens)		4 / 6GLU A 169
PHE A 130
TYR A 218
HIS A 240
None
1.14A21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		2wmo DEDICATOR OF
CYTOKINESIS PROTEIN
9
(Homo
sapiens)		4 / 6TYR A 155
HIS A 229
VAL A 158
PHE A 287
None
0.77A19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		3a5k TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 1
(Homo
sapiens)		4 / 6TYR A 176
HIS A 175
VAL A 213
PHE A 191
None
1.15A20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		3bdl STAPHYLOCOCCAL
NUCLEASE
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens)		4 / 6GLU A 726
HIS A 670
VAL A 673
PHE A 737
None
1.05A20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		3d3m EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4
GAMMA 2
(Homo
sapiens)		4 / 6GLU A 864
PHE A 866
HIS A 821
VAL A 769
None
1.08A18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		3lqz HLA CLASS II
HISTOCOMPATIBILITY
ANTIGEN, DP ALPHA 1
CHAIN
(Homo
sapiens)		4 / 6GLU A  21
HIS A 108
VAL A 165
PHE A 137
None
1.22A19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		3pmi PWWP
DOMAIN-CONTAINING
PROTEIN MUM1
(Homo
sapiens)		4 / 6PHE A 466
TYR A 496
VAL A 521
PHE A 509
None
1.21A16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		4avx HEPATOCYTE GROWTH
FACTOR-REGULATED
TYROSINE KINASE
SUBSTRATE
(Homo
sapiens)		4 / 6GLU A   9
TYR A  44
VAL A  79
PHE A   8
None
EDO  A1234 (-4.1A)
None
None
1.21A18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		4btm TAU-TUBULIN KINASE 1
(Homo
sapiens)		4 / 6GLU A  71
PHE A 126
TYR A  73
VAL A  84
None
1.21A20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		4i1f E3 UBIQUITIN-PROTEIN
LIGASE PARKIN
(Homo
sapiens)		4 / 6PHE A 208
HIS A 461
VAL A 465
PHE A 210
None
ZN  A 508 (-3.2A)
None
None
1.08A20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		4y07 NEDD4-LIKE E3
UBIQUITIN-PROTEIN
LIGASE WWP2
(Homo
sapiens)		4 / 6GLU A 526
TYR A 604
HIS A 601
PHE A 525
None
1.19A22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		4y63 HISTO-BLOOD GROUP
ABO SYSTEM
TRANSFERASE
(Homo
sapiens)		4 / 6GLU A 138
PHE A 133
HIS A 145
VAL A 204
None
1.19A21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		5c5b DCC-INTERACTING
PROTEIN 13-BETA
(Homo
sapiens)		4 / 6TYR B  88
HIS B  87
VAL B  82
PHE B 225
None
1.19A21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		5c7m E3 UBIQUITIN-PROTEIN
LIGASE ITCHY HOMOLOG
(Homo
sapiens)		4 / 6GLU A 559
TYR A 637
HIS A 634
PHE A 558
None
1.19A21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		5c7m E3 UBIQUITIN-PROTEIN
LIGASE ITCHY HOMOLOG
(Homo
sapiens)		4 / 6GLU A 559
TYR A 637
HIS A 634
PHE A 562
None
1.02A21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		5dux GALECTIN-4
(Homo
sapiens)		4 / 6TYR B 112
HIS B 111
VAL B 115
PHE B  50
None
1.11A19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		5hpk E3 UBIQUITIN-PROTEIN
LIGASE NEDD4-LIKE
(Homo
sapiens)		4 / 6GLU A 609
TYR A 689
HIS A 686
PHE A 608
None
1.20A22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		5i8k HHH1 FAB HEAVY CHAIN
(Homo
sapiens)		5 / 6GLU H   2
TYR H  32
HIS H  33
VAL H  76
PHE H  27
None
1.34A20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		5m9o STAPHYLOCOCCAL
NUCLEASE
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens)		4 / 6GLU A 751
HIS A 695
VAL A 698
PHE A 762
None
1.01A22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		5ojj UBIQUITIN-CONJUGATIN
G ENZYME E2 T
(Homo
sapiens)		4 / 6GLU A 131
TYR A  75
HIS A 150
PHE A 139
None
1.07A18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		5u4r VRC 315 53-1A09 FAB
HEAVY CHAIN
(Homo
sapiens)		4 / 6TYR A  32
HIS A  33
VAL A  78
PHE A  27
None
0.91A20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		5v9p LYSINE-SPECIFIC
DEMETHYLASE 5A
(Homo
sapiens)		4 / 6GLU A 614
PHE A 666
HIS A 702
VAL A 653
None
None
ZN  A 902 (-3.8A)
None
1.11A16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		1kfu M-CALPAIN LARGE
SUBUNIT
(Homo
sapiens)		4 / 8PHE L 475
VAL L 409
ILE L 499
GLU L 460
None
0.79A17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		1nbq JUNCTIONAL ADHESION
MOLECULE 1
(Homo
sapiens)		4 / 8PHE A  55
TYR A  52
VAL A  31
GLU A 113
None
1.09A20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		2qc7 ENDOPLASMIC
RETICULUM PROTEIN
ERP29
(Homo
sapiens)		4 / 8PHE A  46
VAL A  91
ILE A  93
ASN A 101
None
0.96A20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		3ihp UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 5
(Homo
sapiens)		4 / 8PHE A 461
TYR A 568
VAL A 570
ILE A 827
None
1.10A17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		3kq0 ALPHA-1-ACID
GLYCOPROTEIN 1
(Homo
sapiens)		4 / 8PHE A  32
TYR A  37
VAL A  41
ILE A  44
None
1.08A19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		3pg7 NEUROFIBROMIN
(Homo
sapiens)		4 / 8PHE A1719
VAL A1736
ILE A1805
GLU A1794
None
1.06A21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		3pm0 CYTOCHROME P450 1B1
(Homo
sapiens)		4 / 8TYR A 214
VAL A 199
ARG A 213
ASN A 203
None
1.07A20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		5cmn LATROPHILIN-3
(Homo
sapiens)		4 / 8PHE E 314
VAL E 367
ILE E 364
ASN E 312
None
CA  E 401 (-4.8A)
None
CA  E 401 (-3.3A)
1.02A22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		5te1 ATP-CITRATE SYNTHASE
(Homo
sapiens)		4 / 8PHE A 493
VAL A 568
ILE A 591
GLU A 683
None
1.07A16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		5tet ATP-CITRATE SYNTHASE
(Homo
sapiens)		4 / 8PHE B 493
VAL B 568
ILE B 591
GLU B 683
None
1.05A19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		5udy ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 7
(Homo
sapiens)		4 / 8TYR A 194
VAL A  36
ILE A 243
GLU A 171
None
None
None
FUC  A 508 ( 4.3A)
1.00A20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		1xr0 FGFR SIGNALLING
ADAPTOR SNT-1
(Homo
sapiens)		4 / 7GLU B  44
ILE B  46
GLU B  39
VAL B  13
None
1.07A16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		1ygu LEUKOCYTE COMMON
ANTIGEN
(Homo
sapiens)		4 / 7GLU A 894
GLU A1167
TYR A 767
VAL A 722
None
0.80A20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		2h8r HEPATOCYTE NUCLEAR
FACTOR 1-BETA
(Homo
sapiens)		4 / 7GLU A 138
GLU A 178
HIS A 284
VAL A 278
None
0.87A20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		2ke9 CASKIN-2
(Homo
sapiens)		4 / 7ILE A 334
HIS A 325
VAL A 344
PHE A 337
None
1.10A12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		2nna MHC CLASS II ANTIGEN
(Homo
sapiens)		4 / 7GLU B  36
ILE B  31
VAL B  78
PHE B  11
None
1.03A19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		2wmo DEDICATOR OF
CYTOKINESIS PROTEIN
9
(Homo
sapiens)		4 / 7TYR A 155
HIS A 229
VAL A 158
PHE A 287
None
0.84A19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		2xss CGMP-SPECIFIC 3',
5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens)		4 / 7GLU A 390
GLU A 392
TYR A 409
VAL A 415
None
1.11A21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		3e4c CASPASE-1
(Homo
sapiens)		4 / 7ILE A 328
HIS A 356
VAL A 133
PHE A 231
None
1.01A23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		3odw RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 1
(Homo
sapiens)		4 / 7GLU A 428
TYR A 568
VAL A 588
PHE A 474
None
1.06A19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		3w1g DNA LIGASE 4
(Homo
sapiens)		4 / 7ILE A 315
TYR A 290
HIS A 282
PHE A 302
None
1.11A19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		4avx HEPATOCYTE GROWTH
FACTOR-REGULATED
TYROSINE KINASE
SUBSTRATE
(Homo
sapiens)		4 / 7GLU A   9
TYR A  44
VAL A  79
PHE A   8
None
EDO  A1234 (-4.1A)
None
None
1.10A18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		4f2a CHOLESTERYL ESTER
TRANSFER PROTEIN
(Homo
sapiens)		4 / 7ILE A 367
GLU A 365
VAL A 311
PHE A 363
2OB  A 606 (-4.7A)
None
None
None
1.07A20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		4f2a CHOLESTERYL ESTER
TRANSFER PROTEIN
(Homo
sapiens)		4 / 7ILE A 389
GLU A 365
VAL A 311
PHE A 363
None
0.98A20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		4nzr PGT135 HEAVY CHAIN
PROTEIN M TD
(Homo
sapiens;
Mycoplasma
genitalium)		4 / 7GLU M 427
ILE M 449
TYR H  32
HIS H  95
None
0.72A21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		4x0q DNA POLYMERASE THETA
(Homo
sapiens)		4 / 7GLU A2049
ILE A2053
HIS A2236
VAL A2232
None
None
None
GOL  A2602 (-4.5A)
0.94A16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		5fwm HEAT SHOCK PROTEIN
HSP 90 BETA
(Homo
sapiens)		4 / 7ILE A 441
TYR A 457
HIS A 458
VAL A 494
None
1.10A18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		5m9o STAPHYLOCOCCAL
NUCLEASE
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens)		4 / 7GLU A 751
HIS A 695
VAL A 698
PHE A 762
None
1.07A22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		5ojj UBIQUITIN-CONJUGATIN
G ENZYME E2 T
(Homo
sapiens)		4 / 7GLU A 131
TYR A  75
HIS A 150
PHE A 139
None
1.08A18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		5u4r VRC 315 53-1A09 FAB
HEAVY CHAIN
(Homo
sapiens)		4 / 7TYR A  32
HIS A  33
VAL A  78
PHE A  27
None
0.97A20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		5w21 FIBROBLAST GROWTH
FACTOR 23
(Homo
sapiens)		4 / 7ILE B  75
TYR B 127
HIS B 128
PHE B 157
None
1.06A12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		1kfu M-CALPAIN LARGE
SUBUNIT
(Homo
sapiens)		4 / 7PHE L 475
VAL L 409
ILE L 499
GLU L 460
None
0.75A17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		1lpb LIPASE
(Homo
sapiens)		4 / 7PHE B 386
TYR B 340
VAL B 342
ILE B 420
None
0.85A20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		1nbq JUNCTIONAL ADHESION
MOLECULE 1
(Homo
sapiens)		4 / 7PHE A  55
TYR A  52
VAL A  31
GLU A 113
None
1.14A20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		1q9p HIV-1 PROTEASE
(Homo
sapiens)		4 / 7TYR A  59
VAL A  75
ILE A  64
GLU A  35
None
1.09A16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		2ija ARYLAMINE
N-ACETYLTRANSFERASE
1
(Homo
sapiens)		4 / 7TYR A  94
VAL A  93
ILE A 106
GLU A 182
UNX  A 502 (-4.3A)
None
None
None
1.08A24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		3ihp UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 5
(Homo
sapiens)		4 / 7PHE A 461
TYR A 568
VAL A 570
ILE A 827
None
1.09A17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		3kq0 ALPHA-1-ACID
GLYCOPROTEIN 1
(Homo
sapiens)		4 / 7PHE A  32
TYR A  37
VAL A  41
ILE A  44
None
1.06A19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		3pm0 CYTOCHROME P450 1B1
(Homo
sapiens)		4 / 7TYR A 214
VAL A 199
ARG A 213
ASN A 203
None
1.12A20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		4hpf POTASSIUM CHANNEL
SUBFAMILY U MEMBER 1
(Homo
sapiens)		4 / 7TYR A 917
ILE A 472
ASN A 471
GLU A 558
None
0.92A18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		4i8v CYTOCHROME P450 1A1
(Homo
sapiens)		4 / 7TYR A 207
VAL A 192
ARG A 206
ASN A 196
None
1.13A20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		4i8v CYTOCHROME P450 1A1
(Homo
sapiens)		4 / 7VAL A 192
ARG A 206
ASN A 196
GLU A 213
None
1.08A20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		4j1y COMPLEMENT C1S
SUBCOMPONENT
(Homo
sapiens)		4 / 7TYR A 468
ILE A 465
ASN A 466
GLU A 506
None
1.14A21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		5mc5 XAA-PRO DIPEPTIDASE
(Homo
sapiens)		4 / 7PHE A  96
TYR A  83
VAL A  85
ILE A  45
None
0.66A14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		5te1 ATP-CITRATE SYNTHASE
(Homo
sapiens)		4 / 7PHE A 493
VAL A 568
ILE A 591
GLU A 683
None
1.07A16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		5tet ATP-CITRATE SYNTHASE
(Homo
sapiens)		4 / 7PHE B 493
VAL B 568
ILE B 591
GLU B 683
None
1.08A19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		6caa ELECTROGENIC SODIUM
BICARBONATE
COTRANSPORTER 1
(Homo
sapiens)		4 / 7PHE A 865
TYR A 862
VAL A 864
ILE A 692
None
1.09A13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		1cdz PROTEIN (DNA-REPAIR
PROTEIN XRCC1)
(Homo
sapiens)		4 / 6GLU A  21
PHE A  17
HIS A  87
VAL A  44
None
1.21A14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		1y7n AMYLOID BETA A4
PRECURSOR
PROTEIN-BINDING
FAMILY A MEMBER 1
(Homo
sapiens)		4 / 6ILE A  43
PHE A  28
HIS A  83
VAL A  12
None
1.19A13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		2ee6 FILAMIN-B
(Homo
sapiens)		4 / 6ILE A  56
PHE A  58
HIS A  88
VAL A  14
None
1.19A15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		2iik 3-KETOACYL-COA
THIOLASE,
PEROXISOMAL
(Homo
sapiens)		4 / 6GLU A 223
ILE A 389
PHE A 220
HIS A 378
None
1.16A20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		3p8c NCK-ASSOCIATED
PROTEIN 1
(Homo
sapiens)		4 / 6ILE B 733
PHE B 825
HIS B 858
VAL B 912
None
1.15A13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		3p8c NCK-ASSOCIATED
PROTEIN 1
(Homo
sapiens)		4 / 6ILE B 733
PHE B 825
TYR B 792
VAL B 912
None
1.21A13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		4nzr PGT135 HEAVY CHAIN
PROTEIN M TD
(Homo
sapiens;
Mycoplasma
genitalium)		4 / 6GLU M 427
ILE M 449
TYR H  32
HIS H  95
None
0.80A21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		4x0q DNA POLYMERASE THETA
(Homo
sapiens)		4 / 6GLU A2049
ILE A2053
HIS A2236
VAL A2232
None
None
None
GOL  A2602 (-4.5A)
0.97A16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		5fi0 PHOSPHATIDYLINOSITOL
3,4,5-TRISPHOSPHATE-
DEPENDENT RAC
EXCHANGER 1
PROTEIN,PHOSPHATIDYL
INOSITOL
3,4,5-TRISPHOSPHATE-
DEPENDENT RAC
EXCHANGER 1 PROTEIN
(Homo
sapiens)		4 / 6ILE A 331
PHE A 291
HIS A 349
VAL A 355
None
1.07A20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		5fwm HEAT SHOCK PROTEIN
HSP 90 BETA
(Homo
sapiens)		4 / 6ILE A 441
TYR A 457
HIS A 458
VAL A 494
None
1.15A18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		5hmp UNCONVENTIONAL
MYOSIN-VC
(Homo
sapiens)		4 / 6GLU A 457
ILE A 494
PHE A 551
HIS A 466
None
1.00A17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens)		4 / 6ILE A 564
PHE A 198
TYR A 301
HIS A 232
None
1.22A19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens)		4 / 6GLU A 410
TYR A 298
HIS A 297
VAL A 284
None
1.23A16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		5kz5 CYSTEINE
DESULFURASE,
MITOCHONDRIAL
(Homo
sapiens)		4 / 6GLU 1 416
TYR 1 317
HIS 1 319
VAL 1 310
None
0.94A20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		5l3x NEGATIVE ELONGATION
FACTOR C/D
(Homo
sapiens)		4 / 6PHE B 333
TYR B 356
HIS B 354
VAL B 390
None
1.10A21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		5of4 GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT 2
(Homo
sapiens)		4 / 6ILE E 170
PHE E  91
TYR E 228
HIS E 227
None
1.06A21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		5xjy ATP-BINDING CASSETTE
SUB-FAMILY A MEMBER
1
(Homo
sapiens)		4 / 6ILE A1677
PHE A1675
HIS A1686
VAL A1693
None
1.17A9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_J_ZPCJ1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		1hnf CD2
(Homo
sapiens)		4 / 8PHE A  98
TYR A  81
VAL A  83
ILE A  33
None
NA  A 629 (-4.7A)
None
None
0.86A17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_J_ZPCJ1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		1kfu M-CALPAIN LARGE
SUBUNIT
(Homo
sapiens)		4 / 8PHE L 475
VAL L 409
ILE L 499
GLU L 460
None
0.79A17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_J_ZPCJ1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		1lpb LIPASE
(Homo
sapiens)		4 / 8PHE B 386
TYR B 340
VAL B 342
ILE B 420
None
0.89A20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_J_ZPCJ1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		1nbq JUNCTIONAL ADHESION
MOLECULE 1
(Homo
sapiens)		4 / 8PHE A  55
TYR A  52
VAL A  31
GLU A 113
None
1.09A20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_J_ZPCJ1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		2ija ARYLAMINE
N-ACETYLTRANSFERASE
1
(Homo
sapiens)		4 / 8TYR A  94
VAL A  93
ILE A 106
GLU A 182
UNX  A 502 (-4.3A)
None
None
None
1.04A24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_J_ZPCJ1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		2qc7 ENDOPLASMIC
RETICULUM PROTEIN
ERP29
(Homo
sapiens)		4 / 8PHE A  46
VAL A  91
ILE A  93
ASN A 101
None
1.05A20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_J_ZPCJ1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		3ihp UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 5
(Homo
sapiens)		4 / 8PHE A 461
TYR A 568
VAL A 570
ILE A 827
None
1.09A17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_J_ZPCJ1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		3kq0 ALPHA-1-ACID
GLYCOPROTEIN 1
(Homo
sapiens)		4 / 8PHE A  32
TYR A  37
VAL A  41
ILE A  44
None
1.00A19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_J_ZPCJ1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		4hpf POTASSIUM CHANNEL
SUBFAMILY U MEMBER 1
(Homo
sapiens)		4 / 8TYR A 917
ILE A 472
ASN A 471
GLU A 558
None
1.09A18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_J_ZPCJ1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		5mc5 XAA-PRO DIPEPTIDASE
(Homo
sapiens)		4 / 8PHE A  96
TYR A  83
VAL A  85
ILE A  45
None
0.64A14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_J_ZPCJ1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		5te1 ATP-CITRATE SYNTHASE
(Homo
sapiens)		4 / 8PHE A 493
VAL A 568
ILE A 591
GLU A 683
None
1.04A16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_J_ZPCJ1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		5tet ATP-CITRATE SYNTHASE
(Homo
sapiens)		4 / 8PHE B 493
VAL B 568
ILE B 591
GLU B 683
None
1.05A19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_J_ZPCJ1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		1l9x GAMMA-GLUTAMYL
HYDROLASE
(Homo
sapiens)		4 / 5GLU A 227
GLU A 222
PHE A 287
HIS A 171
None
1.44A20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_J_ZPCJ1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		2xze CHARGED
MULTIVESICULAR BODY
PROTEIN 3
STAM-BINDING PROTEIN
(Homo
sapiens)		4 / 5GLU Q 206
GLU Q 207
TYR A  80
HIS A  77
None
1.30A8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_J_ZPCJ1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		5hpk E3 UBIQUITIN-PROTEIN
LIGASE NEDD4-LIKE
UBIQUITIN VARIANT
NL.1
(Homo
sapiens)		4 / 5GLU B  77
GLU A 609
TYR A 689
HIS A 686
None
1.43A14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_J_ZPCJ1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5
(Homo
sapiens)		4 / 5GLU A 746
GLU A 710
PHE A 744
TYR A 675
None
1.43A13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_J_ZPCJ1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)
(Homo
sapiens)		4 / 5GLU A1376
PHE A1383
TYR A1485
HIS A1482
None
1.49A0.00