POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		1x3a SYNAPSE ASSOCIATED
PROTEIN 1
(Homo
sapiens)		5 / 12SER A  22
VAL A  51
SER A  60
PHE A  28
VAL A  84
None
1.12A15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		2m6b FULL-LENGTH
TRANSMEMBRANE
DOMAINS OF HUMAN
GLYCINE RECEPTOR
ALPHA1 SUBUNIT
(Homo
sapiens)		5 / 12LEU A 261
VAL A 260
GLY A 256
PHE A 293
VAL A 294
None
1.41A18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		2qqm NEUROPILIN-1
(Homo
sapiens)		5 / 12SER A 244
LEU A 441
GLY A 241
SER A 238
VAL A 220
None
1.42A21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		3e0j DNA POLYMERASE
SUBUNIT DELTA-2
(Homo
sapiens)		5 / 12VAL A 428
GLY A 405
SER A 345
PHE A 403
VAL A 241
None
1.44A23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		3ggr CELL CYCLE
CHECKPOINT CONTROL
PROTEIN RAD9A
(Homo
sapiens)		5 / 12SER A 237
VAL A 176
GLY A 171
PHE A 222
VAL A 151
None
1.26A24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		3gzd SELENOCYSTEINE LYASE
(Homo
sapiens)		5 / 12LEU C 253
VAL C 245
GLY C 249
SER C 210
VAL C 106
None
1.45A20.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		3pbl D(3) DOPAMINE
RECEPTOR, LYSOZYME
CHIMERA
(Homo
sapiens;
Escherichia
virus
T4)		6 / 12VAL A 189
SER A 196
PHE A 338
TRP A 342
PHE A 345
PHE A 346
ETQ  A1200 ( 4.2A)
ETQ  A1200 ( 4.6A)
None
None
ETQ  A1200 (-4.4A)
ETQ  A1200 ( 4.5A)
0.59A30.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		3pds FUSION PROTEIN
BETA-2 ADRENERGIC
RECEPTOR/LYSOZYME
(Homo
sapiens;
Escherichia
virus
T4)		5 / 12PHE A 282
TRP A 286
PHE A 289
PHE A 290
ASN A 293
None
None
ERC  A1201 (-4.5A)
ERC  A1201 (-4.8A)
ERC  A1201 (-3.5A)
0.51A30.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		3pds FUSION PROTEIN
BETA-2 ADRENERGIC
RECEPTOR/LYSOZYME
(Homo
sapiens;
Escherichia
virus
T4)		5 / 12TRP A 109
PHE A 282
TRP A 286
PHE A 289
PHE A 290
None
None
None
ERC  A1201 (-4.5A)
ERC  A1201 (-4.8A)
0.50A30.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		3pds FUSION PROTEIN
BETA-2 ADRENERGIC
RECEPTOR/LYSOZYME
(Homo
sapiens;
Escherichia
virus
T4)		5 / 12TRP A 109
SER A 207
PHE A 282
TRP A 286
PHE A 289
None
ERC  A1201 (-2.7A)
None
None
ERC  A1201 (-4.5A)
0.74A30.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		3rze HISTAMINE H1
RECEPTOR, LYSOZYME
CHIMERA
(Homo
sapiens;
Escherichia
virus
T4)		5 / 12TRP A 103
SER A 111
PHE A 424
TRP A 428
PHE A 432
None
5EH  A1200 ( 3.7A)
None
5EH  A1200 ( 3.4A)
5EH  A1200 ( 4.3A)
0.65A28.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		4gbr BETA-2 ADRENERGIC
RECEPTOR
(Homo
sapiens)		7 / 12TRP A 109
SER A 207
PHE A 254
TRP A 258
PHE A 261
PHE A 262
ASN A 265
None
CAU  A 500 (-4.1A)
None
None
CAU  A 500 (-4.2A)
CAU  A 500 (-4.6A)
CAU  A 500 (-3.4A)
0.97A29.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		4ib4 CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens)		6 / 12PHE A 333
TRP A 337
PHE A 340
PHE A 341
ASN A 344
VAL A 366
None
None
ERM  A2001 (-4.3A)
None
ERM  A2001 (-4.3A)
ERM  A2001 ( 4.2A)
0.72A62.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		4ib4 CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens)		7 / 12SER A 139
GLY A 221
TRP A 337
PHE A 340
PHE A 341
ASN A 344
VAL A 366
ERM  A2001 (-3.6A)
ERM  A2001 ( 4.3A)
None
ERM  A2001 (-4.3A)
None
ERM  A2001 (-4.3A)
ERM  A2001 ( 4.2A)
0.78A62.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		4ib4 CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens)		7 / 12TRP A 131
SER A 139
GLY A 221
PHE A 340
PHE A 341
ASN A 344
VAL A 366
None
ERM  A2001 (-3.6A)
ERM  A2001 ( 4.3A)
ERM  A2001 (-4.3A)
None
ERM  A2001 (-4.3A)
ERM  A2001 ( 4.2A)
0.82A62.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		4ib4 CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens)		5 / 12TRP A 131
SER A 139
LEU A 209
PHE A 340
VAL A 366
None
ERM  A2001 (-3.6A)
ERM  A2001 (-3.7A)
ERM  A2001 (-4.3A)
ERM  A2001 ( 4.2A)
1.04A62.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1
(Homo
sapiens)		5 / 12LEU A 581
VAL A 616
SER A 619
PHE A 608
VAL A 606
None
1.37A20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		5w4x UDP-GLUCOSE
6-DEHYDROGENASE
(Homo
sapiens)		5 / 12LEU A 163
VAL A  15
GLY A  17
SER A  21
VAL A 178
None
1.44A22.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		5wiv D(4) DOPAMINE
RECEPTOR, SOLUBLE
CYTOCHROME B562
CHIMERA
(Escherichia
coli;
Homo
sapiens)		7 / 12LEU A 187
VAL A 193
SER A 200
PHE A 403
TRP A 407
PHE A 410
PHE A 411
AQD  A1201 (-4.5A)
AQD  A1201 (-3.9A)
AQD  A1201 (-3.6A)
None
None
AQD  A1201 (-4.7A)
AQD  A1201 (-4.6A)
0.67A44.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		5xjy ATP-BINDING CASSETTE
SUB-FAMILY A MEMBER
1
(Homo
sapiens)		5 / 12LEU A 722
SER A 637
PHE A 632
PHE A  36
PHE A 643
None
1.44A10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens)		7 / 12TRP A 130
SER A 138
LEU A 209
VAL A 215
GLY A 218
PHE A 320
TRP A 324
None
E2J  A1201 (-3.2A)
None
E2J  A1201 (-4.6A)
E2J  A1201 (-3.1A)
E2J  A1201 (-4.4A)
E2J  A1201 ( 3.7A)
0.87Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens)		9 / 12TRP A 130
SER A 138
LEU A 209
VAL A 215
PHE A 320
TRP A 324
PHE A 327
PHE A 328
VAL A 354
None
E2J  A1201 (-3.2A)
None
E2J  A1201 (-4.6A)
E2J  A1201 (-4.4A)
E2J  A1201 ( 3.7A)
E2J  A1201 (-4.6A)
E2J  A1201 (-4.4A)
E2J  A1201 (-4.6A)
0.78Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens)		7 / 12TRP A 130
SER A 138
VAL A 215
GLY A 218
PHE A 320
TRP A 324
ASN A 331
None
E2J  A1201 (-3.2A)
E2J  A1201 (-4.6A)
E2J  A1201 (-3.1A)
E2J  A1201 (-4.4A)
E2J  A1201 ( 3.7A)
None
1.00Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens)		9 / 12TRP A 130
SER A 138
VAL A 215
PHE A 320
TRP A 324
PHE A 327
PHE A 328
ASN A 331
VAL A 354
None
E2J  A1201 (-3.2A)
E2J  A1201 (-4.6A)
E2J  A1201 (-4.4A)
E2J  A1201 ( 3.7A)
E2J  A1201 (-4.6A)
E2J  A1201 (-4.4A)
None
E2J  A1201 (-4.6A)
0.80Aundetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6cm4 D(2) DOPAMINE
RECEPTOR, ENDOLYSIN
CHIMERA
(Homo
sapiens;
Escherichia
virus
T4)		6 / 12VAL A 190
SER A 197
PHE A 382
TRP A 386
PHE A 389
PHE A 390
None
8NU  A2001 ( 3.6A)
8NU  A2001 ( 4.7A)
8NU  A2001 ( 3.8A)
8NU  A2001 ( 4.5A)
8NU  A2001 ( 4.8A)
0.47A33.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		1ad0 ANTIBODY A5B7 (HEAVY
CHAIN)
(Homo
sapiens)		6 / 12VAL B 183
THR B 135
LEU B 159
VAL B 163
GLY B 162
VAL B 210
None
1.50A19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		1x3a SYNAPSE ASSOCIATED
PROTEIN 1
(Homo
sapiens)		5 / 12SER A  22
VAL A  51
SER A  60
PHE A  28
VAL A  84
None
1.13A15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		1xnt PROTEIN (DNA-REPAIR
PROTEIN XRCC1)
(Homo
sapiens)		5 / 12VAL A  46
VAL A  72
GLY A  73
PHE A 149
VAL A 147
None
1.08A19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		2f8a GLUTATHIONE
PEROXIDASE 1
(Homo
sapiens)		5 / 12VAL A  51
THR A  55
VAL A  97
GLY A 100
PHE A 107
None
0.99A17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		3bx8 ENGINEERED HUMAN
LIPOCALIN 2
(Homo
sapiens)		5 / 12VAL A 120
VAL A  33
GLY A  35
PHE A 123
VAL A 108
None
None
None
1PE  A 179 (-3.8A)
None
1.20A18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		3hc4 IMMUNOGLOBULIN IGG1
FAB, HEAVY CHAIN
(Homo
sapiens)		6 / 12VAL H 187
THR H 138
LEU H 162
VAL H 166
GLY H 165
VAL H 214
None
1.49A17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens)		5 / 12VAL A  46
VAL A  72
GLY A  73
PHE A 149
VAL A 147
None
1.10A16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		3oaz FAB 2G12, HEAVY
CHAIN
(Homo
sapiens)		6 / 12VAL H 193
THR H 137
LEU H 166
VAL H 171
GLY H 169
VAL H 225
None
1.50A18.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		3pbl D(3) DOPAMINE
RECEPTOR, LYSOZYME
CHIMERA
(Homo
sapiens;
Escherichia
virus
T4)		8 / 12VAL A 111
THR A 115
VAL A 189
SER A 196
PHE A 338
TRP A 342
PHE A 345
PHE A 346
ETQ  A1200 (-3.4A)
None
ETQ  A1200 ( 4.2A)
ETQ  A1200 ( 4.6A)
None
None
ETQ  A1200 (-4.4A)
ETQ  A1200 ( 4.5A)
0.62A30.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		3pds FUSION PROTEIN
BETA-2 ADRENERGIC
RECEPTOR/LYSOZYME
(Homo
sapiens;
Escherichia
virus
T4)		6 / 12VAL A 114
THR A 118
PHE A 282
TRP A 286
PHE A 289
PHE A 290
ERC  A1201 (-3.8A)
None
None
None
ERC  A1201 (-4.5A)
ERC  A1201 (-4.8A)
0.38A30.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		3pds FUSION PROTEIN
BETA-2 ADRENERGIC
RECEPTOR/LYSOZYME
(Homo
sapiens;
Escherichia
virus
T4)		6 / 12VAL A 114
THR A 118
SER A 207
PHE A 282
TRP A 286
PHE A 289
ERC  A1201 (-3.8A)
None
ERC  A1201 (-2.7A)
None
None
ERC  A1201 (-4.5A)
0.62A30.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		3rze HISTAMINE H1
RECEPTOR, LYSOZYME
CHIMERA
(Homo
sapiens;
Escherichia
virus
T4)		5 / 12SER A 111
THR A 112
PHE A 424
TRP A 428
PHE A 432
5EH  A1200 ( 3.7A)
D7V  A1201 ( 4.0A)
None
5EH  A1200 ( 3.4A)
5EH  A1200 ( 4.3A)
0.43A28.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		4gbr BETA-2 ADRENERGIC
RECEPTOR
(Homo
sapiens)		7 / 12VAL A 114
THR A 118
SER A 207
PHE A 254
TRP A 258
PHE A 261
PHE A 262
CAU  A 500 (-3.5A)
CAU  A 500 ( 4.7A)
CAU  A 500 (-4.1A)
None
None
CAU  A 500 (-4.2A)
CAU  A 500 (-4.6A)
0.63A29.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		4gow POTASSIUM
VOLTAGE-GATED
CHANNEL SUBFAMILY
KQT MEMBER 4
CALMODULIN
(Homo
sapiens;
Homo
sapiens)		5 / 12VAL A 533
THR A 532
LEU D 112
PHE D  92
VAL D  91
VAL  A 533 ( 0.6A)
THR  A 532 ( 0.8A)
LEU  D 112 ( 0.6A)
PHE  D  92 ( 1.3A)
VAL  D  91 ( 0.6A)
1.08A14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		4hwe FAB HEAVY CHAIN
(Homo
sapiens)		6 / 12VAL H 190
THR H 141
LEU H 165
VAL H 169
GLY H 168
VAL H 217
None
None
GOL  H 308 ( 4.0A)
None
None
None
1.48A20.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		4ib4 CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens)		5 / 12PHE A 333
TRP A 337
PHE A 340
PHE A 341
VAL A 366
None
None
ERM  A2001 (-4.3A)
None
ERM  A2001 ( 4.2A)
0.67A62.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		4ib4 CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens)		5 / 12THR A 140
PHE A 333
TRP A 337
PHE A 341
VAL A 366
ERM  A2001 (-3.9A)
None
None
None
ERM  A2001 ( 4.2A)
1.11A62.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		4ib4 CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens)		7 / 12VAL A 136
SER A 139
GLY A 221
TRP A 337
PHE A 340
PHE A 341
VAL A 366
ERM  A2001 (-3.8A)
ERM  A2001 (-3.6A)
ERM  A2001 ( 4.3A)
None
ERM  A2001 (-4.3A)
None
ERM  A2001 ( 4.2A)
0.75A62.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		4ib4 CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens)		5 / 12VAL A 136
SER A 139
LEU A 209
PHE A 340
VAL A 366
ERM  A2001 (-3.8A)
ERM  A2001 (-3.6A)
ERM  A2001 (-3.7A)
ERM  A2001 (-4.3A)
ERM  A2001 ( 4.2A)
0.98A62.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		4ib4 CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens)		7 / 12VAL A 136
SER A 139
THR A 140
GLY A 221
TRP A 337
PHE A 341
VAL A 366
ERM  A2001 (-3.8A)
ERM  A2001 (-3.6A)
ERM  A2001 (-3.9A)
ERM  A2001 ( 4.3A)
None
None
ERM  A2001 ( 4.2A)
0.88A62.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		4ib4 CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens)		5 / 12VAL A 136
SER A 139
THR A 140
LEU A 209
PHE A 340
ERM  A2001 (-3.8A)
ERM  A2001 (-3.6A)
ERM  A2001 (-3.9A)
ERM  A2001 (-3.7A)
ERM  A2001 (-4.3A)
0.92A62.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		4ib4 CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens)		5 / 12VAL A 136
SER A 139
THR A 140
LEU A 209
VAL A 366
ERM  A2001 (-3.8A)
ERM  A2001 (-3.6A)
ERM  A2001 (-3.9A)
ERM  A2001 (-3.7A)
ERM  A2001 ( 4.2A)
0.98A62.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		4lde LYSOZYME, BETA-2
ADRENERGIC RECEPTOR
(Homo
sapiens;
Escherichia
virus
T4)		5 / 12VAL A1114
THR A1118
TRP A1286
PHE A1289
PHE A1290
P0G  A1401 (-3.7A)
None
None
P0G  A1401 ( 4.7A)
P0G  A1401 ( 4.9A)
0.64A24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		4lly MUTATED PERTUZUMAB
FAB HEAVY CHAIN
(Homo
sapiens)		6 / 12VAL A 190
THR A 141
LEU A 165
VAL A 169
GLY A 168
VAL A 217
None
1.48A21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		4uta BROADLY NEUTRALIZING
HUMAN ANTIBODY EDE1
C8 HEAVY CHAIN
(Homo
sapiens)		6 / 12VAL H 193
THR H 144
LEU H 168
VAL H 172
GLY H 171
VAL H 220
None
1.49A18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		5ies VRC01CHUGL2 FAB
HEAVY CHAIN
(Homo
sapiens)		6 / 12VAL H 184
THR H 135
LEU H 159
VAL H 163
GLY H 162
VAL H 211
None
1.50A18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		5kw9 IGA(VH)-IGG(CH)
HEAVY CHAIN FAB
FRAGMENT
(Homo
sapiens)		6 / 12VAL H 195
THR H 146
LEU H 170
VAL H 174
GLY H 173
VAL H 222
None
1.46A21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		5n4g HEAVY CHAIN
(Homo
sapiens)		6 / 12VAL H 186
THR H 137
LEU H 161
VAL H 165
GLY H 164
VAL H 213
None
1.49A19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		5u3j DH511.1 HEAVY CHAIN
(Homo
sapiens)		6 / 12VAL H 184
THR H 135
LEU H 159
VAL H 163
GLY H 162
VAL H 211
None
1.48A21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		5u3n DH511.12P FAB HEAVY
CHAIN
(Homo
sapiens)		6 / 12VAL H 184
THR H 135
LEU H 159
VAL H 163
GLY H 162
VAL H 211
None
1.50A20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		5v54 5-HYDROXYTRYPTAMINE
RECEPTOR 1B,OB-1
FUSED 5-HT1B
RECEPTOR,5-HYDROXYTR
YPTAMINE RECEPTOR 1B
(Spodoptera
frugiperda;
Homo
sapiens)		5 / 12THR A 134
PHE A 323
TRP A 327
PHE A 330
PHE A 331
89F  A1201 (-4.2A)
None
89F  A1201 (-3.6A)
89F  A1201 (-4.1A)
89F  A1201 (-4.6A)
0.93Aundetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		5wiv D(4) DOPAMINE
RECEPTOR, SOLUBLE
CYTOCHROME B562
CHIMERA
(Escherichia
coli;
Homo
sapiens)		9 / 12VAL A 116
THR A 120
LEU A 187
VAL A 193
SER A 200
PHE A 403
TRP A 407
PHE A 410
PHE A 411
AQD  A1201 ( 3.9A)
AQD  A1201 (-4.4A)
AQD  A1201 (-4.5A)
AQD  A1201 (-3.9A)
AQD  A1201 (-3.6A)
None
None
AQD  A1201 (-4.7A)
AQD  A1201 (-4.6A)
0.83A44.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens)		10 / 12VAL A 135
SER A 138
THR A 139
LEU A 209
VAL A 215
GLY A 218
PHE A 320
TRP A 324
PHE A 327
VAL A 354
E2J  A1201 (-3.8A)
E2J  A1201 (-3.2A)
E2J  A1201 (-4.3A)
None
E2J  A1201 (-4.6A)
E2J  A1201 (-3.1A)
E2J  A1201 (-4.4A)
E2J  A1201 ( 3.7A)
E2J  A1201 (-4.6A)
E2J  A1201 (-4.6A)
0.85Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens)		10 / 12VAL A 135
SER A 138
THR A 139
LEU A 209
VAL A 215
PHE A 320
TRP A 324
PHE A 327
PHE A 328
VAL A 354
E2J  A1201 (-3.8A)
E2J  A1201 (-3.2A)
E2J  A1201 (-4.3A)
None
E2J  A1201 (-4.6A)
E2J  A1201 (-4.4A)
E2J  A1201 ( 3.7A)
E2J  A1201 (-4.6A)
E2J  A1201 (-4.4A)
E2J  A1201 (-4.6A)
0.76Aundetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		6cm4 D(2) DOPAMINE
RECEPTOR, ENDOLYSIN
CHIMERA
(Homo
sapiens;
Escherichia
virus
T4)		8 / 12VAL A 115
THR A 119
VAL A 190
SER A 197
PHE A 382
TRP A 386
PHE A 389
PHE A 390
8NU  A2001 ( 3.5A)
8NU  A2001 ( 4.4A)
None
8NU  A2001 ( 3.6A)
8NU  A2001 ( 4.7A)
8NU  A2001 ( 3.8A)
8NU  A2001 ( 4.5A)
8NU  A2001 ( 4.8A)
0.55A33.18