POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4G_A_ZMRA466_1
(NEURAMINIDASE)		2f28 SIALIDASE 2
(Homo
sapiens)		5 / 12ARG A  21
GLU A 218
ARG A 237
ARG A 304
TYR A 334
None
0.42A21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4G_A_ZMRA466_1
(NEURAMINIDASE)		5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens)		5 / 12ARG A 929
ASP A 914
ARG A 814
GLU A1034
ARG A1039
None
None
EDO  A1603 (-3.9A)
EDO  A1603 (-2.7A)
EDO  A1603 ( 3.8A)
1.30A13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4G_B_ZMRB466_1
(NEURAMINIDASE)		2f28 SIALIDASE 2
(Homo
sapiens)		5 / 12ARG A  21
GLU A 218
ARG A 237
ARG A 304
TYR A 334
None
0.44A21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4G_B_ZMRB466_1
(NEURAMINIDASE)		5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens)		5 / 12GLU A 434
ARG A 509
ARG A 388
ALA A 412
GLU A 423
None
1.26A19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4G_B_ZMRB466_1
(NEURAMINIDASE)		6fel 14-3-3 PROTEIN GAMMA
(Homo
sapiens)		5 / 12ARG A  61
GLU A 185
ARG A 132
ASN A 178
ARG A  57
None
1.20A10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4G_B_ZMRB466_2
(NEURAMINIDASE)		1nd7 WW DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens)		3 / 3ASP A 712
ARG A 711
ILE A 693
None
0.68A21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4G_B_ZMRB466_2
(NEURAMINIDASE)		1p22 F-BOX/WD-REPEAT
PROTEIN 1A
(Homo
sapiens)		3 / 3ASP A 545
ARG A 254
ILE A 246
None
0.87A21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4G_B_ZMRB466_2
(NEURAMINIDASE)		1s4y ACTIVIN RECEPTOR
TYPE IIB PRECURSOR
INHIBIN BETA A CHAIN
(Homo
sapiens;
Mus
musculus)		3 / 3ASP A  58
ARG B  87
ILE B 109
None
0.80A13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4G_B_ZMRB466_2
(NEURAMINIDASE)		1ya0 SMG-7 TRANSCRIPT
VARIANT 2
(Homo
sapiens)		3 / 3ASP A 160
ARG A 163
ILE A 194
None
SO4  A 498 (-3.1A)
None
0.81A19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4G_B_ZMRB466_2
(NEURAMINIDASE)		3qq8 TRANSITIONAL
ENDOPLASMIC
RETICULUM ATPASE
(Homo
sapiens)		3 / 3ASP A  29
ARG A  83
ILE A  32
None
0.76A18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4G_B_ZMRB466_2
(NEURAMINIDASE)		5vhi 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT 2
(Homo
sapiens)		3 / 3ASP f 784
ARG f 785
ILE f 660
None
0.88A17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4G_B_ZMRB466_2
(NEURAMINIDASE)		5x4l TRANSITIONAL
ENDOPLASMIC
RETICULUM ATPASE
(Homo
sapiens)		3 / 3ASP A  29
ARG A  83
ILE A  32
None
0.70A18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NNC_A_ZMRA479_1
(NEURAMINIDASE N9)		2f28 SIALIDASE 2
(Homo
sapiens)		5 / 12ARG A  21
GLU A 218
ARG A 237
ARG A 304
TYR A 334
None
0.54A22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NNC_A_ZMRA479_1
(NEURAMINIDASE N9)		4mel UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 11
(Homo
sapiens)		5 / 12GLU A  71
GLU A  50
GLU A  43
ARG A  49
TYR A  67
None
1.34A19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NNC_A_ZMRA479_1
(NEURAMINIDASE N9)		6eih 14-3-3 PROTEIN
EPSILON
(Homo
sapiens)		5 / 12ARG A  61
GLU A 183
ARG A 130
ASN A 176
ARG A  57
None
0.93A11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NNC_A_ZMRA479_1
(NEURAMINIDASE N9)		6fel 14-3-3 PROTEIN GAMMA
(Homo
sapiens)		5 / 12ARG A  61
GLU A 185
ARG A 132
ASN A 178
ARG A  57
None
1.11A11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V3E_A_ZMRA1200_1
(HEMAGGLUTININ-NEURAM
INIDASE GLYCOPROTEIN)		2f28 SIALIDASE 2
(Homo
sapiens)		5 / 10ARG A  21
TYR A 179
GLU A 218
ARG A 237
TYR A 334
None
1.06A18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V3E_A_ZMRA1200_1
(HEMAGGLUTININ-NEURAM
INIDASE GLYCOPROTEIN)		5nkp KELCH-LIKE PROTEIN 3
(Homo
sapiens)		5 / 10ARG A 339
THR A 386
TYR A 449
ARG A 528
TYR A 577
 CL  A 602 (-4.2A)
CL  A 602 (-3.8A)
None
None
None
1.02A21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V3E_B_ZMRB2200_1
(HEMAGGLUTININ-NEURAM
INIDASE GLYCOPROTEIN)		2f28 SIALIDASE 2
(Homo
sapiens)		5 / 10ARG A  21
TYR A 179
GLU A 218
ARG A 237
ARG A 304
None
0.76A18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1477_1
(NEURAMINIDASE)		2f28 SIALIDASE 2
(Homo
sapiens)		5 / 12ARG A  21
GLU A 218
ARG A 237
ARG A 304
TYR A 334
None
0.44A21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1477_1
(NEURAMINIDASE)		4mel UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 11
(Homo
sapiens)		5 / 12GLU A  71
GLU A  50
GLU A  43
ARG A  49
TYR A  67
None
1.32A18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1477_1
(NEURAMINIDASE)		6eih 14-3-3 PROTEIN
EPSILON
(Homo
sapiens)		5 / 12ARG A  61
GLU A 183
ARG A 130
ASN A 176
ARG A  57
None
0.96A14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1477_1
(NEURAMINIDASE)		6fel 14-3-3 PROTEIN GAMMA
(Homo
sapiens)		5 / 12ARG A  61
GLU A 185
ARG A 132
ASN A 178
ARG A  57
None
1.13A11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1478_1
(NEURAMINIDASE)		1fs2 SKP2
(Homo
sapiens)		4 / 7SER A 303
ASP A 331
SER A 276
ASN A 301
None
1.15A21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1478_1
(NEURAMINIDASE)		2ass S-PHASE
KINASE-ASSOCIATED
PROTEIN 2
(Homo
sapiens)		4 / 7SER B2291
ASP B2319
SER B2264
ASN B2289
None
1.09A20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1478_1
(NEURAMINIDASE)		2ass S-PHASE
KINASE-ASSOCIATED
PROTEIN 2
(Homo
sapiens)		4 / 7SER B2318
ASP B2316
SER B2341
SER B2343
None
1.06A20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1478_1
(NEURAMINIDASE)		2nmp CYSTATHIONINE
GAMMA-LYASE
(Homo
sapiens)		4 / 7SER A 226
SER A 206
ASN A 188
GLN A 196
None
1.12A20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1478_1
(NEURAMINIDASE)		2z7x TOLL-LIKE RECEPTOR
1, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens)		4 / 7SER B 431
SER B 432
SER B 406
ASN B 429
NAG  A 831 (-3.6A)
NAG  A 833 ( 3.9A)
NAG  A 831 (-3.0A)
NAG  A 831 (-1.8A)
1.06A20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1478_1
(NEURAMINIDASE)		2z7x TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens)		4 / 7SER A 444
SER A 445
SER A 421
ASN A 442
NAG  A 921 ( 4.4A)
None
NAG  A 921 (-2.5A)
NAG  A 921 (-1.8A)
0.96A21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1478_1
(NEURAMINIDASE)		3nvq SEMAPHORIN-7A
(Homo
sapiens)		4 / 7SER A  85
ASP A  99
SER A  86
SER A  84
None
1.14A21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1478_1
(NEURAMINIDASE)		3u1s FAB PGT145 HEAVY
CHAIN
(Homo
sapiens)		4 / 7SER H  76
ASP H  72
SER H  73
ASN H  27
None
1.13A19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1478_1
(NEURAMINIDASE)		4gos V-SET
DOMAIN-CONTAINING
T-CELL ACTIVATION
INHIBITOR 1
(Homo
sapiens)		4 / 7SER A  55
SER A 114
ASN A 112
GLN A 107
NAG  A 202 ( 4.5A)
NAG  A 201 (-3.2A)
NAG  A 201 (-1.9A)
NAG  A 201 (-4.7A)
1.06A15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1478_1
(NEURAMINIDASE)		4gwn MEPRIN A SUBUNIT
BETA
(Homo
sapiens)		4 / 7SER A 242
ASP A 204
SER A 244
GLN A 151
None
1.08A21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1478_1
(NEURAMINIDASE)		4hcr PF-547659 HEAVY
CHAIN
(Homo
sapiens)		4 / 7SER H 104
ASP H 106
SER H 102
SER H 103
None
1.10A19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1478_1
(NEURAMINIDASE)		4kfz ANTI-LMO2 VH
(Homo
sapiens)		4 / 7SER C  56
SER C  57
SER C  52
ASN C  54
None
1.06A16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1478_1
(NEURAMINIDASE)		4nzu 13PL LIGHT CHAIN
(Homo
sapiens)		4 / 7SER H  55
SER H  56
SER H  52
ASN H  53
None
1.02A20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1478_1
(NEURAMINIDASE)		4rcj YTH
DOMAIN-CONTAINING
FAMILY PROTEIN 1
(Homo
sapiens)		4 / 7SER A 398
ASP A 400
SER A 396
TRP A 411
None
1.15A19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1478_1
(NEURAMINIDASE)		5a2e T-CELL
DIFFERENTIATION
ANTIGEN CD6
(Homo
sapiens)		4 / 7SER A  55
SER A  51
SER A  52
TRP A 238
None
1.04A20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1478_1
(NEURAMINIDASE)		5brr TISSUE-TYPE
PLASMINOGEN
ACTIVATOR
(Homo
sapiens)		4 / 7SER E 110
ASP E 110
SER E 110
GLN E  81
None
1.12A20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1478_1
(NEURAMINIDASE)		5hdh TOLL-LIKE RECEPTOR 8
(Homo
sapiens)		4 / 7SER A  71
ASP A  72
SER A  50
ASN A  93
None
1.15A17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1478_1
(NEURAMINIDASE)		5tet ATP-CITRATE SYNTHASE
(Homo
sapiens)		4 / 7SER B 574
SER B 577
GLN B 505
TRP B 502
None
1.11A22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1478_1
(NEURAMINIDASE)		5wve APOPTOTIC
PROTEASE-ACTIVATING
FACTOR 1
(Homo
sapiens)		4 / 7SER A 891
ASP A 893
SER A 895
SER A 896
None
0.96A13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2477_1
(NEURAMINIDASE)		2f28 SIALIDASE 2
(Homo
sapiens)		5 / 12ARG A  21
GLU A 218
ARG A 237
ARG A 304
TYR A 334
None
0.45A21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2477_1
(NEURAMINIDASE)		4mel UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 11
(Homo
sapiens)		5 / 12GLU A  71
GLU A  50
GLU A  43
ARG A  49
TYR A  67
None
1.36A18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2477_1
(NEURAMINIDASE)		6eih 14-3-3 PROTEIN
EPSILON
(Homo
sapiens)		5 / 12ARG A  61
GLU A 183
ARG A 130
ASN A 176
ARG A  57
None
0.94A14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2477_1
(NEURAMINIDASE)		6fel 14-3-3 PROTEIN GAMMA
(Homo
sapiens)		5 / 12ARG A  61
GLU A 185
ARG A 132
ASN A 178
ARG A  57
None
1.11A11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2477_2
(NEURAMINIDASE)		6c0w HISTONE H3-LIKE
CENTROMERIC PROTEIN
A
HISTONE H4
(Homo
sapiens)		4 / 5LEU A  61
ARG B  35
ARG B  36
ILE B  46
LEU  A  61 ( 0.6A)
ARG  B  35 ( 0.6A)
ARG  B  36 ( 0.6A)
ILE  B  46 ( 0.7A)
1.41A11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2478_1
(NEURAMINIDASE)		1aye PROCARBOXYPEPTIDASE
A2
(Homo
sapiens)		4 / 8SER A 162
ASP A 163
SER A 164
SER A 157
None
1.01A23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2478_1
(NEURAMINIDASE)		1dtd CARBOXYPEPTIDASE A2
(Homo
sapiens)		4 / 8ASP A 519
SER A 520
SER A 513
ASN A 515
None
1.12A22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2478_1
(NEURAMINIDASE)		1fs2 SKP2
(Homo
sapiens)		4 / 8SER A 276
SER A 250
ASN A 248
GLN A 196
None
1.13A21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2478_1
(NEURAMINIDASE)		1fs2 SKP2
(Homo
sapiens)		4 / 8SER A 303
ASP A 331
SER A 276
ASN A 301
None
1.06A21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2478_1
(NEURAMINIDASE)		2ass S-PHASE
KINASE-ASSOCIATED
PROTEIN 2
(Homo
sapiens)		4 / 8SER B2291
ASP B2319
SER B2264
ASN B2289
None
0.98A20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2478_1
(NEURAMINIDASE)		2coe DEOXYNUCLEOTIDYLTRAN
SFERASE, TERMINAL
VARIANT
(Homo
sapiens)		4 / 8SER A  71
ASP A  72
SER A  69
SER A 115
None
1.10A17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2478_1
(NEURAMINIDASE)		2z7x TOLL-LIKE RECEPTOR
1, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens)		4 / 8SER B 431
SER B 432
SER B 406
ASN B 429
NAG  A 831 (-3.6A)
NAG  A 833 ( 3.9A)
NAG  A 831 (-3.0A)
NAG  A 831 (-1.8A)
0.99A20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2478_1
(NEURAMINIDASE)		2z7x TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens)		4 / 8SER A 444
SER A 445
SER A 421
ASN A 442
NAG  A 921 ( 4.4A)
None
NAG  A 921 (-2.5A)
NAG  A 921 (-1.8A)
0.86A21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2478_1
(NEURAMINIDASE)		3qum FAB 5D5A5 HEAVY
CHAIN
PROSTATE-SPECIFIC
ANTIGEN
(Homo
sapiens;
Mus
musculus)		4 / 8SER B  30
SER B  53
SER P  86
GLN P  50
None
0.97A18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2478_1
(NEURAMINIDASE)		4bx9 VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 33A
(Homo
sapiens)		4 / 8ASP A 372
ASN A 390
GLN A 413
LYS A 405
None
1.10A21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2478_1
(NEURAMINIDASE)		4gos V-SET
DOMAIN-CONTAINING
T-CELL ACTIVATION
INHIBITOR 1
(Homo
sapiens)		4 / 8SER A  55
SER A 114
ASN A 112
GLN A 107
NAG  A 202 ( 4.5A)
NAG  A 201 (-3.2A)
NAG  A 201 (-1.9A)
NAG  A 201 (-4.7A)
1.10A15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2478_1
(NEURAMINIDASE)		4hcr PF-547659 HEAVY
CHAIN
(Homo
sapiens)		4 / 8SER H 104
ASP H 106
SER H 102
SER H 103
None
1.12A19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2478_1
(NEURAMINIDASE)		4kfz ANTI-LMO2 VH
(Homo
sapiens)		4 / 8SER C  56
SER C  57
SER C  52
ASN C  54
None
1.07A16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2478_1
(NEURAMINIDASE)		4nzu 13PL LIGHT CHAIN
(Homo
sapiens)		4 / 8SER H  55
SER H  56
SER H  52
ASN H  53
None
1.00A20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2478_1
(NEURAMINIDASE)		4rcj YTH
DOMAIN-CONTAINING
FAMILY PROTEIN 1
(Homo
sapiens)		4 / 8SER A 398
ASP A 400
SER A 396
TRP A 411
None
1.12A19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2478_1
(NEURAMINIDASE)		4z6g MICROTUBULE-ACTIN
CROSS-LINKING FACTOR
1, ISOFORMS 1/2/3/5
(Homo
sapiens)		4 / 8SER A 187
SER A 247
SER A 188
ASN A 185
None
1.14A21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2478_1
(NEURAMINIDASE)		5c2k TRANSFORMING PROTEIN
RHOA,RAC
GTPASE-ACTIVATING
PROTEIN 1
(Homo
sapiens)		4 / 8SER A  88
ASP A  90
SER A  91
SER A  85
None
1.12A19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2478_1
(NEURAMINIDASE)		5hdh TOLL-LIKE RECEPTOR 8
(Homo
sapiens)		4 / 8SER A  71
ASP A  72
SER A  50
ASN A  93
None
1.05A17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2478_1
(NEURAMINIDASE)		5te1 ATP-CITRATE SYNTHASE
(Homo
sapiens)		4 / 8SER A 574
SER A 577
GLN A 505
TRP A 502
None
1.03A19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2478_1
(NEURAMINIDASE)		5tet ATP-CITRATE SYNTHASE
(Homo
sapiens)		4 / 8SER B 574
SER B 577
GLN B 505
TRP B 502
None
1.03A22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2478_1
(NEURAMINIDASE)		5wve APOPTOTIC
PROTEASE-ACTIVATING
FACTOR 1
(Homo
sapiens)		4 / 8SER A 891
ASP A 893
SER A 895
SER A 896
None
1.04A13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3477_1
(NEURAMINIDASE)		2f28 SIALIDASE 2
(Homo
sapiens)		5 / 12ARG A  21
GLU A 218
ARG A 237
ARG A 304
TYR A 334
None
0.49A21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3477_1
(NEURAMINIDASE)		4b9d SERINE/THREONINE-PRO
TEIN KINASE NEK1
(Homo
sapiens)		5 / 12GLU A  25
GLU A  68
GLU A   2
ARG A  67
ARG A  28
None
1.29A20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3477_1
(NEURAMINIDASE)		4mel UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 11
(Homo
sapiens)		5 / 12GLU A  71
GLU A  50
GLU A  43
ARG A  49
TYR A  67
None
1.34A18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3477_1
(NEURAMINIDASE)		6eih 14-3-3 PROTEIN
EPSILON
(Homo
sapiens)		5 / 12ARG A  61
GLU A 183
ARG A 130
ASN A 176
ARG A  57
None
0.92A14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3477_1
(NEURAMINIDASE)		6fel 14-3-3 PROTEIN GAMMA
(Homo
sapiens)		5 / 12ARG A  61
GLU A 185
ARG A 132
ASN A 178
ARG A  57
None
1.12A11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3477_2
(NEURAMINIDASE)		6c0w HISTONE H3-LIKE
CENTROMERIC PROTEIN
A
HISTONE H4
(Homo
sapiens)		4 / 5LEU A  61
ARG B  35
ARG B  36
ILE B  46
LEU  A  61 ( 0.6A)
ARG  B  35 ( 0.6A)
ARG  B  36 ( 0.6A)
ILE  B  46 ( 0.7A)
1.41A11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3478_1
(NEURAMINIDASE)		1r47 ALPHA-GALACTOSIDASE
A
(Homo
sapiens)		4 / 8SER A 235
ASP A 233
SER A 238
GLN A 280
None
1.11A20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3478_1
(NEURAMINIDASE)		1xwd FOLLICLE STIMULATING
HORMONE RECEPTOR
(Homo
sapiens)		4 / 8SER C 226
SER C 201
ASN C 199
GLN C 152
None
1.04A19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3478_1
(NEURAMINIDASE)		2ass S-PHASE
KINASE-ASSOCIATED
PROTEIN 2
(Homo
sapiens)		4 / 8SER B2291
ASP B2319
SER B2264
ASN B2289
None
1.10A20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3478_1
(NEURAMINIDASE)		2ass S-PHASE
KINASE-ASSOCIATED
PROTEIN 2
(Homo
sapiens)		4 / 8SER B2318
ASP B2316
SER B2341
SER B2343
None
1.06A20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3478_1
(NEURAMINIDASE)		2z7x TOLL-LIKE RECEPTOR
1, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens)		4 / 8SER B 431
SER B 432
SER B 406
ASN B 429
NAG  A 831 (-3.6A)
NAG  A 833 ( 3.9A)
NAG  A 831 (-3.0A)
NAG  A 831 (-1.8A)
1.03A20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3478_1
(NEURAMINIDASE)		2z7x TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens)		4 / 8SER A 444
SER A 445
SER A 421
ASN A 442
NAG  A 921 ( 4.4A)
None
NAG  A 921 (-2.5A)
NAG  A 921 (-1.8A)
0.94A21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3478_1
(NEURAMINIDASE)		4f52 CULLIN-1
(Homo
sapiens)		4 / 8ASP A 427
SER A 479
ASN A 478
GLN A 477
None
1.13A17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3478_1
(NEURAMINIDASE)		4gnk 1-PHOSPHATIDYLINOSIT
OL 4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-3
(Homo
sapiens)		4 / 8SER B 202
SER B 200
ASN B 165
GLN B 166
None
1.09A14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3478_1
(NEURAMINIDASE)		4hcr PF-547659 HEAVY
CHAIN
(Homo
sapiens)		4 / 8SER H 104
ASP H 106
SER H 102
SER H 103
None
1.08A19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3478_1
(NEURAMINIDASE)		4kfz ANTI-LMO2 VH
(Homo
sapiens)		4 / 8SER C  56
SER C  57
SER C  52
ASN C  54
None
1.06A16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3478_1
(NEURAMINIDASE)		4nzu 13PL LIGHT CHAIN
(Homo
sapiens)		4 / 8SER H  55
SER H  56
SER H  52
ASN H  53
None
1.03A20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3478_1
(NEURAMINIDASE)		4rws C-X-C CHEMOKINE
RECEPTOR TYPE
4/ENDOLYSIN CHIMERIC
PROTEIN
(Escherichia
virus
T4;
Homo
sapiens)		4 / 8SER A 227
SER A 224
ASN A1068
GLN A1069
None
1.07A20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3478_1
(NEURAMINIDASE)		4v1d SINGLE CHAIN
ANTIBODY FRAGMENT
RU1, LIGHT CHAIN
(Homo
sapiens)		4 / 8SER E 170
ASP E 233
SER E 166
SER E 165
None
1.12A16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3478_1
(NEURAMINIDASE)		4wgk NEUTRAL CERAMIDASE
(Homo
sapiens)		4 / 8ASP A 352
SER A 258
SER A 261
GLN A 587
None
1.07A21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3478_1
(NEURAMINIDASE)		5a2e T-CELL
DIFFERENTIATION
ANTIGEN CD6
(Homo
sapiens)		4 / 8SER A  55
SER A  51
SER A  52
TRP A 238
None
1.02A20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3478_1
(NEURAMINIDASE)		5bzd 5G8 HIV ANTIBODY
HEAVY CHAIN
(Homo
sapiens)		4 / 8SER B  28
ASN B  76
GLN B  77
TRP B  34
None
0.97A20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3478_1
(NEURAMINIDASE)		5wve APOPTOTIC
PROTEASE-ACTIVATING
FACTOR 1
(Homo
sapiens)		4 / 8SER A 891
ASP A 893
SER A 895
SER A 896
None
0.92A13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4477_1
(NEURAMINIDASE)		2f28 SIALIDASE 2
(Homo
sapiens)		5 / 12ARG A  21
GLU A 218
ARG A 237
ARG A 304
TYR A 334
None
0.47A21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4477_1
(NEURAMINIDASE)		4mel UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 11
(Homo
sapiens)		5 / 12GLU A  71
GLU A  50
GLU A  43
ARG A  49
TYR A  67
None
1.38A18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4477_1
(NEURAMINIDASE)		6eih 14-3-3 PROTEIN
EPSILON
(Homo
sapiens)		5 / 12ARG A  61
GLU A 183
ARG A 130
ASN A 176
ARG A  57
None
0.98A14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4477_1
(NEURAMINIDASE)		6fel 14-3-3 PROTEIN GAMMA
(Homo
sapiens)		5 / 12ARG A  61
GLU A 185
ARG A 132
ASN A 178
ARG A  57
None
1.15A11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4478_1
(NEURAMINIDASE)		1aye PROCARBOXYPEPTIDASE
A2
(Homo
sapiens)		4 / 8SER A 162
ASP A 163
SER A 164
SER A 157
None
1.04A23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4478_1
(NEURAMINIDASE)		2ass S-PHASE
KINASE-ASSOCIATED
PROTEIN 2
(Homo
sapiens)		4 / 8SER B2291
ASP B2319
SER B2264
ASN B2289
None
1.10A20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4478_1
(NEURAMINIDASE)		2nmp CYSTATHIONINE
GAMMA-LYASE
(Homo
sapiens)		4 / 8SER A 226
SER A 206
ASN A 188
GLN A 196
None
1.15A20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4478_1
(NEURAMINIDASE)		2z7x TOLL-LIKE RECEPTOR
1, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens)		4 / 8SER B 431
SER B 432
SER B 406
ASN B 429
NAG  A 831 (-3.6A)
NAG  A 833 ( 3.9A)
NAG  A 831 (-3.0A)
NAG  A 831 (-1.8A)
1.12A20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4478_1
(NEURAMINIDASE)		2z7x TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens)		4 / 8SER A 444
SER A 445
SER A 421
ASN A 442
NAG  A 921 ( 4.4A)
None
NAG  A 921 (-2.5A)
NAG  A 921 (-1.8A)
1.02A21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4478_1
(NEURAMINIDASE)		4bx9 VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 33A
(Homo
sapiens)		4 / 8ASP A 372
ASN A 390
GLN A 413
LYS A 405
None
1.10A21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4478_1
(NEURAMINIDASE)		4gos V-SET
DOMAIN-CONTAINING
T-CELL ACTIVATION
INHIBITOR 1
(Homo
sapiens)		4 / 8SER A  55
SER A 114
ASN A 112
GLN A 107
NAG  A 202 ( 4.5A)
NAG  A 201 (-3.2A)
NAG  A 201 (-1.9A)
NAG  A 201 (-4.7A)
1.05A15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4478_1
(NEURAMINIDASE)		4hcr PF-547659 HEAVY
CHAIN
(Homo
sapiens)		4 / 8SER H 104
ASP H 106
SER H 102
SER H 103
None
1.16A19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4478_1
(NEURAMINIDASE)		4kfz ANTI-LMO2 VH
(Homo
sapiens)		4 / 8SER C  56
SER C  57
SER C  52
ASN C  54
None
1.14A16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4478_1
(NEURAMINIDASE)		4nzu 13PL LIGHT CHAIN
(Homo
sapiens)		4 / 8SER H  55
SER H  56
SER H  52
ASN H  53
None
1.10A20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4478_1
(NEURAMINIDASE)		4rcj YTH
DOMAIN-CONTAINING
FAMILY PROTEIN 1
(Homo
sapiens)		4 / 8SER A 398
ASP A 400
SER A 396
TRP A 411
None
1.14A19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4478_1
(NEURAMINIDASE)		4v1d SINGLE CHAIN
ANTIBODY FRAGMENT
RU1, LIGHT CHAIN
(Homo
sapiens)		4 / 8SER E 170
ASP E 233
SER E 166
SER E 165
None
1.12A16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4478_1
(NEURAMINIDASE)		5a2e T-CELL
DIFFERENTIATION
ANTIGEN CD6
(Homo
sapiens)		4 / 8SER A  55
SER A  51
SER A  52
TRP A 238
None
1.00A20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4478_1
(NEURAMINIDASE)		5hdh TOLL-LIKE RECEPTOR 8
(Homo
sapiens)		4 / 8SER A  71
ASP A  72
SER A  50
ASN A  93
None
1.16A17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4478_1
(NEURAMINIDASE)		5wve APOPTOTIC
PROTEASE-ACTIVATING
FACTOR 1
(Homo
sapiens)		4 / 8SER A 891
ASP A 893
SER A 895
SER A 896
None
0.94A13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4478_1
(NEURAMINIDASE)		5x49 PROBABLE XAA-PRO
AMINOPEPTIDASE 3
(Homo
sapiens)		4 / 8SER A 101
ASP A 131
SER A 132
GLN A 128
None
1.09A20.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2F0Z_A_ZMRA381_1
(SIALIDASE 2)		2f28 SIALIDASE 2
(Homo
sapiens)		10 / 12ARG A  21
GLU A  39
MET A  85
ASN A  86
TYR A 179
TYR A 181
GLU A 218
ARG A 237
ARG A 304
TYR A 334
None
0.59A99.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HTQ_A_ZMRA472_1
(NEURAMINIDASE)		2f28 SIALIDASE 2
(Homo
sapiens)		5 / 12ARG A  21
GLU A 218
ARG A 237
ARG A 304
TYR A 334
None
0.63A21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HTQ_A_ZMRA472_1
(NEURAMINIDASE)		4mel UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 11
(Homo
sapiens)		5 / 12GLU A  71
GLU A  50
GLU A  43
ARG A  49
TYR A  67
None
1.28A20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_1
(NEURAMINIDASE A)		2f28 SIALIDASE 2
(Homo
sapiens)		6 / 12ARG A  21
ILE A  22
TYR A 179
ARG A 237
ARG A 304
TYR A 334
None
0.41A23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_2
(NEURAMINIDASE A)		1k8f ADENYLYL
CYCLASE-ASSOCIATED
PROTEIN
(Homo
sapiens)		4 / 6ASP A 383
ILE A 363
LEU A 361
GLU A 343
None
0.92A20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_2
(NEURAMINIDASE A)		2abj BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE,
CYTOSOLIC
(Homo
sapiens)		4 / 6ASP A 340
ILE A 350
LEU A 318
GLU A 354
None
0.95A21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_2
(NEURAMINIDASE A)		2b5m DAMAGE-SPECIFIC DNA
BINDING PROTEIN 1
(Homo
sapiens)		4 / 6ASP A1099
ILE A1100
LEU A1058
TYR A  58
None
1.04A18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_2
(NEURAMINIDASE A)		2cqk C-MPL BINDING
PROTEIN
(Homo
sapiens)		4 / 6ASP A  99
ILE A 103
LEU A  53
GLU A 105
None
1.03A10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_2
(NEURAMINIDASE A)		2ija ARYLAMINE
N-ACETYLTRANSFERASE
1
(Homo
sapiens)		4 / 6ASP A 251
ILE A 253
LEU A 181
TYR A 129
None
1.07A21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_2
(NEURAMINIDASE A)		3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens)		4 / 6ASP A 540
ILE A 539
LEU A 565
GLU A 570
None
1.08A21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_2
(NEURAMINIDASE A)		3nmz APC VARIANT PROTEIN
(Homo
sapiens)		4 / 6ASP A 605
ILE A 606
LEU A 592
GLU A 574
None
1.05A22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_2
(NEURAMINIDASE A)		3x05 PHOSPHATIDYLINOSITOL
5-PHOSPHATE 4-KINASE
TYPE-2 BETA
(Homo
sapiens)		4 / 6ARG A 224
ILE A 414
LEU A 250
GLU A 246
None
1.02A22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_2
(NEURAMINIDASE A)		4b92 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens)		4 / 6ASP A  64
ILE A  63
LEU A 385
TYR A 244
None
1.08A21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_2
(NEURAMINIDASE A)		4c9b PRE-MRNA-SPLICING
FACTOR CWC22 HOMOLOG
(Homo
sapiens)		4 / 6ASP B 374
ILE B 238
LEU B 273
GLU B 231
None
1.07A19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_2
(NEURAMINIDASE A)		4cak INTEGRIN ALPHA-IIB
(Homo
sapiens)		4 / 6ASP A 605
ILE A 487
LEU A 508
GLU A 594
None
1.05A18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_2
(NEURAMINIDASE A)		4cak INTEGRIN ALPHA-IIB
(Homo
sapiens)		4 / 6ASP A 605
ILE A 487
LEU A 508
TYR A 645
None
0.98A18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_2
(NEURAMINIDASE A)		4oiv BILE ACID RECEPTOR
(Homo
sapiens)		4 / 6ASP A 404
ILE A 402
LEU A 323
GLU A 409
None
1.06A17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_2
(NEURAMINIDASE A)		5awn HEAVY CHAIN OF
3BC176 FAB
(Homo
sapiens)		4 / 6ASP H  52
ILE H  51
LEU H  78
TYR H  27
None
1.07A18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_2
(NEURAMINIDASE A)		5k8r PROTOCADHERIN
GAMMA-B3
(Homo
sapiens)		4 / 6ASP A  58
ILE A  60
LEU A  74
GLU A  64
None
1.02A22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_2
(NEURAMINIDASE A)		5vhi 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT 6
(Homo
sapiens)		4 / 6ARG Y 101
ASP Y 139
LEU Y 180
GLU Y 170
None
0.80A21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_1
(NEURAMINIDASE A)		2f28 SIALIDASE 2
(Homo
sapiens)		6 / 12ARG A  21
ILE A  22
TYR A 179
ARG A 237
ARG A 304
TYR A 334
None
0.42A23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_2
(NEURAMINIDASE A)		1k8f ADENYLYL
CYCLASE-ASSOCIATED
PROTEIN
(Homo
sapiens)		4 / 6ASP A 383
ILE A 363
LEU A 361
GLU A 343
None
0.87A20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_2
(NEURAMINIDASE A)		1w6v UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15
(Homo
sapiens)		4 / 6ASP A  15
ILE A  16
LEU A 100
GLU A  95
None
1.06A16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_2
(NEURAMINIDASE A)		2abj BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE,
CYTOSOLIC
(Homo
sapiens)		4 / 6ASP A 340
ILE A 350
LEU A 318
GLU A 354
None
0.93A21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_2
(NEURAMINIDASE A)		2b5m DAMAGE-SPECIFIC DNA
BINDING PROTEIN 1
(Homo
sapiens)		4 / 6ASP A1099
ILE A1100
LEU A1058
TYR A  58
None
1.04A18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_2
(NEURAMINIDASE A)		2ija ARYLAMINE
N-ACETYLTRANSFERASE
1
(Homo
sapiens)		4 / 6ASP A 251
ILE A 253
LEU A 181
TYR A 129
None
1.06A21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_2
(NEURAMINIDASE A)		3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens)		4 / 6ASP A 540
ILE A 539
LEU A 565
GLU A 570
None
1.04A21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_2
(NEURAMINIDASE A)		3nmz APC VARIANT PROTEIN
(Homo
sapiens)		4 / 6ASP A 605
ILE A 606
LEU A 592
GLU A 574
None
1.06A22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_2
(NEURAMINIDASE A)		3x05 PHOSPHATIDYLINOSITOL
5-PHOSPHATE 4-KINASE
TYPE-2 BETA
(Homo
sapiens)		4 / 6ARG A 224
ILE A 414
LEU A 250
GLU A 246
None
1.01A22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_2
(NEURAMINIDASE A)		4cak INTEGRIN ALPHA-IIB
(Homo
sapiens)		4 / 6ASP A 605
ILE A 487
LEU A 508
GLU A 594
None
1.01A18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_2
(NEURAMINIDASE A)		4cak INTEGRIN ALPHA-IIB
(Homo
sapiens)		4 / 6ASP A 605
ILE A 487
LEU A 508
TYR A 645
None
0.95A18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_2
(NEURAMINIDASE A)		4kq8 CYTOCHROME P450 19A1
(Homo
sapiens)		4 / 6ASP A 384
ILE A  97
LEU A 396
GLU A 405
None
1.08A21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_2
(NEURAMINIDASE A)		4oiv BILE ACID RECEPTOR
(Homo
sapiens)		4 / 6ASP A 404
ILE A 402
LEU A 323
GLU A 409
None
1.07A17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_2
(NEURAMINIDASE A)		5awn HEAVY CHAIN OF
3BC176 FAB
(Homo
sapiens)		4 / 6ASP H  52
ILE H  51
LEU H  78
TYR H  27
None
1.05A18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_2
(NEURAMINIDASE A)		5f9o CH235.9 HEAVY CHAIN
(Homo
sapiens)		4 / 6ASP H  52
ILE H  51
LEU H  79
TYR H  27
None
1.07A20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_2
(NEURAMINIDASE A)		5k8r PROTOCADHERIN
GAMMA-B3
(Homo
sapiens)		4 / 6ASP A  58
ILE A  60
LEU A  74
GLU A  64
None
1.00A22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_2
(NEURAMINIDASE A)		5vhi 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT 6
(Homo
sapiens)		4 / 6ARG Y 101
ASP Y 139
LEU Y 180
GLU Y 170
None
0.78A21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_C_ZMRC1776_1
(NEURAMINIDASE A)		2f28 SIALIDASE 2
(Homo
sapiens)		6 / 12ARG A  21
ILE A  22
TYR A 179
ARG A 237
ARG A 304
TYR A 334
None
0.41A23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_C_ZMRC1776_1
(NEURAMINIDASE A)		6ejb XYLOSYLTRANSFERASE 1
(Homo
sapiens)		5 / 12ARG A 957
ASP A 433
PHE A 330
LEU A 422
TYR A 617
None
1.48A11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_C_ZMRC1776_2
(NEURAMINIDASE A)		1b55 TYROSINE-PROTEIN
KINASE BTK
(Homo
sapiens)		4 / 6ASP A  57
ILE A  56
GLN A  15
GLU A 108
None
None
4IP  A 171 (-4.6A)
None
1.29A15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_C_ZMRC1776_2
(NEURAMINIDASE A)		1mwp AMYLOID A4 PROTEIN
(Homo
sapiens)		4 / 6ASP A  64
ILE A  63
GLN A  71
GLU A  67
None
0.88A12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_C_ZMRC1776_2
(NEURAMINIDASE A)		1p49 STERYL-SULFATASE
(Homo
sapiens)		4 / 6ARG A 522
ASP A 504
ILE A 505
GLN A  67
None
1.09A20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_C_ZMRC1776_2
(NEURAMINIDASE A)		1u31 NAD(P)
TRANSHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens)		4 / 6ARG A 202
ASP A  67
ILE A  65
GLN A  62
None
1.33A17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_C_ZMRC1776_2
(NEURAMINIDASE A)		2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens)		4 / 6ARG A 424
ILE A 415
GLN A 418
GLU A 290
None
1.44A22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_C_ZMRC1776_2
(NEURAMINIDASE A)		4a0k CULLIN-4A
(Homo
sapiens)		4 / 6ARG A 742
ASP A 697
ILE A 696
GLN A 722
None
1.26A21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_C_ZMRC1776_2
(NEURAMINIDASE A)		4el1 PROTEIN
DISULFIDE-ISOMERASE
(Homo
sapiens)		4 / 6ARG A 132
ASP A 180
ILE A 179
GLN A 233
None
1.32A24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_C_ZMRC1776_2
(NEURAMINIDASE A)		4jfn AMYLOID BETA A4
PROTEIN
(Homo
sapiens)		4 / 6ASP A  64
ILE A  63
GLN A  71
GLU A  67
None
0.79A15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_C_ZMRC1776_2
(NEURAMINIDASE A)		4jvs PUTATIVE
UNCHARACTERIZED
PROTEIN
RAS-RELATED PROTEIN
RAB-1A
(Homo
sapiens;
Legionella
drancourtii)		4 / 6ASP A 495
ILE A 487
GLN A 483
TYR B  80
None
1.37A20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_C_ZMRC1776_2
(NEURAMINIDASE A)		4kc3 INTERLEUKIN-1
RECEPTOR-LIKE 1
INTERLEUKIN-33
(Homo
sapiens)		4 / 6ASP A 157
ILE A 134
GLU A 148
TYR B 119
None
1.26A16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_C_ZMRC1776_2
(NEURAMINIDASE A)		5anb ELONGATION FACTOR TU
GTP-BINDING
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens)		4 / 6ARG K 373
ASP K 111
ILE K  19
GLN K  13
None
1.38A18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_C_ZMRC1776_2
(NEURAMINIDASE A)		5chl HISTONE H2A.Z
VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 72 HOMOLOG
(Drosophila
melanogaster;
Homo
sapiens)		4 / 6ASP A  59
ILE A  62
GLU A  64
TYR B  90
None
1.19A9.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_C_ZMRC1776_2
(NEURAMINIDASE A)		5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens)		4 / 6ARG A 932
ASP A1042
ILE A1043
GLU A1034
None
None
None
EDO  A1603 (-2.7A)
1.41A15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_C_ZMRC1776_2
(NEURAMINIDASE A)		5e84 78 KDA
GLUCOSE-REGULATED
PROTEIN
(Homo
sapiens)		4 / 6ASP A 186
ILE A 190
GLU A 533
TYR A 127
None
1.34A22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_C_ZMRC1776_2
(NEURAMINIDASE A)		5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens)		4 / 6ARG B3971
ASP B4289
GLN B4298
GLU B4246
None
1.46A21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_C_ZMRC1776_2
(NEURAMINIDASE A)		5ukw GLUCOSE-6-PHOSPHATE
1-DEHYDROGENASE
(Homo
sapiens)		4 / 6ARG A 246
GLN A 395
GLU A 239
TYR A 202
None
BG6  A 601 (-3.2A)
BG6  A 601 (-2.9A)
BG6  A 601 (-4.8A)
1.42A21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_1
(NEURAMINIDASE A)		2f28 SIALIDASE 2
(Homo
sapiens)		6 / 12ARG A  21
ILE A  22
TYR A 179
ARG A 237
ARG A 304
TYR A 334
None
0.41A23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_2
(NEURAMINIDASE A)		1k8f ADENYLYL
CYCLASE-ASSOCIATED
PROTEIN
(Homo
sapiens)		4 / 6ASP A 383
ILE A 363
LEU A 361
GLU A 343
None
0.90A20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_2
(NEURAMINIDASE A)		1w6v UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15
(Homo
sapiens)		4 / 6ASP A  15
ILE A  16
LEU A 100
GLU A  95
None
1.07A16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_2
(NEURAMINIDASE A)		2abj BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE,
CYTOSOLIC
(Homo
sapiens)		4 / 6ASP A 340
ILE A 350
LEU A 318
GLU A 354
None
0.96A21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_2
(NEURAMINIDASE A)		2b5m DAMAGE-SPECIFIC DNA
BINDING PROTEIN 1
(Homo
sapiens)		4 / 6ASP A1099
ILE A1100
LEU A1058
TYR A  58
None
1.04A18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_2
(NEURAMINIDASE A)		2ija ARYLAMINE
N-ACETYLTRANSFERASE
1
(Homo
sapiens)		4 / 6ASP A 251
ILE A 253
LEU A 181
TYR A 129
None
1.06A21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_2
(NEURAMINIDASE A)		3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens)		4 / 6ASP A 540
ILE A 539
LEU A 565
GLU A 570
None
1.06A21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_2
(NEURAMINIDASE A)		3ikm DNA POLYMERASE
SUBUNIT GAMMA-1
(Homo
sapiens)		4 / 6ARG A1234
ILE A1155
LEU A1159
GLU A  85
None
1.07A16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_2
(NEURAMINIDASE A)		3nmz APC VARIANT PROTEIN
(Homo
sapiens)		4 / 6ASP A 605
ILE A 606
LEU A 592
GLU A 574
None
1.06A22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_2
(NEURAMINIDASE A)		3x05 PHOSPHATIDYLINOSITOL
5-PHOSPHATE 4-KINASE
TYPE-2 BETA
(Homo
sapiens)		4 / 6ARG A 224
ILE A 414
LEU A 250
GLU A 246
None
1.02A22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_2
(NEURAMINIDASE A)		4cak INTEGRIN ALPHA-IIB
(Homo
sapiens)		4 / 6ASP A 605
ILE A 487
LEU A 508
GLU A 594
None
1.04A18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_2
(NEURAMINIDASE A)		4cak INTEGRIN ALPHA-IIB
(Homo
sapiens)		4 / 6ASP A 605
ILE A 487
LEU A 508
TYR A 645
None
0.96A18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_2
(NEURAMINIDASE A)		5awn HEAVY CHAIN OF
3BC176 FAB
(Homo
sapiens)		4 / 6ASP H  52
ILE H  51
LEU H  78
TYR H  27
None
1.05A18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_2
(NEURAMINIDASE A)		5f9o CH235.9 HEAVY CHAIN
(Homo
sapiens)		4 / 6ASP H  52
ILE H  51
LEU H  79
TYR H  27
None
1.07A20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_2
(NEURAMINIDASE A)		5k8r PROTOCADHERIN
GAMMA-B3
(Homo
sapiens)		4 / 6ASP A  58
ILE A  60
LEU A  74
GLU A  64
None
1.04A22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_2
(NEURAMINIDASE A)		5vhi 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT 6
(Homo
sapiens)		4 / 6ARG Y 101
ASP Y 139
LEU Y 180
GLU Y 170
None
0.79A21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B7E_A_ZMRA1001_1
(NEURAMINIDASE)		2f28 SIALIDASE 2
(Homo
sapiens)		5 / 12ARG A  21
GLU A 218
ARG A 237
ARG A 304
TYR A 334
None
0.42A20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B7E_A_ZMRA1001_1
(NEURAMINIDASE)		4mel UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 11
(Homo
sapiens)		5 / 12GLU A  71
GLU A  50
GLU A  43
ARG A  49
TYR A  67
None
1.32A20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B7E_B_ZMRB1002_1
(NEURAMINIDASE)		2f28 SIALIDASE 2
(Homo
sapiens)		5 / 12ARG A  21
GLU A 218
ARG A 237
ARG A 304
TYR A 334
None
0.42A20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B7E_B_ZMRB1002_1
(NEURAMINIDASE)		4mel UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 11
(Homo
sapiens)		5 / 12GLU A  71
GLU A  50
GLU A  43
ARG A  49
TYR A  67
None
1.32A20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKZ_A_ZMRA469_1
(NEURAMINIDASE)		2f28 SIALIDASE 2
(Homo
sapiens)		5 / 12ARG A  21
GLU A 218
ARG A 237
ARG A 304
TYR A 334
None
0.43A22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKZ_A_ZMRA469_1
(NEURAMINIDASE)		5exr DNA POLYMERASE ALPHA
SUBUNIT B
(Homo
sapiens)		5 / 12ARG D 545
GLU D 169
ARG D 597
ASN D 166
TYR D 546
None
1.27A21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKZ_A_ZMRA469_1
(NEURAMINIDASE)		5fql IDURONATE-2-SULFATAS
E
(Homo
sapiens)		5 / 12GLU A 341
TYR A 264
GLU A 344
ASN A 265
TYR A 348
None
1.37A21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKZ_A_ZMRA469_1
(NEURAMINIDASE)		6fel 14-3-3 PROTEIN GAMMA
(Homo
sapiens)		5 / 12ARG A  61
GLU A 185
ARG A 132
ASN A 178
ARG A  57
None
1.17A11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKZ_A_ZMRA469_2
(NEURAMINIDASE)		1qgr PROTEIN (IMPORTIN
BETA SUBUNIT)
(Homo
sapiens)		4 / 6ASP A 579
ARG A 525
ARG A 574
SER A 621
None
1.31A16.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKZ_A_ZMRA469_2
(NEURAMINIDASE)		2nn6 POLYMYOSITIS/SCLEROD
ERMA AUTOANTIGEN 1
(Homo
sapiens)		4 / 6ASP A 208
ARG A  27
ILE A 261
SER A 150
None
1.31A17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKZ_A_ZMRA469_2
(NEURAMINIDASE)		3c6m SPERMINE SYNTHASE
(Homo
sapiens)		4 / 6ASP A 135
ARG A 122
ILE A 161
SER A 173
None
1.12A22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKZ_A_ZMRA469_2
(NEURAMINIDASE)		3fay RAS
GTPASE-ACTIVATING-LI
KE PROTEIN IQGAP1
(Homo
sapiens)		4 / 6ASP A1132
ARG A1136
ILE A1094
ARG A1130
None
1.41A20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKZ_A_ZMRA469_2
(NEURAMINIDASE)		4pwn SERINE/THREONINE-PRO
TEIN KINASE WNK1
(Homo
sapiens)		4 / 6ASP A 400
ARG A 467
ILE A 346
ARG A 348
None
1.24A20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKZ_A_ZMRA469_2
(NEURAMINIDASE)		5epg ALDEHYDE OXIDASE
(Homo
sapiens)		4 / 6ASP A 289
ARG A 234
ILE A 291
SER A 295
None
1.10A14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKZ_A_ZMRA469_2
(NEURAMINIDASE)		5mvd DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL
(Homo
sapiens)		4 / 6ASP A 140
ILE A 144
ARG A 289
SER A 299
None
1.48A23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKZ_A_ZMRA469_2
(NEURAMINIDASE)		5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens)		4 / 6ASP A1455
TRP A1456
ILE A1457
SER A1478
None
1.32A21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SAN_A_ZMRA901_1
(NEURAMINIDASE)		1y4j SULFATASE MODIFYING
FACTOR 2
(Homo
sapiens)		5 / 12ARG A  55
GLU A 167
ALA A 173
GLU A 166
ARG A 253
None
1.43A19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SAN_A_ZMRA901_1
(NEURAMINIDASE)		2f28 SIALIDASE 2
(Homo
sapiens)		5 / 12ARG A  21
GLU A 218
ARG A 237
ARG A 304
TYR A 334
None
0.39A20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SAN_A_ZMRA901_1
(NEURAMINIDASE)		4mel UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 11
(Homo
sapiens)		5 / 12GLU A  71
GLU A  50
GLU A  43
ARG A  49
TYR A  67
None
1.33A19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SAN_A_ZMRA901_1
(NEURAMINIDASE)		6fel 14-3-3 PROTEIN GAMMA
(Homo
sapiens)		5 / 12ARG A  61
GLU A 185
ARG A 132
ASN A 178
ARG A  57
None
1.18A13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SAN_B_ZMRB901_1
(NEURAMINIDASE)		1y4j SULFATASE MODIFYING
FACTOR 2
(Homo
sapiens)		5 / 12ARG A  55
GLU A 167
ALA A 173
GLU A 166
ARG A 253
None
1.43A19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SAN_B_ZMRB901_1
(NEURAMINIDASE)		2f28 SIALIDASE 2
(Homo
sapiens)		5 / 12ARG A  21
GLU A 218
ARG A 237
ARG A 304
TYR A 334
None
0.39A20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SAN_B_ZMRB901_1
(NEURAMINIDASE)		4mel UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 11
(Homo
sapiens)		5 / 12GLU A  71
GLU A  50
GLU A  43
ARG A  49
TYR A  67
None
1.32A19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SAN_B_ZMRB901_1
(NEURAMINIDASE)		6fel 14-3-3 PROTEIN GAMMA
(Homo
sapiens)		5 / 12ARG A  61
GLU A 185
ARG A 132
ASN A 178
ARG A  57
None
1.17A13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TI5_A_ZMRA1002_1
(NEURAMINIDASE)		2f28 SIALIDASE 2
(Homo
sapiens)		5 / 12ARG A  21
GLU A 218
ARG A 237
ARG A 304
TYR A 334
None
0.40A21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TI5_A_ZMRA1002_1
(NEURAMINIDASE)		4mel UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 11
(Homo
sapiens)		5 / 12GLU A  71
GLU A  50
GLU A  43
ARG A  49
TYR A  67
None
1.31A18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TI5_A_ZMRA1002_1
(NEURAMINIDASE)		6fel 14-3-3 PROTEIN GAMMA
(Homo
sapiens)		5 / 12ARG A  61
GLU A 185
ARG A 132
ASN A 178
ARG A  57
None
1.18A11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TI5_B_ZMRB1002_1
(NEURAMINIDASE)		2f28 SIALIDASE 2
(Homo
sapiens)		5 / 12ARG A  21
GLU A 218
ARG A 237
ARG A 304
TYR A 334
None
0.41A21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TI5_B_ZMRB1002_1
(NEURAMINIDASE)		4mel UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 11
(Homo
sapiens)		5 / 12GLU A  71
GLU A  50
GLU A  43
ARG A  49
TYR A  67
None
1.31A18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TI5_B_ZMRB1002_1
(NEURAMINIDASE)		6fel 14-3-3 PROTEIN GAMMA
(Homo
sapiens)		5 / 12ARG A  61
GLU A 185
ARG A 132
ASN A 178
ARG A  57
None
1.17A11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_A_ZMRA1002_1
(NEURAMINIDASE)		1rzg FAB 412D LIGHT CHAIN
(Homo
sapiens)		5 / 12ARG A  83
GLU A  85
ASP A  86
GLU A  46
ARG A  62
None
None
None
SUC  A9002 (-2.9A)
SUC  A9002 (-4.2A)
1.46A18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_A_ZMRA1002_1
(NEURAMINIDASE)		2f28 SIALIDASE 2
(Homo
sapiens)		5 / 12ARG A  21
GLU A 218
ARG A 237
ARG A 304
TYR A 334
None
0.42A19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_A_ZMRA1002_1
(NEURAMINIDASE)		4mel UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 11
(Homo
sapiens)		5 / 12GLU A  71
GLU A  50
GLU A  43
ARG A  49
TYR A  67
None
1.32A16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_A_ZMRA1002_1
(NEURAMINIDASE)		6fel 14-3-3 PROTEIN GAMMA
(Homo
sapiens)		5 / 12ARG A  61
GLU A 185
ARG A 132
ASN A 178
ARG A  57
None
1.12A10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_A_ZMRA1002_2
(NEURAMINIDASE)		1d7w MYELOPEROXIDASE
(Homo
sapiens)		4 / 5LEU C 310
ARG C 507
ILE C 290
ARG C 294
None
0.99A21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_A_ZMRA1002_2
(NEURAMINIDASE)		1h2t 80 KDA NUCLEAR CAP
BINDING PROTEIN
(Homo
sapiens)		4 / 5LEU C 229
ARG C 166
ARG C 206
ARG C 165
None
1.04A20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_A_ZMRA1002_2
(NEURAMINIDASE)		2c47 CASEIN KINASE 1
GAMMA 2 ISOFORM
(Homo
sapiens)		4 / 5LEU A 297
ARG A 295
ILE A 276
ARG A 292
None
1.41A20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_A_ZMRA1002_2
(NEURAMINIDASE)		2ibu ACETYL-COA
ACETYLTRANSFERASE
(Homo
sapiens)		4 / 5LEU A 383
ARG A 393
ILE A 376
ARG A 221
None
1.27A21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_A_ZMRA1002_2
(NEURAMINIDASE)		4px9 ATP-DEPENDENT RNA
HELICASE DDX3X
(Homo
sapiens)		4 / 5LEU A 320
ARG A 326
ILE A 306
ARG A 333
None
1.34A21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_A_ZMRA1002_2
(NEURAMINIDASE)		5e7j ATP-DEPENDENT RNA
HELICASE DDX3X
(Homo
sapiens)		4 / 5LEU A 320
ARG A 326
ILE A 306
ARG A 333
None
1.36A20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_A_ZMRA1002_2
(NEURAMINIDASE)		5ggg PROTEIN
O-LINKED-MANNOSE
BETA-1,2-N-ACETYLGLU
COSAMINYLTRANSFERASE
1
(Homo
sapiens)		4 / 5LEU A 457
ARG A 485
ARG A 488
ARG A 480
None
1.32A21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_A_ZMRA1002_2
(NEURAMINIDASE)		5hkj COMPLEMENT C1Q
SUBCOMPONENT SUBUNIT
A,COMPLEMENT C1Q
SUBCOMPONENT SUBUNIT
C,COMPLEMENT C1Q
SUBCOMPONENT SUBUNIT
B
(Homo
sapiens)		4 / 5LEU A 381
ARG A 285
ILE A 287
ARG A 298
None
1.37A22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_A_ZMRA1002_2
(NEURAMINIDASE)		5j39 TUDOR AND KH
DOMAIN-CONTAINING
PROTEIN
(Homo
sapiens)		4 / 5LEU A 412
ARG A 329
ILE A 417
ARG A 301
None
1.35A17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_A_ZMRA1002_2
(NEURAMINIDASE)		5mfa MYELOPEROXIDASE
(Homo
sapiens)		4 / 5LEU A 476
ARG A 673
ILE A 456
ARG A 460
None
1.04A20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_A_ZMRA1002_2
(NEURAMINIDASE)		6azp MYELOPEROXIDASE
(Homo
sapiens)		4 / 5LEU A 476
ARG A 673
ILE A 456
ARG A 460
None
1.00A12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_A_ZMRA1002_2
(NEURAMINIDASE)		6c0w HISTONE H3-LIKE
CENTROMERIC PROTEIN
A
HISTONE H4
(Homo
sapiens)		4 / 5LEU A  61
ARG B  35
ARG B  36
ILE B  46
LEU  A  61 ( 0.6A)
ARG  B  35 ( 0.6A)
ARG  B  36 ( 0.6A)
ILE  B  46 ( 0.7A)
1.43A9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_B_ZMRB1002_1
(NEURAMINIDASE)		1rzg FAB 412D LIGHT CHAIN
(Homo
sapiens)		5 / 12ARG A  83
GLU A  85
ASP A  86
GLU A  46
ARG A  62
None
None
None
SUC  A9002 (-2.9A)
SUC  A9002 (-4.2A)
1.46A18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_B_ZMRB1002_1
(NEURAMINIDASE)		1y4j SULFATASE MODIFYING
FACTOR 2
(Homo
sapiens)		5 / 12ARG A  55
GLU A 167
ALA A 173
GLU A 166
ARG A 253
None
1.44A19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_B_ZMRB1002_1
(NEURAMINIDASE)		2f28 SIALIDASE 2
(Homo
sapiens)		5 / 12ARG A  21
GLU A 218
ARG A 237
ARG A 304
TYR A 334
None
0.44A19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_B_ZMRB1002_1
(NEURAMINIDASE)		4mel UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 11
(Homo
sapiens)		5 / 12GLU A  71
GLU A  50
GLU A  43
ARG A  49
TYR A  67
None
1.32A16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_B_ZMRB1002_1
(NEURAMINIDASE)		6fel 14-3-3 PROTEIN GAMMA
(Homo
sapiens)		5 / 12ARG A  61
GLU A 185
ARG A 132
ASN A 178
ARG A  57
None
1.13A10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_C_ZMRC1002_1
(NEURAMINIDASE)		1rzg FAB 412D LIGHT CHAIN
(Homo
sapiens)		5 / 12ARG A  83
GLU A  85
ASP A  86
GLU A  46
ARG A  62
None
None
None
SUC  A9002 (-2.9A)
SUC  A9002 (-4.2A)
1.46A18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_C_ZMRC1002_1
(NEURAMINIDASE)		2f28 SIALIDASE 2
(Homo
sapiens)		5 / 12ARG A  21
GLU A 218
ARG A 237
ARG A 304
TYR A 334
None
0.43A19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_C_ZMRC1002_1
(NEURAMINIDASE)		4mel UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 11
(Homo
sapiens)		5 / 12GLU A  71
GLU A  50
GLU A  43
ARG A  49
TYR A  67
None
1.33A16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_C_ZMRC1002_1
(NEURAMINIDASE)		6fel 14-3-3 PROTEIN GAMMA
(Homo
sapiens)		5 / 12ARG A  61
GLU A 185
ARG A 132
ASN A 178
ARG A  57
None
1.13A10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_D_ZMRD1002_1
(NEURAMINIDASE)		1rzg FAB 412D LIGHT CHAIN
(Homo
sapiens)		5 / 12ARG A  83
GLU A  85
ASP A  86
GLU A  46
ARG A  62
None
None
None
SUC  A9002 (-2.9A)
SUC  A9002 (-4.2A)
1.47A18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_D_ZMRD1002_1
(NEURAMINIDASE)		2f28 SIALIDASE 2
(Homo
sapiens)		5 / 12ARG A  21
GLU A 218
ARG A 237
ARG A 304
TYR A 334
None
0.42A19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_D_ZMRD1002_1
(NEURAMINIDASE)		4mel UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 11
(Homo
sapiens)		5 / 12GLU A  71
GLU A  50
GLU A  43
ARG A  49
TYR A  67
None
1.33A16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_D_ZMRD1002_1
(NEURAMINIDASE)		6fel 14-3-3 PROTEIN GAMMA
(Homo
sapiens)		5 / 12ARG A  61
GLU A 185
ARG A 132
ASN A 178
ARG A  57
None
1.13A10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_D_ZMRD1002_2
(NEURAMINIDASE)		3p56 RIBONUCLEASE H2
SUBUNIT A
(Homo
sapiens)		4 / 5LEU A 220
ARG A 235
TRP A 238
ILE A 101
None
1.45A20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_D_ZMRD1002_2
(NEURAMINIDASE)		6c0w HISTONE H3-LIKE
CENTROMERIC PROTEIN
A
HISTONE H4
(Homo
sapiens)		4 / 5LEU A  61
ARG B  35
ARG B  36
ILE B  46
LEU  A  61 ( 0.6A)
ARG  B  35 ( 0.6A)
ARG  B  36 ( 0.6A)
ILE  B  46 ( 0.7A)
1.43A9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7N_A_ZMRA601_1
(NEURAMINIDASE)		2f28 SIALIDASE 2
(Homo
sapiens)		5 / 12ARG A  21
GLU A 218
ARG A 237
ARG A 304
TYR A 334
None
0.44A22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7N_A_ZMRA601_1
(NEURAMINIDASE)		2f28 SIALIDASE 2
(Homo
sapiens)		5 / 12ARG A 304
GLU A 355
GLU A  39
ARG A 237
TYR A 334
None
1.49A22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7N_A_ZMRA601_1
(NEURAMINIDASE)		4mel UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 11
(Homo
sapiens)		5 / 12GLU A  71
GLU A  50
GLU A  43
ARG A  49
TYR A  67
None
1.30A16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7N_A_ZMRA601_1
(NEURAMINIDASE)		6eih 14-3-3 PROTEIN
EPSILON
(Homo
sapiens)		5 / 12ARG A  61
GLU A 183
ARG A 130
ASN A 176
ARG A  57
None
0.98A8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7N_A_ZMRA601_1
(NEURAMINIDASE)		6fel 14-3-3 PROTEIN GAMMA
(Homo
sapiens)		5 / 12ARG A  61
GLU A 185
ARG A 132
ASN A 178
ARG A  57
None
1.14A9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7N_A_ZMRA601_2
(NEURAMINIDASE)		1ity TRF1
(Homo
sapiens)		3 / 3ARG A 423
ARG A 380
TRP A 383
None
1.39A8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7N_A_ZMRA601_2
(NEURAMINIDASE)		3jwe MGLL PROTEIN
(Homo
sapiens)		3 / 3ARG A  43
ARG A  73
TRP A  45
None
1.07A19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7N_A_ZMRA601_2
(NEURAMINIDASE)		3pta DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens)		3 / 3ARG A1574
ARG A 650
TRP A1170
None
None
SAH  A1601 (-4.9A)
1.25A19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7N_A_ZMRA601_2
(NEURAMINIDASE)		4kwg ALDEHYDE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens)		3 / 3ARG A  84
ARG A  77
TRP A  76
None
GAI  A 605 ( 4.6A)
None
1.22A20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7N_A_ZMRA601_2
(NEURAMINIDASE)		5fhz ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3
(Homo
sapiens)		3 / 3ARG A  96
ARG A  89
TRP A  88
None
1.14A21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7N_A_ZMRA601_2
(NEURAMINIDASE)		5wbs FRIZZLED-7,INHIBITOR
PEPTIDE FZ7-21
(Homo
sapiens)		3 / 3ARG A  98
ARG A 117
TRP A 112
None
1.39A9.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7N_A_ZMRA601_2
(NEURAMINIDASE)		5xtc NADH DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT
5, MITOCHONDRIAL
(Homo
sapiens)		3 / 3ARG a 123
ARG a 119
TRP a 110
None
1.35A12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7N_A_ZMRA601_2
(NEURAMINIDASE)		6b5i RETINAL
DEHYDROGENASE 2
(Homo
sapiens)		3 / 3ARG A 102
ARG A  95
TRP A  94
None
1.26A8.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_A_ZMRA601_1
(NEURAMINIDASE)		2f28 SIALIDASE 2
(Homo
sapiens)		5 / 12ARG A  21
GLU A 218
ARG A 237
ARG A 304
TYR A 334
None
0.43A22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_A_ZMRA601_1
(NEURAMINIDASE)		4mel UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 11
(Homo
sapiens)		5 / 12GLU A  71
GLU A  50
GLU A  43
ARG A  49
TYR A  67
None
1.23A16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_A_ZMRA601_2
(NEURAMINIDASE)		1oww FIBRONECTIN FIRST
TYPE III MODULE
(Homo
sapiens)		3 / 3ARG A  36
ARG A  38
ILE A  74
None
0.84A11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_A_ZMRA601_2
(NEURAMINIDASE)		4g1t INTERFERON-INDUCED
PROTEIN WITH
TETRATRICOPEPTIDE
REPEATS 2
(Homo
sapiens)		3 / 3ARG A 292
ARG A 258
ILE A 339
None
0.94A20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_A_ZMRA601_2
(NEURAMINIDASE)		5vcs ALPHA-1,6-MANNOSYL-G
LYCOPROTEIN
2-BETA-N-ACETYLGLUCO
SAMINYLTRANSFERASE
(Homo
sapiens)		3 / 3ARG A 444
ARG A 445
ILE A 332
None
0.86A11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_A_ZMRA601_2
(NEURAMINIDASE)		5xtw MACROPHAGE MANNOSE
RECEPTOR 1
(Homo
sapiens)		3 / 3ARG A 151
ARG A  23
ILE A 141
None
0.88A11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_A_ZMRA601_2
(NEURAMINIDASE)		6c01 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 3
(Homo
sapiens)		3 / 3ARG A 407
ARG A 405
ILE A 411
NAG  A 904 (-3.7A)
None
NAG  A 904 (-4.6A)
0.72A13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_B_ZMRB601_1
(NEURAMINIDASE)		1rzg FAB 412D LIGHT CHAIN
(Homo
sapiens)		5 / 12ARG A  83
GLU A  85
ASP A  86
GLU A  46
ARG A  62
None
None
None
SUC  A9002 (-2.9A)
SUC  A9002 (-4.2A)
1.47A18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_B_ZMRB601_1
(NEURAMINIDASE)		2f28 SIALIDASE 2
(Homo
sapiens)		5 / 12ARG A  21
GLU A 218
ARG A 237
ARG A 304
TYR A 334
None
0.47A22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_B_ZMRB601_1
(NEURAMINIDASE)		4mel UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 11
(Homo
sapiens)		5 / 12GLU A  71
GLU A  50
GLU A  43
ARG A  49
TYR A  67
None
1.23A16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_C_ZMRC601_1
(NEURAMINIDASE)		2f28 SIALIDASE 2
(Homo
sapiens)		5 / 12ARG A  21
GLU A 218
ARG A 237
ARG A 304
TYR A 334
None
0.42A22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_C_ZMRC601_1
(NEURAMINIDASE)		3wwt PROTEIN C'
SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION
1-ALPHA/BETA
(Homo
sapiens;
Murine
respirovirus)		5 / 12ARG B 154
GLU B 187
ASP A  65
GLU B 184
TYR B 180
None
1.38A13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_C_ZMRC601_1
(NEURAMINIDASE)		4mel UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 11
(Homo
sapiens)		5 / 12GLU A  71
GLU A  50
GLU A  43
ARG A  49
TYR A  67
None
1.32A16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_C_ZMRC601_2
(NEURAMINIDASE)		1oww FIBRONECTIN FIRST
TYPE III MODULE
(Homo
sapiens)		3 / 3ARG A  36
ARG A  38
ILE A  74
None
0.79A11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_C_ZMRC601_2
(NEURAMINIDASE)		2bfe 2-OXOISOVALERATE
DEHYDROGENASE ALPHA
SUBUNIT
(Homo
sapiens)		3 / 3ARG A  35
ARG A  39
ILE A  44
None
0.91A22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_C_ZMRC601_2
(NEURAMINIDASE)		3o57 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens)		3 / 3ARG A 335
ARG A 331
ILE A 339
None
0.92A20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_C_ZMRC601_2
(NEURAMINIDASE)		5vcs ALPHA-1,6-MANNOSYL-G
LYCOPROTEIN
2-BETA-N-ACETYLGLUCO
SAMINYLTRANSFERASE
(Homo
sapiens)		3 / 3ARG A 444
ARG A 445
ILE A 332
None
0.75A11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_C_ZMRC601_2
(NEURAMINIDASE)		5xts MACROPHAGE MANNOSE
RECEPTOR 1
(Homo
sapiens)		3 / 3ARG A 151
ARG A  23
ILE A 141
None
0.92A11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_C_ZMRC601_2
(NEURAMINIDASE)		5xtw MACROPHAGE MANNOSE
RECEPTOR 1
(Homo
sapiens)		3 / 3ARG A 151
ARG A  23
ILE A 141
None
0.75A11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_C_ZMRC601_2
(NEURAMINIDASE)		6c01 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 3
(Homo
sapiens)		3 / 3ARG A 407
ARG A 405
ILE A 411
NAG  A 904 (-3.7A)
None
NAG  A 904 (-4.6A)
0.59A13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_D_ZMRD601_1
(NEURAMINIDASE)		2f28 SIALIDASE 2
(Homo
sapiens)		5 / 12ARG A  21
GLU A 218
ARG A 237
ARG A 304
TYR A 334
None
0.48A22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_D_ZMRD601_1
(NEURAMINIDASE)		4mel UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 11
(Homo
sapiens)		5 / 12GLU A  71
GLU A  50
GLU A  43
ARG A  49
TYR A  67
None
1.32A16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_D_ZMRD601_1
(NEURAMINIDASE)		5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens)		5 / 12ARG A 929
ASP A 914
ARG A 814
GLU A1034
ARG A1039
None
None
EDO  A1603 (-3.9A)
EDO  A1603 (-2.7A)
EDO  A1603 ( 3.8A)
1.34A15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPN_A_ZMRA700_1
(NEURAMINIDASE)		2f28 SIALIDASE 2
(Homo
sapiens)		5 / 12ARG A  21
GLU A 218
ARG A 237
ARG A 304
TYR A 334
None
0.42A23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPN_A_ZMRA700_1
(NEURAMINIDASE)		3wwt PROTEIN C'
SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION
1-ALPHA/BETA
(Homo
sapiens;
Murine
respirovirus)		5 / 12ARG B 154
GLU B 187
ASP A  65
GLU B 184
TYR B 180
None
1.42A12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPN_A_ZMRA700_1
(NEURAMINIDASE)		5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens)		5 / 12ARG A 929
ASP A 914
ARG A 814
GLU A1034
ARG A1039
None
None
EDO  A1603 (-3.9A)
EDO  A1603 (-2.7A)
EDO  A1603 ( 3.8A)
1.33A15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPN_A_ZMRA700_1
(NEURAMINIDASE)		5fbh EXTRACELLULAR
CALCIUM-SENSING
RECEPTOR
(Homo
sapiens)		5 / 12ASP B  99
GLU B 350
ALA B  26
ASN B 345
TYR B  63
None
1.34A21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPN_A_ZMRA700_1
(NEURAMINIDASE)		6fel 14-3-3 PROTEIN GAMMA
(Homo
sapiens)		5 / 12ARG A  61
GLU A 185
ARG A 132
ASN A 178
ARG A  57
None
1.24A10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPN_B_ZMRB700_1
(NEURAMINIDASE)		2f28 SIALIDASE 2
(Homo
sapiens)		5 / 12ARG A  21
GLU A 218
ARG A 237
ARG A 304
TYR A 334
None
0.43A23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPN_B_ZMRB700_1
(NEURAMINIDASE)		2r4f 3-HYDROXY-3-METHYLGL
UTARYL-COENZYME A
REDUCTASE
(Homo
sapiens)		5 / 12GLU A 482
ARG A 495
ARG A 490
ALA A 459
GLU A 486
None
0.96A21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPN_B_ZMRB700_1
(NEURAMINIDASE)		3wwt PROTEIN C'
SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION
1-ALPHA/BETA
(Homo
sapiens;
Murine
respirovirus)		5 / 12ARG B 154
GLU B 187
ASP A  65
GLU B 184
TYR B 180
None
1.37A12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPN_B_ZMRB700_1
(NEURAMINIDASE)		5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens)		5 / 12ARG A 929
ASP A 914
ARG A 814
GLU A1034
ARG A1039
None
None
EDO  A1603 (-3.9A)
EDO  A1603 (-2.7A)
EDO  A1603 ( 3.8A)
1.36A15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPN_B_ZMRB700_1
(NEURAMINIDASE)		5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens)		5 / 12GLU A 434
ARG A 509
ARG A 388
ALA A 412
GLU A 423
None
1.26A19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_A_ZMRA1471_1
(NEURAMINIDASE)		2f28 SIALIDASE 2
(Homo
sapiens)		5 / 12ARG A  21
GLU A 218
ARG A 237
ARG A 304
TYR A 334
None
0.43A23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_A_ZMRA1471_1
(NEURAMINIDASE)		6fel 14-3-3 PROTEIN GAMMA
(Homo
sapiens)		5 / 12ARG A  61
GLU A 185
ARG A 132
ASN A 178
ARG A  57
None
1.17A10.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_A_ZMRA1471_2
(NEURAMINIDASE)		2buj SERINE/THREONINE-PRO
TEIN KINASE 16
(Homo
sapiens)		4 / 5LEU A  97
ASP A  35
ARG A  50
TRP A  95
None
1.42A19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_A_ZMRA1471_2
(NEURAMINIDASE)		3na0 CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME,
MITOCHONDRIAL
(Homo
sapiens)		4 / 5LEU A 441
ASP A 436
ARG A 439
TRP A 440
None
1.50A19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_A_ZMRA1471_2
(NEURAMINIDASE)		4j0w U3 SMALL NUCLEOLAR
RNA-INTERACTING
PROTEIN 2
(Homo
sapiens)		4 / 5LEU A 415
ASP A 417
ARG A 401
TRP A 403
None
1.37A19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_B_ZMRB1471_1
(NEURAMINIDASE)		2f28 SIALIDASE 2
(Homo
sapiens)		5 / 12ARG A  21
GLU A 218
ARG A 237
ARG A 304
TYR A 334
None
0.40A23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_B_ZMRB1471_1
(NEURAMINIDASE)		6fel 14-3-3 PROTEIN GAMMA
(Homo
sapiens)		5 / 12ARG A  61
GLU A 185
ARG A 132
ASN A 178
ARG A  57
None
1.17A10.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_C_ZMRC1470_1
(NEURAMINIDASE)		2f28 SIALIDASE 2
(Homo
sapiens)		5 / 12ARG A  21
GLU A 218
ARG A 237
ARG A 304
TYR A 334
None
0.40A23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_C_ZMRC1470_1
(NEURAMINIDASE)		3wwt PROTEIN C'
SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION
1-ALPHA/BETA
(Homo
sapiens;
Murine
respirovirus)		5 / 12ARG B 154
GLU B 187
ASP A  65
GLU B 184
TYR B 180
None
1.41A11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_C_ZMRC1470_1
(NEURAMINIDASE)		5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens)		5 / 12ARG A 929
ASP A 914
ARG A 814
GLU A1034
ARG A1039
None
None
EDO  A1603 (-3.9A)
EDO  A1603 (-2.7A)
EDO  A1603 ( 3.8A)
1.28A16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_C_ZMRC1470_1
(NEURAMINIDASE)		6fel 14-3-3 PROTEIN GAMMA
(Homo
sapiens)		5 / 12ARG A  61
GLU A 185
ARG A 132
ASN A 178
ARG A  57
None
1.19A10.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_C_ZMRC1470_2
(NEURAMINIDASE)		1ity TRF1
(Homo
sapiens)		3 / 3ARG A 423
ARG A 380
TRP A 383
None
1.36A10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_C_ZMRC1470_2
(NEURAMINIDASE)		2vd5 DMPK PROTEIN
(Homo
sapiens)		3 / 3ARG A 129
ARG A 210
TRP A 130
None
1.42A22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_C_ZMRC1470_2
(NEURAMINIDASE)		2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens)		3 / 3ARG A 454
ARG A 457
TRP A 472
None
0.76A21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_C_ZMRC1470_2
(NEURAMINIDASE)		3jwe MGLL PROTEIN
(Homo
sapiens)		3 / 3ARG A  43
ARG A  73
TRP A  45
None
1.11A19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_C_ZMRC1470_2
(NEURAMINIDASE)		4kwg ALDEHYDE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens)		3 / 3ARG A  84
ARG A  77
TRP A  76
None
GAI  A 605 ( 4.6A)
None
1.31A22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_C_ZMRC1470_2
(NEURAMINIDASE)		4r7v ARRESTIN
DOMAIN-CONTAINING
PROTEIN 3
(Homo
sapiens)		3 / 3ARG A  52
ARG A 135
TRP A 137
None
1.15A17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_C_ZMRC1470_2
(NEURAMINIDASE)		5fhz ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3
(Homo
sapiens)		3 / 3ARG A  96
ARG A  89
TRP A  88
None
1.25A22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_C_ZMRC1470_2
(NEURAMINIDASE)		5wbs FRIZZLED-7,INHIBITOR
PEPTIDE FZ7-21
(Homo
sapiens)		3 / 3ARG A  98
ARG A 117
TRP A 112
None
1.43A11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_C_ZMRC1470_2
(NEURAMINIDASE)		6b3j GLUCAGON-LIKE
PEPTIDE 1 RECEPTOR
(Homo
sapiens)		3 / 3ARG R  43
ARG R  40
TRP R  39
None
1.42A9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_C_ZMRC1470_2
(NEURAMINIDASE)		6b5i RETINAL
DEHYDROGENASE 2
(Homo
sapiens)		3 / 3ARG A 102
ARG A  95
TRP A  94
None
1.33A9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_D_ZMRD1471_1
(NEURAMINIDASE)		2f28 SIALIDASE 2
(Homo
sapiens)		5 / 12ARG A  21
GLU A 218
ARG A 237
ARG A 304
TYR A 334
None
0.35A23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_D_ZMRD1471_1
(NEURAMINIDASE)		2q0z PROTEIN PRO2281
(Homo
sapiens)		5 / 12GLU X 211
LEU X 277
ARG X 236
GLU X 237
GLU X 238
None
1.45A22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_D_ZMRD1471_1
(NEURAMINIDASE)		6en4 SPLICING FACTOR 3B
SUBUNIT 3
SPLICING FACTOR 3B
SUBUNIT 5
(Homo
sapiens)		5 / 12ARG A 283
GLU B  59
LEU B  50
GLU B  57
ARG A 429
None
1.48A10.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_E_ZMRE1471_1
(NEURAMINIDASE)		2f28 SIALIDASE 2
(Homo
sapiens)		5 / 12ARG A  21
GLU A 218
ARG A 237
ARG A 304
TYR A 334
None
0.43A23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_E_ZMRE1471_1
(NEURAMINIDASE)		2q0z PROTEIN PRO2281
(Homo
sapiens)		5 / 12GLU X 211
LEU X 277
ARG X 236
GLU X 237
GLU X 238
None
1.44A22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_E_ZMRE1471_2
(NEURAMINIDASE)		1ity TRF1
(Homo
sapiens)		3 / 3ARG A 423
ARG A 380
TRP A 383
None
1.38A10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_E_ZMRE1471_2
(NEURAMINIDASE)		2vd5 DMPK PROTEIN
(Homo
sapiens)		3 / 3ARG A 129
ARG A 210
TRP A 130
None
1.49A22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_E_ZMRE1471_2
(NEURAMINIDASE)		2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens)		3 / 3ARG A 454
ARG A 457
TRP A 472
None
0.79A21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_E_ZMRE1471_2
(NEURAMINIDASE)		3jwe MGLL PROTEIN
(Homo
sapiens)		3 / 3ARG A  43
ARG A  73
TRP A  45
None
1.07A19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_E_ZMRE1471_2
(NEURAMINIDASE)		3pta DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens)		3 / 3ARG A1574
ARG A 650
TRP A1170
None
None
SAH  A1601 (-4.9A)
1.18A18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_E_ZMRE1471_2
(NEURAMINIDASE)		4kwg ALDEHYDE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens)		3 / 3ARG A  84
ARG A  77
TRP A  76
None
GAI  A 605 ( 4.6A)
None
1.21A22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_E_ZMRE1471_2
(NEURAMINIDASE)		4r7v ARRESTIN
DOMAIN-CONTAINING
PROTEIN 3
(Homo
sapiens)		3 / 3ARG A  52
ARG A 135
TRP A 137
None
1.07A17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_E_ZMRE1471_2
(NEURAMINIDASE)		5fhz ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3
(Homo
sapiens)		3 / 3ARG A  96
ARG A  89
TRP A  88
None
1.14A22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_E_ZMRE1471_2
(NEURAMINIDASE)		5wbs FRIZZLED-7,INHIBITOR
PEPTIDE FZ7-21
(Homo
sapiens)		3 / 3ARG A  98
ARG A 117
TRP A 112
None
1.36A11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_E_ZMRE1471_2
(NEURAMINIDASE)		6b5i RETINAL
DEHYDROGENASE 2
(Homo
sapiens)		3 / 3ARG A 102
ARG A  95
TRP A  94
None
1.23A9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_F_ZMRF1470_1
(NEURAMINIDASE)		2f28 SIALIDASE 2
(Homo
sapiens)		5 / 12ARG A  21
GLU A 218
ARG A 237
ARG A 304
TYR A 334
None
0.47A23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_F_ZMRF1470_2
(NEURAMINIDASE)		1ity TRF1
(Homo
sapiens)		3 / 3ARG A 423
ARG A 380
TRP A 383
None
1.32A10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_F_ZMRF1470_2
(NEURAMINIDASE)		2vd5 DMPK PROTEIN
(Homo
sapiens)		3 / 3ARG A 129
ARG A 210
TRP A 130
None
1.49A22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_F_ZMRF1470_2
(NEURAMINIDASE)		3jwe MGLL PROTEIN
(Homo
sapiens)		3 / 3ARG A  43
ARG A  73
TRP A  45
None
1.06A19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_F_ZMRF1470_2
(NEURAMINIDASE)		4kwg ALDEHYDE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens)		3 / 3ARG A  84
ARG A  77
TRP A  76
None
GAI  A 605 ( 4.6A)
None
1.26A22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_F_ZMRF1470_2
(NEURAMINIDASE)		4r7v ARRESTIN
DOMAIN-CONTAINING
PROTEIN 3
(Homo
sapiens)		3 / 3ARG A  52
ARG A 135
TRP A 137
None
1.13A17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_F_ZMRF1470_2
(NEURAMINIDASE)		5fhz ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3
(Homo
sapiens)		3 / 3ARG A  96
ARG A  89
TRP A  88
None
1.20A22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_F_ZMRF1470_2
(NEURAMINIDASE)		5wbs FRIZZLED-7,INHIBITOR
PEPTIDE FZ7-21
(Homo
sapiens)		3 / 3ARG A  98
ARG A 117
TRP A 112
None
1.36A11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_F_ZMRF1470_2
(NEURAMINIDASE)		5xtc NADH DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT
5, MITOCHONDRIAL
(Homo
sapiens)		3 / 3ARG a 123
ARG a 119
TRP a 110
None
1.33A14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_F_ZMRF1470_2
(NEURAMINIDASE)		6b5i RETINAL
DEHYDROGENASE 2
(Homo
sapiens)		3 / 3ARG A 102
ARG A  95
TRP A  94
None
1.29A9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_G_ZMRG1471_1
(NEURAMINIDASE)		2f28 SIALIDASE 2
(Homo
sapiens)		5 / 12ARG A  21
GLU A 218
ARG A 237
ARG A 304
TYR A 334
None
0.40A23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_G_ZMRG1471_1
(NEURAMINIDASE)		3tvl THIAMINE-TRIPHOSPHAT
ASE
(Homo
sapiens)		5 / 12ARG A  57
ALA A 192
GLU A   9
GLU A   7
ARG A 125
3PO  A 231 (-3.0A)
3PO  A 231 ( 4.2A)
None
3PO  A 231 ( 4.4A)
3PO  A 231 (-2.9A)
1.36A20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_G_ZMRG1471_1
(NEURAMINIDASE)		5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens)		5 / 12ARG A 929
ASP A 914
ARG A 814
GLU A1034
ARG A1039
None
None
EDO  A1603 (-3.9A)
EDO  A1603 (-2.7A)
EDO  A1603 ( 3.8A)
1.24A16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_G_ZMRG1471_1
(NEURAMINIDASE)		5fbh EXTRACELLULAR
CALCIUM-SENSING
RECEPTOR
(Homo
sapiens)		5 / 12ASP B  99
GLU B 350
ALA B  26
ASN B 345
TYR B  63
None
1.26A21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_G_ZMRG1471_2
(NEURAMINIDASE)		1ity TRF1
(Homo
sapiens)		3 / 3ARG A 423
ARG A 380
TRP A 383
None
1.41A10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_G_ZMRG1471_2
(NEURAMINIDASE)		2vd5 DMPK PROTEIN
(Homo
sapiens)		3 / 3ARG A 129
ARG A 210
TRP A 130
None
1.49A22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_G_ZMRG1471_2
(NEURAMINIDASE)		3jwe MGLL PROTEIN
(Homo
sapiens)		3 / 3ARG A  43
ARG A  73
TRP A  45
None
0.96A19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_G_ZMRG1471_2
(NEURAMINIDASE)		4kwg ALDEHYDE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens)		3 / 3ARG A  84
ARG A  77
TRP A  76
None
GAI  A 605 ( 4.6A)
None
1.20A22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_G_ZMRG1471_2
(NEURAMINIDASE)		4r7v ARRESTIN
DOMAIN-CONTAINING
PROTEIN 3
(Homo
sapiens)		3 / 3ARG A  52
ARG A 135
TRP A 137
None
1.09A17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_G_ZMRG1471_2
(NEURAMINIDASE)		5fhz ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3
(Homo
sapiens)		3 / 3ARG A  96
ARG A  89
TRP A  88
None
1.15A22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_G_ZMRG1471_2
(NEURAMINIDASE)		5wbs FRIZZLED-7,INHIBITOR
PEPTIDE FZ7-21
(Homo
sapiens)		3 / 3ARG A  98
ARG A 117
TRP A 112
None
1.41A11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_G_ZMRG1471_2
(NEURAMINIDASE)		5xtc NADH DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT
5, MITOCHONDRIAL
(Homo
sapiens)		3 / 3ARG a 123
ARG a 119
TRP a 110
None
1.36A14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_G_ZMRG1471_2
(NEURAMINIDASE)		6b5i RETINAL
DEHYDROGENASE 2
(Homo
sapiens)		3 / 3ARG A 102
ARG A  95
TRP A  94
None
1.24A9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_H_ZMRH1470_1
(NEURAMINIDASE)		2f28 SIALIDASE 2
(Homo
sapiens)		5 / 12ARG A  21
GLU A 218
ARG A 237
ARG A 304
TYR A 334
None
0.54A23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_H_ZMRH1470_1
(NEURAMINIDASE)		3wwt PROTEIN C'
SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION
1-ALPHA/BETA
(Homo
sapiens;
Murine
respirovirus)		5 / 12ARG B 154
GLU B 187
ASP A  65
GLU B 184
TYR B 180
None
1.48A11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_H_ZMRH1470_2
(NEURAMINIDASE)		1ity TRF1
(Homo
sapiens)		3 / 3ARG A 423
ARG A 380
TRP A 383
None
1.31A10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_H_ZMRH1470_2
(NEURAMINIDASE)		2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens)		3 / 3ARG A 454
ARG A 457
TRP A 472
None
0.76A21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_H_ZMRH1470_2
(NEURAMINIDASE)		3jwe MGLL PROTEIN
(Homo
sapiens)		3 / 3ARG A  43
ARG A  73
TRP A  45
None
1.12A19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_H_ZMRH1470_2
(NEURAMINIDASE)		4kwg ALDEHYDE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens)		3 / 3ARG A  84
ARG A  77
TRP A  76
None
GAI  A 605 ( 4.6A)
None
1.31A22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_H_ZMRH1470_2
(NEURAMINIDASE)		4r7v ARRESTIN
DOMAIN-CONTAINING
PROTEIN 3
(Homo
sapiens)		3 / 3ARG A  52
ARG A 135
TRP A 137
None
1.19A17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_H_ZMRH1470_2
(NEURAMINIDASE)		5fhz ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3
(Homo
sapiens)		3 / 3ARG A  96
ARG A  89
TRP A  88
None
1.25A22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_H_ZMRH1470_2
(NEURAMINIDASE)		5wbs FRIZZLED-7,INHIBITOR
PEPTIDE FZ7-21
(Homo
sapiens)		3 / 3ARG A  98
ARG A 117
TRP A 112
None
1.39A11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_H_ZMRH1470_2
(NEURAMINIDASE)		6b3j GLUCAGON-LIKE
PEPTIDE 1 RECEPTOR
(Homo
sapiens)		3 / 3ARG R  43
ARG R  40
TRP R  39
None
1.48A9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_H_ZMRH1470_2
(NEURAMINIDASE)		6b5i RETINAL
DEHYDROGENASE 2
(Homo
sapiens)		3 / 3ARG A 102
ARG A  95
TRP A  94
None
1.33A9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I00_A_ZMRA509_1
(NEURAMINIDASE)		1y4j SULFATASE MODIFYING
FACTOR 2
(Homo
sapiens)		5 / 12ARG A  55
GLU A 167
ALA A 173
GLU A 166
ARG A 253
None
1.43A20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I00_A_ZMRA509_1
(NEURAMINIDASE)		2f28 SIALIDASE 2
(Homo
sapiens)		5 / 12ARG A  21
GLU A 218
ARG A 237
ARG A 304
TYR A 334
None
0.39A20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I00_A_ZMRA509_1
(NEURAMINIDASE)		5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens)		5 / 12ARG A 929
ASP A 914
ARG A 814
GLU A1034
ARG A1039
None
None
EDO  A1603 (-3.9A)
EDO  A1603 (-2.7A)
EDO  A1603 ( 3.8A)
1.23A13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I00_A_ZMRA509_2
(NEURAMINIDASE)		1fyh INTERFERON GAMMA
(Homo
sapiens)		4 / 5LEU A  33
ARG A  42
ILE A 244
ASN A  78
None
0.92A19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I00_A_ZMRA509_2
(NEURAMINIDASE)		1fyh INTERFERON GAMMA
(Homo
sapiens)		4 / 5LEU A 233
ARG A 242
ILE A  44
ASN A 278
None
1.20A19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I00_A_ZMRA509_2
(NEURAMINIDASE)		2ckh SENTRIN-SPECIFIC
PROTEASE 1
(Homo
sapiens)		4 / 5LEU A 643
ARG A 632
ILE A 637
ASN A 476
None
1.08A18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I00_A_ZMRA509_2
(NEURAMINIDASE)		2jau 5'(3')-DEOXYRIBONUCL
EOTIDASE
(Homo
sapiens)		4 / 5LEU A 172
TRP A 189
ILE A 180
ASN A 199
None
1.41A18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I00_A_ZMRA509_2
(NEURAMINIDASE)		3pdy PLECTIN
(Homo
sapiens)		4 / 5LEU A 555
TRP A 558
ILE A 592
ASN A 633
None
1.42A18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I00_A_ZMRA509_2
(NEURAMINIDASE)		4gl2 INTERFERON-INDUCED
HELICASE C
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens)		4 / 5LEU A 809
ARG A 806
ILE A 814
ASN A 364
None
1.37A17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I00_A_ZMRA509_2
(NEURAMINIDASE)		4yc7 FORMIN-LIKE PROTEIN
2
(Homo
sapiens)		4 / 5LEU B 284
ARG B 299
ILE B 324
ASN B 374
None
1.20A19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I00_A_ZMRA509_2
(NEURAMINIDASE)		5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens)		4 / 5LEU C 773
TRP C 776
ILE C 792
ASN C 869
None
1.30A6.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I00_A_ZMRA509_2
(NEURAMINIDASE)		5y7y ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR
ARYL HYDROCARBON
RECEPTOR REPRESSOR
(Bos
taurus;
Homo
sapiens)		4 / 5LEU A 248
TRP A 177
ILE B 458
ASN B 461
None
1.14A19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWR_A_ZMRA513_1
(NEURAMINIDASE)		1y4j SULFATASE MODIFYING
FACTOR 2
(Homo
sapiens)		5 / 12ARG A  55
GLU A 167
ALA A 173
GLU A 166
ARG A 253
None
1.45A20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWR_A_ZMRA513_1
(NEURAMINIDASE)		2f28 SIALIDASE 2
(Homo
sapiens)		5 / 12ARG A  21
GLU A 218
ARG A 237
ARG A 304
TYR A 334
None
0.42A21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWR_A_ZMRA513_1
(NEURAMINIDASE)		4b9d SERINE/THREONINE-PRO
TEIN KINASE NEK1
(Homo
sapiens)		5 / 12GLU A  25
GLU A  68
GLU A   2
ARG A  67
ARG A  28
None
1.29A21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWR_A_ZMRA513_1
(NEURAMINIDASE)		4mel UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 11
(Homo
sapiens)		5 / 12GLU A  71
GLU A  50
GLU A  43
ARG A  49
TYR A  67
None
1.34A20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWR_A_ZMRA513_1
(NEURAMINIDASE)		5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens)		5 / 12GLU A 434
ARG A 509
ARG A 388
ALA A 412
GLU A 423
None
1.37A20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWR_A_ZMRA513_1
(NEURAMINIDASE)		6fel 14-3-3 PROTEIN GAMMA
(Homo
sapiens)		5 / 12ARG A  61
GLU A 185
ARG A 132
ASN A 178
ARG A  57
None
1.13A10.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWR_A_ZMRA513_2
(NEURAMINIDASE)		1p22 F-BOX/WD-REPEAT
PROTEIN 1A
(Homo
sapiens)		4 / 5LEU A 515
ASP A 545
ARG A 254
ILE A 246
None
1.23A21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWR_A_ZMRA513_2
(NEURAMINIDASE)		1uw0 DNA LIGASE III
(Homo
sapiens)		4 / 5LEU A  82
ASP A   9
ARG A  31
ILE A  25
None
1.40A13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWR_A_ZMRA513_2
(NEURAMINIDASE)		2buj SERINE/THREONINE-PRO
TEIN KINASE 16
(Homo
sapiens)		4 / 5LEU A  97
ASP A  35
ARG A  50
TRP A  95
None
1.47A19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWR_A_ZMRA513_2
(NEURAMINIDASE)		2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens)		4 / 5LEU A 463
ASP A 465
TRP A 467
ILE A 514
None
1.43A21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWR_A_ZMRA513_2
(NEURAMINIDASE)		3na0 CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME,
MITOCHONDRIAL
(Homo
sapiens)		4 / 5LEU A 441
ASP A 436
ARG A 439
TRP A 440
None
1.49A19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWR_A_ZMRA513_2
(NEURAMINIDASE)		3p8c ABL INTERACTOR 2
NCK-ASSOCIATED
PROTEIN 1
(Homo
sapiens)		4 / 5LEU B 143
ASP B  99
ARG B  23
ILE F 141
None
1.47A17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWR_A_ZMRA513_2
(NEURAMINIDASE)		4i1f E3 UBIQUITIN-PROTEIN
LIGASE PARKIN
(Homo
sapiens)		4 / 5LEU A 176
ASP A 185
ARG A 191
ILE A 188
None
1.46A20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWR_A_ZMRA513_2
(NEURAMINIDASE)		4u0q BASIGIN
(Homo
sapiens)		4 / 5LEU B 150
ASP B 147
ARG B 184
ILE B 197
None
1.36A20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWR_A_ZMRA513_2
(NEURAMINIDASE)		5vhi 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT 2
(Homo
sapiens)		4 / 5LEU f 560
ASP f 784
ARG f 785
ILE f 660
None
1.17A18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWR_A_ZMRA513_2
(NEURAMINIDASE)		5xv7 SERINE-ARGININE (SR)
PROTEIN KINASE 1
(Homo
sapiens)		4 / 5LEU A  69
ASP A  74
TRP A  95
ILE A  72
None
1.46A12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWR_A_ZMRA513_2
(NEURAMINIDASE)		6g4q SUCCINATE--COA
LIGASE [ADP-FORMING]
SUBUNIT BETA,
MITOCHONDRIAL
(Homo
sapiens)		4 / 5LEU B  90
ASP B  94
ARG B 160
ILE B 121
None
1.24A11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWX_A_ZMRA513_1
(NEURAMINIDASE)		5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens)		5 / 12GLU A 434
ARG A 509
ARG A 388
ALA A 412
GLU A 423
None
1.42A20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWX_A_ZMRA513_2
(NEURAMINIDASE)		1e41 FADD PROTEIN
(Homo
sapiens)		3 / 3ARG A 113
TRP A 112
ILE A 126
None
0.55A14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWX_A_ZMRA513_2
(NEURAMINIDASE)		2qfz TBC1 DOMAIN FAMILY
MEMBER 22A
(Homo
sapiens)		3 / 3ARG A 228
TRP A 232
ILE A 436
None
0.96A18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWX_A_ZMRA513_2
(NEURAMINIDASE)		5c5b DCC-INTERACTING
PROTEIN 13-ALPHA
(Homo
sapiens)		3 / 3ARG A 287
TRP A 297
ILE A 354
None
0.83A21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWX_A_ZMRA513_2
(NEURAMINIDASE)		5c5b DCC-INTERACTING
PROTEIN 13-BETA
(Homo
sapiens)		3 / 3ARG B 287
TRP B 297
ILE B 354
None
0.72A20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWX_A_ZMRA513_2
(NEURAMINIDASE)		5fhh ATP-DEPENDENT DNA
HELICASE PIF1
(Homo
sapiens)		3 / 3ARG A 327
TRP A 297
ILE A 336
None
1.11A21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWX_A_ZMRA513_2
(NEURAMINIDASE)		5k1b WD REPEAT-CONTAINING
PROTEIN 48
(Homo
sapiens)		3 / 3ARG B 476
TRP B 474
ILE B 551
None
1.07A20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWX_A_ZMRA513_2
(NEURAMINIDASE)		5k1c WD REPEAT-CONTAINING
PROTEIN 48
(Homo
sapiens)		3 / 3ARG B 476
TRP B 474
ILE B 551
None
1.09A18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWX_A_ZMRA513_2
(NEURAMINIDASE)		5u77 OXYSTEROL-BINDING
PROTEIN-RELATED
PROTEIN 8
(Homo
sapiens)		3 / 3ARG A  18
TRP A  24
ILE A 104
None
0.77A15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWX_A_ZMRA513_2
(NEURAMINIDASE)		6d0s TBC1 DOMAIN FAMILY
MEMBER 22B
(Homo
sapiens)		3 / 3ARG A 216
TRP A 220
ILE A 424
UNX  A 611 ( 4.2A)
None
None
0.94A14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWX_A_ZMRA513_2
(NEURAMINIDASE)		6gmb HYDROXYACID OXIDASE
1
(Homo
sapiens)		3 / 3ARG A 137
TRP A 224
ILE A 133
None
1.04A10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA5_A_ZMRA501_1
(NEURAMINIDASE)		2d2z CHLORIDE
INTRACELLULAR
CHANNEL PROTEIN 4
(Homo
sapiens)		5 / 12GLU A  93
ALA A 187
GLU A  92
ARG A  40
ASN A 190
None
1.50A21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA5_A_ZMRA501_1
(NEURAMINIDASE)		2f28 SIALIDASE 2
(Homo
sapiens)		5 / 12ARG A  21
GLU A 218
ARG A 237
ARG A 304
TYR A 334
None
0.42A21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA5_A_ZMRA501_1
(NEURAMINIDASE)		4mel UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 11
(Homo
sapiens)		5 / 12GLU A  71
GLU A  50
GLU A  43
ARG A  49
TYR A  67
None
1.41A20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA5_A_ZMRA501_1
(NEURAMINIDASE)		6fel 14-3-3 PROTEIN GAMMA
(Homo
sapiens)		5 / 12ARG A  61
GLU A 185
ARG A 132
ASN A 178
ARG A  57
None
1.14A12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L17_A_ZMRA512_1
(NEURAMINIDASE)		2f28 SIALIDASE 2
(Homo
sapiens)		5 / 12ARG A  21
GLU A 218
ARG A 237
ARG A 304
TYR A 334
None
0.42A22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L17_A_ZMRA512_1
(NEURAMINIDASE)		4mel UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 11
(Homo
sapiens)		5 / 12GLU A  71
GLU A  50
GLU A  43
ARG A  49
TYR A  67
None
1.38A20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L17_A_ZMRA512_1
(NEURAMINIDASE)		5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens)		5 / 12GLU A 434
ARG A 509
ARG A 388
ALA A 412
GLU A 423
None
1.42A20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_1
(SIALIDASE)		2f28 SIALIDASE 2
(Homo
sapiens)		7 / 12ARG A  21
ILE A  22
GLU A  39
GLU A 218
ARG A 237
ARG A 304
TYR A 334
None
0.44A19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_1
(SIALIDASE)		5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens)		5 / 12ILE C2933
ARG C2922
PRO C2918
ASP C2937
ARG C3901
None
1.19A10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_2
(SIALIDASE)		1lw3 MYOTUBULARIN-RELATED
PROTEIN 2
(Homo
sapiens)		4 / 6ASN A 545
LEU A 540
SER A 539
PHE A 520
None
1.10A20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_2
(SIALIDASE)		1ryo SEROTRANSFERRIN
(Homo
sapiens)		4 / 6ASP A 138
ASN A 230
LEU A 226
PHE A 204
None
1.10A17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_2
(SIALIDASE)		1zsq MYOTUBULARIN-RELATED
PROTEIN 2
(Homo
sapiens)		4 / 6ASN A 545
LEU A 540
SER A 539
PHE A 520
None
1.13A21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_2
(SIALIDASE)		2dh3 4F2 CELL-SURFACE
ANTIGEN HEAVY CHAIN
(Homo
sapiens)		4 / 6ASP A 439
LEU A 488
SER A 487
PHE A 525
 ZN  A 601 (-2.2A)
None
None
None
1.02A20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_2
(SIALIDASE)		4fo0 ACTIN-RELATED
PROTEIN 8
(Homo
sapiens)		4 / 6ASP A 520
ASN A 302
LEU A 408
PHE A 504
None
1.11A22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_2
(SIALIDASE)		4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA
(Homo
sapiens)		4 / 6GLN A 139
ASN A  88
LEU A 135
SER A 132
None
1.15A15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_2
(SIALIDASE)		4nge PRESEQUENCE
PROTEASE,
MITOCHONDRIAL
(Homo
sapiens)		4 / 6ASP D 377
GLN D 219
ASN D 223
SER D 235
None
1.26A21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_2
(SIALIDASE)		4o3m BLOOM SYNDROME
PROTEIN
(Homo
sapiens)		4 / 6GLN A 838
LEU A 688
SER A 854
PHE A 686
None
1.15A20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_2
(SIALIDASE)		4qam X-LINKED RETINITIS
PIGMENTOSA GTPASE
REGULATOR-INTERACTIN
G PROTEIN 1
(Homo
sapiens)		4 / 6ASP B1242
GLN B1246
LEU B1248
PHE B1209
None
1.06A14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_2
(SIALIDASE)		4qtb MITOGEN-ACTIVATED
PROTEIN KINASE 3
(Homo
sapiens)		4 / 6GLN A 136
LEU A 138
SER A 139
PHE A 146
None
0.91A19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_2
(SIALIDASE)		4uad IMPORTIN SUBUNIT
ALPHA-7
(Homo
sapiens)		4 / 6ASP A 182
GLN A 184
LEU A 217
SER A 221
None
0.84A20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_2
(SIALIDASE)		5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens)		4 / 6ASP A1154
ASN A1192
LEU A1176
PHE A1175
None
1.08A19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_2
(SIALIDASE)		5c16 MYOTUBULARIN-RELATED
PROTEIN 1
(Homo
sapiens)		4 / 6ASN A 566
LEU A 561
SER A 560
PHE A 541
None
1.18A21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_2
(SIALIDASE)		5ir3 IG LAMBDA CHAIN V-VI
REGION AR
(Homo
sapiens)		4 / 6ASP A  69
LEU A   4
SER A  93
PHE A   2
None
1.26A10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_2
(SIALIDASE)		5liy ALDO-KETO REDUCTASE
FAMILY 1 MEMBER B10
(Homo
sapiens)		4 / 6ASP X  99
GLN X  50
LEU X 122
PHE X  83
MLY  X  95 ( 2.7A)
None
None
None
1.26A18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_2
(SIALIDASE)		5n4w CULLIN-2
(Homo
sapiens)		4 / 6ASP A 675
GLN A 432
LEU A 473
SER A 471
None
1.10A21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_2
(SIALIDASE)		5n7f MEMBRANE-ASSOCIATED
GUANYLATE KINASE, WW
AND PDZ
DOMAIN-CONTAINING
PROTEIN 1,ANNEXIN A2
(Homo
sapiens)		4 / 6ASP A 815
GLN A 800
ASN A 797
LEU A 780
None
1.13A20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCX_A_ZMRA519_0
(NEURAMINIDASE)		5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens)		5 / 12GLU A 434
ARG A 509
ARG A 388
ALA A 412
GLU A 423
None
1.38A15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCX_A_ZMRA519_1
(NEURAMINIDASE)		3vpo RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT M2
(Homo
sapiens)		3 / 3TRP A 116
ILE A 127
GLU A 122
None
0.83A14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCX_A_ZMRA519_1
(NEURAMINIDASE)		3wsy SORTILIN-RELATED
RECEPTOR
(Homo
sapiens)		3 / 3TRP A 530
ILE A 504
GLU A 567
None
0.81A8.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCX_A_ZMRA519_1
(NEURAMINIDASE)		3x05 PHOSPHATIDYLINOSITOL
5-PHOSPHATE 4-KINASE
TYPE-2 BETA
(Homo
sapiens)		3 / 3TRP A  48
ILE A  77
GLU A  97
None
0.80A11.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCX_A_ZMRA519_1
(NEURAMINIDASE)		4hs2 SPECKLE-TYPE POZ
PROTEIN
(Homo
sapiens)		3 / 3TRP A 338
ILE A 325
GLU A 351
None
0.81A17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCX_A_ZMRA519_1
(NEURAMINIDASE)		4o3m BLOOM SYNDROME
PROTEIN
(Homo
sapiens)		3 / 3TRP A 934
ILE A 953
GLU A 976
None
0.75A8.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCX_A_ZMRA519_1
(NEURAMINIDASE)		4xey TYROSINE-PROTEIN
KINASE ABL1
(Homo
sapiens)		3 / 3TRP B 280
ILE B 333
GLU B 255
None
0.81A10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCX_A_ZMRA519_1
(NEURAMINIDASE)		5gje LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 6
(Homo
sapiens)		3 / 3TRP B1030
ILE B1014
GLU B1033
None
0.76A9.32