POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		1adq IGM-LAMBDA RF-AN FAB
(HEAVY CHAIN)
(Homo
sapiens)		5 / 8LEU H 108
GLY H  10
VAL H 109
ALA H  88
GLY H 106
None
1.13A22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		1b41 ACETYLCHOLINESTERASE
(Homo
sapiens)		5 / 8LEU A 418
GLY A 416
ALA A 423
LEU A 324
GLY A 319
None
1.09A19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		1b6u P58 KILLER CELL
INHIBITORY RECEPTOR
(Homo
sapiens)		5 / 8LEU A 166
GLY A 167
VAL A 124
ALA A 112
GLY A 172
None
1.22A20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		1htj KIAA0380
(Homo
sapiens)		5 / 8LEU F 401
GLY F 399
VAL F 400
LEU F 369
GLY F 361
None
1.06A21.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		1k2p TYROSINE-PROTEIN
KINASE BTK
(Homo
sapiens)		5 / 8VAL A 416
ALA A 428
MET A 477
GLY A 480
CYH A 481
None
0.54A33.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		1nfi I-KAPPA-B-ALPHA
(Homo
sapiens)		5 / 8LEU E 163
GLY E 161
VAL E 162
ALA E 127
LEU E 115
None
1.10A21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		1o5f SERINE PROTEASE
HEPSIN
(Homo
sapiens)		5 / 8LEU H  83
GLY H  84
VAL H  66
ALA H  68
GLY H  49
None
1.13A20.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		1rjb FL CYTOKINE RECEPTOR
(Homo
sapiens)		5 / 8LEU A 616
GLY A 617
VAL A 624
ALA A 642
GLY A 697
None
0.66A32.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		1rxt GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE 1
(Homo
sapiens)		5 / 8LEU A 261
GLY A 260
VAL A 316
LEU A 327
MET A 381
None
1.04A21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		1s9i DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 2
(Homo
sapiens)		6 / 8LEU A  78
GLY A  79
VAL A  86
ALA A  99
MET A 150
GLY A 153
ATP  A 535 (-3.9A)
ATP  A 535 ( 3.9A)
ATP  A 535 (-4.1A)
ATP  A 535 (-3.6A)
None
ATP  A 535 ( 4.7A)
0.56A25.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		1snx TYROSINE-PROTEIN
KINASE ITK/TSK
(Homo
sapiens)		5 / 8GLY A 370
VAL A 377
ALA A 389
MET A 438
GLY A 441
None
0.70A32.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		1so8 3-HYDROXYACYL-COA
DEHYDROGENASE TYPE
II
(Homo
sapiens)		5 / 8LEU A  24
GLY A  21
ALA A  27
LEU A  54
GLY A  47
None
NA  A 302 ( 4.3A)
None
None
None
0.80A21.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG
(Homo
sapiens)		5 / 8LEU A 595
GLY A 596
VAL A 603
ALA A 621
GLY A 676
STI  A   3 ( 3.8A)
None
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 ( 3.8A)
0.49A31.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens)		5 / 8LEU A 344
GLY A 345
VAL A 352
ALA A 367
GLY A 418
STU  A 100 (-3.8A)
STU  A 100 (-3.3A)
STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
STU  A 100 ( 4.7A)
1.17A33.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens)		5 / 8LEU A 344
GLY A 345
VAL A 352
ALA A 367
GLY A 420
STU  A 100 (-3.8A)
STU  A 100 (-3.3A)
STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
STU  A 100 (-3.5A)
0.67A33.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		1ua2 CELL DIVISION
PROTEIN KINASE 7
(Homo
sapiens)		5 / 8LEU A  18
GLY A  19
VAL A  26
ALA A  39
MET A  94
ATP  A 381 (-4.4A)
ATP  A 381 ( 3.9A)
ATP  A 381 (-4.0A)
ATP  A 381 (-3.6A)
None
0.45A23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens)		5 / 8LEU A  15
GLY A  16
VAL A  23
ALA A  36
GLY A  90
HYM  A 400 (-4.2A)
HYM  A 400 ( 3.8A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
None
0.81A25.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		1zws DAP-KINASE RELATED
PROTEIN 1
(Homo
sapiens)		5 / 8LEU A  19
GLY A  20
VAL A  27
ALA A  40
LEU A  95
None
0.72A26.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens)		5 / 8LEU A  19
GLY A  20
VAL A  27
LEU A  95
GLY A  99
None
0.99A25.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		2ac5 MAP
KINASE-INTERACTING
SERINE/THREONINE
KINASE 2
(Homo
sapiens)		5 / 8GLY A  91
VAL A  98
ALA A 111
MET A 162
GLY A 165
None
0.85A25.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		2bex RIBONUCLEASE
INHIBITOR
(Homo
sapiens)		5 / 8LEU A 189
GLY A 185
VAL A 188
ALA A 162
LEU A 165
None
1.23A21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		2buj SERINE/THREONINE-PRO
TEIN KINASE 16
(Homo
sapiens)		5 / 8LEU A  26
GLY A  27
VAL A  34
ALA A  47
GLY A 104
STU  A1301 (-4.2A)
STU  A1301 ( 3.8A)
STU  A1301 (-4.8A)
STU  A1301 (-3.6A)
STU  A1301 ( 4.0A)
0.67A23.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN
(Homo
sapiens)		6 / 8LEU X  17
GLY X  18
VAL X  25
ALA X  37
MET X  85
GLY X  88
STU  X 902 (-3.8A)
STU  X 902 ( 3.7A)
STU  X 902 ( 4.8A)
STU  X 902 (-3.1A)
None
STU  X 902 (-3.5A)
0.63A33.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		2dyl DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 7
(Homo
sapiens)		5 / 8VAL A 150
ALA A 163
LEU A 214
MET A 215
CYH A 218
None
0.70A26.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		2e63 KIAA1787 PROTEIN
(Homo
sapiens)		5 / 8LEU A 108
VAL A 100
ALA A 147
GLY A 144
CYH A 143
None
1.25A18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3
(Homo
sapiens)		5 / 8LEU A 162
GLY A 163
VAL A 170
ALA A 184
LEU A 238
None
0.65A23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		2f57 SERINE/THREONINE-PRO
TEIN KINASE PAK 7
(Homo
sapiens)		5 / 8LEU A 584
VAL A 506
ALA A 555
LEU A 556
CYH A 590
None
1.22A23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens)		6 / 8LEU A 273
GLY A 274
VAL A 281
ALA A 293
MET A 341
GLY A 344
H8H  A 534 (-3.8A)
H8H  A 534 ( 3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
None
H8H  A 534 (-3.3A)
0.42A22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens)		6 / 8LEU A 273
GLY A 274
VAL A 281
ALA A 293
MET A 341
GLY A 344
QUE  A   1 (-3.9A)
QUE  A   1 ( 4.2A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-3.0A)
0.64A26.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens)		6 / 8LEU A 251
GLY A 252
VAL A 259
ALA A 271
MET A 319
GLY A 322
1BM  A 499 ( 3.7A)
None
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
None
1BM  A 499 (-3.5A)
0.43A34.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		2hw6 MAP
KINASE-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 1
(Homo
sapiens)		5 / 8LEU A  55
GLY A  56
VAL A  63
ALA A  76
GLY A 130
None
0.55A21.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1
(Homo
sapiens)		6 / 8LEU A 248
GLY A 249
VAL A 256
ALA A 269
MET A 318
GLY A 321
GIN  A 600 ( 4.6A)
None
GIN  A 600 ( 4.7A)
GIN  A 600 (-3.1A)
None
None
0.64A36.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		2jam CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1G
(Homo
sapiens)		5 / 8LEU A  29
GLY A  30
VAL A  37
ALA A  50
LEU A 100
J60  A1305 (-3.9A)
None
J60  A1305 (-4.8A)
J60  A1305 (-3.3A)
J60  A1305 (-4.4A)
0.38A27.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		2jc6 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1D
(Homo
sapiens)		5 / 8LEU A  29
GLY A  30
VAL A  37
ALA A  50
LEU A 100
QPP  A1314 (-3.7A)
QPP  A1314 ( 3.7A)
QPP  A1314 ( 4.6A)
QPP  A1314 ( 3.7A)
QPP  A1314 (-4.5A)
0.39A27.25