POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW7_A_VPXA2001_1
(PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME)		2odp COMPLEMENT C2
(Homo
sapiens)		5 / 12LEU A 727
LEU A 676
LEU A 712
ALA A 486
ALA A 485
None
1.17A20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW7_A_VPXA2001_1
(PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME)		3mtl CELL DIVISION
PROTEIN KINASE 16
(Homo
sapiens)		5 / 12LEU A 415
LEU A 427
PHE A 445
LEU A 270
LEU A 267
None
1.06A22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW7_A_VPXA2001_1
(PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME)		3n00 REV-ERBA-ALPHA
(Homo
sapiens)		5 / 12LEU A 592
LEU A 527
PHE A 585
LEU A 570
ALA A 293
None
1.07A21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW7_A_VPXA2001_1
(PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME)		4omj SEC14-LIKE PROTEIN 2
(Homo
sapiens)		5 / 12TYR A 153
LEU A 189
PHE A 198
ALA A 167
TYR A 171
2TX  A 310 (-4.3A)
2TX  A 310 (-4.8A)
2TX  A 310 (-4.7A)
2TX  A 310 (-3.9A)
2TX  A 310 (-4.1A)
1.17A18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW7_A_VPXA2001_1
(PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME)		4yl6 MALCAVERNIN
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 3
(Homo
sapiens)		5 / 12LEU A 338
LEU A 310
LEU A 299
LEU B  14
TYR A 302
None
1.12A11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW7_A_VPXA2001_1
(PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME)		5mvd DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL
(Homo
sapiens)		5 / 12LEU A  67
PHE A  37
LEU A  42
TYR A  38
ALA A  55
None
None
None
None
U91  A 403 (-3.6A)
1.01A21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW7_A_VPXA2001_1
(PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME)		5ndz LYSOZYME,PROTEINASE-
ACTIVATED RECEPTOR
2,SOLUBLE CYTOCHROME
B562,PROTEINASE-ACTI
VATED RECEPTOR 2
(Escherichia
coli;
Escherichia
virus
T4;
Homo
sapiens)		5 / 12TYR A 160
HIS A 227
LEU A 306
LEU A 307
TYR A 326
None
1.12A28.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW7_A_VPXA2001_1
(PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME)		5ndz LYSOZYME,PROTEINASE-
ACTIVATED RECEPTOR
2,SOLUBLE CYTOCHROME
B562,PROTEINASE-ACTI
VATED RECEPTOR 2
(Escherichia
coli;
Escherichia
virus
T4;
Homo
sapiens)		5 / 12TYR A 160
PHE A 243
LEU A 306
LEU A 307
TYR A 311
None
1.05A28.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW7_A_VPXA2001_1
(PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME)		5nh1 GASDERMIN-D
(Homo
sapiens)		5 / 12LEU A 479
LEU A 320
LEU A 353
ALA A 328
ALA A 332
None
1.09A18.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3VW7_A_VPXA2001_1
(PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME)		5nj6 PROTEINASE-ACTIVATED
RECEPTOR 2,SOLUBLE
CYTOCHROME
B562,PROTEINASE-ACTI
VATED RECEPTOR 2
(Escherichia
coli;
Homo
sapiens)		6 / 12TYR A 156
TYR A 160
LEU A 209
HIS A 227
LEU A 307
TYR A 326
None
1.33A34.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3VW7_A_VPXA2001_1
(PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME)		5nj6 PROTEINASE-ACTIVATED
RECEPTOR 2,SOLUBLE
CYTOCHROME
B562,PROTEINASE-ACTI
VATED RECEPTOR 2
(Escherichia
coli;
Homo
sapiens)		6 / 12TYR A 156
TYR A 160
LEU A 209
LEU A 230
LEU A 307
TYR A 326
None
1.39A34.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3VW7_A_VPXA2001_1
(PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME)		5nj6 PROTEINASE-ACTIVATED
RECEPTOR 2,SOLUBLE
CYTOCHROME
B562,PROTEINASE-ACTI
VATED RECEPTOR 2
(Escherichia
coli;
Homo
sapiens)		6 / 12TYR A 160
LEU A 209
HIS A 227
LEU A 306
LEU A 307
TYR A 326
None
1.21A34.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3VW7_A_VPXA2001_1
(PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME)		5nj6 PROTEINASE-ACTIVATED
RECEPTOR 2,SOLUBLE
CYTOCHROME
B562,PROTEINASE-ACTI
VATED RECEPTOR 2
(Escherichia
coli;
Homo
sapiens)		5 / 12TYR A 160
PHE A 243
LEU A 306
LEU A 307
TYR A 311
None
1.09A34.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW7_A_VPXA2001_2
(PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME)		2c11 MEMBRANE COPPER
AMINE OXIDASE
(Homo
sapiens)		4 / 4PRO A 686
LEU A 516
HIS A 242
LEU A 229
None
1.24A20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW7_A_VPXA2001_2
(PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME)		5vdk WEE1-LIKE PROTEIN
KINASE 2
(Homo
sapiens)		4 / 4PRO A 413
LEU A 338
HIS A 258
LEU A 257
None
1.28A21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW7_A_VPXA2001_2
(PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME)		6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)
(Homo
sapiens)		4 / 4PRO A1247
LEU A1238
HIS A1079
LEU A1007
None
1.21A0.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW7_A_VPXA2001_2
(PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME)		6f9n CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
SUBUNIT 1
(Homo
sapiens)		4 / 4PRO A 483
LEU A1005
HIS A 964
LEU A 963
None
1.39A16.67