POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UHO_A_VDNA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		1soj CGMP-INHIBITED
3',5'-CYCLIC
PHOSPHODIESTERASE B
(Homo
sapiens)		5 / 10TYR A 736
HIS A 737
PHE A 959
GLN A 988
PHE A 991
IBM  A2111 (-4.5A)
IBM  A2111 ( 4.8A)
None
IBM  A2111 (-3.3A)
IBM  A2111 (-3.6A)
0.31A24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UHO_A_VDNA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens)		6 / 10TYR A 211
HIS A 212
PHE A 384
GLN A 413
GLY A 415
PHE A 416
IBM  A 503 (-4.6A)
None
IBM  A 503 (-4.5A)
IBM  A 503 (-3.0A)
None
IBM  A 503 (-3.4A)
0.62A28.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UHO_A_VDNA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens)		6 / 10TYR A 211
HIS A 212
PHE A 384
LEU A 401
GLN A 413
PHE A 416
IBM  A 503 (-4.6A)
None
IBM  A 503 (-4.5A)
None
IBM  A 503 (-3.0A)
IBM  A 503 (-3.4A)
0.76A28.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UHO_A_VDNA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens)		5 / 10TYR A 211
HIS A 216
GLN A 413
GLY A 415
PHE A 416
IBM  A 503 (-4.6A)
ZN  A 501 (-3.3A)
IBM  A 503 (-3.0A)
None
IBM  A 503 (-3.4A)
1.43A28.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UHO_A_VDNA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		2qyk CYCLIC AMP-SPECIFIC
PHOSPHODIESTERASE
HSPDE4A10
(Homo
sapiens)		6 / 10TYR A 371
HIS A 372
PHE A 552
GLN A 581
GLY A 583
PHE A 584
NPV  A   3 (-4.4A)
NPV  A   3 (-4.6A)
NPV  A   3 (-4.8A)
NPV  A   3 (-3.1A)
None
NPV  A   3 (-3.3A)
0.40A29.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UHO_A_VDNA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		3b2r CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens)		8 / 10TYR A 612
HIS A 613
ALA A 783
PHE A 786
MET A 816
GLN A 817
GLY A 819
PHE A 820
VDN  A   1 (-4.8A)
VDN  A   1 (-4.3A)
VDN  A   1 ( 4.0A)
None
VDN  A   1 (-4.0A)
VDN  A   1 (-3.0A)
VDN  A   1 ( 4.1A)
VDN  A   1 (-3.6A)
0.42A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UHO_A_VDNA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		3bjc CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens)		7 / 10TYR A 612
HIS A 613
ALA A 783
PHE A 786
GLN A 817
GLY A 819
PHE A 820
None
MG  A 877 (-4.4A)
WAN  A 901 (-3.6A)
WAN  A 901 (-4.8A)
WAN  A 901 (-3.1A)
None
WAN  A 901 (-3.7A)
0.36A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UHO_A_VDNA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		3bjc CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens)		7 / 10TYR A 612
HIS A 613
PHE A 786
MET A 816
GLN A 817
GLY A 819
PHE A 820
None
MG  A 877 (-4.4A)
WAN  A 901 (-4.8A)
WAN  A 901 (-4.3A)
WAN  A 901 (-3.1A)
None
WAN  A 901 (-3.7A)
0.72A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UHO_A_VDNA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		3bjc CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens)		5 / 10TYR A 612
HIS A 617
GLN A 817
GLY A 819
PHE A 820
None
ZN  A 876 (-3.3A)
WAN  A 901 (-3.1A)
None
WAN  A 901 (-3.7A)
1.42A100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UHO_A_VDNA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		3c5n TUBBY-RELATED
PROTEIN 1
(Homo
sapiens)		5 / 10TYR A 297
ALA A 476
PHE A 475
LEU A 273
GLY A 454
None
1.31A19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UHO_A_VDNA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens)		6 / 10TYR A 325
HIS A 326
PHE A 506
GLN A 535
GLY A 537
PHE A 538
None
D71  A 901 (-4.5A)
D71  A 901 (-4.8A)
D71  A 901 (-3.1A)
None
D71  A 901 (-3.9A)
0.51A26.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UHO_A_VDNA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		3o57 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens)		6 / 10TYR A 233
HIS A 234
PHE A 414
GLN A 443
GLY A 445
PHE A 446
None
None
ZG2  A 506 (-4.4A)
ZG2  A 506 (-3.3A)
ZG2  A 506 (-3.9A)
ZG2  A 506 (-3.6A)
0.48A28.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UHO_A_VDNA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		3pua PHD FINGER PROTEIN 2
(Homo
sapiens)		5 / 10TYR A 221
HIS A 376
ALA A 369
MET A 346
GLN A 345
None
1.31A20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UHO_A_VDNA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens)		6 / 10TYR A 159
HIS A 160
PHE A 340
GLN A 369
GLY A 371
PHE A 372
TYR  A 159 (-1.3A)
HIS  A 160 ( 1.0A)
PHE  A 340 (-1.3A)
GLN  A 369 (-0.6A)
GLY  A 371 ( 0.0A)
PHE  A 372 (-1.3A)
0.37A28.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UHO_A_VDNA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		3ui7 CAMP AND
CAMP-INHIBITED CGMP
3',5'-CYCLIC
PHOSPHODIESTERASE
10A
(Homo
sapiens)		5 / 10TYR A 524
HIS A 525
ALA A 689
GLY A 728
PHE A 729
C1L  A   1 ( 4.8A)
C1L  A   1 (-4.1A)
None
None
C1L  A   1 (-3.5A)
1.27A39.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UHO_A_VDNA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		3ui7 CAMP AND
CAMP-INHIBITED CGMP
3',5'-CYCLIC
PHOSPHODIESTERASE
10A
(Homo
sapiens)		6 / 10TYR A 524
HIS A 525
PHE A 696
GLN A 726
GLY A 728
PHE A 729
C1L  A   1 ( 4.8A)
C1L  A   1 (-4.1A)
C1L  A   1 ( 4.7A)
C1L  A   1 (-2.9A)
None
C1L  A   1 (-3.5A)
0.44A39.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UHO_A_VDNA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		4bla MALTOSE-BINDING
PERIPLASMIC PROTEIN,
SUPPRESSOR OF FUSED
HOMOLOG
(Escherichia
coli;
Homo
sapiens)		5 / 10ALA A 265
PHE A  68
LEU A  77
GLY A  57
PHE A  48
None
1.40A18.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UHO_A_VDNA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens)		5 / 10TYR A 655
HIS A 656
PHE A 830
GLN A 859
PHE A 862
None
0.21A35.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UHO_A_VDNA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens)		6 / 10TYR A 405
HIS A 406
PHE A 586
GLN A 615
GLY A 617
PHE A 618
None
MG  A 804 ( 4.9A)
None
None
None
None
0.42A22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UHO_A_VDNA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		5b25 CALCIUM/CALMODULIN-D
EPENDENT
3',5'-CYCLIC
NUCLEOTIDE
PHOSPHODIESTERASE 1B
(Homo
sapiens)		6 / 10TYR A 222
HIS A 223
PHE A 392
GLN A 421
GLY A 423
PHE A 424
None
4QJ  A 603 ( 4.9A)
GOL  A 607 (-3.9A)
4QJ  A 603 (-3.0A)
4QJ  A 603 (-4.2A)
4QJ  A 603 (-3.5A)
0.65A28.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UHO_A_VDNA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		5b25 CALCIUM/CALMODULIN-D
EPENDENT
3',5'-CYCLIC
NUCLEOTIDE
PHOSPHODIESTERASE 1B
(Homo
sapiens)		5 / 10TYR A 222
LEU A 409
GLN A 421
GLY A 423
PHE A 424
None
GOL  A 607 (-4.6A)
4QJ  A 603 (-3.0A)
4QJ  A 603 (-4.2A)
4QJ  A 603 (-3.5A)
0.91A28.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UHO_A_VDNA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		5cek TRIBBLES HOMOLOG 1
(Homo
sapiens)		5 / 10HIS A 104
ALA A 156
PHE A 122
GLY A 145
PHE A 160
None
1.22A20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UHO_A_VDNA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		5ohj CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens)		6 / 10TYR A 405
HIS A 406
PHE A 586
GLN A 615
GLY A 617
PHE A 618
None
None
9VE  A 801 (-3.6A)
9VE  A 801 (-3.2A)
None
9VE  A 801 (-3.9A)
0.34A12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UHO_A_VDNA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5
(Homo
sapiens)		5 / 10TYR A 793
PHE A 823
MET A 754
GLN A 739
GLY A 742
None
None
9E1  A1001 (-2.8A)
None
None
1.47A12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UHO_A_VDNA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		5viy BG1 FAB HEAVY CHAIN
(Homo
sapiens)		5 / 10TYR H 165
HIS H 220
PHE H 166
LEU H  11
GLY H  94
None
1.44A18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UHO_A_VDNA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		5wh6 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens)		6 / 10TYR A 159
HIS A 160
PHE A 340
GLN A 369
GLY A 371
PHE A 372
AKJ  A 601 ( 4.7A)
None
AKJ  A 601 (-4.5A)
AKJ  A 601 (-3.0A)
None
AKJ  A 601 (-4.1A)
0.33Aundetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOT_A_VDNA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		1soj CGMP-INHIBITED
3',5'-CYCLIC
PHOSPHODIESTERASE B
(Homo
sapiens)		7 / 12TYR A 736
HIS A 737
ILE A 955
SER A 974
GLN A 988
PHE A 991
ILE A 995
IBM  A2111 (-4.5A)
IBM  A2111 ( 4.8A)
IBM  A2111 (-4.2A)
None
IBM  A2111 (-3.3A)
IBM  A2111 (-3.6A)
None
0.67A30.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOT_A_VDNA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens)		5 / 12TYR A 211
HIS A 212
SER A 399
GLN A 413
PHE A 416
IBM  A 503 (-4.6A)
None
None
IBM  A 503 (-3.0A)
IBM  A 503 (-3.4A)
0.87A34.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOT_A_VDNA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		2qyk CYCLIC AMP-SPECIFIC
PHOSPHODIESTERASE
HSPDE4A10
(Homo
sapiens)		12 / 12TYR A 371
HIS A 372
MET A 485
LEU A 531
ILE A 548
MET A 549
SER A 567
MET A 569
SER A 580
GLN A 581
PHE A 584
ILE A 588
NPV  A   3 (-4.4A)
NPV  A   3 (-4.6A)
None
None
NPV  A   3 (-3.8A)
NPV  A   3 ( 4.7A)
None
NPV  A   3 (-3.1A)
NPV  A   3 (-4.5A)
NPV  A   3 (-3.1A)
NPV  A   3 (-3.3A)
None
0.77A87.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOT_A_VDNA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		2qym PHOSPHODIESTERASE 4C
(Homo
sapiens)		7 / 12TYR A 281
HIS A 282
MET A 395
LEU A 441
ILE A 458
PHE A 494
ILE A 498
None
0.67A75.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOT_A_VDNA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		2uyy N-PAC PROTEIN
(Homo
sapiens)		5 / 12MET A 360
ILE A 326
SER A 415
PHE A 417
ILE A 401
None
1.37A22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOT_A_VDNA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		3b2r CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens)		6 / 12TYR A 612
HIS A 613
LEU A 765
GLN A 817
PHE A 820
ILE A 824
VDN  A   1 (-4.8A)
VDN  A   1 (-4.3A)
VDN  A   1 ( 4.7A)
VDN  A   1 (-3.0A)
VDN  A   1 (-3.6A)
None
0.58A28.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOT_A_VDNA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		3bjc CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens)		6 / 12TYR A 612
HIS A 613
LEU A 765
GLN A 817
PHE A 820
ILE A 824
None
MG  A 877 (-4.4A)
WAN  A 901 ( 4.7A)
WAN  A 901 (-3.1A)
WAN  A 901 (-3.7A)
None
0.55A17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOT_A_VDNA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		3bjc CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens)		5 / 12TYR A 612
HIS A 617
GLN A 817
PHE A 820
ILE A 824
None
ZN  A 876 (-3.3A)
WAN  A 901 (-3.1A)
WAN  A 901 (-3.7A)
None
1.33A17.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOT_A_VDNA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A
(Homo
sapiens)		6 / 12TYR A 555
HIS A 556
ILE A 744
GLN A 778
PHE A 781
ILE A 786
None
None
IBM  A   3 (-4.3A)
IBM  A   3 (-3.4A)
IBM  A   3 (-3.5A)
None
1.31A34.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOT_A_VDNA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A
(Homo
sapiens)		7 / 12TYR A 555
HIS A 556
MET A 670
ILE A 744
SER A 777
GLN A 778
PHE A 781
None
None
IBM  A   3 (-4.5A)
IBM  A   3 (-4.3A)
None
IBM  A   3 (-3.4A)
IBM  A   3 (-3.5A)
0.57A34.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOT_A_VDNA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		3fs1 HEPATOCYTE NUCLEAR
FACTOR 4-ALPHA
(Homo
sapiens)		5 / 12LEU A 210
ILE A 196
SER A 309
SER A 139
ILE A 299
None
1.34A21.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOT_A_VDNA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens)		7 / 12TYR A 325
HIS A 326
ILE A 502
MET A 503
MET A 523
SER A 534
GLN A 535
None
D71  A 901 (-4.5A)
D71  A 901 (-4.1A)
D71  A 901 (-3.6A)
D71  A 901 ( 4.0A)
D71  A 901 (-3.4A)
D71  A 901 (-3.1A)
0.89A66.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOT_A_VDNA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens)		8 / 12TYR A 325
HIS A 326
LEU A 485
ILE A 502
MET A 503
SER A 521
GLN A 535
PHE A 538
None
D71  A 901 (-4.5A)
None
D71  A 901 (-4.1A)
D71  A 901 (-3.6A)
None
D71  A 901 (-3.1A)
D71  A 901 (-3.9A)
0.72A66.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOT_A_VDNA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens)		9 / 12TYR A 325
HIS A 326
LEU A 485
ILE A 502
MET A 503
SER A 534
GLN A 535
PHE A 538
ILE A 542
None
D71  A 901 (-4.5A)
None
D71  A 901 (-4.1A)
D71  A 901 (-3.6A)
D71  A 901 (-3.4A)
D71  A 901 (-3.1A)
D71  A 901 (-3.9A)
None
0.55A66.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOT_A_VDNA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens)		8 / 12TYR A 325
MET A 439
LEU A 485
ILE A 502
MET A 503
SER A 521
GLN A 535
PHE A 538
None
D71  A 901 ( 4.0A)
None
D71  A 901 (-4.1A)
D71  A 901 (-3.6A)
None
D71  A 901 (-3.1A)
D71  A 901 (-3.9A)
0.84A66.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOT_A_VDNA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens)		8 / 12TYR A 325
MET A 439
LEU A 485
ILE A 502
MET A 503
SER A 534
GLN A 535
PHE A 538
None
D71  A 901 ( 4.0A)
None
D71  A 901 (-4.1A)
D71  A 901 (-3.6A)
D71  A 901 (-3.4A)
D71  A 901 (-3.1A)
D71  A 901 (-3.9A)
0.78A66.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOT_A_VDNA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens)		7 / 12TYR A 655
HIS A 656
LEU A 809
ILE A 826
GLN A 859
PHE A 862
ILE A 866
None
0.71A19.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOT_A_VDNA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		3o57 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens)		12 / 12TYR A 233
HIS A 234
MET A 347
LEU A 393
ILE A 410
MET A 411
SER A 429
MET A 431
SER A 442
GLN A 443
PHE A 446
ILE A 450
None
None
ZG2  A 506 (-3.9A)
None
ZG2  A 506 (-4.4A)
None
ARS  A   3 (-4.4A)
ZG2  A 506 (-3.4A)
None
ZG2  A 506 (-3.3A)
ZG2  A 506 (-3.6A)
None
0.66A93.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOT_A_VDNA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens)		12 / 12TYR A 159
HIS A 160
MET A 273
LEU A 319
ILE A 336
MET A 337
SER A 355
MET A 357
SER A 368
GLN A 369
PHE A 372
ILE A 376
TYR  A 159 (-1.3A)
HIS  A 160 ( 1.0A)
MET  A 273 (-0.0A)
LEU  A 319 ( 0.6A)
ILE  A 336 ( 0.4A)
MET  A 337 ( 0.0A)
SER  A 355 ( 0.0A)
MET  A 357 (-0.0A)
SER  A 368 (-0.0A)
GLN  A 369 (-0.6A)
PHE  A 372 (-1.3A)
ILE  A 376 (-0.6A)
0.74A84.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOT_A_VDNA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		3ui7 CAMP AND
CAMP-INHIBITED CGMP
3',5'-CYCLIC
PHOSPHODIESTERASE
10A
(Homo
sapiens)		6 / 12TYR A 524
HIS A 525
LEU A 675
ILE A 692
GLN A 726
PHE A 729
C1L  A   1 ( 4.8A)
C1L  A   1 (-4.1A)
C1L  A   1 (-4.3A)
C1L  A   1 (-4.3A)
C1L  A   1 (-2.9A)
C1L  A   1 (-3.5A)
0.65A27.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOT_A_VDNA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		3ui7 CAMP AND
CAMP-INHIBITED CGMP
3',5'-CYCLIC
PHOSPHODIESTERASE
10A
(Homo
sapiens)		6 / 12TYR A 524
LEU A 675
ILE A 692
MET A 713
GLN A 726
PHE A 729
C1L  A   1 ( 4.8A)
C1L  A   1 (-4.3A)
C1L  A   1 (-4.3A)
C1L  A   1 (-3.7A)
C1L  A   1 (-2.9A)
C1L  A   1 (-3.5A)
1.13A27.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOT_A_VDNA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		4cxj KELCH-LIKE
ECH-ASSOCIATED
PROTEIN 1
(Homo
sapiens)		5 / 12TYR A 141
MET A 133
LEU A  81
SER A 166
PHE A 107
None
1.34A17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOT_A_VDNA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens)		7 / 12TYR A 655
HIS A 656
LEU A 809
ILE A 826
GLN A 859
PHE A 862
ILE A 866
None
0.50A27.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOT_A_VDNA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens)		7 / 12TYR A 655
LEU A 809
ILE A 826
MET A 847
GLN A 859
PHE A 862
ILE A 866
None
0.82A27.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOT_A_VDNA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		4jkg PRE-MRNA-PROCESSING-
SPLICING FACTOR 8
(Homo
sapiens)		5 / 12LEU B1889
ILE B1777
SER B1929
PHE B1933
ILE B1937
None
1.31A21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOT_A_VDNA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		4md8 CASEIN KINASE II
SUBUNIT ALPHA
(Homo
sapiens)		5 / 12HIS E 154
LEU E  85
ILE E 174
MET E 163
PHE E 113
None
1.39A21.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOT_A_VDNA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens)		7 / 12TYR A 405
HIS A 406
ILE A 582
MET A 583
SER A 601
MET A 603
GLN A 615
None
MG  A 804 ( 4.9A)
None
None
None
None
None
0.96A61.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOT_A_VDNA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens)		10 / 12TYR A 405
HIS A 406
LEU A 565
ILE A 582
MET A 583
SER A 601
SER A 614
GLN A 615
PHE A 618
ILE A 622
None
MG  A 804 ( 4.9A)
None
None
None
None
None
None
None
None
0.93A61.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOT_A_VDNA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens)		10 / 12TYR A 405
HIS A 406
MET A 519
LEU A 565
ILE A 582
MET A 583
SER A 601
SER A 614
GLN A 615
PHE A 618
None
MG  A 804 ( 4.9A)
None
None
None
None
None
None
None
None
0.95A61.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOT_A_VDNA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		5b25 CALCIUM/CALMODULIN-D
EPENDENT
3',5'-CYCLIC
NUCLEOTIDE
PHOSPHODIESTERASE 1B
(Homo
sapiens)		7 / 12TYR A 222
HIS A 223
MET A 336
SER A 407
GLN A 421
PHE A 424
ILE A 428
None
4QJ  A 603 ( 4.9A)
4QJ  A 603 ( 3.9A)
GOL  A 607 (-4.1A)
4QJ  A 603 (-3.0A)
4QJ  A 603 (-3.5A)
None
0.92A35.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOT_A_VDNA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		5b25 CALCIUM/CALMODULIN-D
EPENDENT
3',5'-CYCLIC
NUCLEOTIDE
PHOSPHODIESTERASE 1B
(Homo
sapiens)		7 / 12TYR A 222
HIS A 223
MET A 336
SER A 407
SER A 420
PHE A 424
ILE A 428
None
4QJ  A 603 ( 4.9A)
4QJ  A 603 ( 3.9A)
GOL  A 607 (-4.1A)
4QJ  A 603 (-4.7A)
4QJ  A 603 (-3.5A)
None
1.08A35.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOT_A_VDNA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		5ohj CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens)		12 / 12TYR A 405
HIS A 406
MET A 519
LEU A 565
ILE A 582
MET A 583
SER A 601
MET A 603
SER A 614
GLN A 615
PHE A 618
ILE A 622
None
None
9VE  A 801 (-3.8A)
9VE  A 801 (-4.7A)
9VE  A 801 (-4.1A)
9VE  A 801 ( 4.0A)
None
9VE  A 801 (-3.6A)
9VE  A 801 (-4.7A)
9VE  A 801 (-3.2A)
9VE  A 801 (-3.9A)
9VE  A 801 (-4.8A)
0.92A11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOT_A_VDNA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		5wh6 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens)		5 / 12HIS A 204
MET A 273
SER A 355
MET A 357
ILE A 376
None
AKJ  A 601 ( 3.9A)
None
AKJ  A 601 (-3.4A)
None
1.08Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOT_A_VDNA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		5wh6 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens)		11 / 12TYR A 159
HIS A 160
MET A 273
LEU A 319
ILE A 336
MET A 337
SER A 355
MET A 357
GLN A 369
PHE A 372
ILE A 376
AKJ  A 601 ( 4.7A)
None
AKJ  A 601 ( 3.9A)
AKJ  A 601 ( 4.6A)
AKJ  A 601 (-3.8A)
AKJ  A 601 ( 3.7A)
None
AKJ  A 601 (-3.4A)
AKJ  A 601 (-3.0A)
AKJ  A 601 (-4.1A)
None
0.68Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOT_A_VDNA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		5wh6 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens)		11 / 12TYR A 159
HIS A 160
MET A 273
LEU A 319
ILE A 336
MET A 337
SER A 355
SER A 368
GLN A 369
PHE A 372
ILE A 376
AKJ  A 601 ( 4.7A)
None
AKJ  A 601 ( 3.9A)
AKJ  A 601 ( 4.6A)
AKJ  A 601 (-3.8A)
AKJ  A 601 ( 3.7A)
None
AKJ  A 601 (-2.5A)
AKJ  A 601 (-3.0A)
AKJ  A 601 (-4.1A)
None
0.74Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOT_B_VDNB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		1jv1 GLCNAC1P
URIDYLTRANSFERASE
ISOFORM 1: AGX1
(Homo
sapiens)		5 / 12LEU A 106
SER A 173
MET A 171
GLN A 233
PHE A 194
None
1.44A21.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOT_B_VDNB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		1soj CGMP-INHIBITED
3',5'-CYCLIC
PHOSPHODIESTERASE B
(Homo
sapiens)		6 / 12TYR A 736
HIS A 737
ILE A 955
SER A 974
GLN A 988
PHE A 991
IBM  A2111 (-4.5A)
IBM  A2111 ( 4.8A)
IBM  A2111 (-4.2A)
None
IBM  A2111 (-3.3A)
IBM  A2111 (-3.6A)
0.51A30.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOT_B_VDNB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens)		6 / 12TYR A 211
HIS A 212
ASN A 365
SER A 399
GLN A 413
PHE A 416
IBM  A 503 (-4.6A)
None
IBM  A 503 ( 4.7A)
None
IBM  A 503 (-3.0A)
IBM  A 503 (-3.4A)
0.67A34.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOT_B_VDNB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		2ija ARYLAMINE
N-ACETYLTRANSFERASE
1
(Homo
sapiens)		5 / 12TYR A 190
LEU A 135
ILE A 189
SER A 184
SER A 128
None
1.45A19.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOT_B_VDNB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		2qyk CYCLIC AMP-SPECIFIC
PHOSPHODIESTERASE
HSPDE4A10
(Homo
sapiens)		11 / 12TYR A 371
HIS A 372
MET A 485
LEU A 531
ASN A 533
ILE A 548
MET A 549
SER A 567
MET A 569
GLN A 581
PHE A 584
NPV  A   3 (-4.4A)
NPV  A   3 (-4.6A)
None
None
NPV  A   3 (-4.4A)
NPV  A   3 (-3.8A)
NPV  A   3 ( 4.7A)
None
NPV  A   3 (-3.1A)
NPV  A   3 (-3.1A)
NPV  A   3 (-3.3A)
0.63A87.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOT_B_VDNB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		2qyk CYCLIC AMP-SPECIFIC
PHOSPHODIESTERASE
HSPDE4A10
(Homo
sapiens)		11 / 12TYR A 371
HIS A 372
MET A 485
LEU A 531
ASN A 533
ILE A 548
MET A 549
SER A 567
MET A 569
SER A 580
PHE A 584
NPV  A   3 (-4.4A)
NPV  A   3 (-4.6A)
None
None
NPV  A   3 (-4.4A)
NPV  A   3 (-3.8A)
NPV  A   3 ( 4.7A)
None
NPV  A   3 (-3.1A)
NPV  A   3 (-4.5A)
NPV  A   3 (-3.3A)
0.69A87.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOT_B_VDNB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		2qym PHOSPHODIESTERASE 4C
(Homo
sapiens)		7 / 12TYR A 281
HIS A 282
MET A 395
LEU A 441
ASN A 443
ILE A 458
PHE A 494
None
0.58A75.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOT_B_VDNB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		2z80 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens)		5 / 12LEU A 131
ILE A  91
SER A  98
SER A 118
PHE A 120
None
1.37A22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOT_B_VDNB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		3b2r CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens)		5 / 12TYR A 612
HIS A 613
LEU A 765
GLN A 817
PHE A 820
VDN  A   1 (-4.8A)
VDN  A   1 (-4.3A)
VDN  A   1 ( 4.7A)
VDN  A   1 (-3.0A)
VDN  A   1 (-3.6A)
0.59A28.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOT_B_VDNB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		3bjc CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens)		5 / 12TYR A 612
HIS A 613
LEU A 765
GLN A 817
PHE A 820
None
MG  A 877 (-4.4A)
WAN  A 901 ( 4.7A)
WAN  A 901 (-3.1A)
WAN  A 901 (-3.7A)
0.53A17.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOT_B_VDNB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A
(Homo
sapiens)		6 / 12TYR A 555
HIS A 556
ASN A 729
ILE A 744
SER A 777
PHE A 781
None
None
None
IBM  A   3 (-4.3A)
None
IBM  A   3 (-3.5A)
0.60A34.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOT_B_VDNB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A
(Homo
sapiens)		7 / 12TYR A 555
HIS A 556
MET A 670
ASN A 729
ILE A 744
GLN A 778
PHE A 781
None
None
IBM  A   3 (-4.5A)
None
IBM  A   3 (-4.3A)
IBM  A   3 (-3.4A)
IBM  A   3 (-3.5A)
0.40A34.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOT_B_VDNB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens)		5 / 12HIS A 330
MET A 439
LEU A 485
GLN A 535
PHE A 538
 ZN  A 801 (-3.4A)
D71  A 901 ( 4.0A)
None
D71  A 901 (-3.1A)
D71  A 901 (-3.9A)
1.15A66.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOT_B_VDNB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens)		9 / 12MET A 439
LEU A 485
ASN A 487
ILE A 502
MET A 503
SER A 521
SER A 534
GLN A 535
PHE A 538
D71  A 901 ( 4.0A)
None
D71  A 901 (-4.5A)
D71  A 901 (-4.1A)
D71  A 901 (-3.6A)
None
D71  A 901 (-3.4A)
D71  A 901 (-3.1A)
D71  A 901 (-3.9A)
0.81A66.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOT_B_VDNB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens)		10 / 12TYR A 325
HIS A 326
LEU A 485
ASN A 487
ILE A 502
MET A 503
SER A 521
SER A 534
GLN A 535
PHE A 538
None
D71  A 901 (-4.5A)
None
D71  A 901 (-4.5A)
D71  A 901 (-4.1A)
D71  A 901 (-3.6A)
None
D71  A 901 (-3.4A)
D71  A 901 (-3.1A)
D71  A 901 (-3.9A)
0.68A66.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOT_B_VDNB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens)		7 / 12TYR A 325
ILE A 502
MET A 503
SER A 521
MET A 523
SER A 534
GLN A 535
None
D71  A 901 (-4.1A)
D71  A 901 (-3.6A)
None
D71  A 901 ( 4.0A)
D71  A 901 (-3.4A)
D71  A 901 (-3.1A)
1.15A66.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOT_B_VDNB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens)		6 / 12TYR A 655
HIS A 656
LEU A 809
ILE A 826
GLN A 859
PHE A 862
None
0.85A19.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOT_B_VDNB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		3n3z HIGH AFFINITY
CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 9A
(Homo
sapiens)		5 / 12HIS A 252
MET A 365
ASN A 405
GLN A 453
PHE A 456
None
None
IBM  A   1 (-3.5A)
IBM  A   1 (-3.5A)
IBM  A   1 (-3.4A)
0.80A30.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOT_B_VDNB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		3o57 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens)		10 / 12TYR A 233
HIS A 234
ASN A 395
ILE A 410
MET A 411
SER A 429
MET A 431
SER A 442
GLN A 443
PHE A 446
None
None
ZG2  A 506 (-4.3A)
ZG2  A 506 (-4.4A)
None
ARS  A   3 (-4.4A)
ZG2  A 506 (-3.4A)
None
ZG2  A 506 (-3.3A)
ZG2  A 506 (-3.6A)
0.75A93.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOT_B_VDNB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		3o57 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens)		11 / 12TYR A 233
HIS A 234
MET A 347
LEU A 393
ASN A 395
ILE A 410
MET A 411
SER A 429
SER A 442
GLN A 443
PHE A 446
None
None
ZG2  A 506 (-3.9A)
None
ZG2  A 506 (-4.3A)
ZG2  A 506 (-4.4A)
None
ARS  A   3 (-4.4A)
None
ZG2  A 506 (-3.3A)
ZG2  A 506 (-3.6A)
0.56A93.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOT_B_VDNB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens)		11 / 12TYR A 159
HIS A 160
MET A 273
LEU A 319
ASN A 321
ILE A 336
MET A 337
SER A 355
MET A 357
GLN A 369
PHE A 372
TYR  A 159 (-1.3A)
HIS  A 160 ( 1.0A)
MET  A 273 (-0.0A)
LEU  A 319 ( 0.6A)
ASN  A 321 (-0.6A)
ILE  A 336 ( 0.4A)
MET  A 337 ( 0.0A)
SER  A 355 ( 0.0A)
MET  A 357 (-0.0A)
GLN  A 369 (-0.6A)
PHE  A 372 (-1.3A)
0.59A84.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOT_B_VDNB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens)		11 / 12TYR A 159
HIS A 160
MET A 273
LEU A 319
ASN A 321
ILE A 336
MET A 337
SER A 355
MET A 357
SER A 368
PHE A 372
TYR  A 159 (-1.3A)
HIS  A 160 ( 1.0A)
MET  A 273 (-0.0A)
LEU  A 319 ( 0.6A)
ASN  A 321 (-0.6A)
ILE  A 336 ( 0.4A)
MET  A 337 ( 0.0A)
SER  A 355 ( 0.0A)
MET  A 357 (-0.0A)
SER  A 368 (-0.0A)
PHE  A 372 (-1.3A)
0.73A84.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOT_B_VDNB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		3ui7 CAMP AND
CAMP-INHIBITED CGMP
3',5'-CYCLIC
PHOSPHODIESTERASE
10A
(Homo
sapiens)		7 / 12TYR A 524
HIS A 525
LEU A 675
ILE A 692
MET A 713
GLN A 726
PHE A 729
C1L  A   1 ( 4.8A)
C1L  A   1 (-4.1A)
C1L  A   1 (-4.3A)
C1L  A   1 (-4.3A)
C1L  A   1 (-3.7A)
C1L  A   1 (-2.9A)
C1L  A   1 (-3.5A)
1.04A27.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOT_B_VDNB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens)		7 / 12TYR A 655
HIS A 656
LEU A 809
ILE A 826
MET A 847
GLN A 859
PHE A 862
None
0.76A27.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOT_B_VDNB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		4md8 CASEIN KINASE II
SUBUNIT ALPHA
(Homo
sapiens)		5 / 12HIS E 154
LEU E  85
ILE E 174
MET E 163
PHE E 113
None
1.40A21.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOT_B_VDNB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens)		7 / 12TYR A 405
ASN A 567
ILE A 582
MET A 583
SER A 601
MET A 603
GLN A 615
None
1.09A61.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOT_B_VDNB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens)		10 / 12TYR A 405
HIS A 406
LEU A 565
ASN A 567
ILE A 582
MET A 583
SER A 601
SER A 614
GLN A 615
PHE A 618
None
MG  A 804 ( 4.9A)
None
None
None
None
None
None
None
None
0.83A61.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOT_B_VDNB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens)		10 / 12TYR A 405
MET A 519
LEU A 565
ASN A 567
ILE A 582
MET A 583
SER A 601
SER A 614
GLN A 615
PHE A 618
None
0.87A61.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOT_B_VDNB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		5b25 CALCIUM/CALMODULIN-D
EPENDENT
3',5'-CYCLIC
NUCLEOTIDE
PHOSPHODIESTERASE 1B
(Homo
sapiens)		6 / 12TYR A 222
HIS A 223
MET A 336
SER A 407
GLN A 421
PHE A 424
None
4QJ  A 603 ( 4.9A)
4QJ  A 603 ( 3.9A)
GOL  A 607 (-4.1A)
4QJ  A 603 (-3.0A)
4QJ  A 603 (-3.5A)
0.81A35.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOT_B_VDNB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		5ohj CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens)		8 / 12HIS A 406
MET A 519
LEU A 565
MET A 583
SER A 601
MET A 603
SER A 614
PHE A 618
None
9VE  A 801 (-3.8A)
9VE  A 801 (-4.7A)
9VE  A 801 ( 4.0A)
None
9VE  A 801 (-3.6A)
9VE  A 801 (-4.7A)
9VE  A 801 (-3.9A)
0.91A11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOT_B_VDNB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		5ohj CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens)		11 / 12TYR A 405
HIS A 406
MET A 519
LEU A 565
ASN A 567
ILE A 582
MET A 583
SER A 601
MET A 603
GLN A 615
PHE A 618
None
None
9VE  A 801 (-3.8A)
9VE  A 801 (-4.7A)
9VE  A 801 (-4.1A)
9VE  A 801 (-4.1A)
9VE  A 801 ( 4.0A)
None
9VE  A 801 (-3.6A)
9VE  A 801 (-3.2A)
9VE  A 801 (-3.9A)
0.64A11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOT_B_VDNB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		5wh6 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens)		11 / 12TYR A 159
HIS A 160
MET A 273
LEU A 319
ASN A 321
ILE A 336
MET A 337
SER A 355
MET A 357
GLN A 369
PHE A 372
AKJ  A 601 ( 4.7A)
None
AKJ  A 601 ( 3.9A)
AKJ  A 601 ( 4.6A)
AKJ  A 601 (-4.3A)
AKJ  A 601 (-3.8A)
AKJ  A 601 ( 3.7A)
None
AKJ  A 601 (-3.4A)
AKJ  A 601 (-3.0A)
AKJ  A 601 (-4.1A)
0.58Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOT_B_VDNB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		5wh6 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens)		11 / 12TYR A 159
HIS A 160
MET A 273
LEU A 319
ASN A 321
ILE A 336
MET A 337
SER A 355
SER A 368
GLN A 369
PHE A 372
AKJ  A 601 ( 4.7A)
None
AKJ  A 601 ( 3.9A)
AKJ  A 601 ( 4.6A)
AKJ  A 601 (-4.3A)
AKJ  A 601 (-3.8A)
AKJ  A 601 ( 3.7A)
None
AKJ  A 601 (-2.5A)
AKJ  A 601 (-3.0A)
AKJ  A 601 (-4.1A)
0.62Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XP0_A_VDNA201_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens)		5 / 10TYR A 211
VAL A 380
LEU A 401
GLN A 413
PHE A 416
IBM  A 503 (-4.6A)
IBM  A 503 (-4.7A)
None
IBM  A 503 (-3.0A)
IBM  A 503 (-3.4A)
0.85A29.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XP0_A_VDNA201_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		3b2r CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens)		9 / 10TYR A 612
LEU A 765
ALA A 767
ILE A 768
VAL A 782
ALA A 783
MET A 816
GLN A 817
PHE A 820
VDN  A   1 (-4.8A)
VDN  A   1 ( 4.7A)
VDN  A   1 ( 3.8A)
VDN  A   1 (-4.5A)
VDN  A   1 ( 4.7A)
VDN  A   1 ( 4.0A)
VDN  A   1 (-4.0A)
VDN  A   1 (-3.0A)
VDN  A   1 (-3.6A)
0.28A94.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XP0_A_VDNA201_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		3bjc CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens)		9 / 10TYR A 612
LEU A 765
ALA A 767
ILE A 768
VAL A 782
ALA A 783
MET A 816
GLN A 817
PHE A 820
None
WAN  A 901 ( 4.7A)
WAN  A 901 ( 3.9A)
WAN  A 901 ( 4.9A)
WAN  A 901 ( 4.9A)
WAN  A 901 (-3.6A)
WAN  A 901 (-4.3A)
WAN  A 901 (-3.1A)
WAN  A 901 (-3.7A)
0.35A46.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XP0_A_VDNA201_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		3ll8 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
ALPHA ISOFORM
(Homo
sapiens)		5 / 10LEU A 139
ALA A 135
ILE A 138
VAL A  34
ALA A  31
None
1.16A22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XP0_A_VDNA201_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		4hxx METHIONINE
AMINOPEPTIDASE 1
(Homo
sapiens)		5 / 10LEU A 181
ALA A 185
ILE A 184
VAL A 158
ALA A 155
None
1.10A21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XP0_A_VDNA201_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		4iu6 METHIONINE
AMINOPEPTIDASE 1
(Homo
sapiens)		5 / 10LEU A 181
ALA A 185
ILE A 184
VAL A 158
ALA A 155
None
1.12A21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XP0_A_VDNA201_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		4yu9 GLUTAMINYL-PEPTIDE
CYCLOTRANSFERASE
(Homo
sapiens)		5 / 10LEU A 271
ALA A 273
ILE A 274
ALA A  46
LEU A 359
None
0.95A22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XP0_A_VDNA201_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		5aga DNA POLYMERASE THETA
(Homo
sapiens)		5 / 10TYR A 239
ALA A 544
ILE A 539
ALA A 554
LEU A 519
None
1.12A17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XP0_A_VDNA201_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		5k13 RETINOIC ACID
RECEPTOR ALPHA
(Homo
sapiens)		5 / 10LEU A 356
ALA A 358
LEU A 319
MET A 373
PHE A 374
None
1.19A21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XP0_A_VDNA201_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		5m32 PROTEASOME SUBUNIT
BETA TYPE-2
(Homo
sapiens)		5 / 10LEU J 160
ALA J 156
ILE J   7
VAL J 182
LEU J  43
None
1.14A19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XP0_A_VDNA201_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		6ek6 LYSINE-SPECIFIC
DEMETHYLASE
5B,LYSINE-SPECIFIC
DEMETHYLASE 5B
(Homo
sapiens)		5 / 10LEU A 472
ALA A 473
ILE A 475
VAL A 647
ALA A 648
None
1.15A11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_A_VDNA1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		1by7 PROTEIN (PLASMINOGEN
ACTIVATOR
INHIBITOR-2)
(Homo
sapiens)		5 / 12LEU A 314
ALA A 358
PHE A  16
ILE A 406
PHE A 396
None
1.05A21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_A_VDNA1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		1d5f E6AP HECT CATALYTIC
DOMAIN, E3 LIGASE
(Homo
sapiens)		5 / 12ILE A 770
LEU A 840
ALA A 842
ILE A 843
ILE A 804
None
1.03A21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_A_VDNA1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		1soj CGMP-INHIBITED
3',5'-CYCLIC
PHOSPHODIESTERASE B
(Homo
sapiens)		5 / 12TYR A 736
HIS A 737
PHE A 959
GLN A 988
PHE A 991
IBM  A2111 (-4.5A)
IBM  A2111 ( 4.8A)
None
IBM  A2111 (-3.3A)
IBM  A2111 (-3.6A)
0.50A24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_A_VDNA1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		1v5w MEIOTIC
RECOMBINATION
PROTEIN DMC1/LIM15
HOMOLOG
(Homo
sapiens)		5 / 12ILE A 335
ALA A 124
ILE A 301
ILE A 101
PHE A 108
None
1.06A22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_A_VDNA1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens)		7 / 12TYR A 211
HIS A 212
VAL A 380
PHE A 384
ILE A 409
GLN A 413
PHE A 416
IBM  A 503 (-4.6A)
None
IBM  A 503 (-4.7A)
IBM  A 503 (-4.5A)
None
IBM  A 503 (-3.0A)
IBM  A 503 (-3.4A)
0.86A28.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_A_VDNA1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		2dw4 LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1
(Homo
sapiens)		5 / 12LEU A 643
ILE A 780
VAL A 621
ILE A 825
PHE A 798
None
1.11A19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_A_VDNA1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		2nz4 U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN A
(Homo
sapiens)		5 / 12ILE A  21
LEU A  30
ALA A  32
ILE A  33
PHE A  77
None
0.97A14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_A_VDNA1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		2qyk CYCLIC AMP-SPECIFIC
PHOSPHODIESTERASE
HSPDE4A10
(Homo
sapiens)		6 / 12TYR A 371
HIS A 372
LEU A 531
PHE A 552
GLN A 581
PHE A 584
NPV  A   3 (-4.4A)
NPV  A   3 (-4.6A)
None
NPV  A   3 (-4.8A)
NPV  A   3 (-3.1A)
NPV  A   3 (-3.3A)
0.61A29.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B2R_A_VDNA1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		3bjc CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens)		11 / 12TYR A 612
HIS A 613
LEU A 765
ALA A 767
ILE A 768
VAL A 782
PHE A 786
ILE A 813
MET A 816
GLN A 817
PHE A 820
None
MG  A 877 (-4.4A)
WAN  A 901 ( 4.7A)
WAN  A 901 ( 3.9A)
WAN  A 901 ( 4.9A)
WAN  A 901 ( 4.9A)
WAN  A 901 (-4.8A)
WAN  A 901 ( 4.3A)
WAN  A 901 (-4.3A)
WAN  A 901 (-3.1A)
WAN  A 901 (-3.7A)
0.58A38.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B2R_A_VDNA1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		3bjc CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens)		6 / 12TYR A 612
HIS A 617
LEU A 765
ILE A 768
GLN A 817
PHE A 820
None
ZN  A 876 (-3.3A)
WAN  A 901 ( 4.7A)
WAN  A 901 ( 4.9A)
WAN  A 901 (-3.1A)
WAN  A 901 (-3.7A)
1.40A38.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_A_VDNA1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A
(Homo
sapiens)		5 / 12TYR A 555
HIS A 556
ILE A 774
GLN A 778
PHE A 781
None
None
None
IBM  A   3 (-3.4A)
IBM  A   3 (-3.5A)
0.58A25.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_A_VDNA1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens)		6 / 12TYR A 325
HIS A 326
LEU A 485
PHE A 506
GLN A 535
PHE A 538
None
D71  A 901 (-4.5A)
None
D71  A 901 (-4.8A)
D71  A 901 (-3.1A)
D71  A 901 (-3.9A)
0.71A26.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_A_VDNA1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens)		6 / 12TYR A 655
HIS A 656
LEU A 809
ILE A 855
GLN A 859
PHE A 862
None
0.85A21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_A_VDNA1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		3max HISTONE DEACETYLASE
2
(Homo
sapiens)		5 / 12HIS A  73
LEU A 166
ALA A 164
ILE A 165
PHE A 192
None
1.09A20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_A_VDNA1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		3o57 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens)		6 / 12TYR A 233
HIS A 234
LEU A 393
PHE A 414
GLN A 443
PHE A 446
None
None
None
ZG2  A 506 (-4.4A)
ZG2  A 506 (-3.3A)
ZG2  A 506 (-3.6A)
0.62A28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_A_VDNA1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		3pt3 E3 UBIQUITIN-PROTEIN
LIGASE UBR5
(Homo
sapiens)		5 / 12ILE A2717
LEU A2788
ALA A2790
ILE A2791
ILE A2752
None
1.11A16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_A_VDNA1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens)		6 / 12TYR A 159
HIS A 160
LEU A 319
PHE A 340
GLN A 369
PHE A 372
TYR  A 159 (-1.3A)
HIS  A 160 ( 1.0A)
LEU  A 319 ( 0.6A)
PHE  A 340 (-1.3A)
GLN  A 369 (-0.6A)
PHE  A 372 (-1.3A)
0.55A29.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B2R_A_VDNA1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		3ui7 CAMP AND
CAMP-INHIBITED CGMP
3',5'-CYCLIC
PHOSPHODIESTERASE
10A
(Homo
sapiens)		6 / 12TYR A 524
HIS A 525
LEU A 675
PHE A 696
GLN A 726
PHE A 729
C1L  A   1 ( 4.8A)
C1L  A   1 (-4.1A)
C1L  A   1 (-4.3A)
C1L  A   1 ( 4.7A)
C1L  A   1 (-2.9A)
C1L  A   1 (-3.5A)
0.69A40.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_A_VDNA1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		4bkx HISTONE DEACETYLASE
1
(Homo
sapiens)		5 / 12HIS B  68
LEU B 161
ALA B 159
ILE B 160
PHE B 187
None
1.06A20.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B2R_A_VDNA1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens)		7 / 12TYR A 655
HIS A 656
LEU A 809
PHE A 830
ILE A 855
GLN A 859
PHE A 862
None
0.61A35.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_A_VDNA1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		4pkd U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN
A,U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN 70
KDA
(Homo
sapiens;
Sus
scrofa)		5 / 12ILE B  21
LEU B  30
ALA B  32
ILE B  33
PHE B  77
None
0.89A18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_A_VDNA1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens)		6 / 12TYR A 405
HIS A 406
LEU A 565
PHE A 586
GLN A 615
PHE A 618
None
MG  A 804 ( 4.9A)
None
None
None
None
0.70A22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_A_VDNA1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		5b25 CALCIUM/CALMODULIN-D
EPENDENT
3',5'-CYCLIC
NUCLEOTIDE
PHOSPHODIESTERASE 1B
(Homo
sapiens)		5 / 12TYR A 222
HIS A 223
PHE A 392
GLN A 421
PHE A 424
None
4QJ  A 603 ( 4.9A)
GOL  A 607 (-3.9A)
4QJ  A 603 (-3.0A)
4QJ  A 603 (-3.5A)
0.57A28.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_A_VDNA1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		5hdt SISTER CHROMATID
COHESION PROTEIN
PDS5 HOMOLOG B
(Homo
sapiens)		5 / 12TYR A 478
ILE A 622
LEU A 650
ALA A 648
ILE A 613
None
1.06A14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_A_VDNA1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		5l3d LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1A
(Homo
sapiens)		5 / 12LEU A 643
ILE A 780
VAL A 621
ILE A 825
PHE A 798
None
1.12A17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_A_VDNA1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		5ohj CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens)		6 / 12TYR A 405
HIS A 406
LEU A 565
PHE A 586
GLN A 615
PHE A 618
None
None
9VE  A 801 (-4.7A)
9VE  A 801 (-3.6A)
9VE  A 801 (-3.2A)
9VE  A 801 (-3.9A)
0.68A13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_A_VDNA1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		5wc2 PACHYTENE CHECKPOINT
PROTEIN 2 HOMOLOG
(Homo
sapiens)		5 / 12ILE A 284
ALA A 122
VAL A 249
ILE A 240
PHE A 233
None
1.09A13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_A_VDNA1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		5wh6 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens)		6 / 12TYR A 159
HIS A 160
LEU A 319
PHE A 340
GLN A 369
PHE A 372
AKJ  A 601 ( 4.7A)
None
AKJ  A 601 ( 4.6A)
AKJ  A 601 (-4.5A)
AKJ  A 601 (-3.0A)
AKJ  A 601 (-4.1A)
0.68Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_B_VDNB1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		1d5f E6AP HECT CATALYTIC
DOMAIN, E3 LIGASE
(Homo
sapiens)		5 / 11ILE A 770
LEU A 840
ALA A 842
ILE A 843
ILE A 804
None
1.07A21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_B_VDNB1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		1d5f E6AP HECT CATALYTIC
DOMAIN, E3 LIGASE
(Homo
sapiens)		5 / 11ILE A 770
LEU A 840
ALA A 842
ILE A 843
PHE A 774
None
1.14A21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_B_VDNB1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		1nug PROTEIN-GLUTAMINE
GLUTAMYLTRANSFERASE
E
(Homo
sapiens)		5 / 11ILE A 660
LEU A 686
ALA A 684
VAL A 631
ILE A 643
None
1.15A19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_B_VDNB1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens)		6 / 11TYR A 211
HIS A 212
VAL A 380
ILE A 409
GLN A 413
PHE A 416
IBM  A 503 (-4.6A)
None
IBM  A 503 (-4.7A)
None
IBM  A 503 (-3.0A)
IBM  A 503 (-3.4A)
0.78A28.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_B_VDNB1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		2dw4 LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1
(Homo
sapiens)		5 / 11LEU A 643
ILE A 780
VAL A 621
ILE A 825
PHE A 798
None
1.10A19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_B_VDNB1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		2nz4 U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN A
(Homo
sapiens)		5 / 11ILE A  21
LEU A  30
ALA A  32
ILE A  33
PHE A  77
None
0.94A14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_B_VDNB1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		2qyk CYCLIC AMP-SPECIFIC
PHOSPHODIESTERASE
HSPDE4A10
(Homo
sapiens)		5 / 11TYR A 371
HIS A 372
LEU A 531
GLN A 581
PHE A 584
NPV  A   3 (-4.4A)
NPV  A   3 (-4.6A)
None
NPV  A   3 (-3.1A)
NPV  A   3 (-3.3A)
0.49A29.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B2R_B_VDNB1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		3bjc CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens)		10 / 11TYR A 612
HIS A 613
LEU A 765
ALA A 767
ILE A 768
VAL A 782
ILE A 813
MET A 816
GLN A 817
PHE A 820
None
MG  A 877 (-4.4A)
WAN  A 901 ( 4.7A)
WAN  A 901 ( 3.9A)
WAN  A 901 ( 4.9A)
WAN  A 901 ( 4.9A)
WAN  A 901 ( 4.3A)
WAN  A 901 (-4.3A)
WAN  A 901 (-3.1A)
WAN  A 901 (-3.7A)
0.41A38.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_B_VDNB1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A
(Homo
sapiens)		5 / 11TYR A 555
HIS A 556
ILE A 774
GLN A 778
PHE A 781
None
None
None
IBM  A   3 (-3.4A)
IBM  A   3 (-3.5A)
0.55A25.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_B_VDNB1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens)		5 / 11TYR A 325
HIS A 326
LEU A 485
GLN A 535
PHE A 538
None
D71  A 901 (-4.5A)
None
D71  A 901 (-3.1A)
D71  A 901 (-3.9A)
0.73A26.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_B_VDNB1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens)		5 / 11TYR A 655
HIS A 656
LEU A 809
GLN A 859
PHE A 862
None
0.68A21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_B_VDNB1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens)		5 / 11TYR A 655
HIS A 656
LEU A 809
ILE A 855
PHE A 862
None
0.60A21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_B_VDNB1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		3l6r SERINE RACEMASE
(Homo
sapiens)		5 / 11ILE A 160
ALA A 167
ILE A 166
VAL A  12
ILE A  19
None
1.11A20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_B_VDNB1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		3max HISTONE DEACETYLASE
2
(Homo
sapiens)		5 / 11HIS A  73
LEU A 166
ALA A 164
ILE A 165
PHE A 192
None
1.14A20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_B_VDNB1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		3o57 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens)		5 / 11TYR A 233
HIS A 234
LEU A 393
GLN A 443
PHE A 446
None
None
None
ZG2  A 506 (-3.3A)
ZG2  A 506 (-3.6A)
0.61A28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_B_VDNB1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		3pt3 E3 UBIQUITIN-PROTEIN
LIGASE UBR5
(Homo
sapiens)		5 / 11ILE A2717
LEU A2788
ALA A2790
ILE A2791
ILE A2752
None
1.14A16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_B_VDNB1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens)		5 / 11TYR A 159
HIS A 160
LEU A 319
GLN A 369
PHE A 372
TYR  A 159 (-1.3A)
HIS  A 160 ( 1.0A)
LEU  A 319 ( 0.6A)
GLN  A 369 (-0.6A)
PHE  A 372 (-1.3A)
0.45A29.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B2R_B_VDNB1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		3ui7 CAMP AND
CAMP-INHIBITED CGMP
3',5'-CYCLIC
PHOSPHODIESTERASE
10A
(Homo
sapiens)		5 / 11TYR A 524
HIS A 525
LEU A 675
GLN A 726
PHE A 729
C1L  A   1 ( 4.8A)
C1L  A   1 (-4.1A)
C1L  A   1 (-4.3A)
C1L  A   1 (-2.9A)
C1L  A   1 (-3.5A)
0.54A40.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_B_VDNB1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		4bkx HISTONE DEACETYLASE
1
(Homo
sapiens)		5 / 11HIS B  68
LEU B 161
ALA B 159
ILE B 160
PHE B 187
None
1.10A20.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B2R_B_VDNB1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens)		6 / 11TYR A 655
HIS A 656
LEU A 809
ILE A 855
GLN A 859
PHE A 862
None
0.61A35.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_B_VDNB1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		4kxz GC1008 HEAVY CHAIN
TRANSFORMING GROWTH
FACTOR BETA-2
(Homo
sapiens)		5 / 11ILE A  88
ALA A  41
ILE A  22
ILE H  54
PHE A  24
None
1.15A15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_B_VDNB1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		4pkd U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN
A,U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN 70
KDA
(Homo
sapiens;
Sus
scrofa)		5 / 11ILE B  21
LEU B  30
ALA B  32
ILE B  33
PHE B  77
None
0.87A18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_B_VDNB1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens)		5 / 11TYR A 405
HIS A 406
LEU A 565
GLN A 615
PHE A 618
None
MG  A 804 ( 4.9A)
None
None
None
0.64A22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_B_VDNB1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		5gu6 ENDOPLASMIC
RETICULUM RESIDENT
PROTEIN 44
(Homo
sapiens)		5 / 11ILE A 249
LEU A 237
ILE A 292
ILE A 311
PHE A 306
None
1.15A24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_B_VDNB1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		5hdt SISTER CHROMATID
COHESION PROTEIN
PDS5 HOMOLOG B
(Homo
sapiens)		5 / 11TYR A 478
ILE A 622
LEU A 650
ALA A 648
ILE A 613
None
1.08A14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_B_VDNB1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		5ohj CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens)		5 / 11TYR A 405
HIS A 406
LEU A 565
GLN A 615
PHE A 618
None
None
9VE  A 801 (-4.7A)
9VE  A 801 (-3.2A)
9VE  A 801 (-3.9A)
0.69A13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_B_VDNB1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		5wc2 PACHYTENE CHECKPOINT
PROTEIN 2 HOMOLOG
(Homo
sapiens)		5 / 11ILE A 284
ALA A 122
VAL A 249
ILE A 240
PHE A 233
None
1.08A13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_B_VDNB1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		5wh6 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens)		5 / 11TYR A 159
HIS A 160
LEU A 319
GLN A 369
PHE A 372
AKJ  A 601 ( 4.7A)
None
AKJ  A 601 ( 4.6A)
AKJ  A 601 (-3.0A)
AKJ  A 601 (-4.1A)
0.66Aundetectable