POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1K4T_D_TTCD990_1 (DNA TOPOISOMERASE I)	1z8l	GLUTAMATE CARBOXYPEPTIDASE II (Homo sapiens)	4 / 5	GLU A 425 ARG A 534 ASP A 465 THR A 538	ZN  A1752 (-2.5A) None None None	0.98A	22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1K4T_D_TTCD990_1 (DNA TOPOISOMERASE I)	2wd9	ACYL-COENZYME A SYNTHETASE ACSM2A, MITOCHONDRIAL (Homo sapiens)	4 / 5	GLU A 477 ARG A 461 ASP A 446 THR A 366	None	1.14A	20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1K4T_D_TTCD990_1 (DNA TOPOISOMERASE I)	3dzu	PEROXISOME PROLIFERATOR-ACTIVAT ED RECEPTOR GAMMA RETINOIC ACID RECEPTOR RXR-ALPHA (Homo sapiens)	4 / 5	GLU A 207 ARG A 202 ASP D 337 THR A 168	None	1.49A	20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1K4T_D_TTCD990_1 (DNA TOPOISOMERASE I)	3fed	GLUTAMATE CARBOXYPEPTIDASE III (Homo sapiens)	4 / 5	GLU A 415 ARG A 524 ASP A 455 THR A 528	ZN  A1751 ( 1.9A) BIX  A   1 ( 3.1A) None None	1.04A	23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1K4T_D_TTCD990_1 (DNA TOPOISOMERASE I)	3hig	AMILORIDE-SENSITIVE AMINE OXIDASE (Homo sapiens)	4 / 5	GLU A 393 ARG A 453 LYS A 478 ASP A 466	None	1.27A	21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1K4T_D_TTCD990_1 (DNA TOPOISOMERASE I)	4hzh	PROTHROMBIN (Homo sapiens)	4 / 5	GLU A 250 ARG A 418 ASP A 417 THR A 186	None	1.31A	20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1K4T_D_TTCD990_1 (DNA TOPOISOMERASE I)	5n7f	MEMBRANE-ASSOCIATED GUANYLATE KINASE, WW AND PDZ DOMAIN-CONTAINING PROTEIN 1,ANNEXIN A2 (Homo sapiens)	4 / 5	GLU A 575 ARG A 554 ASP A 517 THR A 473	None	1.13A	21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1K4T_D_TTCD990_1 (DNA TOPOISOMERASE I)	5vho	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 10 26S PROTEASOME REGULATORY SUBUNIT 6B (Homo sapiens)	4 / 5	GLU G 187 ARG D 338 LYS D 369 ASP D 368	None	1.34A	16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1RR8_A_TTCA100_1 (DNA TOPOISOMERASE I)	1z8l	GLUTAMATE CARBOXYPEPTIDASE II (Homo sapiens)	4 / 5	GLU A 425 ARG A 534 ASP A 465 THR A 538	ZN  A1752 (-2.5A) None None None	1.06A	22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1RR8_A_TTCA100_1 (DNA TOPOISOMERASE I)	2lav	VACCINIA-RELATED KINASE 1 (Homo sapiens)	4 / 5	GLU A  73 LYS A 179 ASP A 177 THR A 224	None	1.46A	21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1RR8_A_TTCA100_1 (DNA TOPOISOMERASE I)	2wd9	ACYL-COENZYME A SYNTHETASE ACSM2A, MITOCHONDRIAL (Homo sapiens)	4 / 5	GLU A 477 ARG A 461 ASP A 446 THR A 366	None	1.25A	21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1RR8_A_TTCA100_1 (DNA TOPOISOMERASE I)	3dzu	PEROXISOME PROLIFERATOR-ACTIVAT ED RECEPTOR GAMMA RETINOIC ACID RECEPTOR RXR-ALPHA (Homo sapiens)	4 / 5	GLU A 207 ARG A 202 ASP D 337 THR A 168	None	1.46A	20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1RR8_A_TTCA100_1 (DNA TOPOISOMERASE I)	3fed	GLUTAMATE CARBOXYPEPTIDASE III (Homo sapiens)	4 / 5	GLU A 415 ARG A 524 ASP A 455 THR A 528	ZN  A1751 ( 1.9A) BIX  A   1 ( 3.1A) None None	1.13A	24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1RR8_A_TTCA100_1 (DNA TOPOISOMERASE I)	4hzh	PROTHROMBIN (Homo sapiens)	4 / 5	GLU A 226 ARG A 418 ASP A 417 THR A 186	None	1.31A	20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1RR8_A_TTCA100_1 (DNA TOPOISOMERASE I)	4hzh	PROTHROMBIN (Homo sapiens)	4 / 5	GLU A 250 ARG A 418 ASP A 417 THR A 186	None	1.21A	20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1RR8_A_TTCA100_1 (DNA TOPOISOMERASE I)	5jtv	UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 7 (Homo sapiens)	4 / 5	GLU A 317 ARG A 325 LYS A 327 ASP A 346	None	1.49A	21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1RR8_A_TTCA100_1 (DNA TOPOISOMERASE I)	5n7f	MEMBRANE-ASSOCIATED GUANYLATE KINASE, WW AND PDZ DOMAIN-CONTAINING PROTEIN 1,ANNEXIN A2 (Homo sapiens)	4 / 5	GLU A 575 ARG A 554 ASP A 517 THR A 473	None	1.16A	21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1RR8_A_TTCA100_1 (DNA TOPOISOMERASE I)	5vho	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 10 26S PROTEASOME REGULATORY SUBUNIT 6B (Homo sapiens)	4 / 5	GLU G 187 ARG D 338 LYS D 369 ASP D 368	None	1.37A	16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1RRJ_B_TTCB990_1 (DNA TOPOISOMERASE I)	1z8l	GLUTAMATE CARBOXYPEPTIDASE II (Homo sapiens)	4 / 5	GLU A 425 ARG A 534 ASP A 465 THR A 538	ZN  A1752 (-2.5A) None None None	1.03A	22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1RRJ_B_TTCB990_1 (DNA TOPOISOMERASE I)	2wd9	ACYL-COENZYME A SYNTHETASE ACSM2A, MITOCHONDRIAL (Homo sapiens)	4 / 5	GLU A 477 ARG A 461 ASP A 446 THR A 366	None	1.19A	21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1RRJ_B_TTCB990_1 (DNA TOPOISOMERASE I)	3dzu	PEROXISOME PROLIFERATOR-ACTIVAT ED RECEPTOR GAMMA RETINOIC ACID RECEPTOR RXR-ALPHA (Homo sapiens)	4 / 5	GLU A 207 ARG A 202 ASP D 337 THR A 168	None	1.46A	20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1RRJ_B_TTCB990_1 (DNA TOPOISOMERASE I)	3fed	GLUTAMATE CARBOXYPEPTIDASE III (Homo sapiens)	4 / 5	GLU A 415 ARG A 524 ASP A 455 THR A 528	ZN  A1751 ( 1.9A) BIX  A   1 ( 3.1A) None None	1.09A	24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1RRJ_B_TTCB990_1 (DNA TOPOISOMERASE I)	3hig	AMILORIDE-SENSITIVE AMINE OXIDASE (Homo sapiens)	4 / 5	GLU A 393 ARG A 453 LYS A 478 ASP A 466	None	1.29A	20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1RRJ_B_TTCB990_1 (DNA TOPOISOMERASE I)	4hzh	PROTHROMBIN (Homo sapiens)	4 / 5	GLU A 226 ARG A 418 ASP A 417 THR A 186	None	1.31A	21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1RRJ_B_TTCB990_1 (DNA TOPOISOMERASE I)	4hzh	PROTHROMBIN (Homo sapiens)	4 / 5	GLU A 250 ARG A 418 ASP A 417 THR A 186	None	1.22A	21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1RRJ_B_TTCB990_1 (DNA TOPOISOMERASE I)	5n7f	MEMBRANE-ASSOCIATED GUANYLATE KINASE, WW AND PDZ DOMAIN-CONTAINING PROTEIN 1,ANNEXIN A2 (Homo sapiens)	4 / 5	GLU A 575 ARG A 554 ASP A 517 THR A 473	None	1.16A	21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1RRJ_B_TTCB990_1 (DNA TOPOISOMERASE I)	5vho	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 10 26S PROTEASOME REGULATORY SUBUNIT 6B (Homo sapiens)	4 / 5	GLU G 187 ARG D 338 LYS D 369 ASP D 368	None	1.36A	16.78