POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA2)		2abj BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE,
CYTOSOLIC
(Homo
sapiens)		4 / 6SER A 227
GLY A 281
ASP A 218
GLY A 214
None
0.82A20.98
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA2)		2o8e DNA MISMATCH REPAIR
PROTEIN MSH6
(Homo
sapiens)		4 / 6SER B 714
ARG B 581
GLY B 557
GLY B 571
None
0.89A18.70
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA2)		3kyd SUMO-ACTIVATING
ENZYME SUBUNIT 2
(Homo
sapiens)		4 / 6SER B  79
GLY B  24
ASP B  48
GLY B  27
None
1.04A22.26
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA2)		4kaq RITUXIMAB HEAVY
CHAIN
(Homo
sapiens;
Mus
musculus)		4 / 6SER H  99
GLY H  56
ASP H  57
GLY H  54
None
0.98A16.84
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA2)		5neu INTEGRIN ALPHA-V
(Homo
sapiens)		5 / 6SER A 185
ARG A 168
GLY A 235
ASP A 234
GLY A 229
None
1.24A23.88
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA2)		5th6 MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens)		4 / 6ARG A 106
GLY A 112
ASP A 113
GLY A 195
None
0.88A18.15
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA2)		6fn1 HUMAN-MOUSE CHIMERIC
ABCB1 (ABCBHM)
(Homo
sapiens)		4 / 6SER A1234
ARG A1232
GLY A1178
ASP A1206
None
0.95A10.55
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA4)		1ex0 COAGULATION FACTOR
XIII A CHAIN
(Homo
sapiens)		4 / 7GLY A 473
ASP A 472
GLY A 470
GLU A 203
None
0.75A21.26
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA4)		1gq4 EZRIN-RADIXIN-MOESIN
BINDING
PHOSPHOPROTEIN-50
(Homo
sapiens)		4 / 7ARG A  80
GLY A  23
GLY A  25
GLU A  43
None
0.82A12.27
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA4)		2o8e DNA MISMATCH REPAIR
PROTEIN MSH6
(Homo
sapiens)		4 / 7ARG B 581
SER B 714
GLY B 557
GLY B 571
None
0.91A18.70
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA4)		5gwj DNA TOPOISOMERASE
2-BETA
(Homo
sapiens)		4 / 7GLY A 478
ASP A 479
GLY A 504
GLU A 522
N2W  A1302 ( 3.0A)
N2W  A1302 ( 3.4A)
N2W  A1302 ( 4.4A)
None
0.78A21.86
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA4)		5neu INTEGRIN ALPHA-V
(Homo
sapiens)		5 / 7ARG A 168
SER A 185
GLY A 235
ASP A 234
GLY A 229
None
1.22A23.88
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA4)		5th6 MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens)		4 / 7ARG A 106
GLY A 112
ASP A 113
GLY A 195
None
0.90A18.15
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA4)		6fn1 HUMAN-MOUSE CHIMERIC
ABCB1 (ABCBHM)
(Homo
sapiens)		4 / 7ARG A1232
SER A1234
GLY A1178
ASP A1206
None
0.91A10.55
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_F_TR6F101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		1eq3 PEPTIDYL-PROLYL
CIS/TRANS ISOMERASE
(PPIASE)
(Homo
sapiens)		4 / 5GLY A  83
ARG A  41
GLY A 129
GLU A 128
None
1.25A11.68
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_F_TR6F101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		1fsu N-ACETYLGALACTOSAMIN
E-4-SULFATASE
(Homo
sapiens)		4 / 5GLY A 328
ARG A 327
GLY A 324
GLU A 323
None
1.14A20.58
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_F_TR6F101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		1fsu N-ACETYLGALACTOSAMIN
E-4-SULFATASE
(Homo
sapiens)		4 / 5GLY A 328
ARG A 327
GLY A 325
GLU A 323
None
1.14A20.58
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_F_TR6F101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		3b7x FK506-BINDING
PROTEIN 6
(Homo
sapiens)		4 / 5GLY A  48
ARG A 103
GLY A  46
GLU A 106
None
1.24A16.63
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_F_TR6F101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		3vzg ZYMOGEN GRANULE
MEMBRANE PROTEIN 16
(Homo
sapiens)		4 / 5GLY A  34
ARG A 145
GLY A  31
GLU A  29
MAN  A 202 ( 3.7A)
None
None
None
1.26A14.94
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_F_TR6F101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		4bv6 APOPTOSIS-INDUCING
FACTOR 1,
MITOCHONDRIAL
(Homo
sapiens)		4 / 5GLY A 462
ARG A 463
GLY A 466
GLU A 467
None
0.95A22.28
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_F_TR6F101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens)		4 / 5GLY A 570
ARG A 569
GLY A 568
GLU A 574
GUI  A 901 (-3.4A)
None
GUI  A 901 ( 4.3A)
None
1.27A21.98
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_F_TR6F101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		5gwj DNA TOPOISOMERASE
2-BETA
(Homo
sapiens)		4 / 5GLY A 478
ARG A 503
GLY A 504
GLU A 522
N2W  A1302 ( 3.0A)
N2S  A1301 ( 3.9A)
N2W  A1302 ( 4.4A)
None
0.95A21.10
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_F_TR6F101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		5u9k ARYL HYDROCARBON
RECEPTOR-INTERACTING
PROTEIN-LIKE 1
(AIPL1)
(Homo
sapiens)		4 / 5GLY A  22
ARG A  80
GLY A  20
GLU A  83
None
1.13A15.13
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_H_TR6H101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		1snx TYROSINE-PROTEIN
KINASE ITK/TSK
(Homo
sapiens)		3 / 5GLY A 372
GLY A 370
GLU A 368
None
0.48A19.92
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_H_TR6H101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		1vzo RIBOSOMAL PROTEIN S6
KINASE ALPHA 5
(Homo
sapiens)		3 / 5GLY A  56
GLY A  58
GLU A 138
None
0.29A23.15
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_H_TR6H101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		2yrv AT-RICH INTERACTIVE
DOMAIN-CONTAINING
PROTEIN 4A
(Homo
sapiens)		3 / 5GLY A 117
GLY A 113
GLU A 111
None
0.50A12.99
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_H_TR6H101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		3hf8 TRYPTOPHAN
5-HYDROXYLASE 1
(Homo
sapiens)		3 / 5GLY A 276
GLY A 333
GLU A 317
None
ML0  A 401 (-3.9A)
FE  A 400 ( 1.9A)
0.46A20.39
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_H_TR6H101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		3v4p INTEGRIN ALPHA-4
(Homo
sapiens)		3 / 5GLY A 304
GLY A 336
GLU A 337
None
0.52A21.63
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_H_TR6H101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		4ymd COLLECTIN-11
(Homo
sapiens)		3 / 5GLY A 249
GLY A 187
GLU A 183
None
0.47A15.45
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_H_TR6H101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		5eod COAGULATION FACTOR
XI
(Homo
sapiens)		3 / 5GLY A 326
GLY A 324
GLU A 323
None
0.46A23.04
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_H_TR6H101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		5l01 TRYPTOPHAN
5-HYDROXYLASE 1
(Homo
sapiens)		3 / 5GLY A 276
GLY A 333
GLU A 317
None
6Z4  A 502 (-3.9A)
FE  A 501 ( 1.8A)
0.44A21.69
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_H_TR6H101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		5nv6 TRANSFORMING GROWTH
FACTOR-BETA-INDUCED
PROTEIN IG-H3
(Homo
sapiens)		3 / 5GLY A 623
GLY A 535
GLU A 534
None
0.46A22.78
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		2abj BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE,
CYTOSOLIC
(Homo
sapiens)		4 / 6GLY A 281
ASP A 218
GLY A 214
SER A 227
None
0.83A19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		2o8e DNA MISMATCH REPAIR
PROTEIN MSH6
(Homo
sapiens)		4 / 6GLY B 557
GLY B 571
SER B 714
ARG B 581
None
0.87A21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		3v4y SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PP1-ALPHA CATALYTIC
SUBUNIT
(Homo
sapiens)		4 / 6GLY A  63
GLY A  91
SER A 207
ARG A 246
None
1.03A18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		4kaq RITUXIMAB HEAVY
CHAIN
(Homo
sapiens;
Mus
musculus)		4 / 6GLY H  56
ASP H  57
GLY H  54
SER H  99
None
1.03A13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		5neu INTEGRIN ALPHA-V
(Homo
sapiens)		5 / 6GLY A 235
ASP A 234
GLY A 229
SER A 185
ARG A 168
None
1.18A23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		5th6 MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens)		4 / 6GLY A 112
ASP A 113
GLY A 195
ARG A 106
None
0.75A16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		1ex0 COAGULATION FACTOR
XIII A CHAIN
(Homo
sapiens)		4 / 7GLY A 473
ASP A 472
GLY A 470
GLU A 203
None
0.86A23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		1gq4 EZRIN-RADIXIN-MOESIN
BINDING
PHOSPHOPROTEIN-50
(Homo
sapiens)		4 / 7ARG A  80
GLY A  23
GLY A  25
GLU A  43
None
0.83A8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		2dvj V-CRK SARCOMA VIRUS
CT10 ONCOGENE
HOMOLOG, ISOFORM A
(Homo
sapiens)		4 / 7GLY A 126
GLY A 124
GLU A 149
SER A  52
None
0.92A16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		2o8e DNA MISMATCH REPAIR
PROTEIN MSH6
(Homo
sapiens)		4 / 7ARG B 581
GLY B 557
GLY B 571
SER B 714
None
0.92A21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		5gwj DNA TOPOISOMERASE
2-BETA
(Homo
sapiens)		4 / 7GLY A 478
ASP A 479
GLY A 504
GLU A 522
N2W  A1302 ( 3.0A)
N2W  A1302 ( 3.4A)
N2W  A1302 ( 4.4A)
None
0.82A28.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		5neu INTEGRIN ALPHA-V
(Homo
sapiens)		5 / 7ARG A 168
GLY A 235
ASP A 234
GLY A 229
SER A 185
None
1.22A23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		5th6 MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens)		4 / 7ARG A 106
GLY A 112
ASP A 113
GLY A 195
None
0.92A16.17