POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Seq. Identity (%)	View	Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3VN2_A_TLSA501_1 (PEROXISOME PROLIFERATOR-ACTIVAT ED RECEPTOR GAMMA)	2p54	PEROXISOME PROLIFERATOR-ACTIVAT ED RECEPTOR ALPHA (Homo sapiens)	9 / 12	PHE A 273 CYH A 276 SER A 280 ILE A 317 LEU A 321 LEU A 344 MET A 355 HIS A 440 TYR A 464	735  A 469 (-3.7A) 735  A 469 (-2.9A) 735  A 469 (-2.8A) 735  A 469 ( 4.8A) 735  A 469 ( 4.3A) 735  A 469 ( 4.2A) 735  A 469 (-2.9A) 735  A 469 (-4.0A) 735  A 469 (-4.6A)	0.51A	61.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3VN2_A_TLSA501_1 (PEROXISOME PROLIFERATOR-ACTIVAT ED RECEPTOR GAMMA)	2p8u	HYDROXYMETHYLGLUTARY L-COA SYNTHASE, CYTOPLASMIC (Homo sapiens)	5 / 12	PHE A 327 HIS A 264 LEU A 383 LEU A 255 MET A 278	None SCY  A 129 ( 3.7A) None None None	1.36A	22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3VN2_A_TLSA501_1 (PEROXISOME PROLIFERATOR-ACTIVAT ED RECEPTOR GAMMA)	2uw2	RIBONUCLEOSIDE-DIPHO SPHATE REDUCTASE M2 SUBUNIT (Homo sapiens)	5 / 12	PHE A 244 SER A 258 HIS A 172 TYR A 176 LEU A 131	None	1.23A	22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3VN2_A_TLSA501_1 (PEROXISOME PROLIFERATOR-ACTIVAT ED RECEPTOR GAMMA)	3a77	INTERFERON REGULATORY FACTOR 3 (Homo sapiens)	5 / 12	CYH A 371 LEU A 196 LEU A 281 PHE A 325 TYR A 408	None	1.45A	20.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3VN2_A_TLSA501_1 (PEROXISOME PROLIFERATOR-ACTIVAT ED RECEPTOR GAMMA)	3b0q	PEROXISOME PROLIFERATOR-ACTIVAT ED RECEPTOR GAMMA (Homo sapiens)	9 / 12	CYH A 285 SER A 289 ILE A 326 TYR A 327 LEU A 330 LEU A 353 MET A 364 HIS A 449 TYR A 473	MC5  A   1 (-3.6A) MC5  A   1 (-2.6A) MC5  A   1 ( 4.9A) None MC5  A   1 (-4.4A) MC5  A   1 (-4.7A) MC5  A   1 (-3.7A) MC5  A   1 (-3.9A) MC5  A   1 (-4.9A)	0.72A	100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3VN2_A_TLSA501_1 (PEROXISOME PROLIFERATOR-ACTIVAT ED RECEPTOR GAMMA)	3b0q	PEROXISOME PROLIFERATOR-ACTIVAT ED RECEPTOR GAMMA (Homo sapiens)	5 / 12	PHE A 282 CYH A 285 SER A 289 ILE A 326 TYR A 473	MC5  A   1 (-4.4A) MC5  A   1 (-3.6A) MC5  A   1 (-2.6A) MC5  A   1 ( 4.9A) MC5  A   1 (-4.9A)	0.85A	100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3VN2_A_TLSA501_1 (PEROXISOME PROLIFERATOR-ACTIVAT ED RECEPTOR GAMMA)	3b0q	PEROXISOME PROLIFERATOR-ACTIVAT ED RECEPTOR GAMMA (Homo sapiens)	5 / 12	SER A 289 ILE A 326 LEU A 330 PHE A 282 TYR A 473	MC5  A   1 (-2.6A) MC5  A   1 ( 4.9A) MC5  A   1 (-4.4A) MC5  A   1 (-4.4A) MC5  A   1 (-4.9A)	1.20A	100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3VN2_A_TLSA501_1 (PEROXISOME PROLIFERATOR-ACTIVAT ED RECEPTOR GAMMA)	3d5f	PEROXISOME PROLIFERATOR-ACTIVAT ED RECEPTOR DELTA (Homo sapiens)	7 / 12	PHE A 282 CYH A 285 ILE A 326 LEU A 330 LEU A 353 HIS A 449 TYR A 473	L41  A 501 ( 4.9A) L41  A 501 (-3.5A) None L41  A 501 (-4.9A) None L41  A 501 (-3.9A) L41  A 501 (-4.8A)	0.61A	62.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3VN2_A_TLSA501_1 (PEROXISOME PROLIFERATOR-ACTIVAT ED RECEPTOR GAMMA)	3dzu	PEROXISOME PROLIFERATOR-ACTIVAT ED RECEPTOR GAMMA (Homo sapiens)	7 / 12	PHE D 282 CYH D 285 TYR D 327 LEU D 330 LEU D 353 MET D 364 HIS D 449	None PLB  D 701 (-3.2A) None PLB  D 701 ( 4.1A) None PLB  D 701 ( 4.8A) None	1.03A	93.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3VN2_A_TLSA501_1 (PEROXISOME PROLIFERATOR-ACTIVAT ED RECEPTOR GAMMA)	3dzu	PEROXISOME PROLIFERATOR-ACTIVAT ED RECEPTOR GAMMA (Homo sapiens)	10 / 12	PHE D 282 SER D 289 HIS D 323 ILE D 326 TYR D 327 LEU D 330 LEU D 353 MET D 364 HIS D 449 TYR D 473	None PLB  D 701 ( 3.9A) None PLB  D 701 ( 4.5A) None PLB  D 701 ( 4.1A) None PLB  D 701 ( 4.8A) None None	0.86A	93.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3VN2_A_TLSA501_1 (PEROXISOME PROLIFERATOR-ACTIVAT ED RECEPTOR GAMMA)	3dzu	PEROXISOME PROLIFERATOR-ACTIVAT ED RECEPTOR GAMMA (Homo sapiens)	6 / 12	SER D 289 HIS D 323 ILE D 326 LEU D 330 PHE D 282 TYR D 473	PLB  D 701 ( 3.9A) None PLB  D 701 ( 4.5A) PLB  D 701 ( 4.1A) None None	1.31A	93.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3VN2_A_TLSA501_1 (PEROXISOME PROLIFERATOR-ACTIVAT ED RECEPTOR GAMMA)	3hf1	RIBONUCLEOSIDE-DIPHO SPHATE REDUCTASE SUBUNIT M2 B (Homo sapiens)	5 / 12	PHE A 206 SER A 220 HIS A 134 TYR A 138 LEU A  93	None	1.28A	24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3VN2_A_TLSA501_1 (PEROXISOME PROLIFERATOR-ACTIVAT ED RECEPTOR GAMMA)	3jd8	NIEMANN-PICK C1 PROTEIN (Homo sapiens)	5 / 12	ILE A 437 TYR A 509 LEU A 440 LEU A 547 HIS A 510	None	1.29A	11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3VN2_A_TLSA501_1 (PEROXISOME PROLIFERATOR-ACTIVAT ED RECEPTOR GAMMA)	3ll8	SERINE/THREONINE-PRO TEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM (Homo sapiens)	5 / 12	CYH A  88 SER A 307 HIS A  92 LEU A  98 LEU A 144	None None FE  A 506 ( 3.3A) None None	1.32A	21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3VN2_A_TLSA501_1 (PEROXISOME PROLIFERATOR-ACTIVAT ED RECEPTOR GAMMA)	3vpo	RIBONUCLEOSIDE-DIPHO SPHATE REDUCTASE SUBUNIT M2 (Homo sapiens)	5 / 12	PHE A 244 SER A 258 HIS A 172 TYR A 176 LEU A 131	None	1.19A	23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3VN2_A_TLSA501_1 (PEROXISOME PROLIFERATOR-ACTIVAT ED RECEPTOR GAMMA)	4djn	RIBONUCLEOSIDE-DIPHO SPHATE REDUCTASE SUBUNIT M2 B (Homo sapiens)	5 / 12	PHE A 206 SER A 220 HIS A 134 TYR A 138 LEU A  93	None	1.24A	23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3VN2_A_TLSA501_1 (PEROXISOME PROLIFERATOR-ACTIVAT ED RECEPTOR GAMMA)	4gqb	PROTEIN ARGININE N-METHYLTRANSFERASE 5 (Homo sapiens)	5 / 12	SER A 199 ILE A 142 LEU A 138 LEU A 126 MET A 153	None	1.36A	20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3VN2_A_TLSA501_1 (PEROXISOME PROLIFERATOR-ACTIVAT ED RECEPTOR GAMMA)	4hl4	TBC1 DOMAIN FAMILY MEMBER 20 (Homo sapiens)	5 / 12	HIS A 147 ILE A 130 TYR A 142 LEU A 134 MET A 178	None	1.47A	24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3VN2_A_TLSA501_1 (PEROXISOME PROLIFERATOR-ACTIVAT ED RECEPTOR GAMMA)	4irq	BETA-1,4-GALACTOSYLT RANSFERASE 7 (Homo sapiens)	5 / 12	HIS A 184 ILE A 203 LEU A 258 HIS A 191 TYR A 199	None None None None TRS  A 403 (-4.9A)	1.33A	19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3VN2_A_TLSA501_1 (PEROXISOME PROLIFERATOR-ACTIVAT ED RECEPTOR GAMMA)	4kf6	GLYCOLIPID TRANSFER PROTEIN DOMAIN-CONTAINING PROTEIN 1 (Homo sapiens)	5 / 12	CYH A 138 SER A 141 HIS A 116 LEU A 122 LEU A  46	None	1.25A	21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3VN2_A_TLSA501_1 (PEROXISOME PROLIFERATOR-ACTIVAT ED RECEPTOR GAMMA)	4ora	SERINE/THREONINE-PRO TEIN PHOSPHATASE 2B CATALYTIC SUBUNIT BETA ISOFORM (Homo sapiens)	5 / 12	CYH A  97 SER A 316 HIS A 101 LEU A 107 LEU A 153	None None FE  A 602 (-3.9A) None None	1.19A	19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3VN2_A_TLSA501_1 (PEROXISOME PROLIFERATOR-ACTIVAT ED RECEPTOR GAMMA)	4zzy	POLY [ADP-RIBOSE] POLYMERASE 2 (Homo sapiens)	5 / 12	CYH A 367 HIS A 361 ILE A 242 LEU A 241 LEU A 486	None	1.10A	22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3VN2_A_TLSA501_1 (PEROXISOME PROLIFERATOR-ACTIVAT ED RECEPTOR GAMMA)	5dsy	POLY [ADP-RIBOSE] POLYMERASE 2 (Homo sapiens)	5 / 12	CYH A 354 HIS A 348 ILE A 229 LEU A 228 LEU A 473	None	1.14A	25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3VN2_A_TLSA501_1 (PEROXISOME PROLIFERATOR-ACTIVAT ED RECEPTOR GAMMA)	5hns	NIEMANN-PICK C1 PROTEIN (Homo sapiens)	5 / 12	ILE A 437 TYR A 509 LEU A 440 LEU A 547 HIS A 510	None	1.39A	24.91