POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		1n76 LACTOFERRIN
(Homo
sapiens)		4 / 7HIS A 246
ALA A 248
TYR A 324
ALA A 327
None
0.39A41.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		1n76 LACTOFERRIN
(Homo
sapiens)		5 / 7ILE A 471
LEU A 475
HIS A 590
ALA A 592
TYR A 667
None
0.67A41.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		1ryo SEROTRANSFERRIN
(Homo
sapiens)		6 / 7ILE A 130
LEU A 134
HIS A 242
ALA A 244
TYR A 319
ALA A 322
None
0.58A42.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		1suv SEROTRANSFERRIN,
C-LOBE
(Homo
sapiens)		6 / 7ILE E 461
LEU E 465
HIS E 575
ALA E 577
TYR E 652
ALA E 655
None
0.55A58.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		2hau SEROTRANSFERRIN
(Homo
sapiens)		4 / 7ILE A 130
LEU A 134
HIS A 242
ALA A 244
None
0.63A32.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		3kv6 JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION
PROTEIN 1D
(Homo
sapiens)		4 / 7HIS A 354
ALA A 355
VAL A 356
ALA A 117
FE2  A 491 (-3.4A)
None
AKG  A 702 (-4.0A)
None
0.61A22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		3u78 LYSINE-SPECIFIC
DEMETHYLASE 7
(Homo
sapiens)		4 / 7HIS A 354
ALA A 355
VAL A 356
ALA A 117
 NI  A 702 ( 3.5A)
None
AKG  A 701 (-4.1A)
None
0.70A23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		5mqi PROTEIN TIMELESS
HOMOLOG,PROTEIN
TIMELESS HOMOLOG
(Homo
sapiens)		4 / 7ILE A 411
LEU A 415
ALA A 442
TYR A 378
None
0.69A20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		5v1b EGL NINE HOMOLOG 2
(Homo
sapiens)		4 / 7ILE A 191
LEU A 348
ALA A 338
VAL A 337
None
0.81A19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		1dle COMPLEMENT FACTOR B
(Homo
sapiens)		5 / 12VAL A  47
LEU A 181
VAL A 212
GLY A 211
LEU A 123
None
0.96A19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		1l1f GLUTAMATE
DEHYDROGENASE 1
(Homo
sapiens)		5 / 12VAL A 121
LEU A 457
VAL A 382
GLY A 380
ALA A 379
None
1.07A21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		1rtk COMPLEMENT FACTOR B
(Homo
sapiens)		5 / 12VAL A 491
LEU A 656
VAL A 691
GLY A 690
LEU A 572
None
0.90A20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		2zec TRYPTASE BETA 2
(Homo
sapiens)		5 / 12VAL A  61
VAL A  54
VAL A 226
GLY A 211
LEU A  33
None
0.90A16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		3nmz APC VARIANT PROTEIN
(Homo
sapiens)		5 / 12VAL A 642
VAL A 609
GLY A 611
ALA A 612
LEU A 616
None
1.09A20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		4yk6 ADENOMATOUS
POLYPOSIS COLI
PROTEIN
(Homo
sapiens)		5 / 12VAL A 642
VAL A 609
GLY A 611
ALA A 612
LEU A 616
None
1.01A21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		4ztu DNA POLYMERASE
SUBUNIT GAMMA-2,
MITOCHONDRIAL
(Homo
sapiens)		5 / 12VAL B 104
ARG B 107
LEU B 185
VAL B 213
GLY B 212
None
1.13A21.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens)		12 / 12VAL A 116
ARG A 120
VAL A 349
SER A 353
TYR A 355
LEU A 384
TRP A 387
MET A 522
VAL A 523
GLY A 526
ALA A 527
LEU A 531
None
ID8  A 601 ( 4.4A)
ID8  A 601 (-3.9A)
ID8  A 601 ( 4.7A)
ID8  A 601 (-3.8A)
ID8  A 601 ( 4.8A)
COH  A 602 (-4.5A)
ID8  A 601 (-4.2A)
ID8  A 601 (-3.6A)
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
0.32A100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		1ly7 FRATAXIN
(Homo
sapiens)		3 / 3LEU A 185
TYR A 143
SER A 160
None
0.86A11.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		1orf GRANZYME A
(Homo
sapiens)		3 / 3LEU A 155
TYR A  29
SER A 197
None
0.90A18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		2l29 INSULIN-LIKE GROWTH
FACTOR 2 RECEPTOR
VARIANT
(Homo
sapiens)		3 / 3LEU A1629
TYR A1606
SER A1600
None
0.89A12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		2yyo SPRY
DOMAIN-CONTAINING
PROTEIN 3
(Homo
sapiens)		3 / 3LEU A 161
TYR A  30
SER A  33
None
0.82A15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		2z66 VARIABLE LYMPHOCYTE
RECEPTOR B,
TOLL-LIKE RECEPTOR 4
(Eptatretus
burgeri;
Homo
sapiens)		3 / 3LEU A 511
TYR A 551
SER A 534
None
0.83A20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		3h1v GLUCOKINASE
(Homo
sapiens)		3 / 3LEU X  45
TYR X 234
SER X 396
None
0.89A21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		3rc3 ATP-DEPENDENT RNA
HELICASE SUPV3L1,
MITOCHONDRIAL
(Homo
sapiens)		3 / 3LEU A 361
TYR A 441
SER A 380
None
0.84A20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		4jy4 PGT121 HEAVY CHAIN
(Homo
sapiens)		3 / 3LEU B  63
TYR B  90
SER B  40
None
0.85A17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		4zrq TRANSCOBALAMIN-2
(Homo
sapiens)		3 / 3LEU A 358
TYR A  62
SER A  83
CNC  A 501 (-3.6A)
None
CNC  A 501 ( 4.3A)
0.89A21.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IKT_A_TLFA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens)		3 / 3LEU A 352
TYR A 385
SER A 530
ID8  A 601 (-4.1A)
ID8  A 601 ( 3.5A)
ID8  A 601 (-2.7A)
0.06A100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		5lf7 PROTEASOME SUBUNIT
BETA TYPE-1
(Homo
sapiens)		3 / 3LEU L  62
TYR L  44
SER L  40
None
0.86A17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		5lxd DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 2
(Homo
sapiens)		3 / 3LEU A 200
TYR A 301
SER A 299
None
0.79A22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		5veu CYTOCHROME P450 3A5
(Homo
sapiens)		3 / 3LEU A 211
TYR A 307
SER A 312
None
0.90A23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		1itu RENAL DIPEPTIDASE
(Homo
sapiens)		5 / 12VAL A 247
LEU A 246
GLY A 279
ALA A 278
LEU A 237
None
1.30A20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		1l1f GLUTAMATE
DEHYDROGENASE 1
(Homo
sapiens)		5 / 12VAL A 121
LEU A 457
VAL A 382
GLY A 380
ALA A 379
None
1.05A21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		1nty TRIPLE FUNCTIONAL
DOMAIN PROTEIN
(Homo
sapiens)		5 / 12VAL A1458
LEU A1457
SER A1456
TRP A1523
LEU A1411
None
1.22A19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		1nty TRIPLE FUNCTIONAL
DOMAIN PROTEIN
(Homo
sapiens)		5 / 12VAL A1458
LEU A1457
SER A1456
TRP A1523
LEU A1414
None
1.23A19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		2iag PROSTACYCLIN
SYNTHASE
(Homo
sapiens)		5 / 12VAL A 458
LEU A 345
LEU A 485
ALA A 292
LEU A 296
None
1.25A21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		2w9z G1/S-SPECIFIC
CYCLIN-D1
(Homo
sapiens)		5 / 12VAL A  67
LEU A  85
GLY A 103
ALA A 104
LEU A 124
None
1.35A19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		3naf CALCIUM-ACTIVATED
POTASSIUM CHANNEL
SUBUNIT
ALPHA-1,CALCIUM-ACTI
VATED POTASSIUM
CHANNEL SUBUNIT
ALPHA-1,CALCIUM-ACTI
VATED POTASSIUM
CHANNEL SUBUNIT
ALPHA-1
(Homo
sapiens)		5 / 12VAL A 719
LEU A 503
GLY A 492
ALA A 495
LEU A 741
None
1.17A19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		4ifp MALTOSE-BINDING
PERIPLASMIC
PROTEIN,NACHT, LRR
AND PYD
DOMAINS-CONTAINING
PROTEIN 1
(Escherichia
coli;
Homo
sapiens)		5 / 12VAL A 344
LEU A 161
GLY A 188
ALA A 189
LEU A 362
None
1.18A20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		4yk6 ADENOMATOUS
POLYPOSIS COLI
PROTEIN
(Homo
sapiens)		5 / 12VAL A 642
VAL A 609
GLY A 611
ALA A 612
LEU A 616
None
1.00A21.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens)		12 / 12VAL A 116
ARG A 120
VAL A 349
LEU A 352
SER A 353
LEU A 384
TRP A 387
MET A 522
VAL A 523
GLY A 526
ALA A 527
LEU A 531
None
ID8  A 601 ( 4.4A)
ID8  A 601 (-3.9A)
ID8  A 601 (-4.1A)
ID8  A 601 ( 4.7A)
ID8  A 601 ( 4.8A)
COH  A 602 (-4.5A)
ID8  A 601 (-4.2A)
ID8  A 601 (-3.6A)
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
0.20A100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		5wq6 MBP TAGGED HMNDA-PYD
(Homo
sapiens)		5 / 12VAL A 344
LEU A 161
GLY A 188
ALA A 189
LEU A 362
None
1.23A20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		5xjy ATP-BINDING CASSETTE
SUB-FAMILY A MEMBER
1
(Homo
sapiens)		5 / 12VAL A1769
VAL A1673
LEU A1676
TRP A1699
ALA A1756
None
1.19A13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		6fn1 HUMAN-MOUSE CHIMERIC
ABCB1 (ABCBHM)
(Homo
sapiens)		5 / 12VAL A1059
VAL A1078
LEU A1081
VAL A1093
LEU A1057
None
1.00Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		1adq IGM-LAMBDA RF-AN FAB
(HEAVY CHAIN)
(Homo
sapiens)		3 / 3TYR H  90
TYR H 185
SER H 112
None
1.00A18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT
(Homo
sapiens)		3 / 3TYR A 357
TYR A 176
SER A  26
None
0.95A20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		2q6z UROPORPHYRINOGEN
DECARBOXYLASE
(Homo
sapiens)		3 / 3TYR A 342
TYR A 164
SER A 219
None
0.75A20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		3c5h GLUCOCORTICOID
RECEPTOR DNA-BINDING
FACTOR 1
(Homo
sapiens)		3 / 3TYR A 116
TYR A 133
SER A  36
None
None
MG  A 302 ( 2.1A)
0.94A18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		3qvu SULFOTRANSFERASE 1A1
(Homo
sapiens)		3 / 3TYR A 280
TYR A 127
SER A  49
None
0.98A19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		4n78 CYTOPLASMIC
FMR1-INTERACTING
PROTEIN 1
(Homo
sapiens)		3 / 3TYR A 443
TYR A 671
SER A 667
None
0.96A18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		4odh CAP256-VRC26.UCA
HEAVY CHAIN
(Homo
sapiens)		3 / 3TYR H  90
TYR H 176
SER H 112
None
0.83A17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		4rwf MALTOSE TRANSPORTER
SUBUNIT, RECEPTOR
ACTIVITY-MODIFYING
PROTEIN 2,
CALCITONIN
GENE-RELATED PEPTIDE
TYPE 1 RECEPTOR
FUSION PROTEIN
ADRENOMEDULLIN
(Escherichia
coli;
Homo
sapiens;
Homo
sapiens)		3 / 3TYR A 343
TYR B  52
SER B  45
None
0.85A19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		4s0v HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE
(Homo
sapiens;
Pyrococcus
abyssi)		3 / 3TYR A 364
TYR A 317
SER A 141
None
0.92A21.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IKT_B_TLFB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens)		3 / 3TYR A 355
TYR A 385
SER A 530
ID8  A 601 (-3.8A)
ID8  A 601 ( 3.5A)
ID8  A 601 (-2.7A)
0.13A100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		5khp NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN
(Homo
sapiens)		3 / 3TYR A 100
TYR A  56
SER A  68
None
0.78A17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		5nvm EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E
TYPE 2
(Homo
sapiens)		3 / 3TYR A  78
TYR A  64
SER A 111
None
0.98A15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		1p32 MITOCHONDRIAL MATRIX
PROTEIN, SF2P32
(Homo
sapiens)		5 / 12VAL A 183
PHE A 204
TRP A 109
VAL A 169
PHE A 168
None
1.01A18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		1ujs ACTIN-BINDING LIM
PROTEIN HOMOLOGUE
(Homo
sapiens)		5 / 12PHE A  57
PHE A  64
ILE A  61
VAL A  56
PHE A  53
None
1.21A17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		2iik 3-KETOACYL-COA
THIOLASE,
PEROXISOMAL
(Homo
sapiens)		5 / 12VAL A 367
PHE A 203
ILE A 195
VAL A 189
VAL A 357
None
1.33A22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		2mmy TATA-BINDING
PROTEIN-ASSOCIATED
FACTOR 2N
(Homo
sapiens)		5 / 12PHE A 253
PHE A 290
ILE A 236
VAL A 315
PHE A 303
None
1.28A15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		2p5x N-ACETYLSEROTONIN
O-METHYLTRANSFERASE-
LIKE PROTEIN
(Homo
sapiens)		5 / 12PHE A  35
ILE A  85
VAL A 125
SER A  19
VAL A  37
None
None
None
PO4  A 301 (-2.3A)
None
0.91A21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		3rpx COMPLEMENT COMPONENT
1 Q
SUBCOMPONENT-BINDING
PROTEIN
(Homo
sapiens)		5 / 12VAL A 183
PHE A 204
TRP A 109
VAL A 169
PHE A 168
None
UNX  A  60 ( 4.7A)
None
None
None
1.03A20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		4cyf PANTETHEINASE
(Homo
sapiens)		5 / 12VAL A 224
PHE A 234
PHE A 250
VAL A 260
PHE A 262
None
CSO  A 211 ( 4.0A)
None
None
None
1.30A18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		4dlo BRAIN-SPECIFIC
ANGIOGENESIS
INHIBITOR 3
(Homo
sapiens)		5 / 12VAL A 620
PHE A 630
ILE A 684
VAL A 685
VAL A 677
None
1.10A19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		4ono BETA-2-MICROGLOBULIN
/T-CELL SURFACE
GLYCOPROTEIN
CD1C/T-CELL SURFACE
GLYCOPROTEIN CD1B
CHIMERIC PROTEIN
(Homo
sapiens)		5 / 12VAL A  37
PHE A  30
PHE A  62
TRP A 146
VAL A  27
None
1.33A20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct)		5 / 12VAL A1610
PHE A1632
ILE A1545
VAL A1551
HIS A1605
None
1.22A5.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens)		5 / 12PHE A 291
ILE A 406
VAL A 409
VAL A 374
PHE A 372
None
1.28A11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		5i4e MYOSIN-14,ALPHA-ACTI
NIN A
(Homo
sapiens;
Dictyostelium
discoideum)		5 / 12PHE A 741
ILE A 785
VAL A 780
VAL A 791
PHE A 787
None
1.20A14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_B_TLFB300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		1p32 MITOCHONDRIAL MATRIX
PROTEIN, SF2P32
(Homo
sapiens)		5 / 12VAL A 183
PHE A 204
TRP A 109
VAL A 169
PHE A 168
None
1.03A18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_B_TLFB300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		1ujs ACTIN-BINDING LIM
PROTEIN HOMOLOGUE
(Homo
sapiens)		5 / 12PHE A  57
PHE A  64
ILE A  61
VAL A  56
PHE A  53
None
1.20A17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_B_TLFB300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		2iik 3-KETOACYL-COA
THIOLASE,
PEROXISOMAL
(Homo
sapiens)		5 / 12VAL A 367
PHE A 203
ILE A 195
VAL A 189
VAL A 357
None
1.34A22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_B_TLFB300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		2p5x N-ACETYLSEROTONIN
O-METHYLTRANSFERASE-
LIKE PROTEIN
(Homo
sapiens)		5 / 12PHE A  35
ILE A  85
VAL A 125
SER A  19
VAL A  37
None
None
None
PO4  A 301 (-2.3A)
None
0.91A21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_B_TLFB300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		3rpx COMPLEMENT COMPONENT
1 Q
SUBCOMPONENT-BINDING
PROTEIN
(Homo
sapiens)		5 / 12VAL A 183
PHE A 204
TRP A 109
VAL A 169
PHE A 168
None
UNX  A  60 ( 4.7A)
None
None
None
1.05A20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_B_TLFB300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		4cyf PANTETHEINASE
(Homo
sapiens)		5 / 12VAL A 224
PHE A 234
PHE A 250
VAL A 260
PHE A 262
None
CSO  A 211 ( 4.0A)
None
None
None
1.32A18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_B_TLFB300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		4dlo BRAIN-SPECIFIC
ANGIOGENESIS
INHIBITOR 3
(Homo
sapiens)		5 / 12VAL A 620
PHE A 630
ILE A 684
VAL A 685
VAL A 677
None
1.10A19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_B_TLFB300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		4elj RETINOBLASTOMA-ASSOC
IATED PROTEIN
(Homo
sapiens)		5 / 12PHE A 117
PHE A 104
ILE A 101
VAL A 128
PHE A 131
None
1.36A17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_B_TLFB300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		4jra SYNAPTIC VESICLE
GLYCOPROTEIN 2C
(Homo
sapiens)		5 / 12PHE C 512
PHE C 542
VAL C 525
PHE C 502
PHE C 547
None
1.32A15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_B_TLFB300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		4ono BETA-2-MICROGLOBULIN
/T-CELL SURFACE
GLYCOPROTEIN
CD1C/T-CELL SURFACE
GLYCOPROTEIN CD1B
CHIMERIC PROTEIN
(Homo
sapiens)		5 / 12VAL A  37
PHE A  30
PHE A  62
TRP A 146
VAL A  27
None
1.35A20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_B_TLFB300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct)		5 / 12VAL A1610
PHE A1632
ILE A1545
VAL A1551
HIS A1605
None
1.22A5.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_B_TLFB300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens)		5 / 12PHE A 291
ILE A 406
VAL A 409
VAL A 374
PHE A 372
None
1.28A11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_B_TLFB300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		5i4e MYOSIN-14,ALPHA-ACTI
NIN A
(Homo
sapiens;
Dictyostelium
discoideum)		5 / 12PHE A 741
ILE A 785
VAL A 780
VAL A 791
PHE A 787
None
1.20A14.41