POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D4S_A_TIMA401_1
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		2bu2 PYRUVATE
DEHYDROGENSAE KINASE
ISOENZYME 2
(Homo
sapiens)		5 / 12TRP A  79
VAL A  73
PHE A 146
TYR A 151
TYR A  80
None
1.30A20.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3D4S_A_TIMA401_1
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		3pbl D(3) DOPAMINE
RECEPTOR, LYSOZYME
CHIMERA
(Escherichia
virus
T4;
Homo
sapiens)		6 / 12ASP A 110
VAL A 111
SER A 192
TRP A 342
PHE A 346
TYR A 373
ETQ  A1200 (-3.5A)
ETQ  A1200 (-3.4A)
ETQ  A1200 (-3.3A)
None
ETQ  A1200 ( 4.5A)
ETQ  A1200 (-4.4A)
0.71A56.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3D4S_A_TIMA401_1
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		3pbl D(3) DOPAMINE
RECEPTOR, LYSOZYME
CHIMERA
(Escherichia
virus
T4;
Homo
sapiens)		6 / 12ASP A 110
VAL A 111
SER A 192
TRP A 342
TYR A 365
TYR A 373
ETQ  A1200 (-3.5A)
ETQ  A1200 (-3.4A)
ETQ  A1200 (-3.3A)
None
None
ETQ  A1200 (-4.4A)
1.03A56.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3D4S_A_TIMA401_1
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		3pds FUSION PROTEIN
BETA-2 ADRENERGIC
RECEPTOR/LYSOZYME
(Escherichia
virus
T4;
Homo
sapiens)		5 / 12TRP A 109
ASP A 113
VAL A 117
SER A 204
TYR A 316
None
ERC  A1201 (-3.7A)
None
ERC  A1201 ( 4.1A)
None
1.30A99.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3D4S_A_TIMA401_1
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		3pds FUSION PROTEIN
BETA-2 ADRENERGIC
RECEPTOR/LYSOZYME
(Escherichia
virus
T4;
Homo
sapiens)		8 / 12TRP A 109
THR A 110
ASP A 113
VAL A 114
SER A 207
TYR A 308
ASN A 312
TYR A 316
None
ERC  A1201 ( 4.6A)
ERC  A1201 (-3.7A)
ERC  A1201 (-3.8A)
ERC  A1201 (-2.7A)
None
ERC  A1201 (-3.0A)
None
1.20A99.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3D4S_A_TIMA401_1
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		3pds FUSION PROTEIN
BETA-2 ADRENERGIC
RECEPTOR/LYSOZYME
(Escherichia
virus
T4;
Homo
sapiens)		12 / 12TRP A 109
THR A 110
ASP A 113
VAL A 114
VAL A 117
SER A 203
TRP A 286
PHE A 290
ASN A 293
TYR A 308
ASN A 312
TYR A 316
None
ERC  A1201 ( 4.6A)
ERC  A1201 (-3.7A)
ERC  A1201 (-3.8A)
None
ERC  A1201 (-2.8A)
None
ERC  A1201 (-4.8A)
ERC  A1201 (-3.5A)
None
ERC  A1201 (-3.0A)
None
0.68A99.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3D4S_A_TIMA401_1
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		3pds FUSION PROTEIN
BETA-2 ADRENERGIC
RECEPTOR/LYSOZYME
(Escherichia
virus
T4;
Homo
sapiens)		5 / 12VAL A 114
ASN A 293
TYR A 308
ASN A 312
TYR A 316
ERC  A1201 (-3.8A)
ERC  A1201 (-3.5A)
None
ERC  A1201 (-3.0A)
None
1.41A99.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3D4S_A_TIMA401_1
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		3rze HISTAMINE H1
RECEPTOR, LYSOZYME
CHIMERA
(Escherichia
virus
T4;
Homo
sapiens)		5 / 12TRP A 103
ASP A 107
TRP A 428
PHE A 432
TYR A 458
None
5EH  A1200 ( 2.6A)
5EH  A1200 ( 3.4A)
5EH  A1200 ( 4.3A)
5EH  A1200 ( 4.4A)
0.59A53.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3D4S_A_TIMA401_1
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		4gbr BETA-2 ADRENERGIC
RECEPTOR
(Homo
sapiens)		8 / 12TRP A 109
THR A 110
ASP A 113
VAL A 114
SER A 207
PHE A 262
ASN A 284
TYR A 288
None
CAU  A 500 ( 4.0A)
CAU  A 500 (-3.0A)
CAU  A 500 (-3.5A)
CAU  A 500 (-4.1A)
CAU  A 500 (-4.6A)
CAU  A 500 (-3.3A)
CAU  A 500 (-4.6A)
1.17A57.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3D4S_A_TIMA401_1
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		4gbr BETA-2 ADRENERGIC
RECEPTOR
(Homo
sapiens)		12 / 12TRP A 109
THR A 110
ASP A 113
VAL A 114
VAL A 117
SER A 203
TRP A 258
PHE A 262
ASN A 265
TYR A 280
ASN A 284
TYR A 288
None
CAU  A 500 ( 4.0A)
CAU  A 500 (-3.0A)
CAU  A 500 (-3.5A)
CAU  A 500 (-4.2A)
CAU  A 500 (-3.3A)
None
CAU  A 500 (-4.6A)
CAU  A 500 (-3.4A)
None
CAU  A 500 (-3.3A)
CAU  A 500 (-4.6A)
0.51A57.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3D4S_A_TIMA401_1
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		4ib4 CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens)		7 / 12TRP A 131
ASP A 135
VAL A 136
TRP A 337
PHE A 341
ASN A 344
TYR A 370
None
ERM  A2001 (-3.2A)
ERM  A2001 (-3.8A)
None
None
ERM  A2001 (-4.3A)
ERM  A2001 ( 4.8A)
0.58A31.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3D4S_A_TIMA401_1
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		4lde LYSOZYME, BETA-2
ADRENERGIC RECEPTOR
(Escherichia
virus
T4;
Homo
sapiens)		11 / 12TRP A1109
THR A1110
ASP A1113
VAL A1114
VAL A1117
SER A1203
TRP A1286
PHE A1290
TYR A1308
ASN A1312
TYR A1316
None
P0G  A1401 ( 3.9A)
P0G  A1401 (-2.9A)
P0G  A1401 (-3.7A)
P0G  A1401 ( 4.4A)
P0G  A1401 (-2.9A)
None
P0G  A1401 ( 4.9A)
None
P0G  A1401 (-2.9A)
None
0.76A49.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3D4S_A_TIMA401_1
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		4lde LYSOZYME, BETA-2
ADRENERGIC RECEPTOR
(Escherichia
virus
T4;
Homo
sapiens)		11 / 12TRP A1109
THR A1110
ASP A1113
VAL A1114
VAL A1117
TRP A1286
PHE A1290
ASN A1293
TYR A1308
ASN A1312
TYR A1316
None
P0G  A1401 ( 3.9A)
P0G  A1401 (-2.9A)
P0G  A1401 (-3.7A)
P0G  A1401 ( 4.4A)
None
P0G  A1401 ( 4.9A)
P0G  A1401 (-3.0A)
None
P0G  A1401 (-2.9A)
None
0.58A49.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D4S_A_TIMA401_1
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		5v54 5-HYDROXYTRYPTAMINE
RECEPTOR 1B,OB-1
FUSED 5-HT1B
RECEPTOR,5-HYDROXYTR
YPTAMINE RECEPTOR 1B
(Homo
sapiens;
Spodoptera
frugiperda)		6 / 12TRP A 125
ASP A 129
SER A 212
TRP A 327
PHE A 331
TYR A 359
None
89F  A1201 (-3.3A)
89F  A1201 ( 3.8A)
89F  A1201 (-3.6A)
89F  A1201 (-4.6A)
None
0.78A11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D4S_A_TIMA401_1
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		5wiv D(4) DOPAMINE
RECEPTOR, SOLUBLE
CYTOCHROME B562
CHIMERA
(Escherichia
coli;
Homo
sapiens)		6 / 12ASP A 115
VAL A 116
SER A 196
TRP A 407
PHE A 411
TYR A 438
AQD  A1201 (-3.3A)
AQD  A1201 ( 3.9A)
AQD  A1201 (-2.8A)
None
AQD  A1201 (-4.6A)
None
0.74A27.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D4S_A_TIMA401_1
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		5yjh PERIOSTIN
(Homo
sapiens)		5 / 12THR A 270
VAL A 357
VAL A 352
TYR A 199
ASN A 197
None
None
None
None
MG  A 728 (-3.6A)
1.27A9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D4S_A_TIMA401_1
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens)		5 / 12TRP A 130
ASP A 134
SER A 219
ASN A 331
TYR A 358
None
E2J  A1201 (-3.0A)
E2J  A1201 (-3.2A)
None
None
1.32A9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D4S_A_TIMA401_1
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens)		6 / 12TRP A 130
ASP A 134
TRP A 324
PHE A 328
ASN A 331
TYR A 358
None
E2J  A1201 (-3.0A)
E2J  A1201 ( 3.7A)
E2J  A1201 (-4.4A)
None
None
0.57A9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D4S_A_TIMA401_1
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens)		6 / 12TRP A 130
ASP A 134
VAL A 135
TRP A 324
PHE A 328
TYR A 358
None
E2J  A1201 (-3.0A)
E2J  A1201 (-3.8A)
E2J  A1201 ( 3.7A)
E2J  A1201 (-4.4A)
None
0.73A9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D4S_A_TIMA401_1
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		6cm4 D(2) DOPAMINE
RECEPTOR, ENDOLYSIN
CHIMERA
(Escherichia
virus
T4;
Homo
sapiens)		5 / 12ASP A 114
VAL A 115
TRP A 386
PHE A 390
TYR A 416
8NU  A2001 ( 3.0A)
8NU  A2001 ( 3.5A)
8NU  A2001 ( 3.8A)
8NU  A2001 ( 4.8A)
8NU  A2001 ( 4.9A)
0.61A11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D4S_A_TIMA401_1
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		6g79 5-HYDROXYTRYPTAMINE
RECEPTOR 1B
(Homo
sapiens)		6 / 12TRP S 125
ASP S 129
SER S 212
TRP S 327
PHE S 331
TYR S 359
None
EP5  S 401 (-3.3A)
EP5  S 401 (-3.3A)
None
EP5  S 401 (-4.7A)
EP5  S 401 ( 4.9A)
0.58A9.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D4S_A_TIMA401_2
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		1kwm PROCARBOXYPEPTIDASE
B
(Homo
sapiens)		3 / 3THR A  32
SER A  31
PHE A  54
None
0.87A20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D4S_A_TIMA401_2
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		1n1a FKBP52
(Homo
sapiens)		3 / 3THR A  58
SER A  69
PHE A 135
None
0.70A14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D4S_A_TIMA401_2
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		1qrp PEPSIN 3A
(Homo
sapiens)		3 / 3THR E 198
SER E 196
PHE E 305
None
0.85A20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D4S_A_TIMA401_2
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		1rxt GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE 1
(Homo
sapiens)		3 / 3THR A 313
SER A 328
PHE A 393
None
0.80A19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D4S_A_TIMA401_2
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		1x1g PLECKSTRIN 2
(Homo
sapiens)		3 / 3THR A  96
SER A  69
PHE A  92
None
0.88A14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D4S_A_TIMA401_2
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		1y4j SULFATASE MODIFYING
FACTOR 2
(Homo
sapiens)		3 / 3THR A 238
SER A 240
PHE A  62
None
0.89A22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D4S_A_TIMA401_2
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		2crw ADP-RIBOSYLATION
FACTOR
GTPASE-ACTIVATING
PROTEIN 3
(Homo
sapiens)		3 / 3THR A  46
SER A  67
PHE A  33
None
0.77A16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D4S_A_TIMA401_2
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		2ebm RWD
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens)		3 / 3THR A  62
SER A  39
PHE A  77
None
0.90A13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D4S_A_TIMA401_2
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		2i1y RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE
(Homo
sapiens)		3 / 3THR A 884
SER A 883
PHE A 849
None
0.90A20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D4S_A_TIMA401_2
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		2kbo DNA DC->DU-EDITING
ENZYME APOBEC-3G
(Homo
sapiens)		3 / 3THR A 121
SER A  96
PHE A  72
None
0.72A16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D4S_A_TIMA401_2
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		3dyt SORTING NEXIN-9
(Homo
sapiens)		3 / 3THR A 275
SER A 282
PHE A 353
None
0.88A19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D4S_A_TIMA401_2
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		3go1 FAB 268-D, LIGHT
CHAIN
(Homo
sapiens)		3 / 3THR L 114
SER L 137
PHE L 118
None
0.81A16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D4S_A_TIMA401_2
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		3o4r DEHYDROGENASE/REDUCT
ASE SDR FAMILY
MEMBER 4
(Homo
sapiens)		3 / 3THR A  38
SER A 115
PHE A 219
None
None
NAP  A 601 (-4.1A)
0.88A19.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3D4S_A_TIMA401_2
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		3pbl D(3) DOPAMINE
RECEPTOR, LYSOZYME
CHIMERA
(Escherichia
virus
T4;
Homo
sapiens)		3 / 3THR A 115
SER A 196
PHE A 345
None
ETQ  A1200 ( 4.6A)
ETQ  A1200 (-4.4A)
0.75A56.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D4S_A_TIMA401_2
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		3pkj NAD-DEPENDENT
DEACETYLASE
SIRTUIN-6
(Homo
sapiens)		3 / 3THR A  49
SER A 110
PHE A  62
None
None
A2N  A1000 (-3.8A)
0.87A18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D4S_A_TIMA401_2
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		3zd2 COMPLEMENT FACTOR
H-RELATED PROTEIN 1
(Homo
sapiens)		3 / 3THR A 118
SER A 117
PHE A  71
None
0.88A13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D4S_A_TIMA401_2
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		3zg6 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-6
(Homo
sapiens)		3 / 3THR A  49
SER A 110
PHE A  62
None
None
APR  A1296 (-3.6A)
0.88A19.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3D4S_A_TIMA401_2
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		4gbr BETA-2 ADRENERGIC
RECEPTOR
(Homo
sapiens)		3 / 3THR A 118
SER A 207
PHE A 261
CAU  A 500 ( 4.7A)
CAU  A 500 (-4.1A)
CAU  A 500 (-4.2A)
0.15A57.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D4S_A_TIMA401_2
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
(Homo
sapiens)		3 / 3THR A  58
SER A  69
PHE A 135
None
0.80A19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D4S_A_TIMA401_2
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		4qci ANTI-PDGF-BB
ANTIBODY - LIGHT
CHAIN
(Homo
sapiens)		3 / 3THR A 112
SER A 135
PHE A 116
None
0.70A18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D4S_A_TIMA401_2
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		4y18 BREAST CANCER TYPE 1
SUSCEPTIBILITY
PROTEIN
(Homo
sapiens)		3 / 3THR A1675
SER A1651
PHE A1662
None
0.78A18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D4S_A_TIMA401_2
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		4ydj LIGHT CHAIN OF
ANTIBODY 44-VRC13.01
(Homo
sapiens)		3 / 3THR L 114
SER L 137
PHE L 118
None
0.81A17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D4S_A_TIMA401_2
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		5er7 GAP JUNCTION BETA-2
PROTEIN
(Homo
sapiens)		3 / 3THR B 189
SER B 162
PHE B  69
None
0.67A20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D4S_A_TIMA401_2
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		5f89 CAP248-2B LIGHT
CHAIN
(Homo
sapiens)		3 / 3THR L 115
SER L 138
PHE L 119
None
0.80A18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D4S_A_TIMA401_2
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		5f8p ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE FTO
(Homo
sapiens)		3 / 3THR A 202
SER A 319
PHE A 296
None
0.85A21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D4S_A_TIMA401_2
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		5ggg PROTEIN
O-LINKED-MANNOSE
BETA-1,2-N-ACETYLGLU
COSAMINYLTRANSFERASE
1
(Homo
sapiens)		3 / 3THR A 285
SER A 277
PHE A 268
None
0.82A22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D4S_A_TIMA401_2
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		5neu INTEGRIN ALPHA-V
(Homo
sapiens)		3 / 3THR A  64
SER A  63
PHE A  35
None
0.79A22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D4S_A_TIMA401_2
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		5wiv D(4) DOPAMINE
RECEPTOR, SOLUBLE
CYTOCHROME B562
CHIMERA
(Escherichia
coli;
Homo
sapiens)		3 / 3THR A 120
SER A 200
PHE A 410
AQD  A1201 (-4.4A)
AQD  A1201 (-3.6A)
AQD  A1201 (-4.7A)
0.64A27.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D4S_A_TIMA401_2
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		5zal ENDORIBONUCLEASE
DICER
(Homo
sapiens)		3 / 3THR A 348
SER A 299
PHE A 280
None
0.84A12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D4S_A_TIMA401_2
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		6cm4 D(2) DOPAMINE
RECEPTOR, ENDOLYSIN
CHIMERA
(Escherichia
virus
T4;
Homo
sapiens)		3 / 3THR A 119
SER A 197
PHE A 389
8NU  A2001 ( 4.4A)
8NU  A2001 ( 3.6A)
8NU  A2001 ( 4.5A)
0.56A11.24