POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1WSV_A_THHA3001_0
(AMINOMETHYLTRANSFERA
SE)		1wsv AMINOMETHYLTRANSFERA
SE
(Homo
sapiens)		12 / 12MET A  56
THR A  87
LEU A  88
ILE A 103
VAL A 115
ASN A 117
PHE A 176
MET A 177
TYR A 197
ARG A 233
LEU A 242
TRP A 262
MET  A  56 (-0.0A)
THR  A  87 ( 0.8A)
LEU  A  88 (-0.6A)
ILE  A 103 (-0.7A)
VAL  A 115 (-0.6A)
ASN  A 117 (-0.6A)
PHE  A 176 (-1.3A)
MET  A 177 (-0.0A)
TYR  A 197 (-1.3A)
ARG  A 233 (-0.6A)
LEU  A 242 (-0.6A)
TRP  A 262 ( 0.5A)
0.02A100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_0
(AMINOMETHYLTRANSFERA
SE)		1xcr HYPOTHETICAL PROTEIN
PTD012
(Homo
sapiens)		5 / 12ILE A 171
VAL A  35
PHE A 253
MET A 203
LEU A  24
None
1.28A22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_0
(AMINOMETHYLTRANSFERA
SE)		2zu6 EUKARYOTIC
INITIATION FACTOR
4A-I
(Homo
sapiens)		5 / 12LEU A 263
ILE A 345
VAL A 344
MET A 375
LEU A 288
None
1.20A22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_0
(AMINOMETHYLTRANSFERA
SE)		3e9k KYNURENINASE
(Homo
sapiens)		5 / 12THR A 455
LEU A 458
ILE A 457
ASN A 411
PHE A 450
None
1.28A22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_0
(AMINOMETHYLTRANSFERA
SE)		3rjo ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens)		5 / 12MET A 604
THR A 534
LEU A 532
ILE A 533
VAL A 602
None
1.29A21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_0
(AMINOMETHYLTRANSFERA
SE)		3vn9 DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 6
(Homo
sapiens)		5 / 12LEU A 155
ILE A 158
PHE A 327
TYR A 140
LEU A 253
None
1.08A23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_0
(AMINOMETHYLTRANSFERA
SE)		3wbg FATTY ACID-BINDING
PROTEIN, HEART
(Homo
sapiens)		5 / 12THR A  50
LEU A  51
VAL A   1
PHE A  70
LEU A 104
None
0.91A18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_0
(AMINOMETHYLTRANSFERA
SE)		5exr DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT
(Homo
sapiens)		5 / 12LEU C1212
ILE C1216
VAL C1220
PHE C1133
ARG C1115
None
1.18A15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_0
(AMINOMETHYLTRANSFERA
SE)		5htk 6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
SPHOSPHATASE 2
(Homo
sapiens)		5 / 12THR A 424
LEU A 423
ILE A 252
VAL A 386
LEU A 399
None
1.31A21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_0
(AMINOMETHYLTRANSFERA
SE)		6en4 SPLICING FACTOR 3B
SUBUNIT 3
(Homo
sapiens)		5 / 12THR A 761
LEU A 762
ILE A 757
PHE A 478
LEU A 485
None
1.27Aundetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1WSV_A_THHA3001_1
(AMINOMETHYLTRANSFERA
SE)		1wsv AMINOMETHYLTRANSFERA
SE
(Homo
sapiens)		3 / 3ASP A 101
GLU A 204
TYR A 371
ASP  A 101 (-0.6A)
GLU  A 204 (-0.5A)
TYR  A 371 (-1.3A)
0.02A100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_1
(AMINOMETHYLTRANSFERA
SE)		2jdx PROTEIN
(L-ARGININE:GLYCINE
AMIDINOTRANSFERASE)
(Homo
sapiens)		3 / 3ASP A 298
GLU A 101
TYR A 227
None
0.85A19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_1
(AMINOMETHYLTRANSFERA
SE)		2oo4 NEUROGENIC LOCUS
NOTCH HOMOLOG
PROTEIN 2
(Homo
sapiens)		3 / 3ASP A1454
GLU A1617
TYR A1592
 CA  A5001 (-3.4A)
None
None
0.45A21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_1
(AMINOMETHYLTRANSFERA
SE)		2xij METHYLMALONYL-COA
MUTASE,
MITOCHONDRIAL
(Homo
sapiens)		3 / 3ASP A 139
GLU A 117
TYR A 123
None
EDO  A1753 (-2.8A)
None
0.76A21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_1
(AMINOMETHYLTRANSFERA
SE)		2y96 DUAL SPECIFICITY
PHOSPHATASE DUPD1
(Homo
sapiens)		3 / 3ASP A 139
GLU A  57
TYR A 161
None
0.78A20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_1
(AMINOMETHYLTRANSFERA
SE)		3ojy COMPLEMENT COMPONENT
C8 BETA CHAIN
(Homo
sapiens)		3 / 3ASP B 244
GLU B 192
TYR B 224
None
0.80A21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_1
(AMINOMETHYLTRANSFERA
SE)		4zdl O-PHOSPHOSERYL-TRNA(
SEC) SELENIUM
TRANSFERASE
(Homo
sapiens)		3 / 3ASP A 201
GLU A 211
TYR A 245
None
0.79A23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_1
(AMINOMETHYLTRANSFERA
SE)		5f0l VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 26A
(Homo
sapiens)		3 / 3ASP B 142
GLU B  94
TYR B 107
None
EDO  B 409 (-3.3A)
None
0.79A23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_1
(AMINOMETHYLTRANSFERA
SE)		5ool 39S RIBOSOMAL
PROTEIN L37,
MITOCHONDRIAL
39S RIBOSOMAL
PROTEIN L41,
MITOCHONDRIAL
39S RIBOSOMAL
PROTEIN L24,
MITOCHONDRIAL
(Homo
sapiens;
Homo
sapiens;
Homo
sapiens)		3 / 3ASP 5  84
GLU 9  55
TYR V 210
 C  A1707 ( 4.6A)
None
None
0.75A21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_1
(AMINOMETHYLTRANSFERA
SE)		5t0h 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT 2
(Homo
sapiens)		3 / 3ASP f 393
GLU f 468
TYR f 441
None
0.86A19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_1
(AMINOMETHYLTRANSFERA
SE)		5u3n DH511.12P FAB HEAVY
CHAIN
DH511.12P FAB LIGHT
CHAIN
(Homo
sapiens;
Homo
sapiens)		3 / 3ASP H  53
GLU H  96
TYR L  96
None
0.77A22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_1
(AMINOMETHYLTRANSFERA
SE)		5y2z LEUCINE-RICH
GLIOMA-INACTIVATED
PROTEIN 1
(Homo
sapiens)		3 / 3ASP B 240
GLU B 383
TYR B 433
None
0.83Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_1
(AMINOMETHYLTRANSFERA
SE)		5y31 LEUCINE-RICH
GLIOMA-INACTIVATED
PROTEIN 1
(Homo
sapiens)		3 / 3ASP B 240
GLU B 383
TYR B 433
None
0.84Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_1
(AMINOMETHYLTRANSFERA
SE)		6eoq DIPEPTIDYL PEPTIDASE
9
(Homo
sapiens)		3 / 3ASP A 251
GLU A 690
TYR A 644
None
0.81Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_1
(AMINOMETHYLTRANSFERA
SE)		6f9n CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
SUBUNIT 1
PRE-MRNA 3' END
PROCESSING PROTEIN
WDR33
(Homo
sapiens;
Homo
sapiens)		3 / 3ASP B 409
GLU A1058
TYR A1066
None
0.75Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_B_THHB4001_0
(AMINOMETHYLTRANSFERA
SE)		1cmo POLYOMAVIRUS
ENHANCER BINDING
PROTEIN 2
(Homo
sapiens)		5 / 12MET A 124
THR A 161
ILE A 150
VAL A 103
LEU A  71
None
1.33A20.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1WSV_B_THHB4001_0
(AMINOMETHYLTRANSFERA
SE)		1wsv AMINOMETHYLTRANSFERA
SE
(Homo
sapiens)		11 / 12MET A  56
THR A  87
LEU A  88
ILE A 103
VAL A 115
ASN A 117
PHE A 176
MET A 177
TYR A 197
LEU A 242
TRP A 262
MET  A  56 (-0.0A)
THR  A  87 ( 0.8A)
LEU  A  88 (-0.6A)
ILE  A 103 (-0.7A)
VAL  A 115 (-0.6A)
ASN  A 117 (-0.6A)
PHE  A 176 (-1.3A)
MET  A 177 (-0.0A)
TYR  A 197 (-1.3A)
LEU  A 242 (-0.6A)
TRP  A 262 ( 0.5A)
0.19A100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_B_THHB4001_0
(AMINOMETHYLTRANSFERA
SE)		2ado MEDIATOR OF DNA
DAMAGE CHECKPOINT
PROTEIN 1
(Homo
sapiens)		5 / 12LEU A2065
ILE A2017
VAL A1935
CYH A2020
TYR A2025
None
1.35A22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_B_THHB4001_0
(AMINOMETHYLTRANSFERA
SE)		2zu6 EUKARYOTIC
INITIATION FACTOR
4A-I
(Homo
sapiens)		5 / 12LEU A 263
ILE A 345
VAL A 344
MET A 375
LEU A 288
None
1.18A22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_B_THHB4001_0
(AMINOMETHYLTRANSFERA
SE)		3e9k KYNURENINASE
(Homo
sapiens)		5 / 12THR A 455
LEU A 458
ILE A 457
ASN A 411
PHE A 450
None
1.35A22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_B_THHB4001_0
(AMINOMETHYLTRANSFERA
SE)		3wbg FATTY ACID-BINDING
PROTEIN, HEART
(Homo
sapiens)		5 / 12THR A  50
LEU A  51
VAL A   1
PHE A  70
LEU A 104
None
0.93A18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_B_THHB4001_0
(AMINOMETHYLTRANSFERA
SE)		6en4 SPLICING FACTOR 3B
SUBUNIT 3
(Homo
sapiens)		5 / 12THR A 761
LEU A 762
ILE A 757
PHE A 478
LEU A 485
None
1.27Aundetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1WSV_B_THHB4001_1
(AMINOMETHYLTRANSFERA
SE)		1wsv AMINOMETHYLTRANSFERA
SE
(Homo
sapiens)		4 / 4ASP A 101
GLU A 204
ARG A 233
TYR A 371
ASP  A 101 (-0.6A)
GLU  A 204 (-0.5A)
ARG  A 233 (-0.6A)
TYR  A 371 (-1.3A)
0.23A100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_B_THHB4001_1
(AMINOMETHYLTRANSFERA
SE)		3m7p FN1 PROTEIN
(Homo
sapiens)		4 / 4ASP A 381
GLU A 377
ARG A 592
TYR A 392
 ZN  A 956 ( 4.4A)
ZN  A 955 ( 4.3A)
None
None
1.29A20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_B_THHB4001_1
(AMINOMETHYLTRANSFERA
SE)		3ojy COMPLEMENT COMPONENT
C8 ALPHA CHAIN
COMPLEMENT COMPONENT
C8 BETA CHAIN
(Homo
sapiens;
Homo
sapiens)		4 / 4ASP A  90
GLU A 108
ARG A 177
TYR B 261
 CA  A 555 (-3.4A)
None
None
None
1.29A21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_A_THHA401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		1fsu N-ACETYLGALACTOSAMIN
E-4-SULFATASE
(Homo
sapiens)		5 / 12ILE A 220
LEU A 222
LEU A 234
VAL A 143
THR A 216
None
None
None
None
NAG  A 600 ( 4.0A)
1.12A17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_A_THHA401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		1ozn RETICULON 4 RECEPTOR
(Homo
sapiens)		5 / 12LEU A 110
LEU A 129
PRO A  56
THR A  40
THR A  84
None
1.19A23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_A_THHA401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		1p1a UV EXCISION REPAIR
PROTEIN RAD23
HOMOLOG B
(Homo
sapiens)		5 / 12ILE A  55
LEU A  56
PRO A  43
THR A  78
VAL A  26
None
1.25A18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_A_THHA401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		1zlr COAGULATION FACTOR
XI
(Homo
sapiens)		5 / 12LEU A 106
LEU A 108
THR A 139
VAL A  67
PRO A 198
None
1.17A22.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DCJ_A_THHA401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		1zly PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE
(Homo
sapiens)		5 / 12MET A  89
ILE A  91
LEU A  92
ASN A 106
VAL A 139
None
DQB  A1301 (-3.5A)
DQB  A1301 (-4.4A)
DQB  A1301 (-3.6A)
DQB  A1301 (-4.3A)
0.53A37.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_A_THHA401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		2h45 FIBRONECTIN
(Homo
sapiens)		5 / 12LEU A  52
LEU A  54
ASN A  62
THR A  95
VAL A  61
None
1.16A21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_A_THHA401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		2ha1 FIBRONECTIN
(Homo
sapiens)		5 / 12LEU A 158
LEU A 160
ASN A 168
THR A 201
VAL A 167
None
1.21A21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_A_THHA401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		2qtz METHIONINE SYNTHASE
REDUCTASE
(Homo
sapiens)		5 / 12LEU A 250
LEU A 343
PRO A 380
PRO A 437
PRO A 436
None
1.24A17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_A_THHA401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		4bn2 KINESIN-LIKE PROTEIN
KIF15
(Homo
sapiens)		5 / 12ILE A 153
LEU A 163
LEU A 164
THR A  90
THR A 227
None
1.21A22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_A_THHA401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		4xii CHOLINESTERASE
(Homo
sapiens)		5 / 12LEU A 168
LEU A 206
THR A 243
THR A 293
PRO A 163
None
1.25A18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_A_THHA401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		5eod COAGULATION FACTOR
XI
(Homo
sapiens)		5 / 12LEU A 466
LEU A 468
THR A 499
VAL A 426
PRO A 560
None
1.25A16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_A_THHA401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		5gu6 ENDOPLASMIC
RETICULUM RESIDENT
PROTEIN 44
(Homo
sapiens)		5 / 12ILE A  69
LEU A   5
LEU A  14
ASN A  23
VAL A  22
None
1.23A17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_A_THHA401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		5hbt ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA 1
(Homo
sapiens)		5 / 12MET B 171
LEU B  37
LEU B  35
ASN B  53
VAL B  54
None
1.26A23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_A_THHA401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		6b5i RETINAL
DEHYDROGENASE 2
(Homo
sapiens)		5 / 12LEU A 239
PRO A 176
VAL A 208
PRO A 233
PRO A 232
None
1.27Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_A_THHA401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		6eot DIPEPTIDYL PEPTIDASE
8
(Homo
sapiens)		5 / 12MET A 763
ILE A 751
LEU A 734
ASN A 704
PRO A 672
None
1.24Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_B_THHB401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		1fnf FIBRONECTIN
(Homo
sapiens)		4 / 8ILE A1232
LEU A1149
THR A1157
VAL A1162
None
0.83A23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_B_THHB401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		1h6f T-BOX TRANSCRIPTION
FACTOR TBX3
(Homo
sapiens)		4 / 8SER A 246
ILE A 240
LEU A 152
VAL A 235
None
0.80A20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_B_THHB401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		1vig VIGILIN
(Homo
sapiens)		4 / 8SER A  76
ILE A  32
LEU A  24
GLY A  29
None
0.87A14.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DCJ_B_THHB401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		1zly PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE
(Homo
sapiens)		4 / 8ILE A  91
LEU A  92
ASN A 106
VAL A 139
DQB  A1301 (-3.5A)
DQB  A1301 (-4.4A)
DQB  A1301 (-3.6A)
DQB  A1301 (-4.3A)
0.57A37.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_B_THHB401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		2akz GAMMA ENOLASE
(Homo
sapiens)		4 / 8LEU A 387
THR A 394
VAL A 366
GLY A 390
None
0.73A22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_B_THHB401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		2b5m DAMAGE-SPECIFIC DNA
BINDING PROTEIN 1
(Homo
sapiens)		5 / 8LEU A1000
ASN A1005
THR A 377
VAL A1004
GLY A1038
None
1.33A11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_B_THHB401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		2bp1 AFLATOXIN B1
ALDEHYDE REDUCTASE
MEMBER 2
(Homo
sapiens)		4 / 8LEU A  92
THR A 105
VAL A 101
GLY A  95
None
0.82A21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_B_THHB401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		2clp AFLATOXIN B1
ALDEHYDE REDUCTASE
MEMBER 3
(Homo
sapiens)		4 / 8LEU A  92
THR A 105
VAL A 101
GLY A  95
None
0.71A20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_B_THHB401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		2iik 3-KETOACYL-COA
THIOLASE,
PEROXISOMAL
(Homo
sapiens)		4 / 8ILE A 389
LEU A 392
VAL A  40
GLY A  43
None
0.76A23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_B_THHB401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		2x4f MYOSIN LIGHT CHAIN
KINASE FAMILY MEMBER
4
(Homo
sapiens)		4 / 8SER A 301
ILE A 315
LEU A 342
VAL A 291
None
0.83A20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_B_THHB401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		2xsx BETA-ENOLASE
(Homo
sapiens)		4 / 8LEU A 388
THR A 395
VAL A 367
GLY A 391
None
0.67A19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_B_THHB401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		3bqr DEATH-ASSOCIATED
PROTEIN KINASE 3
(Homo
sapiens)		4 / 8SER A 215
ILE A 229
LEU A 256
VAL A 205
None
0.70A21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_B_THHB401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		3if8 PROTEIN ZWILCH
HOMOLOG
(Homo
sapiens)		4 / 8ILE A 110
LEU A 109
THR A 148
VAL A  64
None
0.79A22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_B_THHB401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		3ow8 WD REPEAT-CONTAINING
PROTEIN 61
(Homo
sapiens)		4 / 8SER A 165
LEU A 163
ASN A 173
GLY A 180
None
0.85A23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_B_THHB401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		3rjo ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens)		4 / 8LEU A 710
LEU A 707
THR A 629
VAL A 673
None
0.85A20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_B_THHB401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		4f92 U5 SMALL NUCLEAR
RIBONUCLEOPROTEIN
200 KDA HELICASE
(Homo
sapiens)		4 / 8SER B 420
LEU B 887
LEU B 655
THR B 831
None
0.85A9.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_B_THHB401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		4fc7 PEROXISOMAL
2,4-DIENOYL-COA
REDUCTASE
(Homo
sapiens)		4 / 8SER A 145
LEU A 192
THR A 164
GLY A 262
None
0.86A26.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_B_THHB401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		5fqd DNA DAMAGE-BINDING
PROTEIN 1
(Homo
sapiens)		5 / 8LEU A1000
ASN A1005
THR A 377
VAL A1004
GLY A1038
None
1.38A14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_B_THHB401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		5hz5 FATTY ACID-BINDING
PROTEIN, EPIDERMAL
(Homo
sapiens)		4 / 8LEU A  52
LEU A  69
VAL A   4
GLY A  49
None
0.86A22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		3kcx HYPOXIA-INDUCIBLE
FACTOR 1-ALPHA
INHIBITOR
(Homo
sapiens)		5 / 12GLY A 190
SER A 283
ASN A 194
ARG A  33
ILE A 289
None
1.27A22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		3lmk METABOTROPIC
GLUTAMATE RECEPTOR 5
(Homo
sapiens)		5 / 12GLU A 279
GLY A 280
ASP A 305
VAL A 192
GLY A 150
None
None
GLU  A 506 (-2.7A)
None
None
1.11A20.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K13_A_THHA642_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		4ccz METHIONINE SYNTHASE
(Homo
sapiens)		8 / 12ASN A 379
GLY A 382
ASP A 414
VAL A 496
GLY A 576
ASN A 579
PHE A 582
ARG A 585
THG  A1652 (-4.6A)
THG  A1652 (-3.8A)
None
None
THG  A1652 (-3.6A)
THG  A1652 (-3.1A)
THG  A1652 (-4.5A)
THG  A1652 (-3.3A)
1.45A30.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K13_A_THHA642_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		4ccz METHIONINE SYNTHASE
(Homo
sapiens)		5 / 12ASN A 379
GLY A 382
ASP A 449
GLY A 375
ARG A 591
THG  A1652 (-4.6A)
THG  A1652 (-3.8A)
THG  A1652 (-3.4A)
None
THG  A1652 (-3.0A)
1.26A30.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K13_A_THHA642_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		4ccz METHIONINE SYNTHASE
(Homo
sapiens)		11 / 12GLU A 376
ASN A 379
GLY A 382
ASP A 449
VAL A 496
GLY A 576
SER A 578
ASN A 579
PHE A 582
ARG A 585
ILE A 611
THG  A1652 (-3.5A)
THG  A1652 (-4.6A)
THG  A1652 (-3.8A)
THG  A1652 (-3.4A)
None
THG  A1652 (-3.6A)
THG  A1652 (-4.2A)
THG  A1652 (-3.1A)
THG  A1652 (-4.5A)
THG  A1652 (-3.3A)
THG  A1652 (-4.2A)
0.38A30.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		4fc7 PEROXISOMAL
2,4-DIENOYL-COA
REDUCTASE
(Homo
sapiens)		5 / 12GLY A 213
VAL A 249
GLY A  41
SER A  38
ILE A  40
None
None
None
NAP  A 401 (-2.7A)
NAP  A 401 (-4.0A)
1.20A23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		4raf PROTEIN PHOSPHATASE
1A
(Homo
sapiens)		5 / 12GLU A  35
ASN A 283
ASP A  60
VAL A 193
PHE A   4
None
None
MN  A 401 (-2.5A)
None
None
1.29A23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens)		5 / 12GLY A 218
ASP A 187
GLY A 212
SER A 215
ASN A 228
None
1.26A21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		5vni PROTEIN TRANSPORT
PROTEIN SEC23A
(Homo
sapiens)		5 / 12GLY A 374
ASP A 598
VAL A 301
GLY A 292
PHE A 377
None
1.21A18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		1xwi SKD1 PROTEIN
(Homo
sapiens)		3 / 3ASN A 279
ASP A 234
ARG A 346
SO4  A 601 ( 3.5A)
SO4  A 601 ( 4.4A)
None
0.88A24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		2qfa BOREALIN
INNER CENTROMERE
PROTEIN
(Homo
sapiens;
Homo
sapiens)		3 / 3ASN C  25
ASP B  42
ARG B  30
None
0.70A12.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K13_A_THHA642_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		4ccz METHIONINE SYNTHASE
(Homo
sapiens)		3 / 3ASN A 470
ASP A 537
ARG A 585
THG  A1652 (-3.2A)
THG  A1652 (-3.4A)
THG  A1652 (-3.3A)
0.64A30.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K13_A_THHA642_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		4ccz METHIONINE SYNTHASE
(Homo
sapiens)		3 / 3ASN A 470
ASP A 537
ARG A 591
THG  A1652 (-3.2A)
THG  A1652 (-3.4A)
THG  A1652 (-3.0A)
0.19A30.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		4fdj N-ACETYLGALACTOSAMIN
E-6-SULFATASE
(Homo
sapiens)		3 / 3ASN A 289
ASP A  39
ARG A 175
 CA  A 603 (-2.9A)
CA  A 603 (-3.5A)
None
0.89A21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		4xib E3 UBIQUITIN-PROTEIN
LIGASE MIB1
(Homo
sapiens)		3 / 3ASN A 253
ASP A 116
ARG A 149
None
0.74A21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		5e7j ATP-DEPENDENT RNA
HELICASE DDX3X
(Homo
sapiens)		3 / 3ASN A 509
ASP A 354
ARG A 407
None
0.91A20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		5m3x ANGIOTENSINOGEN
(Homo
sapiens)		3 / 3ASN A 246
ASP A 358
ARG A 385
None
0.92Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		5n6w RETINOSCHISIN
(Homo
sapiens)		3 / 3ASN A  85
ASP A 118
ARG A 156
None
0.87A20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens)		3 / 3ASN A2667
ASP A2717
ARG A2511
None
0.80A5.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		6ejb XYLOSYLTRANSFERASE 1
(Homo
sapiens)		3 / 3ASN A 421
ASP A 426
ARG A 557
None
0.85Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		6eoq DIPEPTIDYL PEPTIDASE
9
(Homo
sapiens)		3 / 3ASN A 810
ASP A 763
ARG A 354
None
0.82Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		6eot DIPEPTIDYL PEPTIDASE
8
(Homo
sapiens)		3 / 3ASN A 835
ASP A 788
ARG A 380
None
0.87Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_B_THHB643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		2osa N-CHIMAERIN
(Homo
sapiens)		5 / 12GLU A 291
ASP A 335
ASN A 337
GLY A 296
SER A 294
None
1.18A21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_B_THHB643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		3lmk METABOTROPIC
GLUTAMATE RECEPTOR 5
(Homo
sapiens)		5 / 12GLU A 279
GLY A 280
ASP A 305
VAL A 192
GLY A 150
None
None
GLU  A 506 (-2.7A)
None
None
1.13A20.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K13_B_THHB643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		4ccz METHIONINE SYNTHASE
(Homo
sapiens)		7 / 12ASN A 379
GLY A 382
ASP A 414
VAL A 496
GLY A 576
SER A 578
ASN A 579
THG  A1652 (-4.6A)
THG  A1652 (-3.8A)
None
None
THG  A1652 (-3.6A)
THG  A1652 (-4.2A)
THG  A1652 (-3.1A)
1.50A30.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K13_B_THHB643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		4ccz METHIONINE SYNTHASE
(Homo
sapiens)		7 / 12ASN A 379
GLY A 382
ASP A 449
ASN A 470
VAL A 496
ASN A 579
ARG A 585
THG  A1652 (-4.6A)
THG  A1652 (-3.8A)
THG  A1652 (-3.4A)
THG  A1652 (-3.2A)
None
THG  A1652 (-3.1A)
THG  A1652 (-3.3A)
1.45A30.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K13_B_THHB643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		4ccz METHIONINE SYNTHASE
(Homo
sapiens)		5 / 12ASP A 449
ASN A 470
VAL A 496
GLY A 575
ILE A 611
THG  A1652 (-3.4A)
THG  A1652 (-3.2A)
None
None
THG  A1652 (-4.2A)
1.11A30.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K13_B_THHB643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		4ccz METHIONINE SYNTHASE
(Homo
sapiens)		11 / 12GLU A 376
ASN A 379
GLY A 382
ASP A 449
ASN A 470
VAL A 496
GLY A 576
SER A 578
ASN A 579
ARG A 591
ILE A 611
THG  A1652 (-3.5A)
THG  A1652 (-4.6A)
THG  A1652 (-3.8A)
THG  A1652 (-3.4A)
THG  A1652 (-3.2A)
None
THG  A1652 (-3.6A)
THG  A1652 (-4.2A)
THG  A1652 (-3.1A)
THG  A1652 (-3.0A)
THG  A1652 (-4.2A)
0.30A30.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_B_THHB643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		4fc7 PEROXISOMAL
2,4-DIENOYL-COA
REDUCTASE
(Homo
sapiens)		5 / 12GLY A 213
VAL A 249
GLY A  41
SER A  38
ILE A  40
None
None
None
NAP  A 401 (-2.7A)
NAP  A 401 (-4.0A)
1.19A23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_B_THHB643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		4um8 INTEGRIN ALPHA-V
INTEGRIN BETA-6
(Homo
sapiens;
Homo
sapiens)		5 / 12GLY B 296
ASN B 305
GLY B 274
ASN B 272
ARG A 339
None
None
None
None
SO4  A1597 ( 4.8A)
1.21A17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_B_THHB643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		5epg ALDEHYDE OXIDASE
(Homo
sapiens)		5 / 12ASN A  72
GLY A 346
ASN A 436
ARG A 429
ILE A 349
FES  A3002 ( 3.8A)
None
None
FAD  A3004 (-4.1A)
FAD  A3004 ( 4.3A)
1.18A13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_B_THHB643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		5ugf PURINE NUCLEOSIDE
PHOSPHORYLASE
(Homo
sapiens)		5 / 12GLY A  32
ASN A 243
VAL A 245
GLY A 218
SER A 220
PO4  A 301 (-3.1A)
IM5  A 308 (-3.1A)
IM5  A 308 ( 4.5A)
IM5  A 308 (-3.4A)
PO4  A 301 (-2.5A)
1.26A23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_B_THHB643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens)		5 / 12GLY A 218
ASP A 187
GLY A 212
SER A 215
ASN A 228
None
1.26A21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		2xnh DNA TOPOISOMERASE
2-BINDING PROTEIN 1
(Homo
sapiens)		5 / 12ASN A  53
GLY A  75
ASP A  54
PHE A  68
ILE A  50
None
1.27A18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		3lmk METABOTROPIC
GLUTAMATE RECEPTOR 5
(Homo
sapiens)		5 / 12GLU A 279
GLY A 280
ASP A 305
VAL A 192
GLY A 150
None
None
GLU  A 506 (-2.7A)
None
None
1.14A20.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K13_C_THHC643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		4ccz METHIONINE SYNTHASE
(Homo
sapiens)		10 / 12GLU A 376
ASN A 379
GLY A 382
ASP A 449
VAL A 496
GLY A 576
SER A 578
ASN A 579
ARG A 591
ILE A 611
THG  A1652 (-3.5A)
THG  A1652 (-4.6A)
THG  A1652 (-3.8A)
THG  A1652 (-3.4A)
None
THG  A1652 (-3.6A)
THG  A1652 (-4.2A)
THG  A1652 (-3.1A)
THG  A1652 (-3.0A)
THG  A1652 (-4.2A)
0.27A30.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		4fc7 PEROXISOMAL
2,4-DIENOYL-COA
REDUCTASE
(Homo
sapiens)		5 / 12GLY A 213
VAL A 249
GLY A  41
SER A  38
ILE A  40
None
None
None
NAP  A 401 (-2.7A)
NAP  A 401 (-4.0A)
1.19A23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens)		5 / 12GLY A 218
ASP A 187
GLY A 212
SER A 215
ASN A 228
None
1.26A21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		1a9n U2A'
SPLICEOSOMAL U2B''
(Homo
sapiens;
Homo
sapiens)		3 / 3ASN A  74
ASP A  51
ARG B  28
None
0.91A18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		1ezf FARNESYL-DIPHOSPHATE
FARNESYLTRANSFERASE
(Homo
sapiens)		3 / 3ASN A 205
ASP A 169
ARG A 218
None
0.91A23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		1ozn RETICULON 4 RECEPTOR
(Homo
sapiens)		3 / 3ASN A 164
ASP A 138
ARG A  68
None
0.89A21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		1qgr PROTEIN (IMPORTIN
BETA SUBUNIT)
PROTEIN (IMPORTIN
ALPHA-2 SUBUNIT)
(Homo
sapiens;
Homo
sapiens)		3 / 3ASN A 343
ASP A 337
ARG B  29
None
0.80A16.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K13_C_THHC643_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		4ccz METHIONINE SYNTHASE
(Homo
sapiens)		3 / 3ASN A 470
ASP A 537
ARG A 585
THG  A1652 (-3.2A)
THG  A1652 (-3.4A)
THG  A1652 (-3.3A)
0.81A30.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens)		3 / 3ASN A1016
ASP A 993
ARG A 718
None
0.92A12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		5mms CYSTATHIONINE
BETA-SYNTHASE
(Homo
sapiens)		3 / 3ASN A 294
ASP A 281
ARG A  45
None
0.95A22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		5u1d ANTIGEN PEPTIDE
TRANSPORTER 2
TAP TRANSPORTER
INHIBITOR ICP47
(Homo
sapiens;
Human
alphaherpesvirus
1)		3 / 3ASN B 267
ASP B 432
ARG X  37
None
0.76A18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		6d6q EXOSOME RNA HELICASE
MTR4
(Homo
sapiens)		3 / 3ASN M 219
ASP M 208
ARG M 244
None
0.87Aundetectable