POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3S68_A_TCWA227_1
(CATECHOL
O-METHYLTRANSFERASE)		3bwm CATECHOL
O-METHYLTRANSFERASE
(Homo
sapiens)		10 / 10TRP A  38
MET A  40
ASP A 141
TRP A 143
LYS A 144
ASP A 169
ASN A 170
PRO A 174
LEU A 198
GLU A 199
DNC  A 302 (-4.9A)
SAM  A 301 (-3.7A)
MG  A 300 (-2.4A)
SAM  A 301 ( 3.4A)
DNC  A 302 (-2.7A)
MG  A 300 ( 3.3A)
DNC  A 302 ( 2.5A)
DNC  A 302 ( 4.6A)
DNC  A 302 (-4.5A)
DNC  A 302 (-2.6A)
0.21A81.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		1ypo OXIDISED LOW DENSITY
LIPOPROTEIN
(LECTIN-LIKE)
RECEPTOR 1
(Homo
sapiens)		4 / 6ALA A 253
LEU A 206
SER A 207
THR A 242
None
1.22A20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		3b8k DIHYDROLIPOYLLYSINE-
RESIDUE
ACETYLTRANSFERASE
(Homo
sapiens)		4 / 6LEU A 482
ALA A 503
SER A 527
THR A 529
None
0.76A22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		3bdw NKG2-A/NKG2-B TYPE
II INTEGRAL MEMBRANE
PROTEIN
(Homo
sapiens)		4 / 6LEU B 216
ALA B 209
LEU B 211
SER B 173
None
0.96A21.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		3fc8 TRANSTHYRETIN
(Homo
sapiens)		6 / 6LYS A  15
LEU A  17
ALA A 108
LEU A 110
SER A 117
THR A 119
IFA  A3000 (-3.0A)
IFA  A3000 ( 4.7A)
IFA  A3000 (-3.1A)
IFA  A3000 (-4.1A)
IFA  A3000 (-3.9A)
IFA  A3000 ( 4.9A)
0.30A100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		3kbh ANGIOTENSIN-CONVERTI
NG ENZYME 2
(Homo
sapiens)		4 / 6LYS A  68
LEU A  39
ALA A  65
SER A  44
None
1.05A10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		3sag EXOSOME COMPONENT 10
(Homo
sapiens)		4 / 6LEU A 396
ALA A 392
LEU A 398
THR A 389
LEU  A 396 ( 0.6A)
ALA  A 392 ( 0.0A)
LEU  A 398 ( 0.6A)
THR  A 389 ( 0.8A)
0.86A14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		4q9z HUMAN PROTEIN KINASE
C THETA
(Homo
sapiens)		4 / 6LYS A 409
LEU A 411
LEU A 454
THR A 447
None
None
None
SEP  A 695 ( 4.8A)
0.64A14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens)		4 / 6LYS A 856
LEU A 839
ALA A 853
THR A 849
None
1.20A6.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		5ei0 SERPIN A12
(Homo
sapiens)		4 / 6LYS A 155
LEU A 151
ALA A 160
THR A 137
None
1.25A16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		5emw TRANSCRIPTIONAL
ENHANCER FACTOR
TEF-5
(Homo
sapiens)		4 / 6LEU A 413
ALA A 224
LEU A 228
SER A 326
None
1.11A21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		5vbb RNA PSEUDOURIDYLATE
SYNTHASE
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens)		4 / 6LYS A 167
LEU A 169
LEU A 145
SER A 115
None
1.08A17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		6b0n PGV19 LIGHT CHAIN
(Homo
sapiens)		4 / 6LEU E 132
ALA E 130
LEU E 178
THR E 181
None
1.12A18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		6f3d INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 4
(Homo
sapiens)		4 / 6LYS A 213
LEU A 215
LEU A 258
SER A 253
CJT  A 502 (-3.0A)
None
None
None
1.13A16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		2cum TENASCIN-X
(Homo
sapiens)		4 / 7LEU A  40
ALA A  74
LEU A  76
THR A  90
None
0.72A24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		2f28 SIALIDASE 2
(Homo
sapiens)		4 / 7LEU A 294
ALA A 309
LEU A 311
SER A 322
None
0.84A16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		2ice COMPLEMENT C3 BETA
CHAIN
(Homo
sapiens)		4 / 7LEU A 266
THR A 246
SER A 305
THR A 307
None
0.89A12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		2iq1 PROTEIN PHOSPHATASE
2C KAPPA, PPM1K
(Homo
sapiens)		4 / 7LEU A 201
THR A 191
ALA A 193
LEU A 195
None
0.67A20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		2v9t SLIT HOMOLOG 2
PROTEIN N-PRODUCT
(Homo
sapiens)		4 / 7LEU B 363
THR B 415
ALA B 391
LEU B 367
None
0.97A18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		2wfd LEUCYL-TRNA
SYNTHETASE,
CYTOPLASMIC
(Homo
sapiens)		5 / 7LEU A 269
THR A 293
ALA A 291
LEU A 289
THR A 386
None
1.37A21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		3dxb THIOREDOXIN
N-TERMINALLY FUSED
TO PUF60(UHM)
(Escherichia
coli;
Homo
sapiens)		4 / 7LYS A 426
LEU A 424
ALA A 366
LEU A 368
None
0.79A18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		3f8u TAPASIN
(Homo
sapiens)		4 / 7ALA B 163
LEU B 142
SER B 161
THR B 231
None
None
NAG  B1233 ( 4.6A)
None
0.84A14.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		3fc8 TRANSTHYRETIN
(Homo
sapiens)		5 / 7LYS A  15
LEU A  17
LEU A 110
SER A 117
THR A 119
IFA  A3000 (-3.0A)
IFA  A3000 ( 4.7A)
IFA  A3000 (-4.1A)
IFA  A3000 (-3.9A)
IFA  A3000 ( 4.9A)
0.73A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		3fc8 TRANSTHYRETIN
(Homo
sapiens)		6 / 7LYS A  15
LEU A  17
THR A 106
ALA A 108
LEU A 110
THR A 119
IFA  A3000 (-3.0A)
IFA  A3000 ( 4.7A)
IFA  A3000 (-4.9A)
IFA  A3000 (-3.1A)
IFA  A3000 (-4.1A)
IFA  A3000 ( 4.9A)
0.22A100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		3fhc NUCLEAR PORE COMPLEX
PROTEIN NUP214
(Homo
sapiens)		4 / 7ALA A 175
LEU A 169
SER A 173
THR A 188
None
0.95A16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		3fhc NUCLEAR PORE COMPLEX
PROTEIN NUP214
(Homo
sapiens)		4 / 7LEU A 144
ALA A 175
SER A 173
THR A 188
None
0.96A16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		3nuu PKB-LIKE
(Homo
sapiens)		4 / 7LYS A 111
LEU A 113
LEU A 155
THR A 148
SO4  A   5 (-2.8A)
None
None
SO4  A 369 (-3.7A)
0.79A18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		3sag EXOSOME COMPONENT 10
(Homo
sapiens)		4 / 7LEU A 396
ALA A 392
LEU A 398
THR A 389
LEU  A 396 ( 0.6A)
ALA  A 392 ( 0.0A)
LEU  A 398 ( 0.6A)
THR  A 389 ( 0.8A)
0.83A14.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PYL_A_TCWA303_1
(CATECHOL
O-METHYLTRANSFERASE)		3bwm CATECHOL
O-METHYLTRANSFERASE
(Homo
sapiens)		10 / 10TRP A  38
MET A  40
ASP A 141
TRP A 143
LYS A 144
ASP A 169
ASN A 170
PRO A 174
LEU A 198
GLU A 199
DNC  A 302 (-4.9A)
SAM  A 301 (-3.7A)
MG  A 300 (-2.4A)
SAM  A 301 ( 3.4A)
DNC  A 302 (-2.7A)
MG  A 300 ( 3.3A)
DNC  A 302 ( 2.5A)
DNC  A 302 ( 4.6A)
DNC  A 302 (-4.5A)
DNC  A 302 (-2.6A)
0.26A81.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens)		4 / 6LEU A  79
LEU A  89
SER A  90
VAL A 120
None
None
None
SO4  A 188 (-4.5A)
1.27A19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		2cq2 HYPOTHETICAL PROTEIN
LOC91801
(Homo
sapiens)		4 / 6LEU A 117
ALA A  85
SER A  83
VAL A  71
None
1.23A27.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		2h00 METHYLTRANSFERASE 10
DOMAIN CONTAINING
PROTEIN
(Homo
sapiens)		4 / 6LEU A 129
ALA A 132
LEU A 128
VAL A 121
None
None
SAH  A 300 (-4.7A)
None
1.06A18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		2x2u PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens)		4 / 6LEU A 127
ALA A 143
SER A  32
VAL A 145
None
1.28A15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens)		4 / 6LEU A 306
ALA A 538
LEU A 304
SER A 533
None
1.12A11.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		3fc8 TRANSTHYRETIN
(Homo
sapiens)		5 / 6LYS A  15
LEU A  17
ALA A 108
LEU A 110
VAL A 121
IFA  A3000 (-3.0A)
IFA  A3000 ( 4.7A)
IFA  A3000 (-3.1A)
IFA  A3000 (-4.1A)
None
0.46A99.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		3fc8 TRANSTHYRETIN
(Homo
sapiens)		4 / 6LYS A  15
LEU A  17
LEU A 110
SER A 117
IFA  A3000 (-3.0A)
IFA  A3000 ( 4.7A)
IFA  A3000 (-4.1A)
IFA  A3000 (-3.9A)
0.77A99.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		4fl3 TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens)		4 / 6LEU A 453
ALA A 451
LEU A 502
VAL A 347
None
ANP  A 701 (-4.1A)
None
None
1.28A12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		4keg MALTOSE-BINDING
PERIPLASMIC/PALATE
LUNG AND NASAL
EPITHELIUM CLONE
FUSION PROTEIN
(Escherichia
coli;
Homo
sapiens)		4 / 6LEU A1135
LEU A1157
SER A1186
VAL A1131
None
1.00A12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct)		4 / 6LYS A1844
LEU A1851
SER A1852
VAL A1899
None
1.24A3.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		4um8 INTEGRIN ALPHA-V
(Homo
sapiens)		4 / 6LEU A 170
ALA A 227
SER A 225
VAL A 293
None
1.19A12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		5epg ALDEHYDE OXIDASE
(Homo
sapiens)		4 / 6LYS A 827
ALA A 824
LEU A 610
VAL A 820
None
1.23A6.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		5jjx SQUAMOUS CELL
CARCINOMA ANTIGEN
RECOGNIZED BY
T-CELLS 3
(Homo
sapiens)		4 / 6LEU A 227
LEU A 214
SER A 215
VAL A 177
None
None
None
UNX  A 412 ( 4.5A)
1.12A20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		5kzn METABOTROPIC
GLUTAMATE RECEPTOR 2
(Homo
sapiens)		4 / 6LEU A 278
ALA A 281
LEU A 279
SER A 307
None
1.26A11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		5mw7 PROTEIN JAGGED-2
(Homo
sapiens)		4 / 6LYS A 179
LEU A 181
LEU A 192
VAL A 196
None
0.84A18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6amw TYROSINE-PROTEIN
KINASE ABL1
(Homo
sapiens)		4 / 6LEU A 214
LEU A 141
SER A 140
VAL A 151
None
1.06A21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		6b92 U6 SMALL NUCLEAR RNA
(ADENINE-(43)-N(6))-
METHYLTRANSFERASE
(Homo
sapiens)		4 / 6LEU A 166
ALA A 169
LEU A 165
VAL A 158
None
None
SAH  A 305 ( 4.6A)
None
0.98A17.50