POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_B_TACB1888_1
(ELONGATION FACTOR
EF-TU)		4cca SYNTAXIN-BINDING
PROTEIN 2
(Homo
sapiens)		4 / 5THR A 153
SER A 568
PRO A 150
SER A 567
None
1.25A5.00
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_B_TACB1888_1
(ELONGATION FACTOR
EF-TU)		4oe5 DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens)		4 / 5SER A 412
ASP A 438
PRO A 442
SER A 410
None
1.32A5.92
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_B_TACB1888_1
(ELONGATION FACTOR
EF-TU)		4pl7 ACTIN,THYMOSIN
BETA-4
(Homo
sapiens;
Komagataella
phaffii)		4 / 5THR A 409
ASP A  25
PRO A  27
SER A 344
None
1.21A7.18
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_B_TACB1888_1
(ELONGATION FACTOR
EF-TU)		4u7l LEUCINE-RICH REPEATS
AND
IMMUNOGLOBULIN-LIKE
DOMAINS PROTEIN 1
(Homo
sapiens)		4 / 5THR A 348
SER A 299
ASP A 323
SER A 275
None
1.07A6.58
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_B_TACB1888_1
(ELONGATION FACTOR
EF-TU)		5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2
(Homo
sapiens)		4 / 5SER A 410
ASP A 414
PRO A 412
SER A 408
None
1.36A4.53
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_B_TACB1888_1
(ELONGATION FACTOR
EF-TU)		5tf2 PROLACTIN REGULATORY
ELEMENT-BINDING
PROTEIN
(Homo
sapiens)		4 / 5THR A 367
SER A 309
PRO A 353
SER A 311
None
1.47A6.41
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_B_TACB1888_1
(ELONGATION FACTOR
EF-TU)		5ubz ANTI-HIV1 GP120 MAB
1E12 FAB HEAVY CHAIN
(Homo
sapiens)		4 / 5THR H  73
SER H  52
ASP H  52
SER H  52
None
1.13A22.22
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_B_TACB1888_1
(ELONGATION FACTOR
EF-TU)		5vk2 FAB 37.7H HEAVY
CHAIN
PRE-GLYCOPROTEIN
POLYPROTEIN GP
COMPLEX
(Homo
sapiens;
Lassa
mammarenavirus)		4 / 5SER D 107
ASP a 268
PRO a 275
SER D 104
None
1.47A12.44
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_D_TACD2888_1
(ELONGATION FACTOR
EF-TU)		3hf8 TRYPTOPHAN
5-HYDROXYLASE 1
(Homo
sapiens)		4 / 5SER A 339
THR A 265
SER A 337
PRO A 262
None
ML0  A 401 (-4.4A)
ML0  A 401 (-4.0A)
None
1.38A20.80
8.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_D_TACD2888_1
(ELONGATION FACTOR
EF-TU)		4cca SYNTAXIN-BINDING
PROTEIN 2
(Homo
sapiens)		4 / 5SER A 567
THR A 153
SER A 568
PRO A 150
None
1.24A19.90
5.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_D_TACD2888_1
(ELONGATION FACTOR
EF-TU)		4oe5 DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens)		4 / 5SER A 410
SER A 412
ASP A 438
PRO A 442
None
1.39A20.71
5.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_D_TACD2888_1
(ELONGATION FACTOR
EF-TU)		4pl7 ACTIN,THYMOSIN
BETA-4
(Homo
sapiens;
Komagataella
phaffii)		4 / 5SER A 344
THR A 409
ASP A  25
PRO A  27
None
1.24A21.51
7.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_D_TACD2888_1
(ELONGATION FACTOR
EF-TU)		4u7l LEUCINE-RICH REPEATS
AND
IMMUNOGLOBULIN-LIKE
DOMAINS PROTEIN 1
(Homo
sapiens)		4 / 5SER A 275
THR A 348
SER A 299
ASP A 323
None
1.13A20.17
6.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_D_TACD2888_1
(ELONGATION FACTOR
EF-TU)		5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2
(Homo
sapiens)		4 / 5SER A 408
SER A 410
ASP A 414
PRO A 412
None
1.35A20.33
4.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_D_TACD2888_1
(ELONGATION FACTOR
EF-TU)		5l01 TRYPTOPHAN
5-HYDROXYLASE 1
(Homo
sapiens)		4 / 5SER A 339
THR A 265
SER A 337
PRO A 262
None
6Z4  A 502 (-4.4A)
6Z4  A 502 (-4.0A)
None
1.32A20.77
5.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_D_TACD2888_1
(ELONGATION FACTOR
EF-TU)		5tf2 PROLACTIN REGULATORY
ELEMENT-BINDING
PROTEIN
(Homo
sapiens)		4 / 5SER A 311
THR A 367
SER A 309
PRO A 353
None
1.40A22.45
6.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_D_TACD2888_1
(ELONGATION FACTOR
EF-TU)		5ubz ANTI-HIV1 GP120 MAB
1E12 FAB HEAVY CHAIN
(Homo
sapiens)		4 / 5SER H  52
THR H  73
SER H  52
ASP H  52
None
1.12A13.65
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_D_TACD2888_1
(ELONGATION FACTOR
EF-TU)		6b9g ATLASTIN-1
(Homo
sapiens)		4 / 5SER B 155
THR B 150
SER B 153
ASP B 152
None
1.35A14.89
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)		1n76 LACTOFERRIN
(Homo
sapiens)		4 / 7SER A 114
SER A 156
VAL A 158
LEU A 331
None
1.04A5.60
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)		3ld8 BIFUNCTIONAL
ARGININE DEMETHYLASE
AND
LYSYL-HYDROXYLASE
JMJD6
(Homo
sapiens)		4 / 7THR A 124
ASP A 126
SER A 182
LEU A  87
None
1.05A8.94
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)		4cak INTEGRIN ALPHA-IIB
INTEGRIN BETA-3
(Homo
sapiens)		4 / 7ASP B 288
PRO B 290
VAL B 231
LEU A 390
None
1.05A4.54
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)		4pl7 ACTIN,THYMOSIN
BETA-4
(Homo
sapiens;
Komagataella
phaffii)		4 / 7THR A 409
PRO A  27
SER A 344
LEU A  96
None
1.06A7.18
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)		5j7t UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7
(Homo
sapiens)		4 / 7THR A 247
SER A 255
ASP A 250
LEU A 238
None
0.98A5.17
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)		5n5n TUBULIN BETA CHAIN
(Homo
sapiens)		4 / 7THR B 151
SER B 170
VAL B 172
LEU B 428
None
0.91A6.10
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)		5txf PHOSPHATIDYLCHOLINE-
STEROL
ACYLTRANSFERASE
(Homo
sapiens)		4 / 7THR A 347
ASP A 345
VAL A 381
LEU A  32
None
1.00A7.47
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)		5ufl PROTEIN CIP2A
(Homo
sapiens)		4 / 7ASP A 246
SER A 201
VAL A 204
LEU A 118
None
1.04A5.78
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)		5y4d ANKYRIN-1,ANKYRIN-2,
ANKYRIN-2
(Homo
sapiens;
Mus
musculus)		4 / 7THR A2160
ASP A2162
PRO A1624
LEU A2182
None
1.04A6.50
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_H_TACH4888_1
(ELONGATION FACTOR
EF-TU)		1n76 LACTOFERRIN
(Homo
sapiens)		4 / 7SER A 156
VAL A 158
LEU A 331
SER A 114
None
1.01A19.19
5.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_H_TACH4888_1
(ELONGATION FACTOR
EF-TU)		5n5n TUBULIN BETA CHAIN
(Homo
sapiens)		4 / 7SER B 170
VAL B 172
LEU B 428
THR B 151
None
0.93A23.21
6.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_H_TACH4888_1
(ELONGATION FACTOR
EF-TU)		5txf PHOSPHATIDYLCHOLINE-
STEROL
ACYLTRANSFERASE
(Homo
sapiens)		4 / 7VAL A 381
LEU A  32
THR A 347
ASP A 345
None
0.99A23.64
7.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_H_TACH4888_1
(ELONGATION FACTOR
EF-TU)		5ufl PROTEIN CIP2A
(Homo
sapiens)		4 / 7SER A 201
VAL A 204
LEU A 118
ASP A 246
None
1.00A20.50
5.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_H_TACH4888_1
(ELONGATION FACTOR
EF-TU)		5y4d ANKYRIN-1,ANKYRIN-2,
ANKYRIN-2
(Homo
sapiens;
Mus
musculus)		4 / 7LEU A2182
THR A2160
ASP A2162
PRO A1624
None
1.05A20.03
6.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_J_TACJ5888_1
(ELONGATION FACTOR
EF-TU)		2jbm NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Homo
sapiens)		4 / 6SER A 250
ASP A 224
SER A 270
VAL A 268
None
1.11A9.47
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_J_TACJ5888_1
(ELONGATION FACTOR
EF-TU)		2kpk MEMBRANE-ASSOCIATED
GUANYLATE KINASE, WW
AND PDZ
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens)		4 / 6THR A 112
ASP A 109
PRO A 107
VAL A  32
None
1.10A15.32
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_J_TACJ5888_1
(ELONGATION FACTOR
EF-TU)		2qob EPHRIN RECEPTOR
(Homo
sapiens)		4 / 6SER A 738
ASP A 739
SER A 803
VAL A 807
None
1.25A8.56
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_J_TACJ5888_1
(ELONGATION FACTOR
EF-TU)		2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens)		4 / 6SER A 792
ASP A 793
SER A 857
VAL A 861
None
0.94A9.06
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_J_TACJ5888_1
(ELONGATION FACTOR
EF-TU)		3f6u VITAMIN K-DEPENDENT
PROTEIN C HEAVY
CHAIN
(Homo
sapiens)		4 / 6THR H  22
SER H  27
ASP H  26
VAL H 200
None
1.18A9.21
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_J_TACJ5888_1
(ELONGATION FACTOR
EF-TU)		3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens)		4 / 6SER A 752
ASP A 753
SER A 817
VAL A 821
None
SO4  A 910 ( 4.1A)
None
None
1.26A9.00
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_J_TACJ5888_1
(ELONGATION FACTOR
EF-TU)		4bsk VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 3
(Homo
sapiens)		4 / 6ASP A 187
PRO A 163
SER A  38
VAL A  40
None
1.18A9.48
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_J_TACJ5888_1
(ELONGATION FACTOR
EF-TU)		4cca SYNTAXIN-BINDING
PROTEIN 2
(Homo
sapiens)		4 / 6THR A 153
SER A 568
PRO A 150
SER A 567
None
1.24A5.00
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_J_TACJ5888_1
(ELONGATION FACTOR
EF-TU)		4f7o COP9 SIGNALOSOME
COMPLEX SUBUNIT 5
(Homo
sapiens)		4 / 6THR A 173
ASP A 171
PRO A 141
VAL A  77
None
1.17A13.38
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_J_TACJ5888_1
(ELONGATION FACTOR
EF-TU)		5c08 1E6 TCR ALPHA CHAIN
1E6 TCR BETA CHAIN
(Homo
sapiens)		4 / 6THR D 156
ASP E 175
PRO E 178
VAL E 157
None
1.30A10.27
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_J_TACJ5888_1
(ELONGATION FACTOR
EF-TU)		5ubz ANTI-HIV1 GP120 MAB
1E12 FAB HEAVY CHAIN
(Homo
sapiens)		4 / 6THR H  73
SER H  52
ASP H  52
SER H  52
None
1.14A22.22
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_L_TACL6888_1
(ELONGATION FACTOR
EF-TU)		1awb MYO-INOSITOL
MONOPHOSPHATASE
(Homo
sapiens)		4 / 6SER A 124
VAL A 126
THR A 195
ASP A  93
None
None
None
IPD  A 281 (-3.0A)
1.24A21.94
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_L_TACL6888_1
(ELONGATION FACTOR
EF-TU)		2jbm NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Homo
sapiens)		4 / 6SER A 270
VAL A 268
SER A 250
ASP A 224
None
1.15A22.91
9.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_L_TACL6888_1
(ELONGATION FACTOR
EF-TU)		2kpk MEMBRANE-ASSOCIATED
GUANYLATE KINASE, WW
AND PDZ
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens)		4 / 6VAL A  32
THR A 112
ASP A 109
PRO A 107
None
1.14A17.01
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_L_TACL6888_1
(ELONGATION FACTOR
EF-TU)		2qob EPHRIN RECEPTOR
(Homo
sapiens)		4 / 6SER A 803
VAL A 807
SER A 738
ASP A 739
None
1.25A22.25
8.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_L_TACL6888_1
(ELONGATION FACTOR
EF-TU)		3f6u VITAMIN K-DEPENDENT
PROTEIN C HEAVY
CHAIN
(Homo
sapiens)		4 / 6VAL H 200
THR H  22
SER H  27
ASP H  26
None
1.24A20.81
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_L_TACL6888_1
(ELONGATION FACTOR
EF-TU)		3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens)		4 / 6SER A 817
VAL A 821
SER A 752
ASP A 753
None
None
None
SO4  A 910 ( 4.1A)
1.25A23.51
9.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_L_TACL6888_1
(ELONGATION FACTOR
EF-TU)		4bsk VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 3
(Homo
sapiens)		4 / 6SER A  38
VAL A  40
ASP A 187
PRO A 163
None
1.07A20.12
9.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_L_TACL6888_1
(ELONGATION FACTOR
EF-TU)		4cca SYNTAXIN-BINDING
PROTEIN 2
(Homo
sapiens)		4 / 6SER A 567
THR A 153
SER A 568
PRO A 150
None
1.23A19.90
5.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_L_TACL6888_1
(ELONGATION FACTOR
EF-TU)		4pl7 ACTIN,THYMOSIN
BETA-4
(Homo
sapiens;
Komagataella
phaffii)		4 / 6SER A 344
THR A 409
ASP A  25
PRO A  27
None
1.22A21.51
7.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_L_TACL6888_1
(ELONGATION FACTOR
EF-TU)		4xey TYROSINE-PROTEIN
KINASE ABL1
(Homo
sapiens)		4 / 6SER B 439
VAL B 441
SER B 436
ASP B 410
None
1.16A22.40
8.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_L_TACL6888_1
(ELONGATION FACTOR
EF-TU)		5ubz ANTI-HIV1 GP120 MAB
1E12 FAB HEAVY CHAIN
(Homo
sapiens)		4 / 6SER H  52
THR H  73
SER H  52
ASP H  52
None
1.14A13.65
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXO_B_TACB1211_1
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		2b5m DAMAGE-SPECIFIC DNA
BINDING PROTEIN 1
(Homo
sapiens)		5 / 11LEU A 699
LEU A 673
VAL A 676
LEU A 425
ILE A 704
None
1.22A11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXO_B_TACB1211_1
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		2pla GLYCEROL-3-PHOSPHATE
DEHYDROGENASE 1-LIKE
PROTEIN
(Homo
sapiens)		5 / 11LEU A 182
VAL A  20
LEU A  90
VAL A  94
ILE A  10
None
None
None
NAD  A 401 ( 4.8A)
None
1.07A21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXO_B_TACB1211_1
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		2vo1 CTP SYNTHASE 1
(Homo
sapiens)		5 / 11LEU A 267
VAL A 262
LEU A  32
CYH A 176
ILE A  26
None
1.19A20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXO_B_TACB1211_1
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		2vxo GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]
(Homo
sapiens)		5 / 11LEU A 511
LEU A 618
ASN A 463
LEU A 466
VAL A 568
None
1.11A17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXO_B_TACB1211_1
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		3a6p EXPORTIN-5
(Homo
sapiens)		5 / 11LEU A 553
LEU A 466
VAL A 538
LEU A 577
ILE A 514
None
1.22A11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXO_B_TACB1211_1
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		3qye TBC1 DOMAIN FAMILY
MEMBER 1
(Homo
sapiens)		5 / 11HIS A 794
LEU A 992
ASN A1043
ILE A 809
ILE A1042
None
1.16A20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXO_B_TACB1211_1
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		4gn1 RAS-ASSOCIATED AND
PLECKSTRIN HOMOLOGY
DOMAINS-CONTAINING
PROTEIN 1
(Homo
sapiens)		5 / 11LEU A 297
VAL A 296
MET A 277
VAL A 275
ILE A 273
None
1.17A19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXO_B_TACB1211_1
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		4nc6 RAB
GTPASE-ACTIVATING
PROTEIN 1
(Homo
sapiens)		5 / 11LEU A 680
LEU A 749
LEU A 683
VAL A 755
ILE A 756
None
1.19A19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXO_B_TACB1211_1
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		5gtm INTERFERON-INDUCED
GTP-BINDING PROTEIN
MX1
(Homo
sapiens)		5 / 11LEU A 331
LEU A  90
ILE A 245
VAL A  75
ILE A 177
None
1.06A14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXO_B_TACB1211_1
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		5loh SERINE/THREONINE-PRO
TEIN KINASE
GREATWALL,SERINE/THR
EONINE-PROTEIN
KINASE GREATWALL
(Homo
sapiens)		5 / 11LEU A 122
VAL A 118
LEU A 144
MET A 132
ILE A 170
None
1.16A21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXO_B_TACB1211_1
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens)		5 / 11LEU A 239
LEU A 232
VAL A 220
LEU A 167
VAL A 171
None
1.08A14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXO_B_TACB1211_1
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		5u03 CTP SYNTHASE 1
(Homo
sapiens)		5 / 11LEU A 267
LEU A 213
VAL A 262
VAL A  23
ILE A  26
None
1.11A16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXO_B_TACB1211_1
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		5uos METHYLMALONIC
ACIDURIA AND
HOMOCYSTINURIA TYPE
C PROTEIN
(Homo
sapiens)		5 / 11LEU A  51
LEU A 166
VAL A 164
LEU A  53
VAL A  90
None
1.19A23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXO_B_TACB1211_1
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens)		5 / 11LEU A 264
VAL A 175
LEU A 318
ILE A 243
ILE A 291
None
1.22A20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXO_B_TACB1211_1
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		5xgs RCC1-LIKE G
EXCHANGING
FACTOR-LIKE PROTEIN
(Homo
sapiens)		5 / 11ASN A 421
LEU A 431
MET A 442
VAL A 440
ILE A 428
None
1.16A19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5P_A_TACA7101_1
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		1jkw CYCLIN H
(Homo
sapiens)		5 / 12PRO A 163
ILE A 212
TYR A 164
TYR A 204
TYR A  86
None
1.06A23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5P_A_TACA7101_1
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		1mi1 NEUROBEACHIN
(Homo
sapiens)		5 / 12ASN A2366
TYR A2363
ILE A2491
TYR A2513
TYR A2348
None
1.04A20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5P_A_TACA7101_1
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		1ul1 FLAP ENDONUCLEASE-1
(Homo
sapiens)		5 / 12PRO X  81
VAL X  31
TYR X  26
ILE X 150
ILE X  23
None
1.45A21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5P_A_TACA7101_1
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		1ygu LEUKOCYTE COMMON
ANTIGEN
(Homo
sapiens)		5 / 12ASN A 947
TYR A 992
ILE A1142
PHE A1021
ILE A 993
None
1.40A18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5P_A_TACA7101_1
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		3g9v INTERLEUKIN 22
RECEPTOR, ALPHA 2
(Homo
sapiens)		5 / 12ASN A  40
ILE A 145
TYR A 171
GLU A 164
ILE A 163
None
1.49A22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5P_A_TACA7101_1
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		3hdn SERINE/THREONINE-PRO
TEIN KINASE SGK1
(Homo
sapiens)		5 / 12TYR A 292
ILE A 228
TYR A 263
PHE A 194
GLU A 289
None
1.41A22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5P_A_TACA7101_1
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		4cem REGULATOR OF
NONSENSE TRANSCRIPTS
2
(Homo
sapiens)		5 / 12VAL A 175
ASN A 171
PHE A 236
ILE A 202
TYR A 233
None
1.06A22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5P_A_TACA7101_1
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		4lik DNA PRIMASE SMALL
SUBUNIT
(Homo
sapiens)		5 / 12PRO A 344
VAL A 347
TYR A 391
ILE A 127
ILE A 334
None
1.27A20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5P_A_TACA7101_1
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		4s15 NUCLEAR RECEPTOR
ROR-ALPHA
(Homo
sapiens)		5 / 12VAL A 379
ASN A 377
ILE A 327
PHE A 399
ILE A 400
None
1.27A23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5P_A_TACA7101_1
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		5e7j ATP-DEPENDENT RNA
HELICASE DDX3X
(Homo
sapiens)		5 / 12PRO A 297
VAL A 295
TYR A 243
ILE A 238
TYR A 343
None
1.35A21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5P_A_TACA7101_1
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		5hx6 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 1
(Homo
sapiens)		5 / 12VAL A 216
TYR A 228
ILE A 144
TYR A 192
GLU A 226
None
1.43A23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3A_A_TACA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		1itu RENAL DIPEPTIDASE
(Homo
sapiens)		5 / 12LEU A  42
PHE A 100
PRO A  24
VAL A  88
SER A 120
None
1.38A22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3A_A_TACA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		2a9m FLUORESCEIN-SCFV
HEAVY CHAIN
(Homo
sapiens)		5 / 12LEU H   4
ASN H  87
PHE H  29
ARG H 109
VAL H  89
None
1.39A20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3A_A_TACA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		2a9m FLUORESCEIN-SCFV
HEAVY CHAIN
(Homo
sapiens)		5 / 12LEU H   4
SER H  88
ASN H  87
PHE H  29
ARG H 109
None
1.49A20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3A_A_TACA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		2d39 FICOLIN-1
(Homo
sapiens)		5 / 12LEU A 208
SER A 315
ASN A 305
GLN A 216
SER A 247
None
1.42A20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3A_A_TACA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		2d99 GENERAL
TRANSCRIPTION FACTOR
II-I REPEAT
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens)		5 / 12SER A  73
PHE A  78
ARG A  57
PRO A  58
VAL A  12
None
1.50A18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3A_A_TACA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		3o2s RNA POLYMERASE II
SUBUNIT A C-TERMINAL
DOMAIN PHOSPHATASE
SSU72
(Homo
sapiens)		5 / 12LEU B  85
ARG B  94
PRO B  95
GLN B  16
VAL B  42
None
1.32A20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3A_A_TACA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		4asi ACETYL-COA
CARBOXYLASE 1
(Homo
sapiens)		5 / 12SER A2059
PHE A2061
ARG A1874
VAL A2010
ILE A2067
None
1.45A15.41