POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		1w6j LANOSTEROL SYNTHASE
(Homo
sapiens)		5 / 12GLN A 135
ARG A 177
ASN A 178
GLY A 140
GLY A 167
None
1.18A19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		1ya0 SMG-7 TRANSCRIPT
VARIANT 2
(Homo
sapiens)		5 / 12THR A 298
GLY A 340
ALA A 358
ASN A 357
GLN A 456
None
1.16A23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		2ver AFIMBRIAL ADHESIN
AFA-III
ARCINOEMBRYONIC
ANTIGEN-RELATED CELL
ADHESION MOLECULE 5
(Escherichia
coli;
Homo
sapiens)		5 / 12THR A  95
GLY A   8
ALA N  55
GLY N  47
GLN N  53
MTN  N1111 ( 4.7A)
None
None
None
None
1.25A15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		3bpt 3-HYDROXYISOBUTYRYL-
COA HYDROLASE
(Homo
sapiens)		5 / 12GLN A 313
PHE A 183
GLY A 181
ALA A 166
GLY A 199
None
1.19A22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		3cem GLYCOGEN
PHOSPHORYLASE, LIVER
FORM
(Homo
sapiens)		5 / 12THR A 487
PHE A 811
GLY A 809
GLY A 677
ASN A 696
None
None
None
PLP  A 832 (-3.8A)
None
1.27A20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		3dlj BETA-ALA-HIS
DIPEPTIDASE
(Homo
sapiens)		5 / 12ASN A 140
GLY A 445
GLY A 134
ASN A 455
GLN A 454
 ZN  A2002 ( 4.7A)
None
None
None
None
1.25A23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		4bkw ZINC FINGER FYVE
DOMAIN-CONTAINING
PROTEIN 9
(Homo
sapiens)		5 / 12THR A1312
ARG A1310
GLY A 969
ALA A1008
GLY A1009
None
1.24A21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		4oe5 DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens)		5 / 12THR A 237
ASN A 211
GLY A 266
GLY A 216
ASN A 283
None
1.05A21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		5nvm EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E
TYPE 2
(Homo
sapiens)		5 / 12GLN A  84
ASN A  59
GLY A  86
ALA A 169
GLY A 168
None
1.17A19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_B_T1CB405_1
(TETX2 PROTEIN)		1i2m REGULATOR OF
CHROMOSOME
CONDENSATION 1
(Homo
sapiens)		5 / 12PHE B  91
ASN B  94
GLY B 113
ALA B  74
GLY B  75
None
1.23A23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_B_T1CB405_1
(TETX2 PROTEIN)		2dm0 TYROSINE-PROTEIN
KINASE TXK
(Homo
sapiens)		5 / 12ASN A 102
HIS A 101
PRO A 113
ALA A  40
GLY A  39
None
1.31A14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_B_T1CB405_1
(TETX2 PROTEIN)		2dw4 LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1
(Homo
sapiens)		5 / 12GLN A 554
GLY A 770
PRO A 808
ALA A 814
GLY A 813
None
None
None
FAD  A1001 (-3.4A)
None
1.25A20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_B_T1CB405_1
(TETX2 PROTEIN)		2iwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE
(Homo
sapiens)		5 / 12PHE A 445
GLY A 446
ALA A 357
GLU A 419
ASN A 360
None
6NA  A1460 (-3.3A)
None
None
None
1.23A19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_B_T1CB405_1
(TETX2 PROTEIN)		3lpp SUCRASE-ISOMALTASE
(Homo
sapiens)		5 / 12GLN A 245
GLY A 243
ALA A 599
GLY A 598
ASN A 572
None
1.14A18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_B_T1CB405_1
(TETX2 PROTEIN)		5yax SCFV1 ANTIBODY
(Homo
sapiens)		5 / 12GLN A1006
PHE A1118
ASN A1029
GLY A1119
ALA A 114
None
1.22A19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_B_T1CB405_1
(TETX2 PROTEIN)		6bbp CYTOHESIN-3,ADP-RIBO
SYLATION FACTOR 6
(Homo
sapiens;
Mus
musculus)		5 / 12ASN A 112
GLY A 108
GLY A  84
GLU A  90
ASN A  91
None
1.29A14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_C_T1CC401_1
(TETX2 PROTEIN)		2md7 NUCLEAR BODY PROTEIN
SP140
(Homo
sapiens)		5 / 11ASP B  24
ARG B   6
HIS B  35
GLY B  18
PRO B  45
None
None
ZN  B 102 (-2.9A)
None
None
1.34A9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_C_T1CC401_1
(TETX2 PROTEIN)		3fby CARTILAGE OLIGOMERIC
MATRIX PROTEIN
(Homo
sapiens)		5 / 11GLN A 604
GLY A 440
SER A 454
PRO A 690
GLY A 693
None
1.40A20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_C_T1CC401_1
(TETX2 PROTEIN)		4ci8 ECHINODERM
MICROTUBULE-ASSOCIAT
ED PROTEIN-LIKE 1
(Homo
sapiens)		5 / 11PHE A 464
HIS A 459
GLY A 462
PRO A 505
GLY A 520
None
1.47A20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_C_T1CC401_1
(TETX2 PROTEIN)		4v0h METALLO-BETA-LACTAMA
SE DOMAIN-CONTAINING
PROTEIN 1 1
(Homo
sapiens)		5 / 11ARG A 220
HIS A 172
GLY A 194
SER A  46
GLY A 201
None
FE  A1242 (-3.4A)
None
None
None
1.49A22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_C_T1CC401_1
(TETX2 PROTEIN)		5fcs DIABODY
(Homo
sapiens)		5 / 11GLN L 157
PHE H 100
GLY L 162
PRO H  46
GLY H  48
None
1.50A19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_D_T1CD401_1
(TETX2 PROTEIN)		2pb7 E3 UBIQUITIN-PROTEIN
LIGASE UHRF1
(Homo
sapiens)		5 / 10HIS A 442
GLN A 499
ASN A 503
GLY A 483
GLY A 448
None
1.31A21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_D_T1CD401_1
(TETX2 PROTEIN)		3dwh E3 UBIQUITIN-PROTEIN
LIGASE UHRF1
(Homo
sapiens)		5 / 10HIS A 442
GLN A 499
ASN A 503
GLY A 483
GLY A 448
None
1.41A18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_A_T1CA392_1
(TETX2 PROTEIN)		1i2m REGULATOR OF
CHROMOSOME
CONDENSATION 1
(Homo
sapiens)		5 / 11PHE B  91
ASN B  94
GLY B 113
ALA B  74
GLY B  75
None
1.26A23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_A_T1CA392_1
(TETX2 PROTEIN)		3lpp SUCRASE-ISOMALTASE
(Homo
sapiens)		5 / 11GLN A 245
GLY A 243
ALA A 599
GLY A 598
ASN A 572
None
1.13A19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_A_T1CA392_1
(TETX2 PROTEIN)		3pvo C-REACTIVE PROTEIN
(Homo
sapiens)		5 / 11GLN A 139
PHE A 142
GLY A 143
ALA A 129
GLY A 128
None
0.96A20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_A_T1CA392_1
(TETX2 PROTEIN)		4ayz HEME-BINDING PROTEIN
2
(Homo
sapiens)		5 / 11ASN A  70
GLY A  65
ALA A 177
GLY A 178
GLU A 191
None
1.14A20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_A_T1CA392_1
(TETX2 PROTEIN)		4um8 INTEGRIN ALPHA-V
INTEGRIN BETA-6
(Homo
sapiens)		5 / 11PHE B 259
GLY B 260
PRO A 244
ALA A 246
GLY A 251
None
1.30A19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_A_T1CA392_1
(TETX2 PROTEIN)		5gqq HEME-BINDING PROTEIN
2
(Homo
sapiens)		5 / 11ASN A  70
GLY A  65
ALA A 177
GLY A 178
GLU A 191
None
1.17A17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_A_T1CA392_1
(TETX2 PROTEIN)		5mvd DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL
(Homo
sapiens)		5 / 11GLY A 128
ALA A  96
GLY A  97
GLU A 117
ASN A 181
None
FMN  A 401 (-3.4A)
FMN  A 401 (-3.3A)
None
FMN  A 401 (-3.1A)
1.25A22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_A_T1CA392_1
(TETX2 PROTEIN)		5nvm EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E
TYPE 2
(Homo
sapiens)		5 / 11GLN A  84
ASN A  59
GLY A  86
ALA A 169
GLY A 168
None
1.03A18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_A_T1CA392_1
(TETX2 PROTEIN)		5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens)		5 / 11GLN C3564
ARG C3696
GLY C3565
ALA C3574
MET C3796
None
1.23A7.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_B_T1CB392_1
(TETX2 PROTEIN)		4z94 GELSOLIN,
TROPOMODULIN-1,
LEIOMODIN-1 CHIMERA
(Homo
sapiens)		5 / 11PHE G1422
ASN G1424
HIS G1453
GLY G1451
GLY G1430
None
1.33A21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_B_T1CB392_1
(TETX2 PROTEIN)		5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens)		5 / 11GLN C3564
ARG C3696
ASN C3697
GLY C3565
MET C3796
None
1.44A7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_C_T1CC392_1
(TETX2 PROTEIN)		2r4f 3-HYDROXY-3-METHYLGL
UTARYL-COENZYME A
REDUCTASE
(Homo
sapiens)		5 / 11ASN A 686
MET A 588
GLY A 591
SER A 684
GLY A 773
RIE  A 876 ( 4.8A)
None
None
RIE  A 876 (-2.5A)
None
1.47A23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_C_T1CC392_1
(TETX2 PROTEIN)		2wim NEURAL CELL ADHESION
MOLECULE 2
(Homo
sapiens)		5 / 11ASN A 273
ASN A 219
GLY A 276
SER A 274
GLY A 225
None
NAG  A 951 (-1.8A)
None
None
None
1.49A20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_C_T1CC392_1
(TETX2 PROTEIN)		3fby CARTILAGE OLIGOMERIC
MATRIX PROTEIN
(Homo
sapiens)		5 / 11GLN A 604
GLY A 440
SER A 454
PRO A 690
GLY A 693
None
1.40A19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_C_T1CC392_1
(TETX2 PROTEIN)		5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens)		5 / 11ASN A1016
ARG A1259
ASN A1062
GLY A 980
GLY A 987
None
1.14A13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_C_T1CC392_1
(TETX2 PROTEIN)		5knm LEUKOCYTE
IMMUNOGLOBULIN-LIKE
RECEPTOR SUBFAMILY B
MEMBER 1
(Homo
sapiens)		5 / 11ASN D 146
ASN D 180
GLY D 130
SER D 132
GLY D  71
None
0.90A19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_C_T1CC392_1
(TETX2 PROTEIN)		5lb8 ATP-DEPENDENT DNA
HELICASE Q5
(Homo
sapiens)		5 / 11ASN A 285
GLY A 283
SER A 280
PRO A 311
GLY A 262
None
1.32A20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_C_T1CC392_1
(TETX2 PROTEIN)		5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens)		5 / 11GLN C3564
ARG C3696
ASN C3697
GLY C3565
MET C3796
None
1.44A7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_D_T1CD392_1
(TETX2 PROTEIN)		5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens)		5 / 9GLN C3564
ARG C3696
ASN C3697
GLY C3565
MET C3796
None
1.44A7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ABZ_A_T1CA1209_1
(TETRACYCLINE
REPRESSOR CLASS D)		1xfd DIPEPTIDYL
AMINOPEPTIDASE-LIKE
PROTEIN 6
(Homo
sapiens)		5 / 12HIS A 301
SER A 214
GLN A 243
THR A 216
LEU A 254
None
1.41A16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ABZ_A_T1CA1209_1
(TETRACYCLINE
REPRESSOR CLASS D)		5hkj COMPLEMENT C1Q
SUBCOMPONENT SUBUNIT
A,COMPLEMENT C1Q
SUBCOMPONENT SUBUNIT
C,COMPLEMENT C1Q
SUBCOMPONENT SUBUNIT
B
(Homo
sapiens)		5 / 12ASN A 309
PRO A 406
GLN A 277
THR A 276
LEU A 233
None
1.42A19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ABZ_A_T1CA1209_1
(TETRACYCLINE
REPRESSOR CLASS D)		5udy ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 7
(Homo
sapiens)		5 / 12HIS A  79
HIS A 247
ARG A 212
PRO A 198
LEU A  54
None
ZN  A 501 (-3.1A)
None
None
None
1.48A20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ABZ_A_T1CA1209_1
(TETRACYCLINE
REPRESSOR CLASS D)		6en4 SPLICING FACTOR 3B
SUBUNIT 3
SPLICING FACTOR 3B
SUBUNIT 5
(Homo
sapiens)		5 / 12ARG A 429
PRO A 406
THR A1103
LEU B  50
SER A  15
None
1.42A16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ABZ_A_T1CA1209_1
(TETRACYCLINE
REPRESSOR CLASS D)		6en4 SPLICING FACTOR 3B
SUBUNIT 3
SPLICING FACTOR 3B
SUBUNIT 5
(Homo
sapiens)		5 / 12HIS A 356
ARG A 429
THR A1103
LEU B  50
SER A  15
None
1.31A16.75