POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_1
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		3bg9 PYRUVATE
CARBOXYLASE,
MITOCHONDRIAL
(Homo
sapiens)		5 / 12THR A 908
VAL A 907
THR A 611
VAL A 614
GLU A 605
None
1.35A20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_1
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		3ihj ALANINE
AMINOTRANSFERASE 2
(Homo
sapiens)		5 / 12THR A 168
VAL A 174
GLN A 303
GLU A 300
ILE A 181
None
1.35A21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_1
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		3rom ADP-RIBOSYL CYCLASE
1
(Homo
sapiens)		5 / 12VAL A  85
GLN A 115
THR A 116
VAL A 117
TYR A  70
None
1.49A19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_1
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR
(Homo
sapiens)		5 / 12THR A 662
VAL A 653
GLN A 668
VAL A 832
HIS A 648
None
1.49A18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_1
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		4ez5 CYCLIN-DEPENDENT
KINASE 6
(Homo
sapiens)		5 / 12VAL A 117
THR A 154
VAL A 101
GLN A 158
ILE A 151
None
None
0RS  A 900 (-4.5A)
None
None
1.16A20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_1
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		4k3g IMMUNOGLOBULIN
LAMBDA VARIABLE
DOMAIN L5(L89S)
(Homo
sapiens)		5 / 12THR A 105
VAL A 106
GLN A 103
GLU A  85
ILE A  75
None
1.48A12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_1
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		4yvd PLEIOTROPIC
REGULATOR 1
(Homo
sapiens)		5 / 12VAL A 450
THR A 420
VAL A 379
ILE A 416
HIS A 412
None
UNX  A 615 ( 3.8A)
UNX  A 617 ( 4.1A)
None
None
1.33A20.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4S0V_A_SUVA2001_1
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		4zj8 HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE
(Homo
sapiens;
Pyrococcus
abyssi)		10 / 12VAL A 106
TRP A 112
GLN A 126
VAL A 130
GLN A 179
GLU A 204
ILE A 314
ASN A 318
HIS A 344
TYR A 348
SUV  A2001 (-4.5A)
None
SUV  A2001 (-3.8A)
SUV  A2001 (-4.7A)
SUV  A2001 (-3.3A)
SUV  A2001 (-4.4A)
SUV  A2001 (-3.8A)
SUV  A2001 (-2.9A)
SUV  A2001 (-3.5A)
SUV  A2001 (-4.8A)
0.52A83.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_1
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		5fcs DIABODY
(Homo
sapiens)		5 / 12THR L  81
VAL L 109
GLN L 121
GLU L 119
ILE L  76
None
1.49A16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_1
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		5fcs DIABODY
(Homo
sapiens)		5 / 12THR L  81
VAL L 109
GLN L 121
GLU L 119
TYR L  87
None
1.48A16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_2
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		2jfe CYTOSOLIC
BETA-GLUCOSIDASE
(Homo
sapiens)		4 / 5ILE X  66
HIS X 120
TYR X 370
VAL X 413
None
1.34A21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_2
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		2oud DUAL SPECIFICITY
PROTEIN PHOSPHATASE
10
(Homo
sapiens)		4 / 5ILE A 444
PRO A 443
HIS A 491
VAL A 419
None
1.32A14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_2
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		4d9r COMPLEMENT FACTOR D
(Homo
sapiens)		4 / 5ILE A 143
HIS A 157
TYR A 228
VAL A 213
None
1.36A15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_2
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		4jpz FIBROBLAST GROWTH
FACTOR 13
SODIUM CHANNEL
PROTEIN TYPE 2
SUBUNIT ALPHA
(Homo
sapiens)		4 / 5ILE A  52
PRO A  53
HIS B1853
VAL A 100
None
1.27A17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_2
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		4nky STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE
(Homo
sapiens)		4 / 5ILE A 479
PRO A 480
HIS A 401
VAL A 310
None
1.27A22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_2
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		4oya ADENYLATE CYCLASE
TYPE 10
(Homo
sapiens)		4 / 5ILE A 277
PRO A  12
TYR A  26
VAL A  25
None
1.36A21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_2
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		4pj3 INTRON-BINDING
PROTEIN AQUARIUS
(Homo
sapiens)		4 / 5ILE A 432
PRO A 428
TYR A 650
VAL A 649
None
1.09A16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_2
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		4z96 UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7
(Homo
sapiens)		4 / 5ILE A 949
PRO A1006
HIS A1081
VAL A1043
None
1.32A21.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4S0V_A_SUVA2001_2
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		4zj8 HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE
(Homo
sapiens;
Pyrococcus
abyssi)		5 / 5ILE A 122
PRO A 123
HIS A 216
TYR A 311
VAL A 347
SUV  A2001 ( 4.8A)
SUV  A2001 (-3.9A)
SUV  A2001 ( 4.8A)
None
SUV  A2001 ( 4.6A)
0.34A83.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_2
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		5fql IDURONATE-2-SULFATAS
E
(Homo
sapiens)		4 / 5ILE A  42
HIS A 356
TYR A 300
VAL A 304
None
1.34A21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_2
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		5jtv UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7
(Homo
sapiens)		4 / 5ILE A 949
PRO A1006
HIS A1081
VAL A1043
None
1.31A20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_2
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		5n48 FIBRONECTIN
NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN
(Homo
sapiens)		4 / 5ILE A  97
PRO A 103
TYR B1323
VAL B1325
None
1.16A9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_2
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		5wy0 SMALL RNA
2'-O-METHYLTRANSFERA
SE
(Homo
sapiens)		4 / 5ILE A 128
PRO A 125
TYR A 220
VAL A  47
None
1.34A10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_2
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		6c01 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 3
(Homo
sapiens)		4 / 5ILE A 750
PRO A 749
TYR A 646
VAL A 745
None
1.36A8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_2
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		6ei1 ZINC FINGER WITH
UFM1-SPECIFIC
PEPTIDASE DOMAIN
PROTEIN
(Homo
sapiens)		4 / 5ILE A 484
PRO A 483
TYR A 330
VAL A 340
None
1.21A9.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_2
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		6g79 5-HYDROXYTRYPTAMINE
RECEPTOR 1B
(Homo
sapiens)		4 / 5ILE S 367
PRO S 366
HIS S 139
TYR S 228
None
1.36A11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJ8_A_SUVA2001_1
(HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE)		2c11 MEMBRANE COPPER
AMINE OXIDASE
(Homo
sapiens)		5 / 12ALA A 676
VAL A 678
VAL A 352
GLU A 486
PHE A 479
None
1.27A22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJ8_A_SUVA2001_1
(HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE)		2o8e DNA MISMATCH REPAIR
PROTEIN MSH6
(Homo
sapiens)		5 / 12SER B 564
GLN B 522
VAL B 474
GLN B 593
TYR B 524
None
1.45A19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJ8_A_SUVA2001_1
(HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE)		3h32 FIBRINOGEN BETA
CHAIN
(Homo
sapiens)		5 / 12ALA B 410
VAL B 436
GLU B 291
PHE B 273
TYR B 404
None
1.47A20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJ8_A_SUVA2001_1
(HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE)		3l5k HALOACID
DEHALOGENASE-LIKE
HYDROLASE
DOMAIN-CONTAINING
PROTEIN 1A
(Homo
sapiens)		5 / 12ALA A 118
SER A 119
GLN A  79
VAL A  75
GLU A  84
None
CL  A 232 (-3.4A)
None
None
None
1.29A17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJ8_A_SUVA2001_1
(HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE)		4er6 HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC
(Homo
sapiens)		5 / 12ALA A 273
VAL A 293
VAL A 249
MET A 260
PHE A 223
None
None
None
None
AW2  A 502 (-3.4A)
1.23A21.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ZJ8_A_SUVA2001_1
(HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE)		4s0v HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE
(Homo
sapiens;
Pyrococcus
abyssi)		11 / 12ALA A 110
VAL A 114
GLN A 134
VAL A 138
GLN A 187
MET A 191
GLU A 212
PHE A 227
ASN A 324
HIS A 350
TYR A 354
SUV  A2001 ( 4.2A)
SUV  A2001 (-4.6A)
SUV  A2001 (-3.5A)
None
SUV  A2001 (-3.6A)
SUV  A2001 ( 4.6A)
SUV  A2001 (-4.1A)
SUV  A2001 ( 4.5A)
SUV  A2001 (-3.0A)
SUV  A2001 ( 3.7A)
None
0.52A83.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJ8_A_SUVA2001_1
(HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE)		5d6b FUMARATE HYDRATASE,
MITOCHONDRIAL
(Homo
sapiens)		5 / 12ALA A 123
VAL A 127
VAL A 106
GLN A 185
PHE A 289
None
1.34A23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJ8_A_SUVA2001_1
(HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE)		5dtr HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC
(Homo
sapiens)		5 / 12ALA A 273
VAL A 293
VAL A 249
MET A 260
PHE A 223
None
1.23A20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJ8_A_SUVA2001_1
(HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE)		5fbh EXTRACELLULAR
CALCIUM-SENSING
RECEPTOR
(Homo
sapiens)		5 / 12ALA B 295
SER B 296
VAL B 269
GLU B 277
PHE B  42
None
1.06A22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJ8_A_SUVA2001_1
(HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE)		5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens)		5 / 12ALA A 158
VAL A 168
GLN A  86
GLU A  90
TYR A 416
None
1.26A22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJ8_A_SUVA2001_1
(HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE)		6b5q DCN1-LIKE PROTEIN 1
(Homo
sapiens)		5 / 12ALA A  98
VAL A 102
GLN A 114
GLU A 121
TYR A 181
None
1.49A8.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJ8_A_SUVA2001_2
(HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE)		1q3x MANNAN-BINDING
LECTIN SERINE
PROTEASE 2
(Homo
sapiens)		4 / 6TRP A 678
ILE A 533
ILE A 497
VAL A 460
None
0.98A20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJ8_A_SUVA2001_2
(HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE)		2ac5 MAP
KINASE-INTERACTING
SERINE/THREONINE
KINASE 2
(Homo
sapiens)		4 / 6TRP A 334
ILE A 345
ILE A 211
VAL A 189
None
0.93A20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJ8_A_SUVA2001_2
(HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE)		2ayn UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 14
(Homo
sapiens)		4 / 6ILE A 169
PRO A 171
HIS A 179
ILE A 151
None
0.98A20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJ8_A_SUVA2001_2
(HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE)		2fei CD2-ASSOCIATED
PROTEIN
(Homo
sapiens)		4 / 6ILE A  11
PRO A  12
ILE A  26
VAL A   6
None
0.91A10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJ8_A_SUVA2001_2
(HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE)		2fei CD2-ASSOCIATED
PROTEIN
(Homo
sapiens)		4 / 6ILE A  11
PRO A  12
ILE A  26
VAL A  53
None
1.01A10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJ8_A_SUVA2001_2
(HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE)		2hw6 MAP
KINASE-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 1
(Homo
sapiens)		4 / 6TRP A 299
ILE A 310
ILE A 176
VAL A 154
None
0.97A20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJ8_A_SUVA2001_2
(HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE)		3tju GRANZYME H
(Homo
sapiens)		4 / 6TRP A 233
ILE A 104
ILE A  65
VAL A  33
None
0.86A17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJ8_A_SUVA2001_2
(HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE)		4fxg MANNAN-BINDING
LECTIN SERINE
PROTEASE 2 B CHAIN
(Homo
sapiens)		4 / 6TRP H 678
ILE H 533
ILE H 497
VAL H 460
None
1.00A19.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ZJ8_A_SUVA2001_2
(HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE)		4s0v HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE
(Homo
sapiens;
Pyrococcus
abyssi)		6 / 6TRP A 120
ILE A 130
PRO A 131
HIS A 224
ILE A 320
VAL A 353
None
SUV  A2001 (-4.8A)
SUV  A2001 (-4.0A)
SUV  A2001 ( 4.8A)
SUV  A2001 (-4.1A)
SUV  A2001 ( 4.9A)
0.38A83.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJ8_A_SUVA2001_2
(HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE)		4x1v CD2-ASSOCIATED
PROTEIN
(Homo
sapiens)		4 / 6ILE A 120
PRO A 121
ILE A 135
VAL A 115
None
0.97A8.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJ8_A_SUVA2001_2
(HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE)		4x8n SET1/ASH2 HISTONE
METHYLTRANSFERASE
COMPLEX SUBUNIT ASH2
(Homo
sapiens)		4 / 6PRO A 470
HIS A 292
ILE A 300
VAL A 307
None
0.97A15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJ8_A_SUVA2001_2
(HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE)		5xdr PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE DHX15
(Homo
sapiens)		4 / 6ILE A 386
PRO A 387
ILE A 336
VAL A 339
None
0.87A21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJ8_A_SUVA2001_2
(HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE)		6ejb XYLOSYLTRANSFERASE 1
(Homo
sapiens)		4 / 6TRP A 555
HIS A 335
ILE A 568
VAL A 569
None
0.87A8.97