POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HAV_A_SRYA403_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		1ul1 FLAP ENDONUCLEASE-1
(Homo
sapiens)		4 / 8ASP X  34
ASP X 179
CYH X 163
TYR X 234
 MG  X1001 (-3.4A)
MG  X1002 ( 4.0A)
None
None
1.14A20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HAV_A_SRYA403_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		2jis CYSTEINE SULFINIC
ACID DECARBOXYLASE
(Homo
sapiens)		4 / 8SER A 472
ASP A 382
ASP A  98
TRP A 369
None
1.18A21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HAV_A_SRYA403_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		2q4k UNCHARACTERIZED
PROTEIN C11ORF68
(Homo
sapiens)		4 / 8ASP A 206
SER A  90
ASP A  33
TRP A  78
None
1.21A21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HAV_A_SRYA403_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		2qqk NEUROPILIN-2
(Homo
sapiens)		4 / 8ASP A  92
SER A 115
ASP A  99
TRP A 212
None
1.27A18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HAV_A_SRYA403_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		2ys3 UNC-112-RELATED
PROTEIN 2
(Homo
sapiens)		4 / 8CYH A  94
ASP A  96
ASP A  13
TYR A 121
None
1.26A18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HAV_A_SRYA403_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		4irq BETA-1,4-GALACTOSYLT
RANSFERASE 7
(Homo
sapiens)		4 / 8ASP A 165
ASP A 163
ASP A 260
TYR A 194
 MN  A 401 ( 2.7A)
UDP  A 402 (-3.3A)
None
UDP  A 402 (-4.6A)
1.12A21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HAV_A_SRYA403_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		4lcy HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-46 ALPHA
CHAIN
(Homo
sapiens)		4 / 8ASP A  74
SER A  77
TRP A 156
TYR A  99
None
1.18A20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HAV_A_SRYA403_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		4zwe DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1
(Homo
sapiens)		4 / 8ASP A 311
SER A 302
ASP A 506
TYR A 374
DGT  A 701 (-2.4A)
None
None
DGT  A 701 (-3.5A)
1.14A20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HAV_A_SRYA403_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		5hn1 INTERLEUKIN-37
(Homo
sapiens)		4 / 8SER A 169
ASP A 191
CYH A 122
ASP A 125
None
1.04A21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HAV_A_SRYA403_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens)		4 / 8ASP A 231
SER A 238
ASP A  48
ASP A  75
None
1.24A16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HAV_A_SRYA403_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		5m4s TRANSCRIPTION
INITIATION FACTOR
IIA SUBUNIT
2,TRANSCRIPTION
INITIATION FACTOR
IIA SUBUNIT
1,TRANSCRIPTION
INITIATION FACTOR
IIA SUBUNIT 1
(Homo
sapiens)		4 / 8ASP A 122
SER A 118
ASP A 126
ASP A 189
None
1.13A14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HAV_A_SRYA403_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		5ufl PROTEIN CIP2A
(Homo
sapiens)		4 / 8SER A 296
ASP A 292
ASP A 246
TYR A 129
None
1.26A19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HAV_C_SRYC403_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		2zb4 PROSTAGLANDIN
REDUCTASE 2
(Homo
sapiens)		5 / 12SER A 140
ASP A 230
CYH A 167
ASP A  49
TYR A 265
None
None
NAP  A 500 (-3.6A)
None
None
1.44A21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DR5_A_SRYA1860_1
(16S RRNA
30S RIBOSOMAL
PROTEIN S12)		1lw3 MYOTUBULARIN-RELATED
PROTEIN 2
(Homo
sapiens)		3 / 3LYS A  74
PRO A  77
LYS A 115
None
1.42A13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DR5_A_SRYA1860_1
(16S RRNA
30S RIBOSOMAL
PROTEIN S12)		4qk3 CARBONIC ANHYDRASE 2
(Homo
sapiens)		3 / 3LYS A  45
PRO A  46
LYS A  80
None
1.42A18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DR6_A_SRYA1956_1
(16S RRNA
30S RIBOSOMAL
PROTEIN S12)		1lw3 MYOTUBULARIN-RELATED
PROTEIN 2
(Homo
sapiens)		3 / 3LYS A  74
PRO A  77
LYS A 115
None
1.49A13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DR6_A_SRYA1956_1
(16S RRNA
30S RIBOSOMAL
PROTEIN S12)		4qk3 CARBONIC ANHYDRASE 2
(Homo
sapiens)		3 / 3LYS A  45
PRO A  46
LYS A  80
None
1.42A18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DR6_A_SRYA1956_1
(16S RRNA
30S RIBOSOMAL
PROTEIN S12)		6ero DIMETHYLADENOSINE
TRANSFERASE 2,
MITOCHONDRIAL,DIMETH
YLADENOSINE
TRANSFERASE 2,
MITOCHONDRIAL
(Homo
sapiens)		3 / 3LYS A  93
PRO A  96
LYS A 103
None
1.46A18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUZ_A_SRYA1601_1
(16S RRNA
RIBOSOMAL PROTEIN
S12)		1eqf RNA POLYMERASE II
TRANSCRIPTION
INITIATION FACTOR
(Homo
sapiens)		3 / 3LYS A1534
PRO A1538
LYS A1419
None
1.48A18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUZ_A_SRYA1601_1
(16S RRNA
RIBOSOMAL PROTEIN
S12)		1t2f L-LACTATE
DEHYDROGENASE B
CHAIN
(Homo
sapiens)		3 / 3LYS A  22
PRO A  19
LYS A  76
None
1.50A18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUZ_A_SRYA1601_1
(16S RRNA
RIBOSOMAL PROTEIN
S12)		2q87 CMRF35-H ANTIGEN
(Homo
sapiens)		3 / 3LYS A  48
PRO A  91
LYS A  30
None
1.45A19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUZ_A_SRYA1601_1
(16S RRNA
RIBOSOMAL PROTEIN
S12)		4qk3 CARBONIC ANHYDRASE 2
(Homo
sapiens)		3 / 3LYS A  45
PRO A  46
LYS A  80
None
1.43A18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUZ_A_SRYA1601_1
(16S RRNA
RIBOSOMAL PROTEIN
S12)		5nyx HEAVY CHAIN
(Homo
sapiens)		3 / 3LYS H  66
PRO H  63
LYS H  60
None
1.08A20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUZ_A_SRYA1601_1
(16S RRNA
RIBOSOMAL PROTEIN
S12)		5vfr 26S PROTEASOME
REGULATORY SUBUNIT
6B
PROTEASOME SUBUNIT
ALPHA TYPE-2
(Homo
sapiens)		3 / 3LYS H 165
PRO H  34
LYS D 418
None
1.49Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DV1_A_SRYA1601_1
(16S RRNA
RIBOSOMAL PROTEIN
S12)		1ad9 IGG CTM01 FAB (LIGHT
CHAIN)
(Homo
sapiens)		3 / 3LYS L  42
LYS L  39
PRO L  40
None
1.11A20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DV1_A_SRYA1601_1
(16S RRNA
RIBOSOMAL PROTEIN
S12)		1p6f NATURAL CYTOTOXICITY
TRIGGERING RECEPTOR
1
(Homo
sapiens)		3 / 3LYS A  20
LYS A  22
PRO A  19
None
1.29A20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DV1_A_SRYA1601_1
(16S RRNA
RIBOSOMAL PROTEIN
S12)		1wb0 CHITOTRIOSIDASE 1
(Homo
sapiens)		3 / 3LYS A  85
LYS A  84
PRO A  88
SO4  A1396 ( 4.0A)
SO4  A1396 (-2.7A)
None
1.28A16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DV1_A_SRYA1601_1
(16S RRNA
RIBOSOMAL PROTEIN
S12)		2dat POSSIBLE GLOBAL
TRANSCRIPTION
ACTIVATOR SNF2L2
(Homo
sapiens)		3 / 3LYS A  16
LYS A  13
PRO A  12
None
1.11A18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DV1_A_SRYA1601_1
(16S RRNA
RIBOSOMAL PROTEIN
S12)		2eqz HIGH MOBILITY GROUP
PROTEIN B3
(Homo
sapiens)		3 / 3LYS A  36
LYS A  35
PRO A  39
None
1.05A21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DV1_A_SRYA1601_1
(16S RRNA
RIBOSOMAL PROTEIN
S12)		2i53 CYCLIN K
(Homo
sapiens)		3 / 3LYS A 112
LYS A 111
PRO A 110
None
1.05A17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DV1_A_SRYA1601_1
(16S RRNA
RIBOSOMAL PROTEIN
S12)		2wfh SLIT HOMOLOG 2
PROTEIN C-PRODUCT
(Homo
sapiens)		3 / 3LYS A 903
LYS A 904
PRO A 901
None
0.98A21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DV1_A_SRYA1601_1
(16S RRNA
RIBOSOMAL PROTEIN
S12)		3bvh FIBRINOGEN GAMMA
CHAIN
(Homo
sapiens)		3 / 3LYS C 151
LYS C 170
PRO C 171
None
1.26A17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DV1_A_SRYA1601_1
(16S RRNA
RIBOSOMAL PROTEIN
S12)		3dvf AMYLOIDOGENIC
IMMUNOGLOBULIN LIGHT
CHAIN PROTEIN AL-12
(Homo
sapiens)		3 / 3LYS A  42
LYS A  39
PRO A  40
None
1.06A18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DV1_A_SRYA1601_1
(16S RRNA
RIBOSOMAL PROTEIN
S12)		3zgq INTERFERON-INDUCED
PROTEIN WITH
TETRATRICOPEPTIDE
REPEATS 5
(Homo
sapiens)		3 / 3LYS A 313
LYS A 309
PRO A 308
None
1.24A15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DV1_A_SRYA1601_1
(16S RRNA
RIBOSOMAL PROTEIN
S12)		4d1e ALPHA-ACTININ-2
(Homo
sapiens)		3 / 3LYS A 205
LYS A 182
PRO A 208
None
MLZ  A 181 ( 3.1A)
MLZ  A 181 ( 4.8A)
1.26A9.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DV1_A_SRYA1601_1
(16S RRNA
RIBOSOMAL PROTEIN
S12)		4nnu TRANSCRIPTION FACTOR
A, MITOCHONDRIAL
(Homo
sapiens)		3 / 3LYS A  52
LYS A  51
PRO A  50
None
1.06A18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DV1_A_SRYA1601_1
(16S RRNA
RIBOSOMAL PROTEIN
S12)		4wxx DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens)		3 / 3LYS A 406
LYS A 440
PRO A 441
None
1.01A7.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DV1_A_SRYA1601_1
(16S RRNA
RIBOSOMAL PROTEIN
S12)		5a1i S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2
(Homo
sapiens)		3 / 3LYS A 368
LYS A 367
PRO A  50
None
1.21A15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DV1_A_SRYA1601_1
(16S RRNA
RIBOSOMAL PROTEIN
S12)		5f72 SINGLE CHAIN FV FROM
A FAB
(Homo
sapiens)		3 / 3LYS T 183
LYS T 180
PRO T 181
None
1.19A17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DV1_A_SRYA1601_1
(16S RRNA
RIBOSOMAL PROTEIN
S12)		5gs3 DIABODY PROTEIN
(Homo
sapiens)		3 / 3LYS H 166
LYS H 163
PRO H 164
None
1.21A19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DV1_A_SRYA1601_1
(16S RRNA
RIBOSOMAL PROTEIN
S12)		5mj3 INTERLEUKIN-12
SUBUNIT BETA
(Homo
sapiens)		3 / 3LYS A 134
LYS A 234
PRO A 235
None
1.28A20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DV1_A_SRYA1601_1
(16S RRNA
RIBOSOMAL PROTEIN
S12)		5ms3 KALLIKREIN-8
(Homo
sapiens)		3 / 3LYS A 166
LYS A 167
PRO A 164
None
1.14A22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DV1_A_SRYA1601_1
(16S RRNA
RIBOSOMAL PROTEIN
S12)		5u03 CTP SYNTHASE 1
(Homo
sapiens)		3 / 3LYS A 193
LYS A 195
PRO A 196
None
0.91A12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DV1_A_SRYA1601_1
(16S RRNA
RIBOSOMAL PROTEIN
S12)		5vni PROTEIN TRANSPORT
PROTEIN SEC23A
(Homo
sapiens)		3 / 3LYS A 758
LYS A 757
PRO A 565
None
1.23A9.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DV1_A_SRYA1601_1
(16S RRNA
RIBOSOMAL PROTEIN
S12)		5wvo DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens)		3 / 3LYS C 406
LYS C 440
PRO C 441
None
1.09A17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DV1_A_SRYA1601_1
(16S RRNA
RIBOSOMAL PROTEIN
S12)		5xjy ATP-BINDING CASSETTE
SUB-FAMILY A MEMBER
1
(Homo
sapiens)		3 / 3LYS A 373
LYS A 376
PRO A 377
None
1.25A4.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DV7_A_SRYA1601_1
(16S RRNA
RIBOSOMAL PROTEIN
S12)		2ev8 55 KDA ERYTHROCYTE
MEMBRANE PROTEIN
(Homo
sapiens)		3 / 3LYS A  76
PRO A  81
LYS A 138
None
1.27A18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DV7_A_SRYA1601_1
(16S RRNA
RIBOSOMAL PROTEIN
S12)		2o13 MUSCLE LIM PROTEIN
(Homo
sapiens)		3 / 3LYS A 119
PRO A 121
LYS A 138
None
1.27A16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DV7_A_SRYA1601_1
(16S RRNA
RIBOSOMAL PROTEIN
S12)		2q87 CMRF35-H ANTIGEN
(Homo
sapiens)		3 / 3LYS A  48
PRO A  91
LYS A  30
None
1.38A19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DV7_A_SRYA1601_1
(16S RRNA
RIBOSOMAL PROTEIN
S12)		4qk3 CARBONIC ANHYDRASE 2
(Homo
sapiens)		3 / 3LYS A  45
PRO A  46
LYS A  80
None
1.35A18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DV7_A_SRYA1601_1
(16S RRNA
RIBOSOMAL PROTEIN
S12)		5vfr 26S PROTEASOME
REGULATORY SUBUNIT
6B
PROTEASOME SUBUNIT
ALPHA TYPE-2
(Homo
sapiens)		3 / 3LYS H 165
PRO H  34
LYS D 418
None
1.44Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DV7_A_SRYA1601_1
(16S RRNA
RIBOSOMAL PROTEIN
S12)		6ero DIMETHYLADENOSINE
TRANSFERASE 2,
MITOCHONDRIAL,DIMETH
YLADENOSINE
TRANSFERASE 2,
MITOCHONDRIAL
(Homo
sapiens)		3 / 3LYS A  93
PRO A  96
LYS A 103
None
1.45A18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DV7_A_SRYA1601_1
(16S RRNA
RIBOSOMAL PROTEIN
S12)		6ero DIMETHYLADENOSINE
TRANSFERASE 2,
MITOCHONDRIAL,DIMETH
YLADENOSINE
TRANSFERASE 2,
MITOCHONDRIAL
(Homo
sapiens)		3 / 3LYS A 103
PRO A 105
LYS A  93
None
1.46A18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJW_A_SRYA2001_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		1elv COMPLEMENT C1S
COMPONENT
(Homo
sapiens)		5 / 12ASN A 600
THR A 651
LEU A 637
ALA A 459
HIS A 496
NES  A2003 (-3.2A)
None
None
None
NES  A2003 (-4.3A)
1.37A16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJW_A_SRYA2001_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		1gvl KALLIKREIN 6
(Homo
sapiens)		5 / 12ASN A 179
THR A 229
LEU A 212
ALA A  56
HIS A  91
None
1.39A20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJW_A_SRYA2001_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		2fej CELLULAR TUMOR
ANTIGEN P53
(Homo
sapiens)		5 / 12ALA A 161
SER A 215
HIS A 214
GLN A 192
ARG A 213
None
1.26A18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJW_A_SRYA2001_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		2uzp PROTEIN KINASE C
GAMMA TYPE
(Homo
sapiens)		5 / 12ASN A 206
THR A 208
LEU A 200
GLU A 284
ARG A 238
None
1.47A19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJW_A_SRYA2001_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		3f6u VITAMIN K-DEPENDENT
PROTEIN C HEAVY
CHAIN
(Homo
sapiens)		5 / 12ASN H 179
THR H 229
LEU H 212
ALA H  56
HIS H  91
None
1.33A20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJW_A_SRYA2001_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		3thw DNA MISMATCH REPAIR
PROTEIN MSH3
(Homo
sapiens)		5 / 12LEU B 585
ALA B 587
SER B 589
TYR B 912
ARG B 839
None
1.34A12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJW_A_SRYA2001_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		5ubm COMPLEMENT C1S
SUBCOMPONENT
(Homo
sapiens)		5 / 12ASN A 615
THR A 666
LEU A 652
ALA A 474
HIS A 511
None
1.38A19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJW_A_SRYA2001_2
(TRANSCRIPTIONAL
REGULATOR TCAR)		2wim NEURAL CELL ADHESION
MOLECULE 2
(Homo
sapiens)		4 / 6GLU A  86
ILE A  85
ASN A  84
VAL A 107
None
1.04A22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJW_A_SRYA2001_2
(TRANSCRIPTIONAL
REGULATOR TCAR)		3cxl N-CHIMERIN
(Homo
sapiens)		4 / 6GLU A 291
ILE A 292
GLU A 410
HIS A 407
None
1.09A16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJW_A_SRYA2001_2
(TRANSCRIPTIONAL
REGULATOR TCAR)		3dxb THIOREDOXIN
N-TERMINALLY FUSED
TO PUF60(UHM)
(Escherichia
coli;
Homo
sapiens)		4 / 6GLU A 542
ILE A 526
ASN A 530
GLU A 483
None
0.99A23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJW_A_SRYA2001_2
(TRANSCRIPTIONAL
REGULATOR TCAR)		4jxf SERINE/THREONINE-PRO
TEIN KINASE PLK4
(Homo
sapiens)		4 / 6GLU A  96
ASN A 141
GLU A  60
HIS A  64
None
EDO  A 302 ( 4.3A)
None
None
1.02A20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJW_A_SRYA2001_2
(TRANSCRIPTIONAL
REGULATOR TCAR)		4wo4 ANTIGEN-PRESENTING
GLYCOPROTEIN CD1D
(Homo
sapiens)		4 / 6GLU A 132
ILE A 145
ASN A 149
VAL A  98
None
1.13A19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJW_A_SRYA2001_2
(TRANSCRIPTIONAL
REGULATOR TCAR)		5c5b DCC-INTERACTING
PROTEIN 13-ALPHA
DCC-INTERACTING
PROTEIN 13-BETA
(Homo
sapiens)		4 / 6GLU B 102
ASN B 209
HIS A 100
VAL B  47
None
0.89A20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JI8_A_SRYA1601_1
(16S RRNA
RIBOSOMAL PROTEIN
S12)		4kmz FOLATE RECEPTOR BETA
(Homo
sapiens)		3 / 3LYS A  91
LYS A  85
TRP A  80
None
1.26A19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JI8_A_SRYA1601_1
(16S RRNA
RIBOSOMAL PROTEIN
S12)		4roj GUANINE NUCLEOTIDE
EXCHANGE FACTOR VAV2
(Homo
sapiens)		3 / 3LYS A 736
LYS A 725
TRP A 728
None
1.41A19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LUH_A_SRYA304_1
(STREPTOMYCIN
3''-ADENYLYLTRANSFER
ASE)		5d3q DYNAMIN-1,DYNAMIN-1
(Homo
sapiens)		5 / 10ASP A 194
ASP A  30
HIS A 288
ILE A 289
THR A 292
None
0.96A13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LUH_B_SRYB303_1
(STREPTOMYCIN
3''-ADENYLYLTRANSFER
ASE)		5d3q DYNAMIN-1,DYNAMIN-1
(Homo
sapiens)		5 / 10ASP A 194
ASP A  30
HIS A 288
ILE A 289
THR A 292
None
0.97A13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FZB_B_SRYB301_1
(STREPTOMYCIN
3''-ADENYLYLTRANSFER
ASE)		2mbb IMMUNOGLOBULIN
G-BINDING PROTEIN
G/DNA POLYMERASE
IOTA FUSION PROTEIN
POLYUBIQUITIN-B
(Homo
sapiens;
Streptococcus
sp.
'group
G')		5 / 12GLU A  73
GLN A  72
ASP A  81
HIS B 268
ILE B 244
None
1.45A19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FZB_B_SRYB301_1
(STREPTOMYCIN
3''-ADENYLYLTRANSFER
ASE)		5fqd CASEIN KINASE I
ISOFORM ALPHA
(Homo
sapiens)		5 / 12GLN C 198
ASP C 203
ASP C 140
ASP C 157
ILE C 156
None
1.37A11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FZB_B_SRYB301_1
(STREPTOMYCIN
3''-ADENYLYLTRANSFER
ASE)		5okt CASEIN KINASE I
ISOFORM DELTA
(Homo
sapiens)		5 / 12GLN C 190
ASP C 195
ASP C 132
ASP C 149
ILE C 148
GOL  C 309 (-2.9A)
GOL  C 309 (-3.6A)
None
None
9XK  C 301 ( 3.6A)
1.43A19.05