POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		1yse DNA-BINDING PROTEIN
SATB1
(Homo
sapiens)		5 / 12LEU A 405
TYR A 376
ALA A 397
PHE A 393
LEU A 433
None
1.13A12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		2j0u ATP-DEPENDENT RNA
HELICASE DDX48
(Homo
sapiens)		5 / 12LEU A 184
LEU A 110
ALA A 161
ASP A 187
THR A  89
None
1.29A20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		2o49 DNA-BINDING PROTEIN
SATB1
(Homo
sapiens)		5 / 12LEU A 405
TYR A 376
ALA A 397
PHE A 393
LEU A 433
None
1.19A11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		3j0a TOLL-LIKE RECEPTOR 5
(Homo
sapiens)		5 / 12LEU A 504
LEU A 507
ALA A 488
LEU A 517
THR A 539
None
1.20A20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		4iul EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4
GAMMA 2
(Homo
sapiens)		5 / 12LEU A 116
LEU A 117
PHE A  78
LEU A 109
THR A 162
None
1.25A20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		4knw N-ACYLNEURAMINATE-9-
PHOSPHATASE
(Homo
sapiens)		5 / 12LEU A 178
LEU A 179
GLN A 182
TYR A 174
PHE A  12
None
1.27A19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		4n78 CYTOPLASMIC
FMR1-INTERACTING
PROTEIN 1
(Homo
sapiens)		5 / 12LEU A 393
PHE A 608
PHE A 359
LEU A 461
THR A 611
None
1.29A17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		4z3k SEPIAPTERIN
REDUCTASE
(Homo
sapiens)		5 / 12LEU A  27
LEU A   2
GLN A  90
ALA A   5
LEU A  58
None
1.31A20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		5dqs ELONGATION FACTOR
1-GAMMA
(Homo
sapiens)		5 / 12LEU A   6
GLN A  28
ALA A   2
ASP A  65
ASP A  64
None
1.00A19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		5ebb ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Homo
sapiens)		5 / 12LEU A 139
GLN A 137
TYR A  85
PHE A  92
LEU A  46
None
None
NAG  A 704 (-4.0A)
None
None
1.29A21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		5of4 TFIIH BASAL
TRANSCRIPTION FACTOR
COMPLEX HELICASE XPD
SUBUNIT
(Homo
sapiens)		5 / 12LEU B 107
LEU B 105
ALA B 172
LEU B 183
ASP B 179
None
1.19A22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		5van BETA-KLOTHO
(Homo
sapiens)		5 / 12LEU A 178
LEU A 179
TYR A 174
PHE A 229
LEU A 158
None
1.15A10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		5wwt PUTATIVE
METHYLTRANSFERASE
NSUN6
(Homo
sapiens)		5 / 12LEU A 225
PHE A 458
LEU A 321
ASP A 240
ASP A 323
None
C  C  72 ( 4.4A)
None
None
C  C  72 ( 2.8A)
1.19A23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		1n76 LACTOFERRIN
(Homo
sapiens)		5 / 9VAL A 542
ALA A 543
GLY A 455
SER A 492
GLY A 540
None
1.27A21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		1tki TITIN
(Homo
sapiens)		5 / 9ASP A 144
VAL A 191
ALA A 188
TYR A 187
GLY A 141
None
1.30A19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		1y0l CATALYTIC ANTIBODY
FAB 34E4 HEAVY CHAIN
(Homo
sapiens;
Mus
musculus)		5 / 9PRO H  14
VAL H 111
ALA H  12
SER H  82
GLY H  16
None
1.18A18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		2yun NOSTRIN
(Homo
sapiens)		5 / 9PRO A  55
VAL A  59
ALA A  57
PHE A  54
GLY A  41
None
1.32A10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		3fd5 SELENIDE, WATER
DIKINASE 1
(Homo
sapiens)		5 / 9VAL A 302
ALA A 305
GLY A  28
PHE A 310
GLY A 307
None
1.19A20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		4rkk LAFORIN
(Homo
sapiens)		5 / 9PRO A 246
VAL A 249
ALA A 248
GLY A 322
PHE A 317
None
1.15A19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		5epg ALDEHYDE OXIDASE
(Homo
sapiens)		5 / 9ASP A1093
VAL A1163
TYR A1161
SER A1265
GLY A1192
None
1.14A17.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MM5_A_SREA603_1
(TRANSPORTER)		5i6z SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER
(Homo
sapiens)		6 / 9ASP A  98
ALA A 173
TYR A 176
GLY A 338
SER A 438
GLY A 442
None
0.73A32.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		5k1c WD REPEAT-CONTAINING
PROTEIN 20
(Homo
sapiens)		5 / 9ASP C 382
VAL C 288
ALA C 298
GLY C 370
GLY C 300
None
1.29A21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		1hzf COMPLEMENT FACTOR
C4A
(Homo
sapiens)		5 / 9ALA A1005
TYR A1008
GLY A1274
PHE A1280
SER A 977
None
0.97A21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		1n76 LACTOFERRIN
(Homo
sapiens)		5 / 9VAL A 542
ALA A 543
GLY A 455
SER A 492
GLY A 540
None
1.25A21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		1tki TITIN
(Homo
sapiens)		5 / 9ASP A 144
VAL A 191
ALA A 188
TYR A 187
GLY A 141
None
1.31A19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		1y0l CATALYTIC ANTIBODY
FAB 34E4 HEAVY CHAIN
(Homo
sapiens;
Mus
musculus)		5 / 9PRO H  14
VAL H 111
ALA H  12
SER H  82
GLY H  16
None
1.18A18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		2kt1 PHOSPHATIDYLINOSITOL
3-KINASE REGULATORY
SUBUNIT BETA
(Homo
sapiens)		5 / 9ASP A  69
PRO A  51
VAL A  54
GLY A  59
GLY A  72
None
1.13A10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		2wzo TRANSFORMING GROWTH
FACTOR BETA
REGULATOR 1
(Homo
sapiens)		5 / 9ASP A 201
PRO A 213
VAL A 214
GLY A 204
PHE A 205
None
1.32A13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		3fd5 SELENIDE, WATER
DIKINASE 1
(Homo
sapiens)		5 / 9VAL A 302
ALA A 305
GLY A  28
PHE A 310
GLY A 307
None
1.22A20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		4rkk LAFORIN
(Homo
sapiens)		5 / 9PRO A 246
VAL A 249
ALA A 248
GLY A 322
PHE A 317
None
1.27A20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		5epg ALDEHYDE OXIDASE
(Homo
sapiens)		5 / 9ASP A1093
VAL A1163
TYR A1161
SER A1265
GLY A1192
None
1.08A18.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MMB_A_SREA603_1
(TRANSPORTER)		5i6z SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER
(Homo
sapiens)		6 / 9ASP A  98
ALA A 173
TYR A 176
GLY A 338
SER A 438
GLY A 442
None
0.78A31.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		5k1c WD REPEAT-CONTAINING
PROTEIN 20
(Homo
sapiens)		5 / 9ASP C 382
VAL C 288
ALA C 298
GLY C 370
GLY C 300
None
1.28A21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		5yy8 INFLUENZA VIRUS
NS1A-BINDING PROTEIN
(Homo
sapiens)		5 / 9ASP A 115
PRO A  90
GLY A 108
SER A 113
GLY A 111
None
1.34A8.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		6f39 COMPLEMENT C1R
SUBCOMPONENT
(Homo
sapiens)		5 / 9ASP A 226
TYR A 197
GLY A 252
PHE A 223
SER A 278
 CA  A 303 (-3.2A)
None
None
None
CA  A 303 ( 3.8A)
1.14A9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWO_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		1glo CATHEPSIN S
(Homo
sapiens)		5 / 9ASP A  87
ALA A  30
PHE A  28
SER A  47
GLY A  32
None
1.36A17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWO_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		1t0p INTEGRIN ALPHA-L
(Homo
sapiens)		5 / 9ASP A 249
ALA A 211
ILE A 212
GLY A 246
PHE A 209
None
1.34A15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWO_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		1um7 SYNAPSE-ASSOCIATED
PROTEIN 102
(Homo
sapiens)		5 / 9ALA A  95
ILE A  64
GLY A  29
PHE A  30
SER A  44
None
1.24A12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWO_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		3zkj ANKYRIN REPEAT AND
SOCS BOX PROTEIN 9
(Homo
sapiens)		5 / 9ASP A 161
ALA A 155
ILE A 154
GLY A 271
GLY A 157
None
1.16A17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWO_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		5e6s INTEGRIN ALPHA-L
(Homo
sapiens)		5 / 9ASP A 249
ALA A 211
ILE A 212
GLY A 246
PHE A 209
None
1.22A20.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AWO_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		5i6z SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER
(Homo
sapiens)		8 / 9TYR A  95
ASP A  98
ALA A 169
ILE A 172
PHE A 335
GLY A 338
SER A 438
GLY A 442
None
0.49A99.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWO_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		5lf7 PROTEASOME SUBUNIT
BETA TYPE-1
(Homo
sapiens)		5 / 9ASP L 169
ALA L  21
ILE L  22
SER L 167
GLY L  17
None
1.34A18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWO_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		5u6b TYROSINE-PROTEIN
KINASE RECEPTOR UFO
(Homo
sapiens)		5 / 9ASP A 731
ALA A 675
PHE A 691
GLY A 692
SER A 734
None
1.25A20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWQ_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		1glo CATHEPSIN S
(Homo
sapiens)		5 / 9ASP A  87
ALA A  30
PHE A  28
SER A  47
GLY A  32
None
1.36A17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWQ_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		1t0p INTEGRIN ALPHA-L
(Homo
sapiens)		5 / 9ASP A 249
ALA A 211
ILE A 212
GLY A 246
PHE A 209
None
1.35A15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWQ_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		1um7 SYNAPSE-ASSOCIATED
PROTEIN 102
(Homo
sapiens)		5 / 9ALA A  95
ILE A  64
GLY A  29
PHE A  30
SER A  44
None
1.25A12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWQ_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		3zkj ANKYRIN REPEAT AND
SOCS BOX PROTEIN 9
(Homo
sapiens)		5 / 9ASP A 161
ALA A 155
ILE A 154
GLY A 271
GLY A 157
None
1.17A17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWQ_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		5e6s INTEGRIN ALPHA-L
(Homo
sapiens)		5 / 9ASP A 249
ALA A 211
ILE A 212
GLY A 246
PHE A 209
None
1.22A20.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AWQ_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		5i6z SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER
(Homo
sapiens)		8 / 9TYR A  95
ASP A  98
ALA A 169
ILE A 172
PHE A 335
GLY A 338
SER A 438
GLY A 442
None
0.48A99.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWQ_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		5lf7 PROTEASOME SUBUNIT
BETA TYPE-1
(Homo
sapiens)		5 / 9ASP L 169
ALA L  21
ILE L  22
SER L 167
GLY L  17
None
1.34A18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWQ_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		5u6b TYROSINE-PROTEIN
KINASE RECEPTOR UFO
(Homo
sapiens)		5 / 9ASP A 731
ALA A 675
PHE A 691
GLY A 692
SER A 734
None
1.26A20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		1yzx GLUTATHIONE
S-TRANSFERASE KAPPA
1
(Homo
sapiens)		5 / 10ILE A  32
ARG A   6
VAL A   8
ALA A 188
LEU A  26
None
0.88A17.94
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		2d9j REGULATOR OF
G-PROTEIN SIGNALLING
7
(Homo
sapiens)		5 / 10ARG A  29
ALA A  22
LEU A  49
MET A 115
LEU A  36
None
1.03A17.04
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		2wnt RIBOSOMAL PROTEIN S6
KINASE
(Homo
sapiens)		6 / 10ILE A 555
ALA A 512
LEU A 497
LEU A 553
LEU A 536
LEU A 603
None
1.42A14.62
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		3eto NEUROGENIC LOCUS
NOTCH HOMOLOG
PROTEIN 1
(Homo
sapiens)		5 / 10ILE A1715
VAL A1700
ALA A1697
LEU A1704
LEU A1601
None
1.04A14.23
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		3hzj RAB
GTPASE-ACTIVATING
PROTEIN 1-LIKE
(Homo
sapiens)		5 / 10VAL A 535
LEU A 531
LEU A 516
LEU A 550
LEU A 551
None
0.99A15.33
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		3sqo PCSK9 PRODOMAIN
(Homo
sapiens)		5 / 10ARG P  97
LEU P  98
LEU P 137
LEU P 131
LEU P 130
None
1.03A20.17
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		3uk6 RUVB-LIKE 2
(Homo
sapiens)		5 / 10ILE A 346
ALA A 122
LEU A 312
LEU A 304
LEU A 324
None
0.96A12.50
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		4da1 PROTEIN PHOSPHATASE
1K, MITOCHONDRIAL
(Homo
sapiens)		5 / 10VAL A 120
LEU A 156
TYR A 122
LEU A 149
LEU A 150
None
1.04A12.78
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		4nc6 RAB
GTPASE-ACTIVATING
PROTEIN 1
(Homo
sapiens)		5 / 10VAL A 563
LEU A 559
LEU A 544
LEU A 578
LEU A 579
None
0.95A13.42
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		5w0m TERMINAL
URIDYLYLTRANSFERASE
7
(Homo
sapiens)		5 / 10ILE A1120
ALA A1021
LEU A1059
LEU A1042
LEU A1044
None
1.02A17.75
10.03