POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5IGZ_A_SPRA404_2 (MACROLIDE 2'-PHOSPHOTRANSFERAS E II)	1bkd	SON OF SEVENLESS-1 (Homo sapiens)	5 / 9	LEU S 788 HIS S 827 ILE S 855 GLU S 857 VAL S 861	None	0.70A	19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5IGZ_A_SPRA404_2 (MACROLIDE 2'-PHOSPHOTRANSFERAS E II)	1xdv	SON OF SEVENLESS PROTEIN HOMOLOG 1 (Homo sapiens)	5 / 9	LEU A 788 HIS A 827 ILE A 855 GLU A 857 VAL A 861	None	0.70A	14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5IGZ_A_SPRA404_2 (MACROLIDE 2'-PHOSPHOTRANSFERAS E II)	2iu1	EUKARYOTIC TRANSLATION INITIATION FACTOR 5 (Homo sapiens)	5 / 9	LEU A 314 ILE A 293 ILE A 351 GLU A 349 GLU A 319	None	1.20A	20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5IGZ_A_SPRA404_2 (MACROLIDE 2'-PHOSPHOTRANSFERAS E II)	2oxc	PROBABLE ATP-DEPENDENT RNA HELICASE DDX20 (Homo sapiens)	5 / 9	LEU A 250 ILE A 103 ILE A 226 GLU A 224 GLU A 212	None	1.11A	21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5IGZ_A_SPRA404_2 (MACROLIDE 2'-PHOSPHOTRANSFERAS E II)	2rop	COPPER-TRANSPORTING ATPASE 2 (Homo sapiens)	5 / 9	LEU A  24 ILE A  42 GLU A  39 VAL A  35 GLU A  79	None	1.21A	21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5IGZ_A_SPRA404_2 (MACROLIDE 2'-PHOSPHOTRANSFERAS E II)	2vkt	CTP SYNTHASE 2 (Homo sapiens)	5 / 9	ILE A 337 ILE A 393 PHE A 395 VAL A 521 GLU A 408	None	1.48A	21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5IGZ_A_SPRA404_2 (MACROLIDE 2'-PHOSPHOTRANSFERAS E II)	2y6e	UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 4 (Homo sapiens)	5 / 9	LEU A 320 ILE A 359 ILE A 868 PHE A 919 VAL A 917	None	1.41A	21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5IGZ_A_SPRA404_2 (MACROLIDE 2'-PHOSPHOTRANSFERAS E II)	3e9l	PRE-MRNA-PROCESSING- SPLICING FACTOR 8 (Homo sapiens)	5 / 9	LEU A1817 ILE A1809 ILE A1906 PHE A1902 VAL A1899	None	1.41A	22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5IGZ_A_SPRA404_2 (MACROLIDE 2'-PHOSPHOTRANSFERAS E II)	3fs1	HEPATOCYTE NUCLEAR FACTOR 4-ALPHA (Homo sapiens)	5 / 9	LEU A 211 ILE A 196 GLU A 201 PHE A 199 GLU A 191	None	1.18A	23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5IGZ_A_SPRA404_2 (MACROLIDE 2'-PHOSPHOTRANSFERAS E II)	3ksy	SON OF SEVENLESS HOMOLOG 1 (Homo sapiens)	5 / 9	LEU A 788 HIS A 827 ILE A 855 GLU A 857 VAL A 861	None	0.88A	13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5IGZ_A_SPRA404_2 (MACROLIDE 2'-PHOSPHOTRANSFERAS E II)	3tg1	DUAL SPECIFICITY PROTEIN PHOSPHATASE 10 (Homo sapiens)	5 / 9	LEU B 256 ILE B 175 ILE B 149 GLU B 242 GLU B 265	None	1.33A	18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5IGZ_A_SPRA404_2 (MACROLIDE 2'-PHOSPHOTRANSFERAS E II)	4f92	U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 200 KDA HELICASE (Homo sapiens)	5 / 9	LEU B 876 HIS B 421 ILE B 870 GLU B 444 VAL B 445	None	1.45A	10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5IGZ_A_SPRA404_2 (MACROLIDE 2'-PHOSPHOTRANSFERAS E II)	4grl	MHC CLASS II HLA-DQ-ALPHA CHAIN (Homo sapiens)	5 / 9	LEU A  12 ILE A 112 GLU A  85 PHE A 145 GLU A  25	None	1.50A	18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5IGZ_A_SPRA404_2 (MACROLIDE 2'-PHOSPHOTRANSFERAS E II)	4j5a	PEPTIDYL-PROLYL CIS-TRANS ISOMERASE F, MITOCHONDRIAL (Homo sapiens)	5 / 9	LEU X 140 ARG X  79 GLU X 128 PHE X 171 VAL X 169	None	1.50A	19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5IGZ_A_SPRA404_2 (MACROLIDE 2'-PHOSPHOTRANSFERAS E II)	4s15	NUCLEAR RECEPTOR ROR-ALPHA (Homo sapiens)	5 / 9	LEU A 356 ILE A 341 GLU A 346 PHE A 344 GLU A 336	None	1.39A	21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5IGZ_A_SPRA404_2 (MACROLIDE 2'-PHOSPHOTRANSFERAS E II)	4ydh	FORMIN-LIKE PROTEIN 1 (Homo sapiens)	5 / 9	LEU A 261 GLU A 298 PHE A 296 VAL A 299 GLU A 311	None	1.21A	22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5IGZ_A_SPRA404_2 (MACROLIDE 2'-PHOSPHOTRANSFERAS E II)	5avi	OXYSTEROLS RECEPTOR LXR-ALPHA (Homo sapiens)	5 / 9	LEU A 414 ILE A 339 GLU A 341 PHE A 342 GLU A 301	None 4KM  A 501 ( 4.0A) None None None	1.49A	21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5IGZ_A_SPRA404_2 (MACROLIDE 2'-PHOSPHOTRANSFERAS E II)	5o1p	ALPHA-AMINOADIPIC SEMIALDEHYDE SYNTHASE, MITOCHONDRIAL (Homo sapiens)	5 / 9	HIS A 853 ILE A 616 GLU A 621 VAL A 622 GLU A 627	None	1.39A	20.87