POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1KLM_A_SPPA999_1 (HIV-1 REVERSE TRANSCRIPTASE)	2gjx	BETA-HEXOSAMINIDASE ALPHA CHAIN (Homo sapiens)	5 / 11	LEU A 172 VAL A 192 PRO A 471 LEU A 473 PRO A 475	None	1.21A	21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1KLM_A_SPPA999_1 (HIV-1 REVERSE TRANSCRIPTASE)	2gk1	BETA-HEXOSAMINIDASE SUBUNIT ALPHA (Homo sapiens)	5 / 11	LEU I 172 VAL I 192 PRO I 471 LEU I 473 PRO I 475	None	1.22A	22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1KLM_A_SPPA999_1 (HIV-1 REVERSE TRANSCRIPTASE)	2o8e	DNA MISMATCH REPAIR PROTEIN MSH6 (Homo sapiens)	5 / 11	LEU B 887 LYS B 883 VAL B 878 PRO B 802 LEU B 798	None	1.20A	20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1KLM_A_SPPA999_1 (HIV-1 REVERSE TRANSCRIPTASE)	2p82	CYSTEINE PROTEASE ATG4A (Homo sapiens)	5 / 11	LEU A  79 TYR A  57 PRO A 261 TRP A  75 PRO A 148	None	1.46A	21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1KLM_A_SPPA999_1 (HIV-1 REVERSE TRANSCRIPTASE)	2q6z	UROPORPHYRINOGEN DECARBOXYLASE (Homo sapiens)	5 / 11	LEU A 181 PRO A 226 TRP A 159 LEU A 228 TYR A 182	None	1.45A	20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1KLM_A_SPPA999_1 (HIV-1 REVERSE TRANSCRIPTASE)	3un9	NLR FAMILY MEMBER X1 (Homo sapiens)	5 / 11	LEU A 770 LYS A 768 PRO A 790 LEU A 762 PRO A 764	None	1.25A	21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1KLM_A_SPPA999_1 (HIV-1 REVERSE TRANSCRIPTASE)	4asi	ACETYL-COA CARBOXYLASE 1 (Homo sapiens)	5 / 11	VAL A2022 TYR A2118 PHE A1992 LEU A2015 PRO A2019	None	1.46A	21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1KLM_A_SPPA999_1 (HIV-1 REVERSE TRANSCRIPTASE)	4epu	ANGIOPOIETIN-1 (Homo sapiens)	5 / 11	LEU A 373 PRO A 454 TRP A 448 LEU A 418 TYR A 389	None	1.40A	14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1KLM_A_SPPA999_1 (HIV-1 REVERSE TRANSCRIPTASE)	4fdd	TRANSPORTIN-1 (Homo sapiens)	5 / 11	LEU A 293 VAL A 389 TRP A 280 LEU A 283 PRO A 287	None	1.23A	19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1KLM_A_SPPA999_1 (HIV-1 REVERSE TRANSCRIPTASE)	4fm9	DNA TOPOISOMERASE 2-ALPHA (Homo sapiens)	5 / 11	LEU A 730 LYS A 728 PRO A 716 LEU A 722 PRO A 724	None	1.38A	22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1KLM_A_SPPA999_1 (HIV-1 REVERSE TRANSCRIPTASE)	4mzv	EPITHELIAL CELL ADHESION MOLECULE (Homo sapiens)	5 / 11	LEU A 166 LYS A 168 TYR A 186 TYR A 157 LEU A 233	None None None None DMU  A 301 ( 4.6A)	1.48A	18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1KLM_A_SPPA999_1 (HIV-1 REVERSE TRANSCRIPTASE)	4r3i	YTH DOMAIN-CONTAINING PROTEIN 1 (Homo sapiens)	5 / 11	LEU A 461 PRO A 493 PHE A 492 LEU A 491 PRO A 454	None	1.25A	13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1KLM_A_SPPA999_1 (HIV-1 REVERSE TRANSCRIPTASE)	5b16	RIBONUCLEASE 3,DROSHA,RIBONUCLEAS E 3,DROSHA,RIBONUCLEAS E 3 (Homo sapiens)	5 / 11	LEU A1162 PHE A1252 LEU A1249 PRO A1247 TYR A1161	None	1.32A	17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1KLM_A_SPPA999_1 (HIV-1 REVERSE TRANSCRIPTASE)	5i2c	GATS-LIKE PROTEIN 3 (Homo sapiens)	5 / 11	VAL A  71 PHE A  60 LEU A  63 PRO A  65 TYR A  23	None	1.23A	19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1KLM_A_SPPA999_1 (HIV-1 REVERSE TRANSCRIPTASE)	5mra	SORCIN (Homo sapiens)	5 / 11	LEU A 129 LYS A 127 VAL A 120 TYR A 148 PHE A 109	None	1.08A	16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1KLM_A_SPPA999_1 (HIV-1 REVERSE TRANSCRIPTASE)	6fyo	DUAL SPECIFICITY PROTEIN KINASE CLK1 (Homo sapiens)	5 / 11	LEU A 458 VAL A 378 PRO A 435 PHE A 439 LEU A 436	None	1.39A	undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1KLM_A_SPPA999_1 (HIV-1 REVERSE TRANSCRIPTASE)	6fyv	DUAL SPECIFICITY PROTEIN KINASE CLK4 (Homo sapiens)	5 / 11	LEU A 458 VAL A 378 PRO A 435 PHE A 439 LEU A 436	None	1.41A	undetectable