POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2J1G_F_SC2F1290_1
(FICOLIN-2)		2d39 FICOLIN-1
(Homo
sapiens)		8 / 10SER A 129
LEU A 145
ASP A 147
ASP A 149
THR A 150
ARG A 160
GLU A 320
LYS A 322
None
0.42A81.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2J1G_F_SC2F1290_1
(FICOLIN-2)		2j64 FICOLIN-3
(Homo
sapiens)		5 / 10SER A  26
ASP A  44
ASP A  46
THR A  47
ARG A  57
None
0.98A51.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2J1G_F_SC2F1290_1
(FICOLIN-2)		2wnp FICOLIN-1
(Homo
sapiens)		8 / 10SER F 100
LEU F 116
ASP F 118
ASP F 120
THR F 121
ARG F 131
GLU F 291
LYS F 293
None
0.55A83.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2J1G_F_SC2F1290_1
(FICOLIN-2)		4m7f FIBRINOGEN C
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens)		5 / 10ASP A 274
THR A 277
ARG A 287
GLU A 451
LYS A 453
None
1.26A50.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2J1G_F_SC2F1290_1
(FICOLIN-2)		4r9j FICOLIN-2
(Homo
sapiens)		8 / 10SER G  91
LEU G 107
ASP G 109
ASP G 111
THR G 112
ARG G 122
GLU G 282
LYS G 284
None
0.29A99.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_A_SC2A1290_1
(FICOLIN-2)		1aye PROCARBOXYPEPTIDASE
A2
(Homo
sapiens)		4 / 5SER A 197
LEU A 280
GLY A 278
ARG A 124
None
0.97A19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_A_SC2A1290_1
(FICOLIN-2)		1dtd CARBOXYPEPTIDASE A2
(Homo
sapiens)		4 / 5SER A 553
LEU A 636
GLY A 634
ARG A 479
None
0.95A19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_A_SC2A1290_1
(FICOLIN-2)		1kwm PROCARBOXYPEPTIDASE
B
(Homo
sapiens)		4 / 5SER A 197
LEU A 280
GLY A 278
ARG A 124
None
0.92A19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_A_SC2A1290_1
(FICOLIN-2)		1zli CARBOXYPEPTIDASE B
(Homo
sapiens)		4 / 5SER A 197
LEU A 280
GLY A 278
ARG A 124
None
0.96A23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_A_SC2A1290_1
(FICOLIN-2)		2boa CARBOXYPEPTIDASE A4
(Homo
sapiens)		4 / 5SER A1197
LEU A1280
GLY A1278
ARG A1124
None
0.93A19.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2J2P_A_SC2A1290_1
(FICOLIN-2)		2d39 FICOLIN-1
(Homo
sapiens)		4 / 5ASP A 163
SER A 165
LEU A 183
GLY A 184
None
0.19A81.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_A_SC2A1290_1
(FICOLIN-2)		2oq1 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens)		4 / 5ASP A   5
LEU A  45
GLY A  46
ARG A 121
None
1.17A19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_A_SC2A1290_1
(FICOLIN-2)		2pcu CARBOXYPEPTIDASE A4
(Homo
sapiens)		4 / 5SER A 197
LEU A 280
GLY A 278
ARG A 124
None
GOL  A 501 (-4.4A)
None
GOL  A 501 (-4.0A)
0.93A21.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2J2P_A_SC2A1290_1
(FICOLIN-2)		2wnp FICOLIN-1
(Homo
sapiens)		4 / 5ASP F 134
SER F 136
LEU F 154
GLY F 155
None
0.30A83.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_A_SC2A1290_1
(FICOLIN-2)		3e4c CASPASE-1
(Homo
sapiens)		4 / 5ASP A 185
SER A 347
LEU A 353
GLY A 351
None
1.20A22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_A_SC2A1290_1
(FICOLIN-2)		3fju CARBOXYPEPTIDASE A1
(Homo
sapiens)		4 / 5SER A 197
LEU A 280
GLY A 278
ARG A 124
None
0.98A18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_A_SC2A1290_1
(FICOLIN-2)		3lms CARBOXYPEPTIDASE B2
(Homo
sapiens)		4 / 5SER A 197
LEU A 280
GLY A 278
ARG A 124
None
GOL  A 505 (-4.6A)
None
GOL  A 505 (-3.9A)
0.97A21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_A_SC2A1290_1
(FICOLIN-2)		3r7s CASPASE-2 SUBUNIT
P18
(Homo
sapiens)		4 / 5ASP A 268
SER A 196
LEU A 201
GLY A 200
None
1.18A21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_A_SC2A1290_1
(FICOLIN-2)		4deq NEUROPILIN-1,
VASCULAR ENDOTHELIAL
GROWTH FACTOR A
(Homo
sapiens)		4 / 5ASP A 158
SER A 160
LEU A 126
GLY A 163
None
1.12A20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_A_SC2A1290_1
(FICOLIN-2)		4gwn MEPRIN A SUBUNIT
BETA
(Homo
sapiens)		4 / 5ASP A 353
SER A 316
LEU A 412
GLY A 413
None
1.21A17.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2J2P_A_SC2A1290_1
(FICOLIN-2)		4r9j FICOLIN-2
(Homo
sapiens)		4 / 5ASP G 125
SER G 127
LEU G 145
GLY G 146
None
0.45A99.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_A_SC2A1290_1
(FICOLIN-2)		4uf4 CARBOXYPEPTIDASE A1
(Homo
sapiens)		4 / 5SER A 307
LEU A 390
GLY A 388
ARG A 234
None
0.94A19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_A_SC2A1290_1
(FICOLIN-2)		4yk6 ADENOMATOUS
POLYPOSIS COLI
PROTEIN
(Homo
sapiens)		4 / 5ASP A 482
SER A 494
LEU A 488
GLY A 487
None
0.98A19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_A_SC2A1290_1
(FICOLIN-2)		4z79 LEIOMODIN-1
ACTIN-BINDING SITE 2
(ABS2)
(Homo
sapiens)		4 / 5ASP A 373
LEU A 405
GLY A 401
ARG A 409
None
None
None
CL  A 507 (-4.1A)
1.22A19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_A_SC2A1290_1
(FICOLIN-2)		4z94 GELSOLIN,
TROPOMODULIN-1,
LEIOMODIN-1 CHIMERA
(Homo
sapiens)		4 / 5ASP G1373
LEU G1405
GLY G1401
ARG G1409
None
1.14A21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_A_SC2A1290_1
(FICOLIN-2)		5a31 THE
ANAPHASE-PROMOTING
COMPLEX CHAIN R
(Homo
sapiens)		4 / 5ASP R 287
SER R 285
GLY R 248
ARG R 293
None
0.88A21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_A_SC2A1290_1
(FICOLIN-2)		5a6c G-PROTEIN-SIGNALING
MODULATOR 2, AFADIN
(Homo
sapiens)		4 / 5ASP A  81
SER A  55
LEU A  92
GLY A  93
None
0.97A22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_A_SC2A1290_1
(FICOLIN-2)		5fhx ANTIBODY FRAGMENT
HEAVY-CHAIN
(Homo
sapiens)		4 / 5SER H 237
LEU H 135
GLY H 134
ARG H 243
None
1.22A22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_A_SC2A1290_1
(FICOLIN-2)		5fql IDURONATE-2-SULFATAS
E
(Homo
sapiens)		4 / 5ASP A 252
LEU A 339
GLY A 340
ARG A  48
None
0.81A16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_A_SC2A1290_1
(FICOLIN-2)		5h1k GEM-ASSOCIATED
PROTEIN 5
(Homo
sapiens)		4 / 5ASP A 557
SER A 559
LEU A 553
GLY A 554
None
1.22A15.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_A_SC2A1290_1
(FICOLIN-2)		5hvf CARBOXYPEPTIDASE B2
(Homo
sapiens)		4 / 5SER A 289
LEU A 373
GLY A 371
ARG A 214
None
0.91A19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_A_SC2A1290_1
(FICOLIN-2)		5npr UDP-N-ACETYLGLUCOSAM
INE--PEPTIDE
N-ACETYLGLUCOSAMINYL
TRANSFERASE 110 KDA
SUBUNIT
(Homo
sapiens)		4 / 5ASP A 554
SER A 552
LEU A 653
GLY A 654
None
1.20A16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1289_1
(FICOLIN-2)		2oq1 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens)		4 / 4ARG A  43
ASP A 246
THR A 229
LYS A 244
None
1.23A19.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2J2P_B_SC2B1289_1
(FICOLIN-2)		4r9j FICOLIN-2
(Homo
sapiens)		4 / 4ARG G 132
ASP G 133
THR G 136
LYS G 221
SO4  G 305 (-4.8A)
SO4  G 305 (-3.3A)
SO4  G 305 (-3.5A)
SO4  G 305 (-2.6A)
0.24A99.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2J2P_B_SC2B1290_1
(FICOLIN-2)		2d39 FICOLIN-1
(Homo
sapiens)		6 / 8SER A 129
LEU A 145
ASP A 147
ASP A 149
ARG A 160
GLU A 320
None
0.48A81.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		2fbv WERNER SYNDROME
HELICASE
(Homo
sapiens)		4 / 8SER A  66
LEU A 124
LEU A 102
ASP A  68
None
1.02A21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		2fvz INOSITOL
MONOPHOSPHATASE 2
(Homo
sapiens)		4 / 8SER A 206
LEU A 209
SER A 207
ASP A 231
None
1.06A19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		2g5t DIPEPTIDYL PEPTIDASE
4
(Homo
sapiens)		4 / 8LEU A 410
SER A 412
LEU A 436
ASP A 413
None
1.09A15.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2J2P_B_SC2B1290_1
(FICOLIN-2)		2wnp FICOLIN-1
(Homo
sapiens)		5 / 8SER F 100
ASP F 118
ASP F 120
ARG F 131
GLU F 291
None
0.53A83.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2J2P_B_SC2B1290_1
(FICOLIN-2)		2wnp FICOLIN-1
(Homo
sapiens)		5 / 8SER F 100
LEU F 116
ASP F 118
ASP F 120
ARG F 131
None
0.24A83.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		3mi9 CELL DIVISION
PROTEIN KINASE 9
(Homo
sapiens)		4 / 8LEU A 137
LEU A 212
ASP A 305
ASP A 307
None
0.91A17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		4f9o HEXOKINASE-1
(Homo
sapiens)		4 / 8SER A 449
LEU A  93
ASP A  84
ASP A 209
0NZ  A1002 (-2.8A)
None
0NZ  A1002 (-2.7A)
BGC  A1001 ( 3.0A)
1.10A13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		4gtu GLUTATHIONE
S-TRANSFERASE
(Homo
sapiens)		4 / 8SER A  25
LEU A  20
LEU A  62
ASP A  64
None
1.10A19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		4gwn MEPRIN A SUBUNIT
BETA
(Homo
sapiens)		4 / 8LEU A 568
LEU A 501
ASP A 503
ASP A 572
None
1.06A17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		4jon CENTROSOMAL PROTEIN
OF 170 KDA
(Homo
sapiens)		4 / 8SER A  11
LEU A  95
SER A  10
ARG A  88
None
0.84A21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		4nhy 2-OXOGLUTARATE AND
IRON-DEPENDENT
OXYGENASE
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens)		4 / 8LEU A  83
LEU A 104
ASP A 102
ASP A  87
None
0.91A14.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2J2P_B_SC2B1290_1
(FICOLIN-2)		4r9j FICOLIN-2
(Homo
sapiens)		6 / 8SER G  91
LEU G 107
ASP G 109
ASP G 111
ARG G 122
GLU G 282
None
0.29A99.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		4ruh CYTOSOLIC
NON-SPECIFIC
DIPEPTIDASE
(Homo
sapiens)		4 / 8LEU A 199
LEU A 305
ASP A 283
ARG A 308
None
1.08A19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		5van BETA-KLOTHO
(Homo
sapiens)		4 / 8LEU A 823
LEU A 872
ASP A 745
GLU A 768
None
0.96A17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1294_1
(FICOLIN-2)		1eak 72 KDA TYPE IV
COLLAGENASE
(Homo
sapiens)		5 / 9GLY A 418
LEU A 420
SER A 434
ASP A 436
ASP A 416
None
1.37A17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1294_1
(FICOLIN-2)		2cjw GTP-BINDING PROTEIN
GEM
(Homo
sapiens)		5 / 9VAL A  86
GLY A  82
LEU A 154
LEU A 129
ASP A 131
GDP  A 999 (-4.1A)
None
None
None
MG  A1000 ( 4.1A)
1.01A21.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2J2P_B_SC2B1294_1
(FICOLIN-2)		2d39 FICOLIN-1
(Homo
sapiens)		5 / 9SER A 129
LEU A 145
ASP A 147
ASP A 149
GLU A 320
None
0.39A81.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1294_1
(FICOLIN-2)		2fvz INOSITOL
MONOPHOSPHATASE 2
(Homo
sapiens)		5 / 9GLY A 205
SER A 206
LEU A 209
SER A 207
ASP A 231
None
1.31A19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1294_1
(FICOLIN-2)		2ht6 GTP-BINDING PROTEIN
GEM
(Homo
sapiens)		5 / 9VAL A  86
GLY A  82
LEU A 154
LEU A 129
ASP A 131
GDP  A 545 (-4.1A)
None
None
None
MG  A 344 ( 4.1A)
0.94A21.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2J2P_B_SC2B1294_1
(FICOLIN-2)		2wnp FICOLIN-1
(Homo
sapiens)		5 / 9SER F 100
LEU F 116
ASP F 118
ASP F 120
GLU F 291
None
0.48A83.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1294_1
(FICOLIN-2)		3mi9 CELL DIVISION
PROTEIN KINASE 9
(Homo
sapiens)		5 / 9LEU A 137
SER A 306
LEU A 212
ASP A 305
ASP A 307
None
1.46A17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1294_1
(FICOLIN-2)		3msx RHO
GTPASE-ACTIVATING
PROTEIN 20
(Homo
sapiens)		5 / 9GLY B 443
SER B 444
LEU B 518
SER B 448
ASP B 449
None
1.45A22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1294_1
(FICOLIN-2)		4a6e HYDROXYINDOLE
O-METHYLTRANSFERASE
(Homo
sapiens)		5 / 9VAL A 208
GLY A 188
LEU A 250
LEU A 265
ASP A 210
None
SAM  A1349 ( 4.0A)
None
None
SAM  A1349 (-2.9A)
1.47A20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1294_1
(FICOLIN-2)		4bx9 VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 33A
(Homo
sapiens)		5 / 9VAL A 477
GLY A 491
SER A 490
LEU A 244
LEU A 374
None
1.25A18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1294_1
(FICOLIN-2)		4cby HISTONE DEACETYLASE
4
(Homo
sapiens)		5 / 9GLY A 932
SER A 931
LEU A 970
ASP A 838
ASP A 840
None
None
None
NA  A2036 (-2.7A)
ZN  A2034 (-2.0A)
1.32A19.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2J2P_B_SC2B1294_1
(FICOLIN-2)		4r9j FICOLIN-2
(Homo
sapiens)		5 / 9SER G  91
LEU G 107
ASP G 109
ASP G 111
GLU G 282
None
0.32A99.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1294_1
(FICOLIN-2)		5vfr PROTEASOME SUBUNIT
ALPHA TYPE-2
(Homo
sapiens)		5 / 9VAL H  29
GLY H  78
LEU H 134
LEU H  86
ASP H  82
None
1.20Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_C_SC2C1289_1
(FICOLIN-2)		1dtd CARBOXYPEPTIDASE A2
(Homo
sapiens)		4 / 6ARG A 479
SER A 553
LEU A 636
GLY A 634
None
1.03A19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_C_SC2C1289_1
(FICOLIN-2)		1kwm PROCARBOXYPEPTIDASE
B
(Homo
sapiens)		4 / 6ARG A 124
SER A 197
LEU A 280
GLY A 278
None
0.94A19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_C_SC2C1289_1
(FICOLIN-2)		1zli CARBOXYPEPTIDASE B
(Homo
sapiens)		4 / 6ARG A 124
SER A 197
LEU A 280
GLY A 278
None
1.03A23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_C_SC2C1289_1
(FICOLIN-2)		2boa CARBOXYPEPTIDASE A4
(Homo
sapiens)		4 / 6ARG A1124
SER A1197
LEU A1280
GLY A1278
None
1.03A19.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2J2P_C_SC2C1289_1
(FICOLIN-2)		2d39 FICOLIN-1
(Homo
sapiens)		5 / 6ASP A 163
SER A 165
SER A 181
LEU A 183
GLY A 184
None
0.25A81.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_C_SC2C1289_1
(FICOLIN-2)		2pcu CARBOXYPEPTIDASE A4
(Homo
sapiens)		4 / 6ARG A 124
SER A 197
LEU A 280
GLY A 278
GOL  A 501 (-4.0A)
None
GOL  A 501 (-4.4A)
None
1.03A21.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2J2P_C_SC2C1289_1
(FICOLIN-2)		2wnp FICOLIN-1
(Homo
sapiens)		5 / 6ASP F 134
SER F 136
SER F 152
LEU F 154
GLY F 155
None
0.23A83.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_C_SC2C1289_1
(FICOLIN-2)		3wsy SORTILIN-RELATED
RECEPTOR
(Homo
sapiens)		4 / 6ARG A 298
SER A 364
SER A 393
GLY A 396
None
None
None
NAG  A 802 (-4.1A)
0.81A14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_C_SC2C1289_1
(FICOLIN-2)		4kwg ALDEHYDE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens)		4 / 6SER A 423
SER A 273
LEU A 427
GLY A 271
None
1.03A20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_C_SC2C1289_1
(FICOLIN-2)		4kwg ALDEHYDE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens)		4 / 6SER A 423
SER A 471
LEU A 427
GLY A 426
None
0.99A20.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2J2P_C_SC2C1289_1
(FICOLIN-2)		4r9j FICOLIN-2
(Homo
sapiens)		5 / 6ASP G 125
SER G 127
SER G 143
LEU G 145
GLY G 146
None
0.41A99.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_C_SC2C1289_1
(FICOLIN-2)		4uf4 CARBOXYPEPTIDASE A1
(Homo
sapiens)		4 / 6ARG A 234
SER A 307
LEU A 390
GLY A 388
None
1.01A19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_C_SC2C1289_1
(FICOLIN-2)		4yk6 ADENOMATOUS
POLYPOSIS COLI
PROTEIN
(Homo
sapiens)		4 / 6ASP A 482
SER A 494
LEU A 488
GLY A 487
None
0.97A19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_C_SC2C1289_1
(FICOLIN-2)		5a31 THE
ANAPHASE-PROMOTING
COMPLEX CHAIN R
(Homo
sapiens)		4 / 6ARG R 293
ASP R 287
SER R 285
GLY R 248
None
1.00A21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_C_SC2C1289_1
(FICOLIN-2)		5a6c G-PROTEIN-SIGNALING
MODULATOR 2, AFADIN
(Homo
sapiens)		4 / 6ASP A  81
SER A  55
LEU A  92
GLY A  93
None
1.00A22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_C_SC2C1289_1
(FICOLIN-2)		5hvf CARBOXYPEPTIDASE B2
(Homo
sapiens)		4 / 6ARG A 214
SER A 289
LEU A 373
GLY A 371
None
1.01A19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_C_SC2C1289_1
(FICOLIN-2)		6b5i RETINAL
DEHYDROGENASE 2
(Homo
sapiens)		4 / 6SER A 441
SER A 291
LEU A 445
GLY A 289
None
0.98A15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_C_SC2C1289_1
(FICOLIN-2)		6b5i RETINAL
DEHYDROGENASE 2
(Homo
sapiens)		4 / 6SER A 441
SER A 489
LEU A 445
GLY A 444
None
0.96A15.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2J2P_C_SC2C1290_1
(FICOLIN-2)		4r9j FICOLIN-2
(Homo
sapiens)		4 / 4ARG G 132
ASP G 133
THR G 136
LYS G 221
SO4  G 305 (-4.8A)
SO4  G 305 (-3.3A)
SO4  G 305 (-3.5A)
SO4  G 305 (-2.6A)
0.32A99.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_D_SC2D1290_1
(FICOLIN-2)		1oll NK RECEPTOR
(Homo
sapiens)		4 / 5GLY A  79
TRP A  82
ARG A  77
LEU A  81
None
0.79A21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_D_SC2D1290_1
(FICOLIN-2)		1vzo RIBOSOMAL PROTEIN S6
KINASE ALPHA 5
(Homo
sapiens)		4 / 5TRP A 238
TRP A 239
ARG A 301
LEU A 293
None
1.47A19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_D_SC2D1290_1
(FICOLIN-2)		2edo CD48 ANTIGEN
(Homo
sapiens)		4 / 5GLY A  73
TRP A  39
TRP A  50
LEU A  68
None
1.22A18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_D_SC2D1290_1
(FICOLIN-2)		3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens)		4 / 5TRP A 368
TRP A 369
ARG A 431
LEU A 423
None
1.46A16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_D_SC2D1290_1
(FICOLIN-2)		3o96 RAC-ALPHA
SERINE/THREONINE-PRO
TEIN KINASE
(Homo
sapiens)		4 / 5TRP A 332
TRP A 333
ARG A 391
LEU A 383
TRP  A 332 ( 0.5A)
TRP  A 333 ( 0.5A)
ARG  A 391 ( 0.6A)
LEU  A 383 ( 0.6A)
1.48A19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_D_SC2D1290_1
(FICOLIN-2)		4fr4 SERINE/THREONINE-PRO
TEIN KINASE 32A
(Homo
sapiens)		4 / 5TRP A 206
TRP A 207
ARG A 268
LEU A 260
None
1.37A18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_D_SC2D1290_1
(FICOLIN-2)		4yhj G PROTEIN-COUPLED
RECEPTOR KINASE 4
(Homo
sapiens)		4 / 5TRP A 369
TRP A 370
ARG A 432
LEU A 424
None
1.47A16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_D_SC2D1290_1
(FICOLIN-2)		5loh SERINE/THREONINE-PRO
TEIN KINASE
GREATWALL,SERINE/THR
EONINE-PROTEIN
KINASE GREATWALL
(Homo
sapiens)		4 / 5TRP A 761
TRP A 762
ARG A 823
LEU A 815
 CL  A 902 (-4.2A)
None
None
None
1.40A17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1289_1
(FICOLIN-2)		1do5 HUMAN COPPER
CHAPERONE FOR
SUPEROXIDE DISMUTASE
DOMAIN II
(Homo
sapiens)		4 / 6ASP A 167
ARG A 163
ASP A 151
ASP A 185
 ZN  A  28 (-2.2A)
None
None
None
0.81A22.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2J2P_E_SC2E1289_1
(FICOLIN-2)		2d39 FICOLIN-1
(Homo
sapiens)		4 / 6ASP A 167
ARG A 170
ASP A 171
LYS A 259
None
0.57A81.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1289_1
(FICOLIN-2)		2i1y RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE
(Homo
sapiens)		4 / 6ARG A 750
ASP A 747
THR A 728
ASP A 763
None
1.00A20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1289_1
(FICOLIN-2)		2o8e DNA MISMATCH REPAIR
PROTEIN MSH6
(Homo
sapiens)		4 / 6ASP B 736
ARG B1172
ASP B1171
THR B 716
None
1.12A12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1289_1
(FICOLIN-2)		2ooq RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE T
(Homo
sapiens)		4 / 6ARG A 950
ASP A 947
THR A 928
ASP A 963
None
1.14A21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1289_1
(FICOLIN-2)		2oq1 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens)		4 / 6ARG A  43
ASP A 246
THR A 229
LYS A 244
None
1.19A19.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2J2P_E_SC2E1289_1
(FICOLIN-2)		2wnp FICOLIN-1
(Homo
sapiens)		4 / 6ASP F 138
ARG F 141
ASP F 142
LYS F 230
None
0.56A83.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1289_1
(FICOLIN-2)		3fg7 VILLIN-1
(Homo
sapiens)		4 / 6ARG A 689
ASP A 690
THR A 693
ASP A 653
None
0.84A19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1289_1
(FICOLIN-2)		3l2j FUSION PROTEIN OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND PARATHYROID
HORMONE/PARATHYROID
HORMONE-RELATED
PEPTIDE RECEPTOR
(Escherichia
coli;
Homo
sapiens)		4 / 6ASP A-147
THR A-151
LYS A-144
ASP A  14
None
1.20A16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1289_1
(FICOLIN-2)		3py7 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,PAXILLIN
LD1,PROTEIN E6
CHIMERA
(Deltapapillomavi
rus
4;
Escherichia
coli;
Homo
sapiens)		4 / 6ASP A 198
THR A 194
LYS A 201
ASP A 359
None
1.21A16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1289_1
(FICOLIN-2)		4ifp MALTOSE-BINDING
PERIPLASMIC
PROTEIN,NACHT, LRR
AND PYD
DOMAINS-CONTAINING
PROTEIN 1
(Escherichia
coli;
Homo
sapiens)		4 / 6ASP A 198
THR A 194
LYS A 201
ASP A 359
None
1.21A20.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2J2P_E_SC2E1289_1
(FICOLIN-2)		4r9j FICOLIN-2
(Homo
sapiens)		5 / 6ASP G 129
ARG G 132
ASP G 133
THR G 136
LYS G 221
None
SO4  G 305 (-4.8A)
SO4  G 305 (-3.3A)
SO4  G 305 (-3.5A)
SO4  G 305 (-2.6A)
0.25A99.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1289_1
(FICOLIN-2)		4rwf MALTOSE TRANSPORTER
SUBUNIT, RECEPTOR
ACTIVITY-MODIFYING
PROTEIN 2,
CALCITONIN
GENE-RELATED PEPTIDE
TYPE 1 RECEPTOR
FUSION PROTEIN
(Escherichia
coli;
Homo
sapiens)		4 / 6ASP A 199
THR A 195
LYS A 202
ASP A 360
None
1.19A16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1289_1
(FICOLIN-2)		4wrn MALTOSE-BINDING
PERIPLASMIC
PROTEIN,UROMODULIN
(Escherichia
coli;
Homo
sapiens)		4 / 6ASP A 221
THR A 217
LYS A 224
ASP A 382
None
1.27A15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1289_1
(FICOLIN-2)		4xaj MALTOSE-BINDING
PERIPLASMIC
PROTEIN,NUCLEAR
RECEPTOR SUBFAMILY 2
GROUP E MEMBER 1
(Escherichia
coli;
Homo
sapiens)		4 / 6ASP A 199
THR A 195
LYS A 202
ASP A 360
None
1.24A16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1289_1
(FICOLIN-2)		5hzv MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ENDOGLIN
(Escherichia
coli;
Homo
sapiens)		4 / 6ASP A 564
THR A 560
LYS A 567
ASP A 725
None
1.23A15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1289_1
(FICOLIN-2)		5hzw MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ENDOGLIN
(Escherichia
coli;
Homo
sapiens)		4 / 6ASP A 252
THR A 248
LYS A 255
ASP A 413
None
1.26A15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1289_1
(FICOLIN-2)		5jj4 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,SINGLE-STRAN
DED DNA CYTOSINE
DEAMINASE
(Escherichia
coli;
Homo
sapiens)		4 / 6ASP C 197
THR C 193
LYS C 200
ASP C 358
None
1.20A17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1289_1
(FICOLIN-2)		5lug SPINDLIN-LIKE
PROTEIN 2, ISOFORM
CRA_A
(Homo
sapiens)		4 / 6ASP A 112
ARG A  53
THR A  71
ASP A  88
None
1.17A18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1289_1
(FICOLIN-2)		5v6y MALTOSE-BINDING
PERIPLASMIC
PROTEIN,RECEPTOR
ACTIVITY-MODIFYING
PROTEIN 1,CALCITONIN
GENE-RELATED PEPTIDE
TYPE 1 RECEPTOR
(Escherichia
coli;
Homo
sapiens)		4 / 6ASP A 199
THR A 195
LYS A 202
ASP A 360
None
1.16A17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1289_1
(FICOLIN-2)		6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)
(Homo
sapiens)		4 / 6ARG A1662
ASP A2043
THR A2044
ASP A1705
None
1.24A0.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1289_1
(FICOLIN-2)		6d7t TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 6
(Homo
sapiens)		4 / 6ASP A 227
ARG A 190
ASP A 188
ASP A 223
None
1.23Aundetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2J2P_E_SC2E1290_1
(FICOLIN-2)		2d39 FICOLIN-1
(Homo
sapiens)		5 / 9SER A 129
LEU A 145
ASP A 147
ARG A 160
GLU A 320
None
0.43A81.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2J2P_E_SC2E1290_1
(FICOLIN-2)		2wnp FICOLIN-1
(Homo
sapiens)		5 / 9SER F 100
LEU F 116
ASP F 118
ARG F 131
GLU F 291
None
0.49A83.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2J2P_E_SC2E1290_1
(FICOLIN-2)		4r9j FICOLIN-2
(Homo
sapiens)		5 / 9SER G  91
LEU G 107
ASP G 109
ARG G 122
GLU G 282
None
0.23A99.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1290_1
(FICOLIN-2)		5i85 SPHINGOMYELIN
PHOSPHODIESTERASE
(Homo
sapiens)		5 / 9SER A 436
SER A 603
LEU A 606
LEU A 472
GLU A 469
None
1.27A16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1291_1
(FICOLIN-2)		2oq1 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens)		4 / 4ASP A   5
LEU A  45
GLY A  46
ARG A 121
None
1.19A19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1291_1
(FICOLIN-2)		2xoc E3 UBIQUITIN-PROTEIN
LIGASE CHFR
(Homo
sapiens)		4 / 4ASP A 591
LEU A 606
GLY A 605
ARG A 610
None
1.47A20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1291_1
(FICOLIN-2)		4rwt LEIOMODIN-2
(Homo
sapiens)		4 / 4ASP C 222
LEU C 254
GLY C 250
ARG C 258
None
1.31A17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1291_1
(FICOLIN-2)		4z79 LEIOMODIN-1
ACTIN-BINDING SITE 2
(ABS2)
(Homo
sapiens)		4 / 4ASP A 373
LEU A 405
GLY A 401
ARG A 409
None
None
None
CL  A 507 (-4.1A)
1.25A19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1291_1
(FICOLIN-2)		4z8g TROPOMODULIN-1,
LEIOMODIN-1 CHIMERA
(TP1 ABS2)
(Homo
sapiens)		4 / 4ASP A 373
LEU A 405
GLY A 401
ARG A 409
None
1.30A17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1291_1
(FICOLIN-2)		4z94 GELSOLIN,
TROPOMODULIN-1,
LEIOMODIN-1 CHIMERA
(Homo
sapiens)		4 / 4ASP G1373
LEU G1405
GLY G1401
ARG G1409
None
1.14A21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1291_1
(FICOLIN-2)		5all SOLUBLE EPOXIDE
HYDROLASE
(Homo
sapiens)		4 / 4ASP A 128
LEU A 139
GLY A 135
ARG A  99
None
1.38A15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1291_1
(FICOLIN-2)		5e3c DIPEPTIDYL PEPTIDASE
3
(Homo
sapiens)		4 / 4ASP A 633
LEU A 640
GLY A 637
ARG A 624
None
1.26A13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1291_1
(FICOLIN-2)		5fbh EXTRACELLULAR
CALCIUM-SENSING
RECEPTOR
(Homo
sapiens)		4 / 4ASP B 275
LEU B 304
GLY B 273
ARG B  62
None
1.31A17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1291_1
(FICOLIN-2)		5fql IDURONATE-2-SULFATAS
E
(Homo
sapiens)		4 / 4ASP A 252
LEU A 339
GLY A 340
ARG A  48
None
0.84A16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1289_1
(FICOLIN-2)		1aye PROCARBOXYPEPTIDASE
A2
(Homo
sapiens)		4 / 6ARG A 124
SER A 197
LEU A 280
GLY A 278
None
1.02A19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1289_1
(FICOLIN-2)		1dtd CARBOXYPEPTIDASE A2
(Homo
sapiens)		4 / 6ARG A 479
SER A 553
LEU A 636
GLY A 634
None
1.01A19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1289_1
(FICOLIN-2)		1kwm PROCARBOXYPEPTIDASE
B
(Homo
sapiens)		4 / 6ARG A 124
SER A 197
LEU A 280
GLY A 278
None
0.92A19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1289_1
(FICOLIN-2)		1zli CARBOXYPEPTIDASE B
(Homo
sapiens)		4 / 6ARG A 124
SER A 197
LEU A 280
GLY A 278
None
1.01A23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1289_1
(FICOLIN-2)		2boa CARBOXYPEPTIDASE A4
(Homo
sapiens)		4 / 6ARG A1124
SER A1197
LEU A1280
GLY A1278
None
1.01A19.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2J2P_F_SC2F1289_1
(FICOLIN-2)		2d39 FICOLIN-1
(Homo
sapiens)		5 / 6ASP A 163
SER A 165
SER A 181
LEU A 183
GLY A 184
None
0.27A81.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1289_1
(FICOLIN-2)		2jif SHORT/BRANCHED CHAIN
SPECIFIC ACYL-COA
DEHYDROGENASE
(Homo
sapiens)		4 / 6ARG A 405
ASP A 132
SER A 134
SER A  87
None
1.04A20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1289_1
(FICOLIN-2)		2pcu CARBOXYPEPTIDASE A4
(Homo
sapiens)		4 / 6ARG A 124
SER A 197
LEU A 280
GLY A 278
GOL  A 501 (-4.0A)
None
GOL  A 501 (-4.4A)
None
1.00A21.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2J2P_F_SC2F1289_1
(FICOLIN-2)		2wnp FICOLIN-1
(Homo
sapiens)		5 / 6ASP F 134
SER F 136
SER F 152
LEU F 154
GLY F 155
None
0.28A83.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1289_1
(FICOLIN-2)		3fju CARBOXYPEPTIDASE A1
(Homo
sapiens)		4 / 6ARG A 124
SER A 197
LEU A 280
GLY A 278
None
1.03A18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1289_1
(FICOLIN-2)		3wsy SORTILIN-RELATED
RECEPTOR
(Homo
sapiens)		4 / 6ARG A 298
SER A 364
SER A 393
GLY A 396
None
None
None
NAG  A 802 (-4.1A)
0.80A14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1289_1
(FICOLIN-2)		4kwg ALDEHYDE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens)		4 / 6SER A 423
SER A 471
LEU A 427
GLY A 426
None
0.98A20.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2J2P_F_SC2F1289_1
(FICOLIN-2)		4r9j FICOLIN-2
(Homo
sapiens)		5 / 6ASP G 125
SER G 127
SER G 143
LEU G 145
GLY G 146
None
0.37A99.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1289_1
(FICOLIN-2)		4uf4 CARBOXYPEPTIDASE A1
(Homo
sapiens)		4 / 6ARG A 234
SER A 307
LEU A 390
GLY A 388
None
0.98A19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1289_1
(FICOLIN-2)		4yk6 ADENOMATOUS
POLYPOSIS COLI
PROTEIN
(Homo
sapiens)		4 / 6ASP A 482
SER A 494
LEU A 488
GLY A 487
None
0.99A19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1289_1
(FICOLIN-2)		5a6c G-PROTEIN-SIGNALING
MODULATOR 2, AFADIN
(Homo
sapiens)		4 / 6ASP A  81
SER A  55
LEU A  92
GLY A  93
None
0.98A22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1289_1
(FICOLIN-2)		5hvf CARBOXYPEPTIDASE B2
(Homo
sapiens)		4 / 6ARG A 214
SER A 289
LEU A 373
GLY A 371
None
0.99A19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1289_1
(FICOLIN-2)		6b5i RETINAL
DEHYDROGENASE 2
(Homo
sapiens)		4 / 6SER A 441
SER A 291
LEU A 445
GLY A 289
None
1.00A15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1289_1
(FICOLIN-2)		6b5i RETINAL
DEHYDROGENASE 2
(Homo
sapiens)		4 / 6SER A 441
SER A 489
LEU A 445
GLY A 444
None
0.95A15.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2J2P_F_SC2F1290_1
(FICOLIN-2)		4r9j FICOLIN-2
(Homo
sapiens)		4 / 4ARG G 132
ASP G 133
THR G 136
LYS G 221
SO4  G 305 (-4.8A)
SO4  G 305 (-3.3A)
SO4  G 305 (-3.5A)
SO4  G 305 (-2.6A)
0.30A99.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1291_1
(FICOLIN-2)		1hzf COMPLEMENT FACTOR
C4A
(Homo
sapiens)		4 / 6LEU A1003
SER A1006
ASP A1010
GLU A1072
None
1.15A24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1291_1
(FICOLIN-2)		2bkr SENTRIN-SPECIFIC
PROTEASE 8
(Homo
sapiens)		4 / 6LEU A 106
SER A 104
ASP A 119
GLU A 151
None
1.16A24.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2J2P_F_SC2F1291_1
(FICOLIN-2)		2d39 FICOLIN-1
(Homo
sapiens)		4 / 6SER A 129
ASP A 147
ASP A 149
GLU A 320
None
0.48A81.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1291_1
(FICOLIN-2)		2fvz INOSITOL
MONOPHOSPHATASE 2
(Homo
sapiens)		4 / 6SER A 206
LEU A 209
SER A 207
ASP A 231
None
1.03A19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1291_1
(FICOLIN-2)		2hgm HETEROGENEOUS
NUCLEAR
RIBONUCLEOPROTEIN F
(Homo
sapiens)		4 / 6SER A 104
SER A 187
ASP A 110
ASP A 106
None
1.15A20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1291_1
(FICOLIN-2)		2nz2 ARGININOSUCCINATE
SYNTHASE
(Homo
sapiens)		4 / 6SER A  92
LEU A  89
ASP A 124
GLU A 270
None
None
ASP  A 501 ( 3.6A)
CIR  A 502 (-2.6A)
1.07A19.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2J2P_F_SC2F1291_1
(FICOLIN-2)		2wnp FICOLIN-1
(Homo
sapiens)		4 / 6SER F 100
ASP F 118
ASP F 120
GLU F 291
None
0.45A83.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1291_1
(FICOLIN-2)		3egi TRIMETHYLGUANOSINE
SYNTHASE HOMOLOG
(Homo
sapiens)		4 / 6SER A 816
LEU A 817
ASP A 810
ASP A 812
None
1.18A23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1291_1
(FICOLIN-2)		4cgb ECHINODERM
MICROTUBULE-ASSOCIAT
ED PROTEIN-LIKE 2
(Homo
sapiens)		4 / 6LEU A  22
SER A  20
ASP A  17
ASP A  16
None
1.16A14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1291_1
(FICOLIN-2)		4llv 4E10 FV HEAVY CHAIN
(Homo
sapiens)		4 / 6SER A  16
LEU A  82
SER A  17
GLU A  10
None
1.17A21.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2J2P_F_SC2F1291_1
(FICOLIN-2)		4r9j FICOLIN-2
(Homo
sapiens)		4 / 6SER G  91
ASP G 109
ASP G 111
GLU G 282
None
0.39A99.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1291_1
(FICOLIN-2)		5jcg THIOREDOXIN-DEPENDEN
T PEROXIDE
REDUCTASE,
MITOCHONDRIAL
(Homo
sapiens)		4 / 6SER A 101
LEU A 103
SER A  72
ASP A  42
None
1.21A22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1291_1
(FICOLIN-2)		5oe7 UBIQUITIN
THIOESTERASE OTULIN
(Homo
sapiens)		4 / 6SER A 266
LEU A 272
ASP A 264
GLU A 287
None
1.17A21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1291_1
(FICOLIN-2)		5xgc RAP1 GTPASE-GDP
DISSOCIATION
STIMULATOR 1
(Homo
sapiens)		4 / 6SER A 256
LEU A 250
ASP A 206
ASP A 254
None
1.14A18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_E_SC2E1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		1oqa BREAST CANCER TYPE 1
SUSCEPTIBILITY
PROTEIN
(Homo
sapiens)		3 / 3VAL A  79
GLN A  73
CYH A  75
None
0.76A21.11
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_E_SC2E1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		1xm9 PLAKOPHILIN 1
(Homo
sapiens)		3 / 3VAL A 283
GLN A 270
CYH A 273
None
0.43A19.29
4.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_E_SC2E1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		2aex COPROPORPHYRINOGEN
III OXIDASE,
MITOCHONDRIAL
(Homo
sapiens)		3 / 3VAL A 205
GLN A 162
CYH A 164
None
0.71A20.29
3.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_E_SC2E1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		2c7s RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE KAPPA
(Homo
sapiens)		3 / 3VAL A1068
GLN A1043
CYH A 981
None
0.58A18.69
3.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_E_SC2E1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		2iuw ALKYLATED REPAIR
PROTEIN ALKB HOMOLOG
3
(Homo
sapiens)		3 / 3VAL A 270
GLN A 108
CYH A 110
None
None
BME  A 802 (-1.9A)
0.68A21.40
4.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_E_SC2E1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens)		3 / 3VAL A 397
GLN A 452
CYH A 454
None
0.84A20.44
5.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_E_SC2E1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		2w9z G1/S-SPECIFIC
CYCLIN-D1
(Homo
sapiens)		3 / 3VAL A  77
GLN A  71
CYH A  68
None
0.84A23.95
4.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_E_SC2E1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		2yf0 MYOTUBULARIN-RELATED
PROTEIN 6
(Homo
sapiens)		3 / 3VAL A 334
GLN A 345
CYH A 347
None
0.77A18.90
3.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_E_SC2E1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		3llm ATP-DEPENDENT RNA
HELICASE A
(Homo
sapiens)		3 / 3VAL A 563
GLN A 420
CYH A 415
None
None
ADP  A 565 (-4.8A)
0.60A22.04
6.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_E_SC2E1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		3thz DNA MISMATCH REPAIR
PROTEIN MSH2
(Homo
sapiens)		3 / 3VAL A 582
GLN A 402
CYH A 404
None
0.75A13.48
1.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_E_SC2E1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		3tt9 PLAKOPHILIN-2
(Homo
sapiens)		3 / 3VAL A 391
GLN A 378
CYH A 381
None
0.71A19.76
5.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_E_SC2E1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		4c2k 3-KETOACYL-COA
THIOLASE,
MITOCHONDRIAL
(Homo
sapiens)		3 / 3VAL A   7
GLN A 104
CYH A 107
None
0.72A18.57
3.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_E_SC2E1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		4c3z MULTIDRUG
RESISTANCE-ASSOCIATE
D PROTEIN 1
(Homo
sapiens)		3 / 3VAL A 782
GLN A 742
CYH A 744
None
0.83A20.59
4.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_E_SC2E1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		4mdr AP-4 COMPLEX SUBUNIT
MU-1
(Homo
sapiens)		3 / 3VAL A 368
GLN A 373
CYH A 319
None
0.83A22.79
4.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_E_SC2E1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		4nlh TAX1-BINDING PROTEIN
1
(Homo
sapiens)		3 / 3VAL A  50
GLN A  20
CYH A  34
None
0.85A20.83
7.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_E_SC2E1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		4y7i MYOTUBULARIN-RELATED
PROTEIN 8
(Homo
sapiens)		3 / 3VAL A 336
GLN A 347
CYH A 349
None
0.70A19.63
5.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_E_SC2E1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		4ztu DNA POLYMERASE
SUBUNIT GAMMA-2,
MITOCHONDRIAL
(Homo
sapiens)		3 / 3VAL B 443
GLN B 397
CYH B 399
None
0.78A17.93
3.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_E_SC2E1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens)		3 / 3VAL A1047
GLN A1072
CYH A1074
None
0.80A9.48
1.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_E_SC2E1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		5c53 POL GAMMA B
(Homo
sapiens)		3 / 3VAL B 443
GLN B 397
CYH B 399
None
0.80A13.00
1.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_E_SC2E1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		5lst ATP-DEPENDENT DNA
HELICASE Q4
(Homo
sapiens)		3 / 3VAL A 846
GLN A1050
CYH A1052
None
0.71A14.33
3.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_E_SC2E1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		5tuv TRANSCRIPTION FACTOR
DP1
TRANSCRIPTION FACTOR
E2F5
(Homo
sapiens)		3 / 3VAL B 126
GLN A 200
CYH A 202
None
0.75A20.19
7.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_E_SC2E1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		5xzx IMPORTIN SUBUNIT
ALPHA-3
(Homo
sapiens)		3 / 3VAL A  92
GLN A 132
CYH A 122
None
0.79A18.95
2.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_E_SC2E1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		6fcx METHYLENETETRAHYDROF
OLATE REDUCTASE
(Homo
sapiens)		3 / 3VAL A 536
GLN A 634
CYH A 631
None
0.81A16.90
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_F_SC2F1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		1r4x COATOMER GAMMA
SUBUNIT
(Homo
sapiens)		3 / 3VAL A 679
GLN A 662
CYH A 665
None
0.77A22.30
4.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_F_SC2F1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		1xm9 PLAKOPHILIN 1
(Homo
sapiens)		3 / 3VAL A 283
GLN A 270
CYH A 273
None
0.58A19.29
4.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_F_SC2F1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		2c7s RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE KAPPA
(Homo
sapiens)		3 / 3VAL A1068
GLN A1043
CYH A 981
None
0.76A18.69
3.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_F_SC2F1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		2jw6 DEFORMED EPIDERMAL
AUTOREGULATORY
FACTOR 1 HOMOLOG
(Homo
sapiens)		3 / 3VAL A 521
GLN A 537
CYH A 540
None
None
ZN  A 602 (-2.3A)
0.73A11.36
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_F_SC2F1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		2nzj GTP-BINDING PROTEIN
REM 1
(Homo
sapiens)		3 / 3VAL A 133
GLN A 147
CYH A 150
None
0.76A21.03
6.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_F_SC2F1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		2rgn RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 25
(Homo
sapiens)		3 / 3VAL B 292
GLN B 254
CYH B 333
None
0.79A21.69
3.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_F_SC2F1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		2xwu IMPORTIN13
(Homo
sapiens)		3 / 3VAL B 790
GLN B 780
CYH B 821
None
0.82A12.99
1.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_F_SC2F1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		3eq5 SKI-LIKE PROTEIN
(Homo
sapiens)		3 / 3VAL A 170
GLN A 227
CYH A 230
None
0.78A21.23
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_F_SC2F1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		3llm ATP-DEPENDENT RNA
HELICASE A
(Homo
sapiens)		3 / 3VAL A 563
GLN A 420
CYH A 415
None
None
ADP  A 565 (-4.8A)
0.89A22.04
6.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_F_SC2F1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		3tt9 PLAKOPHILIN-2
(Homo
sapiens)		3 / 3VAL A 391
GLN A 378
CYH A 381
None
0.80A19.76
5.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_F_SC2F1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		4avx HEPATOCYTE GROWTH
FACTOR-REGULATED
TYROSINE KINASE
SUBSTRATE
(Homo
sapiens)		3 / 3VAL A  67
GLN A  30
CYH A  32
None
0.64A22.73
5.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_F_SC2F1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		4c2k 3-KETOACYL-COA
THIOLASE,
MITOCHONDRIAL
(Homo
sapiens)		3 / 3VAL A   7
GLN A 104
CYH A 107
None
0.80A18.57
3.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_F_SC2F1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		4c3z MULTIDRUG
RESISTANCE-ASSOCIATE
D PROTEIN 1
(Homo
sapiens)		3 / 3VAL A 782
GLN A 742
CYH A 744
None
0.90A20.59
4.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_F_SC2F1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		4g1t INTERFERON-INDUCED
PROTEIN WITH
TETRATRICOPEPTIDE
REPEATS 2
(Homo
sapiens)		3 / 3VAL A 336
GLN A 286
CYH A 289
None
0.73A17.72
3.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_F_SC2F1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		4nlh TAX1-BINDING PROTEIN
1
(Homo
sapiens)		3 / 3VAL A  50
GLN A  20
CYH A  34
None
0.85A20.83
7.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_F_SC2F1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		4owr MRNA EXPORT FACTOR
(Homo
sapiens)		3 / 3VAL A 101
GLN A  82
CYH A  68
None
0.82A23.58
4.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_F_SC2F1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens)		3 / 3VAL A1047
GLN A1072
CYH A1074
None
0.89A9.48
1.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_F_SC2F1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens)		3 / 3VAL A 109
GLN A 137
CYH A 133
None
IDV  A 401 (-3.7A)
IDV  A 401 (-4.6A)
0.81A19.80
3.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_F_SC2F1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		5ku1 MITOCHONDRIAL RHO
GTPASE 1
(Homo
sapiens)		3 / 3VAL A 434
GLN A 555
CYH A 493
None
0.92A17.17
3.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_F_SC2F1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		5m9n TUDOR
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens)		3 / 3VAL A 649
GLN A 512
CYH A 510
None
0.83A23.05
5.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_F_SC2F1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		5xzx IMPORTIN SUBUNIT
ALPHA-3
(Homo
sapiens)		3 / 3VAL A  92
GLN A 132
CYH A 122
None
0.82A18.95
2.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_F_SC2F1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		5yt6 TAX1-BINDING PROTEIN
1
(Homo
sapiens)		3 / 3VAL F  57
GLN F  43
CYH F  40
None
None
ZN  F 101 (-2.3A)
0.84A8.70
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NN4_A_SC2A1016_1
(LYSOSOMAL
ALPHA-GLUCOSIDASE)		4z2a FURIN
(Homo
sapiens)		4 / 4HIS A 486
GLY A 572
ARG A 391
THR A 573
None
1.23A18.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NN4_A_SC2A1016_1
(LYSOSOMAL
ALPHA-GLUCOSIDASE)		5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens)		4 / 4HIS A 432
GLY A 435
ARG A 437
THR A 834
GOL  A1038 (-3.6A)
GOL  A1038 ( 4.0A)
GOL  A1038 (-3.5A)
GOL  A1038 (-3.3A)
0.13A100.00