POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
13GS_A_SASA211_1
(GLUTATHIONE
S-TRANSFERASE)		1lbk GLUTATHIONE
S-TRANSFERASE CLASS
PI CHIMAERA (CODA)
(Homo
sapiens)		9 / 10TYR A   7
PHE A   8
PRO A   9
VAL A  10
ARG A  13
VAL A  35
ILE A 104
TYR A 108
PRO A 202
None
GSH  A 504 (-4.7A)
None
None
GSH  A 504 (-3.7A)
None
None
None
None
0.59A97.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_A_SASA211_1
(GLUTATHIONE
S-TRANSFERASE)		2esv KK50.4 T CELL
RECEPTOR BETA CHAIN
(Homo
sapiens)		5 / 10VAL E 123
VAL E 158
ILE E  13
PRO E 233
GLY E 219
None
1.43A20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_A_SASA211_1
(GLUTATHIONE
S-TRANSFERASE)		2eyr NKT12
(Homo
sapiens)		5 / 10VAL B 123
VAL B 158
ILE B  13
PRO B 233
GLY B 219
None
1.46A20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_A_SASA211_1
(GLUTATHIONE
S-TRANSFERASE)		3p9h TUMOR SUSCEPTIBILITY
GENE 101 PROTEIN
(Homo
sapiens)		5 / 10PHE A 135
VAL A  61
VAL A 130
PRO A  62
GLY A 136
None
1.31A19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_A_SASA211_1
(GLUTATHIONE
S-TRANSFERASE)		5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens)		5 / 10PHE A 192
VAL A 190
ILE A 173
PRO A 195
GLY A  69
None
1.23A9.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_A_SASA211_1
(GLUTATHIONE
S-TRANSFERASE)		5k1c WD REPEAT-CONTAINING
PROTEIN 20
(Homo
sapiens)		5 / 10TYR C  74
PHE C  67
VAL C  69
VAL C  50
GLY C 553
None
1.37A16.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
13GS_B_SASB211_1
(GLUTATHIONE
S-TRANSFERASE)		1lbk GLUTATHIONE
S-TRANSFERASE CLASS
PI CHIMAERA (CODA)
(Homo
sapiens)		8 / 9PHE A   8
PRO A   9
VAL A  10
ARG A  13
VAL A  35
ILE A 104
TYR A 108
PRO A 202
GSH  A 504 (-4.7A)
None
None
GSH  A 504 (-3.7A)
None
None
None
None
0.62A97.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_B_SASB211_1
(GLUTATHIONE
S-TRANSFERASE)		2esv KK50.4 T CELL
RECEPTOR BETA CHAIN
(Homo
sapiens)		5 / 9VAL E 123
VAL E 158
ILE E  13
PRO E 233
GLY E 219
None
1.43A20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_B_SASB211_1
(GLUTATHIONE
S-TRANSFERASE)		2eyr NKT12
(Homo
sapiens)		5 / 9VAL B 123
VAL B 158
ILE B  13
PRO B 233
GLY B 219
None
1.46A20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_B_SASB211_1
(GLUTATHIONE
S-TRANSFERASE)		3p9h TUMOR SUSCEPTIBILITY
GENE 101 PROTEIN
(Homo
sapiens)		5 / 9PHE A 135
VAL A  61
VAL A 130
PRO A  62
GLY A 136
None
1.31A19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_B_SASB211_1
(GLUTATHIONE
S-TRANSFERASE)		5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens)		5 / 9PHE A 192
VAL A 190
ILE A 173
PRO A 195
GLY A  69
None
1.23A9.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		2ad1 SULFOTRANSFERASE 1C2
(Homo
sapiens)		5 / 12LEU A 164
PHE A 160
TRP A 156
TYR A 159
PRO A 133
None
1.08A21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		2i7d 5'(3')-DEOXYRIBONUCL
EOTIDASE, CYTOSOLIC
TYPE
(Homo
sapiens)		5 / 12LEU A 102
CYH A 108
PHE A  71
ASP A  17
GLY A  13
DUR  A 300 (-4.7A)
None
None
None
MG  A 728 ( 4.5A)
1.16A22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		2qob EPHRIN RECEPTOR
(Homo
sapiens)		5 / 12SER A 809
LEU A 747
PHE A 871
ASP A 739
GLY A 741
None
1.44A21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens)		5 / 12SER A 863
LEU A 801
PHE A 925
ASP A 793
GLY A 795
None
1.47A20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		2rhz LETHAL(3)MALIGNANT
BRAIN TUMOR-LIKE
PROTEIN
(Homo
sapiens)		5 / 12SER A 394
CYH A 390
PHE A 375
TYR A 388
ALA A 365
None
1.17A20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens)		5 / 12SER A 821
LEU A 759
PHE A 883
ASP A 751
GLY A 753
None
1.43A22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		3fhc ATP-DEPENDENT RNA
HELICASE DDX19B
(Homo
sapiens)		5 / 12LEU B 272
PHE B 277
PRO B 292
GLN B  81
ASP B 279
None
1.30A22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens)		5 / 12SER A 823
LEU A 761
PHE A 885
ASP A 753
GLY A 755
None
None
None
SO4  A 910 ( 4.1A)
None
1.50A25.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		3rbl AROMATIC L-AMINO
ACID DECARBOXYLASE
(Homo
sapiens)		5 / 12SER A 108
CYH A 111
PHE A 357
ASP A  92
GLY A  96
None
1.34A21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		4hxq ARGINASE-1
(Homo
sapiens)		5 / 12SER A  94
LEU A  95
ALA A 104
MET A 276
GLY A  99
None
1.34A20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		4l59 LETHAL(3)MALIGNANT
BRAIN TUMOR-LIKE
PROTEIN 3
(Homo
sapiens)		5 / 12SER A 420
CYH A 416
PHE A 401
TYR A 414
ALA A 391
None
1.19A21.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		4z3k SEPIAPTERIN
REDUCTASE
(Homo
sapiens)		11 / 12SER A 154
CYH A 156
PHE A 161
TRP A 164
TYR A 167
PRO A 197
GLN A 203
ALA A 206
ASP A 214
MET A 215
GLY A 218
4KL  A 802 (-2.6A)
4KL  A 802 ( 4.2A)
None
None
4KL  A 802 ( 4.1A)
4KL  A 802 (-4.0A)
4KL  A 802 ( 3.2A)
4KL  A 802 ( 4.3A)
None
None
None
0.63A94.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		4z3k SEPIAPTERIN
REDUCTASE
(Homo
sapiens)		7 / 12SER A 154
LEU A 155
CYH A 156
PHE A 161
PRO A 197
GLN A 203
ASP A 212
4KL  A 802 (-2.6A)
4KL  A 802 (-4.0A)
4KL  A 802 ( 4.2A)
None
4KL  A 802 (-4.0A)
4KL  A 802 ( 3.2A)
None
1.08A94.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		4z3k SEPIAPTERIN
REDUCTASE
(Homo
sapiens)		11 / 12SER A 154
LEU A 155
CYH A 156
PHE A 161
TRP A 164
TYR A 167
PRO A 197
GLN A 203
ALA A 206
MET A 215
GLY A 218
4KL  A 802 (-2.6A)
4KL  A 802 (-4.0A)
4KL  A 802 ( 4.2A)
None
None
4KL  A 802 ( 4.1A)
4KL  A 802 (-4.0A)
4KL  A 802 ( 3.2A)
4KL  A 802 ( 4.3A)
None
None
0.56A94.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		5uu1 SERINE/THREONINE-PRO
TEIN KINASE VRK2
(Homo
sapiens)		5 / 12SER A 190
TYR A 162
ALA A  81
ASP A 152
GLY A  99
None
1.19A23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		1f45 INTERLEUKIN-12 ALPHA
CHAIN
(Homo
sapiens)		5 / 12LEU B 177
TYR B 112
ALA B 184
MET B  29
LEU B  30
None
1.23A21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		2ad1 SULFOTRANSFERASE 1C2
(Homo
sapiens)		5 / 12LEU A 164
PHE A 160
TRP A 156
TYR A 159
PRO A 133
None
1.07A21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		2rhz LETHAL(3)MALIGNANT
BRAIN TUMOR-LIKE
PROTEIN
(Homo
sapiens)		5 / 12SER A 394
CYH A 390
PHE A 375
TYR A 388
ALA A 365
None
1.16A20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		3f5o THIOESTERASE
SUPERFAMILY MEMBER 2
(Homo
sapiens)		5 / 12LEU A  73
GLN A 109
ALA A 114
GLY A 139
LEU A 138
None
None
None
COA  A 150 (-3.3A)
None
1.18A21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct)		5 / 12LEU A3583
PHE A3693
ALA A3572
GLY A3699
LEU A3698
None
1.30A6.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		4z3k SEPIAPTERIN
REDUCTASE
(Homo
sapiens)		12 / 12SER A 154
LEU A 155
CYH A 156
PHE A 161
TRP A 164
TYR A 167
PRO A 197
GLN A 203
ALA A 206
MET A 215
GLY A 218
LEU A 219
4KL  A 802 (-2.6A)
4KL  A 802 (-4.0A)
4KL  A 802 ( 4.2A)
None
None
4KL  A 802 ( 4.1A)
4KL  A 802 (-4.0A)
4KL  A 802 ( 3.2A)
4KL  A 802 ( 4.3A)
None
None
4KL  A 802 (-4.9A)
0.47A94.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens)		5 / 12CYH A1586
GLN A1262
MET A1373
GLY A1308
LEU A1307
None
1.29A9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		5myv SRSF PROTEIN KINASE
2,SRSF PROTEIN
KINASE 2
(Homo
sapiens)		5 / 12SER A 146
CYH A 219
TYR A 214
GLY A 543
LEU A 542
None
None
None
None
DMS  A 717 (-4.0A)
1.13A20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		1fyh INTERFERON GAMMA
(Homo
sapiens)		3 / 3LEU A  95
MET A 245
ASP A 111
None
0.74A21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		1q8m TRIGGERING RECEPTOR
EXPRESSED ON MYELOID
CELLS 1
(Homo
sapiens)		3 / 3LEU A  37
MET A 100
ASP A  42
None
0.75A16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		1t6n PROBABLE
ATP-DEPENDENT RNA
HELICASE
(Homo
sapiens)		3 / 3LEU A 187
MET A 217
ASP A 196
None
0.82A19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		2je1 ACIDIC LEUCINE-RICH
NUCLEAR
PHOSPHOPROTEIN 32
FAMILY MEMBER A
(Homo
sapiens)		3 / 3LEU A  24
MET A   3
ASP A  18
None
0.57A21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		2mgs C-X-C MOTIF
CHEMOKINE 5
(Homo
sapiens)		3 / 3LEU A  48
MET A  26
ASP A  57
None
0.63A15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		2rqa ATP-DEPENDENT RNA
HELICASE DHX58
(Homo
sapiens)		3 / 3LEU A 554
MET A 638
ASP A 661
None
0.80A19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		2v7c ORPHAN NUCLEAR
RECEPTOR NR1D2
(Homo
sapiens)		3 / 3LEU A 482
MET A 486
ASP A 515
None
0.81A22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		3eh1 PROTEIN TRANSPORT
PROTEIN SEC24B
(Homo
sapiens)		3 / 3LEU A1021
MET A1025
ASP A 947
None
0.80A18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		3eo2 NEUROEPITHELIAL
CELL-TRANSFORMING
GENE 1 PROTEIN
(Homo
sapiens)		3 / 3LEU A 321
MET A 182
ASP A 309
None
0.81A26.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		4fgu LEGUMAIN
(Homo
sapiens)		3 / 3LEU A 246
MET A 286
ASP A  48
None
0.67A20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		4js1 BETA-GALACTOSIDE
ALPHA-2,6-SIALYLTRAN
SFERASE 1
(Homo
sapiens)		3 / 3LEU A 209
MET A 331
ASP A 258
None
0.79A23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens)		3 / 3LEU A 243
MET A 257
ASP A 278
None
None
29X  A 702 ( 4.8A)
0.74A19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		4pwn SERINE/THREONINE-PRO
TEIN KINASE WNK1
(Homo
sapiens)		3 / 3LEU A 324
MET A 319
ASP A 445
None
0.68A22.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		4z3k SEPIAPTERIN
REDUCTASE
(Homo
sapiens)		3 / 3LEU A 101
MET A 202
ASP A 214
None
NAP  A 801 (-3.5A)
None
0.20A94.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		5uuu BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens)		3 / 3LEU A 243
MET A 257
ASP A 278
None
0.83A22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		5yz0 SERINE/THREONINE-PRO
TEIN KINASE ATR
(Homo
sapiens)		3 / 3LEU A1910
MET A1856
ASP A1815
None
0.77A14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		6bf6 INSULIN-DEGRADING
ENZYME
(Homo
sapiens)		3 / 3LEU A 559
MET A 742
ASP A 564
None
0.81A13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		2ad1 SULFOTRANSFERASE 1C2
(Homo
sapiens)		5 / 12LEU A 164
PHE A 160
TRP A 156
TYR A 159
PRO A 133
None
1.07A21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		2i7d 5'(3')-DEOXYRIBONUCL
EOTIDASE, CYTOSOLIC
TYPE
(Homo
sapiens)		5 / 12LEU A 102
CYH A 108
PHE A  71
ASP A  17
GLY A  13
DUR  A 300 (-4.7A)
None
None
None
MG  A 728 ( 4.5A)
1.19A22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		2o2k METHIONINE SYNTHASE
(Homo
sapiens)		5 / 12PHE A1220
TYR A1227
PRO A1175
ASP A1084
GLY A1064
None
1.37A23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		2qob EPHRIN RECEPTOR
(Homo
sapiens)		5 / 12SER A 809
LEU A 747
PHE A 871
ASP A 739
GLY A 741
None
1.43A21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens)		5 / 12SER A 863
LEU A 801
PHE A 925
ASP A 793
GLY A 795
None
1.45A20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		2ybx PHOSPHATIDYLINOSITOL
-5-PHOSPHATE
4-KINASE TYPE-2
ALPHA
(Homo
sapiens)		5 / 12PHE A 112
GLN A 177
ASP A 111
ASP A 108
GLY A 106
None
1.49A19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens)		5 / 12SER A 821
LEU A 759
PHE A 883
ASP A 751
GLY A 753
None
1.42A22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		3fhc ATP-DEPENDENT RNA
HELICASE DDX19B
(Homo
sapiens)		5 / 12LEU B 272
PHE B 277
PRO B 292
GLN B  81
ASP B 279
None
1.29A22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		3rbl AROMATIC L-AMINO
ACID DECARBOXYLASE
(Homo
sapiens)		5 / 12SER A 108
CYH A 111
PHE A 357
ASP A  92
GLY A  96
None
1.32A21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		4fo0 ACTIN-RELATED
PROTEIN 8
(Homo
sapiens)		5 / 12LEU A 346
PHE A 318
TYR A 319
PRO A 328
ASP A 383
None
1.36A20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		4hxq ARGINASE-1
(Homo
sapiens)		5 / 12SER A  94
LEU A  95
ASP A 232
MET A 276
GLY A  99
None
None
MN  A 902 (-3.0A)
None
None
1.24A20.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		4z3k SEPIAPTERIN
REDUCTASE
(Homo
sapiens)		12 / 12SER A 154
LEU A 155
CYH A 156
PHE A 161
TRP A 164
TYR A 167
PRO A 197
GLN A 203
ASP A 212
ASP A 214
MET A 215
GLY A 218
4KL  A 802 (-2.6A)
4KL  A 802 (-4.0A)
4KL  A 802 ( 4.2A)
None
None
4KL  A 802 ( 4.1A)
4KL  A 802 (-4.0A)
4KL  A 802 ( 3.2A)
None
None
None
None
0.69A94.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		4z3k SEPIAPTERIN
REDUCTASE
(Homo
sapiens)		6 / 12SER A 154
LEU A 155
PHE A 161
PRO A 197
GLN A 203
ASP A 212
4KL  A 802 (-2.6A)
4KL  A 802 (-4.0A)
None
4KL  A 802 (-4.0A)
4KL  A 802 ( 3.2A)
None
1.16A94.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		6au8 GOLGI TO ER TRAFFIC
PROTEIN 4 HOMOLOG
LARGE PROLINE-RICH
PROTEIN BAG6
(Homo
sapiens)		5 / 12SER C1038
LEU C1037
TYR A 182
GLN A 202
ASP A 193
None
None
None
GOL  A 401 ( 3.3A)
None
1.27A8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_J_SASJ804_1
(SEPIAPTERIN
REDUCTASE)		2ad1 SULFOTRANSFERASE 1C2
(Homo
sapiens)		5 / 12LEU A 164
PHE A 160
TRP A 156
TYR A 159
PRO A 133
None
1.08A21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_J_SASJ804_1
(SEPIAPTERIN
REDUCTASE)		3fhc ATP-DEPENDENT RNA
HELICASE DDX19B
(Homo
sapiens)		5 / 12LEU B 272
PHE B 277
PRO B 292
GLN B  81
ASP B 279
None
1.35A22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_J_SASJ804_1
(SEPIAPTERIN
REDUCTASE)		4fo0 ACTIN-RELATED
PROTEIN 8
(Homo
sapiens)		5 / 12LEU A 346
PHE A 318
TYR A 319
PRO A 328
ASP A 383
None
1.32A20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_J_SASJ804_1
(SEPIAPTERIN
REDUCTASE)		4m7f FIBRINOGEN C
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens)		5 / 12LEU A 323
TYR A 329
PRO A 241
ASP A 274
ASP A 255
None
1.42A19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_J_SASJ804_1
(SEPIAPTERIN
REDUCTASE)		4nen INTEGRIN BETA-2
(Homo
sapiens)		5 / 12LEU B 333
LEU B 110
PRO B 296
ASP B 242
ASP B 243
None
None
None
CA  B 706 ( 3.4A)
None
1.19A18.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4J7X_J_SASJ804_1
(SEPIAPTERIN
REDUCTASE)		4z3k SEPIAPTERIN
REDUCTASE
(Homo
sapiens)		6 / 12LEU A 101
CYH A 168
PHE A 161
TRP A 164
ASP A 212
MET A 215
None
1.44A94.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4J7X_J_SASJ804_1
(SEPIAPTERIN
REDUCTASE)		4z3k SEPIAPTERIN
REDUCTASE
(Homo
sapiens)		12 / 12LEU A 101
SER A 154
LEU A 155
CYH A 156
PHE A 161
TRP A 164
TYR A 167
PRO A 197
GLN A 203
ASP A 212
ASP A 214
MET A 215
None
4KL  A 802 (-2.6A)
4KL  A 802 (-4.0A)
4KL  A 802 ( 4.2A)
None
None
4KL  A 802 ( 4.1A)
4KL  A 802 (-4.0A)
4KL  A 802 ( 3.2A)
None
None
None
0.60A94.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4J7X_J_SASJ804_1
(SEPIAPTERIN
REDUCTASE)		4z3k SEPIAPTERIN
REDUCTASE
(Homo
sapiens)		6 / 12SER A 154
LEU A 155
PHE A 161
PRO A 197
GLN A 203
ASP A 212
4KL  A 802 (-2.6A)
4KL  A 802 (-4.0A)
None
4KL  A 802 (-4.0A)
4KL  A 802 ( 3.2A)
None
1.05A94.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_J_SASJ804_1
(SEPIAPTERIN
REDUCTASE)		5e6s INTEGRIN BETA-2
(Homo
sapiens)		5 / 12LEU B 333
LEU B 110
PRO B 296
ASP B 242
ASP B 243
None
1.18A19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_J_SASJ804_1
(SEPIAPTERIN
REDUCTASE)		5o1p ALPHA-AMINOADIPIC
SEMIALDEHYDE
SYNTHASE,
MITOCHONDRIAL
(Homo
sapiens)		5 / 12LEU A 583
SER A 552
LEU A 553
PRO A 555
ASP A 604
None
1.48A22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_J_SASJ804_1
(SEPIAPTERIN
REDUCTASE)		6au8 GOLGI TO ER TRAFFIC
PROTEIN 4 HOMOLOG
LARGE PROLINE-RICH
PROTEIN BAG6
(Homo
sapiens)		5 / 12LEU A 179
SER C1038
LEU C1037
TYR A 182
GLN A 202
None
None
None
None
GOL  A 401 ( 3.3A)
1.43A22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_J_SASJ804_1
(SEPIAPTERIN
REDUCTASE)		6au8 GOLGI TO ER TRAFFIC
PROTEIN 4 HOMOLOG
LARGE PROLINE-RICH
PROTEIN BAG6
(Homo
sapiens)		5 / 12SER C1038
LEU C1037
TYR A 182
GLN A 202
ASP A 193
None
None
None
GOL  A 401 ( 3.3A)
None
1.25A8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ACL_A_SASA1111_1
(MCG)		1b4j ANTIBODY
(Homo
sapiens)		4 / 7TYR L  32
SER L  34
TYR L  36
PHE L  96
None
0.96A26.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ACL_A_SASA1111_1
(MCG)		1b4j ANTIBODY
(Homo
sapiens)		4 / 7TYR L  32
SER L  34
TYR L  36
TYR L  49
None
0.78A26.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ACL_A_SASA1111_1
(MCG)		1mcw IMMUNOGLOBULIN WEIR
(LIGHT CHAIN)
(Homo
sapiens)		4 / 7SER W  36
TYR W  51
PRO W  57
PHE W  99
None
1.13A66.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ACL_A_SASA1111_1
(MCG)		1pw3 IMMUNOGLOBULIN
LAMBDA CHAIN
VARIABLE REGION
(Homo
sapiens)		5 / 7TYR A  32
TYR A  36
TYR A  49
GLU A  50
PRO A  55
None
0.76A60.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ACL_A_SASA1111_1
(MCG)		2a9m FLUORESCEIN-SCFV
HEAVY CHAIN
FLUORESCEIN-SCFV
LIGHT CHAIN
(Homo
sapiens)		4 / 7TYR H 133
TYR L  44
TYR L  57
PRO L  71
None
0.82A31.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ACL_A_SASA1111_1
(MCG)		2a9m FLUORESCEIN-SCFV
LIGHT CHAIN
(Homo
sapiens)		4 / 7TYR L  40
TYR L  44
TYR L  57
PRO L  71
None
0.87A70.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ACL_A_SASA1111_1
(MCG)		2dn4 GENERAL
TRANSCRIPTION FACTOR
II-I
(Homo
sapiens)		4 / 7TYR A  45
GLU A  47
PRO A  50
PHE A  37
None
1.17A23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ACL_A_SASA1111_1
(MCG)		2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens)		4 / 7TYR A 523
SER A 526
GLU A 411
PHE A 457
3ES  A1635 (-3.4A)
None
ZN  A1628 ( 2.4A)
3ES  A1635 (-4.1A)
0.97A11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ACL_A_SASA1111_1
(MCG)		2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens)		4 / 7TYR A 501
SER A 504
GLU A 389
PHE A 435
3ES  A1611 (-3.5A)
None
ZN  A1620 ( 2.4A)
3ES  A1611 ( 4.2A)
1.07A11.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ACL_A_SASA1111_1
(MCG)		3go1 FAB 268-D, LIGHT
CHAIN
(Homo
sapiens)		4 / 7TYR L  32
TYR L  36
TYR L  49
PRO L  55
None
0.53A56.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ACL_A_SASA1111_1
(MCG)		3mlu HUMAN MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY 2557 FAB
LIGHT CHAIN
(Homo
sapiens)		5 / 7TYR L  32
SER L  34
TYR L  36
TYR L  49
PRO L  55
None
0.68A50.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ACL_A_SASA1111_1
(MCG)		3nps S4 FAB LIGHT CHAIN
(Homo
sapiens)		5 / 7TYR C  32
SER C  34
TYR C  36
TYR C  49
PRO C  55
None
0.70A65.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ACL_A_SASA1111_1
(MCG)		3p30 1281 FAB LIGHT CHAIN
(Homo
sapiens)		4 / 7TYR L  32
TYR L  36
TYR L  49
PRO L  55
None
0.51A66.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ACL_A_SASA1111_1
(MCG)		3ux9 SCFV ANTIBODY
(Homo
sapiens)		5 / 7TYR B  35
SER B  37
TYR B  39
TYR B  52
PRO B  58
None
0.78A31.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ACL_A_SASA1111_1
(MCG)		3wlw ANTIBODY L CHAIN
(Homo
sapiens)		5 / 7TYR L  34
SER L  36
TYR L  38
TYR L  51
PRO L  57
None
0.70A82.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ACL_A_SASA1111_1
(MCG)		3wu1 PROTEIN C-ETS-1
(Homo
sapiens)		4 / 7SER B 390
TYR B 412
GLU B 387
PRO B 368
None
1.01A23.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ACL_A_SASA1111_1
(MCG)		3zl4 A17 ANTIBODY FAB
FRAGMENT LAMBDA
LIGHT CHAIN
(Homo
sapiens)		4 / 7TYR L  33
SER L  35
TYR L  37
PRO L  56
None
MES  L1217 ( 3.9A)
None
None
1.07A66.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ACL_A_SASA1111_1
(MCG)		3zl4 A17 ANTIBODY FAB
FRAGMENT LAMBDA
LIGHT CHAIN
(Homo
sapiens)		4 / 7TYR L  33
TYR L  37
TYR L  50
PRO L  56
None
0.76A66.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ACL_A_SASA1111_1
(MCG)		4aiz V2-17 PROTEIN
(Homo
sapiens)		4 / 7TYR A  31
TYR A  35
TYR A  48
PRO A  54
None
0.66A54.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ACL_A_SASA1111_1
(MCG)		4bqa PROTEIN C-ETS-2
(Homo
sapiens)		4 / 7SER A 418
TYR A 440
GLU A 415
PRO A 396
None
1.05A18.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ACL_A_SASA1111_1
(MCG)		4buh CLONE M0418 SCFV
(Homo
sapiens)		4 / 7TYR A 110
TYR A 178
TYR A 191
PRO A 197
None
None
EDO  A1254 ( 4.0A)
EDO  A1254 ( 4.5A)
0.95A40.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ACL_A_SASA1111_1
(MCG)		4n2c PROTEIN-ARGININE
DEIMINASE TYPE-2
(Homo
sapiens)		4 / 7TYR A 392
GLU A 165
PRO A 381
PHE A 365
None
1.15A10.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ACL_A_SASA1111_1
(MCG)		4nik SINGLE-CHAIN FV
FRAGMENT ANTIBODY
(Homo
sapiens)		6 / 7TYR B 168
SER B 170
TYR B 172
TYR B 185
GLU B 186
PRO B 191
None
0.60A37.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ACL_A_SASA1111_1
(MCG)		4qf1 INFERRED UNMUTATED
ANCESTOR (UA) OF
ANTI-HIV ANTIBODY
CH59
(Homo
sapiens)		5 / 7TYR L  32
TYR L  36
TYR L  49
GLU L  50
PRO L  55
None
0.81A57.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ACL_A_SASA1111_1
(MCG)		4rav SINGLE-CHAIN FV, VH
SINGLE-CHAIN FV, VL
(Homo
sapiens)		4 / 7TYR B 161
SER B 163
TYR B 165
TYR A 101
None
0.85A75.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ACL_A_SASA1111_1
(MCG)		4rav SINGLE-CHAIN FV, VL
(Homo
sapiens)		5 / 7TYR B 161
SER B 163
TYR B 165
TYR B 178
PRO B 184
None
0.48A75.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ACL_A_SASA1111_1
(MCG)		4unu IG LAMBDA CHAIN V-II
REGION MGC
(Homo
sapiens)		7 / 7TYR A  34
SER A  36
TYR A  38
TYR A  51
GLU A  52
PRO A  57
PHE A  99
15P  A1111 (-3.5A)
15P  A1111 ( 4.4A)
None
15P  A1111 (-3.4A)
None
None
None
0.41A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ACL_A_SASA1111_1
(MCG)		4ut7 BROADLY NEUTRALIZING
HUMAN ANTIBODY EDE2
A11
(Homo
sapiens)		4 / 7SER L  34
TYR L  36
TYR L  49
PRO L  55
None
0.66A69.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ACL_A_SASA1111_1
(MCG)		4ut7 BROADLY NEUTRALIZING
HUMAN ANTIBODY EDE2
A11
(Homo
sapiens)		4 / 7TYR L  36
TYR L  49
GLU L  50
PRO L  55
None
0.20A69.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ACL_A_SASA1111_1
(MCG)		4y5x DIABODY 310 VH
DOMAIN
DIABODY 310 VL
DOMAIN
(Homo
sapiens)		4 / 7TYR A 109
TYR B  37
TYR B  50
PRO B  56
None
0.80A31.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ACL_A_SASA1111_1
(MCG)		4yjz SCFV H2526
(Homo
sapiens)		4 / 7TYR L 313
TYR L  37
TYR L  50
PRO L  56
None
1.05A65.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ACL_A_SASA1111_1
(MCG)		4z0x ANTIBODY HC26AM
LIGHT CHAIN VARIABLE
DOMAIN
(Homo
sapiens)		5 / 7TYR A  31
SER A  33
TYR A  35
TYR A  48
PRO A  54
None
0.67A57.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ACL_A_SASA1111_1
(MCG)		4zwj CHIMERA PROTEIN OF
HUMAN RHODOPSIN,
MOUSE S-ARRESTIN,
AND T4 ENDOLYSIN
(Escherichia
virus
T4;
Homo
sapiens;
Mus
musculus)		4 / 7TYR A  30
TYR A  26
GLU A  25
PHE A   9
None
1.17A14.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ACL_A_SASA1111_1
(MCG)		5ado FAB A.17
(Homo
sapiens)		4 / 7TYR L  33
TYR L  37
TYR L  50
PRO L  56
None
DEP  L1356 (-4.0A)
None
None
0.56A35.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ACL_A_SASA1111_1
(MCG)		5awn LIGHT CHAIN OF
3BC176 FAB
(Homo
sapiens)		5 / 7SER L  34
TYR L  36
TYR L  49
GLU L  50
PRO L  55
None
0.62A68.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ACL_A_SASA1111_1
(MCG)		5f89 CAP248-2B LIGHT
CHAIN
(Homo
sapiens)		5 / 7TYR L  32
SER L  34
TYR L  36
TYR L  49
PRO L  55
None
0.73A71.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ACL_A_SASA1111_1
(MCG)		5fcs DIABODY
(Homo
sapiens)		5 / 7TYR L  33
SER L  35
TYR L  37
TYR L  50
PRO L  56
None
0.61A64.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ACL_A_SASA1111_1
(MCG)		5grj AVELUMAB L CHAIN
(Homo
sapiens)		4 / 7SER L  36
TYR L  38
TYR L  51
PRO L  57
None
0.75A83.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ACL_A_SASA1111_1
(MCG)		5jo5 10E8 GLV
(Homo
sapiens)		4 / 7SER L  34
TYR L  36
TYR L  49
PRO L  55
None
0.68A63.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ACL_A_SASA1111_1
(MCG)		5jo5 10E8 GLV
(Homo
sapiens)		4 / 7TYR L  32
TYR L  36
TYR L  49
PRO L  55
None
1.18A63.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ACL_A_SASA1111_1
(MCG)		5jz7 MEDI578 SCFV, LIGHT
CHAIN
(Homo
sapiens)		5 / 7TYR D  32
SER D  34
TYR D  36
TYR D  49
PRO D  55
None
0.73A63.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ACL_A_SASA1111_1
(MCG)		5odb D10 FAB FRAGMENT -
LIGHT CHAIN
(Homo
sapiens)		4 / 7TYR B  32
TYR B  36
TYR B  49
PRO B  55
None
None
None
SO4  B 301 (-4.6A)
0.55A56.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ACL_A_SASA1111_1
(MCG)		5u0r DH270.UCA1 LIGHT
CHAIN
(Homo
sapiens)		5 / 7SER L  36
TYR L  38
TYR L  51
GLU L  52
PRO L  57
None
0.35A80.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ACL_A_SASA1111_1
(MCG)		5u0u DH270.1 SINGLE-CHAIN
VARIABLE FRAGMENT
(Homo
sapiens)		6 / 7TYR G 111
SER G 175
TYR G 177
TYR G 190
GLU G 191
PRO G 196
None
1.06A78.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ACL_A_SASA1111_1
(MCG)		5xcv VL-SARAH(S37C)
CHIMERA,VL-SARAH(S37
C) CHIMERA
(Homo
sapiens;
Rattus)		4 / 7TYR B  32
TYR B  36
TYR B  49
PRO B  55
None
0.47A55.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ACL_A_SASA1111_1
(MCG)		5y7y ARYL HYDROCARBON
RECEPTOR REPRESSOR
(Homo
sapiens)		4 / 7SER A  76
TYR A  77
PRO A  56
PHE A 137
None
1.11A16.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ACL_A_SASA1111_1
(MCG)		5yax SCFV1 ANTIBODY
(Homo
sapiens)		4 / 7TYR A1038
TYR A1042
TYR A1055
PRO A1068
None
0.57A31.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ACL_A_SASA1111_1
(MCG)		6cbp DH270.6 SINGLE CHAIN
VARIABLE FRAGMENT
(Homo
sapiens)		6 / 7TYR A 111
SER A 178
TYR A 180
TYR A 193
GLU A 194
PRO A 199
MAN  A 304 ( 4.5A)
None
None
MAN  A 305 ( 3.8A)
MAN  A 304 ( 2.7A)
MAN  A 306 ( 4.5A)
1.10A21.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ACL_A_SASA1111_1
(MCG)		6ck9 35O22 SCFV LIGHT
CHAIN PORTION
(Homo
sapiens)		4 / 7SER E  34
TYR E  36
TYR E  49
GLU E  50
None
0.83A46.94