POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGL_A_RZXA257_1
(CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 1)		1d1z SAP SH2 DOMAIN
(Homo
sapiens)		4 / 7ASP A1033
VAL A1004
ILE A1084
TYR A1007
None
0.99A16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGL_A_RZXA257_1
(CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 1)		1o6u SEC14-LIKE PROTEIN 2
(Homo
sapiens)		4 / 7ASP A 235
VAL A  98
ILE A 152
SER A 233
None
0.96A18.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PGL_A_RZXA257_1
(CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 1)		2hhl CTD SMALL
PHOSPHATASE-LIKE
PROTEIN
(Homo
sapiens)		4 / 7ASP A  36
PHE A  44
SER A  92
TYR A  96
None
KEG  A 902 (-3.8A)
None
None
0.81A75.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PGL_A_RZXA257_1
(CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 1)		2hhl CTD SMALL
PHOSPHATASE-LIKE
PROTEIN
(Homo
sapiens)		5 / 7ASP A  36
VAL A  56
ILE A  58
SER A  92
TYR A  96
None
0.59A75.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PGL_A_RZXA257_1
(CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 1)		2q5e CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 2
(Homo
sapiens)		5 / 7ASP A 109
PHE A 117
ILE A 131
SER A 165
TYR A 169
None
0.81A75.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PGL_A_RZXA257_1
(CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 1)		2q5e CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 2
(Homo
sapiens)		4 / 7ASP A 109
SER A 165
TYR A 169
ARG A 189
None
0.83A75.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGL_A_RZXA257_1
(CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 1)		3fq4 INTEGRIN BETA-4
(Homo
sapiens)		4 / 7ASP A1030
VAL A1059
ILE A1010
TYR A1039
None
0.92A22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGL_A_RZXA257_1
(CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 1)		3iu6 PROTEIN POLYBROMO-1
(Homo
sapiens)		4 / 7PHE A 808
VAL A 797
ILE A 793
SER A 756
None
0.95A24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGL_A_RZXA257_1
(CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 1)		3uj1 THIOREDOXIN
DOMAIN-CONTAINING
PROTEIN 5
(Homo
sapiens)		4 / 7PHE A 332
VAL A 379
ILE A 343
SER A 389
None
0.97A19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGL_A_RZXA257_1
(CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 1)		3v4y NUCLEAR INHIBITOR OF
PROTEIN PHOSPHATASE
1
SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PP1-ALPHA CATALYTIC
SUBUNIT
(Homo
sapiens)		4 / 7ASP B 207
PHE B 203
VAL A 264
TYR A 255
None
0.91A14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGL_A_RZXA257_1
(CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 1)		4ay2 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX58
(Homo
sapiens)		4 / 7PHE A 853
VAL A 877
ILE A 875
TYR A 879
None
0.92A13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGL_A_RZXA257_1
(CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 1)		4omj SEC14-LIKE PROTEIN 2
(Homo
sapiens)		4 / 7ASP A 235
VAL A  98
ILE A 152
SER A 233
None
0.87A20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGL_A_RZXA257_1
(CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 1)		4qtb MITOGEN-ACTIVATED
PROTEIN KINASE 3
(Homo
sapiens)		5 / 7PHE A 185
VAL A 100
ILE A 182
SER A 159
TYR A 156
None
1.42A20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGL_A_RZXA257_1
(CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 1)		4yd8 PROTEIN PTHB1
(Homo
sapiens)		4 / 7ASP A 236
VAL A 260
ILE A 248
SER A 192
None
0.95A20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGL_A_RZXA257_1
(CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 1)		5kqv INSULIN
RECEPTOR,INSULIN
RECEPTOR
(Homo
sapiens)		4 / 7ASP E 142
ILE E  95
SER E 116
TYR E  91
None
0.97A14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGL_A_RZXA257_1
(CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 1)		5m23 WD REPEAT-CONTAINING
PROTEIN 5
(Homo
sapiens)		4 / 7ASP A 280
ILE A 316
SER A 278
TYR A 284
None
0.84A18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGL_A_RZXA257_1
(CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 1)		6byn WD REPEAT-CONTAINING
PROTEIN 5
(Homo
sapiens)		4 / 7ASP W 280
ILE W 316
SER W 278
TYR W 284
None
0.87A21.26