POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		2pqf POLY [ADP-RIBOSE]
POLYMERASE 12
(Homo
sapiens)		6 / 8HIS A 564
GLY A 565
TYR A 596
ALA A 598
SER A 604
TYR A 607
GAB  A 701 ( 3.7A)
GAB  A 701 (-3.6A)
GAB  A 701 (-4.5A)
GAB  A 701 (-3.3A)
GAB  A 701 (-2.8A)
GAB  A 701 (-3.3A)
0.29A28.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		3c49 POLY(ADP-RIBOSE)
POLYMERASE 3
(Homo
sapiens)		7 / 8HIS A 384
GLY A 385
ALA A 416
LYS A 421
SER A 422
TYR A 425
GLU A 514
KU8  A 601 (-4.0A)
KU8  A 601 (-3.5A)
KU8  A 601 ( 4.0A)
KU8  A 601 (-4.3A)
KU8  A 601 (-2.9A)
KU8  A 601 (-3.5A)
KU8  A 601 (-3.9A)
0.90A23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		3c49 POLY(ADP-RIBOSE)
POLYMERASE 3
(Homo
sapiens)		7 / 8HIS A 384
GLY A 385
TYR A 414
ALA A 416
LYS A 421
SER A 422
TYR A 425
KU8  A 601 (-4.0A)
KU8  A 601 (-3.5A)
KU8  A 601 (-4.1A)
KU8  A 601 ( 4.0A)
KU8  A 601 (-4.3A)
KU8  A 601 (-2.9A)
KU8  A 601 (-3.5A)
0.55A23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		3hkv POLY [ADP-RIBOSE]
POLYMERASE 10
(Homo
sapiens)		6 / 8HIS A 887
GLY A 888
TYR A 919
ALA A 921
SER A 927
TYR A 932
3AB  A1025 (-3.8A)
3AB  A1025 (-3.5A)
3AB  A1025 (-4.4A)
3AB  A1025 ( 3.9A)
3AB  A1025 (-2.8A)
3AB  A1025 (-3.7A)
0.30A24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		3wsy SORTILIN-RELATED
RECEPTOR
(Homo
sapiens)		4 / 8HIS A 476
GLY A 511
ALA A 515
GLU A 436
None
0.88A15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		4c2k 3-KETOACYL-COA
THIOLASE,
MITOCHONDRIAL
(Homo
sapiens)		5 / 8HIS A 222
GLY A 252
ALA A 347
SER A 251
GLU A 321
None
MES  A1401 (-3.5A)
None
None
None
1.49A20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		4f0d POLY [ADP-RIBOSE]
POLYMERASE 16
(Homo
sapiens)		4 / 8HIS A 152
GLY A 153
TYR A 182
TYR A 193
3AB  A 301 (-4.0A)
3AB  A 301 (-3.4A)
3AB  A 301 (-4.3A)
3AB  A 301 (-3.8A)
0.33A23.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		4f0e POLY [ADP-RIBOSE]
POLYMERASE 15
(Homo
sapiens)		6 / 8HIS A 537
GLY A 538
TYR A 569
ALA A 571
SER A 577
TYR A 582
0RU  A 701 (-3.7A)
0RU  A 701 (-3.3A)
0RU  A 701 (-4.3A)
None
0RU  A 701 (-3.5A)
0RU  A 701 (-3.7A)
0.39A30.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		4l2k TANKYRASE-2
(Homo
sapiens)		7 / 8HIS A1031
GLY A1032
TYR A1060
ALA A1062
LYS A1067
SER A1068
TYR A1071
1V8  A1201 (-4.2A)
1V8  A1201 (-3.7A)
1V8  A1201 (-4.7A)
1V8  A1201 (-3.6A)
SO4  A1203 ( 2.8A)
1V8  A1201 (-2.7A)
1V8  A1201 (-3.3A)
0.18A100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		4nwy PROTEIN
DISULFIDE-ISOMERASE-
LIKE PROTEIN OF THE
TESTIS
(Homo
sapiens)		4 / 8HIS A 295
ALA A 299
LYS A 360
GLU A 302
None
0.78A22.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		4oa7 TANKYRASE-1
(Homo
sapiens)		6 / 8HIS A1184
GLY A1185
ALA A1215
LYS A1220
SER A1221
TYR A1224
2XS  A1402 (-4.2A)
None
None
None
None
2XS  A1402 ( 3.9A)
0.88A79.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		4oa7 TANKYRASE-1
(Homo
sapiens)		6 / 8HIS A1184
GLY A1185
TYR A1213
ALA A1215
SER A1221
TYR A1224
2XS  A1402 (-4.2A)
None
2XS  A1402 (-4.2A)
None
None
2XS  A1402 ( 3.9A)
0.60A79.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		4oqa POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens)		6 / 8HIS C 862
GLY C 863
ALA C 898
LYS C 903
SER C 904
GLU C 988
2US  C1101 (-3.7A)
2US  C1101 (-3.3A)
2US  C1101 (-3.5A)
2US  C1101 ( 4.8A)
2US  C1101 (-3.4A)
2US  C1101 (-3.2A)
1.36A18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		4oqa POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens)		6 / 8HIS C 862
GLY C 863
ALA C 898
SER C 904
TYR C 907
GLU C 988
2US  C1101 (-3.7A)
2US  C1101 (-3.3A)
2US  C1101 (-3.5A)
2US  C1101 (-3.4A)
2US  C1101 (-3.5A)
2US  C1101 (-3.2A)
0.81A18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		4oqa POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens)		6 / 8HIS C 862
GLY C 863
TYR C 896
ALA C 898
LYS C 903
SER C 904
2US  C1101 (-3.7A)
2US  C1101 (-3.3A)
2US  C1101 (-4.2A)
2US  C1101 (-3.5A)
2US  C1101 ( 4.8A)
2US  C1101 (-3.4A)
0.93A18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		4oqa POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens)		6 / 8HIS C 862
GLY C 863
TYR C 896
ALA C 898
SER C 904
TYR C 907
2US  C1101 (-3.7A)
2US  C1101 (-3.3A)
2US  C1101 (-4.2A)
2US  C1101 (-3.5A)
2US  C1101 (-3.4A)
2US  C1101 (-3.5A)
0.44A18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		4py4 POLY [ADP-RIBOSE]
POLYMERASE 14
(Homo
sapiens)		6 / 8HIS A1682
GLY A1683
TYR A1714
ALA A1716
SER A1722
TYR A1727
XL2  A1901 (-4.0A)
XL2  A1901 (-3.6A)
XL2  A1901 (-3.7A)
XL2  A1901 (-3.4A)
XL2  A1901 (-2.6A)
XL2  A1901 (-3.6A)
0.29A26.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		4zzy POLY [ADP-RIBOSE]
POLYMERASE 2
(Homo
sapiens)		6 / 8HIS A 428
GLY A 429
ALA A 464
SER A 470
TYR A 473
GLU A 558
D7N  A1584 (-3.6A)
D7N  A1584 (-3.8A)
D7N  A1584 (-3.2A)
D7N  A1584 (-2.7A)
D7N  A1584 (-3.8A)
D7N  A1584 (-3.9A)
0.86A22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		4zzy POLY [ADP-RIBOSE]
POLYMERASE 2
(Homo
sapiens)		6 / 8HIS A 428
GLY A 429
TYR A 462
ALA A 464
LYS A 469
SER A 470
D7N  A1584 (-3.6A)
D7N  A1584 (-3.8A)
D7N  A1584 (-3.7A)
D7N  A1584 (-3.2A)
D7N  A1584 (-3.9A)
D7N  A1584 (-2.7A)
0.96A22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		4zzy POLY [ADP-RIBOSE]
POLYMERASE 2
(Homo
sapiens)		6 / 8HIS A 428
GLY A 429
TYR A 462
ALA A 464
SER A 470
TYR A 473
D7N  A1584 (-3.6A)
D7N  A1584 (-3.8A)
D7N  A1584 (-3.7A)
D7N  A1584 (-3.2A)
D7N  A1584 (-2.7A)
D7N  A1584 (-3.8A)
0.40A22.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		5dcz TANKYRASE-2
(Homo
sapiens)		8 / 8HIS A1031
GLY A1032
TYR A1060
ALA A1062
LYS A1067
SER A1068
TYR A1071
GLU A1138
59B  A1203 (-4.1A)
59B  A1203 (-4.1A)
59B  A1203 (-4.3A)
59B  A1203 (-3.5A)
PO4  A1202 (-2.7A)
59B  A1203 (-2.8A)
59B  A1203 (-3.3A)
59B  A1203 (-3.7A)
0.21A96.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		5dsy POLY [ADP-RIBOSE]
POLYMERASE 2
(Homo
sapiens)		7 / 8HIS A 415
GLY A 416
TYR A 449
ALA A 451
LYS A 456
SER A 457
GLU A 545
UHB  A1001 (-3.7A)
UHB  A1001 (-3.9A)
UHB  A1001 (-3.8A)
UHB  A1001 ( 4.1A)
UHB  A1001 ( 4.6A)
UHB  A1001 (-2.5A)
UHB  A1001 (-3.5A)
1.29A29.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		5dsy POLY [ADP-RIBOSE]
POLYMERASE 2
(Homo
sapiens)		7 / 8HIS A 415
GLY A 416
TYR A 449
ALA A 451
SER A 457
TYR A 460
GLU A 545
UHB  A1001 (-3.7A)
UHB  A1001 (-3.9A)
UHB  A1001 (-3.8A)
UHB  A1001 ( 4.1A)
UHB  A1001 (-2.5A)
UHB  A1001 (-3.4A)
UHB  A1001 (-3.5A)
0.78A29.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		5hcc COMPLEMENT C5
(Homo
sapiens)		4 / 8GLY A1072
TYR A1124
SER A1073
GLU A1120
None
0.79A12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		5lx6 POLY [ADP-RIBOSE]
POLYMERASE 10
(Homo
sapiens)		6 / 8HIS A 887
GLY A 888
TYR A 919
ALA A 921
SER A 927
TYR A 932
78P  A1101 (-4.0A)
78P  A1101 (-3.7A)
78P  A1101 (-3.7A)
78P  A1101 ( 4.2A)
78P  A1101 (-2.8A)
78P  A1101 (-3.8A)
0.39A25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		5xst POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens)		6 / 8HIS A 201
GLY A 202
ALA A 237
LYS A 242
SER A 243
GLU A 327
8E6  A 401 (-3.5A)
8E6  A 401 (-3.9A)
8E6  A 401 (-3.5A)
8E6  A 401 (-4.3A)
8E6  A 401 (-2.6A)
8E6  A 401 (-3.9A)
1.32A15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		5xst POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens)		6 / 8HIS A 201
GLY A 202
ALA A 237
SER A 243
TYR A 246
GLU A 327
8E6  A 401 (-3.5A)
8E6  A 401 (-3.9A)
8E6  A 401 (-3.5A)
8E6  A 401 (-2.6A)
8E6  A 401 (-3.4A)
8E6  A 401 (-3.9A)
0.77A15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		5xst POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens)		6 / 8HIS A 201
GLY A 202
TYR A 235
ALA A 237
LYS A 242
SER A 243
8E6  A 401 (-3.5A)
8E6  A 401 (-3.9A)
8E6  A 401 (-4.1A)
8E6  A 401 (-3.5A)
8E6  A 401 (-4.3A)
8E6  A 401 (-2.6A)
0.94A15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		5xst POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens)		6 / 8HIS A 201
GLY A 202
TYR A 235
ALA A 237
SER A 243
TYR A 246
8E6  A 401 (-3.5A)
8E6  A 401 (-3.9A)
8E6  A 401 (-4.1A)
8E6  A 401 (-3.5A)
8E6  A 401 (-2.6A)
8E6  A 401 (-3.4A)
0.35A15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		6bhv POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens)		5 / 8HIS A 862
GLY A 863
SER A 904
TYR A 907
GLU A 988
DQV  A1101 (-3.6A)
DQV  A1101 (-3.8A)
DQV  A1101 (-2.7A)
DQV  A1101 (-3.7A)
DQV  A1101 (-3.3A)
0.67A16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		6bhv POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens)		6 / 8HIS A 862
GLY A 863
TYR A 896
ALA A 898
LYS A 903
SER A 904
DQV  A1101 (-3.6A)
DQV  A1101 (-3.8A)
DQV  A1101 (-3.5A)
DQV  A1101 ( 4.1A)
DQV  A1101 ( 4.9A)
DQV  A1101 (-2.7A)
0.96A16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		6bhv POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens)		6 / 8HIS A 862
GLY A 863
TYR A 896
ALA A 898
SER A 904
TYR A 907
DQV  A1101 (-3.6A)
DQV  A1101 (-3.8A)
DQV  A1101 (-3.5A)
DQV  A1101 ( 4.1A)
DQV  A1101 (-2.7A)
DQV  A1101 (-3.7A)
0.35A16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		6eot DIPEPTIDYL PEPTIDASE
8
(Homo
sapiens)		4 / 8HIS A 752
GLY A 753
ALA A 775
SER A 761
None
0.86A15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RV6_A_RPBA1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		1htn TETRANECTIN
(Homo
sapiens)		5 / 11GLY A  90
TYR A  97
ALA A  95
SER A  91
GLU A  98
None
1.32A21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RV6_A_RPBA1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		2pqf POLY [ADP-RIBOSE]
POLYMERASE 12
(Homo
sapiens)		6 / 11HIS A 564
GLY A 565
TYR A 596
ALA A 598
SER A 604
TYR A 607
GAB  A 701 ( 3.7A)
GAB  A 701 (-3.6A)
GAB  A 701 (-4.5A)
GAB  A 701 (-3.3A)
GAB  A 701 (-2.8A)
GAB  A 701 (-3.3A)
0.38A23.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RV6_A_RPBA1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		3c49 POLY(ADP-RIBOSE)
POLYMERASE 3
(Homo
sapiens)		7 / 11HIS A 384
GLY A 385
TYR A 414
ALA A 416
LYS A 421
SER A 422
GLU A 514
KU8  A 601 (-4.0A)
KU8  A 601 (-3.5A)
KU8  A 601 (-4.1A)
KU8  A 601 ( 4.0A)
KU8  A 601 (-4.3A)
KU8  A 601 (-2.9A)
KU8  A 601 (-3.9A)
0.96A37.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RV6_A_RPBA1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		3c49 POLY(ADP-RIBOSE)
POLYMERASE 3
(Homo
sapiens)		7 / 11HIS A 384
GLY A 385
TYR A 414
ALA A 416
SER A 422
TYR A 425
GLU A 514
KU8  A 601 (-4.0A)
KU8  A 601 (-3.5A)
KU8  A 601 (-4.1A)
KU8  A 601 ( 4.0A)
KU8  A 601 (-2.9A)
KU8  A 601 (-3.5A)
KU8  A 601 (-3.9A)
0.55A37.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RV6_A_RPBA1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		3hkv POLY [ADP-RIBOSE]
POLYMERASE 10
(Homo
sapiens)		6 / 11HIS A 887
GLY A 888
TYR A 919
ALA A 921
SER A 927
TYR A 932
3AB  A1025 (-3.8A)
3AB  A1025 (-3.5A)
3AB  A1025 (-4.4A)
3AB  A1025 ( 3.9A)
3AB  A1025 (-2.8A)
3AB  A1025 (-3.7A)
0.48A19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RV6_A_RPBA1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		4f0e POLY [ADP-RIBOSE]
POLYMERASE 15
(Homo
sapiens)		6 / 11HIS A 537
GLY A 538
TYR A 569
ALA A 571
SER A 577
TYR A 582
0RU  A 701 (-3.7A)
0RU  A 701 (-3.3A)
0RU  A 701 (-4.3A)
None
0RU  A 701 (-3.5A)
0RU  A 701 (-3.7A)
0.43A20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RV6_A_RPBA1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		4f92 U5 SMALL NUCLEAR
RIBONUCLEOPROTEIN
200 KDA HELICASE
(Homo
sapiens)		5 / 11GLU B1361
GLY B1353
TYR B1378
ALA B1350
SER B1354
None
1.45A12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RV6_A_RPBA1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		4l2k TANKYRASE-2
(Homo
sapiens)		6 / 11HIS A1031
GLY A1032
TYR A1060
ALA A1062
LYS A1067
SER A1068
1V8  A1201 (-4.2A)
1V8  A1201 (-3.7A)
1V8  A1201 (-4.7A)
1V8  A1201 (-3.6A)
SO4  A1203 ( 2.8A)
1V8  A1201 (-2.7A)
1.06A19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RV6_A_RPBA1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		4l2k TANKYRASE-2
(Homo
sapiens)		6 / 11HIS A1031
GLY A1032
TYR A1060
ALA A1062
SER A1068
TYR A1071
1V8  A1201 (-4.2A)
1V8  A1201 (-3.7A)
1V8  A1201 (-4.7A)
1V8  A1201 (-3.6A)
1V8  A1201 (-2.7A)
1V8  A1201 (-3.3A)
0.47A19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RV6_A_RPBA1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		4oa7 TANKYRASE-1
(Homo
sapiens)		7 / 11HIS A1184
GLY A1185
TYR A1213
ALA A1215
LYS A1220
SER A1221
GLU A1291
2XS  A1402 (-4.2A)
None
2XS  A1402 (-4.2A)
None
None
None
None
0.65A22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RV6_A_RPBA1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		4oa7 TANKYRASE-1
(Homo
sapiens)		7 / 11HIS A1184
GLY A1185
TYR A1213
ALA A1215
SER A1221
TYR A1224
GLU A1291
2XS  A1402 (-4.2A)
None
2XS  A1402 (-4.2A)
None
None
2XS  A1402 ( 3.9A)
None
0.78A22.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RV6_A_RPBA1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		4oqa POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens)		10 / 11GLN C 759
HIS C 862
GLY C 863
TYR C 889
TYR C 896
ALA C 898
LYS C 903
SER C 904
TYR C 907
GLU C 988
None
2US  C1101 (-3.7A)
2US  C1101 (-3.3A)
2US  C1101 (-3.3A)
2US  C1101 (-4.2A)
2US  C1101 (-3.5A)
2US  C1101 ( 4.8A)
2US  C1101 (-3.4A)
2US  C1101 (-3.5A)
2US  C1101 (-3.2A)
0.57A79.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RV6_A_RPBA1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		4oqa POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens)		6 / 11GLU C 763
HIS C 862
GLY C 863
ALA C 898
SER C 904
TYR C 907
None
2US  C1101 (-3.7A)
2US  C1101 (-3.3A)
2US  C1101 (-3.5A)
2US  C1101 (-3.4A)
2US  C1101 (-3.5A)
0.86A79.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RV6_A_RPBA1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		4py4 POLY [ADP-RIBOSE]
POLYMERASE 14
(Homo
sapiens)		6 / 11HIS A1682
GLY A1683
TYR A1714
ALA A1716
SER A1722
TYR A1727
XL2  A1901 (-4.0A)
XL2  A1901 (-3.6A)
XL2  A1901 (-3.7A)
XL2  A1901 (-3.4A)
XL2  A1901 (-2.6A)
XL2  A1901 (-3.6A)
0.38A20.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RV6_A_RPBA1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		4zzy POLY [ADP-RIBOSE]
POLYMERASE 2
(Homo
sapiens)		9 / 11HIS A 428
GLY A 429
TYR A 455
TYR A 462
ALA A 464
LYS A 469
SER A 470
TYR A 473
GLU A 558
D7N  A1584 (-3.6A)
D7N  A1584 (-3.8A)
D7N  A1584 (-3.7A)
D7N  A1584 (-3.7A)
D7N  A1584 (-3.2A)
D7N  A1584 (-3.9A)
D7N  A1584 (-2.7A)
D7N  A1584 (-3.8A)
D7N  A1584 (-3.9A)
0.46A46.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RV6_A_RPBA1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		5dcz TANKYRASE-2
(Homo
sapiens)		6 / 11HIS A1031
GLY A1032
ALA A1062
SER A1068
TYR A1071
GLU A1138
59B  A1203 (-4.1A)
59B  A1203 (-4.1A)
59B  A1203 (-3.5A)
59B  A1203 (-2.8A)
59B  A1203 (-3.3A)
59B  A1203 (-3.7A)
0.91A22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RV6_A_RPBA1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		5dcz TANKYRASE-2
(Homo
sapiens)		6 / 11HIS A1031
GLY A1032
TYR A1060
ALA A1062
LYS A1067
SER A1068
59B  A1203 (-4.1A)
59B  A1203 (-4.1A)
59B  A1203 (-4.3A)
59B  A1203 (-3.5A)
PO4  A1202 (-2.7A)
59B  A1203 (-2.8A)
1.11A22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RV6_A_RPBA1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		5dcz TANKYRASE-2
(Homo
sapiens)		6 / 11HIS A1031
GLY A1032
TYR A1060
ALA A1062
SER A1068
TYR A1071
59B  A1203 (-4.1A)
59B  A1203 (-4.1A)
59B  A1203 (-4.3A)
59B  A1203 (-3.5A)
59B  A1203 (-2.8A)
59B  A1203 (-3.3A)
0.43A22.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RV6_A_RPBA1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		5dsy POLY [ADP-RIBOSE]
POLYMERASE 2
(Homo
sapiens)		9 / 11HIS A 415
GLY A 416
TYR A 442
TYR A 449
ALA A 451
LYS A 456
SER A 457
TYR A 460
GLU A 545
UHB  A1001 (-3.7A)
UHB  A1001 (-3.9A)
UHB  A1001 ( 4.7A)
UHB  A1001 (-3.8A)
UHB  A1001 ( 4.1A)
UHB  A1001 ( 4.6A)
UHB  A1001 (-2.5A)
UHB  A1001 (-3.4A)
UHB  A1001 (-3.5A)
0.57A40.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RV6_A_RPBA1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		5lx6 POLY [ADP-RIBOSE]
POLYMERASE 10
(Homo
sapiens)		6 / 11HIS A 887
GLY A 888
TYR A 919
ALA A 921
SER A 927
TYR A 932
78P  A1101 (-4.0A)
78P  A1101 (-3.7A)
78P  A1101 (-3.7A)
78P  A1101 ( 4.2A)
78P  A1101 (-2.8A)
78P  A1101 (-3.8A)
0.53A20.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RV6_A_RPBA1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		5xst POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens)		10 / 11GLN A  98
GLU A 102
HIS A 201
GLY A 202
TYR A 228
TYR A 235
ALA A 237
LYS A 242
TYR A 246
GLU A 327
8E6  A 401 ( 4.7A)
8E6  A 401 (-4.2A)
8E6  A 401 (-3.5A)
8E6  A 401 (-3.9A)
8E6  A 401 (-3.7A)
8E6  A 401 (-4.1A)
8E6  A 401 (-3.5A)
8E6  A 401 (-4.3A)
8E6  A 401 (-3.4A)
8E6  A 401 (-3.9A)
0.74A98.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RV6_A_RPBA1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		5xst POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens)		10 / 11GLN A  98
GLU A 102
HIS A 201
GLY A 202
TYR A 235
ALA A 237
LYS A 242
SER A 243
TYR A 246
GLU A 327
8E6  A 401 ( 4.7A)
8E6  A 401 (-4.2A)
8E6  A 401 (-3.5A)
8E6  A 401 (-3.9A)
8E6  A 401 (-4.1A)
8E6  A 401 (-3.5A)
8E6  A 401 (-4.3A)
8E6  A 401 (-2.6A)
8E6  A 401 (-3.4A)
8E6  A 401 (-3.9A)
0.62A98.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RV6_A_RPBA1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		6bhv POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens)		9 / 11HIS A 862
GLY A 863
TYR A 889
TYR A 896
ALA A 898
LYS A 903
SER A 904
TYR A 907
GLU A 988
DQV  A1101 (-3.6A)
DQV  A1101 (-3.8A)
DQV  A1101 (-4.2A)
DQV  A1101 (-3.5A)
DQV  A1101 ( 4.1A)
DQV  A1101 ( 4.9A)
DQV  A1101 (-2.7A)
DQV  A1101 (-3.7A)
DQV  A1101 (-3.3A)
0.38A32.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RV6_B_RPBB1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		1htn TETRANECTIN
(Homo
sapiens)		5 / 11GLY A  90
TYR A  97
ALA A  95
SER A  91
GLU A  98
None
1.32A21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RV6_B_RPBB1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		2pqf POLY [ADP-RIBOSE]
POLYMERASE 12
(Homo
sapiens)		6 / 11HIS A 564
GLY A 565
TYR A 596
ALA A 598
SER A 604
TYR A 607
GAB  A 701 ( 3.7A)
GAB  A 701 (-3.6A)
GAB  A 701 (-4.5A)
GAB  A 701 (-3.3A)
GAB  A 701 (-2.8A)
GAB  A 701 (-3.3A)
0.37A23.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RV6_B_RPBB1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		3c49 POLY(ADP-RIBOSE)
POLYMERASE 3
(Homo
sapiens)		7 / 11HIS A 384
GLY A 385
TYR A 414
ALA A 416
LYS A 421
SER A 422
GLU A 514
KU8  A 601 (-4.0A)
KU8  A 601 (-3.5A)
KU8  A 601 (-4.1A)
KU8  A 601 ( 4.0A)
KU8  A 601 (-4.3A)
KU8  A 601 (-2.9A)
KU8  A 601 (-3.9A)
0.96A37.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RV6_B_RPBB1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		3c49 POLY(ADP-RIBOSE)
POLYMERASE 3
(Homo
sapiens)		7 / 11HIS A 384
GLY A 385
TYR A 414
ALA A 416
SER A 422
TYR A 425
GLU A 514
KU8  A 601 (-4.0A)
KU8  A 601 (-3.5A)
KU8  A 601 (-4.1A)
KU8  A 601 ( 4.0A)
KU8  A 601 (-2.9A)
KU8  A 601 (-3.5A)
KU8  A 601 (-3.9A)
0.55A37.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RV6_B_RPBB1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		3hkv POLY [ADP-RIBOSE]
POLYMERASE 10
(Homo
sapiens)		6 / 11HIS A 887
GLY A 888
TYR A 919
ALA A 921
SER A 927
TYR A 932
3AB  A1025 (-3.8A)
3AB  A1025 (-3.5A)
3AB  A1025 (-4.4A)
3AB  A1025 ( 3.9A)
3AB  A1025 (-2.8A)
3AB  A1025 (-3.7A)
0.48A19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RV6_B_RPBB1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		4f0e POLY [ADP-RIBOSE]
POLYMERASE 15
(Homo
sapiens)		6 / 11HIS A 537
GLY A 538
TYR A 569
ALA A 571
SER A 577
TYR A 582
0RU  A 701 (-3.7A)
0RU  A 701 (-3.3A)
0RU  A 701 (-4.3A)
None
0RU  A 701 (-3.5A)
0RU  A 701 (-3.7A)
0.44A20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RV6_B_RPBB1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		4f92 U5 SMALL NUCLEAR
RIBONUCLEOPROTEIN
200 KDA HELICASE
(Homo
sapiens)		5 / 11GLU B1361
GLY B1353
TYR B1378
ALA B1350
SER B1354
None
1.44A12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RV6_B_RPBB1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		4l2k TANKYRASE-2
(Homo
sapiens)		6 / 11HIS A1031
GLY A1032
TYR A1060
ALA A1062
LYS A1067
SER A1068
1V8  A1201 (-4.2A)
1V8  A1201 (-3.7A)
1V8  A1201 (-4.7A)
1V8  A1201 (-3.6A)
SO4  A1203 ( 2.8A)
1V8  A1201 (-2.7A)
1.05A19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RV6_B_RPBB1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		4l2k TANKYRASE-2
(Homo
sapiens)		6 / 11HIS A1031
GLY A1032
TYR A1060
ALA A1062
SER A1068
TYR A1071
1V8  A1201 (-4.2A)
1V8  A1201 (-3.7A)
1V8  A1201 (-4.7A)
1V8  A1201 (-3.6A)
1V8  A1201 (-2.7A)
1V8  A1201 (-3.3A)
0.46A19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RV6_B_RPBB1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		4oa7 TANKYRASE-1
(Homo
sapiens)		7 / 11HIS A1184
GLY A1185
TYR A1213
ALA A1215
LYS A1220
SER A1221
GLU A1291
2XS  A1402 (-4.2A)
None
2XS  A1402 (-4.2A)
None
None
None
None
0.65A22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RV6_B_RPBB1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		4oa7 TANKYRASE-1
(Homo
sapiens)		7 / 11HIS A1184
GLY A1185
TYR A1213
ALA A1215
SER A1221
TYR A1224
GLU A1291
2XS  A1402 (-4.2A)
None
2XS  A1402 (-4.2A)
None
None
2XS  A1402 ( 3.9A)
None
0.77A22.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RV6_B_RPBB1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		4oqa POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens)		10 / 11GLN C 759
HIS C 862
GLY C 863
TYR C 889
TYR C 896
ALA C 898
LYS C 903
SER C 904
TYR C 907
GLU C 988
None
2US  C1101 (-3.7A)
2US  C1101 (-3.3A)
2US  C1101 (-3.3A)
2US  C1101 (-4.2A)
2US  C1101 (-3.5A)
2US  C1101 ( 4.8A)
2US  C1101 (-3.4A)
2US  C1101 (-3.5A)
2US  C1101 (-3.2A)
0.57A79.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RV6_B_RPBB1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		4oqa POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens)		6 / 11GLU C 763
HIS C 862
GLY C 863
ALA C 898
SER C 904
TYR C 907
None
2US  C1101 (-3.7A)
2US  C1101 (-3.3A)
2US  C1101 (-3.5A)
2US  C1101 (-3.4A)
2US  C1101 (-3.5A)
0.87A79.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RV6_B_RPBB1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		4py4 POLY [ADP-RIBOSE]
POLYMERASE 14
(Homo
sapiens)		6 / 11HIS A1682
GLY A1683
TYR A1714
ALA A1716
SER A1722
TYR A1727
XL2  A1901 (-4.0A)
XL2  A1901 (-3.6A)
XL2  A1901 (-3.7A)
XL2  A1901 (-3.4A)
XL2  A1901 (-2.6A)
XL2  A1901 (-3.6A)
0.38A20.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RV6_B_RPBB1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		4zzy POLY [ADP-RIBOSE]
POLYMERASE 2
(Homo
sapiens)		9 / 11HIS A 428
GLY A 429
TYR A 455
TYR A 462
ALA A 464
LYS A 469
SER A 470
TYR A 473
GLU A 558
D7N  A1584 (-3.6A)
D7N  A1584 (-3.8A)
D7N  A1584 (-3.7A)
D7N  A1584 (-3.7A)
D7N  A1584 (-3.2A)
D7N  A1584 (-3.9A)
D7N  A1584 (-2.7A)
D7N  A1584 (-3.8A)
D7N  A1584 (-3.9A)
0.47A46.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RV6_B_RPBB1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		5dcz TANKYRASE-2
(Homo
sapiens)		6 / 11HIS A1031
GLY A1032
ALA A1062
SER A1068
TYR A1071
GLU A1138
59B  A1203 (-4.1A)
59B  A1203 (-4.1A)
59B  A1203 (-3.5A)
59B  A1203 (-2.8A)
59B  A1203 (-3.3A)
59B  A1203 (-3.7A)
0.91A22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RV6_B_RPBB1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		5dcz TANKYRASE-2
(Homo
sapiens)		6 / 11HIS A1031
GLY A1032
TYR A1060
ALA A1062
LYS A1067
SER A1068
59B  A1203 (-4.1A)
59B  A1203 (-4.1A)
59B  A1203 (-4.3A)
59B  A1203 (-3.5A)
PO4  A1202 (-2.7A)
59B  A1203 (-2.8A)
1.11A22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RV6_B_RPBB1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		5dcz TANKYRASE-2
(Homo
sapiens)		6 / 11HIS A1031
GLY A1032
TYR A1060
ALA A1062
SER A1068
TYR A1071
59B  A1203 (-4.1A)
59B  A1203 (-4.1A)
59B  A1203 (-4.3A)
59B  A1203 (-3.5A)
59B  A1203 (-2.8A)
59B  A1203 (-3.3A)
0.42A22.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RV6_B_RPBB1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		5dsy POLY [ADP-RIBOSE]
POLYMERASE 2
(Homo
sapiens)		9 / 11HIS A 415
GLY A 416
TYR A 442
TYR A 449
ALA A 451
LYS A 456
SER A 457
TYR A 460
GLU A 545
UHB  A1001 (-3.7A)
UHB  A1001 (-3.9A)
UHB  A1001 ( 4.7A)
UHB  A1001 (-3.8A)
UHB  A1001 ( 4.1A)
UHB  A1001 ( 4.6A)
UHB  A1001 (-2.5A)
UHB  A1001 (-3.4A)
UHB  A1001 (-3.5A)
0.57A40.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RV6_B_RPBB1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		5lx6 POLY [ADP-RIBOSE]
POLYMERASE 10
(Homo
sapiens)		6 / 11HIS A 887
GLY A 888
TYR A 919
ALA A 921
SER A 927
TYR A 932
78P  A1101 (-4.0A)
78P  A1101 (-3.7A)
78P  A1101 (-3.7A)
78P  A1101 ( 4.2A)
78P  A1101 (-2.8A)
78P  A1101 (-3.8A)
0.53A20.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RV6_B_RPBB1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		5xst POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens)		11 / 11GLN A  98
GLU A 102
HIS A 201
GLY A 202
TYR A 228
TYR A 235
ALA A 237
LYS A 242
SER A 243
TYR A 246
GLU A 327
8E6  A 401 ( 4.7A)
8E6  A 401 (-4.2A)
8E6  A 401 (-3.5A)
8E6  A 401 (-3.9A)
8E6  A 401 (-3.7A)
8E6  A 401 (-4.1A)
8E6  A 401 (-3.5A)
8E6  A 401 (-4.3A)
8E6  A 401 (-2.6A)
8E6  A 401 (-3.4A)
8E6  A 401 (-3.9A)
0.72A98.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RV6_B_RPBB1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		6bhv POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens)		9 / 11HIS A 862
GLY A 863
TYR A 889
TYR A 896
ALA A 898
LYS A 903
SER A 904
TYR A 907
GLU A 988
DQV  A1101 (-3.6A)
DQV  A1101 (-3.8A)
DQV  A1101 (-4.2A)
DQV  A1101 (-3.5A)
DQV  A1101 ( 4.1A)
DQV  A1101 ( 4.9A)
DQV  A1101 (-2.7A)
DQV  A1101 (-3.7A)
DQV  A1101 (-3.3A)
0.37A32.22